estrogen replacement therapy

Summary

Summary: The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.

Top Publications

  1. ncbi Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    Jacques E Rossouw
    Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
    JAMA 288:321-33. 2002
  2. ncbi Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States)
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Causes Control 13:741-51. 2002
  3. ncbi Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial
    Sally A Shumaker
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27104, USA
    JAMA 289:2651-62. 2003
  4. ncbi Endometrial cancer and hormone-replacement therapy in the Million Women Study
    Valerie Beral
    Lancet 365:1543-51. 2005
  5. ncbi Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004
  6. ncbi A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy
    M G Glazier
    Department of Family Practice and Community Medicine, University of Pennsylvania, Second Floor, Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arch Intern Med 161:1161-72. 2001
  7. ncbi Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin
    R K Ross
    University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9181, USA
    J Natl Cancer Inst 92:328-32. 2000
  8. ncbi Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women
    S R Salpeter
    Stanford University School of Medicine, Stanford, CA, USA
    Diabetes Obes Metab 8:538-54. 2006
  9. ncbi Estrogen replacement therapy and retinal vascular caliber
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 112:553-8. 2005
  10. ncbi Treatment of menopausal symptoms: what shall we do now?
    Martha Hickey
    University of Western Australia, School of Women s and Infants Health, King Edward Memorial Hospital, Subiaco, Western Australia 6008, Australia
    Lancet 366:409-21. 2005

Detail Information

Publications284 found, 100 shown here

  1. ncbi Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    Jacques E Rossouw
    Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
    JAMA 288:321-33. 2002
    ..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain...
  2. ncbi Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States)
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Causes Control 13:741-51. 2002
    ....
  3. ncbi Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial
    Sally A Shumaker
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27104, USA
    JAMA 289:2651-62. 2003
    ..On July 8, 2002, the study drugs, estrogen plus progestin, in the Women's Health Initiative (WHI) trial were discontinued because of certain increased health risks in women receiving combined hormone therapy...
  4. ncbi Endometrial cancer and hormone-replacement therapy in the Million Women Study
    Valerie Beral
    Lancet 365:1543-51. 2005
    ..To minimise this risk, many HRT users who have not had a hysterectomy use combined oestrogen-progestagen preparations or tibolone. Limited information is available on the incidence of endometrial cancer in users of these therapies...
  5. ncbi Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004
    ..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain...
  6. ncbi A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy
    M G Glazier
    Department of Family Practice and Community Medicine, University of Pennsylvania, Second Floor, Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arch Intern Med 161:1161-72. 2001
    b>Estrogen replacement therapy (ERT) is recommended for postmenopausal women primarily for reduction of menopausal symptoms and prevention of osteoporosis and cardiovascular disease...
  7. ncbi Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin
    R K Ross
    University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9181, USA
    J Natl Cancer Inst 92:328-32. 2000
    Hormone replacement therapy (HRT) given as unopposed estrogen replacement therapy (ERT) gained widespread popularity in the United States in the 1960s and 1970s. Recent prescribing practices have favored combination HRT (CHRT), i.e...
  8. ncbi Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women
    S R Salpeter
    Stanford University School of Medicine, Stanford, CA, USA
    Diabetes Obes Metab 8:538-54. 2006
    ..To quantify the effects of hormone-replacement therapy (HRT) on components of the metabolic syndrome in postmenopausal women...
  9. ncbi Estrogen replacement therapy and retinal vascular caliber
    Tien Yin Wong
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Ophthalmology 112:553-8. 2005
    It is unclear if estrogen replacement therapy (ERT) has an effect on the retinal circulation. In the current study, we examine the association of ERT, female reproductive factors, and retinal vascular caliber.
  10. ncbi Treatment of menopausal symptoms: what shall we do now?
    Martha Hickey
    University of Western Australia, School of Women s and Infants Health, King Edward Memorial Hospital, Subiaco, Western Australia 6008, Australia
    Lancet 366:409-21. 2005
    ..There is not enough evidence that any of the complementary therapies available are any better than placebo for menopausal vasomotor symptoms, and few safety data exist...
  11. pmc Changing concepts: Menopausal hormone therapy and breast cancer
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor, UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    J Natl Cancer Inst 104:517-27. 2012
    ..Currently, the different effects of estrogen plus progestin vs estrogen alone on breast cancer are not completely understood...
  12. ncbi Menopause
    Heidi D Nelson
    Oregon Evidence Based Practice Center, Department of Medical Informatics and Clinical Epidemiology, OR, USA
    Lancet 371:760-70. 2008
    ..Many questions about menopausal transition and its effects on health have not been adequately addressed...
  13. pmc Estrogen plus progestin therapy and breast cancer in recently postmenopausal women
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 167:1207-16. 2008
    ..64 (95% confidence interval: 1.00, 2.68) over a 5-year period of use and 2.19 (95% confidence interval: 1.56, 3.08) over a 10-year period of use...
  14. ncbi 17beta-estradiol attenuates the development of pressure-overload hypertrophy
    M van Eickels
    Cardiovascular Research Institute Maastricht, University of Maastricht, Netherlands
    Circulation 104:1419-23. 2001
    ..Epidemiological studies indicate that estrogen replacement therapy is cardioprotective; the mechanisms involved in this process, however, are poorly understood...
  15. ncbi Estrogen receptors: new players in diabetes mellitus
    Rodrigo P A Barros
    Department of Biosciences and Nutrition, Karolinska Institute, S 141 86 Novum, Sweden
    Trends Mol Med 12:425-31. 2006
    ..Drugs that can selectively modulate the activity of either ERalpha or ERbeta in their interactions with target genes represent a promising frontier in diabetes mellitus coadjuvant therapy...
  16. pmc Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Brain Res 1379:188-98. 2011
    ..Therefore, women who underwent bilateral oophorectomy before the onset of menopause or women who experienced premature or early natural menopause should be considered for hormonal treatment until approximately age 51 years...
  17. pmc Breast cancer risk in relation to the interval between menopause and starting hormone therapy
    Valerie Beral
    University of Oxford, Oxford, OX3 7LF, UK
    J Natl Cancer Inst 103:296-305. 2011
    ..We investigated whether the timing of these therapies affected breast cancer incidence...
  18. pmc Using basic science to design a clinical trial: baseline characteristics of women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)
    V M Miller
    Medical Science 4 62, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Cardiovasc Transl Res 2:228-39. 2009
    ..KEEPS will provide information relevant to the critical timing hypothesis for MHT use in reducing risk for CVD...
