hormone replacement therapy

Summary

Summary: Therapeutic use of hormones to alleviate the effects of hormone deficiency.

Top Publications

  1. ncbi Effect of long-term hormone replacement therapy on coronary endothelial function in postmenopausal women
    Sean C Halligan
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:1514-20. 2004
  2. ncbi Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    JAMA 304:1684-92. 2010
  3. ncbi Hormone replacement therapy and the risk of breast cancer
    Steven A Narod
    Women s College Research Institute, Toronto, ON M5A 2T3, Canada
    Nat Rev Clin Oncol 8:669-76. 2011
  4. ncbi National Osteoporosis Society's Position statement on hormone replacement therapy in the prevention and treatment of osteoporosis
    C E Bowring
    National Osteoporosis Society, Bath, UK
    Menopause Int 17:63-5. 2011
  5. ncbi Epidemiology of breast cancer
    T J Key
    Imperial Cancer Research Fund Cancer Epidemiology Unit, University of Oxford, UK
    Lancet Oncol 2:133-40. 2001
  6. ncbi Brain glucose metabolism in hypothyroidism: a positron emission tomography study before and after thyroid hormone replacement therapy
    M Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus Dresden, Technische Universitat Dresden, Fetscherstrasse 74, Dresden, Germany
    J Clin Endocrinol Metab 94:2922-9. 2009
  7. ncbi Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis
    Andrea M Isidori
    Cattedra di Andrologia, Universita La Sapienza, Rome, Italy
    Clin Endocrinol (Oxf) 63:280-93. 2005
  8. ncbi Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    D Kapoor
    Centre for Diabetes and Endocrinology, Barnsley NHS Foundation Trust Hospital, Gawber Road, Barnsley S75 2EP, UK
    Eur J Endocrinol 154:899-906. 2006
  9. ncbi The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
    Chris J Malkin
    Cardiology Department, Royal Hallamshire Hospital, Sheffield, United Kingdom S10 2JF
    J Clin Endocrinol Metab 89:3313-8. 2004
  10. ncbi Hormone replacement therapy and lung cancer risk: a case-control analysis
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:113-23. 2004

Research Grants

Detail Information

Publications312 found, 100 shown here

  1. ncbi Effect of long-term hormone replacement therapy on coronary endothelial function in postmenopausal women
    Sean C Halligan
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:1514-20. 2004
    To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function.
  2. ncbi Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
    JAMA 304:1684-92. 2010
    ..7-8.6 years) and a mean follow-up of 7.9 (SD, 1.4) years, breast cancer incidence was increased among women who received combined hormone therapy. Breast cancer mortality among participants in the trial has not been previously reported...
  3. ncbi Hormone replacement therapy and the risk of breast cancer
    Steven A Narod
    Women s College Research Institute, Toronto, ON M5A 2T3, Canada
    Nat Rev Clin Oncol 8:669-76. 2011
    b>Hormone replacement therapy (HRT) is given to relieve the climacteric symptoms of menopause. Use of HRT reduced after a report from the Women's Health Initiative linked it to an increased risk of breast cancer...
  4. ncbi National Osteoporosis Society's Position statement on hormone replacement therapy in the prevention and treatment of osteoporosis
    C E Bowring
    National Osteoporosis Society, Bath, UK
    Menopause Int 17:63-5. 2011
    b>Hormone replacement therapy (HRT) has been shown to increase bone density, reduce the risk of fracture and can successfully relieve menopausal symptoms...
  5. ncbi Epidemiology of breast cancer
    T J Key
    Imperial Cancer Research Fund Cancer Epidemiology Unit, University of Oxford, UK
    Lancet Oncol 2:133-40. 2001
    ..Alcohol increases risk, whereas physical activity is probably protective. Mutations in certain genes greatly increase breast-cancer risk, but these account for a minority of cases...
  6. ncbi Brain glucose metabolism in hypothyroidism: a positron emission tomography study before and after thyroid hormone replacement therapy
    M Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus Dresden, Technische Universitat Dresden, Fetscherstrasse 74, Dresden, Germany
    J Clin Endocrinol Metab 94:2922-9. 2009
    ..Hypothyroidism is frequently associated with subtle behavioral and psychiatric symptoms. The consequences of inadequate thyroid hormone availability to brain metabolism are poorly understood...
  7. ncbi Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis
    Andrea M Isidori
    Cattedra di Andrologia, Universita La Sapienza, Rome, Italy
    Clin Endocrinol (Oxf) 63:280-93. 2005
    ....
  8. ncbi Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    D Kapoor
    Centre for Diabetes and Endocrinology, Barnsley NHS Foundation Trust Hospital, Gawber Road, Barnsley S75 2EP, UK
    Eur J Endocrinol 154:899-906. 2006
    ..We investigated the effect of testosterone treatment on insulin resistance and glycaemic control in hypogonadal men with type 2 diabetes...
  9. ncbi The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
    Chris J Malkin
    Cardiology Department, Royal Hallamshire Hospital, Sheffield, United Kingdom S10 2JF
    J Clin Endocrinol Metab 89:3313-8. 2004
    ....
  10. ncbi Hormone replacement therapy and lung cancer risk: a case-control analysis
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:113-23. 2004
    To date, there are few published data regarding the use of hormone replacement therapy (HRT) and lung cancer risk...
  11. ncbi Breast cancer incidence, 1980-2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status
    Andrew G Glass
    Oncology Research, Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave, Portland, OR 97227, USA
    J Natl Cancer Inst 99:1152-61. 2007
    ..We examined the potential association between menopausal hormone therapy use and recent changes in breast cancer incidence...
  12. ncbi Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial
    Louise Lind Schierbeck
    Department of Endocrinology, Hvidovre Hospital, Kettegard Alle 30, 2650 Hvidovre, Denmark
    BMJ 345:e6409. 2012
    To investigate the long term effect of hormone replacement therapy on cardiovascular outcomes in recently postmenopausal women.
  13. ncbi DHEA in elderly women and DHEA or testosterone in elderly men
    K Sreekumaran Nair
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 355:1647-59. 2006
    ..Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown...
  14. ncbi Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 27:597-604. 2011
    ..There is no correlation between hormone replacement therapy and cervical cancer...
  15. ncbi Hormonal and reproductive factors in relation to melanoma in women: current review and meta-analysis
    Sara Gandini
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Eur J Cancer 47:2607-17. 2011
    ..This study confirmed no increased risk of CM with the use of oral contraceptives and hormone replacement therapy: exogenous female hormones do not contribute to an increased risk of CM...
  16. ncbi Brain tumors and hormonal factors: review of the epidemiological literature
    Anne Cowppli-Bony
    Laboratoire Santé Travail Environnement, Institut de Santé Publique d Epidémiologie et de Développement, IFR 99, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Cancer Causes Control 22:697-714. 2011
    ..To date, the etiology of primary tumors of the central nervous system (mainly gliomas and meningiomas) is poorly understood. The role of sex hormones has been suggested, based on clinical, experimental, biological, and epidemiological data...
