- Which drugs cause preventable admissions to hospital? A systematic review
R L Howard
Nottingham Primary Care Research Partnership, Broxtowe and Hucknall PCT, Hucknall Health Centre, Nottingham, UK
Br J Clin Pharmacol 63:136-47. 2007
- National mass drug administration costs for lymphatic filariasis elimination
Ann S Goldman
Department of Epidemiology, The George Washington School of Public Health and Health Services, Washington, DC, United States of America
PLoS Negl Trop Dis 1:e67. 2007
..3 billion people at risk...
- Role of pharmacist counseling in preventing adverse drug events after hospitalization
Jeffrey L Schnipper
Brigham and Women s Faulkner Hospitalist Program, Division of General Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02120 1613, USA
Arch Intern Med 166:565-71. 2006
..Our objectives were to identify drug-related problems during and after hospitalization and to determine the effect of patient counseling and follow-up by pharmacists on preventable ADEs...
- Transporters and drug therapy: implications for drug disposition and disease
Richard H Ho
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Clin Pharmacol Ther 78:260-77. 2005
The efficacy of drug therapy results from the complex interplay of multiple processes that govern drug disposition and response...
- An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremia
Karri A Bauer
Department of Pharmacy, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
Clin Infect Dis 51:1074-80. 2010
..07) and the mean hospital costs were $21,387 less (P = .02). rPCR allows rapid differentiation of S. aureus bacteremia, enabling timely, effective therapy and is associated with decreased length of stay and health care costs...
- ChemProt-2.0: visual navigation in a disease chemical biology database
Sonny Kim Kjærulff
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
Nucleic Acids Res 41:D464-9. 2013
..Filtering options were included in order to facilitate and to guide dynamic search of specific queries...
- Nonspecific medication side effects and the nocebo phenomenon
Arthur J Barsky
Department of Psychiatry, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
JAMA 287:622-7. 2002
- Adverse drug reaction-related hospitalisations: a population-based cohort study
Cornelis S van der Hooft
Pharmaco epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
Pharmacoepidemiol Drug Saf 17:365-71. 2008
..To evaluate the extent, characteristics and determinants of adverse drug reaction (ADR)-related hospitalisations on a population-based level in 2003...
- Evaluation of the quality of drug therapy among elderly patients in nursing homes
Apoteket AB, Goteborg, Sweden
Scand J Prim Health Care 25:9-14. 2007
To evaluate drug therapy quality among elderly nursing home residents. Secondary aims were to compare quality in young and old elderly and to determine whether number of prescribers affected quality of drug therapy.
- The value of inpatient pharmaceutical counselling to elderly patients prior to discharge
S A Al-Rashed
School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK
Br J Clin Pharmacol 54:657-64. 2002
..We have evaluated if these summaries, together with in-patient pharmaceutical counselling backed up with a simple medicine reminder card, may help with the delivery of seamless pharmaceutical care...
- Validity of diagnostic and drug data in standardized nursing home resident assessments: potential for geriatric pharmacoepidemiology. SAGE Study Group. Systematic Assessment of Geriatric drug use via Epidemiology
Istituto di Medicina Interna e Geriatria, Universita Cattolica del Sacro Cuore, Rome, Italy
Med Care 36:167-79. 1998
..The authors sought to ascertain reliability and validity of diagnostic and drug data in a database obtained by merging the Minimum Data Set with detailed information on drugs consumed by each resident...
- Drug-related morbidity and mortality: updating the cost-of-illness model
F R Ernst
College of Pharmacy, University of Arizona, Tucson 85721 0207, USA
J Am Pharm Assoc (Wash) 41:192-9. 2001
..6 billion for the annual cost of drug-related morbidity and mortality resulting from drug-related problems (DRPs) in the ambulatory setting in the United States to reflect current treatment patterns and costs...
- Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study
Department of Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA
Sleep Med 5:237-46. 2004
..To assess the frequency, impact, and medical response to the restless legs syndrome (RLS) in a large multi-national primary care population...