  19. pmc Breast cancer after use of estrogen plus progestin in postmenopausal women
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    N Engl J Med 360:573-87. 2009
    ..Subsequently, the incidence of breast cancer also dropped, suggesting a cause-and-effect relation between hormone treatment and breast cancer. However, the cause of this decrease remains controversial...
  20. ncbi Effect of estrogen on calcium-handling proteins, beta-adrenergic receptors, and function in rat heart
    Sang Hui Chu
    Department of Clinical Nursing Science, Yonsei University, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Life Sci 79:1257-67. 2006
    ..However, hormone-dependent alterations in protein were not associated with changes in contractile function...
  21. ncbi National use of postmenopausal hormone therapy: annual trends and response to recent evidence
    Adam L Hersh
    Stanford Prevention Research Center, Program on Prevention Outcomes and Practices, Stanford University School of Medicine, Stanford, Calif 94305, USA
    JAMA 291:47-53. 2004
    ..Recent evidence from randomized trials published in July 2002 demonstrated adverse cardiovascular disease events and other risks with hormone therapy in the form of oral estrogen combined with progestin...
  22. ncbi Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy?
    V Beck
    Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
    J Steroid Biochem Mol Biol 94:499-518. 2005
    ..Currently 40-50mg of isoflavones (biochanin A, daidzein, formononetin and genistein) are recommended as daily dose. This recommendation is based on the daily intake of phytoestrogens in a traditional Japanese diet...
  23. ncbi Estrogen therapy in postmenopausal women: effects on cognitive function and dementia
    K Yaffe
    Department of Psychiatry, University of California, San Francisco 94121, USA
    JAMA 279:688-95. 1998
    Several studies have suggested that estrogen replacement therapy in postmenopausal women improves cognition, prevents development of dementia, and improves the severity of dementia, while other studies have not found a benefit of estrogen ..
  24. ncbi A clinical trial of estrogen-replacement therapy after ischemic stroke
    C M Viscoli
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn. 06520-8056, USA
    N Engl J Med 345:1243-9. 2001
    ..CONCLUSIONS: Estradiol does not reduce mortality orthe recurrence of stroke in postmenopausal women with cerebrovascular disease. This therapy should not be prescribed for the secondary prevention of cerebrovascular disease...
  25. ncbi Biology of estrogens in skin: implications for skin aging
    Sylvie Verdier-Sévrain
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    Exp Dermatol 15:83-94. 2006
    ..These drugs exert mixed estrogenic and antiestrogenic effects depending on the tissue and cell type. One might expect in the future such a drug targeting specifically the skin without systemic side effects...
  26. ncbi Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study
    Terry Young
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726 2335, USA
    Am J Respir Crit Care Med 167:1181-5. 2003
    ..Evaluation for sleep-disordered breathing should be a priority for menopausal women with complaints of snoring, daytime sleepiness, or unsatisfactory sleep...
  27. ncbi Lifetime alcohol consumption and postmenopausal breast cancer rate in Denmark: a prospective cohort study
    Anne Tjønneland
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    J Nutr 134:173-8. 2004
    ..Our results suggest that baseline intake of alcohol is a more important determinant of postmenopausal breast cancer risk than earlier lifetime exposure...
  28. ncbi Breast tumours following combined hormone replacement therapy express favourable prognostic factors
    Signe Borgquist
    Department of Laboratory Medicine, Division of Pathology, Malmo University Hospital, Lund University, SE 20502 Malmo, Sweden
    Int J Cancer 120:2202-7. 2007
    ..We conclude that the use of CHRT is associated with an increased incidence of breast tumours with comparatively favourable prognostic factors...
  29. ncbi Effects of estrogen replacement therapy on natriuretic peptides and blood pressure
    Anna H Karjalainen
    Department of Internal Medicine, Biocenter Oulu, University of Oulu, P O Box 20, 90029 OYS, Oulu, Finland
    Maturitas 47:201-8. 2004
    b>Estrogen replacement therapy (ERT) has been reported to affect blood pressure...
  30. pmc Ovarian cancer risk factors by histologic subtypes in the NIH-AARP Diet and Health Study
    Hannah P Yang
    Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 131:938-48. 2012
    ..83 (serous). Obesity was a significant risk factor only for endometrioid cancers (RR = 1.64; 95% CI: 1.00, 2.70). Our findings support a link between etiological factors and histological heterogeneity in ovarian carcinoma...
  31. ncbi Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study
    Marianne Canonico
    INSERM Unit 780, Cardiovascular Epidemiology Section, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Circulation 115:840-5. 2007
    ..Transdermal estrogen may be safer. However, currently available data have limited the ability to investigate the wide variety of types of progestogen...
  32. ncbi Risk factors for cataract subtypes waterclefts and retrodots: two case-control studies
    J S Durant
    Bristol Eye Hospital, Bristol, UK
    Eye (Lond) 20:1254-67. 2006
    ..Waterclefts and retrodots are independently associated with visual impairment, yet a review identified no data on risk factors...
  33. ncbi Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)
    Deborah Grady
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 74 New Montgomery St, Suite 600, San Francisco, CA 94105, USA
    JAMA 288:49-57. 2002
    ..However, in the hormone group, findings did suggest a higher risk of CHD events during the first year, and a decreased risk during years 3 to 5...
  34. ncbi Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium
    Lei Deng
    Department of Integrative Biology and Pharmacology, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 88:2157-63. 2003
    ..that retinaldehyde dehydrogenase (RALDH) 2, a critical enzyme in RA biosynthesis, was induced 4-fold by estrogen replacement therapy with either Premarin or a mixture of estrone and equilin sulfates for 3 months...
  35. ncbi Estrogen replacement therapy decreases platelet-activating factor-acetylhydrolase activity in post-menopausal women
    T Yoshimura
    Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Japan
    Maturitas 31:249-53. 1999
    To examine the effects of estrogen replacement therapy on plasma platelet-activating factor-acetylhydrolase (PAF-AH) activity and the lipoprotein profile in post-menopausal women.
  36. ncbi Estrogen replacement in menopausal women: recent and current prospective studies, the WHI and the KEEPS
    S Mitchell Harman
    Kronos Longevity Research Institute, 2390 E Camelback, Phoenix, AZ 85016, USA
    Gend Med 3:254-69. 2006
    ..The risks of adverse health effects must be balanced against the benefits associated with HRT Further research into the timing of estrogen replacement treatment may be crucial to the prevention of cardiovascular disease...