  17. ncbi Hormone replacement therapy use and variations in the risk of breast cancer
    L Opatrny
    Division of Internal Medicine, Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
    BJOG 115:169-75; discussion 175. 2008
    To determine the effect of different types and formulations of hormone replacement therapy (HRT) on the risk of breast cancer in postmenopausal women.
  18. ncbi Individual and combined effects of age, breast density, and hormone replacement therapy use on the accuracy of screening mammography
    Patricia A Carney
    Department of Community and Family Medicine, Dartmouth Medical School, 1 Medical Center Drive, HB 7925, Lebanon, NH 03756, USA
    Ann Intern Med 138:168-75. 2003
    The relationships among breast density, age, and use of hormone replacement therapy (HRT) in breast cancer detection have not been fully evaluated.
  19. ncbi Overall and cause-specific mortality in GH-deficient adults on GH replacement
    Rolf C Gaillard
    Department of Endocrinology, Diabetology and Metabolism, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Endocrinol 166:1069-77. 2012
    ..The purpose of this study was to evaluate mortality and associated factors within a large GH-replaced population of hypopituitary patients...
  20. ncbi Hormonal factors and risk of lung cancer among women?
    Michaela Kreuzer
    Institute of Radiation Hygiene, BfS Federal Office for Radiation Protection, Neuherberg, Germany
    Int J Epidemiol 32:263-71. 2003
    ..This study examines endocrine factors and risk of lung cancer among women by smoking status and histology...
  21. ncbi Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis
    Roger Abs
    Department of Endocrinology, University Hospital, Antwerp, Belgium
    Eur J Endocrinol 155:79-90. 2006
    ..The aim of the present study was to clarify the relationship between GH deficiency (GHD) and some cardiovascular risk factors and to analyse the effect of GH replacement therapy in a large number of patients over a prolonged period of time...
  22. ncbi Transdermal and oral hormone replacement therapy and the risk of stroke: a nested case-control study
    Christel Renoux
    McGill Pharmacoepidemiology Research Unit, Center for Clinical Epidemiology, Jewish General Hospital, Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada H3T 1E2
    BMJ 340:c2519. 2010
    To determine the risk of stroke associated with oral and transdermal routes of administration of hormone replacement therapy.
  23. ncbi Effect of thyroxine replacement on creatinine, insulin-like growth factor 1, acid-labile subunit, and vascular endothelial growth factor
    Christoph Schmid
    Department of Internal Medicine, Division of Endocrinology and Diabetes, University Hospital of Zurich, CH 8091 Zurich, Switzerland
    Clin Chem 50:228-31. 2004
  24. ncbi Pharmacokinetics of transdermal testosterone gel in hypogonadal men: application of gel at one site versus four sites: a General Clinical Research Center Study
    C Wang
    Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
    J Clin Endocrinol Metab 85:964-9. 2000
    ..Dose-ranging studies are required to determine dosage regimens for T gel application as a replacement therapy in hypogonadal men...
  25. ncbi Estrogens in the causation of breast, endometrial and ovarian cancers - evidence and hypotheses from epidemiological findings
    I Persson
    Department of Medical Epidemiology, Karolinska Institutet, 171 77, Stockholm, Sweden
    J Steroid Biochem Mol Biol 74:357-64. 2000
    ..Research has yet to define how some of the risk factors can be modified or treatment regimens can be improved to reduce these cancer risks...
  26. ncbi A pilot study comparing the clinical effects of Jia-Wey Shiau-Yau San, a traditional Chinese herbal prescription, and a continuous combined hormone replacement therapy in postmenopausal women with climacteric symptoms
    Lih Chi Chen
    Department of Pharmacy, Veterans General Hospital Taipei, No 201, Sec 2, Shih Pai Road, 112, Taipei, Taiwan, ROC
    Maturitas 44:55-62. 2003
    ..controlled pilot study was performed to evaluate the clinical effects of JWSYS compared with those of a continuous combined hormone replacement therapy, Premelle, on quality of life in non-hysterectomized postmenopausal women.
  27. pmc A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine
    Vijay Panicker
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 93:3075-81. 2008
    ..We aimed to thoroughly examine the role of common variation across the three deiodinase genes in relation to thyroid hormones...
  28. ncbi Treatment of postmenopausal osteoporosis
    Pierre D Delmas
    Claude Bernard University of Lyon and INSERM Research Unit 403, France
    Lancet 359:2018-26. 2002
    ..b>Hormone replacement therapy remains a valuable option for the prevention of osteoporosis in early postmenopausal women...
  29. ncbi The effects of different hormone replacement therapy regimens on tear function, intraocular pressure and lens opacity
    Gurkan Uncu
    Department of Obstetrics and Gynecology, Uludag University, Faculty of Medicine, Gorukle Bursa, Turkey
    Gynecol Endocrinol 22:501-5. 2006
    ..The aim of the present study was to elucidate the effects of different hormone replacement therapy (HRT) protocols on tear function, IOP and lens opacity.
  30. ncbi Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort
    Agnes Fournier
    Equipe E3N, Institut National de la Sante et de la Recherche Medicale INSERM, Villejuif, France
    Int J Cancer 114:448-54. 2005
    Most epidemiological studies have shown an increase in breast cancer risk related to hormone replacement therapy (HRT) use...
  31. ncbi Increased risk of breast cancer following different regimens of hormone replacement therapy frequently used in Europe
    Claudia Stahlberg
    Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Int J Cancer 109:721-7. 2004
    Epidemiologic studies have shown an increased risk of breast cancer following hormone replacement therapy (HRT)...
  32. ncbi Association of hormone replacement therapy to estrogen and progesterone receptor status in invasive breast carcinoma
    Wendy Y Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer 101:1490-500. 2004
    Observational studies and randomized trials have demonstrated that hormone replacement therapy (HRT) increases the recipient's risk of developing breast carcinoma...
  33. ncbi Improved insulin sensitivity, preserved beta cell function and improved whole-body glucose metabolism after low-dose growth hormone replacement therapy in adults with severe growth hormone deficiency: a pilot study
    A M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Diabetologia 53:1304-13. 2010
    ..We postulated that long-term low-dose growth hormone replacement, restoring IGF-1 to the low-normal range, might beneficially affect glucose metabolism...
  34. ncbi Intrinsic imperfections of endocrine replacement therapy
    J A Romijn
    Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Endocrinol 149:91-7. 2003
    ..Appreciation of these intrinsic shortcomings of endocrine therapy is of utmost importance to prevent incorrect labelling of the complaints of many endocrine patients and to achieve further improvement in endocrine replacement strategies...
  35. ncbi Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial
    Marc R Blackman
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    JAMA 288:2282-92. 2002
    ..Hormone administration to elderly individuals can increase lean body mass (LBM) and decrease fat, but interactive effects of growth hormone (GH) and sex steroids and their influence on strength and endurance are unknown...
  36. pmc Menopausal hormone therapy does not influence lung cancer risk: results from the California Teachers Study
    Jessica Clague
    Department of Population Sciences, Division of Cancer Etiology, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer Epidemiol Biomarkers Prev 20:560-4. 2011
    ..Results from studies examining the association between hormone therapy (HT) and lung cancer risk disagree...
