chemoprevention

Summary

Summary: The use of chemical compounds to prevent the development of a specific disease.

Top Publications

  1. ncbi Chemoprevention of cancer
    Anne S Tsao
    Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 54:150-80. 2004
  2. ncbi Cancer chemoprevention with dietary phytochemicals
    Young Joon Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Nat Rev Cancer 3:768-80. 2003
  3. ncbi Control of neglected tropical diseases
    Peter J Hotez
    Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 357:1018-27. 2007
  4. pmc Nrf2: friend or foe for chemoprevention?
    Thomas W Kensler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Carcinogenesis 31:90-9. 2010
  5. ncbi NFkappaB: a promising target for natural products in cancer chemoprevention
    Suaib Luqman
    College of Pharmacy, University of Hawaii, Hilo 96720, USA
    Phytother Res 24:949-63. 2010
  6. pmc Randomized, double-blind, placebo-controlled trial of monthly versus bimonthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria
    Khin Maung Lwin
    Shoklo Malaria Research Unit, Mae Sod, Thailand
    Antimicrob Agents Chemother 56:1571-7. 2012
  7. ncbi Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications
    Young Sam Keum
    Department of Biochemistry, College of Pharmacy, Dongguk University, 813 Siksa dong, Goyang, Kyunggi Do, 410 773, Republic of Korea
    Ann N Y Acad Sci 1229:184-9. 2011
  8. ncbi Cancer chemoprevention by targeting the epigenome
    Joseph Huang
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Curr Drug Targets 12:1925-56. 2011
  9. ncbi Oral preexposure anti-HIV prophylaxis for high-risk U.S. populations: current considerations in light of new findings
    Gavin M Myers
    Alpert Medical School of Brown University, Department of Community Health, Providence, Rhode Island, USA
    AIDS Patient Care STDS 25:63-71. 2011
  10. ncbi Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds
    R Sinha
    Division of Cancer Etiology and Prevention, American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Curr Cancer Drug Targets 4:13-28. 2004

Detail Information

Publications294 found, 100 shown here

  1. ncbi Chemoprevention of cancer
    Anne S Tsao
    Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 54:150-80. 2004
    Cancer chemoprevention is defined as the use of natural, synthetic, or biologic chemical agents to reverse, suppress, or prevent carcinogenic progression to invasive cancer...
  2. ncbi Cancer chemoprevention with dietary phytochemicals
    Young Joon Surh
    College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Nat Rev Cancer 3:768-80. 2003
    b>Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. Numerous phytochemicals derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process...
  3. ncbi Control of neglected tropical diseases
    Peter J Hotez
    Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 357:1018-27. 2007
  4. pmc Nrf2: friend or foe for chemoprevention?
    Thomas W Kensler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Carcinogenesis 31:90-9. 2010
    ..pathway can be induced by thiol-reactive small molecules that demonstrate protective efficacy in preclinical chemoprevention models and in clinical trials...
  5. ncbi NFkappaB: a promising target for natural products in cancer chemoprevention
    Suaib Luqman
    College of Pharmacy, University of Hawaii, Hilo 96720, USA
    Phytother Res 24:949-63. 2010
    ..The present article focuses on the functions of NFkappaB, its role in human cancer and the therapeutic potential and benefit of targeting NFkappaB by natural products in cancer chemoprevention.
  6. pmc Randomized, double-blind, placebo-controlled trial of monthly versus bimonthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria
    Khin Maung Lwin
    Shoklo Malaria Research Unit, Mae Sod, Thailand
    Antimicrob Agents Chemother 56:1571-7. 2012
    ..DPm is safe to use and is effective in the prevention of malaria in adult males living in an area where P. vivax and multidrug-resistant P. falciparum malaria are endemic...
  7. ncbi Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications
    Young Sam Keum
    Department of Biochemistry, College of Pharmacy, Dongguk University, 813 Siksa dong, Goyang, Kyunggi Do, 410 773, Republic of Korea
    Ann N Y Acad Sci 1229:184-9. 2011
    ....
  8. ncbi Cancer chemoprevention by targeting the epigenome
    Joseph Huang
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Curr Drug Targets 12:1925-56. 2011
    ..and miRNAs deregulated during carcinogenesis have potential impact on multiple mechanisms relevant for chemoprevention, including signal transduction mediated by nuclear receptors and transcription factors such as NF-κB, cell ..
  9. ncbi Oral preexposure anti-HIV prophylaxis for high-risk U.S. populations: current considerations in light of new findings
    Gavin M Myers
    Alpert Medical School of Brown University, Department of Community Health, Providence, Rhode Island, USA
    AIDS Patient Care STDS 25:63-71. 2011
    ..This article considers biological, policy, and practical implications of large-scale oral PrEP implementation...
  10. ncbi Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds
    R Sinha
    Division of Cancer Etiology and Prevention, American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Curr Cancer Drug Targets 4:13-28. 2004
    ..organoselenium compounds need to be examined both in vitro and in vivo for their potential to induce apoptosis; such an investigation may provide better and mechanism-based cancer chemoprevention as well as chemotherapeutic agents.
  11. pmc Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection
    Peter L Anderson
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA
    J Antimicrob Chemother 66:240-50. 2011
    ..The current state of knowledge in these areas is summarized and the future utility of intracellular pharmacokinetics/pharmacodynamics for the PrEP field is discussed...
  12. ncbi Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study
    Saverio Bettuzzi
    Department of Medicina Sperimentale, Sezione di Biochimica, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Cancer Res 66:1234-40. 2006
    ..This prompted us to do a proof-of-principle clinical trial to assess the safety and efficacy of GTCs for the chemoprevention of CaP in HG-PIN volunteers...
  13. ncbi Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways
    Sonia Ramos
    Department of Metabolism and Nutrition, Instituto del Frio, Consejo Superior de Investigaciones Cientificas CSIC, Ciudad Universitaria, Madrid, Spain
    Mol Nutr Food Res 52:507-26. 2008
    ....
  14. ncbi Chemoprevention, chemotherapy, and chemoresistance in colorectal cancer
    Jose J G Marin
    Department of Physiology and Pharmacology, University of Salamanca, CIBERehd, Salamanca, Spain
    Drug Metab Rev 44:148-72. 2012
    ..b>Chemoprevention is a promising approach, but studies demonstrating their usefulness in large populations are still needed...
  15. ncbi Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention
    Kyung Soo Chun
    Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, 151 742, South Korea
    Biochem Pharmacol 68:1089-100. 2004
    ..or improperly elevated COX-2 provides one of the most effective and promising strategies for cancer chemoprevention. The COX-2 promoter contains a TATA box and binding sites for several transcription factors including nuclear ..
  16. ncbi Natural isothiocyanates: genotoxic potential versus chemoprevention
    Carmela Fimognari
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Mutat Res 750:107-31. 2012
    ....
