adjuvant radiotherapy

Summary

Summary: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

Top Publications

  1. ncbi Phase III postoperative adjuvant radiotherapy after radical prostatectomy compared with radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate-specific antigen: ARO 96-02/AUO AP 09/95
    Thomas Wiegel
    Department of Radio Oncology, University Hospital Ulm, Ulm, Germany
    J Clin Oncol 27:2924-30. 2009
  2. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
  3. pmc Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial
    Ian M Thompson
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Urol 181:956-62. 2009
  4. ncbi Effects of a yoga program on cortisol rhythm and mood states in early breast cancer patients undergoing adjuvant radiotherapy: a randomized controlled trial
    H S Vadiraja
    Department of Yoga Research, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, India corrected
    Integr Cancer Ther 8:37-46. 2009
  5. ncbi Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial
    Ian M Thompson
    Department of Urology, University of Texas Health Science Center at San Antonio, MC 7845, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    JAMA 296:2329-35. 2006
  6. ncbi Effects of yoga program on quality of life and affect in early breast cancer patients undergoing adjuvant radiotherapy: a randomized controlled trial
    H S Vadiraja
    Department of Yoga Research, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, India
    Complement Ther Med 17:274-80. 2009
  7. ncbi Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial
    Joseph Ragaz
    McGill University Health Center, Royal Victoria Hospital, 687 Pine Ave, Montreal, PQ, Canada H3A 1A1
    J Natl Cancer Inst 97:116-26. 2005
  8. ncbi Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853--a study by the EORTC Breast Cancer Cooperative Group and
    Nina Bijker
    Department of Radiation Oncology, Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 24:3381-7. 2006
  9. ncbi Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial
    M Overgaard
    Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
    Lancet 353:1641-8. 1999
  10. ncbi Effect of margin status on local recurrence after breast conservation and radiation therapy for ductal carcinoma in situ
    Clive Dunne
    Eccles Breast Screening Unit, Mater Misericordiae University Hospital, Dublin, Ireland
    J Clin Oncol 27:1615-20. 2009

Detail Information

Publications340 found, 100 shown here

  1. ncbi Phase III postoperative adjuvant radiotherapy after radical prostatectomy compared with radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate-specific antigen: ARO 96-02/AUO AP 09/95
    Thomas Wiegel
    Department of Radio Oncology, University Hospital Ulm, Ulm, Germany
    J Clin Oncol 27:2924-30. 2009
    ..Two randomized trials demonstrated an advantage for adjuvant radiotherapy (RT) compared with a wait-and-see policy...
  2. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
    ..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
  3. pmc Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial
    Ian M Thompson
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Urol 181:956-62. 2009
    ..Extraprostatic disease will be manifest in a third of men after radical prostatectomy. We present the long-term followup of a randomized clinical trial of radiotherapy to reduce the risk of subsequent metastatic disease and death...
  4. ncbi Effects of a yoga program on cortisol rhythm and mood states in early breast cancer patients undergoing adjuvant radiotherapy: a randomized controlled trial
    H S Vadiraja
    Department of Yoga Research, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, India corrected
    Integr Cancer Ther 8:37-46. 2009
    Objectives. This study compares the effects of an integrated yoga program with brief supportive therapy in breast cancer outpatients undergoing adjuvant radiotherapy at a cancer center.
  5. ncbi Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial
    Ian M Thompson
    Department of Urology, University of Texas Health Science Center at San Antonio, MC 7845, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    JAMA 296:2329-35. 2006
    ..However, the optimal management of these patients after radical prostatectomy is unknown...
  6. ncbi Effects of yoga program on quality of life and affect in early breast cancer patients undergoing adjuvant radiotherapy: a randomized controlled trial
    H S Vadiraja
    Department of Yoga Research, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, India
    Complement Ther Med 17:274-80. 2009
    This study compares the effects of an integrated yoga program with brief supportive therapy in breast cancer outpatients undergoing adjuvant radiotherapy at a cancer centre.
  7. ncbi Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial
    Joseph Ragaz
    McGill University Health Center, Royal Victoria Hospital, 687 Pine Ave, Montreal, PQ, Canada H3A 1A1
    J Natl Cancer Inst 97:116-26. 2005
    ..We report the analysis of data from the 20-year follow-up...
  8. ncbi Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853--a study by the EORTC Breast Cancer Cooperative Group and
    Nina Bijker
    Department of Radiation Oncology, Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 24:3381-7. 2006
    ..We analyzed the efficacy of RT with 10 years follow-up on both the overall risk of local recurrence (LR) and related to clinical, histologic, and treatment factors...
  9. ncbi Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial
    M Overgaard
    Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
    Lancet 353:1641-8. 1999
    ..In a randomised trial among postmenopausal women who had undergone mastectomy, we compared adjuvant tamoxifen alone with tamoxifen plus postoperative radiotherapy...
  10. ncbi Effect of margin status on local recurrence after breast conservation and radiation therapy for ductal carcinoma in situ
    Clive Dunne
    Eccles Breast Screening Unit, Mater Misericordiae University Hospital, Dublin, Ireland
    J Clin Oncol 27:1615-20. 2009
    ..Inadequate margins may result in high local recurrence, and excessively large resections may lead to poor cosmetic outcome without oncologic benefit...
  11. ncbi Early adjuvant radiotherapy toward long-term survival and better quality of life for craniopharyngiomas--a study in single institute
    Sung Ho Moon
    Department of Radiation Oncology, Seoul National University College of Medicine, 28 Yongon Dong, Jongno gu, Seoul, 110 744, South Korea
    Childs Nerv Syst 21:799-807. 2005
    The objective of the study is to compare survival and quality of life (QoL) by the delivery time of adjuvant radiotherapy (RT), early or late, for craniopharyngiomas.
  12. ncbi A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    John P Neoptolemos
    Department of Surgery, Liverpool University, Liverpool, United Kingdom
    N Engl J Med 350:1200-10. 2004
    ..The effect of adjuvant treatment on survival in pancreatic cancer is unclear. We report the final results of the European Study Group for Pancreatic Cancer 1 Trial and update the interim results...
  13. ncbi Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology
    A Recht
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Oncol 19:1539-69. 2001
    ..VALIDATION: Seven outside reviewers, the American Society of Clinical Oncology (ASCO) Health Services Research Committee members, and the ASCO Board of Directors reviewed this document...
  14. ncbi Cancer Care Ontario and American Society of Clinical Oncology adjuvant chemotherapy and adjuvant radiation therapy for stages I-IIIA resectable non small-cell lung cancer guideline
    Katherine M W Pisters
    M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 25:5506-18. 2007
    ..To determine the role of adjuvant chemotherapy and radiation therapy in patients with completely resected stage IA-IIIA non-small-cell lung cancer (NSCLC)...
  15. ncbi An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach
    Sung Kim
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam Gu, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 63:1279-85. 2005
    ..We investigated the effect of postoperative chemoradiotherapy on the relapse rate and survival rate of patients with D2-resected gastric cancer...
