induced hypothermia

Summary

Summary: Abnormally low BODY TEMPERATURE intentionally induced in warm-blooded animals by artificial means.

Top Publications

  1. ncbi Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption
    Ryan K Bachtell
    Department of Behavioural Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, OR 97239, USA
    Eur J Neurosci 20:1613-23. 2004
  2. ncbi Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial
    Peter D Gluckman
    The Liggins Institute, University of Auckland, Auckland, New Zealand
    Lancet 365:663-70. 2005
  3. ncbi Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Division of Neonatal Perinatal Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    N Engl J Med 353:1574-84. 2005
  4. ncbi Moderate hypothermia to treat perinatal asphyxial encephalopathy
    Denis V Azzopardi
    Division of Clinical Sciences and Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, United Kingdom
    N Engl J Med 361:1349-58. 2009
  5. ncbi Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling
    M A De Georgia
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurology 63:312-7. 2004
  6. ncbi Intrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway
    Ma Qing
    German Heart Center Munich, Technical University, Munich, Germany
    Crit Care Med 31:2769-75. 2003
  7. ncbi Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia
    Stephen A Bernard
    Intensive Care Unit, Dandenong Hospital, Dandenong, Australia
    N Engl J Med 346:557-63. 2002
  8. ncbi Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 29:2461-6. 1998
  9. ncbi Endovascular cooling for moderate hypothermia in patients with acute stroke: first results of a novel approach
    D Georgiadis
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:2550-3. 2001
  10. ncbi A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild Hypothermia Study Group in Japan
    T Shiozaki
    Department of Traumatology, Osaka University Medical School, Kinki University School of Medicine, Japan
    J Neurosurg 94:50-4. 2001

Detail Information

Publications281 found, 100 shown here

  1. ncbi Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption
    Ryan K Bachtell
    Department of Behavioural Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, OR 97239, USA
    Eur J Neurosci 20:1613-23. 2004
    ..differences in the EW urocortin I system are correlated with ethanol-mediated behaviours such as ethanol-induced hypothermia and ethanol consumption...
  2. ncbi Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial
    Peter D Gluckman
    The Liggins Institute, University of Auckland, Auckland, New Zealand
    Lancet 365:663-70. 2005
    ..We did a multicentre randomised controlled trial to find out if delayed head cooling can improve neurodevelopmental outcome in babies with neonatal encephalopathy...
  3. ncbi Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
    Seetha Shankaran
    Division of Neonatal Perinatal Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
    N Engl J Med 353:1574-84. 2005
    ..Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain...
  4. ncbi Moderate hypothermia to treat perinatal asphyxial encephalopathy
    Denis V Azzopardi
    Division of Clinical Sciences and Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, United Kingdom
    N Engl J Med 361:1349-58. 2009
    ..Whether hypothermic therapy improves neurodevelopmental outcomes in newborn infants with asphyxial encephalopathy is uncertain...
  5. ncbi Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling
    M A De Georgia
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurology 63:312-7. 2004
    ..To report results of a randomized pilot clinical feasibility trial of endovascular cooling in patients with ischemic stroke...
  6. ncbi Intrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway
    Ma Qing
    German Heart Center Munich, Technical University, Munich, Germany
    Crit Care Med 31:2769-75. 2003
    ..CONCLUSION Our results show that hypothermia during cardiopulmonary bypass up-regulates interleukin-10 via STAT-3 activation, which in turn leads to the attenuation of tumor necrosis factor-alpha expression and to hepatic protection...
  7. ncbi Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia
    Stephen A Bernard
    Intensive Care Unit, Dandenong Hospital, Dandenong, Australia
    N Engl J Med 346:557-63. 2002
    ..In a randomized, controlled trial, we compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest...
  8. ncbi Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 29:2461-6. 1998
    ..Clinical studies on moderate hypothermia in the treatment of acute ischemic stroke patients are still lacking...
  9. ncbi Endovascular cooling for moderate hypothermia in patients with acute stroke: first results of a novel approach
    D Georgiadis
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:2550-3. 2001
    ..CONCLUSIONS: Induction and maintenance of hypothermia with an intravenous cooling device are feasible. The safety of this approach remains to be evaluated...
  10. ncbi A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild Hypothermia Study Group in Japan
    T Shiozaki
    Department of Traumatology, Osaka University Medical School, Kinki University School of Medicine, Japan
    J Neurosurg 94:50-4. 2001
    ..A prospective randomized controlled trial was conducted to determine whether mild hypothermia is essential in the treatment of severely head injured patients with low intracranial pressure (ICP)...
  11. ncbi Effects of hypothermia and hyperthermia on cytokine production by cultured human mononuclear phagocytes from adults and newborns
    K D Fairchild
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 20201, USA
    J Interferon Cytokine Res 20:1049-55. 2000
    ..Hypothermia, on the other hand, may worsen outcome in infections by delaying and prolonging cytokine production...
  12. ncbi Hemicraniectomy and moderate hypothermia in patients with severe ischemic stroke
    D Georgiadis
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:1584-8. 2002
    ....
  13. ncbi Neuroprotective effect of delayed moderate hypothermia after focal cerebral ischemia: an MRI study
    R Kollmar
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:1899-904. 2002
    ..We examined the influence of delayed hypothermia on secondary ischemic injury, MRI lesion size, and neurological outcome after transient focal cerebral ischemia in a rat model...
  14. ncbi General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
    J Cereb Blood Flow Metab 27:1879-94. 2007
    ....
  15. ncbi Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats: the effect of injury severity and brain temperature
    Elizabeth A Vitarbo
    Department of Neurological Surgery, The Neurotrauma Research Center, The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33101, USA
    Neurosurgery 55:416-24; discussion 424-5. 2004
    ..This study determined the regional and temporal profile of TNFalpha levels after moderate and severe TBI and assessed the effects of posttraumatic hypothermia or hyperthermia on this proinflammatory cytokine...
  16. ncbi Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia
    M R Battin
    Newborn Service, National Women s Hospital, Auckland, New Zealand
    Pediatrics 107:480-4. 2001
    ..To determine the neurodevelopmental outcome of infants treated with head cooling with systemic hypothermia after hypoxic-ischemic encephalopathy...
