self administration

Summary

Summary: Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.

Top Publications

  1. ncbi Evidence for addiction-like behavior in the rat
    Véronique Deroche-Gamonet
    INSERM U588, Laboratoire de Physiopathologie des Comportements, Bordeaux Institute for Neurosciences, University Victor Segalen Bordeaux 2, Domaine de Carreire, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Science 305:1014-7. 2004
  2. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
  3. ncbi Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
  4. pmc N-Acetylcysteine reverses cocaine-induced metaplasticity
    Khaled Moussawi
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue BSB410, Charleston, South Carolina, USA
    Nat Neurosci 12:182-9. 2009
  5. ncbi Drug seeking becomes compulsive after prolonged cocaine self-administration
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 305:1017-9. 2004
  6. ncbi Transition to addiction is associated with a persistent impairment in synaptic plasticity
    Fernando Kasanetz
    INSERM U862, Neurocentre Magendie, 147 Rue Léo Saignat, 33077, Bordeaux Cedex, France
    Science 328:1709-12. 2010
  7. ncbi Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats
    Leontien Diergaarde
    Center for Neurogenomics and Cognitive Research, Department of Anatomy and Neurosciences, VU Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 63:301-8. 2008
  8. pmc Cocaine self-administration produces a persistent increase in dopamine D2 High receptors
    Lisa A Briand
    Neuroscience Program, The University of Michigan, United States
    Eur Neuropsychopharmacol 18:551-6. 2008
  9. ncbi Managing self-injection difficulties in patients with relapsing-remitting multiple sclerosis
    Darcy Cox
    University of California, San Francisco, USA
    J Neurosci Nurs 38:167-71. 2006
  10. ncbi PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 9:1050-6. 2006

Research Grants

Detail Information

Publications368 found, 100 shown here

  1. ncbi Evidence for addiction-like behavior in the rat
    Véronique Deroche-Gamonet
    INSERM U588, Laboratoire de Physiopathologie des Comportements, Bordeaux Institute for Neurosciences, University Victor Segalen Bordeaux 2, Domaine de Carreire, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Science 305:1014-7. 2004
    ..These findings provide a new basis for developing a true understanding and treatment of addiction...
  2. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
    ..These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences...
  3. ncbi Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
    ....
  4. pmc N-Acetylcysteine reverses cocaine-induced metaplasticity
    Khaled Moussawi
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue BSB410, Charleston, South Carolina, USA
    Nat Neurosci 12:182-9. 2009
    ..Our findings show that cocaine self-administration induces metaplasticity that inhibits further induction of synaptic plasticity, and this impairment can be reversed by NAC, a drug that also prevents relapse...
  5. ncbi Drug seeking becomes compulsive after prolonged cocaine self-administration
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 305:1017-9. 2004
    ....
  6. ncbi Transition to addiction is associated with a persistent impairment in synaptic plasticity
    Fernando Kasanetz
    INSERM U862, Neurocentre Magendie, 147 Rue Léo Saignat, 33077, Bordeaux Cedex, France
    Science 328:1709-12. 2010
    ..By making drug seeking consistently resistant to modulation by environmental contingencies and consequently more and more inflexible, a persistently impaired LTD could mediate the transition to addiction...
  7. ncbi Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats
    Leontien Diergaarde
    Center for Neurogenomics and Cognitive Research, Department of Anatomy and Neurosciences, VU Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 63:301-8. 2008
    ..Although heavy smoking has been associated with impulsivity in humans, it is not clear whether poor impulse control represents a risk factor in the etiology of nicotine dependence...
  8. pmc Cocaine self-administration produces a persistent increase in dopamine D2 High receptors
    Lisa A Briand
    Neuroscience Program, The University of Michigan, United States
    Eur Neuropsychopharmacol 18:551-6. 2008
    ..This may also help explain why stimuli that increase dopamine neurotransmission, including drugs themselves, are so effective in producing relapse in individuals with a history of exposure to cocaine...
  9. ncbi Managing self-injection difficulties in patients with relapsing-remitting multiple sclerosis
    Darcy Cox
    University of California, San Francisco, USA
    J Neurosci Nurs 38:167-71. 2006
    ..Nurses who are familiar with these tools have the opportunity to have a significant positive impact on patient comfort, confidence, and, ultimately, successful long-term adherence to disease-modifying medications...
  10. ncbi PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 9:1050-6. 2006
    ..Individual differences in the rate of recovery of D2 receptor function during abstinence were noted...
  11. pmc Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats
    Agustin Zapata
    Integrative Neuroscience Section, National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 30:15457-63. 2010
    ....
  12. ncbi High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge CB2 3EB, United Kingdom
    Biol Psychiatry 65:851-6. 2009
    ..Relapse is a hallmark feature of cocaine addiction and a main challenge for treatment strategies. Human studies indicate a link between impulsivity and increased susceptibility to relapse...
  13. pmc Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex
    Osnat Ben-Shahar
    Department of Psychology and the Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California 93106 9660, USA
    Synapse 63:598-609. 2009
    ..These data support the notion that altered NMDA function within the mPFC may contribute, in part, to the transition to excessive uncontrolled consumption of cocaine...
  14. pmc The ghrelin signalling system is involved in the consumption of sweets
    Sara Landgren
    Department of Pharmacology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 6:e18170. 2011
    ....
  15. ncbi Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats
    F C Colpaert
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Cedex, Castres, France
    Pain 91:33-45. 2001
    ..Paralleling patient-controlled analgesic drug intake, FSA offers a specific measure allowing the dynamic effects of neurobiological agents to be studied in this unique animal model of persistent nociceptive pain...
  16. ncbi Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats
    A D Le
    Department of Neuroscience, Center for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada, M5S 2S1
    Psychopharmacology (Berl) 179:366-73. 2005
    ..We also tested the effect of lofexidine and yohimbine on alcohol self-administration. Lofexidine is used clinically for treating opiate withdrawal symptoms and yohimbine induces stress-like responses in humans and non-humans...
