drug delivery systems

Summary

Summary: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.

Top Publications

  1. ncbi Nanoparticle therapeutics: an emerging treatment modality for cancer
    Mark E Davis
    Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Drug Discov 7:771-82. 2008
  2. pmc Delivering nanomedicine to solid tumors
    Rakesh K Jain
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Nat Rev Clin Oncol 7:653-64. 2010
  3. ncbi Liposomal drug delivery systems: from concept to clinical applications
    Theresa M Allen
    Emeritus, University of Alberta, Canada
    Adv Drug Deliv Rev 65:36-48. 2013
  4. ncbi Drug penetration in solid tumours
    Andrew I Minchinton
    Department of Medical Biophysics, British Columbia Cancer Research Centre, Vancouver, Canada
    Nat Rev Cancer 6:583-92. 2006
  5. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
  6. ncbi Therapeutic nanoparticles for drug delivery in cancer
    Kwangjae Cho
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 14:1310-6. 2008
  7. ncbi Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Adv Drug Deliv Rev 55:329-47. 2003
  8. pmc DrugBank: a knowledgebase for drugs, drug actions and drug targets
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 36:D901-6. 2008
  9. ncbi Relating protein pharmacology by ligand chemistry
    Michael J Keiser
    Department of Pharmaceutical Chemistry, University of California San Francisco, 1700 4th St, San Francisco California 94143 2550, USA
    Nat Biotechnol 25:197-206. 2007
  10. pmc Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
    Omid C Farokhzad
    Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6315-20. 2006

Detail Information

Publications285 found, 100 shown here

  1. ncbi Nanoparticle therapeutics: an emerging treatment modality for cancer
    Mark E Davis
    Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Drug Discov 7:771-82. 2008
    ....
  2. pmc Delivering nanomedicine to solid tumors
    Rakesh K Jain
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Nat Rev Clin Oncol 7:653-64. 2010
    ..Finally, we discuss design considerations for optimizing the delivery of nanoparticles to tumors...
  3. ncbi Liposomal drug delivery systems: from concept to clinical applications
    Theresa M Allen
    Emeritus, University of Alberta, Canada
    Adv Drug Deliv Rev 65:36-48. 2013
    ..closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of countless liposome researchers over almost 5 decades led to the development of ..
  4. ncbi Drug penetration in solid tumours
    Andrew I Minchinton
    Department of Medical Biophysics, British Columbia Cancer Research Centre, Vancouver, Canada
    Nat Rev Cancer 6:583-92. 2006
    ....
  5. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
    b>Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally...
  6. ncbi Therapeutic nanoparticles for drug delivery in cancer
    Kwangjae Cho
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 14:1310-6. 2008
    ..are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability, ..
  7. ncbi Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Adv Drug Deliv Rev 55:329-47. 2003
    ..Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed...
  8. pmc DrugBank: a knowledgebase for drugs, drug actions and drug targets
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 36:D901-6. 2008
    ..DrugBank has also significantly improved the power and simplicity of its structure query and text query searches. DrugBank is available at http://www.drugbank.ca...
  9. ncbi Relating protein pharmacology by ligand chemistry
    Michael J Keiser
    Department of Pharmaceutical Chemistry, University of California San Francisco, 1700 4th St, San Francisco California 94143 2550, USA
    Nat Biotechnol 25:197-206. 2007
    ..These predictions were subsequently confirmed experimentally. Relating receptors by ligand chemistry organizes biology to reveal unexpected relationships that may be assayed using the ligands themselves...
  10. pmc Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
    Omid C Farokhzad
    Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6315-20. 2006
    ..Dtxl alone had a survivability of only 14%. Saline and nanoparticles without drug were similarly nonefficacious. This report demonstrates the potential utility of nanoparticle-aptamer bioconjugates for a therapeutic application...
  11. ncbi Strategies in the design of nanoparticles for therapeutic applications
    Robby A Petros
    Department of Chemistry, University of North Texas, Denton, Texas 76203, USA
    Nat Rev Drug Discov 9:615-27. 2010
    ..This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles...
  12. pmc Prediction of drug-target interaction networks from the integration of chemical and genomic spaces
    Yoshihiro Yamanishi
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Bioinformatics 24:i232-40. 2008
    ..Therefore, there is a strong incentive to develop new methods capable of detecting these potential drug-target interactions efficiently...
  13. ncbi Impact of nanotechnology on drug delivery
    Omid C Farokhzad
    Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    ACS Nano 3:16-20. 2009
    ..Herein, we focus on the application of nanotechnology to drug delivery and highlight several areas of opportunity where current and emerging nanotechnologies could enable entirely novel classes of therapeutics...
  14. pmc Drug delivery and nanoparticles:applications and hazards
    Wim H De Jong
    Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Int J Nanomedicine 3:133-49. 2008
    ..So, probably additional more specific testing would be needed...
  15. ncbi Biodegradable polymeric nanoparticles as drug delivery devices
    K S Soppimath
    Department of Chemistry, Polymer Research Group, Karnatak University, Dharwad 580 003, India
    J Control Release 70:1-20. 2001
    ..presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems. Methods of preparation, drug loading and drug release are covered...
  16. ncbi In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
    Ximei Qian
    Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    Nat Biotechnol 26:83-90. 2008
    ....
  17. pmc Targeting of drugs and nanoparticles to tumors
    Erkki Ruoslahti
    Vascular Mapping Center, Sanford Burnham Medical Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    J Cell Biol 188:759-68. 2010
    ..We review the recent advances in this delivery approach with a focus on the use of molecular markers of tumor vasculature as the primary target and nanoparticles as the delivery vehicle...
  18. ncbi Immunological properties of engineered nanomaterials
    Marina A Dobrovolskaia
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, NCI Frederick, 1050 Boyles St, Bldg 469, Frederick, Maryland 21702, USA
    Nat Nanotechnol 2:469-78. 2007
    ..Modifying these factors can significantly reduce the immunotoxicity of nanoparticles and make them useful platforms for drug delivery...
  19. ncbi Chitosan-based drug delivery systems
    Andreas Bernkop-Schnürch
    Department of Pharmaceutical Technology, University of Innsbruck, Innsbruck, Austria
    Eur J Pharm Biopharm 81:463-9. 2012
    ..the past 20 years, a considerable amount of work has been published on chitosan and its potential use in drug delivery systems. In contrast to all other polysaccharides having a monograph in a pharmacopeia, chitosan has a cationic ..
  20. pmc Nanotechnology in drug delivery and tissue engineering: from discovery to applications
    Jinjun Shi
    MIT Harvard Center for Cancer Nanotechnology Excellence, Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nano Lett 10:3223-30. 2010
    ....
