thrombolytic therapy

Summary

Summary: Use of infusions of fibrinolytic agents to destroy or dissolve thrombi in blood vessels or bypass grafts.

Top Publications

  1. ncbi Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials
    Ellen C Keeley
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Lancet 361:13-20. 2003
  2. ncbi The impact of recanalization on ischemic stroke outcome: a meta-analysis
    Joung Ho Rha
    Department of Neurology, Inha University Hospital, Incheon, Korea
    Stroke 38:967-73. 2007
  3. pmc Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Maarten G Lansberg
    Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA
    Chest 141:e601S-36S. 2012
  4. ncbi Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Lancet 352:1245-51. 1998
  5. ncbi Functional recovery after ischemic stroke--a matter of age: data from the Austrian Stroke Unit Registry
    M Knoflach
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neurology 78:279-85. 2012
  6. ncbi The iScore predicts effectiveness of thrombolytic therapy for acute ischemic stroke
    Gustavo Saposnik
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 43:1315-22. 2012
  7. ncbi Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Gregory W Albers
    Stanford University Medical Center, Stanford Stroke Center, 701 Welch Road, Palo Alto, CA 94304 1705, USA
    Chest 133:630S-669S. 2008
  8. ncbi ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999
    Elliott M Antman
    Circulation 110:588-636. 2004
  9. ncbi Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
  10. ncbi Association of admission blood glucose and outcome in patients treated with intravenous thrombolysis: results from the Safe Implementation of Treatments in Stroke International Stroke Thrombolysis Register (SITS-ISTR)
    Niaz Ahmed
    Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
    Arch Neurol 67:1123-30. 2010

Detail Information

Publications281 found, 100 shown here

  1. ncbi Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials
    Ellen C Keeley
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Lancet 361:13-20. 2003
    Many trials have been done to compare primary percutaneous transluminal coronary angioplasty (PTCA) with thrombolytic therapy for acute ST-segment elevation myocardial infarction (AMI)...
  2. ncbi The impact of recanalization on ischemic stroke outcome: a meta-analysis
    Joung Ho Rha
    Department of Neurology, Inha University Hospital, Incheon, Korea
    Stroke 38:967-73. 2007
    ....
  3. pmc Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Maarten G Lansberg
    Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA
    Chest 141:e601S-36S. 2012
    ..This article provides recommendations on the use of antithrombotic therapy in patients with stroke or transient ischemic attack (TIA)...
  4. ncbi Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators
    W Hacke
    Department of Neurology, University of Heidelberg, Germany
    Lancet 352:1245-51. 1998
    ..We have assessed the safety and efficacy of intravenous thrombolysis with alteplase (0.9 mg/kg bodyweight) within 6 h of stroke onset...
  5. ncbi Functional recovery after ischemic stroke--a matter of age: data from the Austrian Stroke Unit Registry
    M Knoflach
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Neurology 78:279-85. 2012
    ..To analyze the association between patient age and good functional outcome after ischemic stroke with special focus on young patients who were numerically underrepresented in previous evaluations...
  6. ncbi The iScore predicts effectiveness of thrombolytic therapy for acute ischemic stroke
    Gustavo Saposnik
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 43:1315-22. 2012
    Tools to predict the clinical response after intravenous thrombolytic therapy (tPA) are scarce. The iScore is an existing validated tool to estimate outcomes after an acute ischemic stroke...
  7. ncbi Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Gregory W Albers
    Stanford University Medical Center, Stanford Stroke Center, 701 Welch Road, Palo Alto, CA 94304 1705, USA
    Chest 133:630S-669S. 2008
    This article about treatment and prevention of stroke is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)...
  8. ncbi ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999
    Elliott M Antman
    Circulation 110:588-636. 2004
  9. ncbi Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
    To assess the efficacy and safety of bone marrow cell (BMC) therapy after thrombolytic therapy of an acute ST-elevation myocardial infarction (STEMI).
  10. ncbi Association of admission blood glucose and outcome in patients treated with intravenous thrombolysis: results from the Safe Implementation of Treatments in Stroke International Stroke Thrombolysis Register (SITS-ISTR)
    Niaz Ahmed
    Karolinska Stroke Research Unit, Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden
    Arch Neurol 67:1123-30. 2010
    ..To determine the association between admission blood glucose and outcome in ischemic stroke patients treated with thrombolysis...
  11. ncbi Time trends in systemic thrombolysis in a large hospital-based stroke registry
    O C Singer
    Klinik fur Neurologie, Universitatsklinik, Goethe Universitat, Frankfurt, Deutschland
    Cerebrovasc Dis 33:316-21. 2012
    ..The purpose of this study was to determine changes in systemic thrombolysis rates within an observation period of 7 years following the approval of rtPA therapy in Germany in a large state-wide stroke data set...
  12. ncbi Promoting thrombolysis in acute ischemic stroke
    Maaike Dirks
    Erasmus MC University Hospital Rotterdam, Department of Neurology, and Institute for Health Policy and Management, Erasmus University Rotterdam, Room H 673, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Stroke 42:1325-30. 2011
    ....
  13. ncbi Rapid neurological recovery after intravenous tissue plasminogen activator in stroke: prognostic factors and outcome
    Bejoy Machumpurath
    Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia
    Cerebrovasc Dis 31:278-83. 2011
    ..This has previously not been systematically studied. We aimed to examine its incidence, predictive factors and correlation with clinical outcomes...
  14. ncbi Off-label thrombolysis is not associated with poor outcome in patients with stroke
    Atte Meretoja
    Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
    Stroke 41:1450-8. 2010
    ..We studied whether off-label thrombolysis was associated with poorer outcome or increased rates of symptomatic intracerebral hemorrhage compared with on-label use...
  15. ncbi Proportion of patients treated with thrombolysis in a centralized versus a decentralized acute stroke care setting
    Maarten M H Lahr
    Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Stroke 43:1336-40. 2012
    ..The present study aimed to assess the impact of organizational models on the proportion of patients undergoing tPA treatment...
  16. pmc Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Richard P Whitlock
    Population Health Research Institute, McMaster University, David Braley Cardiac, Vascular, and Stroke Research Institute, 237 Barton St East, Room C1 114, Hamilton, ON, L8L 2X2, Canada
    Chest 141:e576S-600S. 2012
    ..Antithrombotic therapy in valvular disease is important to mitigate thromboembolism, but the hemorrhagic risk imposed must be considered...
  17. ncbi Magnetic Resonance Imaging-DRAGON score: 3-month outcome prediction after intravenous thrombolysis for anterior circulation stroke
    Guillaume Turc
    Service de Neurologie, Hopital Sainte Anne, 1 rue Cabanis, 75674 Paris Cedex 14, France
    Stroke 44:1323-8. 2013
    ..We adapted the score for patients undergoing MRI as the first-line diagnostic tool...
  18. ncbi Infarct size, ejection fraction, and mortality in diabetic patients with acute myocardial infarction treated with thrombolytic therapy
    Jorge R Alegria
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am Heart J 154:743-50. 2007
    ..The purpose of this study was to examine if larger infarct size explains the higher mortality in diabetic patients with acute ST-segment-elevation MI...