- Pooled analysis of individual patient-level data from all randomized, double-blind, placebo-controlled trials of darbepoetin alfa in the treatment of patients with chemotherapy-induced anemia
Wilhelminenspital, Department of Medicine I, Center for Oncology and Hematology, Pavillion 23, Montleartstrasse 37, Vienna 1160, Austria
J Clin Oncol 27:2838-47. 2009
- Systematic reviews of adverse effects of drug interventions: a survey of their conduct and reporting quality
V R Cornelius
Drug Safety Research Unit, Blundell Lane, Southampton, UK
Pharmacoepidemiol Drug Saf 18:1223-31. 2009
..Methods to systematically review adverse effects have not been fully developed. We aimed to assess the current methods and reporting used by such reviews...
- Association of ICU or hospital admission with unintentional discontinuation of medications for chronic diseases
Chaim M Bell
Department of Health Policy, Management, and Evaluation, Keenan Research Centre in Li Ka Shing Knowledge Institute at St Michael s Hospital, Toronto, Ontario, Canada
JAMA 306:840-7. 2011
..The intensive care unit (ICU) may pose an even greater risk because of the focus on acute events and the presence of multiple transitions in care...
- Should non-inferiority drug trials be banned altogether?
Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, PO Box 80082, 3508TB Utrecht, The Netherlands
Drug Discov Today 18:601-4. 2013
- Incidence and preventability of adverse drug events among older persons in the ambulatory setting
Jerry H Gurwitz
Meyers Primary Care Institute and the University of Massachusetts Medical School, 630 Plantation St, Worcester, Mass 01605, USA
JAMA 289:1107-16. 2003
..Adverse drug events, especially those that may be preventable, are among the most serious concerns about medication use in older persons cared for in the ambulatory clinical setting...
- The expression of aversion to medicines in general practice consultations
Institute of Clinical Education, Peninsula Medical School, Universities of Plymouth and Exeter, St Luke s Campus, Exeter, Devon EX1 2LU, England, UK
Soc Sci Med 59:1495-503. 2004
..The results of this paper suggest that using aversion as an interactional resource might be the only safe way for patients to express their aversion without seeming to breach the social contract...
- Sample size recalculation using conditional power
J S Denne
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, U S A
Stat Med 20:2645-60. 2001
..We do this within the framework of a two-group error-spending sequential test, modified so as to prevent inflation of the type I error rate...
- Frequency of adverse drug reactions in children: a prospective study
Annie Pierre Jonville-Bera
Department of Clinical Pharmacology and Regional Drug Monitoring Centre, University Hospital of Tours, 2 Boulevard Tonellé, 37044 Tours Cedex, France
Br J Clin Pharmacol 53:207-10. 2002
..To assess the frequency of adverse drug reactions (ADRs) in children in France...
- Rankings and symptom assessments of side effects from chemotherapy: insights from experienced patients with ovarian cancer
Charlotte C Sun
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Unit 440, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA
Support Care Cancer 13:219-27. 2005
..Selection of second- or third-line chemotherapy ultimately depends on patient preferences for different side effects. To better understand this process, we evaluated preferences and symptom distress in patients with ovarian cancer...
- 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer
Walter T Hughes
St Jude Children s Research Hospital, Memphis, TN, 38105, USA
Clin Infect Dis 34:730-51. 2002
- Measurement, correlates, and health outcomes of medication adherence among seniors
Shelly A Vik
Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Ann Pharmacother 38:303-12. 2004
..To provide a comprehensive review of the literature on the measurement, correlates, and health outcomes of medication adherence among community-dwelling older adults...
- How to calculate the dose of chemotherapy
Department of Medical Oncology and Palliative Care, Westmead Hospital, Westmead 2145, Australia
Br J Cancer 86:1297-302. 2002
- Indicators for preventable drug related morbidity: application in primary care
C J Morris
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK
Qual Saf Health Care 13:181-5. 2004
..To apply in practice a series of validated indicators for preventable drug related morbidity (PDRM)...
