computer assisted radiotherapy planning

Summary

Summary: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.

Top Publications

  1. ncbi Errors and margins in radiotherapy
    Marcel van Herk
    Department of Radiotherapy, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam
    Semin Radiat Oncol 14:52-64. 2004
  2. ncbi Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy
    David Palma
    Radiation Oncology Program, British Columbia Cancer Agency, Vancouver, BC, Canada
    Int J Radiat Oncol Biol Phys 72:996-1001. 2008
  3. ncbi Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer
    Eric K Hansen
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 64:355-62. 2006
  4. ncbi Four-dimensional computed tomography: image formation and clinical protocol
    Eike Rietzel
    Massachusetts General Hospital, Department of Radiation Oncology, Boston, Massachusetts 02114, USA
    Med Phys 32:874-89. 2005
  5. ncbi The use of active breathing control (ABC) to reduce margin for breathing motion
    J W Wong
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073 6769, USA
    Int J Radiat Oncol Biol Phys 44:911-9. 1999
  6. ncbi Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma
    Eric L Chang
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 68:144-50. 2007
  7. ncbi Comparison of CT- and FDG-PET-defined gross tumor volume in intensity-modulated radiotherapy for head-and-neck cancer
    Arnold C Paulino
    Department of Radiation Oncology, Division of Nuclear Medicine and Molecular Imaging, Emory Clinic and Emory University, Atlanta, GA, USA
    Int J Radiat Oncol Biol Phys 61:1385-92. 2005
  8. ncbi Definition of postlumpectomy tumor bed for radiotherapy boost field planning: CT versus surgical clips
    Hadassah Goldberg
    Department of Oncology, Rambam Medical Center, Haifa, Israel
    Int J Radiat Oncol Biol Phys 63:209-13. 2005
  9. ncbi 4-dimensional computed tomography imaging and treatment planning
    Paul Keall
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond 23298 0058, USA
    Semin Radiat Oncol 14:81-90. 2004
  10. ncbi MRI/linac integration
    Jan J W Lagendijk
    Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan, The Netherlands
    Radiother Oncol 86:25-9. 2008

Detail Information

Publications319 found, 100 shown here

  1. ncbi Errors and margins in radiotherapy
    Marcel van Herk
    Department of Radiotherapy, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam
    Semin Radiat Oncol 14:52-64. 2004
    ..In this article, an overview is given of errors in radiotherapy and margin recipes, based on physical and biological considerations. Respiration motion is treated separately...
  2. ncbi Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy
    David Palma
    Radiation Oncology Program, British Columbia Cancer Agency, Vancouver, BC, Canada
    Int J Radiat Oncol Biol Phys 72:996-1001. 2008
    ..The goal of this study was to compare VMAT prostate RT plans with three-dimensional conformal RT (3D-CRT) and IMRT plans...
  3. ncbi Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer
    Eric K Hansen
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 64:355-62. 2006
    ..We conducted this retrospective study to determine the dosimetric effects of repeat computed tomography (CT) imaging and replanning during the course of intensity-modulated radiotherapy (IMRT) on both normal tissues and target volumes...
  4. ncbi Four-dimensional computed tomography: image formation and clinical protocol
    Eike Rietzel
    Massachusetts General Hospital, Department of Radiation Oncology, Boston, Massachusetts 02114, USA
    Med Phys 32:874-89. 2005
    ..A protocol for 4DCT scanning was evaluated and clinically implemented at the MGH. Patient data are presented to elucidate how additional patient specific parameters can impact 4DCT imaging...
  5. ncbi The use of active breathing control (ABC) to reduce margin for breathing motion
    J W Wong
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073 6769, USA
    Int J Radiat Oncol Biol Phys 44:911-9. 1999
    ..Treatment planning and delivery can then be performed at identical ABC conditions with minimal margin for breathing motion...
  6. ncbi Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma
    Eric L Chang
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 68:144-50. 2007
    ..To evaluate the spatial relationship between peritumoral edema and recurrence pattern in patients with glioblastoma (GBM)...
  7. ncbi Comparison of CT- and FDG-PET-defined gross tumor volume in intensity-modulated radiotherapy for head-and-neck cancer
    Arnold C Paulino
    Department of Radiation Oncology, Division of Nuclear Medicine and Molecular Imaging, Emory Clinic and Emory University, Atlanta, GA, USA
    Int J Radiat Oncol Biol Phys 61:1385-92. 2005
    ....
  8. ncbi Definition of postlumpectomy tumor bed for radiotherapy boost field planning: CT versus surgical clips
    Hadassah Goldberg
    Department of Oncology, Rambam Medical Center, Haifa, Israel
    Int J Radiat Oncol Biol Phys 63:209-13. 2005
    ..To compare the location and extent of the tumor bed as defined by surgical clips and computed tomography (CT) scans, after lumpectomy, for electron boost planning as part of breast radiotherapy...
  9. ncbi 4-dimensional computed tomography imaging and treatment planning
    Paul Keall
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond 23298 0058, USA
    Semin Radiat Oncol 14:81-90. 2004
    ..This article discusses methodology for 4D CT imaging and 4D treatment planning, with some comments on 4D radiation delivery...
  10. ncbi MRI/linac integration
    Jan J W Lagendijk
    Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan, The Netherlands
    Radiother Oncol 86:25-9. 2008
    ..Integrating MRI functionality with an accelerator can make these capacities available for high precision, real time IGRT...
  11. ncbi Comparison of three different mediastinal radiotherapy techniques in female patients: Impact on heart sparing and dose to the breasts
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat Munchen, Munich, Germany
    Radiother Oncol 82:301-7. 2007
    ..Especially in highly curable diseases such as lymphoma, long-term survivors might develop late cardiac damage and radiation-induced second cancer...
  12. ncbi Dose to normal tissues outside the radiation therapy patient's treated volume: a review of different radiation therapy techniques
    James A Purdy
    Department of Radiation Oncology, University of California, Davis Medical Center, Sacramento, CA 95816, USA
    Health Phys 95:666-76. 2008
    ..Dose distributions for the various CRT techniques and the current status of available data for normal tissues, and whole body dose are reviewed...
