Genomes and Genes
Summary: Abnormally low BODY TEMPERATURE intentionally induced in warm-blooded animals by artificial means.
Publications281 found, 100 shown here
- Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumptionRyan K Bachtell
Department of Behavioural Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, OR 97239, USA
Eur J Neurosci 20:1613-23. 2004..differences in the EW urocortin I system are correlated with ethanol-mediated behaviours such as ethanol-induced hypothermia and ethanol consumption...
- Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trialPeter D Gluckman
The Liggins Institute, University of Auckland, Auckland, New Zealand
Lancet 365:663-70. 2005..We did a multicentre randomised controlled trial to find out if delayed head cooling can improve neurodevelopmental outcome in babies with neonatal encephalopathy...
- Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathySeetha Shankaran
Division of Neonatal Perinatal Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
N Engl J Med 353:1574-84. 2005..Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain...
- Moderate hypothermia to treat perinatal asphyxial encephalopathyDenis V Azzopardi
Division of Clinical Sciences and Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, United Kingdom
N Engl J Med 361:1349-58. 2009..Whether hypothermic therapy improves neurodevelopmental outcomes in newborn infants with asphyxial encephalopathy is uncertain...
- Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular coolingM A De Georgia
Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Neurology 63:312-7. 2004..To report results of a randomized pilot clinical feasibility trial of endovascular cooling in patients with ischemic stroke...
- Intrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathwayMa Qing
German Heart Center Munich, Technical University, Munich, Germany
Crit Care Med 31:2769-75. 2003..CONCLUSION Our results show that hypothermia during cardiopulmonary bypass up-regulates interleukin-10 via STAT-3 activation, which in turn leads to the attenuation of tumor necrosis factor-alpha expression and to hepatic protection...
- Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermiaStephen A Bernard
Intensive Care Unit, Dandenong Hospital, Dandenong, Australia
N Engl J Med 346:557-63. 2002..In a randomized, controlled trial, we compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest...
- Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarctionS Schwab
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 29:2461-6. 1998..Clinical studies on moderate hypothermia in the treatment of acute ischemic stroke patients are still lacking...
- Endovascular cooling for moderate hypothermia in patients with acute stroke: first results of a novel approachD Georgiadis
Department of Neurology, University of Heidelberg, Germany
Stroke 32:2550-3. 2001..CONCLUSIONS: Induction and maintenance of hypothermia with an intravenous cooling device are feasible. The safety of this approach remains to be evaluated...
- A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild Hypothermia Study Group in JapanT Shiozaki
Department of Traumatology, Osaka University Medical School, Kinki University School of Medicine, Japan
J Neurosurg 94:50-4. 2001..A prospective randomized controlled trial was conducted to determine whether mild hypothermia is essential in the treatment of severely head injured patients with low intracranial pressure (ICP)...
- Effects of hypothermia and hyperthermia on cytokine production by cultured human mononuclear phagocytes from adults and newbornsK D Fairchild
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 20201, USA
J Interferon Cytokine Res 20:1049-55. 2000..Hypothermia, on the other hand, may worsen outcome in infections by delaying and prolonging cytokine production...
- Hemicraniectomy and moderate hypothermia in patients with severe ischemic strokeD Georgiadis
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 33:1584-8. 2002....
- Neuroprotective effect of delayed moderate hypothermia after focal cerebral ischemia: an MRI studyR Kollmar
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 33:1899-904. 2002..We examined the influence of delayed hypothermia on secondary ischemic injury, MRI lesion size, and neurological outcome after transient focal cerebral ischemia in a rat model...
- General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damageHeng Zhao
Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
J Cereb Blood Flow Metab 27:1879-94. 2007....
- Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats: the effect of injury severity and brain temperatureElizabeth A Vitarbo
Department of Neurological Surgery, The Neurotrauma Research Center, The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33101, USA
Neurosurgery 55:416-24; discussion 424-5. 2004..This study determined the regional and temporal profile of TNFalpha levels after moderate and severe TBI and assessed the effects of posttraumatic hypothermia or hyperthermia on this proinflammatory cytokine...
- Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxiaM R Battin
Newborn Service, National Women s Hospital, Auckland, New Zealand
Pediatrics 107:480-4. 2001..To determine the neurodevelopmental outcome of infants treated with head cooling with systemic hypothermia after hypoxic-ischemic encephalopathy...
- Induced hypothermia for infants with hypoxic- ischemic encephalopathy using a servo-controlled fan: an exploratory pilot studyAlan Horn
Division of Neonatal Medicine, School of Child and Adolescent Health, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
Pediatrics 123:e1090-8. 2009..The objective of this pilot study was to describe the use, efficacy, and physiologic impact of an inexpensive servo-controlled cooling fan blowing room-temperature air...
- Induced hypothermia for acute strokeThomas M Hemmen
Department of Neuroscience, University of California, San Diego, San Diego, CA 92103 8466, USA
Stroke 38:794-9. 2007b>Induced hypothermia is one of the most promising neuroprotective therapies. Technological limitations and homeostatic mechanisms that maintain core body temperature have impeded the clinical use of hypothermia...
- Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathyAlistair J Gunn
Department of Physiology, University of Auckland, Auckland, New Zealand
J Pediatr 152:55-8, 58.e1. 2008..To evaluate whether therapeutic hypothermia alters the prognostic value of clinical grading of neonatal encephalopathy...
- Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermiaTuomas Oksanen
Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Finland
Resuscitation 80:165-70. 2009....
- Induced hypothermia and fever control for prevention and treatment of neurological injuriesKees H Polderman
Department of Intensive Care, University Medical Center Utrecht, Utrecht, Netherlands
Lancet 371:1955-69. 2008..In particular, the rate of rewarming seems to be an important factor in establishing successful use of hypothermia in the treatment of neurological injuries...