- Views of older persons with multiple morbidities on competing outcomes and clinical decision-making
Terri R Fried
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
J Am Geriatr Soc 56:1839-44. 2008
- Preventable drug-related hospital admissions
Almut G Winterstein
Department of Pharmacy Health Care Administration, College of Pharmacy, University of Florida, Gainesville, FL 32610 0496, USA
Ann Pharmacother 36:1238-48. 2002
..To estimate the prevalence of preventable drug-related hospital admissions (PDRAs) and to explore if selected study characteristics affect prevalence estimates...
- The impact of unlicensed and off-label drug use on adverse drug reactions in paediatric patients
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Drug Saf 27:1059-67. 2004
..This study investigates, for the first time in a German patient population, the impact of unlicensed and off-label drug use on ADRs in paediatric patients...
- Finding multiple target optimal intervention in disease-related molecular network
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
Mol Syst Biol 4:228. 2008
..A number of promising MTOI solutions were found to be both effective and safer...
- Defining rewardable innovation in drug therapy
Jeffrey K Aronson
Department of Primary Health Care, University of Oxford, 23 38 Hythe Bridge Street, Oxford OX1 2ET, UK
Nat Rev Drug Discov 11:253-4. 2012
..Here, we propose a definition of innovation with respect to medicinal products, accompanied by a ranking of the importance of different types of innovativeness, with the aim of providing a basis for rewarding such innovation...
- Oral manifestations of drug therapy
Departments of Oral Medicine, Pathology, and Otolaryngology, University of Pittsburgh School of Dental Medicine, 3501 Terrace Street, G 137 Salk, Pittsburgh, PA 15261, USA
Dent Clin North Am 46:857-68. 2002
..The dental practitioner is often the primary health care provider who can recognize, diagnose, treat, and/or prevent these conditions...
- A pharmacist model of perceived responsibility for drug therapy outcomes
Lourdes G Planas
Department of Clinical and Administrative Sciences, College of Pharmacy, University of Oklahoma, P O Box 26901, Oklahoma City, OK 73190, USA
Soc Sci Med 60:2393-403. 2005
..to reduce drug-related morbidity and to optimize patient outcomes by identifying, resolving, and preventing drug therapy problems...
- Inappropriate medication prescribing for the elderly by office-based physicians
R R Aparasu
College of Pharmacy, South Dakota State University, Brookings 57007 USA
Ann Pharmacother 31:823-9. 1997
..To estimate the prevalence of inappropriate medications prescribed by office-based physicians for patients 65 years or older...
- Drug therapy in the elderly: improving quality and access
Steven R Simon
Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA, USA
Clin Pharmacol Ther 73:387-93. 2003
- Identifying systematic reviews of the adverse effects of health care interventions
Centre for Reviews and Dissemination CRD, University of York, York, YO10 5DD, UK
BMC Med Res Methodol 6:22. 2006
..In order to carry out a methodological research survey of systematic reviews of adverse effects we needed to retrieve a sample of systematic reviews in which the primary outcome is an adverse effect or effects...
- Pharmacogenetic screening for drug therapy: from single gene markers to decision making in the next generation sequencing era
Department of Clinical Pharmacology, University Medical Center, Gottingen, Germany
Pathology 44:166-80. 2012
..We discuss here the challenges associated with choosing the correct therapy for patients who present to their physicians with personal genome data...
- Pharmacokinetics and pharmacodynamic changes associated with aging and implications for drug therapy
Leah Church Sera
Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
Clin Geriatr Med 28:273-86. 2012
..Consideration of initial dose adjustment, along with frequent medication reconciliation and analysis of the medication list, are keys to providing optimal pharmaceutical care for elderly patients...
- Drug therapy in dental practice: nonopioid and opioid analgesics
Daniel E Becker
Sinclair Community College, Dayton, Ohio, USA
Anesth Prog 52:140-9. 2005
..The clinician can and should develop a variety of effective, safe analgesic regimens, based on estimates of anticipated pain intensity that use sound pharmacological principles...