  13. ncbi Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Int J Radiat Oncol Biol Phys 54:1336-44. 2002
    ..To present our clinical experience using intensity-modulated radiation therapy (IMRT) to improve dose uniformity and treatment efficacy in patients with early-stage breast cancer treated with breast-conserving therapy...
  14. ncbi Intensity-modulated whole pelvic radiation therapy in patients with gynecologic malignancies
    J C Roeske
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    Int J Radiat Oncol Biol Phys 48:1613-21. 2000
    ..To evaluate the ability of intensity-modulated radiation therapy (IMRT) to reduce the volume of small bowel irradiated in women with gynecologic malignancies receiving whole pelvic radiotherapy (WPRT)...
  15. ncbi 18F-FDG PET definition of gross tumor volume for radiotherapy of non-small cell lung cancer: is a single standardized uptake value threshold approach appropriate?
    Kenneth J Biehl
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    J Nucl Med 47:1808-12. 2006
    ....
  16. ncbi Comparison of dose calculation algorithms for treatment planning in external photon beam therapy for clinical situations
    Tommy Knöös
    Radiation Physics, Lund University Hospital, S 221 85 Lund, Sweden
    Phys Med Biol 51:5785-807. 2006
    ..The more sophisticated models in the type b group exhibit changes in both absorbed dose and its distribution which are congruent with the simulations performed by Monte Carlo-based virtual accelerator...
  17. ncbi The dose to the parotid glands with IMRT for oropharyngeal tumors: the effect of reduction of positioning margins
    Bram van Asselen
    Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Radiother Oncol 64:197-204. 2002
    ....
  18. ncbi Dose calculations for external photon beams in radiotherapy
    A Ahnesjö
    Phys Med Biol 44:R99-155. 1999
    ..Finally, a brief overview of inverse methods for optimization and dose reconstruction is provided...
  19. ncbi Comparison of different methods for delineation of 18F-FDG PET-positive tissue for target volume definition in radiotherapy of patients with non-Small cell lung cancer
    Ursula Nestle
    Department for Nuclear Medicine, Saarland University Medical Center, Homburg Saar, Germany
    J Nucl Med 46:1342-8. 2005
    ..This investigation compared the gross tumor volumes (GTVs) resulting from 4 methods used for this purpose in a set of clinical cases...
  20. ncbi On the dosimetric behaviour of photon dose calculation algorithms in the presence of simple geometric heterogeneities: comparison with Monte Carlo calculations
    Antonella Fogliata
    Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland
    Phys Med Biol 52:1363-85. 2007
    ..035 g cm(-3)), enhanced for the most energetic beam. For denser, and more clinical, densities a better agreement among the sophisticated algorithms with respect to MC was observed...
  21. ncbi The management of respiratory motion in radiation oncology report of AAPM Task Group 76
    Paul J Keall
    Virginia Commonwealth University, USA
    Med Phys 33:3874-900. 2006
    ..Respiratory motion management is also appropriate when the procedure will increase normal tissue sparing. Respiratory motion management involves further resources, education and the development of and adherence to QA procedures...
  22. ncbi Osteoradionecrosis of the mandible: minimized risk profile following intensity-modulated radiation therapy (IMRT)
    Gabriela Studer
    Department of Radiation Oncology, University Hospital, Zurich, Switzerland
    Strahlenther Onkol 182:283-8. 2006
    ..The aim of this descriptive study was to assess absolute and relative bone volumes exposed to high IMRT doses, related to observed bone tolerance...
  23. ncbi 4D Proton treatment planning strategy for mobile lung tumors
    Yixiu Kang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 67:906-14. 2007
    ..To investigate strategies for designing compensator-based 3D proton treatment plans for mobile lung tumors using four-dimensional computed tomography (4DCT) images...
  24. ncbi Fractionated stereotactic radiotherapy boost for gynecologic tumors: an alternative to brachytherapy?
    Meritxell Molla
    Servei de Radio Oncologia, Instituto Oncologico Teknon, Barcelona, Spain
    Int J Radiat Oncol Biol Phys 62:118-24. 2005
    ..We aimed to challenge this treatment standard by using stereotactic radiotherapy (SRT) with a linac-based micromultileaf collimator technique...
  25. pmc Elective clinical target volumes for conformal therapy in anorectal cancer: a radiation therapy oncology group consensus panel contouring atlas
    Robert J Myerson
    Department of Radiation Oncology, Washington University, St Louis, MO, USA
    Int J Radiat Oncol Biol Phys 74:824-30. 2009
    ..To develop a Radiation Therapy Oncology Group (RTOG) atlas of the elective clinical target volume (CTV) definitions to be used for planning pelvic intensity-modulated radiotherapy (IMRT) for anal and rectal cancers...
  26. ncbi Radiotherapy treatment plans with RapidArc for prostate cancer involving seminal vesicles and lymph nodes
    Sua Yoo
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 76:935-42. 2010
    ..Dosimetric results and treatment delivery efficiency of RapidArc plans to those of conventional intensity-modulated radiotherapy (IMRT) plans were compared using the Eclipse treatment planning system for high-risk prostate cancer...
  27. ncbi Organ motion and its management
    K M Langen
    National Accelerator Centre, Medical Radiation Group, Faure, South Africa
    Int J Radiat Oncol Biol Phys 50:265-78. 2001
    ..To compile and review data on the topic of organ motion and its management...
  28. ncbi Testing of the analytical anisotropic algorithm for photon dose calculation
    Ann Van Esch
    7Sigma, QA team in Radiotherapy Physics, Belgium and Clinique Ste Elisabeth, Namur, Belgium
    Med Phys 33:4130-48. 2006
    ..Particular progress was made with respect to the penumbra and low dose regions. In heterogeneous materials, improvements are substantial and more pronounced for high (18 MV) than for low (6 MV) energies...
  29. ncbi Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer
    L A Dawson
    Department of Radiation Oncology, University of Michigan, Ann Arbor 48109 0010, USA
    Int J Radiat Oncol Biol Phys 46:1117-26. 2000
    ..To analyze the patterns of local-regional recurrence in patients with head and neck cancer treated with parotid-sparing conformal and segmental intensity-modulated radiotherapy (IMRT)...
  30. ncbi Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation
    Michael K M Kam
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 56:145-57. 2003
    ....