  37. ncbi Interactions between body mass index and hormone therapy and postmenopausal breast cancer risk (United States)
    Christopher I Li
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, 1100 Fairview Avenue North, M4 C308, 19024, Seattle, Washington 98109 1024, USA
    Cancer Causes Control 17:695-703. 2006
    ..To assess interactions between use of estrogen plus progestin hormone therapy (EPHT) and body mass index (BMI) in relation to risks of different types of breast cancer, based on histology and hormone receptor status...
  38. ncbi Risks of estrogen plus progestin therapy: a sensitivity analysis of findings in the Women's Health Initiative randomized controlled trial
    S Shapiro
    Department of Epidemiology, Mailman School of Public Health, Columbia University, USA
    Climacteric 6:302-10; discussion 310-3. 2003
    ..The possibility that the findings could have been accounted for by bias was not considered...
  39. ncbi A large multinational study of vasomotor symptom prevalence, duration, and impact on quality of life in middle-aged women
    Juan E Blumel
    Collaborative Group for Research of the Climacteric in Latin America
    Menopause 18:778-85. 2011
    ..The aim of this study was to determine vasomotor symptom (VMS) prevalence, duration, and impact on quality of life in middle-aged women using a validated menopausal tool...
  40. pmc Lung cancer among postmenopausal women treated with estrogen alone in the women's health initiative randomized trial
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Natl Cancer Inst 102:1413-21. 2010
    ..We conducted post hoc analyses in the WHI trial evaluating estrogen alone to determine whether use of conjugated equine estrogen without progestin had a similar adverse influence on lung cancer...
  41. pmc Estrogen replacement restores flow-induced vasodilation in coronary arterioles of aged and ovariectomized rats
    Amanda J LeBlanc
    Center for Cardiovascular and Respiratory Sciences, West Virginia University, Morgantown, West Virginia, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1713-23. 2009
    ....
  42. ncbi Longitudinal effects of estrogen replacement therapy on PET cerebral blood flow and cognition
    P M Maki
    Laboratory of Personality and Cognition, Gerontology Research Center, NIA NIH, Box 3, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 21:373-83. 2000
    Observational studies suggest that estrogen replacement therapy (ERT) may protect against age-related memory decline and lower the risk of Alzheimer's disease (AD)...
  43. ncbi Duration of vasomotor symptoms in middle-aged women: a longitudinal study
    Nananda F Col
    Center for Outcomes Research and Evaluation, Maine Medical Center, Portland, ME 04101, USA
    Menopause 16:453-7. 2009
    ..The most effective treatment, hormone therapy (HT), carries risks and benefits that depend on the timing and duration of use. In this study we sought to estimate the duration of vasomotor symptoms in a longitudinal study...
  44. pmc How the Women's Health Initiative (WHI) influenced physicians' practice and attitudes
    Terry M Bush
    Group Health Center for Health Studies, Seattle, WA 98101, USA
    J Gen Intern Med 22:1311-6. 2007
    ....
  45. pmc Correlates and consequences of venous thromboembolism: The Iowa Women's Health Study
    Pamela L Lutsey
    University of Minnesota, Minneapolis, USA
    Am J Public Health 100:1506-13. 2010
    ..We sought to document incidence, case-fatality, and recurrence rates of venous thromboembolism (VTE) in women and to explore the relationship of demographic, lifestyle, and anthropometric factors to VTE incidence...
  46. ncbi Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study
    Sally A Shumaker
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    JAMA 291:2947-58. 2004
    ..The Women's Health Initiative Memory Study (WHIMS) previously found increased risk for dementia and no effect on mild cognitive impairment (MCI) in women treated with conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA)...
  47. pmc Protective effects of estrogen in a rat model of age-related cataracts
    R M Bigsby
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46228, USA
    Proc Natl Acad Sci U S A 96:9328-32. 1999
    ..Thus, the MNU-treated, ovariectomized rat serves as a model for age-related cataractogenesis, and observation of a clear protective effect of estrogens in this system supports the implications of epidemiologic data...
  48. ncbi Estrogen replacement therapy and risk of lung cancer
    Janine A Blackman
    Department of Family Practice, Franklin Square Hospital Center, Baltimore, MD, USA
    Pharmacoepidemiol Drug Saf 11:561-7. 2002
    ..We assessed the relation of the use of estrogen replacement therapy (ERT) to the risk of lung cancer in our hospital-based Case-Control Surveillance Study, conducted in ..
  49. pmc Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease
    Miguel A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Epidemiology 19:766-79. 2008
    ..Observational studies had previously suggested reduced CHD risk in hormone users...
  50. ncbi Relationship between long durations and different regimens of hormone therapy and risk of breast cancer
    Christopher I Li
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    JAMA 289:3254-63. 2003
    ..Women using combined estrogen and progestin hormone replacement therapy (CHRT) have an increased risk of breast cancer; however, data on use for long durations and on risk associated with patterns of use are lacking...
  51. ncbi Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial
    Stephen R Rapp
    Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    JAMA 289:2663-72. 2003
    ..On July 8, 2002, the estrogen plus progestin therapy in the WHI trial was discontinued because of certain increased health risks for women...
  52. ncbi Effect of postmenopausal hormone therapy on glucose and insulin concentrations. PEPI Investigators. Postmenopausal Estrogen/Progestin Interventions
    M A Espeland
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes Care 21:1589-95. 1998
    ..To characterize the long-term impact of four hormone therapy regimens on insulin and glucose concentrations measured during a standard oral glucose tolerance test...
  53. ncbi Prognostic characteristics of breast cancer among postmenopausal hormone users in a screened population
    Karla Kerlikowske
    San Francisco Veterans Affairs Medical Center, General Internal Medicine Section, 111A1, 4150 Clement St, San Francisco, CA 94121, USA
    J Clin Oncol 21:4314-21. 2003
    ..We determined the risk of breast cancer and tumor characteristics among current postmenopausal hormone therapy users compared with nonusers, by duration of use...
  54. ncbi Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women
    S Vehkavaara
    Department of Medicine, University of Helsinki, Finland
    Thromb Haemost 85:619-25. 2001
    ....
  55. pmc Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause
    Ross L Prentice
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Am J Epidemiol 170:12-23. 2009
    ....