- Clinical pharmacy, pharmaceutical care, and the quality of drug therapy
Charles D Hepler
Department of Pharmacy Health Care Administration, College of Pharmacy, University of Florida, Gainesville, FL 32610 0496, USA
Pharmacotherapy 24:1491-8. 2004
Because of concerns about patient safety and the quality of health care in America, in particular about drug therapy, pharmacists have unprecedented opportunities to increase their value and significance...
- Pharmacy data in epidemiological studies: an easy to obtain and reliable tool
Taco B M Monster
Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University Institute for Drug Exploration GUIDE, Groningen, The Netherlands
Pharmacoepidemiol Drug Saf 11:379-84. 2002
..However, most investigations on this subject studied selected populations or subsets. We studied the coverage of Dutch pharmacy data for our study cohort, and the agreement between the different sources...
- Does the addition of a pharmacist transition coordinator improve evidence-based medication management and health outcomes in older adults moving from the hospital to a long-term care facility? Results of a randomized, controlled trial
Flinders University Department of Rehabilitation and Aged Care, Repatriation General Hospital, Daw Park, South Australia
Am J Geriatr Pharmacother 2:257-64. 2004
..Poorly executed transfers of older patients from hospitals to long-term care facilities carry the risk of fragmentation of care, poor clinical outcomes, inappropriate use of emergency department services, and hospital readmission...
- Just what the doctor ordered. Review of the evidence of the impact of computerized physician order entry system on medication errors
Tatyana A Shamliyan
Division of Health Policy and Management, University of Minnesota School of Public Health, MMC 729, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Health Serv Res 43:32-53. 2008
..Of 252 identified in the search, 12 (4.8 percent) original investigations that compared rates of prescribing medication errors with handwritten and computerized physician orders were included...
- Comparison of drug adherence rates among patients with seven different medical conditions
Becky A Briesacher
Division of Geriatric Medicine, University of Massachusetts Medical School, Worcester, Massachusetts Meyers Primary Care Institute, Worcester, MA 01605, USA
Pharmacotherapy 28:437-43. 2008
..To compare drug adherence rates among patients with gout, hypercholesterolemia, hypertension, hypothyroidism, osteoporosis, seizure disorders, and type 2 diabetes mellitus by using a standardized approach...
- Optimizing drug therapy in patients with cardiovascular disease: the impact of pharmacist-managed pharmacotherapy clinics in a primary care setting
Department of Veterans Affairs Outpatient Clinic, Orlando, Florida, USA
Pharmacotherapy 22:738-47. 2002
- Pharmacogenetics: potential for individualized drug therapy through genetics
Julie A Johnson
Department of Pharmacy Practice, Department of Pharmaceutics and Department of Medicine, University of Florida, Box 100486, Gainesville, FL 32610 0486, USA
Trends Genet 19:660-6. 2003
- Molecular basis of P450 inhibition and activation: implications for drug development and drug therapy
G D Szklarz
Department of Basic Pharmaceutical Sciences, West Virginia University, USA
Drug Metab Dispos 26:1179-84. 1998
- Selling sickness: the pharmaceutical industry and disease mongering
Australian Financial Review, GPO Box 506, Sydney, 2201, Australia
BMJ 324:886-91. 2002
- Risk perception in drug therapy
J K Aronson
Br J Clin Pharmacol 62:135-7. 2006
- Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead
Daniel W Nebert
Division of Human Genetics, Department of Pediatrics and Molecular Developmental Biology, University of Cincinnati Medical Center, P O Box 670056, Cincinnati OH 45267 0056, USA
Eur J Pharmacol 500:267-80. 2004
..reviews on this topic have painted an overly optimistic picture-suggesting that the advent of individualized drug therapy used by the practicing physician is fast approaching...
- Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy
Department of Medical and Surgical Therapeutics, Division of Clinical Pharmacology, Medical School, University of Extremadura, 06071 Badajoz, Spain
Eur J Clin Pharmacol 66:755-74. 2010
..Third, the use of a pharmacogenetic test as a standard of care for drug therapy has to overcome significant scientific, economic, commercial, political and educational barriers, among others, ..