  31. ncbi Dosimetric validation of the anisotropic analytical algorithm for photon dose calculation: fundamental characterization in water
    Antonella Fogliata
    Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland
    Phys Med Biol 51:1421-38. 2006
    ..Additional tests were carried out for enhanced dynamic wedges with results comparable to previous results. The basic dosimetric validation of the AAA was therefore considered satisfactory...
  32. ncbi Reduce in variation and improve efficiency of target volume delineation by a computer-assisted system using a deformable image registration approach
    K S Clifford Chao
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 7030, USA
    Int J Radiat Oncol Biol Phys 68:1512-21. 2007
    ....
  33. ncbi Correction of conebeam CT values using a planning CT for derivation of the "dose of the day"
    Mathilda van Zijtveld
    Department of Radiation Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Radiother Oncol 85:195-200. 2007
    ..However, the use of conebeam CT scans for dose calculation is hampered by inaccuracies in the conversion of CT values to electron densities due to an enlarged scatter contribution...
  34. ncbi Hypofractionated stereotactic radiotherapy for brain metastases--results from three different dose concepts
    Antje Fahrig
    Department of Radiation Therapy and Novalis Shaped Beam Surgery Center of the University of Erlangen, Erlangen, Germany
    Strahlenther Onkol 183:625-30. 2007
    ..To evaluate efficacy and toxicity of hypofractionated stereotactic radiotherapy (hfSRT) with three different dose concepts for irresectable brain metastases not amenable to radiosurgery (SRS) using non-invasive fixation of the skull...
  35. ncbi Simultaneous integrated boost technique by helical tomotherapy for the treatment of glioblastoma multiforme with 11C-methionine PET: report of three cases
    Kazuhiro Miwa
    Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, 630 Shimokobi, Kobi cho, Minokamo, Gifu 505 0034, Japan
    J Neurooncol 87:333-9. 2008
    ..To more clearly define the impact of SIB with HT planning using MET-PET, further investigations are required...
  36. ncbi Time trends in target volumes for stage I non-small-cell lung cancer after stereotactic radiotherapy
    René W M Underberg
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 64:1221-8. 2006
    ..To identify potential time trends in target volumes and tumor mobility after stereotactic radiotherapy (SRT) for Stage I non-small-cell lung cancer...
  37. ncbi Target volume delineation for partial breast radiotherapy planning: clinical characteristics associated with low interobserver concordance
    Ross P Petersen
    Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, Victoria, Canada
    Int J Radiat Oncol Biol Phys 69:41-8. 2007
    ..To examine variability in target volume delineation for partial breast radiotherapy planning and evaluate characteristics associated with low interobserver concordance...
  38. ncbi Dosimetric comparisons of helical tomotherapy and step-and-shoot intensity-modulated radiotherapy in nasopharyngeal carcinoma
    Tsair Fwu Lee
    National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan, ROC
    Radiother Oncol 89:89-96. 2008
    ..The study evaluates and quantifies the potential dosimetric gains of helical tomotherapy (HT) versus step-and-shoot intensity-modulated radiotherapy (SaS-IMRT) for nasopharyngeal carcinoma (NPC)...
  39. ncbi Quantifying the degree of conformity in radiosurgery treatment planning
    Nicoletta J Lomax
    Klinik Im Park, Gamma Knife Centre, Zurich, Switzerland
    Int J Radiat Oncol Biol Phys 55:1409-19. 2003
    ..To compare different parameters used to quantify the quality of a treatment plan and to evaluate the dose conformity and coverage clinically achieved using gamma knife radiosurgery...
  40. ncbi A (short) history of image-guided radiotherapy
    Dirk Verellen
    UZ Brussel, Oncologisch Centrum, Radiotherapie, Belgium
    Radiother Oncol 86:4-13. 2008
    ..Recent developments in improved IT infrastructures, novel irradiation techniques, and better knowledge of functional and morphologic information may have created the need and optimal environment to revive the interest in IGRT...
  41. ncbi Osteoradionecrosis of the mandibula in patients treated with different fractionations
    Gabriela Studer
    Department of Radiation Oncology, University Hospital Zurich, Switzerland
    Strahlenther Onkol 180:233-40. 2004
    ....
  42. ncbi Volumetric and dosimetric evaluation of radiation treatment plans: radiation conformity index
    T Knöös
    Department of Radiation Physics, Lund University Hospital, Sweden
    Int J Radiat Oncol Biol Phys 42:1169-76. 1998
    ..We studied the degree of conformity reached in clinical routines for some common diagnoses treated at our department by calculating a radiation conformity index (RCI)...
  43. ncbi Is intensity-modulated radiotherapy better than conventional radiation treatment and three-dimensional conformal radiotherapy for mediastinal masses in patients with Hodgkin's disease, and is there a role for beam orientation optimization and dose constra
    Theodore Girinsky
    Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    Int J Radiat Oncol Biol Phys 64:218-26. 2006
    ....
  44. ncbi Effects of motion on the total dose distribution
    Thomas Bortfeld
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Semin Radiat Oncol 14:41-51. 2004
    ..An alternative to the use of margins is to do the planning based on blurred dose distributions...
  45. ncbi Intensity-modulated radiation therapy for prostate cancer
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Radiat Oncol 12:229-37. 2002
    ..Clinical trials will be necessary to define more clearly the true extent of improved tumor control and reduction in normal tissue complications with IMRT in the treatment of prostate cancer...
  46. ncbi The impact of IMRT and proton radiotherapy on secondary cancer incidence
    Uwe Schneider
    Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, Triemli Hospital Zurich, 8063 Zurich, Switzerland
    Strahlenther Onkol 182:647-52. 2006
    ..Therefore, X-ray scatter and neutron radiation as well as the impact of the primary dose distribution on secondary cancer incidence are analyzed...
  47. ncbi Comparison of dose calculation algorithms in phantoms with lung equivalent heterogeneities under conditions of lateral electronic disequilibrium
    P Carrasco
    Servei de Radiofísica i Radioprotecció, Hospital de la Santa Creu i Sant Pau, St Antoni Maria Claret 167, 08025 Barcelona, Spain
    Med Phys 31:2899-911. 2004
    ....
  48. ncbi High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions
    Yoshiya Yamada
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 71:484-90. 2008
    ..To report tumor control and toxicity for patients treated with image-guided intensity-modulated radiotherapy (RT) for spinal metastases with high-dose single-fraction RT...