  16. ncbi Post mastectomy adjuvant radiotherapy in breast cancer: a comparision of three hypofractionated protocols
    Abubaker Shahid
    Institute of Nuclear Medicine and Oncology INMOL, Wahdat Road, Lahore, Pakistan
    J Pak Med Assoc 59:282-7. 2009
    ..To compare three hypofractionated protocols in postmastectomy cancinoma breast in terms of local control, toxicity and work load...
  17. ncbi Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma
    C L Creutzberg
    Department of Radiation Oncology, University Hospital Rotterdam Daniel den Hoed Cancer Center, The Netherlands
    Lancet 355:1404-11. 2000
    ..We did a multicentre prospective randomised trial to find whether postoperative pelvic radiotherapy improves locoregional control and survival for patients with stage-1 endometrial carcinoma...
  18. pmc Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma
    Matthew H G Katz
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 16:836-47. 2009
    ..We evaluated long-term survival and patterns of recurrence in patients treated for PC with contemporary staging and multimodality therapy...
  19. ncbi Ductal carcinoma in situ, complexities and challenges
    Gregory D Leonard
    Cancer Therapeutics Branch, National Cancer Institute, Bethesda, MD 20889 5105, USA
    J Natl Cancer Inst 96:906-20. 2004
    ..Ongoing and recently completed studies should provide information on outcomes in patients treated with lumpectomy alone and on the effectiveness of aromatase inhibitors as an alternative to tamoxifen...
  20. ncbi Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial
    R A Patchell
    Department of Neurosurgery, University of Kentucky Medical Center, Lexington 40536 0084, USA
    JAMA 280:1485-9. 1998
    ..However, the efficacy of postoperative radiotherapy after complete surgical resection has not been established...
  21. ncbi Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2
    B Chauffert
    Department of Oncology, Anticancer Center G F Leclerc, Dijon, France
    Ann Oncol 19:1592-9. 2008
    ..The role of chemoradiation with systemic chemotherapy compared with chemotherapy alone in locally advanced pancreatic cancer (LAPC) is uncertain...
  22. ncbi Completely resected anaplastic thyroid carcinoma combined with adjuvant chemotherapy and irradiation is associated with prolonged survival
    P I Haigh
    Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Cancer 91:2335-42. 2001
    ..The prognosis of anaplastic thyroid carcinoma (ATC) has been dismal. The objective of this study was to identify prognostic factors in patients who had prolonged survival...
  23. ncbi Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the Danish Breast Cancer Cooperative Group
    Marianne Kyndi
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Arhus Sygehus, Noerrebrogade 44, Building 5, 2, DK 8000 Aarhus C, Denmark
    J Clin Oncol 26:1419-26. 2008
    ....
  24. ncbi Merkel cell carcinoma of the head and neck: is adjuvant radiotherapy necessary?
    Jonathan R Clark
    Department of Head and Neck Surgical Oncology, Princess Margaret Hospital, Toronto, Canada
    Head Neck 29:249-57. 2007
    ..The secondary aims were to determine by stage, which patients derive benefit from combined therapy and to identify predictors for survival on multivariable analysis...
  25. ncbi Quality of life at the end of primary treatment of breast cancer: first results from the moving beyond cancer randomized trial
    Patricia A Ganz
    School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    J Natl Cancer Inst 96:376-87. 2004
    ..We investigated the baseline psychosocial status of women enrolled in a randomized trial testing two psychosocial interventions for women at the end of primary treatment...
  26. pmc The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial
    S M Bentzen
    Lancet Oncol 9:331-41. 2008
    ..We tested two dose levels of a 13-fraction schedule against the standard regimen with the aim of measuring the sensitivity of normal and malignant tissues to fraction size...
  27. ncbi Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 26:2373-8. 2008
    ..To determine whether breast cancer subtype is associated with outcome after breast-conserving therapy (BCT) consisting of lumpectomy and radiation therapy...
  28. ncbi Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis
    Val Gebski
    National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia
    Lancet Oncol 8:226-34. 2007
    ..We aimed to clarify the benefits of neoadjuvant chemoradiotherapy or chemotherapy versus surgery alone by a meta-analysis of randomised trial data...
  29. ncbi Surgery and adjuvant radiotherapy in patients with cutaneous head and neck squamous cell carcinoma metastatic to lymph nodes: combined treatment should be considered best practice
    Michael J Veness
    Head and Neck Cancer Service, Westmead Hospital, University of Sydney, Sydney, Australia michael radonc wsahs nsw gov au
    Laryngoscope 115:870-5. 2005
    ..Recent data support best outcome with the addition of adjuvant radiotherapy. This study aims to present further supportive evidence.
  30. ncbi Surgical monotherapy versus surgery plus adjuvant radiotherapy in high-risk cutaneous squamous cell carcinoma: a systematic review of outcomes
    Anokhi Jambusaria-Pahlajani
    Division of Dermatologic Surgery, Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Dermatol Surg 35:574-85. 2009
    b>Adjuvant radiotherapy (ART) has been recommended for squamous cell carcinoma(SCC) with a high risk of recurrence, particularly perineurally invasive disease. The utility of ART is unknown...
  31. ncbi Radiation injury to intestine following hysterectomy and adjuvant radiotherapy for cervical cancer
    Shang Wen Chen
    Department of Radiation Therapy and Oncology, China Medical University Hospital, Taichung 404, Taiwan
    Gynecol Oncol 95:208-14. 2004
    To evaluate the risk factors for nonrectal radiation-induced intestinal injury (NRRIII) following adjuvant radiotherapy (RT) for cervical cancer using a retrospective review of medical records.
  32. ncbi Once more confirmed: adjuvant radiotherapy and improved local control provide a significant survival benefit for early breast cancer patients
    Marie Luise Sautter-Bihl
    Strahlenther Onkol 182:199-201. 2006
  33. ncbi Merkel cell carcinoma: improved outcome with adjuvant radiotherapy
    Michael J Veness
    Head and Neck Cancer Service, Westmead Hospital, Sydney, Australia
    ANZ J Surg 75:275-81. 2005
    ..Patients remain at high risk of locoregional and distant relapse despite treatment. Most studies support the incorporation of locoregional adjuvant radiotherapy in reducing the risk of relapse.
  34. ncbi Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter
    A Muacevic
    Department of Neurosurgery, Ludwig Maximilians University, Klinikum Grosshadern, and Gamma Knife Center, Munich, Germany
    J Neurosurg 91:35-43. 1999
    ....
  35. ncbi Adjuvant radiotherapy of women with breast cancer - information, support and side-effects
    K Sjovall
    Department of Oncology, Lund University Hospital, S 221 85 Lund, Sweden
    Eur J Oncol Nurs 14:147-53. 2010
    ..was to 1) examine the occurrence and burden of side effects over time in the period after post surgical adjuvant radiotherapy in women with breast cancer and 2) explore the women's experiences of given information and need of ..
  36. ncbi Angiogenic markers show high prognostic impact on survival in marginally operable non-small cell lung cancer patients treated with adjuvant radiotherapy
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    J Thorac Oncol 4:463-71. 2009
    ..Both expression and its prognostic impact may be associated with patient selection. Data addressing the prognostic relevance of angiogenic marker expression in NSCLC patients treated with postoperative radiotherapy (PORT) is warranted...