- Mild hypothermia induced by a helmet device: a clinical feasibility studyS Hachimi Idrissi
Department of Critical Care Medicine and Cerebral Resuscitation Research Group, AZ VUB, Free University of Brussels, Laarbeeklaan, 101, B 1090, Brussels, Belgium
Resuscitation 51:275-81. 2001..CONCLUSIONS: Mild hypothermia induced by a helmet device was feasible, easy to perform, inexpensive and effective, with no increase in complications...
- Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysisXue Han Ning
Division of Cardiology, Department of Pediatrics, University of Washington, Seattle 98195, USA
J Appl Physiol (1985) 92:2200-7. 2002..These data imply that hypothermia modifies signaling pathways for apoptosis and suggest possible mechanisms for hypothermia-induced myocardial protection...
- Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric strokeStefan Schwarz
Department of Neurology, University of Heidelberg, Heidelberg, Germany
Stroke 33:497-501. 2002..The purpose of this study was to prospectively evaluate the effects of body position in patients with large supratentorial stroke...
- High-volume hemofiltration after out-of-hospital cardiac arrest: a randomized studyIvan Laurent
Medical ICU, Cochin Teaching Hospital, Rene Descartes University, Paris, France
J Am Coll Cardiol 46:432-7. 2005..The study examined the effect of isovolumic high-volume hemofiltration (HF) alone or combined with mild hypothermia (HT) on survival after out-of-hospital cardiac arrest (OHCA) with initial ventricular fibrillation or asystole...
- The role of hypothermia in the management of severe brain injury: a meta-analysisOdette A Harris
Department of Neurosurgery, Stanford University Medical Center, 300 Pasteur Dr, Edwards Bldg, Second Floor, Stanford, CA 94305, USA
Arch Neurol 59:1077-83. 2002..Hypothermia is utilized in the management of severe traumatic brain injury despite the lack of unequivocal evidence supporting its use. Because of its widespread use, the effects of hypothermia are a concern...
- Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarctionSharon L Hale
The Heart Institute of Good Samaritan Hospital, Los Angeles, CA 90017, USA
Cardiovasc Res 59:715-22. 2003..This study tests the effects of regional hypothermia, initiated late during ischemia and maintained for 2 h of reperfusion, on the no-reflow phenomenon...
- Buspirone and meperidine synergistically reduce the shivering thresholdM Mokhtarani
Department of Anesthesia, University of California, San Francisco, USA
Anesth Analg 93:1233-9. 2001..This combination may facilitate the induction of therapeutic hypothermia in stroke victims...
- Clinical aspects of induced hypothermia in full term neonates with perinatal asphyxiaFloris Groenendaal
Department of Neonatology, Perinatal Center, Wilhelmina Children s Hospital University Medical Center Utrecht, Utrecht, The Netherlands
Early Hum Dev 85:73-6. 2009..Further studies aiming at optimizing onset, duration, and depth of hypothermia in neonates are necessary. Combination of hypothermia with drugs may further improve neuroprotection in asphyxiated full term neonates...
- Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracellular adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemiaKenji Fujimoto
Department of Critical Care and Emergency Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
Pancreas 37:176-81. 2008..To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats...
- The effects of mild induced hypothermia on the myocardium: a systematic reviewFiona E Kelly
Department of Anaesthesia and Intensive Care Medicine, Frenchay Hospital, Bristol, UK
Anaesthesia 65:505-15. 2010Mild induced hypothermia improves neurological outcome and reduces mortality among initially comatose survivors of out-of-hospital cardiac arrest...
- Dexmedetomidine and meperidine additively reduce the shivering threshold in humansAnthony G Doufas
Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
Stroke 34:1218-23. 2003..We tested the hypothesis that meperidine and dexmedetomidine synergistically reduce the shivering threshold without producing substantial sedation or respiratory depression...
- Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic reviewPrakesh S Shah
Department of Paediatrics, Mount Sinai Hospital, and University of Toronto, Ontario, M5G 1X5, Canada
Arch Pediatr Adolesc Med 161:951-8. 2007..0-33.5 degrees C] or mild [>or=33.6 degrees C])...
- Regional expression of constitutive and inducible transcription factors following transient focal ischemia in the neonatal rat: influence of hypothermiaNina G Pabello
Center for Neuropharmacology and Neuroscience, MC 136, Albany Medical College, Albany, NY 12208, USA
Brain Res 1038:11-21. 2005..Thus, focal ischemia in the P7 rat produces different distributions of Fos and pCREB than what has been observed in adult rats subjected to focal ischemia, and expression of these transcription factors can be altered by hypothermia...
- Long-term neurological outcome after cardiac arrest and therapeutic hypothermiaTobias Cronberg
Department of Clinical Sciences, Lund Section for Neurology, Lund University, Sweden
Resuscitation 80:1119-23. 2009..To analyse the neurological status of survivors after cardiac arrest (CA) treated with hypothermia...
- Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 casesJ Jiang
Department of Neurosurgery, Chang Zheng Hospital, Shanghai Neurosurgical Institute, People s Republic of China
J Neurosurg 93:546-9. 2000..The goal of this study was to investigate the protective effects of long-term (3-14 days) mild hypothermia therapy (33-35 degrees C) on outcome in 87 patients with severe traumatic brain injury (TBI) (Glasgow Coma Scale score < or = 8)...
- Studies on fluid extravasation related to induced hypothermia during cardiopulmonary bypass in pigletsJ K Heltne
Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway
Acta Anaesthesiol Scand 45:720-8. 2001..As no leakage of proteins could be demonstrated, based on stable values for albumin and protein masses throughout the experiments, the extravasated fluid contained mainly water and small solutes...