  49. ncbi Comparison of inhomogeneity correction algorithms in small photon fields
    Andrew O Jones
    Department of Radiation Oncology, Geisinger Medical Center, 100 N Academy Avenue, Danville, Pennsylvania 17821, USA
    Med Phys 32:766-76. 2005
    ..For accurate dosimetry of small fields within and near inhomogeneities, however, simple algorithms such as Batho and equivalent pathlength should be avoided...
  50. ncbi The impact of daily setup variations on head-and-neck intensity-modulated radiation therapy
    Theodore S Hong
    Department of Human Oncology, University of Wisconsin Medical School, University Hospital and Clinics, 600 Highland Avenue K4 332, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 61:779-88. 2005
    ..This study provides a detailed analysis regarding the potential impact of daily setup variations on the overall integrity of H&N IMRT...
  51. ncbi Intrathoracic tumour motion estimation from CT imaging using the 3D optical flow method
    Thomas Guerrero
    Division of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Phys Med Biol 49:4147-61. 2004
    ..Surprisingly, oesophageal tumour motion was large and nonuniform, with greatest motion occurring at the gastro-oesophageal junction...
  52. ncbi Conformal therapy for pancreatic cancer: variation of organ position due to gastrointestinal distention--implications for treatment planning
    Eckehard Horst
    Department of Radiation Oncology, University of Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Radiology 222:681-6. 2002
    ..To quantify nonrespiratory organ motion in the pancreatic region and its effect on clinical target volume...
  53. ncbi Treatment planning and verification of proton therapy using spot scanning: initial experiences
    Antony J Lomax
    Paul Scherrer Institute, PSI West Villigen, Aargau 5232 Switzerland
    Med Phys 31:3150-7. 2004
    ..This latter observation may have some consequences when considering strategies for fast re-scanning on second generation scanning gantries...
  54. ncbi Multiple "slow" CT scans for incorporating lung tumor mobility in radiotherapy planning
    F J Lagerwaard
    Department of Radiation Oncology, University Hospital Rotterdam, Rotterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 51:932-7. 2001
    ..6% +/- 10.8% and 54.9% +/- 12.9%. CONCLUSIONS: Larger, and more reproducible, target volumes are generated for peripheral lung tumors with the use of slow CT scans, thereby indicating that slow scans can better capture tumor movement...
  55. ncbi Radiobiological basis and clinical results of the simultaneous integrated boost (SIB) in intensity modulated radiotherapy (IMRT) for head and neck cancer: A review
    Ester Orlandi
    Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy
    Crit Rev Oncol Hematol 73:111-25. 2010
    ....
  56. ncbi Feasibility study of helical tomotherapy for total body or total marrow irradiation
    Susanta K Hui
    Department of Therapeutic Radiology, University of Minnesota, Minneapolis, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Med Phys 32:3214-24. 2005
    ..In addition, conformal radiation to the bone marrow appears feasible in an external radiation treatment using image-guided helical tomotherapy...
  57. ncbi Can PET provide the 3D extent of tumor motion for individualized internal target volumes? A phantom study of the limitations of CT and the promise of PET
    Curtis B Caldwell
    Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 55:1381-93. 2003
    ....
  58. ncbi Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume
    K S Clifford Chao
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 59:43-50. 2004
    ....
  59. ncbi Linear quadratic and tumour control probability modelling in external beam radiotherapy
    S F C O'Rourke
    School of Mathematics and Physics, Queen s University Belfast, Belfast, UK
    J Math Biol 58:799-817. 2009
    ..In particular the recent development of a cell cycle model within the original Zaider and Minerbo TCP formalism is highlighted. Application of this TCP cell-cycle model in clinical treatment plans is explored and analysed...
  60. ncbi Incorporating an improved dose-calculation algorithm in conformal radiotherapy of lung cancer: re-evaluation of dose in normal lung tissue
    Katrien De Jaeger
    Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Radiother Oncol 69:1-10. 2003
    ..We also studied the consequences of these differences on the dose-effect relations for radiation-induced lung injury...
  61. ncbi Organ sparing by conformal avoidance intensity-modulated radiation therapy for anal cancer: dosimetric evaluation of coverage of pelvis and inguinal/femoral nodes
    Yi Jen Chen
    Division of Radiation Oncology, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
    Int J Radiat Oncol Biol Phys 63:274-81. 2005
    ....
  62. ncbi The helical tomotherapy thread effect
    M W Kissick
    Departments of Medical Physics and Engineering Physics, University of Wisconsin Medical School, Madison, Wisconsin 53706 1532, USA
    Med Phys 32:1414-23. 2005
    ..For current typical pitches and beam widths, however, this effect is small and not clinically important for most situations. Certain extremely large field or high pitch cases, however, may benefit from mitigation of this effect...
  63. ncbi Calculation of effective dose from measurements of secondary neutron spectra and scattered photon dose from dynamic MLC IMRT for 6 MV, 15 MV, and 18 MV beam energies
    Rebecca M Howell
    Emory University School of Medicine, Department of Radiation Oncology, 1365 Clifton Road AT200, Atlanta, Georgia 30322, USA
    Med Phys 33:360-8. 2006
    ..This is attributed to the large neutron contribution for 18 MV compared to no neutron contribution for 6 MV...
  64. ncbi A verification study of proposed pelvic lymph node localisation guidelines using nanoparticle-enhanced magnetic resonance imaging
    Maria J Vilarino-Varela
    Department of Clinical Oncology, St Bartholomew s Hospital, London, UK
    Radiother Oncol 89:192-6. 2008
    ..This study aims to verify these guidelines using an independent observer in a further patient cohort...
  65. ncbi Artifacts in computed tomography scanning of moving objects
    George T Y Chen
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Semin Radiat Oncol 14:19-26. 2004
    ..These simulations predict that the effect is clearly observable even if the amplitude is decreased to 0.5 cm. Implications of scanning moving objects on treatment planning are discussed...
  66. pmc Optimization of extracranial stereotactic radiation therapy of small lung lesions using accurate dose calculation algorithms
    Barbara Dobler
    Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany
    Radiat Oncol 1:45. 2006
    ..The aim of this study was to compare and to validate different dose calculation algorithms for the use in radiation therapy of small lung lesions and to optimize the treatment planning using accurate dose calculation algorithms...