  21. ncbi PEGylation, successful approach to drug delivery
    Francesco M Veronese
    Department of Pharmaceutical Sciences, Padua University, Italy
    Drug Discov Today 10:1451-8. 2005
    ..Thanks to these favorable properties, PEGylation now plays an important role in drug delivery, enhancing the potentials of peptides and proteins as therapeutic agents...
  22. pmc The blood-brain barrier: bottleneck in brain drug development
    William M Pardridge
    Department of Medicine, UCLA, Los Angeles, California 90024, USA
    NeuroRx 2:3-14. 2005
    ..This provides the platform for CNS drug delivery programs, which should be developed in parallel with traditional CNS drug discovery efforts in the molecular neurosciences...
  23. ncbi Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
    H Maeda
    Laboratory of Microbiology and Oncology, Sojo University, Kumamoto, Japan
    Eur J Pharm Biopharm 71:409-19. 2009
    ....
  24. ncbi Nanoparticle and targeted systems for cancer therapy
    Lisa Brannon-Peppas
    Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712 0231, USA
    Adv Drug Deliv Rev 56:1649-59. 2004
    ..Delivery methods that specifically use nanoparticles are also highlighted, including both degradable and nondegradable polymers...
  25. pmc SuperTarget and Matador: resources for exploring drug-target relationships
    Stefan Günther
    Structural Bioinformatics Group, Institute of Molecular Biology and Bioinformatics, Charite University Medicine Berlin, Arnimallee 22, 14195 Berlin, Germany
    Nucleic Acids Res 36:D919-22. 2008
    ..SuperTarget and Matador are available at http://insilico.charite.de/supertarget and http://matador.embl.de...
  26. ncbi The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices
    R A Jain
    NanoSystems, a Division of Elan Pharmaceutical Technologies, King of Prussia, PA 19406, USA
    Biomaterials 21:2475-90. 2000
    ..Also, certain issues about other related biodegradable polyesters are discussed...
  27. pmc Current advances in research and clinical applications of PLGA-based nanotechnology
    Jian ming Lu
    Michael E DeBakey Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Expert Rev Mol Diagn 9:325-41. 2009
    ....
  28. ncbi Glycyrrhetinic acid-modified poly(ethylene glycol)-b-poly(gamma-benzyl l-glutamate) micelles for liver targeting therapy
    Wei Huang
    Institute of Polymer Chemistry, Nankai University, Tianjin, People s Republic of China
    Acta Biomater 6:3927-35. 2010
    ..The cytotoxicity of DOX/GA-PEG-PBLG micelles (IC(50) 47 ngml(-1)) was much higher than that of free DOX (IC(50) 90 ngml(-1)). These results indicate that GA-modified micelles have great potential in liver targeting therapy...
  29. ncbi Exploiting the enhanced permeability and retention effect for tumor targeting
    Arun K Iyer
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 862 0082, Japan
    Drug Discov Today 11:812-8. 2006
    ..Some innovative examples developed by researchers to combat cancer by the EPR mechanism are also discussed...
  30. ncbi Biodegradable polymeric nanoparticles based drug delivery systems
    Avnesh Kumari
    Biotechnology Division, Institute of Himalayan Bioresource Technology, CSIR, Palampur, HP 176061, India
    Colloids Surf B Biointerfaces 75:1-18. 2010
    ..We have highlighted the impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates...
  31. pmc Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
    Derek W Bartlett
    Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210 41, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:15549-54. 2007
    ..Optimization of internalization may therefore be key for the development of effective nanoparticle-based targeted therapeutics...
  32. ncbi Gold nanoparticles in delivery applications
    Partha Ghosh
    Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA
    Adv Drug Deliv Rev 60:1307-15. 2008
    ..An additional attractive feature of AuNPs is their interaction with thiols, providing an effective and selective means of controlled intracellular release...
  33. ncbi Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems
    Oktay Tacar
    School of Biomedical and Health Sciences, Victoria University, St Albans, Australia
    J Pharm Pharmacol 65:157-70. 2013
    ..While providing a cure in select cases, doxorubicin causes toxicity to most major organs, especially life-threatening cardiotoxicity, which forces the treatment to become dose-limiting...
  34. pmc Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
    Samuel K Lai
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 104:1482-7. 2007
    ....
  35. ncbi Electrospun matrices for localized drug delivery: current technologies and selected biomedical applications
    Anne J Meinel
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    Eur J Pharm Biopharm 81:1-13. 2012
    ..of post-spinning modification techniques add to the large repertoire and enable development of tailored drug delivery systems. Herein we provide an overview on current developments regarding different techniques to manufacture ..
  36. pmc Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions
    Natalya Rapoport
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 153:4-15. 2011
    ..Anticipated mechanisms of the observed effects are discussed...
  37. ncbi Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
    Norased Nasongkla
    Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nano Lett 6:2427-30. 2006
    ..In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles...
  38. ncbi Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery
    Katarzyna Migalska
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Pharm Res 28:1919-30. 2011
    ..To assess the feasibility of transdermal macromolecule delivery using novel laser-engineered dissolving microneedles (MNs) prepared from aqueous blends of 20% w/w poly(methylvinylether maleic anhydride) (PMVE/MA) in vitro and in vivo...
  39. ncbi Applications of carbon nanotubes in drug delivery
    Alberto Bianco
    Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
    Curr Opin Chem Biol 9:674-9. 2005
    The development of new and efficient drug delivery systems is of fundamental importance to improve the pharmacological profiles of many classes of therapeutic molecules...
  40. pmc Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems
    Josias H Hamman
    Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa
    Mar Drugs 8:1305-22. 2010
    ..Furthermore, recent investigations into the use of these complexes as excipients in drug delivery systems such as nano- and microparticles, beads, fibers, sponges and matrix type tablets are briefly described.
  41. pmc "SMART" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers
    R M Sawant
    Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, USA
    Bioconjug Chem 17:943-9. 2006
    ..We consider this result as the first step in the development of multifunctional stimuli-sensitive pharmaceutical nanocarriers...
  42. ncbi Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery
    Giulio F Paciotti
    CytImmune Sciences, Inc, College Park, Maryland 20740, USA
    Drug Deliv 11:169-83. 2004
    ..Finally, PT-cAu-TNF was less toxic and more effective in reducing tumor burden than native TNF since maximal antitumor responses were achieved at lower doses of drug...
  43. pmc Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device
    Shanta Dhar
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 130:11467-76. 2008
    ....