  37. ncbi Cutaneous head and neck squamous cell carcinoma metastatic to cervical lymph nodes (nonparotid): a better outcome with surgery and adjuvant radiotherapy
    Michael J Veness
    Head and Neck Unit, Department of Radiation Oncology, Westmead Hospital, Westmead, NSW 2145, Sydney, Australia
    Laryngoscope 113:1827-33. 2003
    ..The aim of this study is to report on the experience of treating cutaneous squamous cell carcinoma (SCC) metastatic to cervical (nonparotid) lymph nodes at the Head and Neck Unit, Westmead Hospital, Sydney, Australia...
  38. ncbi Descriptive nomograms of adjuvant radiotherapy use and patterns of care analysis for stage I and II endometrial adenocarcinoma: A surveillance, epidemiology, and end results population study
    Christopher M Lee
    Department of Radiation Oncology, Huntsman Cancer Hospital and University of Utah Medical Center, Salt Lake City, Utah 99202, USA
    Cancer 110:2092-100. 2007
    ..cancer remains the most common gynecologic malignancy in the United States, differing approaches to adjuvant radiotherapy treatment for early disease exist within the medical community because of the lack of a national consensus.
  39. ncbi Accelerated partial breast irradiation as a part of breast conservation therapy
    Douglas W Arthur
    Radiation Oncology Department, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA, USA
    J Clin Oncol 23:1726-35. 2005
  40. ncbi Long-term events in adult patients with clinical stage IA-IIA nonbulky Hodgkin's lymphoma treated with four cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine and adjuvant radiotherapy: a single-institution 15-year follow-up
    Ercole Brusamolino
    Clinica Ematologica and Servizio di Radioterapia Oncologica, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, University of Pavia, Pavia, Italy
    Clin Cancer Res 12:6487-93. 2006
    To report on long-term events after short doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy and adjuvant radiotherapy in favorable early-stage Hodgkin's lymphoma.
  41. pmc Impact of pathological characteristics on local relapse after breast-conserving therapy: a subgroup analysis of the EORTC boost versus no boost trial
    Heather A Jones
    Department of Radiation Oncology, University of Pittsburgh Cancer Center, Pittsburgh, PA, USA
    J Clin Oncol 27:4939-47. 2009
    ..To investigate the long-term impact of pathologic characteristics and an extra boost dose of 16 Gy on local relapse, for stage I and II invasive breast cancer patients treated with breast conserving therapy (BCT)...
  42. ncbi Long-term follow-up of patients with prostate cancer and nodal metastases treated by pelvic lymphadenectomy and radical prostatectomy: the positive impact of adjuvant radiotherapy
    Luigi F Da Pozzo
    Department of Urology, Vita Salute University, Milan, Italy
    Eur Urol 55:1003-11. 2009
    Recent large, prospective, randomised studies have demonstrated that adjuvant radiotherapy (RT) is a safe and effective procedure for preventing disease recurrence in locally advanced prostate cancer (PCa) patients...
  43. ncbi Surgically staged high-risk endometrial cancer: randomized study of adjuvant radiotherapy alone vs. sequential chemo-radiotherapy
    Tapio Kuoppala
    Tampere University Hospital, Finland
    Gynecol Oncol 110:190-5. 2008
    ..Our purpose was to establish whether platinum-based chemotherapy combined with standard surgery and radiotherapy will improve overall and disease-free survival and lower the recurrence rate in patients with high-risk endometrial cancer...
  44. ncbi Thymoma: state of the art
    C R Thomas
    Department of Radiation Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Oncol 17:2280-9. 1999
    ..b>Adjuvant radiotherapy seems to improve local control and survival...
  45. ncbi Selecting breast cancer patients with T1-T2 tumors and one to three positive axillary nodes at high postmastectomy locoregional recurrence risk for adjuvant radiotherapy
    Pauline T Truong
    Radiation Therapy Program, British Columbia Cancer Agency Vancouver Island Centre and University of British Columbia, Victoria, BC, Canada
    Int J Radiat Oncol Biol Phys 61:1337-47. 2005
    ....
  46. ncbi Management of merkel cell carcinoma: the roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapy
    Ross E Warner
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
    Ann Surg Oncol 15:2509-18. 2008
    ..However, its optimal treatment is uncertain. In this study, we aimed to assess the roles of lymphoscintigraphy and sentinel node (SN) biopsy, as well as radiotherapy, in the treatment of MCC...
  47. ncbi Prognostic significance of vascular endothelial growth factor and cyclooxygenase-2 in patients with rectal cancer treated with preoperative radiotherapy
    Jordi Giralt
    Department of Radiation Oncology, Hospital Vall d Hebron, Barcelona, Spain
    Oncology 71:312-9. 2006
    ..To analyze the prognostic value of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in patients with locally advanced rectal cancer treated with preoperative radiotherapy...
  48. ncbi Adjuvant therapy in rectal cancer: analysis of stage, sex, and local control--final report of intergroup 0114
    J E Tepper
    Department of Radiation Oncology, University of North Carolina, Chapel Hill 27599 7512, USA
    J Clin Oncol 20:1744-50. 2002
    ....
  49. ncbi Adjuvant radiotherapy in non-small cell lung cancer with pathological stage I: definitive results of a phase III randomized trial
    Lucio Trodella
    Department of Radiation Oncology, Universita Cattolica del S Cuore, Largo A Gemelli 8, 00168, Rome, Italy
    Radiother Oncol 62:11-9. 2002
    ..To evaluate the benefits and the drawbacks of post-operative radiotherapy in completely resected Stage I (a and b) non-small cell lung cancer (NSCLC)...
  50. ncbi Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation
    Yoann Pointreau
    Centre Hospitalier Regional et Universitaire, Henry Kaplan Center, Clinique d Oncologie et de Radiothérapie, Tours, France
    J Natl Cancer Inst 101:498-506. 2009
    ..Data suggest that docetaxel (T) may add to the efficacy of PF. The objective of this trial was to determine whether adding T to PF could increase the larynx preservation rate...
  51. ncbi A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer
    John D Urschel
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Am J Surg 185:538-43. 2003
    ..We performed a meta-analysis of randomized controlled trials (RCTs) that compared the use of neoadjuvant chemoradiation and surgery with the use of surgery alone for esophageal cancer...
  52. ncbi Adjuvant radiotherapy after mastectomy for pT1-pT2 node negative (pN0) breast cancer: is it worth the effort?
    Mia Voordeckers
    Department of Radiotherapy, Academic Hospital V U B, Laarbeeklaan 101, 1090 Jette, Brussels, Belgium
    Radiother Oncol 68:227-31. 2003
    ..Since little data on the importance of RT in this subgroup are known, we reviewed the clinical records with regard to overall survival...
