coronary atherectomy

Summary

Summary: Percutaneous transluminal procedure for removing atheromatous plaque from the coronary arteries. Both directional (for removing focal atheromas) and rotational (for removing concentric atheromatous plaque) atherectomy devices have been used.

Top Publications

  1. ncbi A novel approach using rotational atherectomy for protruded stent struts getting in the way of the guiding catheter at the ostial left main trunk
    Shigenori Ito
    Division of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Japan
    J Invasive Cardiol 17:564-8. 2005
  2. ncbi Increased expression of interleukin-10 in unstable plaque obtained by directional coronary atherectomy
    Kensaku Nishihira
    First Department of Internal Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Eur Heart J 27:1685-9. 2006
  3. ncbi Intravascular ultrasound-guided directional coronary atherectomy for unprotected left main coronary stenoses with distal bifurcation involvement
    Fang Bin Hu
    Department of Cardiology, Shiga Medical Center for Adults, Moriyama, Japan
    Am J Cardiol 92:936-40. 2003
  4. ncbi Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2
    Hironosuke Sakamoto
    Department of General Medicine, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Cardiology 100:80-5. 2003
  5. ncbi Angiotensin-converting enzyme insertion/deletion polymorphism and risk of restenosis after directional coronary atherectomy followed by stent implantation
    Umberto Canosi
    Divisione di Cardiologia IRCCS Policlinico San Matteo, Piazza Golgi 2, 27100 Pavia, Italy
    Thromb Haemost 91:795-800. 2004
  6. ncbi Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris: important role of NAD(P)H oxidase
    Hiroshi Azumi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 22:1838-44. 2002
  7. ncbi Association between prior cytomegalovirus infection and the risk of restenosis after coronary atherectomy
    Y F Zhou
    Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1650, USA
    N Engl J Med 335:624-30. 1996
  8. ncbi Directional coronary atherectomy plus stent implantation vs. left internal mammary artery bypass grafting for isolated proximal stenosis of the left anterior descending coronary artery
    Nedy Brambilla
    Division of Cardiology, IRCCS Policlinico San Matteo, Pavia, Italy
    Catheter Cardiovasc Interv 64:45-52. 2005
  9. ncbi Relation of matrix-metalloproteinase 3 found in coronary lesion samples retrieved by directional coronary atherectomy to intravascular ultrasound observations on coronary remodeling
    Paul Schoenhagen
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 89:1354-9. 2002
  10. ncbi Involvement of C-reactive protein obtained by directional coronary atherectomy in plaque instability and developing restenosis in patients with stable or unstable angina pectoris
    Tetsunori Ishikawa
    First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Am J Cardiol 91:287-92. 2003

Research Grants

Detail Information

Publications204 found, 100 shown here

  1. ncbi A novel approach using rotational atherectomy for protruded stent struts getting in the way of the guiding catheter at the ostial left main trunk
    Shigenori Ito
    Division of Cardiovascular Medicine, Toyohashi Heart Center, Toyohashi, Japan
    J Invasive Cardiol 17:564-8. 2005
  2. ncbi Increased expression of interleukin-10 in unstable plaque obtained by directional coronary atherectomy
    Kensaku Nishihira
    First Department of Internal Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Eur Heart J 27:1685-9. 2006
    ..The present study investigates the expression and localization of interleukin (IL)-10, an important anti-inflammatory cytokine, in atherectomy specimens from patients with stable and unstable angina...
  3. ncbi Intravascular ultrasound-guided directional coronary atherectomy for unprotected left main coronary stenoses with distal bifurcation involvement
    Fang Bin Hu
    Department of Cardiology, Shiga Medical Center for Adults, Moriyama, Japan
    Am J Cardiol 92:936-40. 2003
    ..Optimal debulking by directional coronary atherectomy (DCA) with intravascular ultrasound (IVUS) guidance may be effective in this complex lesion subset, but ..
  4. ncbi Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2
    Hironosuke Sakamoto
    Department of General Medicine, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Cardiology 100:80-5. 2003
    ..Immunostaining for KLF5 was more common in specimens with outgrowth (89 vs. 20%, p < 0.01). These data suggest that the number of activated SMCs in lesions may determine in vitro outgrowth and also affect the time to restenosis...
  5. ncbi Angiotensin-converting enzyme insertion/deletion polymorphism and risk of restenosis after directional coronary atherectomy followed by stent implantation
    Umberto Canosi
    Divisione di Cardiologia IRCCS Policlinico San Matteo, Piazza Golgi 2, 27100 Pavia, Italy
    Thromb Haemost 91:795-800. 2004
    ..Our results indicate that ACE I/D polymorphism does not influence the risk of developing angiographic restenosis in patients undergoing DCA followed by stent implantation...
  6. ncbi Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris: important role of NAD(P)H oxidase
    Hiroshi Azumi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 22:1838-44. 2002
    ..For this aim, the expression of p22(phox), the distribution of oxidized low density lipoprotein (LDL), and the generation of ROS in directional coronary atherectomy (DCA) specimens were examined.
  7. ncbi Association between prior cytomegalovirus infection and the risk of restenosis after coronary atherectomy
    Y F Zhou
    Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1650, USA
    N Engl J Med 335:624-30. 1996
    ..Recently, it has been found that cytomegalovirus (CMV) DNA is present in restenotic lesions from atherectomy specimens. This and other evidence suggest that CMV may have a role in the process of restenosis...