  44. ncbi Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting
    Khaled Greish
    Department of Pharmaceuticals and Pharmaceutical Chemistry, and Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA
    Methods Mol Biol 624:25-37. 2010
    ..Indeed, this selective high local concentration of nano-sized anticancer drugs in tumor tissues has proven superior in therapeutic effect with minimal side effects in both preclinical and clinical settings...
  45. ncbi Inhaled nanoparticles--a current review
    Wei Yang
    College of Pharmacy, University of Texas at Austin, TX 78712 1074, USA
    Int J Pharm 356:239-47. 2008
    ..The potential application of pulmonary drug delivery of nanoparticles to the lungs, specifically in context of published results reported on nanomaterials in environmental epidemiology and toxicology is reviewed in this paper...
  46. ncbi Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery
    Katherine Ferrara
    Department of Biomedical Engineering, University of California, Davis, California 95616 8686, USA
    Annu Rev Biomed Eng 9:415-47. 2007
    ..The technology, early successes with drug and gene delivery, and potential clinical applications are reviewed...
  47. ncbi Application of nanotechnology in cancer therapy and imaging
    Xu Wang
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    CA Cancer J Clin 58:97-110. 2008
    ..Therefore, their application as cancer cell-specific delivery vehicles will be a significant addition to the currently available armory for cancer therapeutics and imaging...
  48. ncbi PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect
    Sarbari Acharya
    Institute of Life Sciences, Nalco Square, Bhubaneswar, India
    Adv Drug Deliv Rev 63:170-83. 2011
    ..Ongoing research about drug-loaded nanoparticles and their delivery by the EPR effect to the tumour tissues has been elucidated in this review with clarity...
  49. ncbi Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound
    Lisa H Treat
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 121:901-7. 2007
    ..Our technique using MRI-guided focused ultrasound to achieve therapeutic levels of DOX in the brain offers a large step forward in the use of chemotherapy to treat patients with CNS malignancies...
  50. ncbi Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
    Ralph Weissleder
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Bldg 149, 13th Street, Room 5403, Charlestown, Massachusetts 02129, USA
    Nat Biotechnol 23:1418-23. 2005
    ..The method and described materials could facilitate development of functional nanomaterials for applications such as differentiating cell lines, detecting distinct cellular states and targeting specific cell types...
  51. ncbi Superparamagnetic iron oxide nanoparticle probes for molecular imaging
    Daniel L J Thorek
    Cellular and Molecular Imaging Group, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Ann Biomed Eng 34:23-38. 2006
    ..In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch...
  52. ncbi Biodegradation, biodistribution and toxicity of chitosan
    T Kean
    Case Western Reserve University, Orthopaedics Department, Cleveland, Ohio 44106, USA
    Adv Drug Deliv Rev 62:3-11. 2010
    ..Here we aim to review research in this area and critically discuss chitosan's potential to be used as a generally regarded as safe (GRAS) material...
  53. pmc Recent advances of chitosan nanoparticles as drug carriers
    Jun Jie Wang
    Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou, Zhejiang, People s Republic of China
    Int J Nanomedicine 6:765-74. 2011
    ..This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications...
  54. ncbi Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78
    Yasufumi Katanasaka
    Department of Medical Biochemistry, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Int J Cancer 127:2685-98. 2010
    ..cells, especially on the plasma membrane, may be molecular targets for antiangiogenic drugs and drug delivery systems (DDS) in cancer therapy...
  55. ncbi Improving the cardio protective effect of aFGF in ischemic myocardium with ultrasound-mediated cavitation of heparin modified microbubbles: preliminary experiment
    Ying Zheng Zhao
    Wenzhou Medical College, Wenzhou City, Zhejiang Province, China
    J Drug Target 20:623-31. 2012
    ..With the visual imaging and US-triggered drug release advantages, US-mediated cavitation of aFGF-HMB might be developed as a novel technique for targeting delivery of aFGF into ischemic myocardium...
  56. pmc A new era of cancer treatment: carbon nanotubes as drug delivery tools
    Seyed Yazdan Madani
    Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Sciences, University College London, UK
    Int J Nanomedicine 6:2963-79. 2011
    ..Hence, in this review, we seek to explore the biomedical applications of CNTs, with particular emphasis on their use as therapeutic platforms in oncology...
  57. ncbi Recent perspectives in ocular drug delivery
    Ripal Gaudana
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110 2499, USA
    Pharm Res 26:1197-216. 2009
    ..In this review, we have briefly discussed several ocular drug delivery systems such as microemulsions, nanosuspensions, nanoparticles, liposomes, niosomes, dendrimers, implants, and ..
  58. pmc Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK
    Pharm Res 28:41-57. 2011
    ..The aim of this study was to optimise polymeric composition and assess the performance of microneedle devices that possess different geometries...
  59. ncbi Antibody-drug conjugates: targeted drug delivery for cancer
    Stephen C Alley
    Seattle Genetics, Inc, 21823 30th Drive SE, Bothell, WA 98021, United States
    Curr Opin Chem Biol 14:529-37. 2010
    ..This review highlights the recent pre-clinical and clinical advances that have been made...
  60. pmc Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles
    Chung Hang J Choi
    Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 107:1235-40. 2010
    ..These results suggest that targeted nanoparticles can provide greater intracellular delivery of therapeutic agents to the cancer cells within solid tumors than their nontargeted analogs...
  61. pmc Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles
    Shanta Dhar
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:17356-61. 2008
    ..The effectiveness of PSMA targeted Pt-NP-Apt nanoparticles against the PSMA(+) LNCaP cells is approximately an order of magnitude greater than that of free cisplatin...
  62. pmc Thioaptamer conjugated liposomes for tumor vasculature targeting
    Aman P Mann
    Department of Nanomedicine, University of Texas Health Science Center at Houston, 1825 Hermann Pressler, Houston, Texas 77030, USA
    Oncotarget 2:298-304. 2011
    ....
  63. ncbi Nanocarriers' entry into the cell: relevance to drug delivery
    Hervé Hillaireau
    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    Cell Mol Life Sci 66:2873-96. 2009
    ..Nevertheless, various strategies are being actively investigated in order to tailor nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes...
  64. ncbi Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
    Zhong Ming Qian
    Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong
    Pharmacol Rev 54:561-87. 2002
    ..Moreover, the OX26 monoclonal antibody against the rat transferrin receptor offers great promise in the delivery of therapeutic agents across the blood-brain barrier to the brain...
  65. ncbi Multifunctional nanocarriers
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA 02115, USA
    Adv Drug Deliv Rev 58:1532-55. 2006
    ....
  66. ncbi Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    C W Pouton
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Eur J Pharm Sci 11:S93-8. 2000
    ..The mechanisms of action and practical uses of each type of lipid formulation are discussed...