  17. ncbi Interaction between epidermal growth factor receptor- and cyclooxygenase 2-mediated pathways and its implications for the chemoprevention of head and neck cancer
    Mi Sun Choe
    Department of Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Mol Cancer Ther 4:1448-55. 2005
    Head and neck squamous cell carcinoma is a well-known model for chemoprevention studies because of its field cancerization effect, its multistep carcinogenesis process, and the easy accessibility of biopsies to target lesions...
  18. ncbi Chemoprevention of breast cancer with selective oestrogen-receptor modulators
    V Craig Jordan
    Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111 2497, USA
    Nat Rev Cancer 7:46-53. 2007
    ..New medicines now promise to provide chemoprevention strategies for women at risk for the development of many diseases.
  19. pmc HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness
    A David Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520 8034, USA
    Clin Infect Dis 48:806-15. 2009
    ..We sought to forecast clinical, epidemiologic, and economic outcomes of PrEP, taking into account uncertainties regarding efficacy, the risks of developing drug resistance and toxicity, behavioral disinhibition, and drug costs...
  20. ncbi Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials
    Adeeb Shehzad
    School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Arch Pharm (Weinheim) 343:489-99. 2010
    ..Currently, sufficient data has been shown to advocate phase II and phase III clinical trials of curcumin for a variety of cancer conditions including multiple myeloma, pancreatic, and colon cancer...
  21. pmc Cost risk benefit analysis to support chemoprophylaxis policy for travellers to malaria endemic countries
    Eduardo Massad
    School of Medicine, University of Sao Paulo and LIM 01 HCFMUSP, Brazil
    Malar J 10:130. 2011
    ..To evaluate whether current malaria chemo-prophylactic policy for travellers is cost effective when adjusted for endemic transmission risk and duration of exposure. a framework, based on partial cost-benefit analysis was used...
  22. ncbi Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials
    F I Abdullaev
    Laboratorio Oncologia Experimental, Instituto Nacional de Pediatria, Avenida Imán 1 Torre de Investigación, 04530 Mexico D F, Mexico
    Cancer Detect Prev 28:426-32. 2004
    b>Chemoprevention strategies are very attractive and have earned serious consideration as potential means of controlling the incidence of cancer...
  23. ncbi Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms
    Young Sam Keum
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Mutat Res 555:191-202. 2004
    b>Chemoprevention is a cancer preventive strategy to inhibit, delay or reverse carcinogenesis using naturally occurring or synthetic chemical agents...
  24. ncbi Cancer chemoprevention by natural products: how far have we come?
    Rajendra G Mehta
    Carcinogenesis and Chemoprevention Division, IIT Research Institute, 10 West 35th Street, Chicago, Illinois 60616, USA
    Pharm Res 27:950-61. 2010
    ..The term chemoprevention was coined in the late 1970s and referred to the prevention of cancer by selective use of phytochemicals or ..
  25. pmc Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research
    Yiwei Li
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Pharm Res 27:1027-41. 2010
    ....
  26. ncbi Chemoprevention with phytochemicals targeting inducible nitric oxide synthase
    Akira Murakami
    Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Forum Nutr 61:193-203. 2009
    ....
  27. pmc Chemoprevention strategies for pancreatic cancer
    Silvia D Stan
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, 5117 Centre Avenue, 2 31 Hillman Cancer Center, Pittsburgh, PA 15213, USA
    Nat Rev Gastroenterol Hepatol 7:347-56. 2010
    ..This Review discusses the current state of the pancreatic cancer chemoprevention field and highlights the challenges ahead.
  28. ncbi Cancer chemoprevention: a radical perspective
    Numsen Hail
    Department of Pharmaceutical Sciences, The University of Colorado Denver School of Pharmacy, Denver, CO 80220, USA
    Free Radic Biol Med 45:97-110. 2008
    ..support the hypothesis that reactive oxygen species and cellular redox tone are exploitable targets in cancer chemoprevention via the stimulation of cytoprotection in normal cells and/or the induction of apoptosis in transformed cells.
  29. pmc Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide
    Marie Lue Antony
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Indian J Exp Biol 49:805-16. 2011
    ..This article reviews mechanisms and targets of cancer chemoprevention by DATS.
  30. pdf Cancer chemoprevention by carotenoids
    Takuji Tanaka
    Tohkai Cytopathology Institute, Cancer Research and Prevention TCI CaRP, 5 1 2 Minami Uzura, Gifu 500 8285, Japan
    Molecules 17:3202-42. 2012
    ..Since chemoprevention is one of the most important strategies in the control of cancer development, molecular mechanism-based ..
  31. pmc Pre-exposure prophylaxis and antiretroviral resistance: HIV prevention at a cost?
    Christopher B Hurt
    Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
    Clin Infect Dis 53:1265-70. 2011
    ..Here, we discuss the impact of signature mutations selected by PrEP, how rapidly these emerge with daily ARV exposure, and the individual-level and public health consequences of ARV resistance...
  32. ncbi Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies
    N S Murthy
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    J Postgrad Med 55:45-54. 2009
    ..Studies on adiponectin analogues or adiponectin receptor agonists are a promising area of cancer chemoprevention research...
  33. pmc Prospects, achievements, challenges and opportunities for scaling-up malaria chemoprevention in pregnancy in Tanzania: the perspective of national level officers
    Godfrey M Mubyazi
    National Institute for Medical Research, Dar es Salaam, Tanzania
    Malar J 7:135. 2008
    ....
  34. ncbi Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
    Cancer Lett 252:1-8. 2007
    ..An understanding of this dual role of H(2)O(2) in cancer might be exploited for the development of cancer chemopreventive and therapeutic strategies...
  35. pmc The position of mefloquine as a 21st century malaria chemoprophylaxis
    Patricia Schlagenhauf
    University of Zurich Centre for Travel Medicine, Hirschengraben 84, University of Zurich, Switzerland
    Malar J 9:357. 2010
    ..Malaria chemoprophylaxis prevents the occurrence of the symptoms of malaria. Travellers to high-risk Plasmodium falciparum endemic areas need an effective chemoprophylaxis...
  36. pmc Chemoprevention in familial adenomatous polyposis
    Brian Kim
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Best Pract Res Clin Gastroenterol 25:607-22. 2011
    ..Curcumin and eicosapentaenoic acid show efficacy in small clinical trials of FAP chemoprevention. This article will review the concept of chemoprevention and the current clinical literature in FAP ..
  37. ncbi Chemoprevention of azoxymethane-initiated colon cancer in rat by using a novel polymeric nanocarrier--curcumin
    Ali Mohammad Alizadeh
    Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol 689:226-32. 2012
    ..More investigations are needed to confirm its safety for human use...