  17. ncbi Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2
    Liana Fattore
    Institute of Neuroscience, National Research Council CNR, Section of Cagliari, Italy
    Eur J Neurosci 25:2191-200. 2007
    ....
  18. pmc Monitoring one-year compliance to antihypertension medication in the Seychelles
    Pascal Bovet
    Institut Universitaire de Medecine Sociale et Preventive, Lausanne, Switzerland
    Bull World Health Organ 80:33-9. 2002
    ..To examine the compliance to medication among newly diagnosed hypertensive patients screened from the general population of the Seychelles, a rapidly developing country...
  19. ncbi Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 22:6247-53. 2002
    ..These data indicate a possible involvement of the dopaminergic innervation of the dorsal striatum in well established, or habitual, cocaine-seeking behavior...
  20. pmc Exposure to cocaine regulates inhibitory synaptic transmission in the nucleus accumbens
    Mami Otaka
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 33:6753-8. 2013
    ....
  21. pmc Different adaptations in AMPA receptor transmission in the nucleus accumbens after short vs long access cocaine self-administration regimens
    Anthony Purgianto
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL, USA
    Neuropsychopharmacology 38:1789-97. 2013
    ..Together with data on cocaine infusions in each group, our results show that CP-AMPAR accumulation and enhanced glutamate transmission is associated with longer sessions (6 h), rather than the number of sessions or cocaine infusions...
  22. ncbi Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels
    Serge H Ahmed
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    J Neurochem 86:102-13. 2003
    ..These findings show that changes in cocaine efficacy or pharmacokinetics do not play a critical role in cocaine intake escalation...
  23. pmc Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats
    Maria Scherma
    Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 327:482-90. 2008
    ..These findings suggest that FAAH inhibition can counteract the addictive properties of nicotine and that FAAH may serve as a new target for development of medications for treatment of tobacco dependence...
  24. pmc Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model
    B A Nic Dhonnchadha
    Center for Addiction Research, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77550 1031, USA
    Behav Neurosci 123:382-96. 2009
    ....
  25. pmc Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada
    Neuropsychopharmacology 35:1751-60. 2010
    ..The findings point to alpha(1) adrenoceptor blockade as a potential new approach to the treatment of tobacco dependence in humans...
  26. ncbi Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior
    Alexander Kuzmin
    Department of Clinical Neuroscience, Division of Drug Dependence, Karolinska University Hospital, Bldg M1 01, 17176, Stockholm, Sweden
    Psychopharmacology (Berl) 203:99-108. 2009
    ....
  27. ncbi Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats
    Anton Y Bespalov
    Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
    Neuropharmacology 49:167-78. 2005
    ....
  28. ncbi Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents
    Liana Fattore
    Institute of Neuroscience, Section of Cagliari, National Research Council CNR, c o Department of Neuroscience, University of Cagliari, Cittadella Universitaria of Monserrato, Italy
    Eur Neuropsychopharmacol 19:487-98. 2009
    ..3 mg/kg) CPP in mice. Altogether, our results showed that baclofen is able to antagonise reinstatement of nicotine-seeking and CPP triggered by nicotine primings, suggesting its potential clinical utility as an anti-relapse agent...
  29. pmc Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5
    Carmela M Reichel
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 36:782-92. 2011
    ..These results from a clinically-relevant animal model of addiction suggest that mGluR5 receptor modulation may be a potential treatment of cognitive dysfunction in meth addiction...
  30. pmc Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence
    Yue Hao
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    Biol Psychiatry 68:240-8. 2010
    ..We examined here whether neuroadaptive dysregulation of metabotropic glutamate receptor function is a factor in escalating cocaine self-administration...
  31. ncbi Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 27:9077-85. 2007
    ..Together, these findings indicate an important role for mGlu2/3 receptors in the posterior VTA and the NAc shell in the mediation of the rewarding effects of nicotine and potentially in cue-induced nicotine-seeking behavior...
  32. ncbi Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats
    Neil E Paterson
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 30:119-28. 2005
    ..125 and 0.25 mg/kg) dose-dependently decreased cue-induced reinstatement of nicotine-seeking behavior...
  33. ncbi Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Neurosci 24:3554-62. 2004
    ....
  34. ncbi Trait-like impulsivity does not predict escalation of heroin self-administration in the rat
    Ruth McNamara
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 212:453-64. 2010
    ....
  35. pmc Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression
    Karolina P Skibicka
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden
    Addict Biol 17:95-107. 2012
    ..These findings suggest that ghrelin antagonists have therapeutic potential for the treatment of obesity and to suppress the overconsumption of sweet food...
  36. ncbi Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
    David A Baker
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Nat Neurosci 6:743-9. 2003
    ..Thus, withdrawal from repeated cocaine increases susceptibility to relapse in part by reducing cystine/glutamate exchange, and restoring exchanger activity prevents cocaine-primed drug seeking...
  37. pmc A cocaine cue acts as an incentive stimulus in some but not others: implications for addiction
    Benjamin T Saunders
    Department of Psychology, Biopsychology Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biol Psychiatry 67:730-6. 2010
    ..We asked, therefore, whether rats that have a propensity to attribute incentive salience to a food cue are the same ones that attribute incentive value to a drug (cocaine) cue...
  38. ncbi Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour
    B J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 153:17-30. 2000
    ....
  39. ncbi Cue dependency of nicotine self-administration and smoking
    A R Caggiula
    Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 70:515-30. 2001
    ....
  40. ncbi Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction
    J L Cornish
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 20:RC89. 2000
    ..These data suggest an important role for nucleus accumbens glutamate and not dopamine transmission in cocaine-induced relapse to drug-seeking behavior...
  41. pmc Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: a prospective, randomized, controlled trial
    Frederick L Altice
    Yale University AIDS Program, Yale University, New Haven, CT 06510 2283, USA
    Clin Infect Dis 45:770-8. 2007
    ..Directly administered antiretroviral therapy (DAART) is one approach to improve treatment adherence among human immunodeficiency virus (HIV)-infected drug users...