  17. ncbi Induced hypothermia for infants with hypoxic- ischemic encephalopathy using a servo-controlled fan: an exploratory pilot study
    Alan Horn
    Division of Neonatal Medicine, School of Child and Adolescent Health, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    Pediatrics 123:e1090-8. 2009
    ..The objective of this pilot study was to describe the use, efficacy, and physiologic impact of an inexpensive servo-controlled cooling fan blowing room-temperature air...
  18. ncbi Induced hypothermia for acute stroke
    Thomas M Hemmen
    Department of Neuroscience, University of California, San Diego, San Diego, CA 92103 8466, USA
    Stroke 38:794-9. 2007
    b>Induced hypothermia is one of the most promising neuroprotective therapies. Technological limitations and homeostatic mechanisms that maintain core body temperature have impeded the clinical use of hypothermia...
  19. ncbi Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy
    Alistair J Gunn
    Department of Physiology, University of Auckland, Auckland, New Zealand
    J Pediatr 152:55-8, 58.e1. 2008
    ..To evaluate whether therapeutic hypothermia alters the prognostic value of clinical grading of neonatal encephalopathy...
  20. ncbi Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia
    Tuomas Oksanen
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Finland
    Resuscitation 80:165-70. 2009
    ....
  21. ncbi Induced hypothermia and fever control for prevention and treatment of neurological injuries
    Kees H Polderman
    Department of Intensive Care, University Medical Center Utrecht, Utrecht, Netherlands
    Lancet 371:1955-69. 2008
    ..In particular, the rate of rewarming seems to be an important factor in establishing successful use of hypothermia in the treatment of neurological injuries...
  22. ncbi Mild hypothermia induced by a helmet device: a clinical feasibility study
    S Hachimi Idrissi
    Department of Critical Care Medicine and Cerebral Resuscitation Research Group, AZ VUB, Free University of Brussels, Laarbeeklaan, 101, B 1090, Brussels, Belgium
    Resuscitation 51:275-81. 2001
    ..CONCLUSIONS: Mild hypothermia induced by a helmet device was feasible, easy to perform, inexpensive and effective, with no increase in complications...
  23. ncbi Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis
    Xue Han Ning
    Division of Cardiology, Department of Pediatrics, University of Washington, Seattle 98195, USA
    J Appl Physiol (1985) 92:2200-7. 2002
    ..These data imply that hypothermia modifies signaling pathways for apoptosis and suggest possible mechanisms for hypothermia-induced myocardial protection...
  24. ncbi Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric stroke
    Stefan Schwarz
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:497-501. 2002
    ..The purpose of this study was to prospectively evaluate the effects of body position in patients with large supratentorial stroke...
  25. ncbi High-volume hemofiltration after out-of-hospital cardiac arrest: a randomized study
    Ivan Laurent
    Medical ICU, Cochin Teaching Hospital, Rene Descartes University, Paris, France
    J Am Coll Cardiol 46:432-7. 2005
    ..The study examined the effect of isovolumic high-volume hemofiltration (HF) alone or combined with mild hypothermia (HT) on survival after out-of-hospital cardiac arrest (OHCA) with initial ventricular fibrillation or asystole...
  26. ncbi The role of hypothermia in the management of severe brain injury: a meta-analysis
    Odette A Harris
    Department of Neurosurgery, Stanford University Medical Center, 300 Pasteur Dr, Edwards Bldg, Second Floor, Stanford, CA 94305, USA
    Arch Neurol 59:1077-83. 2002
    ..Hypothermia is utilized in the management of severe traumatic brain injury despite the lack of unequivocal evidence supporting its use. Because of its widespread use, the effects of hypothermia are a concern...
  27. ncbi Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarction
    Sharon L Hale
    The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
    Cardiovasc Res 59:715-22. 2003
    ..This study tests the effects of regional hypothermia, initiated late during ischemia and maintained for 2 h of reperfusion, on the no-reflow phenomenon...
  28. ncbi Buspirone and meperidine synergistically reduce the shivering threshold
    M Mokhtarani
    Department of Anesthesia, University of California, San Francisco, USA
    Anesth Analg 93:1233-9. 2001
    ..This combination may facilitate the induction of therapeutic hypothermia in stroke victims...
  29. ncbi Clinical aspects of induced hypothermia in full term neonates with perinatal asphyxia
    Floris Groenendaal
    Department of Neonatology, Perinatal Center, Wilhelmina Children s Hospital University Medical Center Utrecht, Utrecht, The Netherlands
    Early Hum Dev 85:73-6. 2009
    ..Further studies aiming at optimizing onset, duration, and depth of hypothermia in neonates are necessary. Combination of hypothermia with drugs may further improve neuroprotection in asphyxiated full term neonates...
  30. ncbi Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracellular adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemia
    Kenji Fujimoto
    Department of Critical Care and Emergency Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Pancreas 37:176-81. 2008
    ..To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats...
  31. ncbi The effects of mild induced hypothermia on the myocardium: a systematic review
    Fiona E Kelly
    Department of Anaesthesia and Intensive Care Medicine, Frenchay Hospital, Bristol, UK
    Anaesthesia 65:505-15. 2010
    Mild induced hypothermia improves neurological outcome and reduces mortality among initially comatose survivors of out-of-hospital cardiac arrest...
  32. ncbi Dexmedetomidine and meperidine additively reduce the shivering threshold in humans
    Anthony G Doufas
    Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
    Stroke 34:1218-23. 2003
    ..We tested the hypothesis that meperidine and dexmedetomidine synergistically reduce the shivering threshold without producing substantial sedation or respiratory depression...
  33. ncbi Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review
    Prakesh S Shah
    Department of Paediatrics, Mount Sinai Hospital, and University of Toronto, Ontario, M5G 1X5, Canada
    Arch Pediatr Adolesc Med 161:951-8. 2007
    ..0-33.5 degrees C] or mild [>or=33.6 degrees C])...