  38. ncbi Aminosalicylate therapy in the prevention of dysplasia and colorectal cancer in ulcerative colitis
    David T Rubin
    The Reva and David Logan Center for Research in Gastrointestinal Diseases, University of Chicago, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 4:1346-50. 2006
    ..Aminosalicylates have been suggested as chemopreventive agents for colorectal cancer (CRC) in ulcerative colitis (UC). We studied the effect of aminosalicylate use on dysplasia and CRC risk in chronic UC...
  39. pmc Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina
    Mohamed F Ismail
    Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt
    Int J Biol Sci 5:377-87. 2009
    ..This is the first report of the in vivo chemopreventive effect of SP against DBN-induced rat liver cytotoxicity and carcinogenesis, suggesting its potential use in chemoprevention of cancer.
  40. pmc Patterns of case management and chemoprevention for malaria-in-pregnancy by public and private sector health providers in Enugu state, Nigeria
    Ogochukwu C Onwujekwe
    Department of Pharmacy, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu State, Nigeria
    BMC Res Notes 5:211. 2012
    ..Information is required on how to improve its prevention and treatment from both the providers' and consumers' perspectives...
  41. ncbi Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats
    Anupam Bishayee
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
    J Nutr Biochem 22:1035-46. 2011
    ..These results along with a safety profile of BCSE encourage the development of black currant bioactive constituents as chemopreventive agents for human liver cancer...
  42. pmc Metabolism as a key to histone deacetylase inhibition
    Praveen Rajendran
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Crit Rev Biochem Mol Biol 46:181-99. 2011
    ..g. pyruvate), the yin-yang of HDAC inhibition versus HDAC activation, and the screening assays that might be most appropriate for discovery of novel HDAC inhibitors in the future...
  43. ncbi Epigenetic impact of dietary isothiocyanates in cancer chemoprevention
    Clarissa Gerhauser
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Curr Opin Clin Nutr Metab Care 16:405-10. 2013
    ..The present report will summarize novel findings of ITCs on histone deacetylase activity, DNA methylation, and short noncoding microRNAs, focusing on sulforaphane (SFN) from broccoli and phenethylisothiocyanate from watercress...
  44. ncbi Spanish travelers to high-risk areas in the tropics: airport survey of travel health knowledge, attitudes, and practices in vaccination and malaria prevention
    Rogelio Lopez-Velez
    Tropical Medicine and Clinical Parasitology, Infectious Diseases Department, Hospital Ramon y Cajal, Madrid, Spain
    J Travel Med 14:297-305. 2007
    ..To evaluate travel health knowledge, attitudes, and practices on vaccination and malaria prevention among Spanish travelers to the tropics...
  45. pmc A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention
    Allen Y Chen
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA
    Food Chem 138:2099-107. 2013
    ..b>Chemoprevention using nanotechnology to improve the bioavailability of kaempferol is also discussed.
  46. pmc Impact of maternal and infant antiretroviral drug regimens on drug resistance in HIV-infected breastfeeding infants
    Jessica M Fogel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pediatr Infect Dis J 32:e164-9. 2013
    ..HIV-uninfected infants (the intent-to-treat group) received daily NVP or placebo up to 6 months of age. We analyzed emergence of NVP resistance in infants who acquired HIV infection despite prophylaxis...
  47. ncbi New molecular and cellular targets for chemoprevention and treatment of skin tumors by plant polyphenols: a critical review
    L G Korkina
    Lab Tissue Engineering and Skin Pathophysiology, Dermatology Institute Istituto Dermopatico dell Immacolata, IDI IRCCS, Via Monti di Creta 104, Rome 00167, Italy
    Curr Med Chem 20:852-68. 2013
    ..in dermatological/cosmeceutical compositions for the prevention, slowing, or reversion of skin tumorigenesis (chemoprevention)...
  48. pmc Nanochemoprevention by bioactive food components: a perspective
    Imtiaz A Siddiqui
    Department of Dermatology, University of Wisconsin, Medical Sciences Center B 25, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Pharm Res 27:1054-60. 2010
    b>Chemoprevention through the use of bioactive food components is a practical approach for cancer control. Despite abundant efficacy data under preclinical settings, this strategy has resulted in limited success for human cancer control...
  49. ncbi Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Cancer Res 63:7005-31. 2003
    Research on cancer chemoprevention is an important approach for decreasing both the incidence and number of deaths from cancer...
  50. pmc A qualitative study of provider thoughts on implementing pre-exposure prophylaxis (PrEP) in clinical settings to prevent HIV infection
    EMILY A ARNOLD
    Center for AIDS Prevention Studies, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e40603. 2012
    ..We explored how medical and service providers understand research results and plan to develop clinical protocols to prescribe, support and monitor adherence for patients on PrEP in the United States...
  51. ncbi Molecular basis for cancer chemoprevention by green tea polyphenol EGCG
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, Japan
    Forum Nutr 61:156-69. 2009
    ..Our data shed new light on the molecular basis for the cancer-preventive activity of EGCG in vivo and helps in the design of new strategies to prevent cancer...
  52. ncbi Predictors of rapid HIV testing acceptance and successful nevirapine administration in Zambian labor wards
    Karen M Megazzini
    School of Public Health, Department of Epidemiology, University of Alabama, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 52:273-9. 2009
    ..Provision of HIV testing in labor provides an opportunity to reach susceptible women and infants...
  53. ncbi Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
    C A Elmets
    Department of Dermatology, Case Western Reserve, Cleveland, Ohio, USA
    J Am Acad Dermatol 44:425-32. 2001
    ..CONCLUSION: Polyphenolic extracts of green tea are effective chemopreventive agents for many of the adverse effects of sunlight on human health and may thus serve as natural alternatives for photoprotection...
  54. pmc Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
    Anupam Bishayee
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272, USA
    Front Biosci (Landmark Ed) 16:980-96. 2011
    ..This review examines the potential role of natural triterpenoids and their derivatives in the chemoprevention and treatment of mammary tumors...
  55. pmc Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis
    Wei Qiu
    University of Pittsburgh Cancer Institute and Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 107:20027-32. 2010
    ..These results suggest that effective chemoprevention of colon cancer by NSAIDs lies in the elimination of stem cells that are inappropriately activated by ..
  56. ncbi NSAID inhibition of GI cancer growth: clinical implications and molecular mechanisms of action
    Syeda S Husain
    Medical Service, Department of Veterans Affairs Medical Center, Long Beach, California, USA
    Am J Gastroenterol 97:542-53. 2002
    ....
  57. ncbi Cyclooxygenase as a target for colorectal cancer chemoprevention
    Leticia Moreira
    Gastroenterology Department, Hospital Clinic, CIBERehd, IDIBAPS, University of Barcelona, Catalonia, Spain
    Curr Drug Targets 12:1888-94. 2011
    ..In this article, we will review the role of cyclooxygenase as a target for CRC chemoprevention, with special attention to the use of selective and non-selective COX-2 inhibitors in both individuals ..