- Regional low-flow perfusion provides cerebral circulatory support during neonatal aortic arch reconstructionF A Pigula
Department of Pediatric Cardiothoracic Surgery, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
J Thorac Cardiovasc Surg 119:331-9. 2000....
- Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unitZ L Lin
Department of Neonatology, Yuying Children s Hospital of Wenzhou Medical College, Wenzhou, China
J Perinatol 26:180-4. 2006..The objective of this study was to determine the efficacy of mild hypothermia via selective head cooling as a neuroprotective therapy in term infants with perinatal asphyxia...
- Cooling methods used in the treatment of exertional heat illnessJ E Smith
Emergency Department, Derriford Hospital, 4 Fort Terrace, Plymouth PL6 5BU, UK
Br J Sports Med 39:503-7; discussion 507. 2005..To review the different methods of reducing body core temperature in patients with exertional heatstroke...
- Rectal temperature reflects tympanic temperature during mild induced hypothermia in nonintubated subjectsRichard M Zweifler
University of South Alabama Stroke Center, Mobile, 36617, USA
J Neurosurg Anesthesiol 16:232-5. 2004Mild induced hypothermia holds promise as an effective neuroprotective strategy following acute stroke and cardiac arrest...
- Hypothermia during reperfusion does not reduce myocardial infarct size in pigsMichael Maeng
Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Brendstrupgaardsvej, 8200 Aarhus N, Denmark
Basic Res Cardiol 101:61-8. 2006..74 +/- 0.09; p = ns vs control for both comparisons). In conclusion, hypothermia during ischemia is strongly myocardioprotective while hypothermia during reperfusion does not reduce myocardial infarct size in human-sized pigs...
- Under-humidification and over-humidification during moderate induced hypothermia with usual devicesFrancois Lellouche
INSERM U 651, Universite Paris XII, Service de Reanimation Medicale, AP HP, Hopital Henri Mondor, 51 Av du Marechal de Lattre de Tassigny, 94010 Creteil, France
Intensive Care Med 32:1014-21. 2006In mechanically ventilated patients with induced hypothermia, the efficacy of heat and moisture exchangers and heated humidifiers to adequately humidify the airway is poorly known...
- Moderate hypothermia in neonatal encephalopathy: efficacy outcomesDorothea J Eicher
Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Pediatr Neurol 32:11-7. 2005..019). Although these results need to be validated in a large clinical trial, this pilot trial provides important data for clinical trial design of hypothermia treatment in neonatal hypoxic-ischemic injury...
- Treatment and outcome in post-resuscitation care after out-of-hospital cardiac arrest when a modern therapeutic approach was introducedM Werling
Division of Cardiology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Resuscitation 73:40-5. 2007..At present, there are no clear guidelines specifying how they should be treated. The aim of this survey was to describe the outcome for initial survivors of out-of-hospital cardiac arrest when a more aggressive approach was applied...
- Mechanisms of hypothermic protection against ischemic liver injury in miceAtsushi Kato
Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Am J Physiol Gastrointest Liver Physiol 282:G608-16. 2002..These data suggest that hypothermia suppresses the hepatic inflammatory response through selective inhibition of JNK and AP-1...
- Cerebral resuscitation: state of the art, experimental approaches and clinical perspectivesErik Popp
Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D 69120, Heidelberg, Germany
Neurol Clin 24:73-87, vi. 2006..Promising animal experimental data concerning the use of thrombolytic agents during cardiopulmonary resuscitation have led to a large European multicenter trial (TROICA trial) that will provide its data in 2006...
- Prolonged moderate hypothermia in massive hemispheric infarction: clinical experienceDidier Milhaud
Neurological Intensive Care Unit, Hopital Gui de Chauliac, CHU Montpellier, France
J Neurosurg Anesthesiol 17:49-53. 2005..Prolonged hypothermia with gamma-hydroxybutyrate can be used to treat MaCI patients, with a fairly good clinical outcome for survivors...
- Mild hypothermia mitigates post-ischemic neuronal death following focal cerebral ischemia in rat brain: immunohistochemical study of Fas, caspase-3 and TUNELP B Phanithi
Department of Pathology, Research Institute for Brain and Blood Vessels, Akita, Japan
Neuropathology 20:273-82. 2000..Further, DNA fragmentation was confirmed by size fractionation in agarose gel. These findings demonstrate a positive relation between the expression of Fas, caspase-3 and TUNEL-positive cells...
- Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic strokeD W Krieger
Cerebrovascular Center, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
Stroke 32:1847-54. 2001..Hypothermia is effective in improving outcome in experimental models of brain infarction. We studied the feasibility and safety of hypothermia in patients with acute ischemic stroke treated with thrombolysis...
- Induced hypothermia in comatose survivors of asphyxia: a case series of 14 consecutive casesS Baldursdottir
Department of Anaesthesia and Intensive Care Medicine, Landspitali University Hospital, Reykjavik, Iceland
Acta Anaesthesiol Scand 54:821-6. 2010b>Induced hypothermia is widely used for comatose survivors of cardiac arrest. Other causes of hypoxic brain injury carry a poor prognosis when treated using traditional methods...
- Endothelin-A receptor antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in ratsSeema Briyal
Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA
Eur J Pharmacol 644:73-9. 2010..The results demonstrate that a combination of acetaminophen and BQ123 is more effective in reducing the neuronal damage following cerebral ischemia, and this combination may be worth investigating in stroke patients...
- Induced hypothermia and determination of neurological outcome after CPR in ICUs in the Netherlands: results of a surveyAline Bouwes
Department of Intensive Care, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
Resuscitation 81:393-7. 2010..The aim of the present survey was to evaluate self-reported implementation of hypothermia after CPR and the methods used to predict neurological outcome at Intensive Care Units (ICUs) in the Netherlands...