  34. ncbi Regional expression of constitutive and inducible transcription factors following transient focal ischemia in the neonatal rat: influence of hypothermia
    Nina G Pabello
    Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, Albany, NY 12208, USA
    Brain Res 1038:11-21. 2005
    ..Thus, focal ischemia in the P7 rat produces different distributions of Fos and pCREB than what has been observed in adult rats subjected to focal ischemia, and expression of these transcription factors can be altered by hypothermia...
  35. ncbi Long-term neurological outcome after cardiac arrest and therapeutic hypothermia
    Tobias Cronberg
    Department of Clinical Sciences, Lund Section for Neurology, Lund University, Sweden
    Resuscitation 80:1119-23. 2009
    ..To analyse the neurological status of survivors after cardiac arrest (CA) treated with hypothermia...
  36. ncbi Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases
    J Jiang
    Department of Neurosurgery, Chang Zheng Hospital, Shanghai Neurosurgical Institute, People s Republic of China
    J Neurosurg 93:546-9. 2000
    ..The goal of this study was to investigate the protective effects of long-term (3-14 days) mild hypothermia therapy (33-35 degrees C) on outcome in 87 patients with severe traumatic brain injury (TBI) (Glasgow Coma Scale score < or = 8)...
  37. ncbi Studies on fluid extravasation related to induced hypothermia during cardiopulmonary bypass in piglets
    J K Heltne
    Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway
    Acta Anaesthesiol Scand 45:720-8. 2001
    ..As no leakage of proteins could be demonstrated, based on stable values for albumin and protein masses throughout the experiments, the extravasated fluid contained mainly water and small solutes...
  38. ncbi Regional low-flow perfusion provides cerebral circulatory support during neonatal aortic arch reconstruction
    F A Pigula
    Department of Pediatric Cardiothoracic Surgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Thorac Cardiovasc Surg 119:331-9. 2000
    ....
  39. ncbi Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit
    Z L Lin
    Department of Neonatology, Yuying Children s Hospital of Wenzhou Medical College, Wenzhou, China
    J Perinatol 26:180-4. 2006
    ..The objective of this study was to determine the efficacy of mild hypothermia via selective head cooling as a neuroprotective therapy in term infants with perinatal asphyxia...
  40. pmc Cooling methods used in the treatment of exertional heat illness
    J E Smith
    Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK
    Br J Sports Med 39:503-7; discussion 507. 2005
    ..To review the different methods of reducing body core temperature in patients with exertional heatstroke...
  41. ncbi Rectal temperature reflects tympanic temperature during mild induced hypothermia in nonintubated subjects
    Richard M Zweifler
    University of South Alabama Stroke Center, Mobile, 36617, USA
    J Neurosurg Anesthesiol 16:232-5. 2004
    Mild induced hypothermia holds promise as an effective neuroprotective strategy following acute stroke and cardiac arrest...
  42. ncbi Hypothermia during reperfusion does not reduce myocardial infarct size in pigs
    Michael Maeng
    Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Brendstrupgaardsvej, 8200 Aarhus N, Denmark
    Basic Res Cardiol 101:61-8. 2006
    ..74 +/- 0.09; p = ns vs control for both comparisons). In conclusion, hypothermia during ischemia is strongly myocardioprotective while hypothermia during reperfusion does not reduce myocardial infarct size in human-sized pigs...
  43. ncbi Under-humidification and over-humidification during moderate induced hypothermia with usual devices
    Francois Lellouche
    INSERM U 651, Universite Paris XII, Service de Reanimation Medicale, AP HP, Hopital Henri Mondor, 51 Av du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Intensive Care Med 32:1014-21. 2006
    In mechanically ventilated patients with induced hypothermia, the efficacy of heat and moisture exchangers and heated humidifiers to adequately humidify the airway is poorly known...
  44. ncbi Moderate hypothermia in neonatal encephalopathy: efficacy outcomes
    Dorothea J Eicher
    Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pediatr Neurol 32:11-7. 2005
    ..019). Although these results need to be validated in a large clinical trial, this pilot trial provides important data for clinical trial design of hypothermia treatment in neonatal hypoxic-ischemic injury...
  45. ncbi Treatment and outcome in post-resuscitation care after out-of-hospital cardiac arrest when a modern therapeutic approach was introduced
    M Werling
    Division of Cardiology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Resuscitation 73:40-5. 2007
    ..At present, there are no clear guidelines specifying how they should be treated. The aim of this survey was to describe the outcome for initial survivors of out-of-hospital cardiac arrest when a more aggressive approach was applied...
  46. ncbi Mechanisms of hypothermic protection against ischemic liver injury in mice
    Atsushi Kato
    Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 282:G608-16. 2002
    ..These data suggest that hypothermia suppresses the hepatic inflammatory response through selective inhibition of JNK and AP-1...
  47. ncbi Cerebral resuscitation: state of the art, experimental approaches and clinical perspectives
    Erik Popp
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D 69120, Heidelberg, Germany
    Neurol Clin 24:73-87, vi. 2006
    ..Promising animal experimental data concerning the use of thrombolytic agents during cardiopulmonary resuscitation have led to a large European multicenter trial (TROICA trial) that will provide its data in 2006...
  48. ncbi Prolonged moderate hypothermia in massive hemispheric infarction: clinical experience
    Didier Milhaud
    Neurological Intensive Care Unit, Hopital Gui de Chauliac, CHU Montpellier, France
    J Neurosurg Anesthesiol 17:49-53. 2005
    ..Prolonged hypothermia with gamma-hydroxybutyrate can be used to treat MaCI patients, with a fairly good clinical outcome for survivors...
  49. ncbi Mild hypothermia mitigates post-ischemic neuronal death following focal cerebral ischemia in rat brain: immunohistochemical study of Fas, caspase-3 and TUNEL
    P B Phanithi
    Department of Pathology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Neuropathology 20:273-82. 2000
    ..Further, DNA fragmentation was confirmed by size fractionation in agarose gel. These findings demonstrate a positive relation between the expression of Fas, caspase-3 and TUNEL-positive cells...
  50. ncbi Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke
    D W Krieger
    Cerebrovascular Center, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Stroke 32:1847-54. 2001
    ..Hypothermia is effective in improving outcome in experimental models of brain infarction. We studied the feasibility and safety of hypothermia in patients with acute ischemic stroke treated with thrombolysis...