  56. ncbi Intimal estrogen receptor (ER)beta, but not ERalpha expression, is correlated with coronary calcification and atherosclerosis in pre- and postmenopausal women
    Rose C Christian
    Amgen, Inc, One Amgen Center Drive, Thousand Oaks, California 91361, USA
    J Clin Endocrinol Metab 91:2713-20. 2006
    ..In this study, we examined coronary artery ERalpha and ERbeta expression in pre- and postmenopausal women as a function of plaque area, calcium area, calcium-to-plaque ratio, and estrogen status...
  57. ncbi Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial
    H N Hodis
    Atherosclerosis Research Unit, University of Southern California, 2250 Alcazar Street, CSC 132, Los Angeles, CA 90033, USA
    Ann Intern Med 135:939-53. 2001
    Although observational studies suggest that estrogen replacement therapy (ERT) reduces cardiovascular morbidity and mortality in postmenopausal women, use of unopposed ERT for prevention of coronary heart disease in healthy postmenopausal ..
  58. ncbi Transdermal estrogen replacement therapy decreases sympathetic activity in postmenopausal women
    W Vongpatanasin
    Division of Hypertension, Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Circulation 103:2903-8. 2001
    ..SND, however, has not been recorded during estrogen replacement therapy (ERT) in humans...
  59. ncbi Estrogen regulation of angiotensin-converting enzyme mRNA
    P E Gallagher
    Hypertension and Vascular Disease Center, Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 33:323-8. 1999
    b>Estrogen replacement therapy is cardioprotective in postmenopausal women; however, the precise molecular mechanisms for this modulation are not fully elucidated...
  60. ncbi Hormone therapy and ovarian cancer
    Lina Steinrud Mørch
    Gynaecological Clinic, Rigshospitalet, Copenhagen University, 2100 Copenhagen, Denmark
    JAMA 302:298-305. 2009
    ..Studies have suggested an increased risk of ovarian cancer among women taking postmenopausal hormone therapy. Data are sparse on the differential effects of formulations, regimens, and routes of administration...
  61. ncbi Hormone replacement therapy and lens opacities: the Salisbury Eye Evaluation project
    E E Freeman
    Wilmer Eye Institute, Room 129, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21210, USA
    Arch Ophthalmol 119:1687-92. 2001
    ..CONCLUSION: A protective association between the use of HRT and nuclear and posterior subcapsular opacities is reported, which should be confirmed in prospective studies...
  62. pmc Effect of hormone therapy on lean body mass, falls, and fractures: 6-year results from the Women's Health Initiative hormone trials
    Jennifer W Bea
    Arizona Cancer Center, Tucson, AZ 85724 5024, USA
    Menopause 18:44-52. 2011
    ....
  63. ncbi Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    S Hulley
    University of California, San Francisco 94143, USA
    JAMA 280:605-13. 1998
    ..However, given the favorable pattern of CHD events after several years of therapy, it could be appropriate for women already receiving this treatment to continue...
  64. ncbi Different cardiovascular effects of progestins according to structure and activity
    A Nath
    Tietze fellow from the Population Council, New York, NY, USA
    Climacteric 12:96-101. 2009
    ..Although it is likely that the new progestins may be neutral on the coronary disease risk, when administered to the younger postmenopausal woman, this has not as yet been documented by large, randomized, controlled trials...
  65. ncbi Type of menopause, patterns of hormone therapy use, and hot flashes
    Lisa Gallicchio
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Fertil Steril 85:1432-40. 2006
    ....
  66. ncbi Exogenous oestrogen exposure, female reproductive factors and the long-term incidence of cataract: the Blue Mountains Eye Study
    Gowri L Kanthan
    Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Australia
    Acta Ophthalmol 88:773-8. 2010
    ..To assess the association between exogenous oestrogen exposure, female reproductive factors and the long-term incidence of cataract...
  67. ncbi Hormone replacement therapy in relation to risk of cataract extraction: a prospective study of women
    Birgitta Ejdervik Lindblad
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Ophthalmology 117:424-30. 2010
    ..To investigate the association between hormone replacement therapy (HRT) and the incidence of cataract extraction among postmenopausal women...
  68. ncbi Selective estrogen receptor modulators (SERMs) for the brain: current status and remaining challenges for developing NeuroSERMs
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, School of Pharmacy, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Brain Res Brain Res Rev 49:472-93. 2005
    ..Results of these endeavors have yielded insights into strategies for developing novel molecules with NeuroSERM potential in order to prevent brain related climacteric symptoms and neurodegenerative diseases...
  69. ncbi A longitudinal study of the treatment of hot flushes: the population study of women in Gothenburg during a quarter of a century
    Kerstin Rödström
    Department of Primary Health Care, Sahlgrenska akademin, Sahlgrenska University Hospital, Goteborg University, Sweden
    Menopause 9:156-61. 2002
    ..To describe the prevalence and treatment of hot flushes in premenopausal and postmenopausal women from the 1960s to the 1990s...
  70. ncbi Pilot study on the effect of estrogen replacement therapy on brain dopamine transporter availability in healthy, postmenopausal women
    Sara A Gardiner
    ePharmaLearning, Inc
    Am J Geriatr Psychiatry 12:621-30. 2004
    Authors investigated the association between estrogen replacement therapy (ERT) and dopamine transporter (DAT) availability in women.
  71. pmc Menopausal hormone therapy and subsequent risk of specific invasive breast cancer subtypes in the California Teachers Study
    Tanmai Saxena
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:2366-78. 2010
    ....
  72. pmc Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial
    Andrea Z LaCroix
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, PO 19024, Seattle, WA 98109
    JAMA 305:1305-14. 2011
    ..1 years of follow-up because of an increased risk of stroke and little likelihood of altering the balance of risk to benefit by the planned trial termination date. Postintervention health outcomes have not been reported...
  73. ncbi Hormone replacement therapy and breast cancer
    Anthony Howell
    Genesis Prevention Centre, University Hospital of South Manchester, Manchester, UK
    Recent Results Cancer Res 188:115-24. 2011
    ..HRT may thus reduce the risk of breast cancer and other diseases (e.g., cardiovascular) in young women and increase or decrease them in older women...
  74. pmc Attitudes of obstetrician-gynecologists toward the evidence from the Women's Health Initiative hormone therapy trials remain generally skeptical
    Michael L Power
    Research Department, American College of Obstetricians and Gynecologists, Washington, DC 20024, USA
    Menopause 16:500-8. 2009
    ..To examine the opinions of obstetrician-gynecologists regarding hormone therapy (HT) and the results from the Women's Health Initiative (WHI)...