  8. ncbi Directional coronary atherectomy plus stent implantation vs. left internal mammary artery bypass grafting for isolated proximal stenosis of the left anterior descending coronary artery
    Nedy Brambilla
    Division of Cardiology, IRCCS Policlinico San Matteo, Pavia, Italy
    Catheter Cardiovasc Interv 64:45-52. 2005
    ..or = 30 days) clinical outcomes of left internal mammary artery bypass grafting (LIMA-LAD) and directional coronary atherectomy plus stent implantation (DCA + stent) in the treatment of isolated proximal left anterior descending ..
  9. ncbi Relation of matrix-metalloproteinase 3 found in coronary lesion samples retrieved by directional coronary atherectomy to intravascular ultrasound observations on coronary remodeling
    Paul Schoenhagen
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 89:1354-9. 2002
    ..04; p = 0.053 after adjustment for gender). Thus, in this in vivo intravascular ultrasound and histologic study, increased cell-associated MMP-3 staining was associated with positive arterial remodeling...
  10. ncbi Involvement of C-reactive protein obtained by directional coronary atherectomy in plaque instability and developing restenosis in patients with stable or unstable angina pectoris
    Tetsunori Ishikawa
    First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Am J Cardiol 91:287-92. 2003
    ..lesions is related to coronary plaque instability and whether it could affect the outcome of directional coronary atherectomy (DCA)...
  11. ncbi Sirolimus-eluting stents and calcified coronary lesions: clinical outcomes of patients treated with and without rotational atherectomy
    Leonardo C Clavijo
    Division of Cardiology, Washington Hospital Center, Washington, DC 20010, USA
    Catheter Cardiovasc Interv 68:873-8. 2006
    ..Lesions requiring rotational atherectomy to facilitate dilation and stenting had similar outcomes after SES implantation to those that could be stented without the need for rotablator...
  12. ncbi Rotablator versus cutting balloon for the treatment of long in-stent restenoses
    Peter Braun
    Department of Cardiology and Angiology, Duosburg Heart Center, Gerrickstr 21, 47137 Duisburg, Germany
    J Invasive Cardiol 14:291-6. 2002
    ..This study was designed to retrospectively assess rotational coronary atherectomy (Rotablator , or RA) and the Cutting Balloon (CB) with respect to the rate of restenoses after 6 months, ..
  13. ncbi Influence of device selection on angiographic outcomes for the treatment of in-stent restenosis. A sub analysis from the Washington Radiation for In-Stent restenosis Trial (WRIST)
    Marco Zimarino
    Vascular Brachytherapy Institute, Cardiology Research Institute, Washington Hospital Center, Washington, DC, USA
    Ital Heart J 3:256-62. 2002
    ..The aim of this study was to evaluate the influence of device selection on ICB for the treatment of instant restenosis...
  14. ncbi Effect of plaque debulking before stent implantation on in-stent neointimal proliferation: a serial 3-dimensional intravascular ultrasound study
    Yoshihiro Takeda
    Department of Cardiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka City, Japan
    Am Heart J 146:175-82. 2003
    ..We report on volumetric assessments of in-stent neointimal formation with 3-dimensional IVUS analysis, comparing directional coronary atherectomy (DCA) plus stenting (DCA/stenting) to stenting without DCA.
  15. ncbi Debulking of chronic coronary total occlusions with rotational or directional atherectomy before stenting: Final results of DOCTORS study
    Etsuo Tsuchikane
    Department of Cardiology, Toyohashi Heart Center, 21 1, Gobudori, Ohyama, Toyohashi, Aichi 441 8530, Japan
    Int J Cardiol 125:397-403. 2008
    ..To evaluate the safety and efficacy of pre-stent plaque debulking strategy for percutaneous coronary intervention for CTO...
  16. ncbi Benefits of cutting balloon before stenting
    David G Rizik
    Scottsdale Heart Group at Scottsdale Healthcare Hospital, Scottsdale, AZ 85258, USA
    J Invasive Cardiol 15:624-8. 2003
    ..The objectives of this study were to prospectively evaluate the safety and feasibility of pretreating the culprit coronary artery lesion with cutting balloon (CB) angioplasty prior to coronary stent implantation...
  17. ncbi Predictive value of preintervention C-reactive protein on clinical outcome after directional coronary atherectomy followed by stent implantation
    Giampaolo Niccoli
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    Cardiovasc Revasc Med 8:156-60. 2007
    ..Directional coronary atherectomy (DCA), by reducing residual plaque burden and restenosis, has been shown to improve clinical outcome after ..
  18. ncbi Promising efficacy of primary gradual and prolonged balloon angioplasty in small coronary arteries: a randomized comparison with cutting balloon angioplasty and conventional balloon angioplasty
    Hisashi Umeda
    Division of Cardiology, Aichi Prefuctural Owari Hospital, Ichinomiya, Japan
    Am Heart J 147:E4. 2004
    ..The aim of this study was to assess the clinical and angiographic benefits of primary GPBA with a perfusion balloon in small coronary arteries, as compared with cutting balloon angioplasty (CBA) and POBA...
  19. ncbi Percutaneous treatment of focal vs. diffuse in-stent restenosis: a prospective randomized comparison of conventional therapies
    Michael Ragosta
    Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Catheter Cardiovasc Interv 61:344-9. 2004
    ..Only the presence of diffuse ISR was an independent predictor of MACE at 9 months. Thus, focal ISR has a low rate of MACE compared to diffuse ISR, which carries a high event rate regardless of treatment employed...
  20. ncbi Angiographic outcome after intracoronary X-Sizer helical atherectomy and thrombectomy: first use in humans
    On Hing Kwok
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Catheter Cardiovasc Interv 55:133-9. 2002
    ..A large-scale randomized phase II clinical trial is underway to determine the ultimate safety and efficacy of this device in thrombo-occlusive native coronary arteries and saphenous vein grafts...