  42. ncbi The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats
    R E See
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 194:321-31. 2007
    ..Recent studies have implicated an important role for the dorsal striatum during craving for cocaine and in cocaine-seeking after abstinence in rats...
  43. ncbi A randomized, multicentre, open-label, parallel-group trial of the tolerability of interferon beta-1a (Rebif) administered by autoinjection or manual injection in relapsing-remitting multiple sclerosis
    D Mikol
    Department of Neurology, Multiple Sclerosis Center, University of Michigan, Ann Arbor, MI 48109 0588, USA
    Mult Scler 11:585-91. 2005
    ....
  44. pmc mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats
    Justin T Gass
    Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 34:820-33. 2009
    ....
  45. ncbi Injection anxiety remains a long-term barrier to medication adherence in multiple sclerosis
    Aaron P Turner
    VA Puget Sound Health Care System, Rehabilitation Care Service, S 117 RCS, 1660 S Columbian Way, Seattle, WA 98108, USA
    Rehabil Psychol 54:116-21. 2009
    ..Injection anxiety has been associated with medication discontinuation early in the course of treatment, but little is known about the relationship between injection anxiety and sustained DMT adherence over time...
  46. pmc The CASE adherence index: A novel method for measuring adherence to antiretroviral therapy
    S B Mannheimer
    Harlem Hospital Center, Columbia University, New York, NY, USA
    AIDS Care 18:853-61. 2006
    ..05). The CASE Adherence Index is an easy to administer instrument that provides an alternative method for assessing ART adherence in clinical settings...
  47. ncbi Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine
    Christina R Colby
    Division of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 23:2488-93. 2003
    ..These data suggest that accumulation of DeltaFosB contributes to drug addiction by increasing the incentive properties of cocaine, an effect that could increase the risk for relapse long after cocaine use ceases...
  48. ncbi Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice
    C Chiamulera
    Department of Biology, GlaxoSmithKline Laboratories, Via Fleming 4, 37100 Verona, Italy
    Nat Neurosci 4:873-4. 2001
    ..These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction...
  49. ncbi Correlation between serum ghrelin levels and cocaine-seeking behaviour triggered by cocaine-associated conditioned stimuli in rats
    Michela Tessari
    Department of Biology, Centre of Excellence for Drug Discovery in Psychiatry, Verona, Italy
    Addict Biol 12:22-9. 2007
    ..37; NS), and the increased active lever presses only in animals exposed to CS. These findings suggest a potential role of ghrelin in the modulation of cue-triggered reinstatement of cocaine-seeking behaviour...
  50. ncbi Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats
    U Shalev
    Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 156:98-107. 2001
    ..Finally, the time-dependent changes in footshock stress-induced reinstatement following withdrawal from heroin were not correlated with alterations in CRF mRNA in the CeA and BNST...
  51. ncbi Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys
    S R Letchworth
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    J Neurosci 21:2799-807. 2001
    ....
  52. pmc Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration
    S Pons
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 28:12318-27. 2008
    ....
  53. ncbi Suboptimal medication adherence in Parkinson's disease
    Katherine A Grosset
    Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom
    Mov Disord 20:1502-7. 2005
    ..In conclusion, poorer compliance is associated with younger age, depression, and more tablets per day, and one-fifth of PD patients underuse medication. Consideration of drug therapy adherence has implications in the management of PD...
  54. pmc Helping rural women in Pakistan to prevent postpartum hemorrhage: a quasi experimental study
    Ali Mohammad Mir
    Population Council, Islamabad, Pakistan
    BMC Pregnancy Childbirth 12:120. 2012
    ....
  55. ncbi Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychopharmacology 29:1190-202. 2004
    ..Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects...
  56. pmc Selective presynaptic enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine
    Anna Suska
    Molecular Neurobiology and Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, European Neuroscience Institute, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 110:713-8. 2013
    ..This presynaptic alteration may interact with other cocaine-induced cellular adaptations to shift the functional output of NAc neurons, contributing to the addictive emotional and motivational state...
  57. ncbi The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice
    Robyn M Brown
    Florey Neuroscience Institutes, University of Melbourne, Parkville, Victoria 3010, Australia
    Drug Alcohol Depend 123:264-8. 2012
    ..Collectively, these data implicate mGluR5 in the reinforcing effects of opiates and support the proposition that mGluR5 is a potential therapeutic target for treatment of drug addiction...
  58. ncbi Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Eur J Neurosci 19:1661-7. 2004
    ..Inactivation of the BLA had no effect on drug-seeking. These results are discussed with reference to critical and distinct contributions of the VTA, NAcc core and BLA to drug-seeking maintained by conditioned reinforcers..
  59. ncbi Deletion of CREB1 from the dorsal telencephalon reduces motivational properties of cocaine
    Cameron S McPherson
    Howard Florey Institute, University of Melbourne, Parkville, 3010 Victoria, Australia
    Cereb Cortex 20:941-52. 2010
    ..We conclude that there is a specific role for CREB1 in telencephalic glutamatergic neurons regulating the motivational properties of cocaine...
  60. pmc Where do young men want to access STI screening? A stratified random probability sample survey of young men in Great Britain
    John M Saunders
    Queen Mary University of London, Blizard Institute, Centre for Immunology and Infectious Disease Sexual Health and HIV, Barts Sexual Health Centre, St Bartholomew s Hospital, London EC1A 7BE, UK
    Sex Transm Infect 88:427-32. 2012
    ..The authors explored the acceptability of various medical, recreational and sports venues as settings to access self-collected testing kits for STIs and HIV among men in the general population and those who participate in sport...
  61. ncbi Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats
    Rita A Fuchs
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 176:459-65. 2004
    ..Thus, determination of the involvement of NAC subregions in conditioned cue-induced reinstatement of cocaine seeking is warranted...