- The effects of radiotherapy and chemotherapy on female reproduction
Department of Obstetrics and Gynecology, Rabin Medical Center, Israel
Hum Reprod Update 7:535-43. 2001
..Increased knowledge of these mechanisms could help to identify potential effective inhibitors that can block the path of primordial follicles destruction and reduce ovarian failure rate...
- Use of cardiovascular drugs after acute myocardial infarction: a marked shift towards evidence-based drug therapy
Department of Pharmacotherapeutics, Faculty of Medicine, University of Oslo, N 0316 Oslo, Norway
Cardiovasc Drugs Ther 16:451-6. 2002
- Medication use by persons with chronic fatigue syndrome: results of a randomized telephone survey in Wichita, Kansas
James F Jones
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop A15, Atlanta, GA 30333, USA
Health Qual Life Outcomes 1:74. 2003
..The objective of this study was to describe utilization of medications and supplements by persons with CFS and non-fatigued individuals representative of the general population of Wichita, Kansas...
- Principles of drug therapy for the elderly patient
Department of Medicine, Sarver Heart Center, University of Arizona, Tucson, Ariz, USA
Mayo Clin Proc 78:1564-77. 2003
- Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly
Kenneth E Schmader
Veterans Affairs Medical Center, Durham, North Carolina, USA
Am J Med 116:394-401. 2004
..To determine if inpatient or outpatient geriatric evaluation and management, as compared with usual care, reduces adverse drug reactions and suboptimal prescribing in frail elderly patients...
- A prospective multicentre study of pharmacist initiated changes to drug therapy and patient management in acute care government funded hospitals
Michael J Dooley
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australian
Br J Clin Pharmacol 57:513-21. 2004
To determine the cost savings of pharmacist initiated changes to hospitalized patients' drug therapy or management in eight major acute care government funded teaching hospitals in Australia.
- [Drug utilization in adults: prevalence and individuals determinants]
Andrea D Bertoldi
Programa de Pós Graduação em Epidemiologia, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, RS, Brasil
Rev Saude Publica 38:228-38. 2004
..To study epidemiological patterns of drug utilization and its individual determinants and to classify drugs used into pharmacological groups...
- Aging biology and geriatric clinical pharmacology
Allan J McLean
Director, National Ageing Research Institute, P O Box 31, Parkville, VIC Australia
Pharmacol Rev 56:163-84. 2004
..Even so, therapeutic advances generally may convert healthy longevity from an asset of fortunate individuals into a general social benefit...
- The role of cost-effectiveness analysis in the era of pharmacogenomics
Christopher R Flowers
Pharmaceutical Outcomes Research and Policy Program, University of Washington Medical Center, Seattle, Washington, USA
Pharmacoeconomics 22:481-93. 2004
- Drug use patterns in young German women and association with mental disorders
Institute of Clinical Pharmacology, TU Dresden, Germany
Ann Pharmacother 38:1529-34. 2004
..There is a lack of data about drug use patterns in young women. Mental disorders may influence those drug use patterns...
- Assessing the benefit-harm balance at the bedside
Yoon Kong Loke
School of Medicine, Health Policy and Practice University of East Anglia, Norwich NR4 7TJ
BMJ 329:7-8. 2004
- Algorithms for optimizing drug therapy
Department of Clinical Neuroscience, Karolinska Institutet, St Erik s Eye Hospital S 112 82 Stockholm, Sweden
BMC Med Inform Decis Mak 4:10. 2004
b>Drug therapy has become increasingly efficient, with more drugs available for treatment of an ever-growing number of conditions...
- Inappropriate prescribing for elderly Americans in a large outpatient population
Lesley H Curtis
Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
Arch Intern Med 164:1621-5. 2004
..We sought to determine the extent of potentially inappropriate outpatient prescribing for elderly patients, as defined by the Beers revised list of drugs to be avoided in elderly populations...
- Can an algorithm for appropriate prescribing predict adverse drug events?