  21. ncbi Rotational atherectomy does not reduce recurrent in-stent restenosis: results of the angioplasty versus rotational atherectomy for treatment of diffuse in-stent restenosis trial (ARTIST)
    Juergen vom Dahl
    Medizinische Klinik I, Universitatsklinikum, Rheinisch Westfaelische Technische Hochschule Aachen, Germany
    Circulation 105:583-8. 2002
    ....
  22. ncbi Incidence, mechanism, predictors, and long-term prognosis of late stent malapposition after bare-metal stent implantation
    Myeong Ki Hong
    Department of Medicine, University of Ulsan College of Medicine, Cardiac Center, Asan Medical Center, Seoul, Korea
    Circulation 109:881-6. 2004
    ..Predictors and long-term prognosis of late stent malapposition (LSM) after bare-metal stent (BMS) implantation are unknown...
  23. ncbi Initial experience with a new 8 French-compatible directional atherectomy catheter: immediate and mid-term results
    Dejan Orlic
    Catheterization Laboratory, Columbus Hospital, Milan, Italy
    Catheter Cardiovasc Interv 60:159-66. 2003
    ..Plaque debulking with the FHT catheter can be performed safely and effectively in relatively small vessels and complex lesions located in mid-distal artery segments with 6-month clinical outcome similar to prior atherectomy devices...
  24. ncbi Influence of various percutaneous coronary interventional devices on postinterventional luminal shape and plaque surface characteristics as determined by intravascular ultrasound
    Berkten Berkalp
    Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 91:1269-72. 2003
  25. ncbi Vulnerable plaque detection by temperature heterogeneity measured with a guidewire system: clinical, intravascular ultrasound and histopathologic correlates
    Marco Wainstein
    Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    J Invasive Cardiol 19:49-54. 2007
    ..Further studies will determine the predictive value of thermography or other techniques for assessing plaque composition and risk through noninvasive or invasive means...
  26. ncbi Successful nonsurgical treatment of left main stem perforation by sacrifice of the LAD
    Lowell F Satler
    Division of Cardiology, Washington Hospital Center, Washington, DC
    Catheter Cardiovasc Interv 69:850-1. 2007
  27. ncbi Safety and efficacy of a novel device for treatment of thrombotic and atherosclerotic lesions in native coronary arteries and saphenous vein grafts: results from the multicenter X-Sizer for treatment of thrombus and atherosclerosis in coronary application
    Gregg W Stone
    The Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, New York 10021, USA
    Catheter Cardiovasc Interv 58:419-27. 2003
    ..0%, and any MACE in 6.0%. We conclude that the use of the X-Sizer prior to percutaneous intervention is safe in high-risk vein grafts and thrombotic lesions and results in a low rate of adverse events compared to historical controls...
  28. ncbi Successful nonsurgical treatment of left main stem perforation by sacrifice of the LAD
    Reto Gamma
    Department of Cardiology, King s College Hospital, Denmark Hill, London, United Kingdom
    Catheter Cardiovasc Interv 69:845-9. 2007
    ..The management and outcome of this potentially fatal complication are discussed...
  29. ncbi Drug-eluting stents versus bare metal stents following rotational atherectomy for heavily calcified coronary lesions: late angiographic and clinical follow-up results
    Ahmed A Khattab
    Herz Kreislauf Zentrum Segeberger Kliniken GmbH, Bad Segeberg, Germany
    J Interv Cardiol 20:100-6. 2007
    ..To study the effectiveness of drug-eluting stents following rotablation of severely calcified lesions...
  30. pmc Histopathology of coronary in-stent restenosis following gamma brachytherapy
    H C Lowe
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02144 2696, USA
    Heart 89:11-3. 2003
    ..The recurrent ISR was treated with directional coronary atherectomy; the histopathology of this directional coronary atherectomy specimen is discussed...
  31. ncbi Mechanism of late in-stent restenosis after implantation of a paclitaxel derivate-eluting polymer stent system in humans
    Renu Virmani
    Catheterization Laboratories, Ospedale San Raffaele and Emo Centro Cuore Columbus, Milan, Italy
    Circulation 106:2649-51. 2002
    ..This study presents the histological findings of atherectomy specimens from a subset of these patients receiving implants...
  32. ncbi Angiographic analysis of the angioplasty versus rotational atherectomy for the treatment of diffuse in-stent restenosis trial (ARTIST)
    Ulrich Dietz
    University Hospital, Mainz, Germany
    Am J Cardiol 90:843-7. 2002
    ..Thus, PTCA and PTCR of diffuse ISRs yield comparable acute angiographic results. The recurrence of a restenosis is higher after PTCR than after PTCA...
  33. ncbi Interventional therapy for coronary artery disease
    Pinak B Shah
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:791-6. 2002
  34. pmc Clinical and angiographic outcome of directional atherectomy followed by stent implantation in de novo lesions located at the ostium of the left anterior descending coronary artery
    F Airoldi
    EMO Centro Cuore, Columbus Clinic and Interventional Cardiology Unit, San Raffaele Hospital IRCCS, Milan, Italy
    Heart 89:1050-4. 2003
    ....
  35. ncbi Insufficient tissue ablation by rotational atherectomy leads to worse long-term results in comparison with balloon angioplasty alone for the treatment of diffuse in-stent restenosis: insights from the intravascular ultrasound substudy of the ARTIST random
    Philipp K Haager
    Medizinische Klinik I, Universitätsklinik Aachen, Aachen, Germany
    Catheter Cardiovasc Interv 60:25-31. 2003
    ..Neointimal ablation by RA has only minor effects. Low-pressure PTCA does not prevent recurrent tissue growth and failed for treatment of ISR due to insufficient stent expansion...