  53. ncbi Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer
    Claus Rodel
    Department of Radiation Therapy, University of Erlangen, Universitatsstr 27, D 91054 Erlangen, Germany
    J Clin Oncol 23:8688-96. 2005
    ..We assessed the impact of tumor regression grading (TRG) and its value in correlation to established prognostic factors in a cohort of rectal carcinoma patients treated by preoperative chemoradiotherapy (CRT)...
  54. ncbi Breast cancer: improving outcome following adjuvant radiotherapy
    J A Violet
    The Royal Marsden NHS Trust, Fulham Road, London SW3 6JJ, UK
    Br J Radiol 77:811-20. 2004
    ..In this review we outline the indications and benefits of breast radiotherapy along with the planning process. Technical advances are discussed within the context of improving outcome at a time of limited national resources...
  55. ncbi Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma
    Martin Fassnacht
    University of Wuerzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit, Wuerzburg, Germany
    J Clin Endocrinol Metab 91:4501-4. 2006
    ..Although radiotherapy is often considered ineffective in the treatment of ACC, the limited number of available studies does not support this statement...
  56. ncbi A systematic overview of radiation therapy effects in soft tissue sarcomas
    Hans Strander
    Department of Oncology, Karolinska Hospital, Stockholm, Sweden
    Acta Oncol 42:516-31. 2003
    ..There is strong evidence that adjuvant radiotherapy improves the local control rate in combination with conservative surgery in the treatment of STS of ..
  57. ncbi Skin-sparing mastectomy
    Giles H Cunnick
    Department of Breast Surgery, St George s Hospital, Tooting, London, United Kingdom
    Am J Surg 188:78-84. 2004
    ..It facilitates immediate breast reconstruction using an implant or myocutaneous flap, resulting in excellent cosmesis...
  58. ncbi Gamma knife radiosurgery for brain metastases: do patients benefit from adjuvant external-beam radiotherapy? An 18-month comparative analysis
    Ajay Jawahar
    Department of Neurosurgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130 3932, USA
    Stereotact Funct Neurosurg 79:262-71. 2002
    ..To analyze 18 months of results of gamma knife stereotactic radiosurgery in the treatment of brain metastases and determine factors affecting outcome by examining the effectiveness of additional external-beam radiotherapy (XRT)...
  59. ncbi A prospective population-based management program including primary surgery and postoperative risk assessment by means of DNA ploidy and histopathology. Adjuvant radiotherapy is not necessary for the majority of patients with FIGO stage I-II endometrial c
    T Hogberg
    Department of Gynecologic Oncology, University Hospital, Linkoping, Sweden
    Int J Gynecol Cancer 14:437-50. 2004
    ..Thus, effective systemic treatments need to be developed. Low-risk patients, constituting the majority (84%) of the patients, can be safely treated by surgery only...
  60. ncbi Concurrent adjuvant radiotherapy and interferon-alpha2b for resected high risk stage III melanoma -- a retrospective single centre study
    David E Gyorki
    Peter MacCallum Cancer Centre, Skin and Melanoma Service, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    Melanoma Res 14:223-30. 2004
    ..and radiation-related toxicities in patients treated with combined adjuvant IFNalpha2b and regional adjuvant radiotherapy delivered in the setting of a single institution...
  61. ncbi Delay in initiating adjuvant radiotherapy following breast conservation surgery and its impact on survival
    Dawn L Hershman
    Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 65:1353-60. 2006
    ..We investigated factors that influence the time interval between lumpectomy and RT, and the association between that interval and survival...
  62. ncbi Findings on 18F-FDG PET scans after neoadjuvant chemoradiation provides prognostic stratification in patients with locally advanced rectal carcinoma subsequently treated by radical surgery
    Victor Kalff
    Center for Molecular Imaging, The Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    J Nucl Med 47:14-22. 2006
    ..We evaluated the prognostic information obtained from the degree of change in tumor (18)F-FDG PET uptake induced by chemoradiation before radical curative surgery in patients with T3/T4 rectal cancer...
  63. ncbi Meeting highlights: international expert consensus on the primary therapy of early breast cancer 2005
    A Goldhirsch
    International Breast Cancer Study Group, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Ann Oncol 16:1569-83. 2005
    ....
  64. ncbi Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer
    K Bujko
    Department of Radiotherapy, Maria Sklodowska Curie Memorial Cancer Centre, Warsaw, Poland
    Br J Surg 93:1215-23. 2006
    ..The aim of this study was to compare survival, local control and late toxicity in the two treatment groups...
  65. ncbi 18F-FDG PET for assessment of therapy response and preoperative re-evaluation after neoadjuvant radio-chemotherapy in stage III non-small cell lung cancer
    Susanne Martina Eschmann
    Department of Nuclear Medicine, University of Tubingen, Otfried Mueller Strasse 14, 72076, Tubingen, Germany
    Eur J Nucl Med Mol Imaging 34:463-71. 2007
    ..The aim of this study was to evaluate FDG-PET for assessment of therapy response and for prediction of patient outcome after neo-adjuvant radio-chemotherapy (NARCT) of advanced non-small cell lung cancer (NSCLC)...
  66. ncbi Surgical treatment variation in a prospective, randomized trial of chemoradiotherapy in gastric cancer: the effect of undertreatment
    Scott A Hundahl
    Queen s Cancer Institute, Honolulu, Hawaii 96813, USA
    Ann Surg Oncol 9:278-86. 2002
    ..Intergroup 0116 (Southwest Oncology Group 9008), a national, multicenter, two-armed, prospective, randomized trial of adjuvant postoperative chemoradiotherapy, has demonstrated significant benefit...
  67. ncbi Adjuvant radiotherapy for stage I endometrial cancer: systematic review and meta-analysis
    A Kong
    Radiotherapy Department, St Bartholomew s Hospital, London EC1
    Ann Oncol 18:1595-604. 2007
    The role of adjuvant radiotherapy in stage I endometrial cancer following surgery remains unclear. The management for these patients varies widely, particularly in stage I patients with different risk factors...
  68. ncbi Limitations of adjuvant radiotherapy for uterine sarcomas spread beyond the uterus
    Kathryn E Dusenbery
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    Gynecol Oncol 94:191-6. 2004
    ..The present review analyzes patients with advanced uterine sarcomas with the goal of identifying patients likely to benefit from larger volumes and higher dosages of radiotherapy...
  69. ncbi Adjuvant treatment of colorectal cancer
    Brian M Wolpin
    Dana Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Boston, MA, USA
    CA Cancer J Clin 57:168-85. 2007
    ..Current randomized clinical trials in the adjuvant therapy of colorectal cancer are examining the value of adding agents known to be active in metastatic disease, including those that modify specific molecular targets...
  70. ncbi Late results of skin-sparing mastectomy followed by immediate breast reconstruction
    T J Meretoja
    Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Br J Surg 94:1220-5. 2007
    ..Concerns persist that SSM might increase the rate of local recurrence as the surgical approach is less extensive. Patients who had SSM and IBR over 10 years at a single institution were reviewed...
  71. ncbi Adjuvant radiotherapy and survival for patients with node-positive head and neck cancer: an analysis by primary site and nodal stage
    Johnny Kao
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 71:362-70. 2008
    b>Adjuvant radiotherapy (RT) is frequently recommended for node-positive head and neck squamous cell carcinoma (HNSCC) treated with primary surgery...