  58. ncbi Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases
    Masahito Shimizu
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan
    Mol Nutr Food Res 55:832-43. 2011
    ....
  59. pmc Uptake of prevention of mother to child transmission interventions in Kenya: health systems are more influential than stigma
    John Kinuthia
    Department of Obstetrics and Gynaecology, Kenyatta National Hospital University of Nairobi, Kenya
    J Int AIDS Soc 14:61. 2011
    ....
  60. ncbi Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis
    Anupam Bishayee
    Department of Pharmaceutical Sciences Cancer Therapeutics and Chemoprevention Emphasis Group, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown Ohio, 44272, USA
    Pharm Res 27:1080-91. 2010
    ..The current study was designed to explore whether the antiinflammatory properties of resveratrol play a role in its antihepatocarcinogenic action...
  61. ncbi Ins and outs of dietary phytochemicals in cancer chemoprevention
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 74:533-44. 2007
    ..This review will critically discuss the applications of chemical and dietary chemoprevention, intending the protecting effects against cancer of chemically synthesized molecules, or phytochemicals ..
  62. ncbi Role of oxidative stresses induced by diesel exhaust particles in airway inflammation, allergy and asthma: their potential as a target of chemoprevention
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Inflamm Allergy Drug Targets 9:300-5. 2010
    ..Therefore, chemoprevention against DEPs health effects in susceptible individuals may become a choice for future environmental ..
  63. ncbi Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: the value of genomics biomarkers in molecular epidemiology
    Theo M C M de Kok
    Department of Health Risk Analysis and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    Mol Nutr Food Res 54:208-17. 2010
    ..The use of genomics techniques appears to be a promising approach to establish mechanistic pathways involved in chemoprevention by phytochemicals, particularly when genetic variability is taken into account.
  64. pmc Placental malaria and low birth weight in pregnant women living in a rural area of Burkina Faso following the use of three preventive treatment regimens
    Alfred B Tiono
    Centre National de Recherche et de Formation sur le Paludisme, Ministere de la Sante, Ouagadougou, Burkina Faso
    Malar J 8:224. 2009
    ....
  65. ncbi Use of selenium in chemoprevention of bladder cancer
    Maree Brinkman
    Department of General Practice, Katholieke University of Leuven, Leuven, Belgium
    Lancet Oncol 7:766-74. 2006
    ..recurrence rate and ability to monitor bladder urothelial-cell carcinoma make selenium a good candidate for chemoprevention. Evidence suggests that selenium is a biologically plausible, safe, and efficacious potential chemoprevention ..
  66. ncbi A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer
    D M Heijink
    Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Oncogene 30:2026-36. 2011
    ..All inhibitors used induced cell growth reduction in adenoma cells. This study shows a bioinformatical and functional approach leading to potentially new options for chemoprevention of colorectal cancer.
  67. ncbi Diet and prostate cancer: mechanisms of action and implications for chemoprevention
    Vasundara Venkateswaran
    Division of Urology, MG 408, Sunnybrook Health Sciences Center and Department of Surgery, University of Toronto, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
    Nat Rev Urol 7:442-53. 2010
    ..Until large randomized trials confirm the benefit of chemopreventive and dietary modifications, patients can be advised to pursue a diet and lifestyle that enhances overall health...
  68. pmc Silymarin and epithelial cancer chemoprevention: how close we are to bedside?
    Manjinder Kaur
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Toxicol Appl Pharmacol 224:350-9. 2007
    ....
  69. ncbi Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice
    Ralf Schubert
    Department of Pediatrics, The Comprehensive Cancer Center, UCSD School of Medicine, La Jolla, CA 92093 0627, USA
    Hum Mol Genet 13:1793-802. 2004
    ..and the observed increased ROS in cancerous tissues suggest that antioxidants may be used in cancer chemoprevention. We tested this hypothesis by determining whether the well-described nitroxide antioxidant, tempol (4-hydroxy-..
  70. ncbi Superiority of 3 over 2 doses of intermittent preventive treatment with sulfadoxine-pyrimethamine for the prevention of malaria during pregnancy in mali: a randomized controlled trial
    Oumou S Maïga Diakite
    Department of Health System Information, National Directorate of Health, University of Bamako, Bamako, Mali
    Clin Infect Dis 53:215-23. 2011
    ..The aim of the study was to compare the efficacy and safety of 3-dose versus 2-dose IPTp-SP for the prevention of placental malaria and associated low birth weight (LBW)...
  71. pmc The incidence of malaria in travellers to South-East Asia: is local malaria transmission a useful risk indicator?
    Ron H Behrens
    Travel Clinic, Hospital for Tropical Diseases, Mortimer Market, London, WC1E 6JB, UK
    Malar J 9:266. 2010
    ..The study was designed to examine whether the strategy of using malaria transmission in a local population was an accurate estimate of the malaria threat faced by travellers and a correlate of malaria in returning travellers...
  72. pmc The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1
    G A Potter
    Cancer Drug Discovery Group, School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK
    Br J Cancer 86:774-8. 2002
    ..Importantly this result gives insight into the functional role of CYP1B1 and provides evidence for the concept that CYP1B1 in tumours may be functioning as a growth suppressor enzyme...
  73. ncbi Curcumin for chemoprevention of colon cancer
    Jeremy James Johnson
    University of Wisconsin, School of Pharmacy, 777 Highland Avenue, Madison, WI 53705 2222, USA
    Cancer Lett 255:170-81. 2007
    ..that safer compounds, especially those derived from natural sources must be critically examined for chemoprevention. A spice common to India and the surrounding regions, is turmeric, derived from the rhizome of Curcuma longa...
  74. ncbi Chemoprevention meets glucose control
    Jeffrey A Engelman
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Room 7408, Charlestown, MA 02129, USA
    Cancer Prev Res (Phila) 3:1049-52. 2010
    ..These potential mechanisms are discussed in this perspective, as are their implications for cancer prevention and therapy...
  75. pmc Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistance
    Whitney E Harrington
    Malaria Program, Seattle Biomedical Research Institute, Seattle, Washington, USA
    Clin Infect Dis 53:224-30. 2011
    ..However, parasites resistant to SP are widespread in parts of Africa, and IPTp may perversely exacerbate placental infections that contain SP-resistant parasites...
  76. ncbi Epidemiology, treatment and chemoprevention in colorectal cancer
    P Rougier
    Hospital Ambroise Pare, Boulogne Billancourt, France
    Ann Oncol 14:ii3-5. 2003
    ..Much CRC is familial, raising the prospect of targeted screening to aid early detection. Since the molecular events leading to CRC have become better characterized, there is also the possibility of developing chemoprotective agents...