  19. ncbi Effectiveness of primary percutaneous coronary intervention compared with that of thrombolytic therapy in elderly patients with acute myocardial infarction
    Rajendra H Mehta
    University of Michigan, Ann Arbor, Mich, USA
    Am Heart J 147:253-9. 2004
    ..on the relative effectiveness of primary percutaneous coronary intervention (PCI) as compared with thrombolytic therapy (TT) in elderly patients with ST-elevation myocardial infarction (STEMI), particularly in the current era ..
  20. ncbi How to make better use of thrombolytic therapy in acute ischemic stroke
    Geoffrey A Donnan
    Florey Neuroscience Institutes, University of Melbourne, Level 2, 161 Barry Street, Carlton South, VIC 3053, Australia
    Nat Rev Neurol 7:400-9. 2011
    ..Elimination of prehospital and in-hospital delays is an urgent priority...
  21. ncbi Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke
    W M Clark
    Oregon Stroke Center, Portland 97201, USA
    JAMA 282:2019-26. 1999
    ..This restricts the number of patients who can be treated, since most stroke patients present more than 3 hours after symptom onset...
  22. pmc Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Lancet 379:2364-72. 2012
    ..The IST-3 trial adds substantial new data. We therefore assessed all the evidence from randomised trials for rt-PA in acute ischaemic stroke in an updated systematic review and meta-analysis...
  23. ncbi Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy
    Johanna A Miettinen
    University of Oulu, Department of Internal Medicine P O Box 5000 Kajaanintie 50, FIN 90014 University of Oulu, Oulu, Finland
    Heart 96:362-7. 2010
    ....
  24. ncbi Safety and outcome after thrombolysis in stroke patients with mild symptoms
    M Kohrmann
    Department of Neurology, University of Erlangen, Schwabachanlage 6, Erlangen, Germany
    Cerebrovasc Dis 27:160-6. 2009
    b>Thrombolytic therapy is frequently withheld in patients with minor stroke symptoms...
  25. pmc Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis
    Maarten G Lansberg
    Stanford Stroke Center, Stanford University Medical Center, Palo Alto, CA 94304 9705, USA
    Stroke 40:2438-41. 2009
    ..The purpose of this study was to produce reliable and precise estimates of the treatment effect of tPA by pooling data from all relevant studies...
  26. ncbi Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to go
    Kim A Eagle
    University of Michigan Cardiovascular Center, Ann Arbor, MI 48109 0477, USA
    Eur Heart J 29:609-17. 2008
    ..Many patients who are eligible for acute reperfusion therapy receive it after substantial delays or not at all. We wanted to determine whether over the years more patients are receiving reperfusion therapy...
  27. pmc Impact of changing diagnostic criteria on incidence, management, and outcome of acute myocardial infarction: retrospective cohort study
    J P Pell
    Department of Medicine, Monklands Hospital, Airdrie, Lanarkshire ML6 0JS
    BMJ 326:134-5. 2003
  28. ncbi The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 37:2957-62. 2006
    ..Therefore, we aimed to develop a Stroke-Thrombolytic Predictive Instrument (TPI) to aid physicians considering thrombolysis for stroke...
  29. ncbi Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial
    K W Mahaffey
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 34:1711-20. 1999
    ..The Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial was designed to test the hypothesis that adenosine as an adjunct to thrombolysis would reduce myocardial infarct size...
  30. ncbi Prediction of 1-year survival after thrombolysis for acute myocardial infarction in the global utilization of streptokinase and TPA for occluded coronary arteries trial
    R M Califf
    Duke Clinical Research Institute, Durham, NC, USA
    Circulation 101:2231-8. 2000
    ..When a patient survives thrombolysis for acute myocardial infarction, little information from large studies exists from which to estimate prognosis during follow-up visits...
  31. ncbi Symptomatic intracerebral hemorrhage following thrombolytic therapy for acute ischemic stroke: a review of the risk factors
    Maarten G Lansberg
    Stanford University, Stanford Stroke Center, Palo Alto, CA 94304, USA
    Cerebrovasc Dis 24:1-10. 2007
    Symptomatic intracerebral hemorrhage (SICH) following thrombolytic therapy for acute ischemic stroke is associated with a high rate of morbidity and mortality...
  32. ncbi Routine early angioplasty after fibrinolysis for acute myocardial infarction
    Warren J Cantor
    Southlake Regional Health Centre, Newmarket, ON, Canada
    N Engl J Med 360:2705-18. 2009
    ..The role and optimal timing of routine PCI after fibrinolysis have not been established...
  33. ncbi Informed consent for thrombolytic therapy for patients with acute ischemic stroke treated in routine clinical practice
    Julie R Rosenbaum
    Department of Internal Medicine, Yale University School of Medicine, West Haven, Conn, USA
    Stroke 35:e353-5. 2004
    ..Our objectives were to determine how frequently informed consent is obtained when tPA is given to stroke patients in clinical practice and whether the person providing consent (patient or surrogate) was the appropriate decision-maker...
  34. ncbi Intravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse Stroke (STARS) study
    G W Albers
    Stanford Stroke Center, Stanford University Medical Center, Palo Alto, Calif 94304 1705, USA
    JAMA 283:1145-50. 2000
    ..Tissue-type plasminogen activator (tPA) is the only therapy for acute ischemic stroke approved by the Food and Drug Administration...
  35. ncbi Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats
    Toshihisa Sumii
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
    Stroke 33:831-6. 2002
    b>Thrombolytic therapy with tissue plasminogen activator (tPA) for acute ischemic stroke remains complicated by risks of hemorrhagic transformation...
  36. ncbi Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR
    Niaz Ahmed
    Department of Neurology, Karolinska University Hospital, and Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden
    Lancet Neurol 9:866-74. 2010
    ..5 h after stroke onset. We aimed to assess the implementation of the wider time window, its effect on the admission-to-treatment time, and safety and functional outcome in patients recorded in SITS-ISTR...
  37. ncbi Comparison of intravenous alteplase with a combined intravenous-endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study
    Mikael Mazighi
    Department of Neurology and Stroke Centre, Bichat University Hospital, Paris, France Diderot University, Paris, France
    Lancet Neurol 8:802-9. 2009
    ..The aim of this study was to ascertain the effect of a combined IV-endovascular approach (intra-arterial alteplase and, if required, additional thrombectomy) in patients with stroke due to arterial occlusion...
  38. ncbi Reperfusion therapy in elderly patients with acute myocardial infarction: a randomized comparison of primary angioplasty and thrombolytic therapy
    Menko Jan de Boer
    Department of Cardiology, Isala Klinieken lokatie de Weezenlanden, Groot Wezenland 20, 8011 JW Zwolle, The Netherlands
    J Am Coll Cardiol 39:1723-8. 2002
    This study sought to determine the short- and long-term outcome of primary coronary angioplasty and thrombolytic therapy for acute myocardial infarction (AMI) in patients older than 75 years of age.
  39. ncbi A systematic review of barriers to delivery of thrombolysis for acute stroke
    Joseph Kwan
    University Department of Geriatric Medicine, Level E MP807, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Age Ageing 33:116-21. 2004
    Barriers within the patient pathway can prevent early administration of thrombolytic therapy in patients admitted with acute stroke. This systematic review aimed to identify such barriers that have been reported in the medical literature.