  75. ncbi Estrogen replacement therapy and breast cancer survival in a large screening study
    C Schairer
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7374, USA
    J Natl Cancer Inst 91:264-70. 1999
    ..We examined breast cancer mortality among women who were diagnosed with axillary lymph node-negative and node-positive breast cancer according to the currency of estrogen use at diagnosis...
  76. pmc Impact of combined estradiol and norethindrone therapy on visuospatial working memory assessed by functional magnetic resonance imaging
    Yolanda R Smith
    Department of Obstetrics and Gynecology, School of Public Health, University of Michigan Health Systems, Women s Hospital, Ann Arbor, Michigan 48109 0276, USA
    J Clin Endocrinol Metab 91:4476-81. 2006
    ..Hormones regulate neuronal function in brain regions critical to cognition; however, the cognitive effects of postmenopausal hormone therapy are controversial...
  77. ncbi Hormone therapy and different ovarian cancers: a national cohort study
    Lina Steinrud Mørch
    Gynecological Clinic, Copenhagen University Hospital, University of Copenhagen, Denmark
    Am J Epidemiol 175:1234-42. 2012
    ..Consistent with results from recent cohort studies, the authors found that ovarian cancer risk varied according to tumor histology. The types of ovarian tumors should be given attention in future studies...
  78. ncbi Estrogen replacement therapy: effects on the cognitive functioning and clinical course of women with Alzheimer's disease
    Andrew J Levine
    Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, Room C8 747 NPI, Los Angeles, CA 90024 1759, USA
    Arch Clin Neuropsychol 19:769-78. 2004
    This study examined the effects of unopposed estrogen replacement therapy (ERT) on the cognition and clinical course of women who have been diagnosed with probable Alzheimer's disease...
  79. ncbi Prospective assessment of estrogen replacement therapy and cognitive functioning: atherosclerosis risk in communities study
    S A de Moraes
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 154:733-9. 2001
    Studies of humans have not confirmed the suggestion from animal studies that estrogen replacement therapy may have an inverse relation with cognitive function decline...
  80. ncbi Effects of estrogen replacement therapy on vascular endothelial growth factor expression in choroidal and retinal vasculature
    S O Dundar
    Department of Ophthalmology, Adnan Menderes University School ofMedicine, Aydin, Turkey
    Bratisl Lek Listy 111:473-6. 2010
    To investigate the effects of estrogen replacement therapy (ERT) on vascular endothelial growth factor (VEGF) expression in choroidal and retinal vasculature in experimental rat model.
  81. pmc Dramatic change in prescribing of hormone replacement therapy in The Netherlands after publication of the Million Women Study: a follow-up study
    Adrianne Faber
    Groningen University Institute for Drug Exploration, University of Groningen, Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen, The Netherlands
    Br J Clin Pharmacol 60:641-7. 2005
    ..To estimate the diffusion of new safety information concerning postmenopausal hormonal replacement therapy (HRT) into prescribing practice in The Netherlands and to assess the impact of revised guidelines on the long-term treatment of HRT...
  82. ncbi Oestrogen replacement therapy may improve memory functioning in the absence of APOE epsilon4
    M S Burkhardt
    Sir James McCusker Alzheimer s Disease Research Unit, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Hollywood Private Hospital, Perth, Western Australia, Australia
    J Alzheimers Dis 6:221-8. 2004
    ..005) tests of memory. The findings have significance for evaluating whether and when ERT may be clinically indicated. Specifically, ERT may benefit the cognitive functioning of women not carrying the APOE epsilon4 allele...
  83. ncbi Breast cancer and hormone-replacement therapy in the Million Women Study
    Valerie Beral
    Cancer Research UK Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
    Lancet 362:419-27. 2003
    ..Current use of hormone-replacement therapy (HRT) increases the incidence of breast cancer. The Million Women Study was set up to investigate the effects of specific types of HRT on incident and fatal breast cancer...
  84. ncbi Estrogen replacement therapy is associated with less progression of subclinical structural brain disease in normal elderly women: a pilot study
    Ian A Cook
    UCLA Neuropsychiatric Institute and the Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine Los Angeles, CA 90024 1759, USA
    Int J Geriatr Psychiatry 17:610-8. 2002
    ..Cortical atrophy, central atrophy, deep white-matter hyperintensities, and periventricular hyperintensities are reported in normal aging...
  85. ncbi Breast cancer and hormone-replacement therapy: the Million Women Study
    Sarah Gray
    Lancet 362:1332; author reply 1332. 2003
  86. ncbi DHEA therapy for women: effect on sexual function and wellbeing
    M Panjari
    NH and MRC Centre of Clinical Research Excellence in the Women s Health Program, Department of Medicine, Central and Eastern Clinical School, Monash University, Alfred Hospital, Prahran, Victoria, Australia
    Hum Reprod Update 13:239-48. 2007
    ..The studies of DHEA therapy in women with adrenal insufficiency suggest that this group is the most likely to derive health benefits from DHEA supplementation...
  87. ncbi Estrogen replacement therapy: effects on the endogenous androgen milieu
    James A Simon
    George Washington University School of Medicine, Washington, D C, USA
    Fertil Steril 77:S77-82. 2002
    To review the impact of exogenous estrogen replacement therapy (ERT) on the production, binding, and metabolism of ovarian and adrenal androgens.
  88. ncbi Menopausal hormone therapy and breast cancer risk: impact of different treatments. The European Prospective Investigation into Cancer and Nutrition
    Kjersti Bakken
    Department of Community Medicine, University of Tromsø, Tromsø, Norway
    Int J Cancer 128:144-56. 2011
    ..Continuous combined preparations were associated with the highest risk. Further studies are needed to disentangle the effects of the regimen and the progestin component...
  89. ncbi Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial
    Rowan T Chlebowski
    Harbor UCLA Research and Education Institute, Torrance 90502, USA
    JAMA 289:3243-53. 2003
    ..Outstanding issues not previously addressed include characteristics of breast cancers observed among women using hormones and whether diagnosis may be influenced by hormone effects on mammography...
  90. ncbi Effects of current and discontinued estrogen replacement therapy on hip structural geometry: the study of osteoporotic fractures
    T J Beck
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Bone Miner Res 16:2103-10. 2001
    ..Scans were studied with a hip structural analysis program for the effects of estrogen replacement therapy (ERT) on BMD and structural geometry...