  77. ncbi Molecular basis of traditional Chinese medicine in cancer chemoprevention
    Steven Wang
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, 309 E Second Street, Pomona, CA 91766, USA
    Curr Drug Discov Technol 7:67-75. 2010
    Cancer is the second leading cause of death, for which current therapeutic approaches are still very limited. Chemoprevention is an important approach to decreasing cancer morbidity and mortality by the use of non-toxic natural or ..
  78. ncbi Recent advances in chemoprevention of cancer
    W K Hong
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 80, Houston, TX 77030, USA
    Science 278:1073-7. 1997
    b>Chemoprevention is the use of pharmacologic or natural agents that inhibit the development of invasive cancer either by blocking the DNA damage that initiates carcinogenesis or by arresting or reversing the progression of premalignant ..
  79. pmc Antiretroviral agents used by HIV-uninfected persons for prevention: pre- and postexposure prophylaxis
    Robert M Grant
    Gladstone Institute of Virology and Immunology and University of California, San Francisco, USA
    Clin Infect Dis 50:S96-101. 2010
    ..Future implementation, if warranted, will be guided by the results of clinical trials in progress and engagement of communities exposed to HIV...
  80. ncbi Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials
    Okezie I Aruoma
    Faculty of Health and Social Care, London South Bank University, 103 Borough Road, London SE1 0AA, UK
    Biofactors 27:245-65. 2006
    ..The senescence-accelerated strain of mice (SAM) are models of senescence acceleration and geriatric disorders which exhibit learning and memory deficits and enhanced production or defective control of oxidative stress leading...
  81. ncbi Targeting the AKT protein kinase for cancer chemoprevention
    James A Crowell
    Division of Cancer Prevention, National Cancer Institute, NIH, Executive Plaza North, Room 2117, 900 Rockville Pike, Bethesda, MD 20892, USA
    Mol Cancer Ther 6:2139-48. 2007
    ....
  82. pmc Malaria chemoprophylaxis: strategies for risk groups
    Patricia Schlagenhauf
    University of Zurich Centre for Travel Medicine, WHO Collaborating Centre for Travellers Health, Institute for Social and Preventive Medicine, University of Zurich, Zurich, Switzerland
    Clin Microbiol Rev 21:466-72. 2008
    ..So far, malaria prophylaxis is recommended to prevent Plasmodium falciparum infections, and primaquine prophylaxis against persistent Plasmodium vivax and Plasmodium ovale infections in travelers is not recommended...
  83. ncbi Chemoprevention by isothiocyanates: molecular basis of apoptosis induction
    Yoshimasa Nakamura
    Department of Biofunctional Chemistry, Okayama University, Okayama, Japan
    Forum Nutr 61:170-81. 2009
    ..This review addresses the biological impact of cell death induction by BITC as well as other ITCs and the involved molecules regulating signal pathways...
  84. ncbi Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis
    Joydeb Kumar Kundu
    College of Pharmacy, Seoul National University, 599 kwanak Ro, Kwanak Ku, Seoul 151 742, South Korea
    Pharm Res 27:999-1013. 2010
    ..Thus, Nrf2-mediated cytoprotective gene induction is an effective strategy for the chemoprevention of inflammation-associated carcinogenesis.
  85. pmc Community response to intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in five African settings
    Marjolein Gysels
    Centre for International Health Research CRESIB, University of Barcelona, Spain
    Malar J 8:191. 2009
    ....
  86. pmc Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, C218 Banting Building, Postal Locator 2202D, Ottawa, K1A 0L2, Ontario, Canada
    World J Gastroenterol 14:6632-5. 2008
    ..In chemoprevention studies, AOM-induced rat ACF have been very successful as biomarkers, and have provided several standardized ..
  87. ncbi Mechanisms of combined action of different chemopreventive dietary compounds: a review
    Theo M de Kok
    Department of Health Risk Analysis and Toxicology, University of Maastricht, Maastricht, The Netherlands
    Eur J Nutr 47:51-9. 2008
    ..In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of ..
  88. ncbi Failure of a chloroquine chemoprophylaxis program to adequately prevent malaria during pregnancy in Koupéla District, Burkina Faso
    Sodiomon B Sirima
    Centre National de Recherche et de Formation sur le Paludisme, Ministere de la Sante, Ouagadougou
    Clin Infect Dis 36:1374-82. 2003
    ..Alternative prevention strategies, such as use of insecticide-treated mosquito nets and intermittent preventive treatment with more-effective antimalarials, are needed...
  89. ncbi Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state
    Numsen Hail
    Department of Pharmaceutical Sciences, The University of Colorado Denver School of Pharmacy, Aurora, CO 80045, USA
    Mol Nutr Food Res 53:49-67. 2009
    Cancer chemoprevention employs agents that block, hinder, or reverse tumorigenesis to prevent malignancy...
  90. ncbi Omega-3 polyunsaturated fatty acids
    Mark A Hull
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, United Kingdom
    Best Pract Res Clin Gastroenterol 25:547-54. 2011
    ..A randomized polyp prevention trial of EPA is underway in order to test chemopreventative efficacy against 'sporadic' colorectal neoplasia...
  91. ncbi The tumour microenvironment as a target for chemoprevention
    Adriana Albini
    IRCCS Multimedica Science and Technology Park, Viale Fantoli 15 16, Milan, 20138, Italy
    Nat Rev Cancer 7:139-47. 2007
    ..These recent findings make a compelling case for targeting the microenvironment for cancer chemoprevention. We review new insights into the pathophysiology of the microenvironment and new approaches to control it ..
  92. pmc Interactions between Global Health Initiatives and country health systems: the case of a neglected tropical diseases control program in Mali
    Anna Cavalli
    Public Health Department, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS Negl Trop Dis 4:e798. 2010
    ....
  93. ncbi Chemoprevention of prostate cancer: an updated view
    Eric A Klein
    Glickman Urological and Kidney Institute, Desk Q10 1, 9500 Euclid Ave, Cleveland, OH 44122, USA
    World J Urol 30:189-94. 2012
    To place chemoprevention of prostate cancer in current clinical context.
  94. ncbi Early modulation of gene expression used as a biomarker for chemoprevention in a preclinical model of colon carcinogenesis
    Souad Bousserouel
    University of Strasbourg, Unit EA4438, Laboratory of Nutritional Cancer Prevention, IRCAD EITS, Strasbourg, France
    Pathol Int 61:80-7. 2011
    ..Here, we identify several target genes that could be considered early biomarkers of colon carcinogenesis and indicative of drug efficacy...
  95. pmc Sites of alkylation of human Keap1 by natural chemoprevention agents
    Yan Luo
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, Illinois, USA
    J Am Soc Mass Spectrom 18:2226-32. 2007
    ..residues toward specific electrophiles should help clarify this mechanism of cancer prevention, also known as chemoprevention. To address this issue, preliminary analyses of tryptic digests of Keap1 alkylated by the model electrophile ..