  40. ncbi Novel end point analytic techniques and interpreting shifts across the entire range of outcome scales in acute stroke trials
    Jeffrey L Saver
    Stroke Center and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Stroke 38:3055-62. 2007
    ..8; coiling over clipping, 5.9; intra-arterial pro-urokinase in acute cerebral ischemia, 4.8; intravenous tissue plasminogen activator, 3.3...
  41. pmc MRI-based selection for intra-arterial stroke therapy: value of pretreatment diffusion-weighted imaging lesion volume in selecting patients with acute stroke who will benefit from early recanalization
    Albert J Yoo
    Department of Neuroradiology and Interventional Neuroradiology, Massachusetts General Hospital, 55 Fruit Street, Gray 241, Boston, MA 02114, USA
    Stroke 40:2046-54. 2009
    ..In patients with initial infarcts <70 cm(3), we sought to determine what effect recanalization and time to recanalization had on infarct growth and functional outcome...
  42. ncbi Modification of fibrin structure as a possible cause of thrombolytic resistance
    Boguslaw Lipinski
    Department of Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Thrombolysis 29:296-8. 2010
    ....
  43. pmc Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke
    Haihao Zhu
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 30:1137-46. 2010
    ..As a result, brain hemorrhage and infarction are reduced, and the time window for stroke reperfusion prolonged. Our present findings provide a promising new approach for enhancing tPA-based thrombolytic stroke therapy...
  44. ncbi Consent to thrombolysis in acute ischaemic stroke: from trial to practice
    Alfonso Ciccone
    Stroke Unit, Department of Neurosciences, Niguarda Hospital, Milan, Italy
    Lancet Neurol 2:375-8. 2003
    ..decision process allows the patients to express their point of view on the risk-to-benefit ratio of thrombolytic therapy, on the different outcomes of stroke, and on the effect of thrombolysis...
  45. ncbi Stroke thrombolysis: having more time translates into delayed therapy: data from the Austrian Stroke Unit Registry
    Julia Ferrari
    Department of Neurology, Hospital Barmherzige Brueder, Vienna, Austria
    Stroke 41:2001-4. 2010
    ..Previous small-scale studies suggested that the earlier patients arrive, the longer it takes to administer recombinant tissue plasminogen activator...
  46. pmc Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, Room 1242A, Calgary, AB T2N 2T9, Canada
    J Neurol Neurosurg Psychiatry 77:826-9. 2006
    ..The benefit of intravenous tissue plasminogen activator (tPA) given within 3 h of acute ischaemic stroke to patients over 80 years of age is uncertain...
  47. ncbi Management of unsuccessful thrombolysis in acute massive pulmonary embolism
    Nicolas Meneveau
    FESC, Department of Cardiology, University Hospital Jean Minjoz, Blvd Fleming, 25030 Besancon Cedex, France
    Chest 129:1043-50. 2006
    ..We aimed to compare rescue surgical embolectomy and repeat thrombolysis in patients who did not respond to thrombolysis...
  48. ncbi Intra-arterial thrombolysis for acute stroke in patients 80 and older: a comparison of results in patients younger than 80 years
    D Kim
    University of California at Los Angeles Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    AJNR Am J Neuroradiol 28:159-63. 2007
    ..The purpose of this study was to compare the baseline characteristics, complications, and outcomes between intra-arterially treated ischemic stroke patients aged > or = 80 years and their younger counterparts...
  49. ncbi Endovascular therapy of 623 patients with anterior circulation stroke
    Aekaterini Galimanis
    Department of Neurology, University of Bern, Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Stroke 43:1052-7. 2012
    ..The purpose of this study is to determine predictors of outcome in a large cohort of patients treated with intra-arterial thrombolysis, mechanical revascularization techniques, or both...
  50. ncbi Diffusion lesion reversal after thrombolysis: a MR correlate of early neurological improvement
    Marc Antoine Labeyrie
    Department of Radiology, Université Paris Descartes Sorbonne Paris Cité, Centre de Psychiatrie et Neursciences, Centre Hospitalier Sainte Anne, 1 rue Cabanis, 75674 Paris Cedex 14, France
    Stroke 43:2986-91. 2012
    ..We assessed the extent of reversible acute DWI lesions (RADs) and their relationships with clinical outcome in patients thrombolyzed≤4.5 hours from onset...
  51. ncbi Intravenous thrombolysis for stroke increases over time at primary stroke centers
    Shyam Prabhakaran
    Rush University Medical Center, Department of Neurological Sciences, Chicago, Illinois, USA
    Stroke 43:875-7. 2012
    ..We evaluated the impact that duration as a primary stroke center (PSC) had on tissue-type plasminogen activator (tPA) utilization for acute ischemic stroke...
  52. pmc Visual evaluation of perfusion computed tomography in acute stroke accurately estimates infarct volume and tissue viability
    K W Muir
    Division of Clinical Neurosciences, University of Glasgow, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, UK
    J Neurol Neurosurg Psychiatry 77:334-9. 2006
    ..To establish the validity of visual interpretation of immediately processed perfusion computed tomography (CT) maps in acute stroke for prediction of final infarction...
  53. pmc Risk factors of symptomatic intracerebral hemorrhage after tPA therapy for acute stroke
    Maarten G Lansberg
    Stanford University, Stanford Stroke Center, Palo Alto, California 94304, USA
    Stroke 38:2275-8. 2007
    ..MRI-based variables have generally not been included in predictive models, and little is known about the influence of reperfusion on SICH risk...
  54. ncbi Intraoperative thrombolysis in a patient with cardiopulmonary arrest undergoing caesarean delivery
    M Wenk
    Department of Anesthesiology and Intensive Care, St Franziskus Hospital Muenster, Muenster, Germany
    Anaesth Intensive Care 39:671-4. 2011
    ..The patient survived and was later discharged without any major neurological deficit...
  55. pmc Intravenous thrombolysis in acute ischaemic stroke: from trial exclusion criteria to clinical contraindications. An international Delphi study
    Maaike Dirks
    Erasmus MC, University Medical Centre, Department of Neurology, Room Ee 2240, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 78:685-9. 2007
    ..The trial context of these criteria hampers implementation in real life settings. We therefore aimed to obtain specialist opinion in a Delphi consensus on these contraindications...
  56. ncbi Increased use of thrombolytic therapy and shortening of in-hospital delays following acute ischemic stroke: experience on the establishment of a primary stroke center at a community hospital
    Sheng Feng Sung
    Department of Neurology, Chia Yi Christian Hospital, Chiayi City, Taiwan
    Acta Neurol Taiwan 19:246-52. 2010
    To improve and standardize stroke care, the establishment of primary stroke centers (PSCs) has been advised. Thrombolytic therapy has been proved to improve the outcome of acute ischemic stroke (AIS)...
  57. ncbi Massive pulmonary embolism: surgical embolectomy versus thrombolytic therapy--should surgical indications be revisited?
    Thierry Aymard
    Department of Cardiovascular Surgery, Berne University Hospital, University of Berne, Berne, Switzerland
    Eur J Cardiothorac Surg 43:90-4; discussion 94. 2013
    ..and quality of life (QoL) between patients primarily assigned to either pulmonary surgical embolectomy (SE) or thrombolytic therapy (TL). A subgroup of patients (TS) with failed responses to TL requiring SE was separately analysed.