  67. pmc Ocular drug delivery
    Ripal Gaudana
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 2464 Charlotte St, Kansas City, Missouri 64108 2718, USA
    AAPS J 12:348-60. 2010
    ..Designing noninvasive sustained drug delivery systems and exploring the feasibility of topical application to deliver drugs to the posterior segment may ..
  68. ncbi Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
    L L Remsing Rix
    Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Leukemia 23:477-85. 2009
    ..Finally, bosutinib is the first kinase inhibitor shown to target CAMK2G, recently implicated in myeloid leukemia cell proliferation...
  69. pmc Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic
    Anu Puri
    Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
    Crit Rev Ther Drug Carrier Syst 26:523-80. 2009
    ..We conclude with a few examples of clinically successful formulations of currently available lipid-based nanoparticles...
  70. ncbi Chitosan as a novel nasal delivery system for vaccines
    L Illum
    West Pharmaceutical Services, Drug Delivery and Clinical Research Centre Ltd, Albert Einstein Centre, Nottingham Science and Technology Park, NG7 2TN, Nottingham, UK
    Adv Drug Deliv Rev 51:81-96. 2001
    ..The results of the study showed that the nasal chitosan influenza vaccine was both effective and protective according to the CPMP requirements. The mechanism of action of the chitosan nasal vaccine delivery system is also discussed...
  71. pmc Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    Stereotact Funct Neurosurg 89:141-51. 2011
    ..The targeting accuracy of this delivery system and the performance of the infusion cannula were validated in nonhuman primates...
  72. ncbi Protein transduction technology
    Jehangir S Wadia
    Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0686, USA
    Curr Opin Biotechnol 13:52-6. 2002
    ....
  73. ncbi Subcellular targeting strategies for drug design and delivery
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Rev Drug Discov 9:29-42. 2010
    ..In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery...
  74. pmc Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
    Omid Veiseh
    Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195 2120, USA
    Adv Drug Deliv Rev 62:284-304. 2010
    ..A careful review of the chemistries used to modify the surfaces of MNPs is also given, with attention paid to optimizing the activity of bound ligands while maintaining favorable physicochemical properties...
  75. ncbi Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells
    Shirzad Azarmi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 9:124-32. 2006
    ....
  76. pmc DrugBank: a comprehensive resource for in silico drug discovery and exploration
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 34:D668-72. 2006
    ..DrugBank is available at http://redpoll.pharmacy.ualberta.ca/drugbank/...
  77. ncbi Nanoparticles for drug delivery in cancer treatment
    Barbara Haley
    Department of Medicine, Division of Hematology Oncology, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Urol Oncol 26:57-64. 2008
    ..This new technology provides many exciting therapeutic approaches for targeted high concentration drug delivery to cancer cells with reduced injury of normal cells...
  78. ncbi Active targeting schemes for nanoparticle systems in cancer therapeutics
    James D Byrne
    Department of Biomedical Engineering, The University of Texas at Austin, TX 78738, USA
    Adv Drug Deliv Rev 60:1615-26. 2008
    ..The targeting schemes explored for many of the reported nanoparticle systems suggest the great potential of targeted delivery to revolutionize cancer treatment...
  79. ncbi Fluorescence nanoparticles "quantum dots" as drug delivery system and their toxicity: a review
    Shirin Ghaderi
    Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, UK
    J Drug Target 19:475-86. 2011
    ..This review will look at cadmium-derived QDs and discuss their future and their possible toxicities in a disease situation...
  80. pmc Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 34:834-40. 2008
    ..It also suggests that lower frequency sonication produces less red blood cell extravasation per unit area...
  81. ncbi Effect of controlled laser microporation on drug transport kinetics into and across the skin
    Y G Bachhav
    School of Pharmaceutical Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    J Control Release 146:31-6. 2010
    ..L.E.A.S.E.(R) (i) to create well-defined conduits in the skin, (ii) to provide a controlled enhancement of transdermal transport and (iii) to enable improvement in both the rate and extent of drug delivery...
  82. ncbi Using laser microporation to improve transdermal delivery of diclofenac: Increasing bioavailability and the range of therapeutic applications
    Yogeshwar G Bachhav
    School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland
    Eur J Pharm Biopharm 78:408-14. 2011
    ..A similar improvement in topical diclofenac delivery in vivo may increase the number of potential therapeutic applications...
  83. pmc Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: what should be the policy?
    Babak Kateb
    Brain Mapping Foundation, West Hollywood, CA 90046, USA
    Neuroimage 54:S106-24. 2011
    ....
  84. ncbi Reversible blood-brain barrier disruption by repeated transcranial focused ultrasound allows enhanced extravasation
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    J Control Release 150:111-6. 2011
    ..This noninvasive technology offers the possibility of controlling the extent of drug delivery by means of repeated treatment and adjusting the duration and interval between sonications...
  85. pmc Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction
    Nadine Wong Shi Kam
    Department of Chemistry and Laboratory for Advanced Materials, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:11600-5. 2005
    ..Thus, the transporting capabilities of carbon nanotubes combined with suitable functionalization chemistry and their intrinsic optical properties can lead to new classes of novel nanomaterials for drug delivery and cancer therapy...
  86. pmc Microbubbles in ultrasound-triggered drug and gene delivery
    Sophie Hernot
    Cardiovascular Division, Department of Medicine, University of Virginia School of Medicine, P O Box 800158, RM1026, Hospital Drive, Cobb Hall, Charlottesville, VA 22908 0158, USA
    Adv Drug Deliv Rev 60:1153-66. 2008
    ..Accelerated blood clot dissolution in the areas of insonation by cooperative action of thrombolytic agents and microbubbles is demonstrated in several clinical trials...
  87. ncbi Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications
    Ajay Kumar Gupta
    Laboratory for Nanoparticle Research, Formulation and Development Department, Torrent Research Centre, TPL, Village Bhat, Dist Gandhinagar 382 428, Gujarat, India
    Nanomedicine (Lond) 2:23-39. 2007
    ..We have reviewed the various biomedical applications with some of the most recent uses of magnetic nanoparticles for early detection of cancer, diabetes and atherosclerosis...
  88. ncbi Microneedles for transdermal drug delivery
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Adv Drug Deliv Rev 56:581-7. 2004
    ..Together, these results suggest that microneedles represent a promising technology to deliver therapeutic compounds into the skin for a range of possible applications...
  89. ncbi Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs
    Bok Ki Kang
    Department of Polymer Science and Engineering, Chonbuk National University, Duckjin Dong, Jeonju 561 756, South Korea
    Int J Pharm 274:65-73. 2004
    ..5-fold increase in bioavailability compared with the conventional tablet. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds, such as simvastatin by the oral route...