  36. ncbi Images in cardiovascular medicine. Stent inflammation: stent footprint in restenotic tissue retrieved by directional atherectomy
    Martijn Meuwissen
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 106:1176-7. 2002
  37. ncbi Results and long-term predictors of adverse clinical events after elective percutaneous interventions on unprotected left main coronary artery
    Takuro Takagi
    EMO Centro Cuore Columbus, Milan, Italy
    Circulation 106:698-702. 2002
    ..The safety and efficacy of percutaneous coronary intervention of de novo lesions in unprotected left main coronary arteries remains an unresolved issue...
  38. ncbi Technical feasibility, safety, and clinical outcome of stenting of unprotected left main coronary artery bifurcation narrowing
    Seung Jung Park
    Department of Medicine, Asan Medical Center, University of Ulsan, Seoul, South Korea
    Am J Cardiol 90:374-8. 2002
    ....
  39. ncbi Coronary stenting after rotational atherectomy in diffuse lesions of the small coronary artery: comparison with balloon angioplasty before stenting
    Kihwan Kwon
    Ewha Women s University College of Medicine, Seoul, Korea
    Angiology 54:423-31. 2003
    ..8% vs 84.6%, p = 0.28). In conclusion, rotational atherectomy before stenting showed no additional benefit over balloon dilation with stenting in the management of diffuse lesions in small coronary vessels...
  40. ncbi Angiographically silent left main disease detected by intravascular ultrasound: a marker for future adverse cardiac events
    Mark J Ricciardi
    Division of Cardiology, Department of Medicine, Northwestern University Medical School, Northwestern Memorial Hospital, Chicago, Ill 60611, USA
    Am Heart J 146:507-12. 2003
    ..The purpose of this study was to evaluate the long-term prognosis of patients with angiographically insignificant LM coronary artery disease undergoing PCI...
  41. ncbi Successful rotational atherectomy in the setting of extensive coronary dissection: a case of failed balloon angioplasty in a nondilatable calcified lesion complicated by balloon rupture and extensive dissection
    Wesley R Pedersen
    Abbott Northwestern Hospital and Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA
    Catheter Cardiovasc Interv 59:329-32. 2003
    ..Predictors for coronary perforation when performing RA are reviewed. Our rationale and strategy to avoid the increased risk of perforation with RA in this contraindicated setting of extensive dissection is given...
  42. ncbi Comparison of directional coronary atherectomy-based intervention and stenting alone in ostial lesions of the left anterior descending artery
    Chang Min Chung
    Department of Cardiology, Chang Gung Memorial Hospital, Chiayi
    Chang Gung Med J 28:689-98. 2005
    ..Several non-balloon devices have been used to improve the outcome of dilatation of such lesions...
  43. ncbi Stenting alone versus debulking and debulking plus stent in branch ostial lesions of native coronary arteries
    Chang Min Chung
    Department of Cardiology, Chang Gung Memorial Hospital, 6 Sec West, Chai Pu Road, Putz City, Chaiyi Hsien, Taiwan
    Heart Vessels 19:213-20. 2004
    ..04). The minimal luminal diameter of the ostium had not changed after directional coronary atherectomy or at follow-up...
  44. ncbi Long-term outcomes after treatment of diffuse in-stent restenosis with rotational atherectomy followed by beta-radiation therapy with a 188Re-MAG3-filled balloon
    Seung Whan Lee
    Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, South Korea
    Int J Cardiol 99:201-5. 2005
    ..However, long-term angiographic and clinical outcomes after beta radiation therapy have not been sufficiently evaluated...
  45. ncbi Expanded applications of rotational atherectomy in contemporary coronary and peripheral interventional practice
    Ehtisham Mahmud
    Cardiac Catheterization Laboratory, Division of Cardiology, University of California, San Diego, UCSD Medical Center, 200 West Arbor Drive, San Diego, CA 92103 8784, USA
    J Invasive Cardiol 17:207-10. 2005
    ..We identify and present three novel uses for this device in percutaneous coronary and peripheral interventional procedures, which further expands the applications of rotational atherectomy...
  46. ncbi Treatment of stent-jailed side branch stenoses with rotational atherectomy
    Robert T Sperling
    Cardiovascular Associates, Sutter Pacific Heart Centers, Larkspur, California, USA
    J Invasive Cardiol 18:354-8. 2006
    ..We report our experience with RA in conjunction with BA for the treatment of ostial stenosis in jailed side branches...
  47. ncbi Comparison of angiographic and clinical outcomes between rotational atherectomy versus balloon angioplasty followed by radiation therapy with a rhenium-188-mercaptoacetyltriglycine-filled balloon in the treatment of diffuse in-stent restenosis
    Seung Whan Lee
    Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Korea
    Int J Cardiol 102:179-85. 2005
    ....
  48. ncbi A two-year, single-group experience with rotational atherectomy
    V Grigorov
    ARWYP Medical Centre, Kempton Park
    Cardiovasc J S Afr 16:148-51. 2005
    ..Complimentary PTCA and stenting improved the angiographic end result. Using this strategy, we have achieved very acceptable clinical results...
  49. ncbi Directional atherectomy before stenting versus stenting alone in percutaneous coronary interventions: a meta-analysis
    Giampaolo Niccoli
    Institute of Cardiology, Catholic University, Largo F Vito 1 00168 Rome, Italy
    Int J Cardiol 112:178-83. 2006
    ..We performed a meta-analysis of 12 randomized and non-randomized trials comparing directional coronary atherectomy (DCA) before stenting versus stenting alone...