  58. ncbi Mismatch-based delayed thrombolysis: a meta-analysis
    Nishant K Mishra
    University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary and Faculty of Medicine, University of Glasgow, Glasgow G116NT, UK
    Stroke 41:e25-33. 2010
    ..We undertook a meta-analysis of relevant trials to examine whether present evidence supports delayed thrombolysis among patients selected according to mismatch criteria...
  59. ncbi Recanalization after thrombolysis in stroke patients: predictors and prognostic implications
    A Zangerle
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Neurology 68:39-44. 2007
    ..To estimate rates, predictors, and prognostic importance of recanalization in an unselected series of patients with stroke treated with IV thrombolysis...
  60. ncbi Clot burden score on admission T2*-MRI predicts recanalization in acute stroke
    Laurence Legrand
    Department of Radiology, Centre Hospitalier Sainte Anne, Université Paris Descartes Sorbonne Paris Cité, Centre de psychiatrie et Neurosciences, INSERM S894, Paris, France
    Stroke 44:1878-84. 2013
    ..5 hours from onset...
  61. pmc Thrombolytic therapy is effective in paroxysmal nocturnal hemoglobinuria: a series of nine patients and a review of the literature
    David J Araten
    Division of Hematology, NYU School of Medicine, NYU Langone Cancer Center, New York, NY 10016, USA
    Haematologica 97:344-52. 2012
    ..Thrombosis is the major risk factor for death in patients with paroxysmal nocturnal hemoglobinuria. Previous case reports indicate that venous thrombosis in patients with paroxysmal nocturnal hemoglobinuria is amenable to thrombolysis...
  62. ncbi Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
    A Furlan
    Cerebrovascular Center, Department of Neurology, Cleveland Clinic Foundation, Ohio 44195, USA
    JAMA 282:2003-11. 1999
    ..Intravenous tissue-type plasminogen activator can be beneficial to some patients when given within 3 hours of stroke onset, but many patients present later after stroke onset and alternative treatments are needed...
  63. ncbi Pre-hospital 12-lead electrocardiography programs: a call for implementation by emergency medical services systems providing advanced life support--National Heart Attack Alert Program (NHAAP) Coordinating Committee; National Heart, Lung, and Blood Institu
    J Lee Garvey
    Carolinas Medical Center, Charlotte, North Carolina, USA
    J Am Coll Cardiol 47:485-91. 2006
    ....
  64. ncbi Relation of temporal creatine kinase-MB release and outcome after thrombolytic therapy for acute myocardial infarction. TAMI Study Group
    R H Christenson
    Department of Pathology, University of Maryland School of Medicine, Baltimore
    Am J Cardiol 85:543-7. 2000
    ..089). We conclude that CK-MB maximums relate to infarct zone function, left ventricular function, and in-hospital outcomes after thrombolysis for acute myocardial infarction...
  65. pmc Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence
    Denis Vivien
    Inserm UMR S 919, Serine Proteases and Pathophysiology of the Neurovascular Unit, GIP Cyceron, Universite de Caen Basse Normandie, Caen Cedex, France
    J Cereb Blood Flow Metab 31:2119-34. 2011
    ..The objective of the present review is to provide an overview of our present knowledge about the impact of tPA on the neurovascular unit during acute ischemic stroke...
  66. ncbi A qualitative assessment of practices associated with shorter door-to-needle time for thrombolytic therapy in acute ischemic stroke
    DaiWai M Olson
    Department of Neurology, Duke University Medical Center, Durham, NC, USA
    J Neurosci Nurs 43:329-36. 2011
    ..These included (a) communication and teamwork, (b) process, (c) organizational culture, (d) performance monitoring and feedback, and (e) overcoming barriers...
  67. ncbi Elevated serum S100B levels indicate a higher risk of hemorrhagic transformation after thrombolytic therapy in acute stroke
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Stroke 38:2491-5. 2007
    Intracerebral hemorrhage constitutes an often fatal sequela of thrombolytic therapy in patients with ischemic stroke...
  68. ncbi Thrombolytic therapy during cardiopulmonary resuscitation and the role of coagulation activation after cardiac arrest
    B W Böttiger
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Curr Opin Crit Care 7:176-83. 2001
    ..Nevertheless, because of the fear of severe bleeding complications, thrombolytic therapy during cardiopulmonary resuscitation (CPR) has been contraindicated...
  69. ncbi Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: a multicenter confirmatory study
    Mar Castellanos
    Department of Neurology, Hospital Universitari Doctor Josep Trueta, Girona, Spain
    Stroke 38:1855-9. 2007
    ..In this prospective study, we sought to validate the predictive capacity of the preestablished cutoff values of these biomarkers for PH in a larger series of patients...
  70. ncbi Therapy of basilar artery occlusion: a systematic analysis comparing intra-arterial and intravenous thrombolysis
    Perttu J Lindsberg
    Department of Neurology, Neurosciences Program, Biomedicum Helsinki, Helsinki, Finland
    Stroke 37:922-8. 2006
    ....
  71. ncbi US geographic distribution of rt-PA utilization by hospital for acute ischemic stroke
    Dawn Kleindorfer
    Department of Neurology, University of Cincinnati, Ohio 45267 0525, USA
    Stroke 40:3580-4. 2009
    ..We describe the US geographic distribution of hospitals using rt-PA for acute ischemic stroke...
  72. ncbi Major bleeding complications in cardiopulmonary resuscitation: the place of thrombolytic therapy in cardiac arrest due to massive pulmonary embolism
    Karin Janata
    Department of Emergency Medicine, Vienna General Hospital, Waehringer Guertel 18 20, 6D, A 1090, Vienna, Austria
    Resuscitation 57:49-55. 2003
    b>Thrombolytic therapy in patients with massive pulmonary embolism (MPE) and prolonged cardiopulmonary resuscitation (CPR) is subject to debate...
  73. ncbi Comparison of the predictive value of four different risk scores for outcomes of patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention
    Eli I Lev
    Cardiology Department, Rabin Medical Center, Petah Tikva, and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    Am J Cardiol 102:6-11. 2008
    ....
  74. pmc Noninvasive thrombolysis using pulsed ultrasound cavitation therapy - histotripsy
    Adam D Maxwell
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
    Ultrasound Med Biol 35:1982-94. 2009
    ..This phenomenon may provide a noninvasive method to filter and eliminate hazardous emboli during thrombolysis...
  75. pmc Association between stroke center hospitalization for acute ischemic stroke and mortality
    Ying Xian
    Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27705, USA
    JAMA 305:373-80. 2011
    ..Although stroke centers are widely accepted and supported, little is known about their effect on patient outcomes...
  76. ncbi Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, UK
    Lancet 350:607-14. 1997
    Recent trials of thrombolytic therapy in acute ischaemic stroke have given apparently conflicting results...
  77. pmc Microbubble-augmented ultrasound sonothrombolysis decreases intracranial hemorrhage in a rabbit model of acute ischemic stroke
    Rene Flores
    Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Invest Radiol 46:419-24. 2011
    ..We quantified the incidence of ICH associated with tPA thrombolysis and MB + US therapy and compared infarct volumes in a rabbit model of acute ischemic stroke...