  90. ncbi Blood-brain barrier drug targeting: the future of brain drug development
    William M Pardridge
    Department of Medicine UCLA School of Medicine Los Angeles, CA 90024, USA
    Mol Interv 3:90-105, 51. 2003
    ..Pardridge reviews the functions of the various known transport systems in the brain and discusses how the development of BBB drug-targeting programs in pharmaceutical and academic settings may lead to more efficacious treatments...
  91. ncbi Delivery of peptides and proteins through the blood-brain barrier
    U Bickel
    Department of Medicine, UCLA School of Medicine, Research Laboratory, Los Angeles, CA 90095 1682, USA
    Adv Drug Deliv Rev 46:247-79. 2001
    ....
  92. ncbi Nanoparticles in photodynamic therapy: an emerging paradigm
    Dev Kumar Chatterjee
    Division of Bioengineering, National University of Singapore, 117574, Singapore
    Adv Drug Deliv Rev 60:1627-37. 2008
    ..Although several challenges remain before they can be adopted for clinical use, these active or second-generation PDT nanoparticles probably offer the best hope for extending the reach of PDT to regions deep in the body...
  93. ncbi Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach
    Anne des Rieux
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, avenue E Mounier, 73 20, 1200 Brussels, Belgium
    J Control Release 116:1-27. 2006
    ..Encouraging results upon in vivo testing are reported but low bioavailability and lack of control on absorbed dose slow down products development. Vaccines are certainly the most promising applications for orally delivered nanoparticles...
  94. ncbi Iron oxide nanoparticles for sustained delivery of anticancer agents
    Tapan K Jain
    Department of Pharmaceutical Sciences, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska 68198 6025, USA
    Mol Pharm 2:194-205. 2005
    ..This nanoparticle formulation can be used as a universal drug carrier system for systemic administration of water-insoluble drugs while simultaneously allowing magnetic targeting and/or imaging...
  95. pmc Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
    Jianjun Cheng
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biomaterials 28:869-76. 2007
    ..22%+/-0.07% of injected dose per gram of tissue; mean+/-SD, n=4, p=0.002). The ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies...
  96. ncbi Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer
    Yogeshkumar Malam
    Centre for Nanotechnology, Biomaterials and Tissue Engineering, University College London, London, UK
    Trends Pharmacol Sci 30:592-9. 2009
    Nanoscale drug delivery systems using liposomes and nanoparticles are emerging technologies for the rational delivery of chemotherapeutic drugs in the treatment of cancer...
  97. pmc Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery
    Monty Liong
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    ACS Nano 2:889-96. 2008
    ..The highly versatile multifunctional nanoparticles could potentially be used for simultaneous imaging and therapeutic applications...
  98. ncbi Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines
    Khaled Greish
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    J Drug Target 15:457-64. 2007
    ..In this review the mechanisms and factors involved in the EPR effect, as well as the uniqueness of nanoscale drugs for tumor targeting through EPR effect, will be discussed in detail...
  99. pmc Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery
    Ashwin A Bhirde
    Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
    ACS Nano 3:307-16. 2009
    ..Most significantly, regression of tumor growth was rapid in mice treated with targeted SWNT-cisplatin-EGF relative to nontargeted SWNT-cisplatin...
  100. ncbi Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI
    E Kleemann
    Department of Pharmaceutics and Biopharmacy, Philipps University, Marburg, Germany
    J Control Release 109:299-316. 2005
    ..Thus, TAT-PEG-PEI represents a new approach to non-viral gene carriers for lung therapy, comprising protection for plasmid DNA, low toxicity and significantly enhanced transfection efficiency under in vivo conditions...
  101. ncbi Drug targeting to the brain
    William M Pardridge
    Department of Medicine, UCLA, Warren Hall 13 164 900 Veteran Ave, Los Angeles, CA 90024, USA
    Pharm Res 24:1733-44. 2007
    ..Molecular Trojan horses may be formulated with fusion protein technology, avidin-biotin technology, or Trojan horse liposomes to target to brain virtually any large molecule pharmaceutical...

Research Grants78

  1. Antifungal Denture Adhesive Film for Oral Candidiasis
    THOMAS GERDING; Fiscal Year: 2004
    ..Aim 5 will evaluate and finalize two optimal bioadhesive drug delivery systems for each model antifungal drug...
  2. Tumor drug delivery systems based on polymalic acid
    Julia Y Ljubimova; Fiscal Year: 2010
    ..Aim 4. Evaluation of the effects of lead compounds on animal survival, tumor size, vascularity, apoptosis, and expression of their molecular targets, EGFR and laminin-8, in xenotransplanted human tumors. ..
  3. Suppression of Ocular Scarring - Controlled Delivery of an ALK-5 Inhibitor
    Hiroshi Nakamura; Fiscal Year: 2013
    ..Recently, controlled drug delivery systems using gel as a depot have been developed, which allow for easier administration and reduced irritation/..
  4. Depot calcineurin inhibitors to prevent graft rejection
    Thomas J Smith; Fiscal Year: 2010
    ..The PI led the team that developed two other FDA approved drug delivery systems. More than 50,000 transplants requiring immunosupression are performed annually in the largest 7 markets (..
  5. Nanodiagnostics and Nanotherapeutics: Building Research Ethics and Oversight
    Susan M Wolf; Fiscal Year: 2010
    ..to develop nanoscale tools for in vitro diagnostics, in vivo imaging agents, drugs and therapies, targeted drug delivery systems, nanoparticle and other nanoscale gene delivery vectors, biomaterials for enhanced tissue engineering, and ..
  6. Tumor -Targeting Chemotherapeutic Agents
    Iwao Ojima; Fiscal Year: 2013
    ..Therefore, the development of new and efficient tumor-specific drug delivery systems with potent anticancer agents is an urgent need in the 21st century chemotherapy to dramatically enhance ..
  7. Rigid-rod Peptides as Nanocarriers for Delivery of Cancer Drugs
    Katarzyna Slowinska; Fiscal Year: 2013
    ..The goal of this proposal is to develop a novel class of local drug delivery systems (nanocarriers) for low solubility drugs (such as PTX) based on collagen mimetic peptides assembled into ..
  8. Leica LMD 7000 Laser Capture Microdissection Microscope
    Siegfried Janz; Fiscal Year: 2013
    ..of human cystic fibrosis;Maureen Donovan studies transporter proteins in the nasal mucosa for improved drug delivery systems to the brain;and David Soll evaluates factors of pathogenicity in the yeast, Candida albicans, the ..