  50. ncbi Pre-procedural ACE-activity does not predict symptomatic in-stent restenosis
    L J Wagenaar
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands
    Int J Cardiol 103:73-7. 2005
    ..Several studies indicate that ACE-activity is related to atherosclerosis. We investigated the correlation between ACE-activity, in plasma as well as in the atherosclerotic plaque, and in-stent restenosis...
  51. ncbi Stenting after directional coronary atherectomy compared with directional coronary atherectomy alone and stenting alone: a serial intravascular ultrasound study
    Akio Kawamura
    Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Circ J 68:455-61. 2004
    Directional coronary atherectomy prior to stent implantation (DCA-stent) is expected to be an effective approach to reduce restenosis...
  52. ncbi Cutting balloon angioplasty for the treatment of in-stent restenosis: a matched comparison with rotational atherectomy, additional stent implantation and balloon angioplasty
    M Adamian
    Lenox Hill Heart and Vascular Institute, New York, New York, USA
    J Am Coll Cardiol 38:672-9. 2001
    ..This approach might be implemented as a viable option in management of focal ISR and to prepare diffuse ISR for brachytherapy treatment...
  53. ncbi Coronary in-stent restenosis following beta brachytherapy: a histopathological examination
    Christian F Witzke
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Cardiovasc Pathol 13:85-90. 2004
    ..Previously unreported histopathology of directed atherectomy specimens of such restenotic lesions and a discussion of their proposed significance form the basis of this report...
  54. ncbi Immediate and one-year outcome in patients with coronary bifurcation lesions in the modern era (NHLBI dynamic registry)
    J Al Suwaidi
    Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Cardiol 87:1139-44. 2001
    ..We conclude that despite the widespread use of newer percutaneous devices, treatment of bifurcation lesions remains difficult and is associated with decreased success and increased complication rates compared with nonbifurcation lesions...
  55. ncbi First experience with hybrid percutaneous transmyocardial laser revascularization and angioplasty in patients with lesions at high risk for restenosis: Results of a phase I feasibility study
    G W Stone
    Cardiovascular Research Foundation, Lenox Hill Hospital, New York, NY 10022, USA
    Am Heart J 142:679-83. 2001
    ....
  56. ncbi Comparison of directional coronary atherectomy and stenting versus stenting alone for the treatment of de novo and restenotic coronary artery narrowing
    Goran Stankovic
    Columbus Hospital and San Raffaele Hospital, Milan, Italy
    Am J Cardiol 93:953-8. 2004
    Late lumen loss after directional coronary atherectomy (DCA) is mainly determined by arterial remodeling. We hypothesized that stent implantation after optimal lesion debulking could be an effective approach to reduce restenosis...
  57. ncbi Percutaneous transluminal coronary rotational atherectomy for localized stenosis caused by Kawasaki disease
    Etsuko Tsuda
    Department of Pediatrics, National Cardiovascular Center, Suita Shi, Osaka, Japan
    Pediatr Cardiol 27:447-53. 2006
    ..When the use of a larger burr is possible, good patency can be expected and can be maintained by close follow-up and re-PTCRA...
  58. ncbi Coronary rotational atherectomy in current practice: acute and mid-term results in high- and low-volume centers
    Paolo Rubartelli
    Division of Cardiology, Ospedale San Martino, Genoa, Italy
    Catheter Cardiovasc Interv 61:463-71. 2004
    ..Center RA volume was not associated with in-hospital or 9-month outcome. We conclude that RA, even when used sporadically in selected complex lesions, can provide good immediate and mid-term results...
  59. ncbi Myocardial protective actions of nitric oxide donors after myocardial ischemia and reperfusion
    D J Lefer
    Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    New Horiz 3:105-12. 1995
    ..strategies for the treatment of acute myocardial ischemia include coronary angioplasty, directional coronary atherectomy, and the administration of thrombolytic agents to restore blood flow to the ischemic myocardium...
  60. ncbi Histopathology of clinical coronary restenosis in drug-eluting versus bare metal stents
    Alaide Chieffo
    Department of Cardio Thoracic and Vascular Diseases, San Raffaele Scientific Institute, Milan, Italy
    Am J Cardiol 104:1660-7. 2009
    ..stents (DES; 9 PES, 10 SES, 4 TES, and 2 ZES) and 19 with bare-metal stents (BMS) underwent directional coronary atherectomy for in-stent restenosis 4 to 36 months after implantation...
  61. ncbi Cellular immunostaining of angiotensin-converting enzyme in human coronary atherosclerotic plaques
    Flavio Ribichini
    Catheterization Laboratory, Ospedale Maggiore della Carita, Universita del Piemonte Orientale, Novara, Italy
    J Am Coll Cardiol 47:1143-9. 2006
    ..The aim of this study was to determine the cellular localization of angiotensin I-converting enzyme (ACE) in the atherosclerotic plaque and its correlation with inflammation and cellular proliferation...
  62. ncbi Enhanced expression of haemoglobin scavenger receptor in accumulated macrophages of culprit lesions in acute coronary syndromes
    Kei Yunoki
    Department of Cardiology, Osaka City General Hospital, Osaka, Japan
    Eur Heart J 30:1844-52. 2009
    ..4-HNE (4-hydroxy-2-nonenal), an index of lipid peroxidation, and the Hb scavenger receptor (CD163), using coronary atherectomy specimens from 74 patients with stable angina pectoris (SAP, n = 39) or unstable angina pectoris (UAP, n = ..