  78. ncbi A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND)
    Henry Ma
    National Stroke Research Institute, Florey Neuroscience Institutes, Austin Health, University of Melbourne, Heidelberg Heights, Victoria, Australia
    Int J Stroke 7:74-80. 2012
    b>Thrombolytic therapy with tissue plasminogen activator is effective for acute ischaemic stroke within 4·5 h of onset. Patients who wake up with stroke are generally ineligible for stroke thrombolysis...
  79. ncbi Outcomes of intravenous thrombolysis after dissemination of the stroke code and designation of new referral hospitals in Catalonia: the Catalan Stroke Code and Thrombolysis (Cat-SCT) Monitored Study
    Sonia Abilleira
    Stroke Programme, Catalan Agency for Health Information, Assessment and Quality, Roc Boronat 81 95, 2a planta, 08005 Barcelona, Spain
    Stroke 42:2001-6. 2011
    ....
  80. ncbi The outcome wheel: a potential tool for shared decision-making in ischemic stroke thrombolysis
    Valorie L Cunningham
    Cowichan District Hospital, Duncan, British Columbia, Canada
    CJEM 10:545-51. 2008
    ..Until at least May 2011, an interactive version of this clinical tool kit will be available for download at www.sem-bc.com/cvatoolkit...
  81. ncbi Outcome of stroke with mild or rapidly improving symptoms
    Krassen Nedeltchev
    Department of Neurology, University Hospital of Bern, Bern, Switzerland
    Stroke 38:2531-5. 2007
    ..Therefore, thrombolysis with its potential risks does not seem to be justified in such patients. However, recent studies indicate that the outcome is not invariably benign...
  82. ncbi Methodology for antithrombotic and thrombolytic therapy guideline development: American College of Chest Physicians Evidence-based Clinical Practice Guidelines (8th Edition)
    Holger J Schunemann
    Department of Epidemiology, Italian National Cancer Institute Regina Elena, Via Elio Chianesi 53, Rome, Italy
    Chest 133:113S-122S. 2008
    ..methodologists to develop the eighth edition of ACCP evidence-based guidelines on antithrombotic and thrombolytic therapy. The process began with guideline authors specifying the population, intervention and alternative, and ..
  83. ncbi TESPI (Thrombolysis in Elderly Stroke Patients in Italy): a randomized controlled trial of alteplase (rt-PA) versus standard treatment in acute ischaemic stroke in patients aged more than 80 years where thrombolysis is initiated within three hours after s
    Svetlana Lorenzano
    Unità di Trattamento Neurovascolare, Department of Neurological Sciences, Policlinico Umberto I Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy
    Int J Stroke 7:250-7. 2012
    ..This article describes the design of the Thrombolysis in Elderly Stroke Patients in Italy (TESPI) trial planned to fill the lack of controlled data on i.v. thrombolysis in this age category of stroke patients...
  84. pmc A pilot randomized clinical safety study of sonothrombolysis augmentation with ultrasound-activated perflutren-lipid microspheres for acute ischemic stroke
    Andrei V Alexandrov
    Comprehensive Stroke Center Neurology, The University of Alabama at Birmingham, RWUH M226, 619 19th St South, Birmingham, AL 35249 3280, USA
    Stroke 39:1464-9. 2008
    ..Ultrasound transiently expands perflutren-lipid microspheres (muS), transmitting energy momentum to surrounding fluids. We report a pilot safety/feasibility study of ultrasound-activated muS with systemic tissue plasminogen activator (tPA)...
  85. ncbi Thrombolytic therapy for acute pulmonary embolism: a critical appraisal
    Jamie L Todd
    Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 135:1321-9. 2009
    ..for acute PE since the 1960s, to date there have been only 11 randomized controlled trials comparing thrombolytic therapy to conventional anticoagulation, and the numbers of patients included in these trials has been small...
  86. ncbi Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register
    K R Lees
    Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    QJM 101:863-9. 2008
    To describe the United Kingdom (UK) experience with thrombolytic therapy with intravenous alteplase (rt-PA) for stroke, as captured by the Implementation of Thrombolysis in Stroke (SITS) project.
  87. ncbi Response to intra-arterial and combined intravenous and intra-arterial thrombolytic therapy in patients with distal internal carotid artery occlusion
    Osama O Zaidat
    Department of Neurology, Case Western Reserve University University Hospitals of Cleveland, Ohio 44106, USA
    Stroke 33:1821-6. 2002
    ..The objective of this study was to determine the clinical features, angiographic findings, and response to treatment with thrombolytic therapy in patients with ischemic stroke caused by acute occlusion of the distal internal carotid artery.
  88. ncbi Role of fibrinogen levels and factor XIII V34L polymorphism in thrombolytic therapy in stroke patients
    Rocio Gonzalez-Conejero
    Centro Regional de Hemodonacion, Universidad de Murcia, Murcia, Spain
    Stroke 37:2288-93. 2006
    The identification of genetic and environmental factors that could improve the benefit/risk ratio of thrombolytic therapy in patients with ischemic stroke is crucial.
  89. ncbi Indications for thrombolysis in deep venous thrombosis
    P Gogalniceanu
    St George s Regional Vascular Institute, 4th Floor, St James Wing, St George s Hospital NHS Trust, Tooting, London SW17 0QT, United Kingdom
    Eur J Vasc Endovasc Surg 38:192-8. 2009
    ..Catheter directed thrombolysis (CDT) is an alternative method for treating DVTs but there is no consensus regarding indications for its use...
  90. pmc Stereotactic aspiration-thrombolysis of intracerebral hemorrhage and its impact on perihematoma brain edema
    J Ricardo Carhuapoma
    Division of Neurosciences Critical Care, Departments of Neurology, Neurosurgery and Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, 600 North Wolfe Street Meyer 8 140, Baltimore, MD 21287, USA
    Neurocrit Care 8:322-9. 2008
    ..To test this hypothesis, we report on the volumetric analysis of (1) the intraparenchymal hematoma and, (2) perihematomal edema in a cohort of ICH patients treated with intraclot rtPA...
  91. ncbi Epidemiology, risk and prognostic factors in mesenteric venous thrombosis
    S Acosta
    Vascular Centre, Malmo University Hospital, Malmo, Sweden
    Br J Surg 95:1245-51. 2008
    ..Epidemiological reports on risk and prognostic factors in patients with mesenteric venous thrombosis (MVT) are scarce...
  92. ncbi Years of disability-adjusted life gained as a result of thrombolytic therapy for acute ischemic stroke
    Keun Sik Hong
    Department of Neurology, Clinical Research Center, Ilsan Paik Hospital, Inje University, Goyang, Korea
    Stroke 41:471-7. 2010
    ..Widely used in epidemiological analyses, DALY has not been applied to acute stroke trials...
  93. ncbi Factors associated with in-hospital mortality after administration of thrombolysis in acute ischemic stroke patients: an analysis of the nationwide inpatient sample 1999 to 2002
    Brian T Bateman
    Columbia Presbyterian Medical College for Physicians and Surgeons, Columbia University, New York, NY, USA
    Stroke 37:440-6. 2006
    ..We therefore examined outcomes in acute stroke patients treated with thrombolysis using the largest discharge database available in the United States for the years 1999 to 2002...