  91. ncbi The estrogen replacement therapy of the Women's Health Initiative promotes the cellular mechanisms of memory and neuronal survival in neurons vulnerable to Alzheimer's disease
    R D Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Maturitas 34:S35-52. 2000
    ..action of the complex formulation of conjugated equine estrogens (CEEs), the most frequently prescribed estrogen replacement therapy in the United States and the estrogen replacement therapy of the Women's Health Initiative.
  92. ncbi Perimenopause: more than hot flushes and night sweats for some Australian women
    Carol McVeigh
    Massey University, Wellington Campus, Private Box 756, Wellington New Zealand
    J Obstet Gynecol Neonatal Nurs 34:21-7. 2005
    ..To identify the most common perimenopausal symptoms experienced by a group of Australian women and explore the extent to which those symptoms were distressing...
  93. ncbi Hormone replacement therapy and acute coronary outcomes: methodological issues between randomized and observational studies
    E Garbe
    Institute of Clinical Pharmacology, Charite, Humboldt University, Berlin, Germany
    Hum Reprod 19:8-13. 2004
    ..82. The diametrical effects of HRT on acute coronary outcomes found between the observational studies and the WHI Study may be a result not only of bias in the observational studies, but also of bias in the WHI Study...
  94. ncbi Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause
    Jacques E Rossouw
    Women s Health Initiative Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    JAMA 297:1465-77. 2007
    ..The timing of initiation of hormone therapy may influence its effect on cardiovascular disease...
  95. ncbi Impact of estrogen therapy on Alzheimer's disease: a fork in the road?
    Roberta D Brinton
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, California, USA
    CNS Drugs 18:405-22. 2004
    ..An estrogen advantage hypothesis is put forth that provides a unifying mechanism of estrogen action with implications for both the benefits and risks of estrogen therapy...
  96. ncbi Experience of climacteric symptoms among 42-46 and 52-56-year-old women
    K Jokinen
    Loimaa Public Health Authority, Loimaa, Finland
    Maturitas 46:199-205. 2003
    ..The intensity of climacteric symptoms and their connection with sociodemographic background data were assessed among women who are or will soon be menopausal...
  97. ncbi Estrogen replacement therapy and frontotemporal dementia
    Andrew J Levine
    Neuropsychiatric Institute, University of California Los Angeles, 760 Westwood Plaza, Room C8 747, Los Angeles, CA 90024 1759, USA
    Maturitas 45:83-8. 2003
    To examine the relationship between estrogen replacement therapy (ERT) and frontotemporal dementia (FTD).
  98. ncbi Progestogens: effects on clinical and biochemical parameters in postmenopausal women
    David F Archer
    Menopause 12:484-7. 2005
  99. ncbi Nonvertebral "osteoporotic" fractures: a brain disease or bone disease?
    Stanley J Birge
    Menopause 14:1-2. 2007
  100. pmc Positive association of the hepatic lipase gene polymorphism c.514C > T with estrogen replacement therapy response
    Alvaro Pulchinelli
    Laboratorio de Biologia Molecular, Departamento de Ginecologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Lipids Health Dis 10:197. 2011
    ..DNA was extracted from the buccal and blood cells of all 58 patients using a commercially available kit (GFX® - Amersham-Pharmacia, USA)...

Research Grants64

  1. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..This will allow me to make significant contributions to our knowledge of the neural and neurochemical mechanisms that lead to hot flashes and to identify potential novel nonhormonal targets for treatment. ..
  2. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..b>Estrogen replacement therapy has been found to decrease body fat mass as well as intra-abdominal and intrapelvic fat in ..
  3. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..greater in aged women when compared to aged men, and data from large scale clinical trials suggest that estrogen replacement therapy is ineffective in reducing, and may actually increase CVD outcomes...
  4. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..project builds on a recent double-blind, placebo- controlled trial of dehydroepiandrosterone (DHEA) and estrogen replacement therapy (ERT) in adolescents with AN...
  5. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..This project may allow disclose novel targets for development of more effective anti-resorptive therapies for osteoporosis and related disease. Thus, this project is highly relevant to the VA patient care mission. ..
  6. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..The proposal addresses this unmet need by investigating a potentially liability-free estrogen replacement therapy, i.e., the use of para-quinol of estrogen as a prodrug approach...
  7. Estrogen, Aging and Vascular Inflammation
    Anne A Knowlton; Fiscal Year: 2013
    ..Although the work focuses on estrogen and EETs, it will provide new insights and potentially new therapies (sEH inhibitors) vascular disease, which can help both male and female veterans. ..
  8. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    ..These studies will provide information on the interaction of estrogen and BDNF in affective disorders and could lead to improved hormone replacement therapies to alleviate menopausal symptoms. ..
  9. Estrogen-T cell Interactions
    Prakash S Nagarkatti; Fiscal Year: 2013
    ..Postmenopausal women are treated with estrogen replacement therapy to relieve them of the menopausal symptoms...
  10. Depression, Estrogen Replacement, and Cardiovascular Health in the Perimenopause
    David R Rubinow; Fiscal Year: 2013
    ..abstract_text> ..
  11. Gender Specific Complications of Diabetic Autonomic Neuropathy: A New Mouse Model
    JONAS BERNARD GALPER; Fiscal Year: 2010
    ....
  12. MOLECULAR AND CELLULAR MECHANISMS OF OSTEOPOROSIS
    Stavros C Manolagas; Fiscal Year: 2013
    ....
  13. SERT KO rats are a model of sex specific visceral pain
    James J Galligan; Fiscal Year: 2013
    ..The data would indicate that the SERT KO rat is a model for studying changes in the sensory nerve supply of the gut that leads to visceral hypersensitivity. ..
  14. ERalpha and the metabolic syndrome
    Andrea L Hevener; Fiscal Year: 2013
    ....
  15. Genetic and estrogen-dependent regulation of the human PAC1R receptor and PTSD
    Kerry J Ressler; Fiscal Year: 2013
    ..We will further examine the mechanisms of PAC1 regulation using human lymphoblast cell lines of differing PAC1 rs2267735 genotypes. ..
  16. Sex, sex steroids and dry eye syndromes
    David A Sullivan; Fiscal Year: 2013
    ..caused by meibomian gland dysfunction and may be a major cause of dry eye during menopause, use of estrogen replacement therapy and aging...
  17. Estrogen Receptor and Cardiovascular Function
    Ellis R Levin; Fiscal Year: 2013
    ..These data may justify in the future initial translational trials in post-menopausal women, including veterans. ..