  51. ncbi Induced hypothermia in comatose survivors of asphyxia: a case series of 14 consecutive cases
    S Baldursdottir
    Department of Anaesthesia and Intensive Care Medicine, Landspitali University Hospital, Reykjavik, Iceland
    Acta Anaesthesiol Scand 54:821-6. 2010
    b>Induced hypothermia is widely used for comatose survivors of cardiac arrest. Other causes of hypoxic brain injury carry a poor prognosis when treated using traditional methods...
  52. ncbi Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats
    Seema Briyal
    Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA
    Eur J Pharmacol 644:73-9. 2010
    ..The results demonstrate that a combination of acetaminophen and BQ123 is more effective in reducing the neuronal damage following cerebral ischemia, and this combination may be worth investigating in stroke patients...
  53. ncbi Induced hypothermia and determination of neurological outcome after CPR in ICUs in the Netherlands: results of a survey
    Aline Bouwes
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Resuscitation 81:393-7. 2010
    ..The aim of the present survey was to evaluate self-reported implementation of hypothermia after CPR and the methods used to predict neurological outcome at Intensive Care Units (ICUs) in the Netherlands...
  54. ncbi Preliminary clinical outcome study of mild resuscitative hypothermia after out-of-hospital cardiopulmonary arrest
    Y Yanagawa
    Department of Traumatology and Critical Care Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
    Resuscitation 39:61-6. 1998
    ..Our study, although preliminary, suggests that MH might confer improved outcome, as has been shown in animal models, after CPA. This treatment is associated with an increase in pneumonic complications...
  55. ncbi Effects of induced hypothermia after soft-tissue injury
    Andreas Wladis
    Department of Surgery, Soder Hospital, Karolinska Institute, 11883 Stockholm, Sweden
    Arch Orthop Trauma Surg 124:243-9. 2004
    ..For this purpose, we studied the acute effects of hypothermia induced after infliction of a standardized soft-tissue injury...
  56. ncbi Induced hypothermia attenuates the acute lung injury in hemorrhagic shock
    Kyuseok Kim
    Department of Emergency Medicine, Seoul National University College of Medicine, South Korea
    J Trauma 68:373-81. 2010
    ..However, the effect of induced HT on acute lung injury (ALI) in HS has not been investigated. We sought to determine the effects of HT on ALI in HS...
  57. ncbi Aminoglycoside pharmacokinetic parameters in neurocritical care patients undergoing induced hypothermia
    Jessica M Mercer
    Department of Pharmacy Services, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Pharmacotherapy 30:654-60. 2010
    To determine the effects of mild-to-moderate induced hypothermia-a neuroprotectant and/or therapeutic strategy for the management of intracranial hypertension in neurologically injured patients-on the pharmacokinetics of aminoglycoside ..
  58. ncbi Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry
    Shahid Shafi
    Department of Surgery, Division of Burn, Trauma and Surgical Critical Care, University of Texas Southwestern Medical School, Dallas, Texas 75390 9158, USA
    J Trauma 59:1081-5. 2005
    Successful application of induced hypothermia (HT) after stroke and cardiac arrest has led to a resurgence of interest in its potential protective effects in trauma patients...
  59. ncbi The use of induced hypothermia after cardiac arrest: a survey of Canadian emergency physicians
    Joel Kennedy
    Department of Emergency Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    CJEM 10:125-30. 2008
    ..Despite this, other studies have found that few resuscitation physicians have used hypothermia in clinical practice. The objective of this study was to characterize the use of induced hypothermia by Canadian emergency physicians.
  60. ncbi Induced hypothermia by central venous infusion: saline ice slurry versus chilled saline
    Terry L Vanden Hoek
    University of Chicago, Section of Emergency Medicine, Chicago, IL, USA
    Crit Care Med 32:S425-31. 2004
    ..an equal volume of chilled saline. We hypothesized that slurry would achieve core hypothermia (32-34 degrees C) more consistently and at a faster rate...
  61. ncbi Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210
    Ronen R Leker
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
    Stroke 34:2000-6. 2003
    ..Therefore, we sought to examine whether the synthetic CB1 agonist HU-210 is capable of reducing ischemic damage and to determine the mechanisms responsible for such protection...
  62. ncbi Renal hypothermia achieved by retrograde intracavitary saline perfusion
    Jaime Landman
    Division of Urology, Washington University School of Medicine, St Louis, Missouri, USA
    J Endourol 16:445-9. 2002
    ..We evaluated the utility of a newly developed ureteral access system for circulating ice-cold saline...
  63. ncbi Keeping a cool head: How to induce and maintain hypothermia
    Kees H Polderman
    Crit Care Med 32:2558-60. 2004
  64. ncbi Induced hypothermia in acute ischemic stroke
    Marc A Lazzaro
    Rush University Medical Center, Department of Neurological Sciences, 1725 W Harrison Street, Suite 1121, Chicago, IL 60612, USA
    Expert Opin Investig Drugs 17:1161-74. 2008
    b>Induced hypothermia is a promising neuroprotective treatment for acute ischemic stroke. Data from both global and focal ischemia animal models have been encouraging...
  65. ncbi Admission hypothermia and outcome after major trauma
    Henry E Wang
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Crit Care Med 33:1296-301. 2005
    ..The goal of this study was to evaluate the independent association between admission hypothermia and mortality after major trauma, with adjustment for clinical confounders...
  66. ncbi Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2
    Iori Sakakibara
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan
    Cell Metab 9:191-202. 2009
    ..Our findings demonstrate that activation of acetate by AceCS2 plays a pivotal role in thermogenesis, especially under low-glucose or ketogenic conditions, and is crucially required for survival...
  67. ncbi Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline
    Francis Kim
    Department of Medicine, Box 359748, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Circulation 115:3064-70. 2007
    ..The aims of the present pilot study were to assess the feasibility, safety, and effectiveness of in-field cooling...
  68. ncbi Mechanisms of action, physiological effects, and complications of hypothermia
    Kees H Polderman
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Crit Care Med 37:S186-202. 2009
    ..In recent years important insights have been gained into the mechanisms underlying hypothermia's protective effects; in addition, physiological and pathophysiological changes associated with cooling have become better understood...