  94. ncbi Uric acid levels are relevant in patients with stroke treated with thrombolysis
    Sergio Amaro
    Stroke Unit, Institute of Neurosciences, Hospital Clinic Barcelona, Barcelona, Spain
    Stroke 42:S28-32. 2011
    ..Uric acid (UA) is a neuroprotective antioxidant that improves the benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous UA also influences the response to thrombolysis in patients with stroke...
  95. ncbi Refining the perfusion-diffusion mismatch hypothesis
    K S Butcher
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia
    Stroke 36:1153-9. 2005
    ..There is no accepted standardized definition of PWI-DWI mismatch. We compared common mismatch definitions in the initial 40 EPITHET patients...
  96. ncbi Blood pressure and vessel recanalization in the first hours after ischemic stroke
    Heinrich P Mattle
    Department of Neurology, University of Berne, Freiburgstrasse, Inselspital, CH 3010 Berne, Switzerland
    Stroke 36:264-8. 2005
    ..Transient elevation of arterial blood pressure (BP) is frequent in acute ischemic stroke and may help to increase perfusion of tissue jeopardized by ischemia. If this is true, recanalization may eliminate the need for this BP elevation...
  97. ncbi Prediction of hemorrhagic transformation after thrombolytic therapy of clot embolism: an MRI investigation in rat brain
    C Neumann-Haefelin
    Department of Experimental Neurology, Max Planck Institute for Neurological Research, Cologne, Germany
    Stroke 33:1392-8. 2002
    ..Therefore, the potential of MRI for prediction of recombinant tissue plasminogen activator (rtPA)-induced bleeding is explored to identify patients in whom rtPA treatment may provoke such complications...
  98. ncbi New directions in thrombolytic therapy
    C F Toombs
    Product Development, Amgen Inc, Thousand Oaks, CA 91320, USA
    Curr Opin Pharmacol 1:164-8. 2001
    ..Finally, a new class of directly acting fibrinolytic agents is available...
  99. ncbi Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke
    Andrei V Alexandrov
    Stroke Treatment Team, University of Texas Houston Medical School, Houston 77030, USA
    N Engl J Med 351:2170-8. 2004
    ..Our objective was to determine whether ultrasonography can safely enhance the thrombolytic activity of t-PA...
  100. ncbi Thrombolytic therapy with recombinant tissue plasminogen activator for acute ischemic stroke: where do we go from here? A cumulative meta-analysis
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Stroke 34:1437-42. 2003
    ..Recombinant tissue plasminogen activator (rtPA; Actilyse) is not as widely used in clinical practice as it could be. Have new data since 1995 strengthened the evidence sufficiently to justify more widespread use of rtPA?..
  101. ncbi Utilization of intravenous tissue-type plasminogen activator for ischemic stroke at academic medical centers: the influence of ethnicity
    S C Johnston
    Neurovascular Service, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Stroke 32:1061-8. 2001
    ..We sought to measure the overall rate of usage of tissue-type plasminogen activator (tPA) for ischemic stroke at academic medical centers, and to determine whether ethnicity was associated with usage...

Research Grants64

  1. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..blood flow to ischemic tissues or organs has deleterious consequences in various clinical settings such as thrombolytic therapy, cardiopulmonary bypass, organ transplantation, and acute percutaneous coronary angioplasty...
  2. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..depriving PLD confers myocardial protection, with therapeutic potential in conjunction with currently used thrombolytic therapy. This grant will uncover targets that can be exploited pharmacologically to diminish the harmful presence ..
  3. Innate Immunity, Biomarkers and Myocardial Infarction
    Gregory L Stahl; Fiscal Year: 2010
    ..Preliminary data using the MBL assay in patients undergoing thrombolytic therapy for myocardial infarction demonstrate significantly higher MBL levels in MI patients that have died within ..
  4. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ....
  5. Mini-plasmin: Pre-Clinical Evaluation of a Novel Thrombolytic Strategy for Stroke
    Irina Y Sazonova; Fiscal Year: 2012
    ..project deals with a central problem in the field of acute stroke therapy, and we believe that improved thrombolytic therapy and outcomes for ischemic stroke should be directly translated into reduced mortality and morbidity...
  6. Therapeutic to Reduce Acute Inflammation Following Cardiac Ischemia
    ELISABETH M ALICOT-CARROLL; Fiscal Year: 2011
    ..2 million heart attacks annually in the US. In spite of advances made in thrombolytic therapy and angioplasty, up to 25% of men and 38% of women die within one year following a heart attack...
  7. The role of lectin-complexes in complement-mediated coagulopathy
    Laura R La Bonte; Fiscal Year: 2011
    ..is expected to significantly increase our knowledge regarding hemostasis, vascular occlusion, and thrombolytic therapy. Ultimately, if successful, results obtained in these studies will have a strong clinical and ..
  8. Thrombin Mediated Cytotoxicity during Cerebral Ischemia
    Patrick D Lyden; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although thrombolytic therapy for acute stroke continues to gain wider acceptance and usage, there remains a compelling need for neuroprotective therapy and new treatment to reduce thrombolytic ..
  9. Acute Collateral Enhancement in Focal Stroke
    Al C Ngai; Fiscal Year: 2010
    Acute management of ischemic stroke remains an important health problem. Thrombolytic therapy is effective but severely limited by the recommended 3-hour intravenous delivery window...
  10. Antithrombotic Therapy and Prevention of Thrombosis: ACCP Evidence-Based Clinical
    Sandra Zelman Lewis; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence- Based Guidelines, 9th Edition Development Conference Abstract-NHLBI The American College of Chest Physicians (..
  11. New York-Presbyterian NETT Consortium
    Stephan A Mayer; Fiscal Year: 2011
    ..for refractory status epilepticus, and clinical trials evaluating neuroprotective agents for acute stroke, thrombolytic therapy for intraventricular hemorrhage, and ultra-early hemostatic therapy with recombinant activated factor VII ..
  12. Continuous monitoring of anti-fibrinolytic therapy in cardiovascular surgery
    Francis G Spinale; Fiscal Year: 2012
    ..As a consequence, millions of patients that may be at risk for significant post-surgical bleeding will directly benefit from the development of this technology. ..
  13. Novel Neuroprotective/Restorative Therapy for Ischemic Stroke
    David E Smith; Fiscal Year: 2012
    ..Currently approved thrombolytic therapy suffers for a narrow therapeutic window and clearly other therapeutic strategies are needed, such as ..
  14. White Matter Protection in Acute Ischemic Stroke
    Chia Yi Kuan; Fiscal Year: 2012
    ..Thus, it remains uncertain whether thrombolytic therapy is sufficient, or additional cytoprotective agents are needed, to salvage WM in acute ischemic stroke...
  15. Ultrasound assisted thrombolysis for acute pulmonary embolism
    CURTIS GENSTLER; Fiscal Year: 2012
    ..of this project is to develop high power transducers and demonstrate feasibility of ultrasound-assisted thrombolytic therapy using high power catheter transducers to enable improved thrombus removal in massive pulmonary embolism at ..