  96. ncbi American ginseng: potential structure-function relationship in cancer chemoprevention
    Lian Wen Qi
    Tang Center for Herbal Medicine Research, Department of Anesthesia and Critical Care, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, United States
    Biochem Pharmacol 80:947-54. 2010
    ..research on Asian ginseng, studies of American ginseng are relatively limited, especially regarding cancer chemoprevention. In recent studies of American ginseng, steaming or heating altered the ginsenoside profile and thereby ..
  97. ncbi [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin
    Sue Ok Kim
    College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Oncogene 24:2558-67. 2005
    ..One of the well-recognized molecular targets for chemoprevention is cyclooxygenase-2 (COX-2) that is abnormally upregulated in many premalignant and malignant tissues and ..
  98. ncbi The effect of intermittent preventive treatment during pregnancy on malarial antibodies depends on HIV status and is not associated with poor delivery outcomes
    Elisa Serra-Casas
    Barcelona Centre for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 201:123-31. 2010
    ..However, studies reporting the effect of IPTp on malaria-specific immunity are scarce and are based on findings in human immunodeficiency virus (HIV)-negative primigravidae...
  99. pmc Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention?
    Soumen Bera
    Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA
    Mutagenesis 28:127-34. 2013
    ....
  100. ncbi Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention
    Bandaru S Reddy
    Division of Nutritional Carcinogenesis, Institute for Cancer Prevention, Valhalla, New York, NY 10595, USA
    Environ Mol Mutagen 44:26-35. 2004
    ..The development of strategies for the chemoprevention of colorectal cancer have been facilitated by the use of relevant animal models mimicking the neoplastic ..
  101. pmc Implementing preventive chemotherapy through an integrated National Neglected Tropical Disease Control Program in Mali
    Massitan Dembele
    Programme National d Elimination de Filariose Lymphatique du Mali, Bamako, Mali
    PLoS Negl Trop Dis 6:e1574. 2012
    ..The paper reports on the implementation of the integrated mass drug administration and the lessons learned...

Research Grants69

  1. Calcium, Vitamin D, and Markers of Adenomatous Polyps
    Roberd Bostick; Fiscal Year: 2006
    ..been no clinical trials involving vitamin D individually or jointly with calcium related to colorectal cancer chemoprevention in humans. There are currently no generally accepted pre-neoplastic biomarkers of risk for colorectal cancer...
  2. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..systemic toxicities, promising results from these preclinical experiments can be readily translated into a chemoprevention schemes or combined chemo-radiation therapy protocol for treating head and neck cancers...
  3. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..and molecular processes involved in sporadic CRC carcinogenesis and identify agents to novel targets for chemoprevention. Sporadic colorectal cancer is a leading cause of cancer and cancer death worldwide...
  4. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..project is to develop Oriental herbal compound 1,2,3,4,6-penta-O-galloyl- beta-D-glucose (PGG) for the chemoprevention of prostate cancer (PCa), the number 2 cause of cancer death in US men...
  5. Role and Regulation of INrf2
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..better understanding of the mechanisms of the cellular protection against oxidative/electrophilic stress and chemoprevention. The studies may also provide the basis for further analysis of identified targets (cis- and trans-elements) ..
  6. Prevention of UV-induced carcinogenesis by cyanidin-3-glucoside
    Xianglin Shi; Fiscal Year: 2013
    ..In addition to sunscreens, chemoprevention of skin cancer by natural non-toxic compounds is suggested as an effective strategy to prevent the incidence ..
  7. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..Furthermore, n-3 PUFA chemoprevention and chemointervention might similarly be applied to workers who are at increased risk of autoimmunity from ..
  8. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..We have identified the Keap1-Nrf2-ARE signaling pathway as a target for chemoprevention. The Nrf2 transcription factor regulates an integrated cell survival response that can be triggered by ..
  9. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    ..concentrated in the urine, it is plausible that bioactive agents in plants may play a role in bladder cancer chemoprevention. Flavokawain A is the predominant chalcone identified from kava root extract...
  10. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..The development of a viable chemoprevention strategy targeting current smokers potentially could decrease lung cancer mortality...
  11. Biomarkers to Assess Selenium Chemoprevention for NSCLC
    Steven A Belinsky; Fiscal Year: 2012
    ..This finding has led to the implementation of ECOG 5597, "A Phase III Chemoprevention Trial of Selenium Supplementation in Persons with Resected Stage I Non-Small Cell Lung Cancer...
  12. Exploratory Studies on the Anti-Breast Cancer Function of Bamboo Extract
    Jun Panee; Fiscal Year: 2010
    ..the product, and eventually applying this abundant, easily available and sustainable natural resource in the chemoprevention of breast cancer in human subjects...
  13. Statins &Lymphoid Malignancy Risk in a Large Multi-Site Population-Based Cohort
    Marianne Ulcickas Yood; Fiscal Year: 2013
    ..An additional examination that will be included in this study (Aim 2) could lead to effective chemoprevention strategies for persons at high risk for lymphoma. Like most systemic agents, statins are not risk-free...
  14. Mechanisms of tumor suppressor gene reactivation in colon cancer by berries
    Li Shu Wang; Fiscal Year: 2013
    ..Therefore, the prevention of colon cancer remains an important goal and chemoprevention is a viable approach to achieve this goal...
  15. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ..the role of plasma lipid markers in identifying women at high risk of cancer who would most benefit from chemoprevention or increased screening and the role of long-term use of statins in cancer chemoprevention...
  16. Developing a murine model for arsenic-induced skin neoplasm
    Mohammad Athar; Fiscal Year: 2010
    ..utilizing a highly relevant murine model and could lead to important advances in mechanism-based chemoprevention of these skin neoplasms in arsenic-exposed humans...
  17. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..The development of a viable chemoprevention strategy targeting high risk women could have a significant impact on breast cancer morbidity and mortality...
  18. The influence of selenium on biomarkers of prostate cancer risk
    KARAM E EL-BAYOUMY; Fiscal Year: 2012
    ..tailoring of selenium agents (form and dose) as a function of age for the purpose of a more effective chemoprevention program...
  19. Foxf1 Transcription Factor in Development of Pulmonary Capillaries
    Vladimir V Kalinichenko; Fiscal Year: 2013
    ..plays a key role in both these processes and therefore, targeting the Foxf1 can be beneficial for both chemoprevention and treatment of children with BPD...
  20. Combined use of green tea and quercetin in prostate cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2012
    ..limited bioavailability and high metabolism (conjugation and methylation) may decrease the potential of GT in chemoprevention. We determined that 50 percent or more of GTPs in human prostate tissue and urine is found in methylated form ..