  63. ncbi Increased plasminogen activator inhibitor type 1 in coronary artery atherectomy specimens from type 2 diabetic compared with nondiabetic patients: a potential factor predisposing to thrombosis and its persistence
    B E Sobel
    Department of Medicine, The University of Vermont College of Medicine, Burlington 05401, USA
    Circulation 97:2213-21. 1998
    ....
  64. ncbi Thallium-201 and I-123 beta-methyl iodophenyl-pentadecanoic acid dual isotope single photon emission computed tomography for evaluating reperfusion injury after successful reperfusion therapy
    Yasushi Akutsu
    Division of Cardiology, Department of Medicine, Showa University School of Medicine, Shinagawaku, Tokyo, Japan
    Clin Nucl Med 34:213-5. 2009
    We report a reperfusion injury after rotational coronary atherectomy (RA) in a 66-year-old man with coronary artery disease...
  65. ncbi Accuracy of in vivo coronary plaque morphology assessment: a validation study of in vivo virtual histology compared with in vitro histopathology
    Kenya Nasu
    Department of Cardiology, Toyohashi Heart Center, Toyohashi City, Aichi, Japan
    J Am Coll Cardiol 47:2405-12. 2006
    ..obtained by intravascular ultrasound (IVUS) radiofrequency (RF) data analysis, known as Virtual Histology (VH), to the in vitro histopathology of coronary atherosclerotic plaques obtained by directional coronary atherectomy.
  66. ncbi Prior cytomegalovirus infection and the risk of restenosis after percutaneous transluminal coronary balloon angioplasty
    C Manegold
    Klinik fur Gastroenterologie, Hepatologie, und Infektiologie, Institut für Medizinische Mikrobiologie und Virologie, Heinrich Hein Universität, Dusseldorf, Germany
    Circulation 99:1290-4. 1999
    ..Recent data suggest an association of restenosis after optimal coronary atherectomy with CMV serostatus, and a possible role of antiviral therapy was discussed...
  67. ncbi Creativity, ingenuity, serendipity
    David R holmes Holmes
    Mayo Clinic, Rochester, Minnesota, USA
    Can J Cardiol 21:1061-5. 2005
    ..included new devices, such as atherectomy transluminal extraction catheters, as well as with directional coronary atherectomy, rotational atherectomy and laser-based techniques...
  68. ncbi Tissue factor in the pathogenesis of atherosclerosis
    M B Taubman
    Mount Sinai School of Medicine, New York, NY, USA
    Thromb Haemost 78:200-4. 1997
    ..Interventions, such as balloon angioplasty, coronary atherectomy, or stent placement may expose intimal TF, leading to fibrin deposition...
  69. ncbi Neopterin and atherosclerotic plaque instability in coronary and carotid arteries
    Kenichi Sugioka
    Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 17:1115-21. 2010
    ..Furthermore, in an immunohistochemical study performed using coronary atherectomy specimens, a significantly higher prevalence of neopterin-positive macrophages was found in culprit lesions ..
  70. ncbi Replication in restenotic atherectomy tissue
    E R O'Brien
    Vascular Biology Laboratory, Department of Medicine Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ont, K1Y 4W7, Ottawa, Canada
    Atherosclerosis 152:117-26. 2000
    Previously, we demonstrated that replication in restenotic coronary atherectomy specimens was an infrequent and modest event...
  71. ncbi Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system
    W S Post
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cardiovasc Res 43:985-91. 1999
    ..In this study, we sought to determine whether such age-related methylation occurs in the cardiovascular system, and whether it is associated with atherosclerotic disease...
  72. ncbi Clinical significance of echo signal attenuation on intravascular ultrasound in patients with coronary artery disease
    Shigeki Kimura
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ Cardiovasc Interv 2:444-54. 2009
    ..We investigated the impact of EA on coronary perfusion and evaluated the pathological features of plaque with EA...
  73. ncbi CagA antigen of Helicobacter pylori and coronary instability: insight from a clinico-pathological study and a meta-analysis of 4241 cases
    Francesco Franceschi
    Emergency Department, Catholic University of Sacred Heart, Rome, Italy
    Atherosclerosis 202:535-42. 2009
    ..pylori). The role of CagA antigen in coronary instability is unknown. We performed a clinico-pathological study and a meta-analysis in the attempt to shed new light on this complex issue...
  74. ncbi Secretory type II phospholipase A2 in culprit coronary lesions is associated with myocardial infarction
    R Nijmeijer
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Eur J Clin Invest 38:205-10. 2008
    ..We have studied the presence of sPLA(2)-II in culprit lesions in the coronary arteries of patients with acute myocardial infarction (AMI) or angina pectoris...
  75. ncbi Pre-drug-eluting stent debulking of bifurcated coronary lesions
    Etsuo Tsuchikane
    Department of Cardiology, Toyohashi Heart Center, Aichi, Japan
    J Am Coll Cardiol 50:1941-5. 2007
    The purpose of this study was to evaluate the efficacy of plaque debulking by directional coronary atherectomy (DCA) before drug-eluting stent (DES) implantation for bifurcated coronary lesions.
  76. ncbi Different quantitative apoptotic traits in coronary atherosclerotic plaques from patients with stable angina pectoris and acute coronary syndromes
    Marco L Rossi
    Division of Cardiology, Istituto Clinico Humanitas, Milan, Italy
    Circulation 110:1767-73. 2004
    ..We tested the hypothesis that apoptosis is quantitatively increased in unstable atherosclerotic plaques...
  77. ncbi Very late thrombosis of sirolimus-eluting stent due to late malapposition: serial observations with optical coherence tomography
    Takahiro Sawada
    Kobe University Graduate School of Medicine, Division of Cardiovascular Medicine, Department of Internal Medicine, Japan
    J Cardiol 52:290-5. 2008
    A 54 years old man underwent directional coronary atherectomy in segment 7 with a partial deep-cut injury. A sirolimus-eluting stent (SES) was implanted at the restenosed post-atherectomy lesion...