  16. Mechanism of thrombolytic tPA induced intracerebral hemorrhage after stroke
    Daniel A Lawrence; Fiscal Year: 2013
    ..b>Thrombolytic therapy with tissue plasminogen activator (tPA) is the only approved treatment for ischemic stroke, but its use ..
  17. Novel Therapeutic Targets for Venous Thromboembolism
    THOMAS WILLIAM WAKEFIELD; Fiscal Year: 2012
    ..Although the standard treatment of venous thromboembolism is anticaogulation (and in some cases thrombolytic therapy), such treatment has significant bleeding potential, is associated with thrombus progression in up to 30% ..
  18. Establishment of fast pH MRI for imaging metabolic injury during acute stroke
    Phillip Zhe Sun; Fiscal Year: 2013
    ..There remains substantial interest in developing strategies to extend the thrombolytic therapy into subpopulations who may benefit from late intervention...
  19. Imaging Study of Combination Thrombolytic Therapy
    GEORGE JEROME SHAW; Fiscal Year: 2010
    ..drug delivery agents, and hypothermia that may improve stroke treatment and possibly reduce side effects of thrombolytic therapy. Improved effectiveness and/or greater safety in the use of thrombolytic therapy would provide a great ..
  20. Novel Neuroprotective/Anti-inflammatory Therapy for Ischemic Stroke
    David E Smith; Fiscal Year: 2010
    ..b>Thrombolytic therapy has been shown to improve perfusion to the ischemic penumbra, but it must be administered within three ..
  21. Imaging and Treating Inflammation in Stroke by Targeting Myeloperoxidase
    John W Chen; Fiscal Year: 2013
    ..provided by applicant): Treatment of stroke is limited to a few approved therapeutic options, such as thrombolytic therapy, that have to be administered within rigid short timeframes resulting in the exclusion of many patients...
  22. Ultrasound-Targeted Therapy for Acute Myocardial Infarction
    Sanjiv Kaul; Fiscal Year: 2013
    ..US, do not have access to such facilities and if they arrive at a regional hospital are likely to receive thrombolytic therapy that has a success rate of 60% in opening the infarct-related artery...
  23. Specialized Programs of Translational Research in Acute Stroke at the Partners
    Steven M Greenberg; Fiscal Year: 2013
    ..Core (Core A) leverages the considerable clinical resources at Partners to treat acute stroke patients with thrombolytic therapy as rapidly as possible, and enroll subjects in SPOTRIAS projects...
  24. Arterial Spin Labeled Perfusion MRI in Acute Ischemic Stroke
    DANNY JIONG JIONG WANG; Fiscal Year: 2013
    ..initial DEFUSE cohort study suggested that perfusion-diffusion mismatch may predict clinical responses to thrombolytic therapy. Randomized trials (e.g...
  25. Development of Stroke Point of Care Immunoassay for Cellular Fibronectin
    Albert K Man; Fiscal Year: 2010
    ..For ischemic stroke, which comprises approximately four-fifths of all strokes, thrombolytic therapy by tissue plasminogen activator (tPA) has been proven to be effective in the critical first 3 hours from ..
  26. Delivery of Anti-thrombotic Drugs by Blood Cells
    Vladimir R Muzykantov; Fiscal Year: 2012
    ..Implementation of this translational grant will provide a solid basis for clinical development of this potentially revolutionizing novel approach for thromboprophylaxis. ..
  27. Thrombolysis in Pediatric Stroke Study (TIPS)
    Catherine M Amlie-Lefond; Fiscal Year: 2013
    ..Intracranial hemorrhage following stroke can occur even in the absence of thrombolytic therapy, but the risk is increased by the use of thrombolytics...
  28. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..b>Thrombolytic therapy with tissue plasminogen activator (tPA) acts to increase blood flow to the ischemic tissue and is the only ..
  29. PAI-1 Targeted Intrapleural Fibronolytic Therapy
    Andrey Komissarov; Fiscal Year: 2012
    ..Ultimately, new interventions identified in this project could improve outcomes for thousands of afflicted US patients annually. ..
  30. Ultrasound-Assisted Thrombolysis for Stroke Therapy
    Christy K Holland; Fiscal Year: 2012
    ..significantly to our long-term goal to develop a sonothrombolysis system that delivers and enhances thrombolytic therapy in the cerebral vasculature and rapidly restores perfusion after ischemic stroke...
  31. Mannose binding lectin and outcomes following CABG
    GREGORY L contact STAHL; Fiscal Year: 2010
    ..infarction, it is now widely accepted that ischemia/reperfusion (I/R) injury occurs following successful thrombolytic therapy, percutaneous transluminal coronary angioplasty and coronary artery bypass grafting (CABG) with ..
  32. Sonolysis in Acute Coronary Syndromes
    Feng Xie; Fiscal Year: 2012
    ..It would serve as a more rapid, less costly, and safer approach to acute coronary syndromes than fibrinolytic therapy or emergent percutaneous coronary interventions. ..
  33. Imaging Collaterals in Acute Stroke (iCAS)
    GREGORY GEORGE ZAHARCHUK; Fiscal Year: 2013
    ..5-12 hr time window with large vessel occlusive stroke who are under consideration for endovascular thrombolytic therapy. We will add two ASL sequences to our rapid stroke protocol: pseudocontinuous ASL (pcASL, 2...
  34. CORONARY STENOSIS, VASOMOTION AND THROMBUS FORMATION
    WILLIAM SANTAMORE; Fiscal Year: 1990
    ..At the same time, post myocardial infarction thrombolytic therapy has proven to be very successful: a result which supports the view of an occlusive thrombus within the ..
  35. Ultra-sensitive magnetic assays for rapid detection of stroke biomarkers
    MARK S DIIORIO; Fiscal Year: 2012
    ..FDA approved thrombolytic therapy can be effective for acute ischemic stroke, the most common stroke, as long as it is administered within ..
  36. PROTEINASE IN FIBRINOLYSIS AND THROMBOLYTIC THERAPY
    STEVEN GONIAS; Fiscal Year: 1993
    ..concerns the proteinases, proteinase inhibitors, and cofactors that interact in normal fibrinolysis and thrombolytic therapy. The first aim is to understand the reaction of the thrombolytic complex, streptokinase-plasmin(ogen)(SkPl),..
  37. Development of annexin A2 plus tPA as a novel stroke thrombolytic therapy
    Xiaoying Wang; Fiscal Year: 2012
    ..a translational plan to develop recombinant Annexin A2 protein (rA2) plus low-dose tPA as a combination thrombolytic therapy for acute ischemic stroke...
  38. PLATELETS, PLATELET AGGREGATES & PLASMINOGEN ACTIVATION
    Joseph Loscalzo; Fiscal Year: 1991
    ..disorders, including myocardial infarction and stroke, and is a crucial event in reocclusion following thrombolytic therapy and transluminal balloon angioplasty...
  39. HEMOSTATIC EFFECTS OF FIBRINOLYTIC THERAPY
    BARBARA ALEVRIADOU; Fiscal Year: 2000
    ....
  40. MECHANISMS OF MYOCARDIAL REPERFUSION INJURY
    MERVYN FORMAN; Fiscal Year: 1991
    ..These studies will provide important information regarding the mechanisms of reperfusion injury in the canine model and the usefullness of various agents to limit this entity...