  72. ncbi What is the role of adjuvant radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion?
    Anne Han
    College of Physicians and Surgeons, Columbia University Medical Center, New York, New York 10032, USA
    Cancer 109:1053-9. 2007
    ..To date, the effectiveness of adjuvant XRT in this setting has not been determined definitively...
  73. ncbi Postoperative irradiation in breast cancer patients with one to three positive axillary lymph nodes. Is there an impact of axillary extranodal tumor extension on locoregional and distant control?
    Heidi Stranzl
    Department of Radiotherapy Radiooncology, University Medical School, Graz, Austria
    Strahlenther Onkol 182:583-8. 2006
    ..As shown in literature, ECE is diagnosed in up to 30% of node-positive breast cancer patients. Consequences of ECE and prognosis of these patients are unclear...
  74. ncbi Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women
    Giovanni Battista Ivaldi
    Department of Radiation Oncology, European Institute of Oncology, Milan, Italy
    Int J Radiat Oncol Biol Phys 72:485-93. 2008
    ..To report the acute and preliminary data on late toxicity of a pilot study of boost with electron intraoperative therapy followed by hypofractionated external beam radiotherapy (HEBRT) of the whole breast...
  75. ncbi Gastric cancer: epidemiology, pathology and treatment
    S R Alberts
    Mayo Clinic, Rochester, MN, USA
    Ann Oncol 14:ii31-6. 2003
    ..Adjuvant chemotherapy or adjuvant radiotherapy, when used alone, do not improve survival following resection...
  76. ncbi Prognostic significance of several histological features in intermediate and high-risk endometrial cancer patients treated with curative intent using surgery and adjuvant radiotherapy
    K Narayan
    Department of Radiation Oncology, Peter MacCallum Cancer Centre, A Beckett Street, Melbourne, Victoria 8006, Australia
    J Med Imaging Radiat Oncol 53:107-13. 2009
    ..Absolute MI and tumour grading were useful predictors of nodal spread...
  77. ncbi Adjuvant radiotherapy use and patterns of care analysis for margin-positive prostate adenocarcinoma with extracapsular extension: postprostatectomy adjuvant radiotherapy: a SEER analysis
    Amol J Ghia
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
    Urology 76:1169-74. 2010
    ..To perform a patterns of care analysis for patients with prostate cancer and high-risk pathologic factors following radical prostatectomy with regards to adjuvant radiation...
  78. ncbi Short course continuous, hyperfractionated, accelerated radiation therapy (CHART) as preoperative treatment for rectal cancer
    S Brooks
    Mount Vernon Cancer Center, Northwood, Middlesex, HA6 2RN, London, United Kingdom
    Acta Oncol 45:1079-85. 2006
    ..This small study suggests preoperative short course CHART for clinically resectable rectal carcinoma is feasible with acceptable compliance and tolerable side effects...
  79. ncbi A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study
    Henry M Keys
    Department of Radiation Oncology, Albany Medical College, Albany, NY 12208, USA
    Gynecol Oncol 92:744-51. 2004
    ....
  80. ncbi Treatment of cervical cancer with adjuvant chemotherapy versus adjuvant radiotherapy after radical hysterectomy and systematic lymphadenectomy
    Masayoshi Hosaka
    Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Obstet Gynaecol Res 34:552-6. 2008
    ..To compare the clinical efficacy focused on post-treatment morbidity between adjuvant chemotherapy (CT) and pelvic radiotherapy (RT) after radical hysterectomy for patients with cervical cancer...
  81. ncbi Comparison of surgery alone with surgery and adjuvant radiotherapy for pT3N0 prostate cancer
    Z Petrovich
    Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    BJU Int 89:604-11. 2002
    ..To compare the outcome between patients with pT3N0 adenocarcinoma of the prostate treated with radical prostatectomy (RP) and those receiving RP followed by a planned course of postoperative radiation therapy (RT)...
  82. ncbi No serious late cardiac effects after adjuvant radiotherapy following mastectomy in premenopausal women with early breast cancer
    A Gustavsson
    Department of Oncology, University Hospital, Lund, Sweden
    Int J Radiat Oncol Biol Phys 43:745-54. 1999
    To assess cardiac mortality, coronary artery disease, myocardial dysfunction, and valvular heart disease in women younger than 65 years of age, at least 10 years after adjuvant radiotherapy following mastectomy in early breast cancer.
  83. ncbi Effect of adjuvant radiotherapy on local recurrence in stage II rectal cancer
    In Ja Park
    Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, and Asan Cancer Center, Seoul 138 736, Korea
    Ann Surg Oncol 15:519-25. 2008
    ..Some patients with stage II lesions, however, have relatively low risks of local recurrence. We evaluated the effect of radiotherapy on local recurrence in patients with stage IIA rectal cancer...
  84. pmc Postresection CA 19-9 predicts overall survival in patients with pancreatic cancer treated with adjuvant chemoradiation: a prospective validation by RTOG 9704
    Adam C Berger
    Thomas Jefferson University, Philadelphia, PA, USA
    J Clin Oncol 26:5918-22. 2008
    ..CA 19-9 is an important tumor marker in patients with pancreatic adenocarcinoma. A secondary end point of Radiation Therapy Oncology Group trial 9704 was prospective evaluation of the ability of postresectional CA 19-9 to predict survival...
  85. pmc Patterns and correlates of adjuvant radiotherapy receipt after lumpectomy and after mastectomy for breast cancer
    Reshma Jagsi
    Department of Radiation Oncology, University of Michigan, UHB2C490, SPC 5010, 1500 E Medical Center Dr, Ann Arbor, MI 48109 5010, USA
    J Clin Oncol 28:2396-403. 2010
    ..To use patient self-report to provide more valid estimates of whether radiotherapy (RT) is underutilized than possible with registry data, as well as to evaluate for disparities and the influence of preferences and provider interactions...
  86. ncbi [Innovation in adjuvant radiotherapy for breast cancer: new biologic parameters, a perspective for treatment tailoring]
    Y Belkacemi
    service d oncologie radiothérapie, Hopital Henri Mondor, APHP, 54, Avenue du Marechal de Lattre de Tassigny, 94000 Creteil, France
    Bull Cancer 96:111-21. 2009
    ....
  87. ncbi Prognostic significance of CD24 protein expression in patients treated with adjuvant radiotherapy after radical hysterectomy for cervical squamous cell carcinoma
    Chang Ohk Sung
    Department of Pathology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Radiother Oncol 95:359-64. 2010
    ....
  88. ncbi The impact of adjuvant radiotherapy on survival in T1-2N1 squamous cell carcinoma of the oral cavity
    Mark G Shrime
    Department of Otolaryngology Head and Neck SurgerySurgery Surgical Oncology, University Health Network, Princess Margaret Hospital, USA
    Arch Otolaryngol Head Neck Surg 136:225-8. 2010
    ..To evaluate the survival impact of postoperative radiation therapy (RT) in patients with early T stage (T1-2) oral cavity squamous cell carcinoma (OCSCC) and a single positive lymph node...