  18. Adolescence, Impulsivity, and Drug Abuse: Sex/Hormones
    Marilyn E Carroll; Fiscal Year: 2012
    ..The study of impulsivity in drug-seeking behavior will increase our understanding of the etiology, prevention, and treatment of drug abuse. ..
  19. Effects of Age on Ethanol Withdrawal Toxicity: Mechanisms and Therapy
    Marianna E Jung; Fiscal Year: 2010
    ..These studies may ultimately contribute to a better understanding of and strategy for female alcoholics undergoing EW during brain aging. ..
  20. BDNF AND HIPPOCAMPAL HYPEREXCITABILITY
    Helen E Scharfman; Fiscal Year: 2010
    ..Moreover, our data will provide support for new anticonvulsant strategies for women with epilepsy based on inhibiting BDNF or enhancing VEGF. ..
  21. Interplay Between Estrogen, GPR30 and Chymase/RAS in Diastolic Function
    Leanne Groban; Fiscal Year: 2013
    ..after menopause, there is a significant need for therapies that confer the cardiovascular benefits of estrogen replacement therapy without its adverse effects...
  22. Ligand-independent signaling of estrogen receptor beta and the aging brain
    Toni R Pak; Fiscal Year: 2013
    ..WHI) conducted a large-scale clinical study designed to evaluate the neurological benefits of estrogen replacement therapy for post-menopausal women...
  23. Relaxin: A Novel HRT for Prevention of Cardiac Disease
    ROLANDO JUAN JOSE RAMIREZ; Fiscal Year: 2011
    ..b>Estrogen replacement therapy is effective in relieving the symptoms of menopause but recent clinical trials have failed to ..
  24. Identification of novel phytoprogestins from hops and red clover
    Joanna E Burdette; Fiscal Year: 2011
    ..Unopposed estrogen replacement therapy increases the risk of developing endometrial cancer by 120% for every 5 years of use...
  25. Hot Flushes and SNPs of the Norepinephrine and Serotonin Transporter Genes
    ISTVAN JOZSEF MERCHENTHALER; Fiscal Year: 2012
    ..Although the most efficacious therapy for hot flushes is estrogen replacement therapy, due to the potential risks involved with hormone therapy, many women try to find alternative therapies,..
  26. Regulation of Human Bone Turnover by FSH
    Harry C Blair; Fiscal Year: 2012
    ..We discovered that the pituitary hormone FSH, which regulates estrogen production, may cause bone loss directly. We will study this FSH response in bone to provide new insights into prevention of osteoporosis. ..
  27. BOTANICAL CENTER FOR AGE-RELATED DISEASES
    Connie M Weaver; Fiscal Year: 2010
    Several types of botanical products containing isoflavones are being marketed as an alternative to estrogen replacement therapy to prevent osteoporosis in postmenopausal women...
  28. Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling and Inflammation
    Tomoki Hashimoto; Fiscal Year: 2013
    ..Furthermore, estrogen replacement therapy reduces the risk for aneurysmal subarachnoid hemorrhage in post-menopausal women...
  29. Dopaminergic and glutamatergic mechanisms of cocaine addiction: sex differences
    WENDY JEAN LYNCH; Fiscal Year: 2012
    ..These studies will provide a much needed foundation for the development of hormonal, pharmacological, and/or molecular based therapeutics for cocaine abuse, especially in women. ..
  30. Steroid-catecholamine-brain interactions in auditory-driven social behavior
    Paul M Forlano; Fiscal Year: 2013
    ....
  31. Impact of Endocrine Aging on Brain and Immune Responses
    Farida Sohrabji; Fiscal Year: 2010
    ..Collectively, these studies will test the hypothesis that in order for estrogen replacement to be beneficial, therapy must be initiated before compensatory responses to ovarian decline. ..
  32. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..abstract_text> ..
  33. Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
    Madhusmita Misra; Fiscal Year: 2013
    ..abstract_text> ..
  34. Research Training in Natural Product Complementary and Alternative Medicine
    Richard B van Breemen; Fiscal Year: 2013
    ..on evaluating the safety and efficacy of botanical dietary supplements used by women as alternatives to estrogen replacement therapy at menopause...
  35. ESTROGENS AND VITAMIN A ROLE IN DISEASE PREVENTION
    Annlia Paganini Hill; Fiscal Year: 1991
    ..of several chronic diseases to meet the specific aims of: (1) Evaluating the risks and benefits of estrogen replacement therapy in terms of incident disease and mortality (including endometrial cancer, breast cancer, osteoporotic ..
  36. ESTROGEN REGULATION OF HUMAN INTERLEUKIN 6 GENE PROMOTER
    Sreenivas Koka; Fiscal Year: 1999
    ..Decreased estrogen production by post-menopausal women is associated with loss of bone mass and estrogen replacement therapy is a primary treatment modality to preserve bone mass...
  37. Biotransformation of Estrogens to Carcinogenic Quinoids
    JUDY BOLTON; Fiscal Year: 2005
    ..cancers are all associated with longer estrogen exposure; early menses, late menopause, and long term estrogen replacement therapy. The mechanism(s) of estrogen carcinogenesis is not known...
  38. BIOTRANSFORMATION OF ESTROGEN TO CARCINOGENIC QUINOIDS
    JUDY BOLTON; Fiscal Year: 2000
    ..cancers are all associated with longer estrogen exposure; early menses, late menopause, and long term estrogen replacement therapy. The mechanism(s) of estrogen carcinogenesis is unknown...
  39. A Molecular Basis for Phytoestrogen Chemoprevention
    Andrew Mesecar; Fiscal Year: 2002
    Despite the proven health benefits of estrogen replacement therapy (ERT) in their postmenopausal years, only 30% of women in the United States are currently receiving ERT because of a clear association between excessive exposure to ..
  40. ECDYSTEROID REGULATION OF INVERTEBRATE CALCITONIN
    LAURENS SMITH; Fiscal Year: 1993
    ..severe estrogen deficiency, often suffer enhanced osteoporotic bone loss, which may be arrested with estrogen replacement therapy and although controversial, many studies have measured a postmenopausal decrease of plasma ..
  41. FEMORAL OSTEOPOROSIS IN ELDERLY WOMEN
    Susan Greenspan; Fiscal Year: 1999
    ..that in women age 65 and over: (1) a) bisphosphonate therapy will maintain femoral bone mass, b) estrogen replacement therapy will independently aid in maintaining hip bone mineral density, and c) the combination of ..