Kimberly J Rask
Department of Health Policy and Management, Rollins School of Public Health, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Manag Care 11:145-51. 2005
..To evaluate whether a medication-appropriateness algorithm applied to pharmacy claims data can identify ambulatory patients at risk for experiencing adverse drug events (ADEs) from those medications...
- Case reports of suspected adverse drug reactions--systematic literature survey of follow-up
Yoon Kong Loke
School of Medicine, Health Policy, and Practice, University of East Anglia, Norwich NR4 7TJ
BMJ 332:335-9. 2006
..To determine whether anecdotal reports of suspected adverse drug reactions are valuable early warning signals...
- An observational study of changes to long-term medication after admission to an intensive care unit
A J Campbell
Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
Anaesthesia 61:1087-92. 2006
..Twenty-eight were continued beyond hospital discharge, some without apparent ongoing indication. Reliable mechanisms to prevent prescription errors are required...
- Drug-related hospitalizations in a tertiary care internal medicine service of a Canadian hospital: a prospective study
Leslie Jo Samoy
Clinical Service Unit Pharmaceutical Sciences, Vancouver General Hospital, Vancouver, British Columbia, Canada
Pharmacotherapy 26:1578-86. 2006
..To determine the frequency, severity, preventability, and classification of adverse drug events resulting in hospitalization, and to identify any patient, prescriber, drug, and system factors associated with these events...
- [A population-based study on use of medication by the elderly in Greater Metropolitan Belo Horizonte, Minas Gerais, Brazil]
Antônio I de Loyola Filho
Núcleo de Estudos em Saúde Pública e Envelhecimento, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Brasil
Cad Saude Publica 22:2657-67. 2006
- 99mTc-HYNIC Annexin-V imaging of tumors and its relationship to response to radiotherapy and/or chemotherapy
Division of Medical Oncology, University Hospital Ghent, Ghent, Belgium
Q J Nucl Med Mol Imaging 51:182-8. 2007
..The aim of this study was to report on the relationship between preradiotherapy and prechemotherapy 99mTc-HYNIC Annexin-V tumor uptake values, reflecting ongoing apoptosis, and outcome to radiotherapy and/or chemotherapy...
- Individualized drug therapy
Ann K Daly
School of Clinical and Laboratory Sciences, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Curr Opin Drug Discov Devel 10:29-36. 2007
..The introduction of pharmacogenetic tests into routine healthcare requires both a demonstration of cost-effectiveness and the availability of appropriate accessible testing systems...
- Hypnotic taper with or without self-help treatment of insomnia: a randomized clinical trial
Departement de Psychologie, Universite du Quebec a Montreal, Montreal, Quebec, Canada
J Consult Clin Psychol 75:325-35. 2007
..The addition of a self-help treatment focusing on insomnia, a readily available and cost-effective alternative to individual psychotherapy, produced greater sleep improvement...
- Automated acquisition of disease drug knowledge from biomedical and clinical documents: an initial study
Elizabeth S Chen
Clinical Informatics Research and Development, Partners HealthCare System, 93 Worcester Street, PO Box 81902, Wellesley, MA 02481, USA
J Am Med Inform Assoc 15:87-98. 2008
..Explore the automated acquisition of knowledge in biomedical and clinical documents using text mining and statistical techniques to identify disease-drug associations...
- Oral drug therapy for multiple neglected tropical diseases: a systematic review
Department of Medicine, Hebrew Rehabilitation Center, Boston, Massachusetts 02131, USA
JAMA 298:1911-24. 2007
..Seven of the most prevalent diseases have existing oral drug treatments. Identifying treatments that are effective against more than 1 disease could facilitate efficient and inexpensive treatment...
- Clinical review: medication errors in critical care
Department of Critical Care Medicine, University of Calgary, Foothills Medical Centre, EG23A, 1403 29 Street NW, Calgary, AB, Canada
Crit Care 12:208. 2008
..The aim of this article is to provide a basic review of medication errors in the ICU, identify risk factors for medication errors, and suggest strategies to prevent errors and manage their consequences...