  37. ncbi Reproductive factors, hormone use, estrogen receptor expression and risk of non small-cell lung cancer in women
    Ann G Schwartz
    Population Studies and Prevention Program, Karmanos Cancer Institute, 110 E Warren Ave, Detroit, MI 48201, USA
    J Clin Oncol 25:5785-92. 2007
    ..We also evaluated whether risk factors were differentially associated with cytoplasmic ER-alpha and/or nuclear ER-beta expression-defined NSCLC in postmenopausal women...
  38. ncbi Hormone replacement therapy and incidence of acute myocardial infarction. A population-based nested case-control study
    C Varas-Lorenzo
    Global Epidemiology, Development, Novartis Farmaceutica, S A Barcelona, Spain
    Circulation 101:2572-8. 2000
    ..Epidemiological studies suggest a decreased risk of coronary heart disease (CHD) in healthy women taking hormonal replacement therapy (HRT). Whether this effect is shared by oral and transdermal preparations is unknown...
  39. ncbi Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis
    K Nanda
    Center for Health Services Research in Primary Care, Durham Veterans Administration Medical Center, North Carolina, USA
    Obstet Gynecol 93:880-8. 1999
    To review systematically the association between hormone replacement therapy (HRT) and the risk of developing or dying from colorectal cancer.
  40. ncbi Risk factors and risk reduction of breast and ovarian cancer
    Cecile T M Brekelmans
    Department of Medical Oncology, Erasmus MC Daniel den Hood, Rotterdam, The Netherlands
    Curr Opin Obstet Gynecol 15:63-8. 2003
    ..Breast and ovarian cancer remain a significant burden for women living in the Western world. This paper reviews the risk factors and current strategies to prevent these diseases...
  41. pmc Joint associations between genetic variants and reproductive factors in glioma risk among women
    Sophia S Wang
    Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and the City of Hope, Duarte, CA 91010, USA
    Am J Epidemiol 174:901-8. 2011
    ..These results require replication, but if confirmed, they would suggest that the gene variants that have previously been implicated in the development of glioma are unlikely to act through the same hormonal mechanisms in women...
  42. ncbi A prospective study of different types of hormone replacement therapy use and the risk of subsequent breast cancer: the women's health in the Lund area (WHILA) study (Sweden)
    Helena Jernstrom
    Department of Oncology, The Jubileum Institute, Lund University Hospital, S 221 85 Lund, Sweden
    Cancer Causes Control 14:673-80. 2003
    Reports suggest that combined estrogen plus progestin hormone replacement therapy (HRT) confers a higher breast cancer risk than estrogen alone. We aimed to establish whether breast cancer risk depends on the type of HRT formula.
  43. pmc Reproductive and hormonal factors and the risk of nonsmall cell lung cancer
    Cari L Meinhold
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Int J Cancer 128:1404-13. 2011
    ..Other reproductive and hormonal exposures, including menopausal hormone therapy use, were not associated with risk...
  44. ncbi Hormone replacement therapy and lung cancer risk in Chinese
    Kuan Yu Chen
    Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Cancer 110:1768-75. 2007
    The association between hormone replacement therapy (HRT) and a reduced lung cancer risk has been reported in previous studies...
  45. ncbi Breast tumours following combined hormone replacement therapy express favourable prognostic factors
    Signe Borgquist
    Department of Laboratory Medicine, Division of Pathology, Malmo University Hospital, Lund University, SE 20502 Malmo, Sweden
    Int J Cancer 120:2202-7. 2007
    The aim of the present study was to evaluate the association between different types of hormone replacement therapy (HRT) and risk of specific breast cancer subgroups...
  46. ncbi Ten years of growth hormone (GH) replacement normalizes muscle strength in GH-deficient adults
    Galina Götherström
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Endocrinol Metab 94:809-16. 2009
    ..0 yr; range 22-74 yr) with adult-onset GH deficiency...
  47. ncbi Hormone replacement therapy and endometrial cancer in Ontario, Canada
    M G Jain
    Department of Public Health Sciences, University of Toronto, 308 12 Queen s Park Crescent West, Toronto, Ontario, Canada
    J Clin Epidemiol 53:385-91. 2000
    ..21, 95% CI 1.03-1. 42). The effect of opposed hormone therapy on endometrial cancer risk appears to vary both by usage patterns and by patient characteristics of body weight and history of diabetes...
  48. ncbi Healthcare utilization, quality of life and patient-reported outcomes during two years of GH replacement therapy in GH-deficient adults--comparison between Sweden, The Netherlands and Germany
    Bernhard Saller
    Medical Department, Pfizer GmbH, Karlsruhe, Karlsruhe, Germany
    Eur J Endocrinol 154:843-50. 2006
    ..This study set out to determine the change in quality of life (QoL) and healthcare utilization during 2 years of growth hormone (GH) replacement therapy in adults with GH deficiency. Data were compared from three European countries...
  49. ncbi Hormone replacement therapy and risk of meningioma in women: a meta-analysis
    Zuo Xu Fan
    Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, No 79, Qingchun Road, Hangzhou, 310000, People s Republic of China
    Cancer Causes Control 24:1517-25. 2013
    The relationship between hormone replacement therapy (HRT) and the incidence of meningioma in women has been investigated in several epidemiologic studies, but their results were not entirely consistent...
  50. pmc Effect of hormone replacement therapy on cardiovascular outcomes: a meta-analysis of randomized controlled trials
    Dicheng Yang
    Department of Cardiovascular Surgery, Shanghai First People s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 8:e62329. 2013
    b>Hormone replacement therapy (HRT) is widely used to controlling menopausal symptoms and prevent adverse cardiovascular events. However, the benefit and risk of HRT on cardiovascular outcomes remains controversial.
  51. ncbi Prevalence and incidence of diabetes mellitus in adult patients on growth hormone replacement for growth hormone deficiency: a surveillance database analysis
    Andrea F Attanasio
    Cascina del Rosone, 14041 Agliano Terme, Italy
    J Clin Endocrinol Metab 96:2255-61. 2011
    ..GH replacement in adult GH-deficient patients may cause insulin resistance, raising concerns of potential increased risk of developing diabetes mellitus (DM)...
  52. ncbi Intellectual and motor development of young adults with congenital hypothyroidism diagnosed by neonatal screening
    M J E Kempers
    Emma Children s Hospital Academic Medical Center, Department of Pediatric Endocrinology, Academic Medical Center, University of Amsterdam, G8 205, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Endocrinol Metab 91:418-24. 2006
    ..Hence, it is still unclear whether the frequently reported cognitive and motor deficits observed during childhood persist in adulthood...
  53. ncbi Does growth hormone replacement therapy reduce mortality in adults with growth hormone deficiency? Data from the Dutch National Registry of Growth Hormone Treatment in adults
    Christa C van Bunderen
    Department of Internal Medicine, Section Endocrinology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    J Clin Endocrinol Metab 96:3151-9. 2011
    ..Adults with GH deficiency (GHD) have a decreased life expectancy. The effect of GH treatment on mortality remains to be established...
  54. ncbi Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3'-triiodothyronine therapy
    Bente C Appelhof
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, F5 171, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:6296-9. 2005
    ..Levothyroxine-treated patients can be assumed to derive T3 exclusively from deiodination of T4, which, in the central nervous system, is regulated by type II deiodinase (DII)...