  69. ncbi Processed aconite root prevents cold-stress-induced hypothermia and immuno-suppression in mice
    Toshiaki Makino
    Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Nagoya City University, Japan
    Biol Pharm Bull 32:1741-8. 2009
    ....
  70. ncbi Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global ischemia in rats
    W D Dietrich
    Department of Neurology, The Miami Project to Cure Paralysis, Miami, Florida, 33101, USA
    Exp Neurol 158:444-50. 1999
    ..In postinjury settings where restricted durations of mild hypothermia can be induced, anti-inflammatory treatments, including IL-10, may promote chronic neuroprotection...
  71. ncbi Noninvasive selective brain cooling by head and neck cooling is protective in severe traumatic brain injury
    Wusi Qiu
    BRAIN Center, Department of Neurosurgery, Second Affiliated Hospital, Zhejiang University, School of Medicine, 88 Jiefang Road, Hangzhou 310009, China
    J Clin Neurosci 13:995-1000. 2006
    ..In conclusion, the noninvasive SBC described here is a safe method of administering therapeutic hypothermia, which can reduce ICP and improve prognosis without severe complications in patients with severe TBI...
  72. ncbi Hypothermia treatment for traumatic brain injury: a systematic review and meta-analysis
    Kim Peterson
    Oregon Evidence Based Practice Center, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurotrauma 25:62-71. 2008
    ..Accordingly, the BTF/AANS guidelines task force has issued a Level III recommendation for optional and cautious use of hypothermia for adults with TBI...
  73. ncbi Induced hypothermia after out-of-hospital cardiac arrest: one hospital's experience
    Ann M Whitfield
    Intensive Care Unit, Box Hill Hospital, Melbourne, Vic
    Crit Care Resusc 11:97-100. 2009
    ..We conducted a retrospective audit to assess whether induced hypothermia had been successfully incorporated into routine care at our hospital, and whether this improved patient ..
  74. ncbi Intra-arrest cooling improves outcomes in a murine cardiac arrest model
    Benjamin S Abella
    Emergency Resuscitation Center, Section of Emergency Medicine, The University of Chicago, Chicago, Ill 60637, USA
    Circulation 109:2786-91. 2004
    ..We sought to determine whether cooling during cardiac arrest before ROSC (ie, "intra-arrest" hypothermia) has survival benefit over more delayed post-ROSC cooling, using a murine cardiac arrest model...
  75. ncbi Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation
    J P Nolan
    Resuscitation Council of Southern Africa
    Circulation 108:118-21. 2003
  76. ncbi Feasibility and safety of moderate hypothermia after massive hemispheric infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Germany
    Stroke 32:2033-5. 2001
    ..This multicenter study was performed to evaluate (1) the safety and feasibility of moderate hypothermia and (2) its potential to reduce intracranial hypertension in acute stroke patients...
  77. ncbi Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia
    Malin Rundgren
    Department of Anaesthesia and Intensive Care, Lund University Hospital, Sweden
    Resuscitation 80:784-9. 2009
    ..To assess the prognostic value of repetitive serum samples of neuron specific enolase (NSE) and S-100B in cardiac arrest patients treated with hypothermia...
  78. ncbi Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest
    Raina M Merchant
    Section of Emergency Medicine, University of Chicago, Chicago, IL, USA
    Crit Care Med 34:1935-40. 2006
    ..We sought to evaluate current physician use of therapeutic hypothermia after cardiac arrest, to ascertain reasons for nonadoption of this treatment, and to determine current cooling techniques employed...
  79. ncbi Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size
    C M Maier
    Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, California 94305, USA
    J Neurosurg 94:90-6. 2001
    ..These studies lend further support to the use of mild hypothermia in the treatment of stroke...
  80. ncbi Epsilon PKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model
    Takayoshi Shimohata
    Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Dr R200, Stanford, CA 94305 5327, USA
    Stroke 38:375-80. 2007
    ..We studied epsilonPKC activation (by its localization and proteolysis) in a rodent stroke model and correlated the effects of hypothermia with epsilonPKC activity after cerebral ischemia...
  81. ncbi Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injury
    Ji Yao Jiang
    Department of Neurosurgery, Renji Hospital, Shanghai Second Medical University, Shanghai, People s Republic of China
    J Cereb Blood Flow Metab 26:771-6. 2006
    ..Our data suggest that 5 days of long-term cooling is more efficacious than 2 days of short-term cooling when mild hypothermia is used to control refractory intracranial hypertension in patients with severe traumatic brain injury...
  82. doi Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial
    Nicola J Robertson
    Lancet 372:801-3. 2008
  83. ncbi Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage
    George Lotocki
    Department of Neurological Surgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA
    Eur J Neurosci 24:2283-90. 2006
    ..Thus, hypothermia mediates TNFR1 responses via early activation of the JNK signaling pathway and caspase-3, leading to endogenous neuroprotective events...
  84. ncbi Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs
    Ala Nozari
    Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 57:1266-75. 2004
    ..This study is designed to better mimic the clinical scenario of an exsanguinating trauma victim, for whom suspended animation may buy time for resuscitative surgery and delayed resuscitation...
  85. ncbi Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brain
    Pierre Gressens
    INSERM, U676, Paris, France
    Brain Pathol 18:10-20. 2008
    ..Longer survival studies are necessary to verify the safety of hypothermia in the developing brain...
  86. ncbi Antegrade selective cerebral perfusion in thoracic aorta surgery: safety of moderate hypothermia
    Davide Pacini
    Department of Cardiac Surgery, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Eur J Cardiothorac Surg 31:618-22. 2007
    ..The study analyzed the outcomes of aortic surgery using ASCP at different degree of systemic hypothermia...
  87. ncbi Rapid and selective cerebral hypothermia achieved using a cooling helmet
    Huan Wang
    Illinois Neurological Institute, St Francis Medical Center, University of Illinois College of Medicine at Peoria, Illinois 61656, USA
    J Neurosurg 100:272-7. 2004
    ..and H.W.) have developed a cooling helmet by using National Aeronautics and Space Administration spinoff technology. In this study its effectiveness in lowering brain temperature in patients with severe stroke or head injury is examined...