  9. Biodegradable Polymeric Nanosphere Drug Delivery System For Cancer Chemotherapy
    Emmanuel O Akala; Fiscal Year: 2010
    ..the biophase (site of action), identification of potential targets and targeting moieties for anti-cancer drug delivery systems, drug combination, and the development of efficient drug carriers...
  10. Gated Carbon Nanotube Membrane Transdermal Drug Delivery
    BRUCE JACKSON HINDS; Fiscal Year: 2013
    ..An electrically gated membrane could have broad applications in numerous drug delivery systems with production costs for membranes anticipated to be about $0.20/sq.ft...
  11. A NOVEL METHOD TO TREAT CHRONIC PAIN
    SATHYANARAYANA N MURTHY; Fiscal Year: 2013
    ..In addition, there is need to develop drug delivery systems which can sustain the retention of drug in CSF to prolong its pharmacological activity...
  12. Glutaminase: neurotoxic link in HIV-1 Associated Dementia
    JIALIN CHARLES ZHENG; Fiscal Year: 2013
    ..neuronal injury during HIV-1 infection will aid in developing potential new therapeutic agents and drug delivery systems for the treatment of HAD. PUBLIC HEALTH RELEVANCE: Globally, about 40 million people are infected with HIV...
  13. BONE TARGETED DELIVERY OF ANABOLIC AGENTS
    JINDRICH H KOPECEK; Fiscal Year: 2011
    ..The advantages of the proposed drug delivery systems are: selective adsorption to the tissues in bone with higher rates of bone turnover, localization of the ..
  14. Synthetic Cell Surface Receptors for Anticancer Drug Delivery
    Blake Peterson; Fiscal Year: 2012
    ..We further propose to construct the first anticancer drug delivery systems designed to cross membrane barriers by accessing a defined membrane trafficking pathway...
  15. MOLECULAR AND CELLULAR TRANSPORT IN MUCUS
    W Mark Saltzman; Fiscal Year: 2012
    ..to quantify the barriers to nanoparticle transport at these tissue sites, and to develop polymeric drug delivery systems that overcome the barriers...
  16. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir P Torchilin; Fiscal Year: 2012
    ..We aim to engineer a platform for creating drug delivery systems capable of intracellular penetration and specific targeting of intracellular compartments and organelles, ..
  17. Targeted Polymer Micelles for Treatment of Metastatic Melanoma
    Kevin N Sill; Fiscal Year: 2013
    ..e. change in the pH level. Furthermore, drug delivery systems that employ active targeting strategies will gain an additional advantage in the ability to target tumor ..
  18. Methods & Noninvasive PK Study to Improve Iontophoresis
    S Kevin Li; Fiscal Year: 2010
    ..provide a knowledge base that allows pharmaceutical scientists to improve ocular iontophoresis and other drug delivery systems. It will be a great benefit to the public if an effective drug delivery system such as ocular ..
  19. Sustained Release Inner Ear Delivery of Corticosteroid
    William H Slattery; Fiscal Year: 2011
    ..of this research program is to reduce or eliminate deafness by developing sustained release intracochlear drug delivery systems. The goal of this project is to develop a steroid eluting cochlear implant...
  20. Effective Delivery of Pharmaceutical Aerosols during Non-Invasive Ventilation
    P Worth Longest; Fiscal Year: 2012
    ..The objective of this study is to develop aerosol drug delivery systems that can significantly improve pulmonary drug deposition during NIV using a condensational growth approach...
  21. Using Molecular Modeling to Determine Structure and Organization in Skin Lipids
    Clare McCabe; Fiscal Year: 2012
    ..clarify the role of abnormal lipid composition in the symptoms of diseased skin, aid development of treatments for restoring barrier function, and provide insights needed for the rational design of transdermal drug delivery systems.
  22. Transscleral Drug Delivery for Retinal Disorders
    HENRY FRANCIS EDELHAUSER; Fiscal Year: 2010
    ..b>Drug delivery systems are established in vitro already, and during the first year will produce data sets for model refinement ..
  23. Multifunctional Nanotherapeutics for Cancer Treatment and Imaging
    Tamara Minko; Fiscal Year: 2013
    ..is to verify the hypothesis and develop a mixture (cocktail) of novel multifunctional Nanotechnology-based Drug Delivery Systems (NDDS) that will significantly increase the efficacy of the chemotherapy of primary ovarian cancer and ..
  24. Maldi/ToF/ToF Mass Spectrometer for the University of Utah
    Chad C Nelson; Fiscal Year: 2010
    ..Maldi/ToF/ToF instrument are wide and diverse, including topics such as polymer investigations for drug delivery systems, intact receptor proteins, development of fluorogenic peptide probes, discovery of novel neuropeptides ..
  25. Alternative Formulations of Tenofovir and UC781
    Lisa C Rohan; Fiscal Year: 2013
    ..Polymeric film drug delivery systems for intra-vaginal application will be developed for these reverse transcriptase inhibitors...
  26. Role of cerebrospinal fluid dynamics in brain drug delivery
    JAY CHRISTOPHER SY; Fiscal Year: 2013
    ..b>Drug delivery systems have been used to ferry drugs to the brain and central nervous system (CNS), however cerebrospinal fluid (..
  27. PREVENTION OF HEMODIALYSIS VASCULAR ACCESS STENOSIS
    Alfred K Cheung; Fiscal Year: 2010
    ..This is a competitive renewal resubmission for a project to develop novel sustained drug delivery systems that could be injected percutaneously and allow local delivery of anti-proliferative drugs to prevent ..
  28. Chemical Methods for Ferrous Iron Targeted Drug Delivery
    ADAM ROBERT RENSLO; Fiscal Year: 2012
    ..falciparum parasites. The goals of the proposed research are to evaluate iron(II)-targeted drug delivery systems in animals, and to optimize the existing delivery chemistry for reduced complexity and more rapid drug ..
  29. sc-rAAV8 via Lumbar Puncture as Spinal Analgesic Drug Delivery Systems
    Andreas S Beutler; Fiscal Year: 2013
    ..abstract_text> ..
  30. Porous Silicon Particles for Sustained Intravitreal Drug Delivery
    Lingyun Cheng; Fiscal Year: 2013
    ..It is expected that the proposed Psi based ocular drug delivery systems will alleviate the need for frequent intravitreal injections or intraocular surgery for drug device ..
  31. Bright and Fast Sensor for Time Resolved X-Ray Diffraction Studies
    VIVEK V NAGARKAR; Fiscal Year: 2010
    ..the important "protein folding problem" and the study of phase transitions in model membrane systems, the understanding of which is vital for many biotechnological applications, such as the design of various drug delivery systems.