- Preliminary clinical outcome study of mild resuscitative hypothermia after out-of-hospital cardiopulmonary arrestY Yanagawa
Department of Traumatology and Critical Care Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
Resuscitation 39:61-6. 1998..Our study, although preliminary, suggests that MH might confer improved outcome, as has been shown in animal models, after CPA. This treatment is associated with an increase in pneumonic complications...
- Effects of induced hypothermia after soft-tissue injuryAndreas Wladis
Department of Surgery, Soder Hospital, Karolinska Institute, 11883 Stockholm, Sweden
Arch Orthop Trauma Surg 124:243-9. 2004..For this purpose, we studied the acute effects of hypothermia induced after infliction of a standardized soft-tissue injury...
- Induced hypothermia attenuates the acute lung injury in hemorrhagic shockKyuseok Kim
Department of Emergency Medicine, Seoul National University College of Medicine, South Korea
J Trauma 68:373-81. 2010..However, the effect of induced HT on acute lung injury (ALI) in HS has not been investigated. We sought to determine the effects of HT on ALI in HS...
- Aminoglycoside pharmacokinetic parameters in neurocritical care patients undergoing induced hypothermiaJessica M Mercer
Department of Pharmacy Services, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Pharmacotherapy 30:654-60. 2010To determine the effects of mild-to-moderate induced hypothermia-a neuroprotectant and/or therapeutic strategy for the management of intracranial hypertension in neurologically injured patients-on the pharmacokinetics of aminoglycoside ..
- Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registryShahid Shafi
Department of Surgery, Division of Burn, Trauma and Surgical Critical Care, University of Texas Southwestern Medical School, Dallas, Texas 75390 9158, USA
J Trauma 59:1081-5. 2005Successful application of induced hypothermia (HT) after stroke and cardiac arrest has led to a resurgence of interest in its potential protective effects in trauma patients...
- The use of induced hypothermia after cardiac arrest: a survey of Canadian emergency physiciansJoel Kennedy
Department of Emergency Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
CJEM 10:125-30. 2008..Despite this, other studies have found that few resuscitation physicians have used hypothermia in clinical practice. The objective of this study was to characterize the use of induced hypothermia by Canadian emergency physicians.
- Induced hypothermia by central venous infusion: saline ice slurry versus chilled salineTerry L Vanden Hoek
University of Chicago, Section of Emergency Medicine, Chicago, IL, USA
Crit Care Med 32:S425-31. 2004..an equal volume of chilled saline. We hypothesized that slurry would achieve core hypothermia (32-34 degrees C) more consistently and at a faster rate...
- Drug-induced hypothermia reduces ischemic damage: effects of the cannabinoid HU-210Ronen R Leker
Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel
Stroke 34:2000-6. 2003..Therefore, we sought to examine whether the synthetic CB1 agonist HU-210 is capable of reducing ischemic damage and to determine the mechanisms responsible for such protection...
- Renal hypothermia achieved by retrograde intracavitary saline perfusionJaime Landman
Division of Urology, Washington University School of Medicine, St Louis, Missouri, USA
J Endourol 16:445-9. 2002..We evaluated the utility of a newly developed ureteral access system for circulating ice-cold saline...
- Keeping a cool head: How to induce and maintain hypothermiaKees H Polderman
Crit Care Med 32:2558-60. 2004
- Induced hypothermia in acute ischemic strokeMarc A Lazzaro
Rush University Medical Center, Department of Neurological Sciences, 1725 W Harrison Street, Suite 1121, Chicago, IL 60612, USA
Expert Opin Investig Drugs 17:1161-74. 2008b>Induced hypothermia is a promising neuroprotective treatment for acute ischemic stroke. Data from both global and focal ischemia animal models have been encouraging...
- Admission hypothermia and outcome after major traumaHenry E Wang
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Crit Care Med 33:1296-301. 2005..The goal of this study was to evaluate the independent association between admission hypothermia and mortality after major trauma, with adjustment for clinical confounders...
- Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2Iori Sakakibara
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan
Cell Metab 9:191-202. 2009..Our findings demonstrate that activation of acetate by AceCS2 plays a pivotal role in thermogenesis, especially under low-glucose or ketogenic conditions, and is crucially required for survival...
- Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal salineFrancis Kim
Department of Medicine, Box 359748, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
Circulation 115:3064-70. 2007..The aims of the present pilot study were to assess the feasibility, safety, and effectiveness of in-field cooling...
- Mechanisms of action, physiological effects, and complications of hypothermiaKees H Polderman
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA
Crit Care Med 37:S186-202. 2009..In recent years important insights have been gained into the mechanisms underlying hypothermia's protective effects; in addition, physiological and pathophysiological changes associated with cooling have become better understood...
- Processed aconite root prevents cold-stress-induced hypothermia and immuno-suppression in miceToshiaki Makino
Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Nagoya City University, Japan
Biol Pharm Bull 32:1741-8. 2009....
- Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global ischemia in ratsW D Dietrich
Department of Neurology, The Miami Project to Cure Paralysis, Miami, Florida, 33101, USA
Exp Neurol 158:444-50. 1999..In postinjury settings where restricted durations of mild hypothermia can be induced, anti-inflammatory treatments, including IL-10, may promote chronic neuroprotection...
- Noninvasive selective brain cooling by head and neck cooling is protective in severe traumatic brain injuryWusi Qiu
BRAIN Center, Department of Neurosurgery, Second Affiliated Hospital, Zhejiang University, School of Medicine, 88 Jiefang Road, Hangzhou 310009, China
J Clin Neurosci 13:995-1000. 2006..In conclusion, the noninvasive SBC described here is a safe method of administering therapeutic hypothermia, which can reduce ICP and improve prognosis without severe complications in patients with severe TBI...