  88. ncbi Application of therapeutic hypothermia in the intensive care unit. Opportunities and pitfalls of a promising treatment modality--Part 2: Practical aspects and side effects
    Kees H Polderman
    Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Intensive Care Med 30:757-69. 2004
    b>Induced hypothermia can be used to protect the brain from post-ischemic and traumatic neurological injury. Potential clinical applications and the available evidence are discussed in a separate paper...
  89. ncbi Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in rats
    Li Xia Lou
    Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing, China
    Clin Exp Pharmacol Physiol 35:223-8. 2008
    ..4. In conclusion, a low concentration of H(2)S may be a new pharmacological tool for induced hypothermia to prevent severe stress-induced diseases and multifarious trauma in the clinical setting.
  90. ncbi Arch repair with unilateral antegrade cerebral perfusion
    Seref A Kucuker
    Kardiyovasküler Cerrahi Kliniği, Turkiye Yuksek Ihtisas Hastanesi, Sihhiye, Ankara 06100, Turkey
    Eur J Cardiothorac Surg 27:638-43. 2005
    ..This study demonstrates the clinical results of aortic arch repair with unilateral cerebral perfusion via the right brachial artery...
  91. ncbi Long-term effects of hypothermia on neuronal cell death and the concentration of apoptotic proteins after incomplete cerebral ischemia and reperfusion in rats
    E Eberspächer
    Klinik für Anesthesiologie, Technische Universitat Munchen, Munich, Germany
    Acta Anaesthesiol Scand 49:477-87. 2005
    ..The present study investigates the long-term effects of postischemic hypothermia on neuronal cell damage and concentration changes of apoptotic proteins after cerebral ischemia...
  92. ncbi Cold-induced fluid extravasation during cardiopulmonary bypass in piglets can be counteracted by use of iso-oncotic prime
    Marit Farstad
    Department of Anesthesia and Intensive Care, University of Bergen, Haukeland University Hospital, Bergen, Norway
    J Thorac Cardiovasc Surg 130:287-94. 2005
    ..This study aimed to compare whether iso-oncotic priming solutions, in contrast to crystalloids, could reduce the cold-induced fluid extravasation during cardiopulmonary bypass in piglets...
  93. ncbi Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis
    Michael Holzer
    Department of Emergency Medicine, General Hospital Vienna, Medical University of Vienna, Vienna, Austria
    Crit Care Med 33:414-8. 2005
    Only a few patients survive cardiac arrest with favorable neurologic recovery. Our objective was to assess whether induced hypothermia improves neurologic recovery in survivors of primary cardiac arrest.
  94. ncbi The evolution of serum astroglial S-100 beta protein in patients with cardiac arrest treated with mild hypothermia
    Said Hachimi-Idrissi
    Cerebral Resuscitation Research Group, Department of Critical Care Medicine, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Resuscitation 64:187-92. 2005
    ..To study the effects of mild hypothermia on the 24h concentration of serum astroglial of S-100 beta protein in patients who survived cardiac arrest (CA)...
  95. ncbi Cold infusions alone are effective for induction of therapeutic hypothermia but do not keep patients cool after cardiac arrest
    Andreas Kliegel
    Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18 20 6D, 1090 Vienna, Austria
    Resuscitation 73:46-53. 2007
    ..This study investigates if hypothermia can be induced and maintained by repetitive infusions of cold fluids and muscle relaxants...
  96. ncbi Hypothermia: a neuroprotective therapy for neonatal hypoxic-ischemic encephalopathy
    Lillian R Blackmon
    Division of Neonatology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pediatrics 117:942-8. 2006
  97. ncbi Development and testing of portable pump for the induction of profound hypothermia in a Swine model of lethal vascular injuries
    Hasan B Alam
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    J Trauma 61:1321-9. 2006
    ..In this experiment, a portable prototype pump was tested and its performance was compared with the regular roller pump in a swine model of lethal vascular injuries...
  98. ncbi Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB)
    Midori A Yenari
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, United States
    Neurochem Int 49:164-9. 2006
    ..These data suggest that the protective effect of hypothermia on cerebral injury is, in part, related to NFkappaB inhibition due to decreased activity of IKK...
  99. ncbi Brain cooling causes attenuation of cerebral oxidative stress, systemic inflammation, activated coagulation, and tissue ischemia/injury during heatstroke
    Shu Fen Hsu
    Institute of Physiology, National Yang Ming University School of Medicine, Taipei, Taiwan 112
    Shock 26:210-20. 2006
    ....
  100. ncbi Near-drowning treated with therapeutic hypothermia
    Jonathan P Williamson
    Respiratory and Critical Care Medicine, Manly District Hospital, Darcy Road, Manly, Sydney, NSW 2095, Australia
    Med J Aust 181:500-1. 2004
  101. ncbi Effects of mild induced hypothermia during experimental sepsis
    Erwan L'Her
    Medical Intensive Care Unit, University Hospital, Brest Cedex, France
    Crit Care Med 34:2621-3. 2006
    ..We experimentally investigated whether postconditioning temperature modifications influence survival duration during experimental sepsis...

Research Grants62

  1. Hypothermia and Gene Expression After Cardiac Arrest
    Clifton Callaway; Fiscal Year: 2005
    ..BDNF activation as well as the time window during which induction of hypothermia is beneficial suggest that induced hypothermia may affect new gene expression via these signaling systems...
  2. Regulation of Hepatic Uptake of Endogenous Signaling Molecules and Xenobiotics
    Ivan Csanaky; Fiscal Year: 2013
    ..maintaining their body temperature during surgical experiments, but are protected from lipopolysaccharide-induced hypothermia and hyperalgesia...
  3. Consequences of Cardiac Arrest: Brain Injury
    NITISH VYOMESH THAKOR; Fiscal Year: 2013
    ..Aim 2: We will study the mechanism by which induced hypothermia results in enhanced neurophysiologic recovery...
  4. Stroke Treatment by Chemically-Induced Hypothermia
    Shan Ping Yu; Fiscal Year: 2012
    ..Rather, we aim to demonstrate the feasibility of the chemical-induced hypothermia therapy and move to more systematic preclinical examinations of a Phase II investigation...