  67. ncbi Evaluation of a commercial biologically based IMRT treatment planning system
    Vladimir A Semenenko
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Med Phys 35:5851-60. 2008
    ..Overall, compared to plans based on dose-volume optimization, plans with equivalent target coverage obtained using the biologically based TPS demonstrate improved dose distributions for the majority of normal structures...
  68. ncbi Potential gains for irradiation of chest wall and regional nodes with intensity modulated radiotherapy
    Editha A Krueger
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 56:1023-37. 2003
    ..To develop an intensity modulated radiotherapy (IMRT) technique for postmastectomy RT that improves target coverage while sparing all appropriate normal tissues...
  69. ncbi Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing
    Nesrin Dogan
    Department of Radiation Oncology, Loyola University Chicago Medical Center, Maywood, IL 60153, USA
    Int J Radiat Oncol Biol Phys 57:1480-91. 2003
    ..The purpose of this work was to assess the sequential and simultaneous integrated boost IMRT delivery techniques on target coverage and normal-tissue sparing...
  70. ncbi Low-dose megavoltage cone-beam CT for radiation therapy
    Jean Pouliot
    Department of Radiation Oncology, University of California San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 61:552-60. 2005
    ....
  71. ncbi Ongoing clinical experience utilizing 3D conformal external beam radiotherapy to deliver partial-breast irradiation in patients with early-stage breast cancer treated with breast-conserving therapy
    Frank A Vicini
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, USA
    Int J Radiat Oncol Biol Phys 57:1247-53. 2003
    ..We present our ongoing clinical experience utilizing 3D conformal radiation therapy (3D-CRT) to deliver partial-breast irradiation (PBI) in patients with early-stage breast cancer treated with breast-conserving therapy...
  72. ncbi Four-dimensional proton treatment planning for lung tumors
    Martijn Engelsman
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 64:1589-95. 2006
    ..We compared different treatment planning strategies for lung tumors that compensate for respiratory motion...
  73. ncbi Physical aspects of a real-time tumor-tracking system for gated radiotherapy
    H Shirato
    Department of Radiation Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 48:1187-95. 2000
    ..To reduce uncertainty due to setup error and organ motion during radiotherapy of tumors in or near the lung, by means of real-time tumor tracking and gating of a linear accelerator...
  74. ncbi A conformal index (COIN) to evaluate implant quality and dose specification in brachytherapy
    D Baltas
    Städtische Kliniken Offenbach, Strahlenklinik, Offenbach, Germany
    Int J Radiat Oncol Biol Phys 40:515-24. 1998
    ..To propose a new index (COIN) that can be easily understood and computed to assess high dose rate (HDR) brachytherapy interstitial implant quality and dose specification and is an improvement on existing indexes...
  75. ncbi Time dependence of intrafraction patient motion assessed by repeat stereoscopic imaging
    Mischa S Hoogeman
    Department of Radiation Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 70:609-18. 2008
    ..The data can be used to optimize the intrafraction imaging frequency and consequent patient setup correction with an image guidance and tracking system, and to establish the required safety margins in the absence of such a system...
  76. ncbi Volumetric modulated arc radiotherapy for carcinomas of the oro-pharynx, hypo-pharynx and larynx: a treatment planning comparison with fixed field IMRT
    Eugenio Vanetti
    Oncology Institute of Southern Switzerland, Radiation Oncology Department, Bellinzona, Switzerland
    Radiother Oncol 92:111-7. 2009
    ..A planning study was performed to evaluate the performance of volumetric modulated arc radiotherapy on head and neck cancer patients. Conventional fixed field IMRT was used as a benchmark...
  77. ncbi History of tomotherapy
    T R Mackie
    University of Wisconsin, Madison, WI 53706, USA
    Phys Med Biol 51:R427-53. 2006
    ..The history of helical tomotherapy is also a story of technology migration from academic research to a university-industrial partnership, and finally to commercialization and widespread clinical use...
  78. ncbi Dosimetric verification in participating institutions in a stereotactic body radiotherapy trial for stage I non-small cell lung cancer: Japan clinical oncology group trial (JCOG0403)
    Teiji Nishio
    Radiation Oncology Division, National Cancer Center Hospital East, Kashiwa, Japan
    Phys Med Biol 51:5409-17. 2006
    ..The findings of this study suggest that the clinical results of lung SBRT trials should be carefully evaluated in comparison with the actual dose given to patients...
  79. ncbi Pulmonary complications following different radiotherapy techniques for breast cancer, and the association to irradiated lung volume and dose
    P A Lind
    Department of Radiotherapy, Huddinge University Hospital, Stockholm, Sweden
    Breast Cancer Res Treat 68:199-210. 2001
    ....
  80. ncbi Definition of gross tumor volume in lung cancer: inter-observer variability
    Jan Van de Steene
    Department of Radiotherapy Oncologic Center, Free University of Brussels AZ VUB, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Radiother Oncol 62:37-49. 2002
    ..To determine the inter-observer variation in gross tumor volume (GTV) definition in lung cancer, and its clinical relevance...
  81. ncbi Mid-ventilation CT scan construction from four-dimensional respiration-correlated CT scans for radiotherapy planning of lung cancer patients
    Jochem W H Wolthaus
    Department of Radiation Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 65:1560-71. 2006
    ..The purpose of this study was to develop a simple, new concept to incorporate patient-specific motion information, using 4D-CT scans, in the radiotherapy planning process of lung cancer patients to enable smaller error margins...
  82. pmc Is it beneficial to selectively boost high-risk tumor subvolumes? A comparison of selectively boosting high-risk tumor subvolumes versus homogeneous dose escalation of the entire tumor based on equivalent EUD plans
    Yusung Kim
    Department of Radiation Oncology, University of Iowa, Iowa City, USA
    Acta Oncol 47:906-16. 2008
    ..To quantify and compare expected local tumor control and expected normal tissue toxicities between selective boosting IMRT and homogeneous dose escalation IMRT for the case of prostate cancer...
  83. ncbi Comparing step-and-shoot IMRT with dynamic helical tomotherapy IMRT plans for head-and-neck cancer
    Marco van Vulpen
    Department of Radiation Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 62:1535-9. 2005
    ..The goal of this planning study was to compare step-and-shoot intensity-modulated radiotherapy (IMRT) plans with helical dynamic IMRT plans for oropharynx patients on the basis of dose distribution...