  62. ncbi Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics
    Thomas J Martin
    Department of Anesthesiology, Wake Forest University School of Medicine, NC 27157, USA
    Anesthesiology 106:312-22. 2007
    ..The authors examined the pharmacology of self-regulated intake of opioids in rats with or without nerve injury and compared the rate of drug intake to reversal of allodynia...
  63. pmc Endogenous BDNF in the dorsolateral striatum gates alcohol drinking
    Jerome Jeanblanc
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 29:13494-502. 2009
    ..Importantly, our results suggest that an endogenous signaling pathway within the same brain region that mediates drug-taking behavior also plays a critical role in gating the level of ethanol intake...
  64. ncbi Increases in dopamine D3 receptor binding in rats receiving a cocaine challenge at various time points after cocaine self-administration: implications for cocaine-seeking behavior
    Janet L Neisewander
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Neuropsychopharmacology 29:1479-87. 2004
    ..Collectively, the findings suggest that regulatory responses of D3 receptors may be functionally related to changes in propensity for cocaine-seeking behavior...
  65. ncbi Expanding uterotonic protection following childbirth through community-based distribution of misoprostol: operations research study in Nepal
    Swaraj Rajbhandari
    Options Cambodia
    Int J Gynaecol Obstet 108:282-8. 2010
    ..To determine feasibility of community-based distribution of misoprostol for preventing postpartum hemorrhage (PPH) to pregnant woman through community volunteers working under government health services...
  66. pmc Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration
    Claire I Dixon
    School of Psychology, University of Sussex, Brighton, United Kingdom
    PLoS ONE 7:e47135. 2012
    ..However, no change was observed in ethanol self administration, suggesting the rewarding effects of ethanol remain unchanged.
  67. ncbi Misoprostol for preventing and treating postpartum hemorrhage in the community: a closer look at the evidence
    Olufemi T Oladapo
    Maternal and Fetal Health Research Unit, Department of Obstetrics and Gynecology, Olabisi Onabanjo University Teaching Hospital, P M B 2001, Sagamu, Ogun State, Nigeria
    Int J Gynaecol Obstet 119:105-10. 2012
    ..It is time for the international community to focus on improving PPH-related outcomes by scaling up what is currently guided by hard evidence and join forces to address unanswered questions through high-quality research...
  68. ncbi The cannabinoid CB1 antagonist N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methylpyrazole-3-carboxamide (SR-141716A) differentially alters the reinforcing effects of heroin under continuous reinforcement, fixed ratio, and progressive ratio
    M Solinas
    Preclinical Pharmacology Section, Neuroscience Research Branch, National Institute on Drug Abuse, Division of Intramural Research, National Institutes of Health, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 306:93-102. 2003
    ..These findings indicate a facilitatory modulation of opioid reward by endogenous cannabinoid activity and provide support for the use of cannabinoid CB1 antagonists as medications for heroin addiction...
  69. ncbi Effects of serotonin (5-HT)6 receptor ligands on responding for cocaine reward and seeking in rats
    Katarzyna Fijał
    Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 62:1005-14. 2010
    ..WAY 181187 at the highest dose used (30 mg/kg) reduced basal locomotor activity. Despite current results, the precise function and therapeutic relevance of 5-HT(6) receptors need further clarification...
  70. pmc Distinct contributions of dopamine in the dorsolateral striatum and nucleus accumbens shell to the reinforcing properties of cocaine
    Maartje M J Veeneman
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 37:487-98. 2012
    ..We suggest that the DLS and the NAcc shell mediate somewhat distinct facets of the reinforcing properties of cocaine, related to its rewarding and motivational aspects, respectively...
  71. pmc Role of individual and developmental differences in voluntary cocaine intake in rats
    Nicole L Schramm-Sapyta
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 215:493-504. 2011
    ..Here, a rodent model is used to explore the causality of early onset in development of self-administration and addiction-like behavior and to examine factors that promote self-administration...
  72. ncbi Prevention and treatment of drug addiction by environmental enrichment
    Marcello Solinas
    Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, CNRS 6187, Pôle Biologie Santeé, 1 Rue George Bonnet, Bat 633, Poitiers 86022, France
    Prog Neurobiol 92:572-92. 2010
    ..This theoretical framework highlights the importance of stress in each phase of drug addiction and strongly suggests that life conditions of abstinent addicts should be considered as part of their treatment...
  73. pmc Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice
    Lene S Schmidt
    Laboratory of Neuropsychiatry, Rigshospitalet University Hospital, Copenhagen, Denmark
    Psychopharmacology (Berl) 216:367-78. 2011
    ..Behavioral and neurochemical studies have shown that the cholinergic muscarinic M(4) receptor subtype plays an important role in regulation of dopaminergic neurotransmission...
  74. pmc Extracellular fluctuations of dopamine and glutamate in the nucleus accumbens core and shell associated with lever-pressing during cocaine self-administration, extinction, and yoked cocaine administration
    Nobuyoshi Suto
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 211:267-75. 2010
    ..Dopamine and glutamate in the nucleus accumbens (NAS) are differentially implicated in cocaine-directed behavior...
  75. ncbi The Roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction, and reinstatement of intravenous cocaine self-administration
    Liana Fattore
    Institute of Neuroscience CNR, Section of Cagliari, Italy
    Neuropsychopharmacology 34:1091-101. 2009
    ....
  76. pmc Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration
    K L Conrad
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neuroscience 169:182-94. 2010
    ....
  77. ncbi Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement
    Cecilia Gotti
    Department of Medical Pharmacology, Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Cellular and Molecular Pharmacology Center, University of Milan, 20129 Milan, Italy
    J Neurosci 30:5311-25. 2010
    ....
  78. ncbi Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens
    Devadoss J Samuvel
    Division of Neuroscience Research, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 325:293-301. 2008
    ....
  79. pmc Psychomotor stimulant effects of cocaine in rats and 15 mouse strains
    Morgane Thomsen
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Mail Stop 214, 115 Mill Street, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 19:321-41. 2011
    ..Additionally, these results should aid in selecting mouse strains for future studies in which relative locomotor responsiveness to psychostimulants is a necessary consideration...