  21. Validation of a multi-gene test for lung cancer risk
    James C Willey; Fiscal Year: 2010
    ..An accurate LCRT may be used to design more efficient lung cancer screening and/or chemoprevention studies by enabling enrollment of the highest risk individuals, resulting in lower false positives and lower ..
  22. Amoeboid Membrane Dynamics in Prostate Cancer
    Michael R Freeman; Fiscal Year: 2013
    ..data suggest that the DRF3 network may be sensitive to cholesterol- or fatty acid-targeting therapies and/or chemoprevention, which have shown promise in human studies and animal models...
  23. Chemoprevention of Tamoxifen-induced Endometrial cancer by black cohosh and red c
    BIRGIT MARIA DIETZ; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chemoprevention of Tamoxifen-induced Endometrial cancer by black cohosh and red clover Breast cancer is the most common cancer in women...
  24. Gender Selectivity to Colon Cancer Chemoprevention by NSAIDS
    RAMESH K contact WALI; Fiscal Year: 2010
    ..This underscores the need for developing alternate cancer prevention strategies such as chemoprevention. Of the myriad of purported agents, nonsteroidal anti-inflammatory drugs (NSAIDS) have reliably shown a ..
  25. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine J Gudas; Fiscal Year: 2013
    ..selective retinoids bexarotene (LG1069) and LG100268, which have achieved positive results in other cancer chemoprevention models...
  26. PPAR gamma Agonists for Lung Cancer Chemoprevention
    Robert Keith; Fiscal Year: 2013
    ..The majority of lung cancers are now diagnosed in former smokers, emphasizing the need for effective chemoprevention in this large, at-risk population...
  27. Fatty acid desaturase activity, fish oil and colorectal cancer chemoprevention
    Harvey J Murff; Fiscal Year: 2013
    ..of genetically-determined fatty acid desaturase 1 activity on fish oil supplementation for colorectal cancer chemoprevention. Our long-term objectives are to determine genetic factors that might influence the efficacy of fish oil ..
  28. Chemoprevention of Pancreatic Cancer by Capsaicin
    Sanjay K Srivastava; Fiscal Year: 2013
    Principal Investigator: Srivastava, Sanjay K. CHEMOPREVENTION OF PANCREATIC CANCER BY CAPSAICIN Abstract Pancreatic cancer remains the fourth leading cause of cancer-related death in the United States with a median survival of less than ..
  29. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
    ..This work will identify mechanisms of chemoprevention by combined consumption of different protective dietary components and the optimum time during tumorigenesis ..
  30. (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon Cancer
    Yan Chun Li; Fiscal Year: 2013
    ..In Aim 3 we will assess the role of microbial 7[unreadable]-dehydroxylase (7-DH) in VD chemoprevention. We will compare tumorigenesis in gnotobiotic mice mono-associated with Lactobacillus acidophilus lacking 7-..
  31. Green tea effects on gene expression in tobacco users
    Joel L Schwartz; Fiscal Year: 2013
    ..Cancer chemoprevention trials are made difficult by the need to wait many months or years before the potential chemoprevention can ..
  32. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2010
    ..In addition, the establishment of a lung carcinogenesis model in ferrets provides a valuable tool for both lung cancer and carotenoid research fields. ..
  33. Fatty Acid Synthase:Molecular Target for Breast Cancer Therapy &Chemoprevention
    Ruth Lupu; Fiscal Year: 2013
    ..This proposal will provide new insight into the action of FASN inhibitors and the information needed to translate our findings into the clinic. Our goal is to develop novel rationally designed therapeutic approaches for breast cancer. ..
  34. Calcium-sensing receptor signaling in the regulation of colonic epithelial cells
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2012
    ..The completion of the proposed studies will provide a robust intellectual framework for targeting the colonic CaSR in the chemoprevention of CRC in US veterans as well as in the US population at large.
  35. CHEMOPREVENTION OF SKIN CANCER PROGRAM PROJECT
    George Timothy Bowden; Fiscal Year: 2013
    ..that can hit and eradicate these targets ultimately will allow for personalized medical approaches to SCC chemoprevention. A major theme of this PPG fits the scheme of Discovery Development and Delivery...
  36. Chemoprevention by black raspberry in oral cancer induced by DB[a,l]P in mice
    KARAM E EL-BAYOUMY; Fiscal Year: 2013
    ..We have developed such a model and propose to apply it to chemoprevention. Previous studies have demonstrated the ability of diets containing 5-10% freeze-dried black raspberry (BRB) ..
  37. Chemoprevention of Prostate Cancer
    SUSAN AUDREY HALL; Fiscal Year: 2012
    ..Despite major investment by the National Institutes of Health into clinical trials on the subject of the chemoprevention of prostate cancer (prCA), unanswered questions remain regarding finasteride, a 5-alpha reductase inhibitor ..
  38. Role of MAT and SAMe in Colon Cancer Pathogenesis and Treatment
    SHELLY CHI LOO LU; Fiscal Year: 2012
    ..Assess changes in MAT expression during tumor formation and efficacy of SAMe and MTA in chemoprevention and treatment of intestinal tumors [unreadable] we will examine whether SAMe and MTA can prevent spontaneous ..
  39. Regulation and Role of Ornithine Decarboxylase in Cell Proliferation and Cancer
    John L Cleveland; Fiscal Year: 2013
    ..targeting Odc will have widespread benefit in cancer prevention, a fact now validated in ongoing human cancer chemoprevention trials...
  40. Chemoprevention of Colorectal Cancer by Aldose Reductase Inhibition
    Satish K Srivastava; Fiscal Year: 2013
    ....
  41. Prostate Cancer Prevention by Diallyl Trisulfide
    Shivendra Singh; Fiscal Year: 2013
    ..4 resides in potential design of combination regimens involving DATS and inhibitors of survivin for efficient chemoprevention of human prostate cancer...
  42. Chemoprevention of Head &Neck Cancer Using Controlled Release Polymers
    Susan R Mallery; Fiscal Year: 2013
    ..abstract_text> ..
  43. Stat3 in Epitherlial Carcinogenesis
    John DiGiovanni; Fiscal Year: 2012
    ..greater understanding of the role Stat3 plays in epithelial carcinogenesis and its potential as a target for chemoprevention of cancer...
  44. Dual Modality System for Imaging Colon Cancer in Mice
    Jennifer Kehlet Barton; Fiscal Year: 2013
    ..We will then utilize this technology for scientifically-compelling studies of carcinogenesis and chemoprevention/therapy...
  45. Reactivation of Tumor Suppressor Genes in Breast Cancer by Dietary Supplements as
    Zhongfa Liu; Fiscal Year: 2010
    ..it represents an excellent target to develop DNA methylation inhibitors for chemotherapy and chemoprevention. Reactivation of TSGs by azanucleoside DNA methylation inhibitors, such as decitabine and 5-azacitidine will ..