  78. ncbi Unprotected left main coronary artery bifurcation stenosis: impact of plaque debulking prior to single sirolimus-eluting stent implantation
    Nobuyoshi Tanaka
    Department of Cardiology, Toyohashi Heart Center, 21 1 Gobudori, Oyama cho, Toyohashi, 441 8530, Japan
    J Invasive Cardiol 20:505-10. 2008
    The impact of plaque debulking with directional coronary atherectomy (DCA) prior to single sirolimus-eluting stent (SES) implantation in an unprotected left main coronary artery (LMCA) involving bifurcation stenosis has not been fully ..
  79. ncbi Phenotype commitment in vascular smooth muscle cells derived from coronary atherosclerotic plaques: differential gene expression of endothelial nitric oxide synthase
    M L Rossi
    Istituto Clinico Humanitas, Unità Operativa di Emodinamica e Cardiologia Interventistica, Via Manzoni 56, 20089 Rozzano MI, Italy
    Eur J Histochem 49:39-46. 2005
    ..TaqMan PCRs) to study gene expression in coronary plaques collected by means of therapeutic directional coronary atherectomy from 15 patients with stable angina (SA) and 15 with acute coronary syndromes (ACS) without ST elevation...
  80. ncbi Comparison of proliferative activity in coronary plaques from patients with coronary ischemia. Histopathological and immunohistochemical analysis
    H Ueda
    Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Hiroshima J Med Sci 46:31-42. 1997
    ..The proliferative activity in tissues obtained by using directional coronary atherectomy (DCA) from 87 coronary lesions was assessed by immunohistochemical staining for the proliferating cell ..
  81. ncbi Network analysis of human in-stent restenosis
    Euan A Ashley
    Division of Cardiovascular Medicine, Falk CVRC, Stanford University, Stanford, Calif 94305, USA
    Circulation 114:2644-54. 2006
    ..We analyzed human coronary atheroma in de novo and restenotic disease to identify targets of therapy that might avoid these limitations...
  82. ncbi C-reactive protein and coronary composition in patients with percutaneous revascularization
    A Pucci
    Regina Margherita Hospital, ASO OIRM S Anna, Turin, Italy
    Eur J Clin Invest 38:281-9. 2008
    ..Whether serum CRP levels are associated with in vivo atherothrombotic features is unclear. We thus analysed samples from coronary atherectomy specimens obtained during percutaneous coronary intervention.
  83. ncbi [Pathomorphology of coronary atherosclerosis]
    C Ihling
    Institut fur Pathologie, Universitat Freiburg
    Herz 23:69-77. 1998
    ..We examined immunohistochemically the presence of ET-1 in coronary plaque tissue obtained by directional coronary atherectomy. ET-1 immunoreactivity preferentially localized in plaque components indicative of a chronic inflammatory ..
  84. ncbi Increased expression of monocyte chemoattractant protein-1 in atherectomy specimens from patients with restenosis after percutaneous transluminal coronary angioplasty
    Seiji Hokimoto
    Division of Cardiology, Kumamoto Central Hospital, Kumamoto City, Japan
    Circ J 66:114-6. 2002
    ..In this study the MCP-1 expression of coronary atherectomy specimens was investigated by immunohistochemistry...
  85. pmc The whole nine yards: multiple cardiac surgical and percutaneous interventions in a patient during 30 years of care
    Khaled Albouaini
    The Cardiothoracic Centre, Liverpool, Merseyside, United Kingdom
    Can J Cardiol 24:e77-9. 2008
    ..grafting, percutaneous transluminal coronary angioplasty and intragraft thrombolytic therapy, directional coronary atherectomy, cutting balloon angioplasty, intracoronary stenting with bare-metal and drug-eluting stents, treatment for ..
  86. ncbi Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques
    Mariana S Parahuleva
    Internal Medicine I Cardiology and Angiology, Justus Liebig University, Giessen, Germany
    Atherosclerosis 196:164-71. 2008
    ..In order to define the role of FSAP in vascular pathophysiology we have investigated the expression of FSAP protein and mRNA in human vascular cells and coronary atherosclerotic plaques with defined clinical features...
  87. ncbi Identification of differentially expressed genes in coronary atherosclerotic plaques from patients with stable or unstable angina by cDNA array analysis
    A M Randi
    Experimental Medicine, GlaxoSmithKline, Stevenage, UK
    J Thromb Haemost 1:829-35. 2003
    ..Total RNA was extracted from eight plaques collected by therapeutic directional coronary atherectomy. cDNA probes, generated by amplification, were hybridized to nylon arrays containing 482 genes...
  88. ncbi Presence of Chlamydia pneumoniae in patients with and without atherosclerosis
    E Podsiadły
    National Institute of Hygiene, Laboratory of Rickettsiae, Chlamydiae and Enzotic Spirochetes, Chocimska 24, 00 791, Warsaw, Poland
    Eur J Clin Microbiol Infect Dis 24:507-13. 2005
    ..C. pneumoniae DNA was found most often in directional coronary atherectomy tissue specimens (11/41, 26.8%), but it was also found in the leukocytes of 14...
  89. ncbi Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina
    S Miyamoto
    Division of Cardiology, Kitano Hospital, Tadukekofukai Medical Research Institute, Osaka, Japan
    Heart 94:1002-7. 2008
    ..The S100A8/A9 complex is expressed in a subset of activated neutrophils and macrophages in acute inflammatory lesions associated with various diseases...