  55. ncbi Efficacy and tolerability of an individualized dosing regimen for adult growth hormone replacement therapy in comparison with fixed body weight-based dosing
    Andrew R Hoffman
    Medical Service, Veterans Affairs Palo Alto Health Care System and Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Clin Endocrinol Metab 89:3224-33. 2004
    ..We conclude that GH replacement therapy should be initiated at a low dose and titrated to a dose producing maximal benefits without adverse side effects and an IGF-I level within the age- and sex-adjusted normal range...
  56. ncbi Baseline characteristics and the effects of five years of GH replacement therapy in adults with GH deficiency of childhood or adulthood onset: a comparative, prospective study
    J Koranyi
    Research Centre for Endocrinology and Metabolism, Grona Straket 8, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    J Clin Endocrinol Metab 86:4693-9. 2001
    ..The 5-yr GH replacement eliminated all the anthropodometric and metabolic differences between the two groups...
  57. ncbi Comparative results of a 4-year study on cardiovascular parameters, lipid metabolism, body composition and bone mass between untreated and treated adult growth hormone deficient patients
    H L Fideleff
    Endocrinology Unit Department of Medicine, Hospital T Alvarez, Aranguren 2701 C1406FWY, Buenos Aires, Argentina
    Growth Horm IGF Res 18:318-24. 2008
    ....
  58. ncbi Effects of 10 years of growth hormone (GH) replacement therapy in adult GH-deficient men
    Lucia I Arwert
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 63:310-6. 2005
    ..GH-deficient adults have changes in body composition, bone mineral density (BMD) and lipid profile that can be altered by GH substitution. However, long-term data on GH substitution (up to 10 years of follow-up) are limited...
  59. pmc A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement
    Peter N Taylor
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Bristol BS1 3NY, UK
    Eur J Endocrinol 164:773-80. 2011
    ..Furthermore, the stability of the association has not been examined in longitudinal studies or in patients on levothyroxine (l-T(4))...
  60. ncbi Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone
    Hector F Escobar-Morreale
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Ann Intern Med 142:412-24. 2005
    ..Substituting part of the dose of l-thyroxine with small but supraphysiologic doses of liothyronine in hypothyroid patients has yielded conflicting results...
  61. pmc Fifteen years of GH replacement increases bone mineral density in hypopituitary patients with adult-onset GH deficiency
    Mariam Elbornsson
    Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Grona Straket 8, SE 413 45 Goteborg, Sweden
    Eur J Endocrinol 166:787-95. 2012
    ..Few studies have determined the effects of more than 5-10 years of GH replacement in adults on bone mineral content (BMC) and bone mineral density (BMD)...
  62. ncbi Favorable long-term effects of growth hormone replacement therapy on quality of life, bone metabolism, body composition and lipid levels in patients with adult-onset growth hormone deficiency
    A P Jørgensen
    Section of Endocrinology, Oslo University Hospital, Faculty of Medicine, University of Oslo, Norway
    Growth Horm IGF Res 21:69-75. 2011
    ....
  63. ncbi Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients
    Vijay Panicker
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 94:1623-9. 2009
    ..We hypothesized that in patients on T(4) common variants in the deiodinase genes might influence baseline psychological well-being and any improvement on combined T(4)/T(3) without necessarily affecting serum thyroid hormone levels...
  64. ncbi Fracture incidence in GH-deficient patients on complete hormone replacement including GH
    Helene Holmer
    Department of Internal Medicine, Centralsjukhuset, Kristianstad, Sweden
    J Bone Miner Res 22:1842-50. 2007
    ..Studying fracture incidence in 832 patients on GH therapy and 2581 matched population controls, we recorded a doubled fracture risk in CO GHD women, but a significantly lower fracture risk in AO GHD men...
  65. ncbi Does hormone replacement therapy cause breast cancer? An application of causal principles to three studies: part 3. The Women's Health Initiative: unopposed estrogen
    Samuel Shapiro
    Department of Epidemiology, University of Cape Town, Cape Town, South Africa
    J Fam Plann Reprod Health Care 37:225-30. 2011
    ..Studies from the Women's Health Initiative have reported an increased risk of breast cancer in users of estrogen plus progestogen. Among users of estrogen alone an increased risk was not observed...
  66. ncbi Case-control study of anthropometric measures and breast cancer risk
    Christine M Friedenreich
    Division of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Canada
    Int J Cancer 99:445-52. 2002
    ..Statistically significant trends in risk were observed for these variables. Effect modification with hormone replacement therapy use was found for most variables assessed for postmenopausal women, with much stronger associations ..
  67. pmc Timing of levothyroxine administration affects serum thyrotropin concentration
    Thien Giang Bach-Huynh
    Division of Endocrinology, Georgetown University Medical Center, Washington, DC 20007, USA
    J Clin Endocrinol Metab 94:3905-12. 2009
    ..Patients treated with levothyroxine typically ingest it in a fasting state to prevent food impairing its absorption. The serum thyrotropin concentration is the therapeutic index of levothyroxine action...
  68. pmc Partisan perspectives in the medical literature: a study of high frequency editorialists favoring hormone replacement therapy
    Athina Tatsioni
    Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Gen Intern Med 25:914-9. 2010
    Unfavorable results of major studies have led to a large shrinkage of the market for hormone replacement therapy (HRT) in the last 6 years. Some scientists continue to strongly support the use of HRT.
  69. ncbi What is the optimal therapy for young males with hypogonadotropic hypogonadism?
    T S Han
    Centre for Neuroendocrinology, University College London Medical School, Royal Free Hospital, Hampstead, London NW3 2PF, UK
    Clin Endocrinol (Oxf) 72:731-7. 2010
    ..Reversible genetic hypogonadotropic hypogonadism' is a recently described entity which has implications for the long-term management of patients with HH...
  70. ncbi Clinical review: Why is androgen replacement in males controversial?
    Glenn R Cunningham
    Baylor College of Medicine and St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 96:38-52. 2011
    ..The clinician must be able to counsel patients to help them determine whether testosterone replacement therapy is appropriate for them...
  71. ncbi Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor
    S Begliuomini
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Hum Reprod 22:995-1002. 2007
    ..Brain-derived neurotrophic factor (BDNF) is a mediator of neuronal plasticity and influences learning, memory and cognitive behaviour. The aim of this study is to assess plasma BDNF variations according to hormonal status...
  72. pmc Oesophageal cancer in women: tobacco, alcohol, nutritional and hormonal factors
    S Gallus
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan, 20157, Italy
    Br J Cancer 85:341-5. 2001
    ..The multivariate odds ratio was 4.5 for heavy smoking and 5.4 for heavy alcohol drinking. Fruit intake, vegetable intake, oral contraceptive and HRT use were inversely related to oesophageal cancer...
  73. ncbi Thyroid hormone replacement therapy
    W M Wiersinga
    Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, NL 1105 AZ Amsterdam, The Netherlands
    Horm Res 56:74-81. 2001
    ..It could well be that a slow-release preparation containing both T(4) and T(3) might improve the quality of life, compared with T(4) replacement alone, in some hypothyroid patients...