  80. ncbi D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement
    A A Bari
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, L 603, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Neuroscience 135:959-68. 2005
    ....
  81. ncbi Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:5881-7. 2006
    ..Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction...
  82. ncbi Strain differences in the dose-response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats
    Carmen García-Lecumberri
    Psychobiology Department, School of Psychology, UNED, Madrid, Spain
    J Psychopharmacol 25:783-91. 2011
    ....
  83. ncbi Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction
    Benoit Forget
    Translational Addiction Research Laboratory, Pharmacology and Psychiatry, Institutes of Medical Sciences, University of Toronto, Toronto, Canada
    Biol Psychiatry 68:265-71. 2010
    ..However, the effect of an inactivation of this structure in an animal model of nicotine addiction has yet to be evaluated...
  84. pmc Impulsivity predicts the escalation of cocaine self-administration in rats
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Pharmacol Biochem Behav 93:343-8. 2009
    ..This study suggests that individual differences in impulsivity predict escalation of cocaine self-administration in female rats, which may have implications in the prediction of binge-like patterns of cocaine intake in women...
  85. pmc Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 196:207-13. 2009
    ....
  86. ncbi Acquisition of nicotine self-administration in adolescent rats given prolonged access to the drug
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 32:700-9. 2007
    ..However, adolescent females acquired the behavior more rapidly and attained higher levels of stable nicotine SA than adults...
  87. pmc Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice
    Yuri A Blednov
    Waggoner Center for Alcohol and Addictions Research, University of Texas, Austin, TX 78712 0159, USA
    Alcohol Clin Exp Res 29:1949-58. 2005
    ..No strain has been found to consume more ethanol than B6. In one of our laboratories (Texas), we noted a markedly greater intake of ethanol in an F1 hybrid of B6 and FVB/NJ (FVB) mice...
  88. pmc Forced abstinence model of relapse to study pharmacological treatments of substance use disorder
    Carmela M Reichel
    Department of Psychology, University of Nebraska Lincoln, Lincoln NE 68588 0308, USA
    Curr Drug Abuse Rev 2:184-94. 2009
    ....
  89. ncbi Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in rats
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 180:258-66. 2005
    ....
  90. ncbi Dissociation between rewarding and psychomotor effects of opiates: differential roles for glutamate receptors within anterior and posterior portions of the ventral tegmental area
    Maytal Shabat-Simon
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 28:8406-16. 2008
    ..These findings suggest a critical role for glutamate receptors in the VTA in opiate reward, as well as behavioral and anatomical dissociation between the rewarding and psychomotor effects of opiates...
  91. ncbi Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: evidence for involvement of dopamine neurons
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 24:1050-7. 2004
    ..The results of this study indicate that EtOH is reinforcing within the posterior VTA of male Wistar rats and suggest that activation of VTA DA neurons is involved in this process...
  92. pmc Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues
    Kathryn A Cunningham
    Center for Addiction Research, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77550 0615, USA
    Neuropharmacology 61:513-23. 2011
    ....
  93. ncbi 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism
    Donald R Gehlert
    Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 27:2718-26. 2007
    ..Based on these findings, MTIP is a promising candidate for treatment of alcohol dependence...
  94. pmc Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine
    Ghazaleh Sadri-Vakili
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129 4404, USA
    J Neurosci 30:11735-44. 2010
    ....
  95. pmc Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats
    Susmita Chatterjee
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    Neuropsychopharmacology 36:603-15. 2011
    ..CP-601932 has been shown to be safe in humans and may represent a potential novel treatment for AUDs...
  96. ncbi Strain differences in maintenance of cocaine self-administration and their relationship to novelty activity responses
    Therese A Kosten
    Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Behav Neurosci 121:380-8. 2007
    ..Maintenance studies of cocaine self-administration rather than acquisition may better reflect vulnerability to addiction...
  97. pmc Effect of environmental enrichment on escalation of cocaine self-administration in rats
    Cassandra D Gipson
    Center for Drug Abuse Research Translation CDART, University of Kentucky, 741 S Limestone, Lexington, KY 40536 0509, USA
    Psychopharmacology (Berl) 214:557-66. 2011
    ..Previous studies found that environmental enrichment protects against the initiation of stimulant self-administration in rats, but it is unclear if enrichment also protects against the escalation of stimulant use with long-term exposure...
  98. ncbi Nicotine self-administration in animals as a dependence model
    W A Corrigall
    Biobehavioural Research Department, University of Toronto, Canada
    Nicotine Tob Res 1:11-20. 1999
    ..Two examples of ongoing studies of the mechanisms of dependence are discussed: the role of cholinergic projections to midbrain dopamine cells, and the influence of opioid receptors in the vicinity of these same dopamine cells...
  99. ncbi Rats prefer cocaine over nicotine in a two-lever self-administration choice test
    A M Manzardo
    College of Medicine, Department of Pharmacology, University of California Irvine, Irvine, CA 92697 4625, USA
    Brain Res 924:10-9. 2002
    ..It is possible that dependence elevates nicotine's reward magnitude or nicotine addiction may rely more importantly upon negative rather than pure positive reinforcement...
  100. ncbi The suppressive effect of an intra-prefrontal cortical infusion of BDNF on cocaine-seeking is Trk receptor and extracellular signal-regulated protein kinase mitogen-activated protein kinase dependent
    Timothy W Whitfield
    Department of Neurosciences and Neurobiology of Addiction Research Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 31:834-42. 2011
    ....
  101. ncbi A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats
    William J Berglind
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur J Neurosci 26:757-66. 2007
    ....

Research Grants80

  1. Neurochemistry of Cocaine Reinforcement
    NICHOLAS GOEDERS; Fiscal Year: 2002
    ..These results will also provide evidence of the role that is played by steroid hormones in shaping the functional activity of the brain. ..
  2. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
    ..abstract_text> ..