  32. Tumor-targeting Salmonella expressing apoptosis-inducing cytotoxic proteins
    DAVID G BERMUDES; Fiscal Year: 2013
    ..provided by applicant): Tumor-targeting bacteria offer a number of advantages over other cancer drug delivery systems, including targeting of multiple tumors from a distant inoculation site, selective intratumoral ..
  33. Heat Effect on Generic Transdermal Drug Delivery Systems
    Audra L Stinchcomb; Fiscal Year: 2013
    ABSTRACT Drug release from different transdermal drug delivery systems (TDDS) is governed by a number of factors including: skin condition, occlusion, exposure to heat, different inactive ingredients, sweat, age and patch design (..
  34. The 3D whole Body Distribution of NIR transferrin using FRET tomography imaging
    Margarida Barroso; Fiscal Year: 2012
    ..Moreover, transferrin has been widely used as carrier for anti-cancer drug delivery systems since the transferrin-receptor is upregulated in tumors...
  35. Mussel-inspired self-healing hydrogels for vascular tissue repair
    DOMINIC EDWARD FULLENKAMP; Fiscal Year: 2012
    ..We propose to develop materials that have the ability to self-heal, which are inspired by the mussel byssal thread, and may prove to be good tissue replacements for small vessels. ..
  36. A Drug Delivery Platform For Near-Term Treatment of Proteolytic Disease
    JEFFREY MICHAEL KARP; Fiscal Year: 2013
    ..Additionally, conventional polymeric drug delivery systems such as implants, injectable microspheres, and patches are used by tens of millions of people annually, ..
  37. DOUBLE-TARGETED MACROMOLECULAR THERAPEUTICS FOR THE TREATMENT OF PROSTATE CANCER
    JINDRICH H KOPECEK; Fiscal Year: 2012
    ..double-targeted macromolecular therapeutics provides a new paradigm for the design of efficient anticancer drug delivery systems for the treatment of prostate cancer...
  38. Pediatric Pharmacology Research Unit Network
    Edmund Capparelli; Fiscal Year: 2009
    ..and physiologic based pharmacokinetics);d) Use of new molecular approaches;e)Applications of new drug delivery systems to pediatric therapy. 4...
  39. Nanoporous Drug Delivery Systems
    Sergei N Smirnov; Fiscal Year: 2013
    ....
  40. Pilot--Central Synaptic Function in Diabetic Rat
    VALERIE HAFTEL; Fiscal Year: 2009
    ..neurons involved in locomotor dysfunction in diabetes, and aid in directing effective therapeutic regimens using novel drug delivery systems with an appropriate time course when treatment is likely to be more effective.
  41. Rechargeable Infection-responsive Anticandidal Denture Materials
    Chih ko Yeh; Fiscal Year: 2013
    ..Furthermore, this new technology could be potentially used in a broad range of drug delivery systems for other oral or systemic diseases and/or infection control of dental/medical devices.
  42. Novel Magneto-Electric Nanodelivery of Drugs to Eradicate HIV from CNS
    Madhavan P Nair; Fiscal Year: 2013
    ..In recent years, use of nanotechnology in medicine has shown exciting prospect for development of novel drug delivery systems. However, the existing technologies suffer from the lack of adequate transendothelial penetration before ..
  43. Targeted therapy in Type 1 diabetes
    Anna Moore; Fiscal Year: 2013
    ..The discovery of novel targets, the development of efficient drug delivery systems and the integration of state-of-the-art imaging techniques will provide real-time monitoring of both drug ..
  44. Bioconjugation and self-assembly of carbon nanotubes
    David M Chenoweth; Fiscal Year: 2010
    ..have many potential applications some of which include substrates for cell growth or tissue regeneration, drug delivery systems, gene transfection reagents, nanotube (non-viral) mediated oligonucleotide transport for siRNA, and ..
  45. Intracellular delivery of proapoptotic peptide drugs for the treatment of cancer
    Patrick S Stayton; Fiscal Year: 2013
    ..This proposal will bring together the Stayton Lab's drug delivery systems with the Press'labs clinical cancer experience to develop preliminary animal validation of functional ..
  46. Sensitize Chemoresistant Breast Cancer by Nano-delivery of siRNA and Cisplatin
    Xiaoyang Xu; Fiscal Year: 2013
    ..blocks of the PLGA-PEG copolymer (PLGA and PEG) are widely used in FDA-approved implantable and injectable drug delivery systems and have a long history as safe, biodegradable materials, which are capable of encapsulating small- and ..
  47. Local delivery of minocycline to promote neuroprotection and recovery after SCI
    Yinghui Zhong; Fiscal Year: 2013
    ..However, current drug delivery systems are not ideal for local delivery of bioactive MH with sufficient dose and duration because MH is a small ..
  48. Childrens Mercy Hospital Fellowship Program in Pediatric Pharmacology
    GREGORY LEE KEARNS; Fiscal Year: 2013
    ..PK, PD, pharmacogenomics, bioinformatics, modeling/simulation, pharmacoepidemiology, treatment adherence, drug delivery systems, clinical trial design)...
  49. Dendritic Block Copolymer Micelles as New Targeted Drug Delivery Systems
    Paula T Hammond; Fiscal Year: 2010
    ..abstract_text> ..
  50. Universal Protein Carrier Scaffold for Small Molecules and Peptide Therapeutics
    DAVID IAN RABUKA; Fiscal Year: 2010
    ..As a result, there has been a large effort focused on the development of drug delivery systems, including using large biomolecules as carrier proteins...
  51. Biodegradable Field-Effect Transitors for Electronically Active Scaffolds
    CHRISTOPHER JOHN BETTINGER; Fiscal Year: 2010
    ..MEMS) have been utilized extensively in biomedical engineering including applications in biosensors and drug delivery systems. However, the lack of reportable electronic systems has limited the potential impact of MEMS for tissue ..
  52. RUTGERS-UMDNJ BIOTECHNOLOGY TRAINING PROGRAM
    Martin L Yarmush; Fiscal Year: 2013
    ..training has delivered numerous new drugs, diagnostics, and vaccines;new biomedical materials, devices and drug delivery systems;new crops that reduce pesticide use and industrial enzymes that cut chemical waste and energy consumption ..
  53. Evaluation of Dissolution Methods for Complex Parenteral Liposomal Formulations
    Paul M Bummer; Fiscal Year: 2013
    ..release methods has been hindered by lack of systematic, quantitative characterization of these complex drug delivery systems with respect to the myriad of factors that may contribute to drug release profiles, the wide range of ..