  89. ncbi Adjuvant radiotherapy in stage IV diffuse large cell lymphoma improves outcome
    Agustin Avilés
    Oncology Hospital, National Medical Center, IMSS, Mexico, DF, Mexico
    Leuk Lymphoma 45:1385-9. 2004
    The role of adjuvant radiotherapy to sites of nodal bulky disease in patients with aggressive diffuse large cell lymphoma (DLCL), and stage IV remain undefined...
  90. ncbi Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity
    J C Yang
    Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Clin Oncol 16:197-203. 1998
    ..This randomized, prospective study assesses the impact of postoperative external-beam radiation therapy on local recurrence (LR), overall survival (OS), and quality of life after limb-sparing resection of extremity sarcomas...
  91. ncbi Adjuvant radiotherapy for gastric cancer: A dosimetric comparison of 3-dimensional conformal radiotherapy, tomotherapy and conventional intensity modulated radiotherapy treatment plans
    Max Dahele
    Department of Radiation Oncology, Odette Cancer Centre, Toronto, Ontario, Canada
    Med Dosim 35:115-21. 2010
    ..Both irradiate large volumes of normal tissue to low doses. Additional studies are needed to demonstrate the clinical impact of these technologies...
  92. ncbi Adjuvant radiotherapy after modified Ivor-Lewis esophagectomy: can it prevent lymph node recurrence of the mid-thoracic esophageal carcinoma?
    Gang Chen
    Department of Thoracic Surgery, Provincial Hospital affiliated to Shandong University, Jinan, China
    Ann Thorac Surg 87:1697-702. 2009
    ..This study was undertaken to evaluate the effectiveness of adjuvant radiotherapy after modified Ivor-Lewis esophagectomy on preventing lymph node recurrence of the mid-thoracic esophageal ..
  93. ncbi Does adjuvant radiotherapy suppress liver regeneration after partial hepatectomy?
    Jin Hwa Choi
    Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea
    Int J Radiat Oncol Biol Phys 74:67-72. 2009
    To analyze the influence of the adjuvant radiotherapy (RT) on the liver regeneration and liver function after partial hepatectomy (PH).
  94. ncbi Integration of novel agents into combined-modality treatment for rectal cancer patients
    Claus Rodel
    Department of Radiation Therapy, University of Frankfurt Main, Germany
    Strahlenther Onkol 183:227-35. 2007
    ..The challenge is to integrate more effective systemic therapy into combined-modality programs...
  95. ncbi Adjuvant radiotherapy in the treatment of pediatric myxopapillary ependymomas
    Hani Al-Halabi
    Department of Radiation Oncology, McGill University Health Centre Montreal General Hospital, Montreal, Quebec, Canada
    Pediatr Blood Cancer 55:639-43. 2010
    ..Assess the role of radiotherapy (RT) in the management of primary and recurrent myxopapillary ependymoma (MPE)...
  96. ncbi Long-term follow-up after transoral laser microsurgery and adjuvant radiotherapy for advanced recurrent squamous cell carcinoma of the head and neck
    Hans Christiansen
    Department of Radiotherapy, University of Gottingen, Gottingen, Germany, and Départmentde Cancérologie, Hopital Morvan, Centre Hospitalier Universitaire de Brest, France
    Int J Radiat Oncol Biol Phys 65:1067-74. 2006
    The aim of this study was to evaluate the efficacy of adjuvant radiotherapy after transoral laser microsurgery for advanced recurrent head-and-neck squamous cell carcinoma (HNSCC).
  97. ncbi Hypofractionated adjuvant radiotherapy with helical tomotherapy after radical prostatectomy: planning data and toxicity results of a Phase I-II study
    Cesare Cozzarini
    Department of Radiotherapy, and Scientifc Institute H San Raffaele, Milan, Italy
    Radiother Oncol 88:26-33. 2008
    To report on planning and toxicity findings of hypofractionated adjuvant radiotherapy with helical Tomotherapy (HTT) after radical prostatectomy (RP) for prostate carcinoma (pCa).
  98. pmc Effectiveness of adjuvant radiotherapy in patients with oropharyngeal and floor of mouth squamous cell carcinoma and concomitant histological verification of singular ipsilateral cervical lymph node metastasis (pN1-state)--a prospective multicenter random
    Maximilian Moergel
    Department of Oral and Maxillofacial Surgery, University of Mainz, Medical Center, Augustusplatz 2, D 55131 Mainz, Germany
    Trials 10:118. 2009
    ....
  99. ncbi Changes in Mcl-1 expression in rectal cancer in relation to neo-adjuvant radiotherapy
    Herbert Ulrich-Pur
    Department of Internal Medicine I, Vienna University Medical School, Vienna, Austria
    Wien Klin Wochenschr 117:136-40. 2005
    ..Expression of the antiapoptotic protein myeloid cell leukemia-1 (Mcl-1) may be disordered in malignancies of the rectum. High levels of Mcl-1 may correlate with unfavourable clinical outcome...
  100. ncbi Adjuvant radiotherapy following radical prostatectomy for pathologic T3 or margin-positive prostate cancer: a systematic review and meta-analysis
    Scott C Morgan
    The Ottawa Hospital Cancer Centre, Ottawa, Ont, Canada
    Radiother Oncol 88:1-9. 2008
    ..The optimal postoperative management of such patients is undefined. Therapeutic alternatives include adjuvant radiotherapy (RT) or active surveillance.
  101. ncbi Adjuvant radiotherapy following total mesorectal excision for stage IIA rectal cancer: is it beneficial?
    Jin Soo Kim
    Department of Surgery, Chungnam National University Hospital, Daejeon, Korea
    Int J Colorectal Dis 25:1103-10. 2010
    The benefit of adjuvant radiotherapy in patients with stage IIA (T3N0) rectal cancer following total mesorectal excision (TME) is controversial...

Research Grants67

  1. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    ..The standard of care for newly diagnosed GBM is surgical resection followed by adjuvant radiotherapy and temozolomide (TMZ) chemotherapy...
  2. Genome Wide Discovery of Molecular Alterations in Salivary Gland Tumors
    Nishant Agrawal; Fiscal Year: 2013
    ..Treatment is primarily surgical followed by adjuvant radiotherapy based on certain pathologic features...
  3. Ap endo as a predictor of response to glioma therapy
    JOHN SILBER; Fiscal Year: 2006
    ..is a strong, inverse correlation of Ap endo activity with time to tumor progression (TTP) following either adjuvant radiotherapy or alkylator therapy...
  4. Osteoporosis Prevention in Early Stage Breast Cancer
    Dawn Hershman; Fiscal Year: 2006
    ..abstract_text> ..
  5. IMRT in the Treatment of Node-Positive Breast Cancer
    Lori Pierce; Fiscal Year: 2006
    ..3) Study 60 patients treated with either the best delivery-optimized motion corrected plan from Aim 2 or PWTF and compare plans using heart and lung metrics. ..