  84. ncbi Four-dimensional radiotherapy planning for DMLC-based respiratory motion tracking
    Paul J Keall
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Med Phys 32:942-51. 2005
    ..However, 4D planning requires new planning tools, such as deformable registration and automated treatment planning on multiple CT image sets...
  85. ncbi A technique for the quantitative evaluation of dose distributions
    D A Low
    Mallinckrodt Institute of Radiology, Division of Radiation Oncology, St Louis, Missouri 63110, USA
    Med Phys 25:656-61. 1998
    ..The determination of gamma throughout the measured dose distribution provides a presentation that quantitatively indicates the calculation accuracy. Examples of a 6 MV beam penumbra are used to illustrate the gamma index...
  86. ncbi Guidance document on delivery, treatment planning, and clinical implementation of IMRT: report of the IMRT Subcommittee of the AAPM Radiation Therapy Committee
    Gary A Ezzell
    Mayo Clinic, Scottsdale, Arizona 85259, USA
    Med Phys 30:2089-115. 2003
    ..This report, while not prescribing specific procedures, provides the framework and guidance to allow clinical radiation oncology physicists to make judicious decisions in implementing a safe and efficient IMRT program in their clinics...
  87. ncbi A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy
    Hiram A Gay
    Department of Radiation Oncology, The Brody School of Medicine at East Carolina University, 600 Moye Boulevard, Greenville, NC 27834, USA
    Phys Med 23:115-25. 2007
    ..Provide a simple research tool that may be used to calculate the NCTP or TCP of a particular treatment plan. Illustrate the implementation of the EUD-based NTCP and TCP models as a research tool...
  88. ncbi Influence of daily setup measurements and corrections on the estimated delivered dose during IMRT treatment of prostate cancer patients
    Paul M A van Haaren
    Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, The Netherlands
    Radiother Oncol 90:291-8. 2009
    ..To evaluate the impact of marker-based position verification, using daily imaging and an off-line correction protocol, by calculating the delivered dose to prostate, rectum and bladder...
  89. ncbi Moving targets: detection and tracking of internal organ motion for treatment planning and patient set-up
    Eike Rietzel
    Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114, USA
    Radiother Oncol 73:S68-72. 2004
    ..We are studying approaches to targeting moving tumors throughout the entire treatment process, from treatment planning to beam delivery...
  90. ncbi Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkin's lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy
    Bhishamjit S Chera
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32206, USA
    Int J Radiat Oncol Biol Phys 75:1173-80. 2009
    ..To compare the dose distribution to targeted and nontargeted tissues in Hodgkin's lymphoma patients using conventional radiotherapy (CRT), intensity-modulated RT (IMRT), and three-dimensional proton RT (3D-PRT)...
  91. ncbi Megavoltage cone-beam CT: system description and clinical applications
    Olivier Morin
    University of California San Francisco Comprehensive Cancer Center, Department of Radiation Oncology, 94143, USA
    Med Dosim 31:51-61. 2006
    ..Current image quality has already proven sufficient for many IGRT applications. Moreover, we expect the range of clinical applications for MV CBCT to grow as imaging technology continues to improve...
  92. ncbi Helical tomotherapy for locoregional irradiation including the internal mammary chain in left-sided breast cancer: dosimetric evaluation
    Jean Michel Caudrelier
    Department of Radiation Oncology, The Ottawa Hospital Cancer Centre, Ont, Canada
    Radiother Oncol 90:99-105. 2009
    ..To compare a standard 3- or 4-field technique to intensity modulated radiotherapy with helical tomotherapy (IMRT-HT) in the planning of locoregional breast radiation including the internal mammary chain (IMC)...
  93. ncbi A new homogeneity index based on statistical analysis of the dose-volume histogram
    Myonggeun Yoon
    Research Institute and Hospital, National Cancer Center, Goyang, Korea
    J Appl Clin Med Phys 8:9-17. 2007
    ..A guideline for evaluating the dose homogeneity of treatment plans based on the S-index and its relation to equivalent uniform dose is discussed...
  94. ncbi Use of deformed intensity distributions for on-line modification of image-guided IMRT to account for interfractional anatomic changes
    Radhe Mohan
    Department of Radiation Physics, Unit 94, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 61:1258-66. 2005
    ..In this paper, we report the development of one such intermediate method that takes into account anatomic changes by deforming the intensity distributions of each beam based on deformations of anatomy as seen in the beam's-eye-view...
  95. ncbi CERR: a computational environment for radiotherapy research
    Joseph O Deasy
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Alvin J Siteman Cancer Center, Washington University Medical Center, St Louis, Missouri 63110, USA
    Med Phys 30:979-85. 2003
    ..In summary, CERR provides a powerful, convenient, and common framework which allows researchers to use common patient data sets, and compare and share research results...
  96. ncbi A treatment planning study comparing HDR and AGIMRT for cervical cancer
    Sasha H Wahab
    Department of Radiation Oncology, Mallinckrodt Institute, Washington University School of Medicine, Box 8224, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Med Phys 31:734-43. 2004
    ..This investigation is being expanded using sequential PET images to model tumor regression and compare brachytherapy and AGIMRT throughout the course of therapy...
  97. ncbi Design of 4D treatment planning target volumes
    Eike Rietzel
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:287-95. 2006
    ..We used four-dimensional computed tomography (4DCT) to characterize tumor motion and create treatment volumes in 10 patients with lung cancer. These were compared with standard treatment volumes...
  98. ncbi Correlation between the treated volume, the GTV and the CTV at the time of brachytherapy and the histopathologic findings in 33 patients with operable cervix carcinoma
    S Muschitz
    Brachytherapy Unit, Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France
    Radiother Oncol 73:187-94. 2004
    ..This study correlates the treated volume, the GTV and the CTV at the time of intracavitary brachytherapy (BT) with the histopathological findings obtained by surgery (S) in 33 patients (pts) with cervix carcinoma...
  99. ncbi Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes
    Antony J Lomax
    Division of Radiation Medicine, Paul Scherrer Institute, Villigen, Switzerland
    Int J Radiat Oncol Biol Phys 55:785-92. 2003
    ....