- Education in clinical pharmacology at the Rijeka School of Medicine, Croatia
V Vlahovic Palcevski
Department of Pharmacology, University of Rijeka, Rijeka School of Medicine, Croatia
Eur J Clin Pharmacol 54:685-9. 1998
..Education is the key to improved effectiveness and safety in drug therapy. Development of clinical pharmacology (CP) as an independent discipline at the Rijeka School of Medicine has ..
- What is the quality of drug therapy clinical practice guidelines in Canada?
I D Graham
Departments of Medicine and of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ont
CMAJ 165:157-63. 2001
..This study was designed to identify and describe guidelines in the database that make recommendations related to the use of drug therapy, and to assess their quality using a standardized guideline appraisal instrument.
- Genetic variations in human G protein-coupled receptors: implications for drug therapy
Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco CA 94143 0446, USA
AAPS PharmSci 3:E22. 2001
Numerous genes encode G protein-coupled receptors (GPCRs)-a main molecular target for drug therapy. Estimates indicate that the human genome contains approximately 600 GPCR genes...
- Geriatric drug therapy and healthcare utilization in the United kingdom
Department of Epidemiology, AstraZeneca R and D, S 431 83 Molndal, Sweden
Ann Pharmacother 36:797-803. 2002
To describe the use of prescription drug therapy, especially polypharmacy, in an elderly general population; to relate that use to age, gender, and different types of healthcare utilization; and to investigate the influence of selection ..
- Principles of drug therapy in older patients: rational drug prescribing
Rebecca J Beyth
Division of Health Services Research, Baylor College of Medicine, Houston Center for Quality of Care and Utilization Studies, Houston VAMC, Division of Health Services Research, Houston, TX 77030, USA
Clin Geriatr Med 18:577-92. 2002
..Careful, compassionate attention to these factors can have a profound effect on improving the quality of life, medication use, and the overall cost of health care in this vulnerable population...
- Frequency and predictors of drug therapy interruptions after hospital discharge under physician drug budgets in Germany
Pharmazeutische Biologie, Pharmazeutisches Institut, Universitat Tubingen, Germany
Int J Clin Pharmacol Ther 41:77-82. 2003
We sought to study how frequently prescription drug therapy at hospital discharge was discontinued or changed by general practitioners under physician drug budgets in Germany and explore reasons and predictors for such discontinuations.
- Collaborative drug therapy management by pharmacists--2003
Raymond W Hammond
2001 2002 ACCP Task Force on Collaborative Drug Therapy Management, USA
Pharmacotherapy 23:1210-25. 2003
..care community at large have come to better appreciate the growing complexity of providing effective and safe drug therapy in today's health care environment...
- Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy
Jean Louis Baneres
UMR CNRS 5074, Chimie Biomoléculaire et Interactions Biologiques, Faculte de Pharmacie, 15 Avenue Ch Flahault, 34093 Montpellier Cedex 05, France
J Biol Chem 280:20253-60. 2005
- Drug-drug interactions among recently hospitalised patients--frequent but mostly clinically insignificant
Clinic of Internal Medicine I, H S Bispebjerg Hospital, 2100, Copenhagen, Denmark
Eur J Clin Pharmacol 61:675-81. 2005
..The aim of the present study was to identify potential drug-drug interactions between drugs used by patients recently discharged from the hospital and, subsequently, to estimate the clinical implications of these interactions...
- Adherence to medication
General Medicine Division, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
N Engl J Med 353:487-97. 2005
- The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care
Jeffrey M Rothschild
Divisions of General Internal Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Crit Care Med 33:1694-700. 2005
..We sought to study the incidence and nature of adverse events and serious errors in the critical care setting...
- Factors associated with potentially inappropriate drug utilization in a sample of rural community-dwelling older adults
Susan J Blalock
School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599 7360, USA
Am J Geriatr Pharmacother 3:168-79. 2005
..The Beers criteria are often used to identify such medications. Past research has documented that use of Beers drugs is common among older adults...