  6. IMRT in the Treatment of Node-Positive Breast Cancer
    Lori Pierce; Fiscal Year: 2003
    ..4) Determine the effect of motion on static IMRT and PWTF dose distributions, and then correct/adjust for motion to determine the best delivery-optimized plan. ..
  7. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2008
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  8. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2009
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  9. Mentored Patient-Oriented Research Career Development Award
    Jacqueline Jonklaas; Fiscal Year: 2006
    ..A new sustained release product, which results in steady triiodothyronine levels, will furnish more physiologic replacement. This will be tested against treatment with levothyroxine, and levothyroxine and triiodothyronine. ..
  10. PREDICTORS OF RELAPSE TO SMOKING IN LUNG CANCER
    Mario Schootman; Fiscal Year: 2005
    ..abstract_text> ..
  11. Screening for Ovarian Cancer: Psychobehavioral Outcomes
    Michael Andrykowski; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  12. Gis, multilevel modeling and breast cancer screening
    Mario Schootman; Fiscal Year: 2002
    ..Few studies focusing on breast cancer screening have taken this approach, which we, and others feel is warranted. ..
  13. PKC Beta Inhibition With Gemcitabine And Radiation In Pancreas Cancer
    Edgar Ben Josef; Fiscal Year: 2008
    ..Based on its scientific merit and our institutional track record in translational research in pancreas cancer, we feel it is highly likely that this research will prove beneficial. [unreadable] [unreadable] [unreadable]..
  14. Functional Mechanisms of Antibody Inhibition of HIV-1
    Marshall Posner; Fiscal Year: 2008
    ..Long-term objectives will be to select constructs from in vitro testing for further testing in non-human primate models of prevention and therapeutics. ..
  15. Presurgery Hypnosis in Breast Cancer: Benefits Analysis
    Guy Montgomery; Fiscal Year: 2006
    ..Mediators and moderators (e.g., hypnotizability) of hypnosis effects will be determined, as well as long-term side benefits of the intervention. ..
  16. Mammographic Density in a Multi-Ethnic Cohort
    Laurel Habel; Fiscal Year: 2005
    ..abstract_text> ..
  17. Multivalent Dendritic Cell Vaccine in Pancreas Cancer
    David Linehan; Fiscal Year: 2006
    ..3) Test efficacy of peptide-specific CTL generation and toxicity in an HLA-A2 transgenic murine model (4) Conduct a phase I clinical trial of a multivalent DC vaccine in pancreas cancer patients. ..
  18. Changes in Functional Status Across Therapy for Primary Glioma
    Lee Jones; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2007
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  20. Insulin Resistance and Breast Cancer Outcome
    Abenaa Brewster; Fiscal Year: 2007
    ..This information will be useful in identifying women who may benefit from interventions to decrease insulin resistance as part of their breast cancer care. [unreadable] [unreadable] [unreadable]..
  21. Rapamycin as an Antineoplastic Agent
    Ezra Cohen; Fiscal Year: 2006
    ..At the conclusion of the trial RAPA toxicity and effect on p-S6K will be defined over a range of doses as well as the MTD for use in future studies that will develop this agent. ..
  22. Carotid Artery Disease Following Neck Irradiation in Ch*
    Kathleen Meeske; Fiscal Year: 2006
    ..abstract_text> ..
  23. PATTERNS CARE FOR CANCER PATIENTS AT END OF LIFE
    Ellen McCarthy; Fiscal Year: 2002
    ..Information obtained from the study can be used to improve the quality of care for patients at the end of life and help to determine the nature and amount of resources that might be required to meet patients' needs. ..
  24. AIDS MALIGNANCY CONSORTIUM
    Joseph Sparano; Fiscal Year: 2005
    ..abstract_text> ..
  25. How Health Insurance Status Affects Persons with Disabilities
    Lisa Iezzoni; Fiscal Year: 2007
    ..This goal addresses the objectives of the Agency for Healthcare Research and Quality, which has identified persons with disabilities as one of its priority populations. [unreadable] [unreadable] [unreadable]..
  26. Cancer Care and Outcomes for Disabled Medicare Patients
    Lisa Iezzoni; Fiscal Year: 2006
    ..These findings may suggest areas where more attention is needed, such as increasing cancer screening among disabled Medicare recipients or rethinking initial treatment strategies. ..
  27. Extracellular matrix and protease markers of malignant thyroid neoplasm
    Electron Kebebew; Fiscal Year: 2007
    ..We will use these results to design a multicenter clinical trial evaluating the diagnostic and prognostic value of ECM1 and TMPRSS4 expression in patients with thyroid neoplasm. [unreadable] [unreadable] [unreadable]..
  28. Psychological and Behavioral Impact of Cancer Screening
    Michael Andrykowski; Fiscal Year: 2008
    ..The overall goal of the training program is to prepare trainees for careers as independent investigators in behavioral oncology. ..
  29. PREMATURE MENOPAUSE IN SURVIVORS OF CHILDHOOD CANCER
    Charles Sklar; Fiscal Year: 2002
    ..The large size of the study population, the heterogeneity of diagnoses and exposures, combined with the extensive treatment data, will allow assessment of interaction between the major risk factors of interest. ..
  30. HYPOXIC IMAGING GUIDED INTENSITY MODULATED RADIOTHERAPY
    KS CLIFFORD CHAO; Fiscal Year: 2003
    ..They will test the hypothesis by performing multiple Cu-60 ATSM PET scans during the course of irradiation to understand the spatial evolution of hypoxic tumor. ..
  31. HUMAN MONOCLONAL ANTIBODIES TO STUDY AND TREAT HIV
    Marshall Posner; Fiscal Year: 2003
    ..We will also study long term non-progressors and early progressors to assess the relationship of antibody to intact PI virions to control of disease as a basis for larger more powerful evaluations. ..
  32. Acupuncture for shoulder syndrome after ca surgery
    David Pfister; Fiscal Year: 2004
    ..Data: Standard deviations, mean of control group, correlation between and within baseline and follow-up measures. ..
  33. CARDINAL BERNARDIN CANCER CENTER, LOYOLA UNIVERSITY
    Patrick Stiff; Fiscal Year: 2002
    ..At the completion of this grant, the Cardinal Bernardin Cancer Center plans to be positioned to successfully apply for a P-30 Cancer Center Support Grant. ..
  34. THERAPY OF HEPATIC METASTASES FROM COLORECTAL CARCINOMA
    Nancy Kemeny; Fiscal Year: 2001
    ..Cryosurgery and newer hepatic arterial therapies are therapeutic modalities that can be used in patients in whom liver resection is impossible. ..
  35. PERSONS WITH DISABILITIES: QUALITY OF CARE/SERVICE USE
    Lisa Iezzoni; Fiscal Year: 2001
    ..Given that roughly 49 million Americans have a disabling condition, addressing concerns about their quality of care is essential. ..
  36. PET IMAGING IN MULTIMODALITY MANAGEMENT OF RECTAL CANCER
    Jose Guillem; Fiscal Year: 2001
    b>Adjuvant radiotherapy and chemotherapy (RT/chemo) is the standard of care for locally advanced rectal cancer patients...