  100. ncbi Adverse effect of a distended rectum in intensity-modulated radiotherapy (IMRT) treatment planning of prostate cancer
    Matthias Guckenberger
    Department of Radiation Oncology, University of Wuerzburg, Germany
    Radiother Oncol 79:59-64. 2006
    ....
  101. ncbi Selection of beam angles for radiotherapy of skull base tumours using charged particles
    O Jakel
    Deutsches Krebsforschungszentrum Heidelberg, Division for Medical Physics, Germany
    Phys Med Biol 45:1229-41. 2000
    ..Treatment angle combinations are suggested that should be accessible for any beam line design using either fixed beams or a gantry...

Research Grants60

  1. Accurate Models for Predicting Radiation-Induced Injury
    Shiva Das; Fiscal Year: 2009
    ..They will be made publicly available via the Internet. The overall impact of this work will be to facilitate significant reduction in thoracic radiotherapy-induced injury via accurate prediction. ..
  2. Deformable image registration and reconstruction for radiotherapy applications
    Martin J Murphy; Fiscal Year: 2010
    ..The third aim of the project is to develop measurement and validation procedures to assess the accuracy and reliability of these novel image registration and reconstruction techniques. ..
  3. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  4. Web-Based Instruction for Medical Dosimetrists
    Paul Keall; Fiscal Year: 2006
    ..abstract_text> ..
  5. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2002
    ....
  6. Better correlation of outcomes with MC dose calculation
    Indrin Chetty; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. Electromagnetic Tracking of Tumors for Radiotherapy
    Martin Murphy; Fiscal Year: 2006
    ..The augmented Calypso targeting system will be designed for integration into existing radiation therapy systems to provide enhanced beam targeting capability. [unreadable] [unreadable]..
  8. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  9. Digital tomosynthesis: a new paradigm for radiation treatment verification
    Fang Fang Yin; Fiscal Year: 2008
    ..This more frequent and broader range of application will translate into more consistent elimination of tumor and into less damage to nearby healthy tissue. [unreadable] [unreadable] [unreadable]..
  10. Accurate, easy-to-commission radiotherapy beam models
    Bruce Faddegon; Fiscal Year: 2008
    ..This will allow clinics around the country to take advantage of the computational accuracy of this state-of-the-art clinical tool. [unreadable] [unreadable]..
  11. Real-time in Vivo Dosimetry in Radiation Therapy Using Scintillation Detectors
    Sam Beddar; Fiscal Year: 2009
    ..The resulting data can also be used to study dose- related treatment side effects. The ultimate goal of utilizing this method is to improve the delivery of radiotherapy treatments and the quality of life of radiotherapy patients. ..
  12. New Methods for Improved Image-based Dosimetry
    Michael Stabin; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. Temporal Variation of Organ Dose Distribution in RT
    Di Yan; Fiscal Year: 2007
    ..Explore practical methods to include temporal variation of organ dose distribution, estimated from image feedback, in treatment planning optimization. ..
  14. Phase II validation of 4-dimensional computed tomography derived ventilation for
    Thomas Guerrero; Fiscal Year: 2008
    ..Our new imaging method uses equipment already available in almost every radiation oncology clinic. This study seeks to validate our new ventilation imaging with the present standard method. [unreadable] [unreadable] [unreadable]..
  15. Real-Time PDT Dosimetry with Feedback Light Delivery
    Timothy Zhu; Fiscal Year: 2008
    ..abstract_text> ..
  16. Laser acceleration of protons for radiation therapy
    Dale Litzenberg; Fiscal Year: 2007
    ..This research will conduct the first critical step in determining if the cost can be dramatically reduced through the use of new acceleration technology. [unreadable] [unreadable] [unreadable]..
  17. MONTE CARLO SIMULATION OF HIGH ENERGY PHOTON IMAGING
    Yuni Dewaraja; Fiscal Year: 2001
    ..Apart from quantification, this work will have applications in the design of future imaging systems for high energy photons. ..
  18. Virtual Patients for Computing Radiation Doses
    Xie Xu; Fiscal Year: 2007
    ..These two cores then support four parallel clinical projects. [unreadable] [unreadable] [unreadable]..
  19. Radiopharmaceutical Dosimetry Symposium
    Michael Stabin; Fiscal Year: 2002
    ..abstract_text> ..
  20. MONTE CARLO DOSIMETRY FOR INTRAVASCULAR BRACHYTHERAPY
    X Li; Fiscal Year: 2002
    ..abstract_text> ..
  21. HYPOXIC IMAGING GUIDED INTENSITY MODULATED RADIOTHERAPY
    KS CLIFFORD CHAO; Fiscal Year: 2003
    ..They will test the hypothesis by performing multiple Cu-60 ATSM PET scans during the course of irradiation to understand the spatial evolution of hypoxic tumor. ..
  22. Early Prediction of Pathological Response of Chemoradiotherapy with FLT PET
    KS CLIFFORD CHAO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Realistic Phantom Series for OLINDA/EXM Version 2
    Michael Stabin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. 4D Visible Human Modeling for Radiation Dosimetry
    Xie George Xu; Fiscal Year: 2010
    ..4).To establish an internet-based information-sharing resource on virtual-human motion simulation and radiation dosimetry. ..
  25. Method to Guarantee the Quality of Radiotherapy Planning
    Mark Langer; Fiscal Year: 2005
    ..abstract_text> ..
  26. Dose-Volume Modeling of Late Rectal and Bladder Toxicity
    Susan Tucker; Fiscal Year: 2007
    ..We expect the results of our analyses to play an important role in furthering the development of conformal techniques in RT of the prostate and other pelvic sites. ..
  27. Image Guided Integrated Active Breath Hold Radiotherapy
    Geoffrey Hugo; Fiscal Year: 2009
    ..3) Quantify residual setup error in a small population of patients. ..
  28. Image-Guided IMRT for Inter-Fractional Changes
    Radhe Mohan; Fiscal Year: 2008
    ..To accomplish our goal, we intend to leverage the advances we made through our IMRT research in the previous two funding cycles. ..
  29. Computerized Analysis of Mesothelioma on CT Scans
    Samuel Armato; Fiscal Year: 2009
    ....