  74. ncbi Postmenopausal hormone replacement therapy: effects on normal mammary gland in humans and in a mouse postmenopausal model
    Sandra Z Haslam
    Department of Physiology, Michigan State University, East Lansing 48824, USA
    J Mammary Gland Biol Neoplasia 7:93-105. 2002
    ..The purpose of this review article is to examine the evidence for the effects of hormone replacement therapy in its various forms on the biology of the postmenopausal breast both in humans and in an animal model, ..
  75. ncbi Weight change and the risk of late-onset breast cancer in the original Framingham cohort
    Kathy L Radimer
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    Nutr Cancer 49:7-13. 2004
    ..This study assesses the relation of adult weight change overall and at specific, hormonally relevant times with diagnosis of a first breast cancer after age 55 (late onset)...
  76. ncbi Testosterone deficiency
    Abdulmaged M Traish
    Department of Biochemistry, Division of Urology, Boston University School of Medicine, Mass, USA
    Am J Med 124:578-87. 2011
    ..This review examines a host of studies, with practical recommendations for diagnosis of TD and T repletion in middle-aged and older men, including an analysis of treatment modalities and areas of concerns and uncertainty...
  77. ncbi Body mass index, hormone replacement therapy, and endometrial cancer risk: a meta-analysis
    Emma J Crosbie
    Gynaecology Oncology Research Group, School of Cancer and enabling Sciences, University of Manchester, Manchester, UK
    Cancer Epidemiol Biomarkers Prev 19:3119-30. 2010
    Body mass index (BMI) is a risk factor for endometrial cancer. We quantified the risk and investigated whether the association differed by use of hormone replacement therapy (HRT), menopausal status, and histologic type.
  78. ncbi Hormone replacement therapy and incidence of hormone-dependent cancers in the Norwegian Women and Cancer study
    Kjersti Bakken
    Department of Community Medicine, University of Tromsø, Tromsø, Norway
    Int J Cancer 112:130-4. 2004
    ..Our results suggest that HRT could be considered a major determinant for the increasing incidence of breast cancer in Norway...
  79. ncbi Prostate-specific antigen changes and prostate cancer in hypogonadal men treated with testosterone replacement therapy
    Robert M Coward
    Division of Urologic Surgery, The University of North Carolina, Chapel Hill, NC, USA
    BJU Int 103:1179-83. 2009
    ....
  80. ncbi Hormone replacement therapy and cancer risk
    V Mahavni
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Curr Opin Oncol 13:384-9. 2001
    The advantages and disadvantages of hormone replacement therapy (HRT) have been debated nearly as long as the treatment has been in use, especially the relationship between HRT and risk of cancer development...
  81. ncbi One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults
    Cesar L Boguszewski
    SEMPR, Serviço de Endocrinologia e Metobologia do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil
    Eur J Endocrinol 152:67-75. 2005
    ..We have studied the effects on body composition and metabolism of a fixed low dose of growth hormone (GH), 0.6 IU (0.2 mg)/day, administered for 12 months to GH-deficient (GHD) adults...
  82. ncbi Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study
    Heather Spencer Feigelson
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta Georgia 30329, USA
    Cancer Epidemiol Biomarkers Prev 13:220-4. 2004
    Excess adiposity and hormone replacement therapy (HRT) are important contributors to postmenopausal breast cancer risk...
  83. ncbi Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease: effects on bone
    Kristian Løvås
    Institute of Medicine, University of Bergen, 5020 Bergen, Norway Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway
    Eur J Endocrinol 160:993-1002. 2009
    ..Context Patients with primary adrenal insufficiency (Addison's disease) receive more glucococorticoids than the normal endogenous production, raising concern about adverse effects on bone...
  84. ncbi Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy
    Fabio Lanfranco
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    Clin Endocrinol (Oxf) 60:500-7. 2004
    ..This study aimed to evaluate adiponectin levels in hypogonadal men prior to and during testosterone replacement therapy...
  85. ncbi Carcinogenicity of combined oestrogen-progestagen contraceptives and menopausal treatment
    Vincent Cogliano
    Lancet Oncol 6:552-3. 2005
  86. ncbi Serum CrossLaps for monitoring the response in individuals undergoing antiresorptive therapy
    S Christgau
    Osteometer BioTech A S, Osteopark, Herlev, Denmark
    Bone 26:505-11. 2000
    ..to monitor individual responses to antiresorptive therapy was assessed in studies of the effects of hormone replacement therapy (HRT) and bisphosphonate (alendronate)...
  87. pmc Androgen treatment and muscle strength in elderly men: A meta-analysis
    Kenneth J Ottenbacher
    Division of Rehabilitation Sciences, Sealy Center on Aging, Houston, Texas, USA
    J Am Geriatr Soc 54:1666-73. 2006
    ..To review published, randomized trials examining the effect of androgen treatment on muscle strength in older men...
  88. ncbi Ten-year GH replacement increases bone mineral density in hypopituitary patients with adult onset GH deficiency
    G Götherström
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Grona Straket 8, SE 413 45 Goteborg, Sweden
    Eur J Endocrinol 156:55-64. 2007
    ..The results show that GH replacement induced a sustained increase in BMD at all the skeletal sites measured...
  89. ncbi Effect of climacteric transition and hormone replacement therapy on body weight and body fat distribution
    Andrea Riccardo Genazzani
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 22:145-50. 2006
    ..postmenopausal (n = 885), and compared them with 354 postmenopausal women receiving different forms of hormone replacement therapy (HRT)...
  90. ncbi Testosterone treatment comes of age: new options for hypogonadal men
    Eberhard Nieschlag
    Institute of Reproductive Medicine of the University of Münster WHO Collaboration Centre for Research in Male Reproduction, Munster, Germany
    Clin Endocrinol (Oxf) 65:275-81. 2006
    ..Based on pharmacogenetic considerations taking the androgen receptor polymorphism into account, treatment may be individualized for each patient in the future...
  91. ncbi The effect of 30 months of low-dose replacement therapy with recombinant human growth hormone (rhGH) on insulin and C-peptide kinetics, insulin secretion, insulin sensitivity, glucose effectiveness, and body composition in GH-deficient adults
    A M Rosenfalck
    Department of Internal Medicine and Endocrinology, Hvidovre University Hospital, Copenhagen, Denmark
    J Clin Endocrinol Metab 85:4173-81. 2000
    ..Therefore, rhGH treatment may precipitate diabetes in some patients already susceptible to the disorder...
  92. ncbi Gonadal steroid replacement reverses gonadectomy-induced changes in the corticosterone pulse profile and stress-induced hypothalamic-pituitary-adrenal axis activity of male and female rats
    J V Seale
    LINE, Dorothy Hodgkin Building, Whitson Street, University of Bristol, Bristol, UK
    J Neuroendocrinol 16:989-98. 2004
    ..These data demonstrate a major contribution of gonadal steroids to the regulation of HPA axis activity and to the pulsatile characteristics of corticosterone release...