  37. Postmarketing Surveillance of Toxicities Associated with Cancer Chemotherapy
    Xianglin Du; Fiscal Year: 2010
    ..This database is especially unique for studying cancer chemotherapy and its toxicity because chemotherapy is among the few drugs that are covered by Medicare for past several decades. ..
  38. RESEARCH TRAINING IN MEDICAL BEHAVIORAL SCIENCE
    Michael Andrykowski; Fiscal Year: 2004
    ..Postdoctoral fellows will address each of the same elements with an intensity and emphasis that is tailored to their individual needs and prior experience. ..
  39. Developing a Tool to Improve the Quality of Breast Cancer Treatment Decisions
    Sarah Hawley; Fiscal Year: 2008
    ..This project has direct relevance for improving the quality of cancer care for all women. [unreadable] [unreadable] [unreadable]..
  40. Racial Differences in CAM for Common Medical Conditions
    Ellen McCarthy; Fiscal Year: 2005
    ..Findings will provide a fundamental understanding of CAM in minority populations that will be used to plan for future studies. ..
  41. Molecular Analysis-Directed Individualised Therapy in Ad
    George Simon; Fiscal Year: 2005
    ..Patients will be followed till death and survival curves will be generated. ..
  42. Functional Infrared Imaging Predicts Radiation Mucositis
    Ezra Cohen; Fiscal Year: 2008
    ..Such a tool would have wide applicability in this patient population and would have tremendous impact on their treatment. [unreadable] [unreadable] [unreadable]..
  43. Evaluation of Chemotherapy Claims for Breast Cancer
    Xianglin Du; Fiscal Year: 2003
    ....
  44. Indomethacin and p38 Regulating AP-1 In Heat Shock
    Jacob Locke; Fiscal Year: 2004
    ..abstract_text> ..
  45. CANCER COURSES FOR NURSES WORKING WITH MINORITY GROUPS
    Sandra Millon Underwood; Fiscal Year: 2004
    ..to be tested will focus on the degree to which the program facilitates the integration of didactic content, thoughtful discussions, clinical/laboratory experiences, related literature, evidence-based information obtained from the ..
  46. CUTANEOUS ONCOLOGY
    Madeleine Duvic; Fiscal Year: 2004
    ..Young physicians and students who receive advanced training in the proper detection, prevention, and treatment of skin cancers will be a resource and may improve outcomes for patients of the future. ..
  47. GIS and Breast Cancer Screening in Saint Louis
    Mario Schootman; Fiscal Year: 2004
    ..abstract_text> ..
  48. MECHANISMS OF TRANSFORMATION OF HEMATOPOIETIC CELLS
    JAMES MC CUBREY; Fiscal Year: 2001
    ..An understanding of how these signal transduction and apoptotic pathways impinge upon one another will further our comprehension of the consequences of abnormal oncogene activation and tumor progression. ..
  49. Stabilized Helical Peptides as Coactivators Antagonists
    Federico Bernal; Fiscal Year: 2006
    ..Moreover, it will give further insight into the role of coactivator peptides in the activation of a specific gene in a particular cell type. ..
  50. Primary Care Colorectal Ca Screening Surveillance System
    Richard Hoffman; Fiscal Year: 2005
    ..abstract_text> ..
  51. Radiotherapy Quality and Outcomes in Prostate Cancer
    JUSTIN BEKELMAN; Fiscal Year: 2006
    ..Furthermore, we hypothesize that higher radiotherapy quality performance is associated with longer event-free survival and lower morbidity. [unreadable] [unreadable] [unreadable]..
  52. Presurgery Hypnosis--Benefits Analysis in Breast Cancer
    Guy Montgomery; Fiscal Year: 2003
    ..The possible mediational role of these factors in hypnosis effects will be examined will classic statistical approaches. ..
  53. CHILDRENS NATIONAL MEDICAL CENTER
    Roger Packer; Fiscal Year: 2003
    ....
  54. Polarity Therapy for Cancer-Related Fatigue
    Karen Mustian; Fiscal Year: 2007
    ..Anticipated results could have clinical, methodological, and theoretical application in the treatment and study of CRF, a symptom affecting most cancer patients during radiation therapy. ..
  55. Geography of Amputations Among African Americans
    Mario Schootman; Fiscal Year: 2005
    ..abstract_text> ..
  56. Oncology Clinical Trial Accrual Study
    ANNEKE SCHROEN; Fiscal Year: 2009
    ....
  57. Benefits and Burdens of Screening Oldest-old Women: the Case of Mammography
    MARA SCHONBERG; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  58. Mammography Screening Decisions in the Elderly
    MARA SCHONBERG; Fiscal Year: 2005
    ..This is the first study to explore very elderly women's approach to decisions about screening mammography. ..
  59. TARGETING BREAST CANCER WITH SMALL LIGANDS
    David Krag; Fiscal Year: 2006
    ..3) Use the structure-based, homologous analog and biased library approach to make educated designs to increase the affinity of the Grb7 ligands ..
  60. CANCER AND LEUKEMIA GROUP B
    David Sugarbaker; Fiscal Year: 2002
    ..Three stages of group development are described: (1) surgeon recruitment phase; (2) patient recruitment phase (educational activities about adjuvant therapy trials. etc.); and (3) protocol development phase (intellectual activities). ..
  61. Targeted Enzymes for Prodrug Therapy
    David Krag; Fiscal Year: 2007
    ..Successful completion of these experiments will result in demonstration of novel targeted effector molecules that bind selectively to tumors and activate cytotoxic prodrugs. ..
  62. In Vivo Selection of Ligands for Targeted Therapy
    David Krag; Fiscal Year: 2003
    ..Successful completion of this clinical study will result in demonstration of a satisfactory safety profile and short peptides that bind selectively to tumor tissue. ..
  63. NABTT-Consortium Therapeutic Studies of CNS Malignancies
    Stuart Grossman; Fiscal Year: 2008
    ..abstract_text> ..
  64. The Role of GDF-15 in Organ Injury
    Leonidas Koniaris; Fiscal Year: 2005
    ..The completion of this mentored research training will further the candidate?s goal of applying bench-derived scientific discovery to the treatment of surgical disease as an independent investigator. ..
  65. Increasing Functional Liver Mass in Health and Disease
    Leonidas Koniaris; Fiscal Year: 2005
    ..2) Determine the extent to which and mechanisms by which co-administrating HCF and Follistatin along with IL-6 facilitates the liver growth response and reduces IL-6 associated toxicity. ..
  66. Hospice Pain Control: Developing an Opioid Order Sheet
    Barbara Murphy; Fiscal Year: 2006
    ..Once the modifications lave been made, we will conduct a pilot study to assess feasibility, utility and efficacy of the order sheet in the outpatient hospice setting. [unreadable] [unreadable]..
  67. An Epidemiologic Study of Lymph Node Evaluation in Colorectal Cancer Patients
    Beth Virnig; Fiscal Year: 2007
    ..Most CRC patient in the U.S. do not have an adequate node evaluation. This research will identify factors that affect the adequacy of lymph node staging in CRC so that improvements can be made. [unreadable] [unreadable]..