  90. ncbi Expression of matrix metalloproteinase 9 and its regulators in the unstable coronary atherosclerotic plaque
    Fei Chen
    Crafoord Laboratory, South Hospital, Stockholm, Sweden
    Int J Mol Med 15:57-65. 2005
    ..plaques from patients with stable (n=22) and unstable (n=39) angina were obtained by directional coronary atherectomy and analysed by semiquantitative RT-PCR and immunohisto-chemistry. Plasma was collected for ELISA analysis...
  91. ncbi Ultrasound attenuated coronary plaque as a risk factor for slow flow or no-reflow during percutaneous coronary intervention: a case report
    Shinichi Furuichi
    Department of Cardiology, Osaka City General Hospital, Miyakojima hondori, Miyakojima ku, Osaka
    J Cardiol 49:193-7. 2007
    ..Since the lesion was highly eccentric in the large left anterior descending artery, directional coronary atherectomy (DCA) and subsequent stent implantation were planned. Serious no-reflow occurred after DCA...
  92. ncbi Intravascular two-dimensional tissue strain imaging
    Yoshifumi Saijo
    Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Seiryomachi, Aoba ku, Sendai, Japan
    Ultrasonics 44:e147-51. 2006
    ..7 and more correlation. IVUS studies were performed in directional coronary atherectomy (DCA) procedures...
  93. ncbi Serial extracellular matrix changes in neointimal lesions of human coronary artery after percutaneous transluminal coronary angioplasty: clinical significance of early tenascin-C expression
    K Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, Tsu, Japan
    Virchows Arch 439:185-90. 2001
    ..tissue, we morphologically and semiquantitatively analyzed specimens obtained by means of directional coronary atherectomy at various stages after PTCA with anti-fibronectin, tenascin-C, collagens I and III, and PG-M/versican ..
  94. ncbi 5 French guide catheters for percutaneous coronary intervention: a feasibility study in 100 consecutive patients
    J A Ormiston
    Auckland Heart Group, Auckland, New Zealand
    Catheter Cardiovasc Interv 52:45-8. 2001
    ..Reasons for not selecting a 5 Fr guide were planned kissing balloons (eight), directional coronary atherectomy (one), and no suitable 5 Fr guide in stock (seven)...
  95. ncbi Fibroblast growth factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells
    Takehiro Nakahara
    Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 394:243-8. 2010
    ..Immunohistochemistry of human coronary atherectomy specimens and calcified aortic tissues showed that expression of FGF receptor-1 and Runx2 was colocalized...
  96. ncbi Iatrogenic coronary artery stenosis at the ostium of left anterior descending artery after aortic valve replacement: a case report with imaging and histological findings
    Yoshimori An
    Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan
    J Invasive Cardiol 22:E206-8. 2010
    ..Intravascular ultrasound provided helpful information to choose and perform directional coronary atherectomy (DCA) as the strategy of percutaneous coronary intervention...
  97. ncbi Fractional flow reserve in a patient with intermediate coronary stenosis and hypertrophic cardiomyopathy
    Masaki Tsukamoto
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Interv Cardiol 15:23-8. 2002
    ..1 and 0.59), suggesting that the stenosis was functionally significant. Directional coronary atherectomy greatly improved the FFRmyo (0...
  98. ncbi Radial versus femoral approach for high-speed rotational atherectomy
    Jonathan Watt
    Department of Cardiology, Western Infirmary, Glasgow G11 6NT, Scotland
    Catheter Cardiovasc Interv 74:550-4. 2009
    ..The aim of this study was to compare in-hospital outcomes for patients undergoing high-speed rotational atherectomy (HSRA) via the radial and femoral route...
  99. ncbi Coronary perforations: old screenplay, new actors!
    Antonio Colombo
    Centro Cuore Columbus, Milan, Italy
    J Invasive Cardiol 16:302-3. 2004
  100. ncbi New approaches to ostial and bifurcation lesions
    Angela Hoye
    Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    J Interv Cardiol 17:397-403. 2004
    ..This paper reviews the available technologies and their relative merits...
  101. ncbi Revascularization of a thrombosed, previously stented aorto-renal graft using combined directional atherectomy and AngioJet thrombectomy
    A Seth
    Department of Cardiology, Escorts Heart Institute and Research Center, New Delhi, India
    Catheter Cardiovasc Interv 46:85-8. 1999
    ..Combined debulking by AngioJet thrombectomy and Simpsons directional atherectomy was performed within the stent following reocclusion of the graft 9 months later...

Research Grants6

  1. Safer Antithrombotic Therapy for Elderly ACS Patients
    Eric Peterson; Fiscal Year: 2006
    ..Finally, we will use established relations with professional societies and the VHA to widely disseminate our study's major findings. ..
  2. CHOLESTEROL & PLAQUE RUPTURE--WOMEN AND PLAQUE EROSION
    Renu Virmani; Fiscal Year: 2001
    ..In addition, analysis of plaque morphology in the animal model proposed in Project 4 will be carried out in project 1. ..
  3. Plaque Progression, Apoptosis and Inflammation
    Renu Virmani; Fiscal Year: 2005
    ..abstract_text> ..
  4. MESA Family Study
    Wendy Post; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  5. An Automated System to Monitor Medical Device Safety
    Frederic Resnic; Fiscal Year: 2009
    ..This approach can be readily extended to monitor the safety of technologies outside of interventional cardiology as outcomes data repositories become available. ..
  6. Nanoscale approaches to allelic silencing in myocardial disease states
    Euan Ashley; Fiscal Year: 2009
    ..This familial condition where the heart grows too thick is the most common cause of sudden death in young people and athletes. ..