  93. pmc Health related quality of life after combined hormone replacement therapy: randomised controlled trial
    Amanda J Welton
    MRC General Practice Research Framework, Stephenson House, London NW1 2ND
    BMJ 337:a1190. 2008
    To assess the effect of combined hormone replacement therapy (HRT) on health related quality of life.
  94. ncbi A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices
    G Götherström
    Research Centre for Endocrinology and Metabolism, Grona Straket 8, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    J Clin Endocrinol Metab 86:4657-65. 2001
    ..The effects on body composition and low density lipoprotein cholesterol were seen after 1 yr, whereas the effects on bone mass, triglycerides, and hemoglobin A(1c) were first observed after years of treatment...
  95. ncbi Effect of leptin replacement on brain structure in genetically leptin-deficient adults
    John A Matochik
    Neuroimaging Research Branch, National Institute on Drug Abuse, Department of Health and Human Services National Institutes of Health, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 90:2851-4. 2005
    ..Our findings suggest that leptin can have sustained effects on tissue composition in the human brain and broaden the potential spectrum of leptin's influence beyond feeding behavior and endocrine function...
  96. ncbi Treatment of gonadotropin-deficient boys with recombinant human FSH: long-term observation and outcome
    Taneli Raivio
    Hospital for Children and Adolescents, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Eur J Endocrinol 156:105-11. 2007
    ..One potential cause for this is deficient proliferation of immature Sertoli cells before and during puberty due to the absence of FSH...
  97. ncbi Effects of hormone replacement therapy regimens on mammographic breast density: the role of progestins
    Naile Bolca Topal
    Department of Radiology, Faculty of Medicine, Uludag University, Bursa, Turkey
    J Obstet Gynaecol Res 32:305-8. 2006
    To evaluate the effects of different regimens of hormone replacement therapy (HRT) on mammographic breast density.
  98. ncbi Oral contraceptive use, hormone replacement therapy, reproductive history and risk of colorectal cancer in women
    Geoffrey C Kabat
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY 10461, USA
    Int J Cancer 122:643-6. 2008
    ..However, with respect to exogenous hormones, in contrast to hormone replacement therapy, few cohort studies have examined oral contraceptive use in relation to colorectal cancer risk...
  99. ncbi Effect of testosterone replacement therapy on arterial stiffness in older hypogonadal men
    Marianna Yaron
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 64239
    Eur J Endocrinol 160:839-46. 2009
    ..To assess arterial stiffness in a cohort of hypogonadal males and to investigate the effect of testosterone replacement therapy on arterial properties in this specific group...
  100. pmc Use and discontinuation of hormone replacement therapy in women with myocardial infarction: a nationwide study
    Ditte Marie Bretler
    Department of Cardiology, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, Hellerup, Denmark
    Br J Clin Pharmacol 71:105-15. 2011
    General use of hormone replacement therapy (HRT) dropped drastically after 2002 when pivotal randomized trials showed increased risk of coronary artery disease and other complications with HRT...
  101. ncbi Testosterone, bone and osteoporosis
    Stephen P Tuck
    Department of Rheumatology, James Cook University Hospital, Middlesbrough, UK
    Front Horm Res 37:123-32. 2009
    ..Finally, we review the effects of testosterone replacement in hypogonadism and explore other options for the treatment of osteoporosis secondary to loss of sex steroids in men...

Research Grants67

  1. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..are at high risk for diabetes, and previous studies suggest that endogenous sex hormones (as opposed to hormone replacement therapy) may play a role...
  2. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..Although hormone replacement therapy, alleviates hot flushes in the majority of women, a large number of peri-menopausal women cannot take ..
  3. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The role of hormone action and hormone replacement therapy in vascular biology is an area of intense interest, but remains highly controversial...
  4. Cell Specific Expression in the Pituitary Gland
    Sally A Camper; Fiscal Year: 2013
    ..Treatment involves hormone replacement therapy, which can involve daily injections of recombinant growth hormone at great expense per patient...
  5. Estrogen-T cell Interactions
    Prakash S Nagarkatti; Fiscal Year: 2013
    ..Postmenopausal women administered estrogens in hormone replacement therapy, as well as, several chemicals found in the environment and foods act as estrogens causing significant ..
  6. Estrogen and hippocampal plasticity
    LORI LYNN MCMAHON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The Women's Health Initiative (WHI) reported in 2003-2004 that hormone replacement therapy, either progesterone and estrogen in combination or estrogen alone, provided no cardiovascular or ..
  7. Gender Specific Complications of Diabetic Autonomic Neuropathy: A New Mouse Model
    JONAS BERNARD GALPER; Fiscal Year: 2010
    ..women compared with men;this difference was attenuated after menopause, but maintained in women on hormone replacement therapy (HRT)...
  8. Bone Marrow Adiposity, Bone and Body Composition
    Ann V Schwartz; Fiscal Year: 2012
    ..The study will also evaluate the effect of glucocorticoids, hormone replacement therapy and bisphosphonates on marrow fat in a subset of women (N=45) selected from those who report current ..
  9. A female-specific neuroendocrine center controlling energy expenditure
    STEPHANIE CORREA; Fiscal Year: 2013
    ..b>Hormone replacement therapy (HRT) can curb postmenopausal weight gain but can also increase the risk of stroke and breast cancer...
  10. Cortical Aging, Estrogen and Behavior
    JANICE JURASKA; Fiscal Year: 2009
    ..The third issue concerns the efficacy of hormone replacement therapy including the mode of replacement (chronic vs cyclic hormones) on neural and behavioral aging...
  11. ABC: Antidepressants and Breast Cancer Pharmacoepidemiology
    Reina Haque; Fiscal Year: 2012
    ..quality of life and quality of sleep including hot flashes, night sweats, and depression, and because hormone replacement therapy is contraindicated for women with breast cancer, antidepressants increasingly have been used to relieve ..
  12. Regulation of GPER-mediated Signaling in the Vasculature by Calmodulin
    Kim Tran; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Despite the clear linkage between post menopause and cardiovascular disease, hormone replacement therapy has not proven to be cardio protective...
  13. Vaginal Ring for Preventing Bacterial Vaginosis
    THOMAS RAY MOENCH; Fiscal Year: 2010
    ..Vaginal rings are highly user-acceptable for contraception and for hormone replacement therapy. Thus the BVP-Ring is likely to be user-acceptable, and much more acceptable than frequently applying a ..
  14. Gender Differences in Caloric Restriction Cardioprotection
    Lin Yan; Fiscal Year: 2010
    ..the NIH Women's Health Initiative trial have failed to demonstrate cardioprotective benefit from hormone replacement therapy (HRT) in post- menopausal women...
  15. Relaxin: A Novel HRT for Prevention of Cardiac Disease
    ROLANDO JUAN JOSE RAMIREZ; Fiscal Year: 2011
    ..Therefore, fresh approaches to the concept of "hormone replacement therapy" in postmenopausal women would be useful...
  16. Identification of novel phytoprogestins from hops and red clover
    Joanna E Burdette; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Hormone replacement therapy (HRT) is the most commonly prescribed medication for the alleviation of menopausal symptoms...
  17. Exogenous Testosterone and Risk of Cancer
    SUSAN AUDREY HALL; Fiscal Year: 2012
    ..public health relevance of the proposal is high, given the increasing using of testosterone as 'hormone replacement therapy'and the potential for newly repeating 'the estrogen disaster'among women for prostate ..