- Hypothermia treatment for traumatic brain injury: a systematic review and meta-analysisKim Peterson
Oregon Evidence Based Practice Center, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurotrauma 25:62-71. 2008..Accordingly, the BTF/AANS guidelines task force has issued a Level III recommendation for optional and cautious use of hypothermia for adults with TBI...
- Induced hypothermia after out-of-hospital cardiac arrest: one hospital's experienceAnn M Whitfield
Intensive Care Unit, Box Hill Hospital, Melbourne, Vic
Crit Care Resusc 11:97-100. 2009..We conducted a retrospective audit to assess whether induced hypothermia had been successfully incorporated into routine care at our hospital, and whether this improved patient ..
- Intra-arrest cooling improves outcomes in a murine cardiac arrest modelBenjamin S Abella
Emergency Resuscitation Center, Section of Emergency Medicine, The University of Chicago, Chicago, Ill 60637, USA
Circulation 109:2786-91. 2004..We sought to determine whether cooling during cardiac arrest before ROSC (ie, "intra-arrest" hypothermia) has survival benefit over more delayed post-ROSC cooling, using a murine cardiac arrest model...
- Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on ResuscitationJ P Nolan
Resuscitation Council of Southern Africa
Circulation 108:118-21. 2003
- Feasibility and safety of moderate hypothermia after massive hemispheric infarctionS Schwab
Department of Neurology, University of Heidelberg, Germany
Stroke 32:2033-5. 2001..This multicenter study was performed to evaluate (1) the safety and feasibility of moderate hypothermia and (2) its potential to reduce intracranial hypertension in acute stroke patients...
- Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermiaMalin Rundgren
Department of Anaesthesia and Intensive Care, Lund University Hospital, Sweden
Resuscitation 80:784-9. 2009..To assess the prognostic value of repetitive serum samples of neuron specific enolase (NSE) and S-100B in cardiac arrest patients treated with hypothermia...
- Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrestRaina M Merchant
Section of Emergency Medicine, University of Chicago, Chicago, IL, USA
Crit Care Med 34:1935-40. 2006..We sought to evaluate current physician use of therapeutic hypothermia after cardiac arrest, to ascertain reasons for nonadoption of this treatment, and to determine current cooling techniques employed...
- Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct sizeC M Maier
Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, California 94305, USA
J Neurosurg 94:90-6. 2001..These studies lend further support to the use of mild hypothermia in the treatment of stroke...
- Epsilon PKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia modelTakayoshi Shimohata
Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Dr R200, Stanford, CA 94305 5327, USA
Stroke 38:375-80. 2007..We studied epsilonPKC activation (by its localization and proteolysis) in a rodent stroke model and correlated the effects of hypothermia with epsilonPKC activity after cerebral ischemia...
- Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injuryJi Yao Jiang
Department of Neurosurgery, Renji Hospital, Shanghai Second Medical University, Shanghai, People s Republic of China
J Cereb Blood Flow Metab 26:771-6. 2006..Our data suggest that 5 days of long-term cooling is more efficacious than 2 days of short-term cooling when mild hypothermia is used to control refractory intracranial hypertension in patients with severe traumatic brain injury...
- Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trialNicola J Robertson
Lancet 372:801-3. 2008
- Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavageGeorge Lotocki
Department of Neurological Surgery, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA
Eur J Neurosci 24:2283-90. 2006..Thus, hypothermia mediates TNFR1 responses via early activation of the JNK signaling pathway and caspase-3, leading to endogenous neuroprotective events...
- Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogsAla Nozari
Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Trauma 57:1266-75. 2004..This study is designed to better mimic the clinical scenario of an exsanguinating trauma victim, for whom suspended animation may buy time for resuscitative surgery and delayed resuscitation...
- Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brainPierre Gressens
INSERM, U676, Paris, France
Brain Pathol 18:10-20. 2008..Longer survival studies are necessary to verify the safety of hypothermia in the developing brain...
- Antegrade selective cerebral perfusion in thoracic aorta surgery: safety of moderate hypothermiaDavide Pacini
Department of Cardiac Surgery, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Eur J Cardiothorac Surg 31:618-22. 2007..The study analyzed the outcomes of aortic surgery using ASCP at different degree of systemic hypothermia...
- Rapid and selective cerebral hypothermia achieved using a cooling helmetHuan Wang
Illinois Neurological Institute, St Francis Medical Center, University of Illinois College of Medicine at Peoria, Illinois 61656, USA
J Neurosurg 100:272-7. 2004..and H.W.) have developed a cooling helmet by using National Aeronautics and Space Administration spinoff technology. In this study its effectiveness in lowering brain temperature in patients with severe stroke or head injury is examined...
- Application of therapeutic hypothermia in the intensive care unit. Opportunities and pitfalls of a promising treatment modality--Part 2: Practical aspects and side effectsKees H Polderman
Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 30:757-69. 2004b>Induced hypothermia can be used to protect the brain from post-ischemic and traumatic neurological injury. Potential clinical applications and the available evidence are discussed in a separate paper...
- Hydrogen sulphide-induced hypothermia attenuates stress-related ulceration in ratsLi Xia Lou
Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing, China
Clin Exp Pharmacol Physiol 35:223-8. 2008..4. In conclusion, a low concentration of H(2)S may be a new pharmacological tool for induced hypothermia to prevent severe stress-induced diseases and multifarious trauma in the clinical setting.
- Arch repair with unilateral antegrade cerebral perfusionSeref A Kucuker
Kardiyovasküler Cerrahi Kliniği, Turkiye Yuksek Ihtisas Hastanesi, Sihhiye, Ankara 06100, Turkey
Eur J Cardiothorac Surg 27:638-43. 2005..This study demonstrates the clinical results of aortic arch repair with unilateral cerebral perfusion via the right brachial artery...