  30. Preparative irradiation for hepatocyte transplantation
    Chandan Guha; Fiscal Year: 2009
    ..In specific aim 2B, will test whether compensatory regenerative stimuli, provided by methotrexate + HIR-induced liver necrosis, can be used as a substitute to PH. ..
  31. RADIATION DOSE ESCALATION FOR FOCAL LIVER CANCER
    Theodore Lawrence; Fiscal Year: 2005
    ....
  32. SPECT with pinholes separated by slats for high-sensitivity complete imaging
    SCOTT DEAN METZLER; Fiscal Year: 2010
    ..Thus, clinical and research scans that are likely to benefit from this new technique include brain, breast, limb, as well as some pediatric and animal applications. ..
  33. Four-dimensional IMAT planning using graph algorithms
    Cedric X Yu; Fiscal Year: 2010
    ..Successful achievement of the aforementioned project aims will provide planning and practical image guidance for the safe and efficient delivery of IMAT, and significantly improve cancer treatments. ..
  34. Gemcitabine-Radiation for Advanced Pancreatic Cancer
    Theodore S Lawrence; Fiscal Year: 2010
    ..We feel our preclinical and clinical team with a track record of 10 years of carrying out leading clinical trials in this area makes it likely that these studies will improve patient outcome. ..
  35. Image-Guided Interventional Cancer Therapy with Liposomal Radionuclides
    Ande Bao; Fiscal Year: 2010
    ..This method will potentially benefit cancer patients by enhancing tumor drug concentrations and thereby improving tumor therapy while decreasing damage to normal tissue. ..
  36. Spatial-Temporal Imaging of Cell Proliferation & Hypoxia
    Robert Jeraj; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  37. Carbon Nanotube Field Emission Microbeam Array for Single Cell Irradiation
    Sha Chang; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  38. KCD BASED SYSTEM FOR MEGAVOLTAGE PORTAL IMAGING
    Sanjiv Samant; Fiscal Year: 2002
    ..This could facilitate the rapid introduction of conformal therapy into clinical practice by allowing for improved identification of anatomical structures compared to current imaging modalities. ..
  39. COMPUTER AIDED DIAGNOSIS IN CT OF THE THORAX
    Samuel Armato; Fiscal Year: 2004
    ....
  40. Role of ATM in Radiosensitivity of Gliomas
    Chandan Guha; Fiscal Year: 2004
    ..IV) To investigate the combined toxicity of the virus vectors, ATM attenuation and radiation therapy in cultured endothelial cells, astrocytes, oligodendrocytes, neurons and brain tissues in mice models. ..
  41. Transrectal Ultrasound Ablation Of The Prostate
    Gabor Fichtinger; Fiscal Year: 2004
    ..The resulting system will be tested on canine subjects and in a limited manner on human patients. The endpoint of the proposed research is a system for which IRB approval can be sought to conduct clinical trials. ..
  42. Advanced PET/CT Fusion Workstation for Cancer Management
    Lixin Gong; Fiscal Year: 2005
    ..In Phase II we will validate the quality of our system using PET/CT lung data sets of cancer patients. Further algorithmic and PET/CT fusion display enhancements will also be conducted in Phase II. ..
  43. Investigation of Monte Carlo Tools for IMRT
    Chang Ming Ma; Fiscal Year: 2005
    ..The results will be used as reference materials in retrospective studies as well as ongoing clinical trials. ..
  44. Helical Pinhole SPECT for Small-Scale Quantification
    SCOTT METZLER; Fiscal Year: 2006
    ..Another long-term vision for this system is its miniaturization to a table-top research instrument. [unreadable] [unreadable]..
  45. RADIATION THERAPY WITH ACTIVE BREATHING CONTROL
    John Wong; Fiscal Year: 2001
    ..Clinical feasibility of treatment with ABC will also be tested on 25 patients undergoing conventional treatment by studying the reproducibility and acceptance of the procedure by the patients and the treatment personnel. ..
  46. An Image Guided Small Animal Radiation Research Platform
    John Wong; Fiscal Year: 2007
    ..The collaborative efforts are best coordinated in a Bioengineering Research Partnership (BRP). An Oversight Group is formed to evaluate the progress of the BRP, and to help identify opportunities and hypotheses for future research. ..
  47. Liver Radioprotection by Systemic of Regional Amifostine
    Theodore Lawrence; Fiscal Year: 2007
    ..Our preliminary data, research team, and record for translating preclinical findings to the clinic suggest that this proposal is likely to improve the outcome of treatment of patients with diffuse intrahepatic cancer. ..
  48. Improving gene therapy-mediated radiosensitization
    Theodore Lawrence; Fiscal Year: 2006
    ..abstract_text> ..
  49. Experimental Analysis of Advanced Radiotherapy Dosimetry
    JAMES DEMPSEY; Fiscal Year: 2007
    ..Results from this work will provide a paradigm for closing the loop between the clinical treatment planning system and the MLC IMRT delivery system. ..
  50. Standard Database for CT Lung Images
    Samuel Armato; Fiscal Year: 2006
    ..The ideas resented in this proposal are expected to stimulate the efforts of the Consortium toward that goal. ..
  51. Research Center for Emerging Technologies (RCET)
    Jatinder Palta; Fiscal Year: 2006
    ..abstract_text> ..
  52. Accurate and Precise Calibrations for Pinhole SPECT
    SCOTT METZLER; Fiscal Year: 2006
    ..These models are important for accurate quantification. Our goal is to develop the techniques and RS necessary for reconstruction resolutions in the range of approximately 0.5 mm or less. ..
  53. Image-guided radiation therapy of prostate cancer
    Qiuwen Wu; Fiscal Year: 2009
    ..The adoption of image guidance will allow significantly increased local control and reduced radiation induced complications in prostate cancer patients. ..
  54. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2002
    ..that particularly warrant screening using breast CT. The Phase II trial will shed more light on this issue. ..
  55. Hybrid Nuclear/X-ray Projection System for Mouse Imaging
    John Boone; Fiscal Year: 2005
    ..abstract_text> ..
  56. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  57. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  58. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  59. Feasibility of CT in high risk breast cancer patients
    John Boone; Fiscal Year: 2003
    ..The results of this investigation should provide a clear understanding of the potential of breast CT as a tool to reduce breast cancer mortality in the population of women with dire risk of breast cancer. ..