  18. Vascular Interactions of Estrogen Receptor GPR30 and the Renin-Angiotensin System
    Sarah Hoffmann Lindsey; Fiscal Year: 2013
    ..from those mediated by its nuclear estrogen receptors may elucidate the current controversy surrounding hormone replacement therapy. The proposal will take a comprehensive approach utilizing an in vitro cell culture system, an ex vivo ..
  19. TXNIP as a Key Regulator of Thyroid Cancer Metabolism and Aggressiveness
    Bryan R Haugen; Fiscal Year: 2013
    ..cancer (DTC) and are managed successfully with a combination of surgery, radioiodine and thyroid hormone replacement therapy. Anaplastic thyroid cancer (ATC), on the other hand, is one of the most aggressive human malignancies ..
  20. Effects of Continuous versus Cyclic Oral Contraceptives on Mammary Tumor Growth
    PATRICIA ANN MASSO-WELCH; Fiscal Year: 2013
    ..Extension of E+P exposure using a widely employed hormone replacement therapy (HRT) increased breast cancer risk in postmenopausal women...
  21. Role of Allopregnanolone in Mediating the Adverse Effects of Psychosocial Stress
    Vasiliki Michopoulos; Fiscal Year: 2010
    ..in ovarian hormone levels, including premenstrual dysphoric disorder, postpartum depression, and hormone replacement therapy induced negative mood...
  22. Estrogen regulation of channels involved in the control of energy homeostasis
    TROY ADAM ROEPKE; Fiscal Year: 2010
    ..ligand for the membrane estrogen receptor, is a potential lead compound for an non-traditional hormone replacement therapy and treatment of obsesity disorders...
  23. Behavioral Treatment of Menopausal Insomnia;Sleep, Depression, Daytime Outcomes
    Christopher L Drake; Fiscal Year: 2013
    ..8 Historically, menopausal symptoms including sleep disturbance, were treated using hormone replacement therapy (HRT)...
  24. Elucidating the mechanism of ERbeta in colon carcinogenesis
    CECILIA MARIE WILLIAMS; Fiscal Year: 2013
    ..However, hormone replacement therapy in women unexpectedly resulted in reduced risk of colorectal cancer, use of oral contraceptives is ..
  25. Biointeractions of antiestrogens with nitric oxide
    Gregory R J Thatcher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Use of estrogen/hormone replacement therapy (HRT) for post-menopausal symptoms has plummeted because of increased breast cancer risk associated with hormonal and chemical carcinogenesis...
  26. Genetic variants in the PI3K pathway in mammographic density and breast cancer
    Cheryl L Thompson; Fiscal Year: 2013
    ..trials showing an unexpected significantly elevated risk of breast cancer among women taking combined hormone replacement therapy (HRT) highlights the important, but under-appreciated, role of progesterone as well as estrogen in the ..
  27. Hypothalamic mechanisms mediating estrogenic regulation of energy homeostasis
    Yong Xu; Fiscal Year: 2012
    ..b>Hormone replacement therapy may be a way to reduce these risks, but actions of estrogen via its receptors in the peripheral tissues ..
  28. Unique cardiovascular Risk Factors in Women Research and Mentoring Progam
    Ellen W Seely; Fiscal Year: 2013
    ..Two unique risk factors for CVD are hormone replacement therapy (HRT) and gestational diabetes (GDM)...
  29. CNS circuits mediating estrogenic regulation on energy and glucose homeostasis
    Yong Xu; Fiscal Year: 2013
    ..b>Hormone replacement therapy may be a way to reduce these risks, but actions of estrogen via its receptors in the peripheral tissues ..
  30. BREAST CANCER SURVEILLANCE IN A DEFINED POPULATION
    DIANA SM BUIST; Fiscal Year: 2011
    ..data file development;2) To use the data system to conduct 5 initiatives: a) The effect of short-term hormone replacement therapy (HRT) cessation on mammographic density;b) The likelihood of additional imaging (mammography and ..
  31. Neurocognitive and Metabolic Effects of Mild Hypothyroidism
    Mary H Samuels; Fiscal Year: 2012
    ..this study has major public health implications for the millions of Americans who receive thyroid hormone replacement therapy, as well as for the additional millions with high-normal serum TSH levels...
  32. Natural History of Stress, Urge and Mixed Urinary Incontinence in Women
    XIAOWEI SHERRY YAN; Fiscal Year: 2013
    ..Risk factors common to stress and urge UI include obesity, parity, hormone replacement therapy, prolapse and others...
  33. ER-Negative, Basal Cells Persist in Luminal Cancers: Are They Cancer Stem Cells?
    James M Haughian; Fiscal Year: 2011
    ..These studies also provide a plausible explanation for why women taking progestins in hormone replacement therapy (HRT) were at a higher risk of getting breast cancer...
  34. Long-term impact of primary hyperparathyroidism on bone density in the elderly
    Michael W Yeh; Fiscal Year: 2012
    ..2. Assess the effect of antiresorptive therapy, hormone replacement therapy, and vitamin D analogues on BMD in these patients. 3...
  35. Combined hormone replacement therapy use in relation to breast cancer mortality.
    Noel S Weiss; Fiscal Year: 2010
    ..by applicant): Project Summary It has become increasingly evident that women who are taking combined hormone replacement therapy (CHRT) are at an increased risk of developing breast cancer, however, the potential impact of this form ..
  36. Pharmaconeuropathology of Brain Aging and Dementia
    Joshua A Sonnen; Fiscal Year: 2013
    ..structural, and biochemical features of dementia in the elderly: "cardioprotective" doses of aspirin, hormone replacement therapy in women, two subclasses of antihypertensive drugs with proposed neuroprotective actions (calcium ..
  37. Menopause: Decreased Response to Increasing Inflammation
    ADRIANA CATERINA MAGGI; Fiscal Year: 2010
    ..prevention of the disorders associated with menopause which are safer and more efficacious than present hormone replacement therapy (HRT)...
  38. Estrogen and Skin Cancer
    Tatiana M Oberyszyn; Fiscal Year: 2011
    ..Studies in post-menopausal women have found that hormone replacement therapy is effective at reversing the dryness and wrinkling that affects aging skin...
  39. PRESCRIPTION PATTERNS & PRACT FOR POSTMEMOPAUSAL THERAPY
    JENNIFER MIGLIONICO; Fiscal Year: 2000
    ..Based on studies conducted in the early 1990s, prevalence estimates for the use of hormone replacement therapy by menopausal women range from 10% to 71% in specific geographic regions of the United States...
  40. Serotonergic Botanicals for Menopausal Treatment
    SHARLA POWELL; Fiscal Year: 2009
    ..These symptoms lead to a negative effect on their quality of life. Hormone replacement therapy (HRT) was originally developed as a means to combat these effects;however, recent studies have shown ..
  41. BIOMEDICAL (BASIC)
    Samir Hanash; Fiscal Year: 2009
    ..Hypotheses to be tested include evidence of hormone replacement therapy (HRT) effect on the risk of smoker and never smoker lung cancer and chronic inflammation as a risk ..