  5. Brain Monitoring and Therapeutic Hypothermia after Cardiac Arrest
    Xiaofeng Jia; Fiscal Year: 2013
    ..Among survivors of cardiac arrest (CA), brain injury is the biggest impediment to functional recovery. Induced hypothermia is currently the only form of therapy that improves both survival and neurological outcome for CA survivors...
  6. Effects of Hibernation on Hemostasis in 13-lined Ground Squirrels
    Scott T Cooper; Fiscal Year: 2012
    ..to prevent DVT, store human platelets in the cold, and regulate blood coagulation in cases of accidental or induced hypothermia. PUBLIC HEALTH RELEVANCE: This research may lead to medical advances to prevent blood clots, store human ..
  7. Mild Hypothermia for Resuscitated Out-of-Hospital Cardiac Arrest Patients
    Francis Kim; Fiscal Year: 2012
    ..Despite this evidence, induced hypothermia is not widely used, and its efficacy in patients with other initial rhythms is largely unstudied...
  8. Rapid Induction of Therapeutic Hypothermia
    Harikrishna Tandri; Fiscal Year: 2013
    ..In Phase II, we will develop a clinical-grade device and perform additional pig studies to confirm that the induced hypothermia is safe, effective and is associated with improved outcome of resuscitation and short term neurologic ..
  9. MOLECULAR BASIS FOR ETHANOL-INDUCED HYPOTHYROIDISM
    Robert Zoeller; Fiscal Year: 1993
    ..Alcohol-induced hypothermia in rodents has been widely used as a model system to study :he effects of acute and chronic ethanol; ..
  10. EXERCISE--EFFECTS ON ETOH IMPAIRMENT OF BEHAVIOR IN MICE
    SANDRA MOLLENAUER; Fiscal Year: 1993
    ..4 g/kg EtOH (20% w/v, IP), and also causes significant resistance to EtOH- induced hypothermia and Loss of Righting response (LORR) after 3.8 g/kg EtOH (20% w/v, IP)...
  11. Anticonvulsants for hypothermic neuroprotection in neonatal ischemic brain injury
    Faye Silverstein; Fiscal Year: 2009
    ..PAR-06-189, is to identify clinically feasible interventions that increase the neuroprotective efficacy of induced hypothermia after neonatal hypoxic-ischemic brain injury...
  12. Adrenergic Receptors During Periadolescent Development
    David Bylund; Fiscal Year: 2005
    ..abstract_text> ..
  13. Determinants of Tolerance to Nitrous Oxide Hypothermia
    Karl Kaiyala; Fiscal Year: 2004
    ..an R21 proposal to investigate the physiological mechanisms of tolerance development to nitrous oxide (N2O)-induced hypothermia. Influential theories of drug tolerance contend that CNS-mediated drug-opposing responses underlie the ..
  14. ETHANOL AND THE NEUROBIOLOGY OF TEMPERATURE REGULATION
    LARRY CRAWSHAW; Fiscal Year: 1990
    ..first part will be utilized in experiments designed to elucidate the central nervous mechanism of ethanol-induced hypothermia. In mice, the site of hypothalamic thermosensitivity will be accurately localized, and the responsiveness ..
  15. INDIVIDUAL DIFFERENCES AND ADDICTIVE VULNERABILITY
    Douglas Ramsay; Fiscal Year: 2000
    ..animals that are 1) initially insensitive to N2O induced-hypothermia, 2) initially sensitive to N2O-induced hypothermia but develop acute tolerance during the 4-hour administration, and 3) initially sensitive to N2O-induced ..
  16. Neuroadaptive Substrates for Nitrous Oxide Tolerance
    Karl Kaiyala; Fiscal Year: 2006
    ..However, preventing ethanol-induced hypothermia by elevating ambient temperature prevents development of chronic tolerance despite repeated drug ..
  17. Urocortin, Dorsal Raphe & Ethanol-induced Hypothermia
    VICTORIA TUREK; Fiscal Year: 2005
    ..identify the role that the urocortinergic projections from the alcohol-responsive EWto the DRN have in EtOH-induced hypothermia. The specific aims of the proposed studies are: 1) To determine what the differences are in the extent of ..
  18. ONTOGENY OF ETHANOL RESPONSIVITY
    Linda Spear; Fiscal Year: 1999
    ..ontogeny of acute ethanol sensitivity using a variety of response measures, including assessment of ethanol-induced hypothermia and suppression of startle as well as ethanol-induced alterations in locomotion and in swim speed; dose-..
  19. Juvenile alcohol exposure: Neurobehavioral consequences
    Ratna Sircar; Fiscal Year: 2005
    ..Adolescent rats exhibit more tolerance to alcohol-induced hypothermia, and greater impairments in spatial memory than adult rats...
  20. A MODEL OF FAS: GENERALIZABILITY AND MECHANISMS
    Carrie Randall; Fiscal Year: 1990
    ..will investigate the effects of aspirin pretreatment on alcohol-induced corticosterone levels, alcohol-induced hypothermia, and alcohol-induced stimulation of prostaglandins (PGE) in morse embryos...
  21. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  22. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. PATHOPHYSIOLOGY OF THROMBOEMBOLIC STROKE
    W Dietrich; Fiscal Year: 2003
    ..Neuroprotective strategies that may be given to patients with stroke risk factors to prevent the initiation of stroke will be tested. ..
  24. 23rd - 27th Annual National Neurotrauma Symposium
    W Dietrich; Fiscal Year: 2005
    ..In addition, there are two sessions for open communications as well as a panel discussions led by Women in Neurotrauma Research. Specific information regarding the organization of future meetings is also discussed. ..
  25. Enhancing Recovery after Neonatal Stroke
    John Barks; Fiscal Year: 2008
    ..Together these experiments will provide insights into the mechanisms that mediate and modulate functional recovery after neonatal stroke. [unreadable] [unreadable]..