- Long-term effects of hypothermia on neuronal cell death and the concentration of apoptotic proteins after incomplete cerebral ischemia and reperfusion in ratsE Eberspächer
Klinik für Anesthesiologie, Technische Universitat Munchen, Munich, Germany
Acta Anaesthesiol Scand 49:477-87. 2005..The present study investigates the long-term effects of postischemic hypothermia on neuronal cell damage and concentration changes of apoptotic proteins after cerebral ischemia...
- Cold-induced fluid extravasation during cardiopulmonary bypass in piglets can be counteracted by use of iso-oncotic primeMarit Farstad
Department of Anesthesia and Intensive Care, University of Bergen, Haukeland University Hospital, Bergen, Norway
J Thorac Cardiovasc Surg 130:287-94. 2005..This study aimed to compare whether iso-oncotic priming solutions, in contrast to crystalloids, could reduce the cold-induced fluid extravasation during cardiopulmonary bypass in piglets...
- Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysisMichael Holzer
Department of Emergency Medicine, General Hospital Vienna, Medical University of Vienna, Vienna, Austria
Crit Care Med 33:414-8. 2005Only a few patients survive cardiac arrest with favorable neurologic recovery. Our objective was to assess whether induced hypothermia improves neurologic recovery in survivors of primary cardiac arrest.
- The evolution of serum astroglial S-100 beta protein in patients with cardiac arrest treated with mild hypothermiaSaid Hachimi-Idrissi
Cerebral Resuscitation Research Group, Department of Critical Care Medicine, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium
Resuscitation 64:187-92. 2005..To study the effects of mild hypothermia on the 24h concentration of serum astroglial of S-100 beta protein in patients who survived cardiac arrest (CA)...
- Cold infusions alone are effective for induction of therapeutic hypothermia but do not keep patients cool after cardiac arrestAndreas Kliegel
Department of Emergency Medicine, Medical University Vienna, Währinger Gürtel 18 20 6D, 1090 Vienna, Austria
Resuscitation 73:46-53. 2007..This study investigates if hypothermia can be induced and maintained by repetitive infusions of cold fluids and muscle relaxants...
- Hypothermia: a neuroprotective therapy for neonatal hypoxic-ischemic encephalopathyLillian R Blackmon
Division of Neonatology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Pediatrics 117:942-8. 2006
- Development and testing of portable pump for the induction of profound hypothermia in a Swine model of lethal vascular injuriesHasan B Alam
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
J Trauma 61:1321-9. 2006..In this experiment, a portable prototype pump was tested and its performance was compared with the regular roller pump in a swine model of lethal vascular injuries...
- Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB)Midori A Yenari
Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, United States
Neurochem Int 49:164-9. 2006..These data suggest that the protective effect of hypothermia on cerebral injury is, in part, related to NFkappaB inhibition due to decreased activity of IKK...
- Brain cooling causes attenuation of cerebral oxidative stress, systemic inflammation, activated coagulation, and tissue ischemia/injury during heatstrokeShu Fen Hsu
Institute of Physiology, National Yang Ming University School of Medicine, Taipei, Taiwan 112
Shock 26:210-20. 2006....
- Near-drowning treated with therapeutic hypothermiaJonathan P Williamson
Respiratory and Critical Care Medicine, Manly District Hospital, Darcy Road, Manly, Sydney, NSW 2095, Australia
Med J Aust 181:500-1. 2004
- Effects of mild induced hypothermia during experimental sepsisErwan L'Her
Medical Intensive Care Unit, University Hospital, Brest Cedex, France
Crit Care Med 34:2621-3. 2006..We experimentally investigated whether postconditioning temperature modifications influence survival duration during experimental sepsis...
- Hypothermia and Gene Expression After Cardiac ArrestClifton Callaway; Fiscal Year: 2005..BDNF activation as well as the time window during which induction of hypothermia is beneficial suggest that induced hypothermia may affect new gene expression via these signaling systems...
- Regulation of Hepatic Uptake of Endogenous Signaling Molecules and XenobioticsIvan Csanaky; Fiscal Year: 2013..maintaining their body temperature during surgical experiments, but are protected from lipopolysaccharide-induced hypothermia and hyperalgesia...
- Consequences of Cardiac Arrest: Brain InjuryNITISH VYOMESH THAKOR; Fiscal Year: 2013..Aim 2: We will study the mechanism by which induced hypothermia results in enhanced neurophysiologic recovery...
- Stroke Treatment by Chemically-Induced HypothermiaShan Ping Yu; Fiscal Year: 2012..Rather, we aim to demonstrate the feasibility of the chemical-induced hypothermia therapy and move to more systematic preclinical examinations of a Phase II investigation...
- Brain Monitoring and Therapeutic Hypothermia after Cardiac ArrestXiaofeng Jia; Fiscal Year: 2013..Among survivors of cardiac arrest (CA), brain injury is the biggest impediment to functional recovery. Induced hypothermia is currently the only form of therapy that improves both survival and neurological outcome for CA survivors...
- Effects of Hibernation on Hemostasis in 13-lined Ground SquirrelsScott T Cooper; Fiscal Year: 2012..to prevent DVT, store human platelets in the cold, and regulate blood coagulation in cases of accidental or induced hypothermia. PUBLIC HEALTH RELEVANCE: This research may lead to medical advances to prevent blood clots, store human ..
- Mild Hypothermia for Resuscitated Out-of-Hospital Cardiac Arrest PatientsFrancis Kim; Fiscal Year: 2012..Despite this evidence, induced hypothermia is not widely used, and its efficacy in patients with other initial rhythms is largely unstudied...
- Rapid Induction of Therapeutic HypothermiaHarikrishna Tandri; Fiscal Year: 2013..In Phase II, we will develop a clinical-grade device and perform additional pig studies to confirm that the induced hypothermia is safe, effective and is associated with improved outcome of resuscitation and short term neurologic ..