  3. Sex Steroid Hormone Regulation of Drug Reinforcement
    Diane Lebesgue; Fiscal Year: 2012
    ..I will be assisted by my primary mentor Dr. Saleem Nicola to properly design and carry out cocaine self administration experiments. My co- mentor, Dr...
  4. Histone Methylation: a role in excessive ethanol intake and self-administration
    Jennifer A Rinker; Fiscal Year: 2012
    ..Results from the proposed research will help elucidate the mechanisms underlying alcohol-induced neuroplastic changes and provide insight into the development of more targeted treatment and prevention strategies. ..
  5. Preclinical studies of a heroin/morphine vaccine for opiate addiction
    Paul R Pentel; Fiscal Year: 2013
    ....
  6. Developing Immunotherapeutics for Methamphetamine Abuse
    THOMAS RICHARD KOSTEN; Fiscal Year: 2010
    ..Orson and Kinsey have been working on the development of DMA vaccines. Our group's combined experience is ideally positioned to get a vaccine quickly into phase 1 human studies. ..
  7. Multivalent Vaccine for Opiate Addiction
    Paul R Pentel; Fiscal Year: 2012
    ..abstract_text> ..
  8. Vaccines for Sustainable Therapy of Opiate Addiction
    Frank M Orson; Fiscal Year: 2012
    ..opiate associated analgesia will also block heroin induced locomotor activity and reinstatement of heroin self administration in the rat model...
  9. Neuroplasticity with alcohol dependence
    Scott C Steffensen; Fiscal Year: 2013
    ....
  10. Treatment of Acute Coronary Syndromes with Recombinant LCAT Infusion
    BRIAN ROBERT KRAUSE; Fiscal Year: 2011
    ....
  11. Sex and Stress Mechanisms of Vulnerability to Addiction
    Rajita Sinha; Fiscal Year: 2011
    ..Together our studies will clarify the relationship and potential converging effects of sex and stress on VTA functioning in vulnerability to addiction. ..
  12. Development of Inhaled Vancomycin for Treatment of MRSA Infections in CF
    Taneli Jouhikainen; Fiscal Year: 2012
    ..is developing a much safer inhaled dry-powder form of vancomycin (AEROVANC) for the local treatment of MRSA infections, which is intended for convenient, low cost self-administration at home. ..
  13. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    DIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2013
    ..Our experiments thus model one aspect of the eating habits of people in 'Westernized'societies such as the U.S. and may provide translational insight into dealing with this excessive intake. ..
  14. Neurobiological mechanisms of nicotine reinforcement: Role of the nucleus tractus
    LUIS MIGUEL TUESTA; Fiscal Year: 2012
    ..Results from the experiments outlined in this proposal will increase our basic understanding of nicotine addiction, and may provide exciting targets for the development of novel therapeutics for smoking cessation. ..
  15. Persistent Attenuation of Cocaine-Reinforced Behavior
    KENNETH W GRASING; Fiscal Year: 2013
    ..Aversive effects of cocaine will be assessed by allowing rats to make mutually-exclusive choices for drug or food reinforcement and measuring their proximity to levers used to obtain either reinforcer. ..
  16. Anabolic-androgenic steroids enhance motivation
    Ruth I Wood; Fiscal Year: 2013
    ....
  17. Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic Measures
    KENNETH W GRASING; Fiscal Year: 2012
    ..To evaluate the occurrence of persistent attenuation, the subjective and reinforcing effects of intravenous cocaine will be determined during oral treatment and three days following its discontinuation. ..
  18. CRF and Stress Modulation of Phasic Dopamine Release and Behavior
    MATTHEW J WANAT; Fiscal Year: 2013
    ....
  19. Development of a Human Hydrolase to Treat Cocaine Abuse and Overdose: Rat Models
    WILLIAM STEPHEN BRIMIJOIN; Fiscal Year: 2011
    ..This application will investigate whether direct treatment or gene therapy with this enzyme can reduce drug-seeking behavior in rats as a model for cocaine addiction in humans. ..
  20. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2013
    ..These studies will lead to a better understanding of how the circadian genes are involved in regulating the dopaminergic reward pathway and the development of cocaine addiction. ..
  21. Mechanisms of regulation of ethanol intake by lateral habenula
    Jiang Hong Ye; Fiscal Year: 2013
    ..These studies could also provide insight into the cellular mechanisms governing negative reinforcement-associated drinking in human alcoholics. ..
  22. Prenatal Cannabis Exposure and Epigenetic Mechanisms Underlying Vulnerability to
    CLAUDIA VARGAS MORRIS; Fiscal Year: 2013
    ....
  23. Functional genetic evolution of human brain and behavior
    Eric J Vallender; Fiscal Year: 2013
    ..This work will allow us to better understand how the human brain works, what goes wrong in neuropsychiatric disorders and ways in which we might develop better animal models for studying human disease. ..
  24. Repurposing cholinesterase inhibitors for smoking cessation
    REBECCA ASHARE; Fiscal Year: 2013
    ..This comprehensive, interdisciplinary mentored approach will enhance my clinical research skills and my ability to compete successfully for R01 funding and establish an independent program of research. ..
  25. Sex/Gender Factors in Nicotine Addiction
    Nancy K Mello; Fiscal Year: 2012
    ....
  26. Development of a5* nAChR positive allosteric modulators for tobacco dependence
    JON MARTIN LINDSTROM; Fiscal Year: 2013
    ..If successful, this program of research promises to have a significant positive impact on human health. ..
  27. Regulation of Cocaine Reward and Reinforcement by MeCP2
    ANNE ELIZABETH WEST; Fiscal Year: 2013
    ..These studies promise to yield significant new insights into the neurobiological mechanisms that impact susceptibility to cocaine addiction. ..
  28. An RCT of telemedicine interventions for OSA
    DAVID W SPARROW; Fiscal Year: 2013
    ..abstract_text> ..
  29. The Role of CLOCK in Ethanol-Related Behaviors
    Angela Renee Ozburn; Fiscal Year: 2012
    ..The funding of this NRSA application is instrumental in my success. ..