  41. STRUCTURE/FUNCTION STUDIES ON PLASMINOGEN AND PLASMIN
    Francis Castellino; Fiscal Year: 1999
    ..Important new thrombolytic agents, and/or strategies for application of thrombolytic therapy to human vascular disease, is expected to directly or indirectly result from the basic knowledge provided ..
  42. Translation of pH-weighted MRI to Image Human Acute Stroke
    ALMA SORENSEN; Fiscal Year: 2009
    ..On the other hand, could salvageable ischemic tissue be detected, the thrombolytic therapy can be individualized to benefit patients admitted beyond the traditional treatment window...
  43. MITOCHONDRIA INCREASE OXIDATIVE INJURY IN AGING HEART
    EDWARD LESNEFSKY JR; Fiscal Year: 1999
    ..older than age 75 with acute infarction in the Global Utilization of t-PA and Streptokinase Trial of thrombolytic therapy sustained larger infarcts compared to younger patients, and had greatly reduced recovery of contractile ..
  44. FIBRINOGEN--ROLE OF THE GAMMA VARIANT
    David Farrell; Fiscal Year: 2001
    ..The results from the experiments in this proposal should provide new knowledge about the process of blood coagulation that may lead to way of modulating fibrin clot stability and clot lysis in vivo. ..
  45. Transcranial Laser Therapy of Ischemic Stroke
    Piyush M Patel; Fiscal Year: 2013
    ..e. intracerebral hemorrhage [ICH]). Even thrombolytic therapy with tissue plasminogen activator (tPA) produces complete resolution of symptoms less than 40% of the time, ..
  46. INTEGRATIVE APPROACH TO CORONARY THROMBOSIS
    Robert Montgomery; Fiscal Year: 2001
    ..of stable and unstable angina, myocardial infarction and reocclusion of a coronary artery following thrombolytic therapy, form a spectrum of thrombotic related diseases in the coronary circulation...
  47. FUNCTIONAL CHARACTERISTICS OF THE LEFT HEART
    HAROLD DODGE; Fiscal Year: 1990
    ..These methods are also being applied to determine: (1) the effect of thrombolytic therapy in improving regional and global left and right ventricular performance in myocardial infarction, (2) the ..
  48. BASIC AND CLINICAL STUDIES OF COAGULATION PROTEINS
    Charles Francis; Fiscal Year: 2003
    ..catheter-directed versus systemic fibrinolysis of deep vein thrombosis, lys-plasminogen as an adjunct for thrombolytic therapy of peripheral arterial occlusion and anti-coagulant strategies for prophylaxis of thrombosis with central ..
  49. ENHANCING THROMBOLYSIS BY INHIBITION OF A2-ANTIPLASMIN
    Guy Reed; Fiscal Year: 1993
    I. Research Plan Thrombolytic therapy remains suboptimal because of difficulties with bleeding, incomplete lysis and rethrombosis...
  50. TIPI SYSTEMS TO REDUCE ERRORS IN EMERGENCY CARDIAC CARE
    HARRY SELKER; Fiscal Year: 2002
    ..In ED treatment, although for ED patients with AMI, the lifesaving impact of thrombolytic therapy is directly related to the earliness of its use, many are not treated promptly, and about 90,000 per year ..
  51. ROLE OF FIBRINOGEN IN FIBRINOLYSIS
    David Farrell; Fiscal Year: 2004
    ..The results from the experiments in this proposal should provide new knowledge about the process of fibrinolysis that may lead to ways of modulating fibrin clot stability and clot lysis in vivo. ..
  52. THROMBUS IMAGING BY RADIOLABELED MONOCLONAL ANTIBODIES
    Jamshid Maddahi; Fiscal Year: 1991
    ..2) Under control conditions, without thrombolytic therapy, thrombus activity gradually declines because of intrinsic thrombolysis...
  53. EMS Based TIPI-IS Cardiac Care QI/Error Reduction System
    HARRY SELKER; Fiscal Year: 2006
    ..e., thrombolytic therapy (TT) and primary percutaneous transluminal coronary angioplasty (PTCA), can be life-saving, if given ..
  54. Recombinant Des-Kringle Derivatives of Plasmin for Treatment of Peripheral Arteri
    XLNLI LIN; Fiscal Year: 2006
    ..Plasmin is the enzyme which actually dissolves the clot. Consequently, thrombolytic therapy of PAO with PA is not officially sanctioned by the FDA; but it still constitutes approximately 25% of all ..
  55. Enhancement of Thrombolysis through Inhibition of PAI-1 and Antiplasmin
    CHARLENE BLAKE; Fiscal Year: 2007
    ..Unfortunately, thrombolytic therapy is often incomplete and not uncommonly produces intracranial hemorrhage...
  56. THROMBOLYSIS IN MI (TIMI) II FOLLOW-UP
    Genell Knatterud; Fiscal Year: 1991
    The Thrombolysis in Myocardial Infarction (TIMI) Phase II study is designed to determine whether intravenous thrombolytic therapy given in the early hours of acute myocardial infarction should be followed by percutaneous transluminal ..
  57. Phase 2B Study of TNK in Acute Stroke
    E Haley; Fiscal Year: 2007
    ..To date, intravenous thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is the only treatment proven to be effective for ..
  58. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2004
    ..in cardiac morbidity and mortality following a myocardial infarction regardless of the administration of thrombolytic therapy, an early invasive approach, and the use of aspirin, ACE-inhibitors and beta-blockers...
  59. Stroke:Role of aPL, hemostatic markers, and telestroke
    Steven Levine; Fiscal Year: 2006
    ..directions for further study of aPL-P and hemostatic markers in acute ischemic stroke patients who receive thrombolytic therapy, and in stroke patients receiving either anticoagulant or antiplatelet therapy, as well as allow him time ..
  60. PLATELET-ENDOTHELIAL DYSFUNCTION BY FIBRINOGEN PEPTIDE
    Charles Chen; Fiscal Year: 1992
    ..FDPs/fdps are generated in conditions such as disseminated intravascular coagulation (DIC) and during thrombolytic therapy. The role of any specific low molecular weight FDPs/fdps (<5000 daltons) in causing the diffuse vascular ..
  61. Novel Anti-Thrombotic Approach for Treatment of Myocardial Infarction
    Tamie Chilcote; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. CORONARY THROMBOLYSIS AND PLATELET ACTIVATION
    Desmond Fitzgerald; Fiscal Year: 1992
    The clinical response to thrombolytic therapy in patients with acute myocardial infarction is limited by the failure to reperfuse the occluded vessel, severe residual stenosis and early reocclusion...
  63. ULTRASOUND ENHANCED THROMBOLYSIS FOR ISCHEMIC STROKE
    Andrei Alexandrov; Fiscal Year: 2004
    ..operator- independent ultrasound device and to demonstrate its effectiveness and safety in enhancing thrombolytic therapy for ischemic stroke...
  64. Electrophysiologic effects of late PCI (OAT-EP)
    Stephen Shorofsky; Fiscal Year: 2005
    ..However, it is now evident that the survival benefit associated with thrombolytic therapy is not consistently associated with a major improvement in left ventricular ejection fraction (LVEF)...