- MOLECULAR BASIS FOR ETHANOL-INDUCED HYPOTHYROIDISMRobert Zoeller; Fiscal Year: 1993..Alcohol-induced hypothermia in rodents has been widely used as a model system to study :he effects of acute and chronic ethanol; ..
- EXERCISE--EFFECTS ON ETOH IMPAIRMENT OF BEHAVIOR IN MICESANDRA MOLLENAUER; Fiscal Year: 1993..4 g/kg EtOH (20% w/v, IP), and also causes significant resistance to EtOH- induced hypothermia and Loss of Righting response (LORR) after 3.8 g/kg EtOH (20% w/v, IP)...
- Anticonvulsants for hypothermic neuroprotection in neonatal ischemic brain injuryFaye Silverstein; Fiscal Year: 2009..PAR-06-189, is to identify clinically feasible interventions that increase the neuroprotective efficacy of induced hypothermia after neonatal hypoxic-ischemic brain injury...
- Adrenergic Receptors During Periadolescent DevelopmentDavid Bylund; Fiscal Year: 2005..abstract_text> ..
- Determinants of Tolerance to Nitrous Oxide HypothermiaKarl Kaiyala; Fiscal Year: 2004..an R21 proposal to investigate the physiological mechanisms of tolerance development to nitrous oxide (N2O)-induced hypothermia. Influential theories of drug tolerance contend that CNS-mediated drug-opposing responses underlie the ..
- ETHANOL AND THE NEUROBIOLOGY OF TEMPERATURE REGULATIONLARRY CRAWSHAW; Fiscal Year: 1990..first part will be utilized in experiments designed to elucidate the central nervous mechanism of ethanol-induced hypothermia. In mice, the site of hypothalamic thermosensitivity will be accurately localized, and the responsiveness ..
- INDIVIDUAL DIFFERENCES AND ADDICTIVE VULNERABILITYDouglas Ramsay; Fiscal Year: 2000..animals that are 1) initially insensitive to N2O induced-hypothermia, 2) initially sensitive to N2O-induced hypothermia but develop acute tolerance during the 4-hour administration, and 3) initially sensitive to N2O-induced ..
- Neuroadaptive Substrates for Nitrous Oxide ToleranceKarl Kaiyala; Fiscal Year: 2006..However, preventing ethanol-induced hypothermia by elevating ambient temperature prevents development of chronic tolerance despite repeated drug ..
- Urocortin, Dorsal Raphe & Ethanol-induced HypothermiaVICTORIA TUREK; Fiscal Year: 2005..identify the role that the urocortinergic projections from the alcohol-responsive EWto the DRN have in EtOH-induced hypothermia. The specific aims of the proposed studies are: 1) To determine what the differences are in the extent of ..
- ONTOGENY OF ETHANOL RESPONSIVITYLinda Spear; Fiscal Year: 1999..ontogeny of acute ethanol sensitivity using a variety of response measures, including assessment of ethanol-induced hypothermia and suppression of startle as well as ethanol-induced alterations in locomotion and in swim speed; dose-..
- Juvenile alcohol exposure: Neurobehavioral consequencesRatna Sircar; Fiscal Year: 2005..Adolescent rats exhibit more tolerance to alcohol-induced hypothermia, and greater impairments in spatial memory than adult rats...
- A MODEL OF FAS: GENERALIZABILITY AND MECHANISMSCarrie Randall; Fiscal Year: 1990..will investigate the effects of aspirin pretreatment on alcohol-induced corticosterone levels, alcohol-induced hypothermia, and alcohol-induced stimulation of prostaglandins (PGE) in morse embryos...
- Cannabinoid Regulation of Basal Ganglia Glutamate and GABASCOTT RAWLS; Fiscal Year: 2007..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
- Can beta-lactam antibiotics decrease morphine physical dependence?SCOTT RAWLS; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- PATHOPHYSIOLOGY OF THROMBOEMBOLIC STROKEW Dietrich; Fiscal Year: 2003..Neuroprotective strategies that may be given to patients with stroke risk factors to prevent the initiation of stroke will be tested. ..
- 23rd - 27th Annual National Neurotrauma SymposiumW Dietrich; Fiscal Year: 2005..In addition, there are two sessions for open communications as well as a panel discussions led by Women in Neurotrauma Research. Specific information regarding the organization of future meetings is also discussed. ..
- Enhancing Recovery after Neonatal StrokeJohn Barks; Fiscal Year: 2008..Together these experiments will provide insights into the mechanisms that mediate and modulate functional recovery after neonatal stroke. [unreadable] [unreadable]..
- IKKBeta Mediated Impairment of Endothelial Nitric Oxide ProductionFrancis Kim; Fiscal Year: 2010..Aim 3. To determine whether the Toll Like Receptor pathway is necessary for endothelial activation of IKKbeta during the development of vascular insulin resistance. ..
- INSULIN RECEPTOR SUBSTRATE -1 AND FLUID SHEAR STRESSFrancis Kim; Fiscal Year: 2005..To further characterize this potential link between insulin and NO signaling. Specific Aim 3: Characterize FSS dependent signaling elements which associate with IRS-1...
- PAF IN PERINATAL CEREBRAL HYPOXIC/ISCHEMIC INJURYJohn Barks; Fiscal Year: 2002..Morphometry and neurobehavioral testing are the primary indices that will be used to evaluate the stability of the neuroprotective efficacy of neonatal post-hypoxic-ischemic PAFF antagonist treatment, as rats reach maturity. ..
- ADENOSINE AND TRAUMATIC BRAIN INJURYPatrick Kochanek; Fiscal Year: 2007..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
- Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical StudiesLance R McMahon; Fiscal Year: 2010..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
- Normobaric Hyperoxia in Acute Ischemic StrokeAneesh B Singhal; Fiscal Year: 2010..Breathing high-flow oxygen may prove to be a simple, practical, portable, and potentially cost-effective therapy that improves stroke outcomes, either independently or by extending the time window for IV tPA. ..