  30. mGluR5 antagonists for methamphetamine addiction
    M Foster Olive; Fiscal Year: 2012
    ....
  31. Ethanol Dependence and Kappa Receptor Antagonists
    MARC REZA AZAR; Fiscal Year: 2011
    ..The potential commercial application of the work is that the research could lead to a "blockbuster" drug product. ..
  32. GCs, CRF and Stressor-Induced Relapse
    John R Mantsch; Fiscal Year: 2013
    ..The ability of a rat model of excessive drug use to enhance CRF regulation of drug-seeking behavior in a manner that depends on secretion of glucocorticoid hormones will be tested. ..
  33. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2012
    ..The goal of this research is to better understand the biological basis of the disease, and to identify major biological targets for potential therapeutic intervention to promote abstinence. ..
  34. Sex Differences in Vulnerability to Cocaine Addiction
    Therese Kosten; Fiscal Year: 2009
    ..Studies in this competitive revision will test the hypothesis that these sex differences are due to sex-dependent differences in maternal care received and reflect epigenetic effects of targeted genes in select brain regions. ..
  35. Drug Abuse: Sex differences in developmental and environmental influences
    Jill B Becker; Fiscal Year: 2010
    ..Results from these experiments will have implications for treatment and prevention of drug abuse using non-pharmacological interventions. ..
  36. Vaccines for the Treatment of Opiate Addiction
    Kim D Janda; Fiscal Year: 2013
    ..Successful completion of these studies could provide an alternative strategy for treatment of opiate addiction and also for HIV prevention. ..
  37. Beta-lactam chemical probes for GLT-1 transporter-related pathologies
    Scott M Rawls; Fiscal Year: 2010
    ....
  38. Illness Management and Recovery Program: IMR-Web
    JAMES P O apos HALLORAN; Fiscal Year: 2010
    ..IMR-Web will lead to more rapid, cost-effective adoption of the powerful and comprehensive IMR program. ..
  39. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2011
    ..Such studies will identify novel therapeutic targets for the treatment of nicotine dependence and habitual tobacco smoking in humans. ..
  40. Molecular Regulation of GABA(A) Receptor Function in Amygdala
    Kerry J Ressler; Fiscal Year: 2010
    ..Understanding the mechanisms shared by stress and drug response is critical for understanding pathophysiology and proposing new treatments for these highly comorbid disorders. ..
  41. Drug Discovery for Cognitive Impairment Associated with Drugs of Abuse
    Alvin V Terry; Fiscal Year: 2013
    ..In addition to cognitive improvement, choline analogs could also prevent the neural toxicity associated with the chronic abuse of several addictive substances. ..
  42. p38 MAPK Mechanisms of Kappa Opioid-Induced Aversion
    Charles Chavkin; Fiscal Year: 2013
    ....
  43. Melanocortin Neuropeptides &Ethanol Intake
    Todd E Thiele; Fiscal Year: 2013
    ..The work that is outlined in the current proposal will show that melanocortin neuropeptides modulate the reinforcing properties of alcohol and relapse of alcohol-seeking behavior following abstinence. ..
  44. Nicotine delivery to rodent with lung alveolar region-targeted aerosol technology
    Xinmin Simon Xie; Fiscal Year: 2013
    ..Furthermore, the significant potential for these toolkits to be used for other drugs of abuse such as marijuana, cocaine, and heroin will expand the market size for our products. ..
  45. A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits
    KAY MAXINE TYE; Fiscal Year: 2013
    ..Third, this proposal heavily leverages my unique background in sucrose-self administration, relapse, optogenetics, electrophysiology and imaging, but is technically and conceptually distinct from my ..
  46. Chemistry and Biology of 5-HT2C Receptor Ligands for Drug Abuse
    ALAN PAUL KOZIKOWSKI; Fiscal Year: 2010
    ....
  47. Catalytic Approach to Treatment of Cyanide Poisoning
    SIGRIDUR G SUMAN; Fiscal Year: 2010
    ..Cyanide is a serious health hazard in building fires and as an industrial hazard, and an efficient mass treatment for cyanide poisoning is lacking. ..
  48. Genetic Basis of Opioid Reward and Aversion in Mice
    Camron D Bryant; Fiscal Year: 2012
    ..I am also interested in the intersection between reward/aversion and pain pathways and would like to further explore this area of research as a future application. ..
  49. Genetic Basis of Opioid Reward and Aversion in Mice
    Camron D Bryant; Fiscal Year: 2013
    ..I am also interested in the intersection between reward/aversion and pain pathways and would like to further explore this area of research as a future proposal. ..
  50. Monoacylglycerol Lipase Inhibitors for Treating Opioid Use Disorders
    Aron H Lichtman; Fiscal Year: 2013
    ....
  51. GENETIC VULNERABILITY TO DRUGS OF ABUSE
    Kari J Buck; Fiscal Year: 2013
    ..This can direct further mechanistic studies and elucidate the important network(s), within which many biomarkers and drugable targets may exist to direct translational studies. ..
  52. Neurosteroid-BZ combinations: Strategy for reducing abuse and sedation
    James K Rowlett; Fiscal Year: 2013
    ..The ultimate goal for this research program is to provide critical preclinical information for development of a broadly effective combination product with an improved side effect profile for treating anxiety disorders. ..
  53. Reversal of AMPA receptor plasticity underlying incubation of cocaine craving
    MARINA ELIZABETH WOLF; Fiscal Year: 2013
    ..g., drug taking, arousal, provide a novel arena for medication development. Improved medications for drug abuse will have immediate clinical impact. ..
  54. A Novel Compound for Alcoholism Treatment: a Translational Strategy
    Lorenzo Leggio; Fiscal Year: 2013
    ..In summary, this research will investigate the tolerability, efficacy and mechanism of this novel pharmacological approach for AD thus leading to the potential identification of a new treatment for AD. ..