  42. Botanicals from Central America for Menopause
    Gail Mahady; Fiscal Year: 2005
    ..2 billion postmenopausal women worldwide. For many years, hormone replacement therapy (HRT) has been the gold standard for the symptomatic treatment of menopause...
  43. Dietary Isoflavones, Tamoxifen, and Tumor Growth
    William Helferich; Fiscal Year: 2005
    ..Considerable research has focused on the use of hormone replacement therapy (HRT) by women with E-responsive breast cancer and most oncologists/physicians do not recommend HRT to ..
  44. GENETIC SUSCEPTIBILITY TO HORMONAL CARCINOGENESIS
    ROLF PERSSON; Fiscal Year: 2000
    ..late age at first birth, early menarche, late menopause, long-term use of oral contraceptives or hormone replacement therapy-together with first-degree family history, explain only half of all breast cancers occurring...
  45. MUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISM
    Bruce Psaty; Fiscal Year: 2001
    ..observational studies and randomized clinical trials suggest that in post-menopausal women, the use of hormone replacement therapy is associated with a 3-fold increase in VTE risk...
  46. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2004
    The efficacy of hormone replacement therapy (HRT) in preventing postmenopausal bone loss is well-known...
  47. Isomeric HRT estrogen-DNA adducts: Structure and Repair
    Nicholas Geacintov; Fiscal Year: 2009
    A widely used hormone replacement therapy (HRT) formulation (~ 57 million prescriptions in 2003 alone) contains the conjugated equine estrogens equilenin (EN), equilin, and 8,9-dehydro-estrone (total ~ 54% composition), and the ..
  48. Nurses' Health Study: Short Sleep Duration and Risk of Hypertension
    JAMES GANGWISCH; Fiscal Year: 2009
    ..studies on this association did not examine the potential effect modifiers of menopausal status, hormone replacement therapy, and shift work or the potential mediator of snoring...
  49. Estrogen and brain vascular inflammation in diabetics
    Dale Pelligrino; Fiscal Year: 2007
    ..However, clinically, there are indications that hormone replacement therapy in women may not be beneficial, and even detrimental...
  50. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..Since P are widely used in oral contraceptives and in postmenopausal hormone replacement therapy it is critically important that their mechanims of action be understood...
  51. BONE ESTROGEN STRENGTH TRAINING
    Timothy Lohman; Fiscal Year: 2000
    ..trial evaluating the effect of one year of exercise on total body and regional BMD in two population (hormone replacement therapy (HRT) versus no HRT) of postmenopausal women...
  52. Effects of Amino Acid Therapy on Hot Flashes in Postmenopausal Women
    Thomas Guttuso; Fiscal Year: 2007
    ..Although hormone replacement therapy (HRT) is highly effective in reducing hot flashes, long-term HRT is associated with increased rates of ..
  53. EFFECT OF SOYBEANS ON BONE AND THE REPRODUCTIVE TRACT
    JANICE BAHR; Fiscal Year: 2002
    DESCRIPTION: (adapted from the applicant's abstract) Some postmenopausal women use hormone replacement therapy (HRT) to maintain bone. This treatment is, however, not acceptable to all women...
  54. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2006
    ..Furthermore, if associations are causal, understanding whether hormone replacement therapy or other factors significantly modify a menopause-sleep disorder link may lead to interventions that ..
  55. Hormone Replacement Therapy, SERMs & Leg Blood Flow in Postmenopausal Women
    DOUGLAS SEALS; Fiscal Year: 2007
    ..Among postmenopausal women, however, those taking hormone replacement therapy (HRT) had greater LBF and LVC than their estrogen deficient peers...
  56. Population-Based Study of Environmental Risk Factors for ALS
    Marc G Weisskopf; Fiscal Year: 2013
    ..We will also examine whether any of the potential risk factors-in particular, statin or hormone replacement therapy (HRT) use-affect survival with ALS...
  57. HORMONE REPLACEMENT THERAPY AND BREAST CANCER
    Patricia Carney; Fiscal Year: 2004
    The long-term objective of this study is to evaluate the relationships between hormone replacement therapy (HRT) and breast cancer detection, breast cancer risk, breast tumor prognostic characteristics and health-related quality of life...
  58. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
    ..consequently, it is used in the treatment of endometrial cancer and it is an essential component of hormone replacement therapy designed to alleviate post-menopausal symptoms in women...
  59. LONG TERM OUTCOMES FOR WOMEN WITH BREAST CA IN SITU
    Elizabeth Claus; Fiscal Year: 2004
    ..study subjects and include information on family history of cancer, pregnancy and menstrual history, hormone replacement therapy, oral contraceptive use, as well as socio-demographic variables...
  60. MELATONIN FOR SLEEP DISTURBANCES DURING MENOPAUSE
    Andrea Suhner; Fiscal Year: 2001
    ..therapy can alleviate these symptoms, yet side effects and contraindications make the use of this hormone replacement therapy (HRT) problematic in many women. As such, alternatives to traditional HRT are needed...
  61. HORMONE REPLACEMENT AND METABOLIC CARDIOVASCULAR RISK
    Cynthia Sites; Fiscal Year: 2003
    The menopause transition is associated with a pronounced increase in risk of cardiovascular disease. Hormone replacement therapy in postmenopausal women reduces the risk of cardiovascular disease by approximately 50 percent, although ..
  62. POSTMENOPAUSAL HORMONE THERAPY AND INTRA ABDOMINAL FAT
    Barbara Gower; Fiscal Year: 2000
    ..b>Hormone replacement therapy has positive effects on the lipid profile in postmenopausal women, and may affect regional fat ..
  63. Estrogen Receptor-Selective Herbs for Menopause Symptoms
    Dale Leitman; Fiscal Year: 2006
    ..Although these conditions have been effectively treated with hormone replacement therapy (HILT) for the past 50 years, recent clinical trials have found that HRT is associated with increased ..
  64. INHIBITION OF PROGESTIN-DEPENDENT ANGIOGENESIS IN BREAST CANCER
    CANDACE CARROLL; Fiscal Year: 2009
    ..provided by applicant): Millions of postmenopausal women with an intact uterus are prescribed combined hormone replacement therapy (HRT), consisting of both estrogens and progestins, to diminish menopausal symptoms;progestins negate ..
  65. History of Hormone Replacement Therapy, 1960-2000
    Elizabeth Watkins; Fiscal Year: 2005
    ..is to produce the first socio-cultural historical study of the changing rationales for prescribing hormone replacement therapy (HRT) for menopausal and post-menopausal women from the 1960s to the present...
  66. POSTMENOPAUSAL HORMONE REPLACEMENT THERAPY AFTER CABG
    Pamela Ouyang; Fiscal Year: 2001
    ..However the benefit for hormone replacement therapy in women with established coronary disease has not been demonstrated...
  67. ESTROGEN, MUSCLE BLOOD FLOW AND ENOS POST MENOPAUSE
    Robert Hickner; Fiscal Year: 2000
    ..However, postmenopausal women on hormone replacement therapy (HRT) have improved NO induced limb blood flow response at rest...