  26. IKKBeta Mediated Impairment of Endothelial Nitric Oxide Production
    Francis Kim; Fiscal Year: 2010
    ..Aim 3. To determine whether the Toll Like Receptor pathway is necessary for endothelial activation of IKKbeta during the development of vascular insulin resistance. ..
  27. INSULIN RECEPTOR SUBSTRATE -1 AND FLUID SHEAR STRESS
    Francis Kim; Fiscal Year: 2005
    ..To further characterize this potential link between insulin and NO signaling. Specific Aim 3: Characterize FSS dependent signaling elements which associate with IRS-1...
  28. PAF IN PERINATAL CEREBRAL HYPOXIC/ISCHEMIC INJURY
    John Barks; Fiscal Year: 2002
    ..Morphometry and neurobehavioral testing are the primary indices that will be used to evaluate the stability of the neuroprotective efficacy of neonatal post-hypoxic-ischemic PAFF antagonist treatment, as rats reach maturity. ..
  29. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
  30. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
    ..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
  31. Normobaric Hyperoxia in Acute Ischemic Stroke
    Aneesh B Singhal; Fiscal Year: 2010
    ..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
  32. Cerebral Hemorrhage Model: Mechanisms and Treatments
    Kenneth Wagner; Fiscal Year: 2005
    ..abstract_text> ..
  33. NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
    Michael Dae; Fiscal Year: 2003
    ..These studies may provide a more comprehensive understanding of the interaction of the sympathetic nervous system and arrhythmogenesis. ..
  34. BRAIN ISCHEMIA AND MAP KINASE ACTIVATION
    Clifton Callaway; Fiscal Year: 2003
    ..The conduct of this project will provide extensive opportunities for collaboration with other basic scientists at the University of Pittsburgh, and promote the candidate's growth as an independent researcher. ..
  35. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  36. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  37. NEONATAL ENCEPHALOPATHY TREATED BY MODERATE HYPOTHERMIA
    Dorothea Jenkins; Fiscal Year: 2001
    ..abstract_text> ..
  38. Safety of N-acetylcysteine in Maternal Chorioamnionitis
    Dorothea Jenkins; Fiscal Year: 2009
    ....
  39. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..We plan to use clinically relevant large animal models to test the therapeutic application of induced hypothermia following exsanguinating shock...
  40. Drug discrimination and THC withdrawal in monkeys
    LANCE MCMAHON; Fiscal Year: 2005
    ..abstract_text> ..
  41. Nitrous Oxide and Wound Infections
    Ozan Akca; Fiscal Year: 2006
    ..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..
  42. Hypothermia for Pediatric Cardiac Arrest Planning Grant
    Frank Moler; Fiscal Year: 2004
    ..The CDMCC will make operational all data and analysis related tasks of this application, and assure all study sites are compliant with regulations concerning data security and confidentiality. ..
  43. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2001
    ..Since the cost of oxygen is trivial and the risks of oxygen administration are low, clinicians will easily be able to implement this treatment once we have demonstrated its benefits. ..
  44. Planning Hypothermia Trial for Pediatric Cardiac Arrest
    Frank Moler; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  45. Anesthetics, GABA and the Injured Brain
    David Warner; Fiscal Year: 2006
    ..We believe that GABAAergic pharmacologic properties of volatile anesthetics known to be critical for anesthesia are the same properties that confer cerebral protection. ..
  46. SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURY
    Martin Marsala; Fiscal Year: 2001
    ..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
  47. HEADGEAR MONITORING FOR ORTHODONTICS
    Douglas Ramsay; Fiscal Year: 2002
    ..Feedback on compliance will be readily available to patients, parents, and orthodontists. Improving compliance with headgear wear may have clinically beneficial consequences. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  48. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  49. PRESERVATION OF LIVER SLICES BY VITRIFICATION
    Michael Taylor; Fiscal Year: 2005
    ..The molecular ice control formulations which provide the highest tissue viability and least interstitial ice formation will be tested in larger animal and human PCLS tissues in a sub-sequent Phase II SBIR proposal. ..
  50. Pancreas Transporter Development and Validation
    Michael Taylor; Fiscal Year: 2006
    ..This research program is supported by collaboration with three major clinical centers interested in validation of this perfusion technology for their future use. [unreadable] [unreadable]..
  51. EXCITOTOXICITY IN CIRCULATORY ARREST--BRAIN INJURY
    William Baumgartner; Fiscal Year: 2007
    ....
  52. Nitrous Oxide, Individual Differences, and Conditioning
    Douglas Ramsay; Fiscal Year: 2007
    ..individual differences in the physiological mechanisms mediating tolerance to nitrous oxide (N20)-induced hypothermia. Drug tolerance, dependence and withdrawal are thought to be manifestations of a common underlying "..
  53. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2007
    ..The research team consists of respected investigators skilled in assessing NICU noise, evaluating infant responses, and performing randomized trials addressing important short and long term outcomes of ELBW infants. ..
  54. Role of Endocannabinoid Signaling in Alcoholism
    BALAPAL BASAVARAJAPPA; Fiscal Year: 2007
    ..The better understanding of these mechanisms will yield new drug therapies with potential in treatment of alcoholism. ..
  55. Genetic Defects of the Mammalian Circadian clock and Pre
    Cheng Lee; Fiscal Year: 2007
    ..In this proposal, we would like to test the hypothesis that the circadian clock is an overt clock involved in aging. Specifically we would like to understand circadian clock control of mitochondria homeostasis. ..
  56. NEONATAL CARBOHYDRATE INTAKE AND HEALTH AT 7-8 YEARS
    Rakesh Sahni; Fiscal Year: 2003
    ..Demonstration that significant changes in these variables are linked to early CHO intake would provide important evidence linking early nutritional practices and vulnerability to adult onset diseases. ..
  57. New Target For Stroke: Peroxisome Proliferator Activated Receptor-Gamma
    Jaroslaw Aronowski; Fiscal Year: 2008
    ..3. To evaluate optimal conditions (selection of drug, dose, time window for effective treatment, tolerance, and effectiveness in permanent vs. reversible ischemia) for the anti-ischemic activity of PPARy agonists. ..
  58. Ethical Issues for Emergency Nurses during Resuscitation of Injured Patients
    MINDY ZEITZER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..