  46. NAC for melanoma chemoprevention
    Douglas Grossman; Fiscal Year: 2010
    ..Conventional cancer chemoprevention usually involves chronic administration of a drug, not taken in conjunction with the oncogenic stimulus (..
  47. Apigenin restores TSP-1 expression in UVB-irradiated keratinocytes
    Jill C Pelling; Fiscal Year: 2013
    ..many antitumorigenic and chemopreventive actions in multiple cell types (9-14), however, the role of TSP-1 in chemoprevention by Api has never been reported...
  48. Role of Genetic Susceptibility in Therapy-related Subsequent Malignancies
    Smita Bhatia; Fiscal Year: 2013
    ..therapy in future cancer populations) and secondary prevention (targeted screening, behavior modification, chemoprevention in survivors)...
  49. The Effect of Diet and Nutrients on the Progression and Treatment of Prostate Can
    George Thomas; Fiscal Year: 2013
    ..and the therapeutic implications of the PML-AMPK pathway in PCa by employing established PCa chemotherapy and chemoprevention protocols...
  50. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2013
    ..and cessation efforts, treatment and screening, to reduce lung cancer mortality motivated an interest in chemoprevention. At present, no effective chemopreventive agent is available for human...
  51. Quercetin to enhance the bioavailability and activity of green tea polyphenols
    SUSANNE MARGARETE HENNING; Fiscal Year: 2013
    ..The results will lay the foundation for future clinical trials to evaluate the interaction of quercetin and GT in chemoprevention of early stages of prostate cancer.
  52. Chemopreventative properties of Medicinal and Food plants of the Lumbee Tribe
    TRACIE LOCKLEAR; Fiscal Year: 2010
    ..Yet, this population has never been investigated for cancer chemoprevention. Among the Lumbee certain medicinal and food plants are associated with cancer treatment and prevention...
  53. TYPE IV SECRETION &SIGNAL TRANSDUCTION IN EHRLICHIOSIS
    Yasuko Rikihisa; Fiscal Year: 2013
    ..The knowledge may not only contribute to developing new efficacious chemotherapy, chemoprevention, and vaccine strategies for these diseases, but also may uncover common themes in obligate intracellular ..
  54. Risk reduction through polyamine inhibition among colorectal carcinoma patients
    JASON ZELL; Fiscal Year: 2012
    ..and survival, thus providing a rationale for tissue polyamine reduction as a strategy for tertiary chemoprevention among colon cancer patients...
  55. p53 Acetylation as a Mechanism in Chemoprevention by Aspirin
    JAYARAMA B GUNAJE; Fiscal Year: 2010
    ..These studies will provide a novel mechanism by which aspirin may exert anticancer effects in DNA damaged cells via acetylation of p53, induction of Bax and inhibition of p21. ..
  56. Importance of Gender in the Chemoprevention of UV induced Skin Cancer
    Tatiana M Oberyszyn; Fiscal Year: 2013
    ..A clearer understanding of the differences in the skin of males and females will ultimately allow for the development of more appropriately targeted prevention and treatment strategies for this most common form of cancer in humans. ..
  57. Curcumin and chemoprevention of H. pylori-associated gastric carcinogenesis
    Rupesh Chaturvedi; Fiscal Year: 2013
    ..However, in the application, we will test the hypothesis that curcumin specifically induces apoptosis in gastric epithelial cells with DNA damage and will thus have an overall effect of decreasing cancer risk. ..
  58. Metformin as a novel chemopreventive agent for prostate cancer
    Xin Li; Fiscal Year: 2013
    ..Our central hypothesis is that metformin acts as a chemoprevention agent to restrict the initiation of prostatic intraepithelial neoplasia (PIN) and the growth of cancer ..
  59. COX GENE REGULATION IN INTESTINAL MYOFIBROBLASTS
    Don Powell; Fiscal Year: 2009
    ..S., is newly diagnosed in 150,000 persons each year. Chemoprevention through cyclooxygenase-2 (COX-2) specific NSAIDs is being proposed as a viable means of reducing the ..
  60. Epigenetic modifications by dietary PEITC in prostate cancer
    Ah Ng Tony Kong; Fiscal Year: 2013
    ..Significance of the Proposed Research: Cancer chemoprevention of PCa through dietary or chemical intervention would be logical and would be tremendous clinical benefit to ..
  61. Sequence Distribution of Tobacco Carcinogen-DNA Adducts
    Natalia Y Tretyakova; Fiscal Year: 2012
    ..epigenetic changes associated with lung cancer, which will facilitate the development of cancer treatment and chemoprevention strategies for individuals at risk...
  62. Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
    Roberd Bostick; Fiscal Year: 2009
    ..TGF , TGF 1), and investigated the biomarkers" responses to calcium and/or vitamin D in a preliminary chemoprevention trial...
  63. Chemoprevention of tobacco carcinogen-induced bladder cancer
    Harikrishna Nakshatri; Fiscal Year: 2011
    ..A successful leukemia trial can be translated immediately to bladder cancer chemoprevention trial for patients with superficial bladder lesions.
  64. MOLECULAR CHEMOPREVENTION MECHANISMS OF TEA POLYPHENOLS
    Steven Stratton; Fiscal Year: 2005
    ..The proposed studies will be performed under the aegis of the Chemoprevention of Skin Cancer Program Project at the University of Arizona...
  65. Cancer Prevention by West African Medicinal Plants
    Michael Wargovich; Fiscal Year: 2007
    ..broad long-term objective is to establish a role for this unexploited source of natural products for future chemoprevention applications for colon and other cancers...
  66. MOLECULAR MECHANISMS OF ASPIRIN IN CANCER PREVENTION
    Zigang Dong; Fiscal Year: 2001
    Aspirin is one of the most promising agents for the chemoprevention of human cancer. The clinical usefulness of aspirin is partially limited by its side effects...
  67. Combinational Chemoprevention of Esophageal Adenocarcin*
    Navtej Buttar; Fiscal Year: 2005
    ..Human studies are underway to assess the chemopreventive effect of COX-2 inhibitors. Combinational chemoprevention, whereby synergism can be achieved between two chemopreventive agents, represents an important development in ..
  68. Chemoprevention of Photocarcinogenesis by Resveratrol
    Nihal Ahmad; Fiscal Year: 2003
    ..b>Chemoprevention by naturally occurring non-toxic compounds is a potential strategy to prevent the occurrence of the disease...
  69. Biomarker modulation/COX-2 inhibitor/Breast Cancer
    Banu Arun; Fiscal Year: 2003
    ..Current research focus is now on the prevention of breast cancer. In that effort, a large phase III chemoprevention trial of tamoxifen showed a reduced incidence of estrogen receptor (ER) positive breast cancer...