- Cerebral Hemorrhage Model: Mechanisms and TreatmentsKenneth Wagner; Fiscal Year: 2005..abstract_text> ..
- NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATHMichael Dae; Fiscal Year: 2003..These studies may provide a more comprehensive understanding of the interaction of the sympathetic nervous system and arrhythmogenesis. ..
- BRAIN ISCHEMIA AND MAP KINASE ACTIVATIONClifton Callaway; Fiscal Year: 2003..The conduct of this project will provide extensive opportunities for collaboration with other basic scientists at the University of Pittsburgh, and promote the candidate's growth as an independent researcher. ..
- Estrogen and the Aging Blood Brain BarrierOAK CHI; Fiscal Year: 2002..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
- APOE Genotype and Sequelae of Infant Cardiac SurgeryJames Gaynor; Fiscal Year: 2007..unreadable] [unreadable]..
- NEONATAL ENCEPHALOPATHY TREATED BY MODERATE HYPOTHERMIADorothea Jenkins; Fiscal Year: 2001..abstract_text> ..
- Safety of N-acetylcysteine in Maternal ChorioamnionitisDorothea Jenkins; Fiscal Year: 2009....
- Induced hypothermic arrest in traumatic shockHasan Alam; Fiscal Year: 2005..We plan to use clinically relevant large animal models to test the therapeutic application of induced hypothermia following exsanguinating shock...
- Drug discrimination and THC withdrawal in monkeysLANCE MCMAHON; Fiscal Year: 2005..abstract_text> ..
- Nitrous Oxide and Wound InfectionsOzan Akca; Fiscal Year: 2006..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..
- Hypothermia for Pediatric Cardiac Arrest Planning GrantFrank Moler; Fiscal Year: 2004..The CDMCC will make operational all data and analysis related tasks of this application, and assure all study sites are compliant with regulations concerning data security and confidentiality. ..
- SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONSDaniel Sessler; Fiscal Year: 2001..Since the cost of oxygen is trivial and the risks of oxygen administration are low, clinicians will easily be able to implement this treatment once we have demonstrated its benefits. ..
- Planning Hypothermia Trial for Pediatric Cardiac ArrestFrank Moler; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Anesthetics, GABA and the Injured BrainDavid Warner; Fiscal Year: 2006..We believe that GABAAergic pharmacologic properties of volatile anesthetics known to be critical for anesthesia are the same properties that confer cerebral protection. ..
- SPINAL NEURAL ACTIVITY--ROLE IN POST ISCHEMIC INJURYMartin Marsala; Fiscal Year: 2001..The role of HSP72 expression in protection will be tested by examining the effects of antisense pretreatment on HSP72 expression and the same three measures of ischemic damage. ..
- HEADGEAR MONITORING FOR ORTHODONTICSDouglas Ramsay; Fiscal Year: 2002..Feedback on compliance will be readily available to patients, parents, and orthodontists. Improving compliance with headgear wear may have clinically beneficial consequences. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
- Marine Toxin Impacts on Neurobehavioral FunctionEdward Levin; Fiscal Year: 2003..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
- PRESERVATION OF LIVER SLICES BY VITRIFICATIONMichael Taylor; Fiscal Year: 2005..The molecular ice control formulations which provide the highest tissue viability and least interstitial ice formation will be tested in larger animal and human PCLS tissues in a sub-sequent Phase II SBIR proposal. ..
- Pancreas Transporter Development and ValidationMichael Taylor; Fiscal Year: 2006..This research program is supported by collaboration with three major clinical centers interested in validation of this perfusion technology for their future use. [unreadable] [unreadable]..
- EXCITOTOXICITY IN CIRCULATORY ARREST--BRAIN INJURYWilliam Baumgartner; Fiscal Year: 2007....
- Nitrous Oxide, Individual Differences, and ConditioningDouglas Ramsay; Fiscal Year: 2007..individual differences in the physiological mechanisms mediating tolerance to nitrous oxide (N20)-induced hypothermia. Drug tolerance, dependence and withdrawal are thought to be manifestations of a common underlying "..
- Effects of Noise on Newborns < 1000g BirthweightRobert Lasky; Fiscal Year: 2007..The research team consists of respected investigators skilled in assessing NICU noise, evaluating infant responses, and performing randomized trials addressing important short and long term outcomes of ELBW infants. ..
- Role of Endocannabinoid Signaling in AlcoholismBALAPAL BASAVARAJAPPA; Fiscal Year: 2007..The better understanding of these mechanisms will yield new drug therapies with potential in treatment of alcoholism. ..
- Genetic Defects of the Mammalian Circadian clock and PreCheng Lee; Fiscal Year: 2007..In this proposal, we would like to test the hypothesis that the circadian clock is an overt clock involved in aging. Specifically we would like to understand circadian clock control of mitochondria homeostasis. ..
- NEONATAL CARBOHYDRATE INTAKE AND HEALTH AT 7-8 YEARSRakesh Sahni; Fiscal Year: 2003..Demonstration that significant changes in these variables are linked to early CHO intake would provide important evidence linking early nutritional practices and vulnerability to adult onset diseases. ..
- New Target For Stroke: Peroxisome Proliferator Activated Receptor-GammaJaroslaw Aronowski; Fiscal Year: 2008..3. To evaluate optimal conditions (selection of drug, dose, time window for effective treatment, tolerance, and effectiveness in permanent vs. reversible ischemia) for the anti-ischemic activity of PPARy agonists. ..
- Ethical Issues for Emergency Nurses during Resuscitation of Injured PatientsMINDY ZEITZER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..