  42. Estrogen and brain vascular inflammation in diabetics
    Dale Pelligrino; Fiscal Year: 2007
    ..The present project is based upon the concept that clinically-relevant circumstances may occur where estrogen replacement therapy (ERT) is no longer neuroprotective, but neurotoxic...
  43. Hypnosis for Hot Flashes in Breast Cancer Survivors
    Gary Elkins; Fiscal Year: 2005
    ..of ovarian failure and hot flashes occurring either premenopausally or postmenopausally has been estrogen replacement therapy for women with no history of breast cancer...
  44. CVD Mechanisms Associated with Phytoestrogens Use
    Donna Kritz Silverstein; Fiscal Year: 2003
    b>Estrogen replacement therapy has beneficial effects on heart disease risk factors. However, a large proportion of postmenopausal women are not compliant with therapeutic regimens...
  45. SOYBEANS AND CALCIUM METABOLISM IN POSTMENOPAUSAL WOMEN
    ELAINE LIPSCOMB; Fiscal Year: 1999
    ..b>Estrogen replacement therapy (ERT) is one of the mainstays for the prevention and treatment of osteoporosis in postmenopausal women...
  46. Chemoprevention of Uterine Cancer Risk by Antioxidants
    Minoti Sharma; Fiscal Year: 2003
    ..Long-term estrogen replacement therapy for postmenopausal syndrome also increases endometrial cancer risk...
  47. IN VITRO MODEL OF HUMAN VAGINAL EPITHELIUM
    Ann Stapleton; Fiscal Year: 2000
    ..A healthy vaginal ecosystem is critical to reproductive health. Estrogen replacement therapy and many contraceptive products and devices are vaginally delivered and may affect the vaginal ..
  48. ESTROGEN MODULATION OF BRAIN ABETA METABOLISM IN VIVO
    Samuel Gandy; Fiscal Year: 2004
    ..Epidemiological studie indicate that estrogen replacement therapy (ERT) in postmenopausal women appears to decrease the risk of AD or to delay its onset, but the ..
  49. FLAXSEED PHYTOESTROGENS MAY POSITIVELY AFFECT BONE
    Bahram Arjmandi; Fiscal Year: 1999
    ..that flaxseed will have beneficial effects on bone mass in postmenopausal women who have not been on estrogen replacement therapy (HRT) for at least one year prior to the start of the study...
  50. MELATONIN FOR SLEEP DISTURBANCES DURING MENOPAUSE
    Andrea Suhner; Fiscal Year: 2001
    ..b>Estrogen replacement therapy can alleviate these symptoms, yet side effects and contraindications make the use of this hormone ..
  51. Hormone Replacement and Cerebral Glucose Metabolism
    John Woodard; Fiscal Year: 2000
    Epidemiological studies have suggested that estrogen replacement therapy (ERT) may reduce the risk of developing Alzheimer?s disease and may slow cognitive decline in demented women...
  52. COGNITIVE AGING: EFFECTS OF ESTRADIOL AND RALOXIFENE
    AGNES LACREUSE; Fiscal Year: 2000
    ..b>Estrogen Replacement Therapy (ERT) is often prescribed to menopausal women to protect against such adverse consequences of estrogen ..
  53. ANDROGEN EFFECTS ON COGNITION IN TURNER SYNDROME
    Judith Ross; Fiscal Year: 2007
    ..Additionally, all TS girls (both treatment groups) receive standard estrogen replacement therapy during the 3rd and 4th years of the study...
  54. Role of Ovarian Senescence in End Stage Renal Disease
    Hong Ji; Fiscal Year: 2001
    ..cardiovascular disease, bone loss and cognitive function is also much less in post-menopausal women on estrogen replacement therapy (ERT) compared to those without ERT...
  55. Estrogen, Vitamin E, and Cognitive Change in Women
    Julie Dunn; Fiscal Year: 2005
    ..2. Effects of estrogen replacement therapy (ERT) on CF measures over 3 years in women age 60 and over...
  56. Alternative Estrogen Replacement Therapy for Colon Canc*
    Martha Campbell Thompson; Fiscal Year: 2004
    Botanical products are becoming increasingly popular as alternatives to estrogen replacement therapy (ERT). Clinical evidence strongly supports an association between ERT and reduced risk of colon cancer in postmenopausal women...
  57. PROGESTOGENS VS PHYTOESTROGENS-- AN ADJUNCT TO ERT
    James Williams; Fiscal Year: 2004
    DESCRIPTION: (Adapted from the applicant's abstract) There is now a consensus that postmenopausal estrogen replacement therapy (ERT) reduces morbidity and mortality from coronary heart disease (CHD)...
  58. Role of PI3-Kinase in Estrogen-induced eNOS Activation
    James Liao; Fiscal Year: 2007
    ..decreased risk has been attributed to the beneficial effects of estrogen in premenopausal women and estrogen replacement therapy in post-menopausal woman...
  59. ESTROGEN TREATMENT OF MOOD DISTURBANCES IN THE MENOPAUSE
    EDWARD KLAIBER; Fiscal Year: 1992
    ..b>Estrogen replacement therapy (ERT) has been reported to have a beneficial effect on some of these mood and behavior changes...
  60. Estrogens and Insulin Resistance in Women
    Jerrold Olefsky; Fiscal Year: 2006
    ..showing that post-menopausal women are fully susceptible to fat-induced insulin resistance and that estrogen replacement therapy re-establishes the protective state...
  61. ESTROGEN REPLACEMENT AND COMPLICATIONS OF AMENORRHEA
    Michelle Warren; Fiscal Year: 1992
    ....
  62. ENDOGENOUS ESTROGENS AND ENDOMETRIAL CANCER
    Anne Zeleniuch Jacquotte; Fiscal Year: 1999
    ..In postmenopausal women, estrogen replacement therapy is associated with an increased risk of endometrial cancer...
  63. LEVORMELOXIFENE EFFECTS ON CORONARY ATHEROSCLEROSIS
    James Goodrich; Fiscal Year: 1999
    b>Estrogen replacement therapy (ERT) in the form of conjugated equine estrogens (CEE) is one of the most commonly prescribed medications for post-menopausal women at risk for atherosclerosis and osteoporosis...
  64. ESTROGEN AND EXERCISE--VASCULAR BENEFITS AFTER MENOPAUSE
    KIMBERLY BROWNLEY; Fiscal Year: 2004
    ..abstract_text> ..