- Implications of pharmacogenomics for drug development and clinical practice
Geoffrey S Ginsburg
Department of Medicine, School of Medicine, Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
Arch Intern Med 165:2331-6. 2005
..Although the potential of these technologies is driving change in the development of clinical sciences, it remains to be seen which health care systems level needs will be addressed...
- Impact of prescription-term deregulation with revised medical service fees on drug therapy management
Department of Pharmacy, Kagawa University Hospital, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
Yakugaku Zasshi 125:959-69. 2005
..There is a concern that the prescription-term deregulation could cause careless drug therapy management in order to extend the interval between patient hospital visits...
- Choice of delta: requirements and reality--results of a systematic review
Institute for Quality and Efficiency in Health Care, Cologne, Germany
Biom J 47:12-27; discussion 99-107. 2005
..Overall, it seems that a more global definition of 'irrelevance' might be warranted...
- A regulatory perspective on choice of margin and statistical inference issue in non-inferiority trials
H M James Hung
Division of Biometrics I, Office of Biostatistics, OPaSS, CDER, FDA, HFD 710, Room 5062, WOC2, 1451 Rockville Pike, Rockville, MD 20852, USA
Biom J 47:28-36; discussion 99-107. 2005
..The margin can be a fixed margin or a margin functionally defined. Between-trial differences always exist and need to be properly considered...
- Adverse drug reaction-related hospitalisations: a nationwide study in The Netherlands
Cornelis S van der Hooft
Pharmaco epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus University Medical Centre, Rotterdam, The Netherlands
Drug Saf 29:161-8. 2006
..The incidence of adverse drug reaction (ADR)-related hospitalisations has usually been assessed within hospitals. Because of the variability in results and methodology, it is difficult to extrapolate these results to a national level...
- Cancer therapy-associated CNS neuropathology: an update and review of the literature
Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Acta Neuropathol 111:197-212. 2006
..Therefore, it is critical to recognize the full spectrum of cancer therapy-associated neuropathology, the topic of the current review...
- Brief communication: Better ways to question patients about adverse medical events: a randomized, controlled trial
University of California and San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
Ann Intern Med 144:257-61. 2006
..There is no standard method of identifying adverse events in clinical trials...
- Reconciliation of medications
Nancy M Saufl
Preadmission Testing Center, Florida Hospital, Memorial Division, Ormond Beach, FL 32174, USA
J Perianesth Nurs 21:126-7. 2006
- Standard treatment and experimental targeted drug therapy for recurrent glioblastoma multiforme
Susan M Chang
Department of Neurological Surgery, University of California, San Francisco, California 94143 0350, USA
Neurosurg Focus 20:E4. 2006
..In this paper the authors outline standard therapies and review the emerging role of targeted drug therapy in the treatment of recurrent GBM.
- A meta-analysis of the association between adherence to drug therapy and mortality
Scot H Simpson
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2N8
BMJ 333:15. 2006
To evaluate the relation between adherence to drug therapy, including placebo, and mortality.
- Represcription after adverse drug reaction in the elderly: a descriptive study
Carolien M J van der Linden
Arch Intern Med 166:1666-7. 2006
- Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics
Daniel W Nebert
Division of Human Genetics, Department of Pediatrics and Molecular Developmental Biology, Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
Trends Pharmacol Sci 27:580-6. 2006
..by themselves, either transcriptomics or proteomics will be particularly helpful in achieving individualized drug therapy. However, recent advances in metabonomics are exciting and show promise...
- Hypoxia, drug therapy and toxicity
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
Pharmacol Ther 113:229-46. 2007
..This review will summarize our current understanding of hypoxia signaling as it applies to drug therapy and toxicity and describe how these processes can influence the HIF-mediated balance between adaptation and ..
- Interventions of hospital pharmacists in improving drug therapy in children: a systematic literature review
The School of Pharmacy, Centre for Paediatric Pharmacy Research, Institute of Child Health, University of London, Great Ormond Street Hospital for Children, London, England
Drug Saf 29:1031-47. 2006
..Age-specific changes in pharmacokinetics and pharmacodynamics further complicate drug therapy in children...