  55. Determinants of Nicotine Reinforcement Thresholds and Demand Elasticity in Rats
    Mark G LeSage; Fiscal Year: 2013
    ..As such, the present study could contribute to the scientific basis for evaluation of reduced nicotine tobacco products and their clinical and public health consequences. ..
  56. Implantable Minipump For Tetherless Drug Self-Administration In Mice
    DANIEL PHILIPP HOLSCHNEIDER; Fiscal Year: 2010
    ..Its application in transgenic mouse models will allow examination of gene x environment interactions, which are crucial to the interpretation of the range and limits of genetic influences on addictive behaviors in human subjects. ..
  57. Influenza vaccination using a microneedle patch
    Mark R Prausnitz; Fiscal Year: 2013
    ..The proposed Phase I clinical trial will provide the first human study of this technology. ..
  58. Synaptic and Behavioral Correlates of Early Life Stress in the BLA
    Mary Jane Skelly; Fiscal Year: 2013
    ....
  59. Targeted Library Synthesis and Screening: Allosteric Modulators of Transporters
    Subramaniam Ananthan; Fiscal Year: 2013
    ..These studies should reveal the potential of the allosteric ligands of DAT as treatment agents for substance abuse and psychiatric disorders. ..
  60. Uncertainty and stimulant self-administration
    PAUL R VEZINA; Fiscal Year: 2013
    ....
  61. Molecular mechanisms of excessive alcohol consumption and relapse-like behavior
    REGINALD DEVON CANNADY; Fiscal Year: 2012
    ..to phosphorylate GluR1 and enhance AMPAR activity) by blocking aniracetam-induced effects during self administration and reinstatement sessions with KN93 (CamKII inhibitor)...
  62. Ethanol Regulation of Neuronal Nicotinic Receptor Expression in Reward Circuitry
    Andrew R Tapper; Fiscal Year: 2010
    ..The insights gained from this project should help elucidate the molecular mechanism underlying alcoholism, as well as identify molecular targets for alcohol cessation therapeutics. ..
  63. CB1 and DA Receptor Deletion by RNAi in Cocaine Self-Administration
    CAROLINE EVELYN BASS; Fiscal Year: 2011
    ..These findings may lead to the development of novel and more effective therapeutic interventions for drug addiction. ..
  64. ENVIRONMENTAL AND PHARMACOLOGICAL CONTROL OF DRUG ABUSE
    Marilyn Carroll; Fiscal Year: 2000
    ....
  65. DRUG SELF-ADMINISTRATION BY INHALATION IN THE PRIMATE
    Ronald Wood; Fiscal Year: 1991
    ....
  66. NUCLEUS ACCUMBENS INVOLVEMENT IN COCAINE REINFORCEMENT
    GREGORY MARK; Fiscal Year: 2002
    ..It is hoped that these results will further our understanding of the involvement of cholinergic mechanisms in drug-seeking and potentially to the development of clinically efficacious treatments for drug craving and relapse. ..
  67. STIMULANTS, DEPRESSANTS & HALLUCINOGENS AS REINFORCERS
    Gail Winger; Fiscal Year: 2003
    ..These drugs can be those that the WHO or the FDA is considering for scheduling decisions, drugs made by industrial or academic medicinal chemists, or industrial drugs that are being considered for clinical testing. ..
  68. Effects of Negative Consequences on Drug Self Administration in Rats
    Jerry B Richards; Fiscal Year: 2010
    ..provided by applicant): The primary objective of the proposed research is to develop a rodent model of self administration (SA) in which drug consumption has delayed negative consequences...
  69. PHYSIOLOGY OF CNS MONOAMINES AND DRUGS OF ABUSE
    Donald Woodward; Fiscal Year: 1999
    ..This research program is designed to yield a comprehensive clarification of neuron population spike train activity in the mesolimbic brain reward system during behaviors for drug self-administration reinforcement. ..
  70. COCAINE SELF-ADMINISTRATION/PHYSIOLOGICAL MEASURES
    Srihari Tella; Fiscal Year: 1999
    ..These studies should also aid in the preclinical safety evaluation of drugs that are proposed for the treatment of cocaine addiction. ..
  71. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2003
    ....
  72. Hallucinogen self-administration in baboons
    AMY GOODWIN; Fiscal Year: 2009
    ..An examination of the reinforcing effects of LSD in baboons is clinically relevant to the therapeutic use of these compounds, as well as the potential treatment for the abuse of these compounds. ..
  73. VTA Ionotropic Glutamate Receptors in Cocaine Addiction
    David Self; Fiscal Year: 2009
    ....
  74. Lipid biosignatures of drug addiction
    Daniele Piomelli; Fiscal Year: 2010
    ....
  75. Drugs of Abuse, Gender Differences, and Protection by Sweets
    Angie Cason; Fiscal Year: 2010
    ....
  76. Infralimbic Regulation of Memory Consolidation of Extinction of Cocaine-seeking
    Ryan T Lalumiere; Fiscal Year: 2010
    ..This research will have a significant impact on public health as the extinction process is a potential pharmacotherapeutic target in the treatment of drug addiction. ..
  77. PAVLOVIAN MEDIATION OF DRUG SELF-ADMINISTRATION
    Christopher Cunningham; Fiscal Year: 1991
    ..This understanding should help us to recognize increased risk of drug abuse, to devise more efficient and effective treatments for drug addiction and to outline more effective prevention strategies...
  78. Nicotine Self-Administration: Tobacco Pharmacotherapies
    MATTHEW PALMATIER; Fiscal Year: 2009
    ....
  79. Agmatinergic Control of Opioid Tolerance and Drug Abuse
    CAROLYN FAIRBANKS; Fiscal Year: 2003
    ..abstract_text> ..
  80. Opioid Self-Administration in Chronic Pain
    CAROLYN FAIRBANKS; Fiscal Year: 2009
    ..Modeling opioid self- administration in mice experiencing chronic pain will provide insight into this concept and ultimately improve patient access to opioid therapy for their pain. ..