  54. Depot intra-articular fluticasone for the treatment of arthritis
    Thomas J Smith; Fiscal Year: 2013
    ..research is to reduce morbidity due to arthritis by developing long-lasting injectable intra-articular drug delivery systems. Intra-articular steroids have been a mainstay of treatment for arthritis for more than 50 years...
  55. Delivery of Polyphenols in Gum for Treatment of Gingivitis
    Craig Miller; Fiscal Year: 2009
    ..assembled a highly interdisciplinary team of investigators encompassing expertise in pharmaceutics, novel drug delivery systems for the oral cavity, periodontics, immunology, and oral medicine...
  56. In vivo regulation of bi-directional transport
    Steven P Gross; Fiscal Year: 2012
    ..Impaired vesicular transport is implicated in Neuronal degeneration. Finally, a better understanding of transport might allow the design of new drug delivery systems.
  57. Chemoprevention of pancreatic cancer using a combinatorial nano-drug system
    Sunil Prabhu; Fiscal Year: 2012
    ..Nanotechnology-based drug delivery systems are currently being evaluated to deliver chemopreventive combinations that would lower the doses with ..
  58. sPLA2 Selective Degradation of Nanoparticles
    BRIAN S contact CUMMINGS; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Studies proposed in this application will identify drug delivery systems that are selectively degraded in prostate tumors...
  59. Tumor-Homing Exosomes for Drug Delivery
    Michael W Graner; Fiscal Year: 2013
    ..Recent in vivo studies have reported that exosomes offer significant advantages over synthetic drug delivery systems including enhanced serum stability, low immunogenicity, and minimal clearance by lung, liver, and spleen...
  60. Targeted delivery of microRNA-loaded microvesicle for cancer therapy
    Thomas D Schmittgen; Fiscal Year: 2013
    ..This system does not rely upon the use of synthetic oligonucleotides or artificial drug delivery systems. Future manifestations of this technology can be applied to deliver other nucleic acid drugs such as shRNA ..
  61. Nanoparticle microbicides for delivery of combination antiretroviral drugs
    Kim A Woodrow; Fiscal Year: 2012
    ..This research plan is designed to evaluate nanoparticle-based vaginal drug delivery systems for HIV prevention...
  62. Nanoparticle microbicides for delivery of combination antiretroviral drugs
    Kim A Woodrow; Fiscal Year: 2013
    ..This research plan is designed to evaluate nanoparticle-based vaginal drug delivery systems for HIV prevention...
  63. High Capacity Nanocarriers for Cancer Chemotherapeutics
    Alexander V Kabanov; Fiscal Year: 2013
    ..toxicities, life-threatening side effects, and low water solubility of potentially highly-active drug candidates could result in the development of effective drug delivery systems that provide safety, bioavailability, and ease of use.
  64. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2001
    ..Currently, drug companies are attempting to develop subtype specific agonists as well as targeted drug delivery systems for sustained or regulated release of a drug...
  65. PEG PROMOTED MUCOADHESIVE DRUG DELIVERY SYSTEMS
    NIKOLAOS PEPPAS; Fiscal Year: 1999
    ..In the present work we develop, characterize and evaluate new drug delivery systems containing PEG...
  66. Asymmetric flow FFF and Composition Gradient/Light Scattering System
    Ewa Folta Stogniew; Fiscal Year: 2007
    ..control regions, nuclear pore complex, infection by group A streptococci, and the development of advanced drug delivery systems utilizing nano and microparticles...
  67. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 2003
    ..These include effective antibacterial dentifrices and mouthwashes, powered toothbrushes, local drug delivery systems and better systemic antimicrobial therapies...
  68. Aerosol Delivery of Lung Cancer Drugs
    Brian Hansen; Fiscal Year: 2002
    ..None of the currently available pulmonary drug delivery systems (CFC-propellant metered dose inhalers, aqueous solution nebulizers, and dry powder inhalers) are capable ..
  69. OCULAR CANNABINOID EFFECTS
    Gregory Liou; Fiscal Year: 2001
    ..Many new drug delivery systems have been developed since delta-9-tetrahydrocannabinol (THC) was tried topically in light mineral oil ..
  70. POLYMERIC PROTECTION OF IMPLANTABLE MICRO-ELECTRONICS
    Philip Troyk; Fiscal Year: 1990
    ..systems, cranial pressure monitors, blood ion and gas sensors, and implantable drug delivery systems for use with hypotension controlling drugs and insulin...
  71. 12TH ANNUAL INTERNATIONAL BIOMATERIALS SYMPOSIUM-1980
    Buddy Ratner; Fiscal Year: 1980
    ..surgery, orthopedics, cardiovascular surgery, blood behavior, opthalmologic materials, artifical organs, drug delivery systems, and safety and regulation of biomaterial devices...
  72. 12TH ANNUAL INTERNATIONAL BIOMATERIALS SYMPOSIUM-1980
    Buddy Ratner; Fiscal Year: 1980
    ..surgery, orthopaedics, cardiovascular surgery, blood behavior, opthalmologic materials, artificial organs, drug delivery systems, and safety and regulation of biomaterial devices...
  73. Phase II Construction of NCNPR Research Wing
    Larry A Walker; Fiscal Year: 2010
    ..funded research projects aimed at discovery, design, and synthesis of new drugs and development of new drug delivery systems for unmet therapeutic needs in human health, an important national priority...
  74. Carboxylated polysaccharides for drug delivery to the eye
    Wendy Townsend; Fiscal Year: 2006
    ..There is a need for improved topical ocular drug delivery systems from both a therapeutic and a marketing perspective...
  75. MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS
    Vladimir P Torchilin; Fiscal Year: 2010
    ..provided by applicant): The current level of engineering pharmaceutical nanocarriers allows for drug delivery systems (DOS) demonstrating a combination of several desired properties...
  76. Shape Specific, Enzyme-Responsive, Nano-Imprinted Particles for Drug Delivery
    Krishnendu Roy; Fiscal Year: 2009
    ..Although significant progress has been made in polymeric or liposomal drug delivery systems, there remain some key fundamental limitations...
  77. POLYMERS WITH BIOACTIVE DEGRADATION PRODUCTS
    Kathryn Uhrich; Fiscal Year: 2000
    Aromatic polyahydrides are clinically used as drug delivery systems for treatment of brain cancer...
  78. DELIVERY OF PROTEINS INTO CYTOSOL USING LLO-LIPOSOMES
    Kyung Dall Lee; Fiscal Year: 2002
    DESCRIPTION (Adapted from Investigator's Abstract): The cytosolic space of cells is an important target for drug delivery systems since many therapeutic agents are aimed at intervening or modifying specific molecular events occurring in ..