plasma exchange

Summary

Summary: Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.

Top Publications

  1. ncbi Clinical practice. Thrombotic thrombocytopenic purpura
    James N George
    Hematology Oncology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    N Engl J Med 354:1927-35. 2006
  2. ncbi Thrombotic microangiopathy: current knowledge and outcomes with plasma exchange
    William F Clark
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Semin Dial 25:214-9. 2012
  3. ncbi Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange
    Mark Keegan
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet 366:579-82. 2005
  4. ncbi Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic-uraemic syndrome: an analysis of the German STEC-HUS registry
    Jan T Kielstein
    Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 27:3807-15. 2012
  5. ncbi Eculizumab in the treatment of atypical hemolytic uremic syndrome in infants
    Gema Ariceta
    Pediatric Nephrology, Hospital Universitario Cruces, Barakaldo Bilbao, Spain
    Am J Kidney Dis 59:707-10. 2012
  6. ncbi Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis
    Jui Hao Chen
    Department of Gastroenterology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wenchang Road, Shih Lin District, Taipei, Taiwan, China
    World J Gastroenterol 10:2272-4. 2004
  7. ncbi Management of an acute outbreak of diarrhoea-associated haemolytic uraemic syndrome with early plasma exchange in adults from southern Denmark: an observational study
    Edin Colic
    Department of Nephrology, Odense University Hospital, Odense, Denmark
    Lancet 378:1089-93. 2011
  8. ncbi Immunoglobulin treatment versus plasma exchange in patients with chronic moderate to severe myasthenia gravis
    J Rønager
    Department of Neurology, Neuroscience Center, National University Hospital, Copenhagen, Denmark
    Artif Organs 25:967-73. 2001
  9. ncbi Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom
    C Mark Taylor
    Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, UK
    Br J Haematol 148:37-47. 2010
  10. pmc Beneficial plasma exchange response in central nervous system inflammatory demyelination
    Setty M Magaña
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arch Neurol 68:870-8. 2011

Detail Information

Publications285 found, 100 shown here

  1. ncbi Clinical practice. Thrombotic thrombocytopenic purpura
    James N George
    Hematology Oncology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    N Engl J Med 354:1927-35. 2006
  2. ncbi Thrombotic microangiopathy: current knowledge and outcomes with plasma exchange
    William F Clark
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Semin Dial 25:214-9. 2012
    ..The advent of plasma therapy in the treatment of thrombotic microangiopathy has led to a clearer understanding of the role of ADAMTS13, both short- and long-term outcomes and the need for future surveillance and intervention...
  3. ncbi Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange
    Mark Keegan
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet 366:579-82. 2005
    ..Therapeutic plasma exchange (TPE) has been successfully used to treat fulminant demyelinating attacks unresponsive to steroids...
  4. ncbi Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic-uraemic syndrome: an analysis of the German STEC-HUS registry
    Jan T Kielstein
    Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 27:3807-15. 2012
    ..May 22nd marks the beginning of a Shiga-toxin-producing Escherichia coli (STEC) O104:H4 outbreak in Northern Germany. By its end on 27 July, it had claimed 53 deaths among 2987 STEC and 855 confirmed haemolytic-uraemic syndrome (HUS) cases...
  5. ncbi Eculizumab in the treatment of atypical hemolytic uremic syndrome in infants
    Gema Ariceta
    Pediatric Nephrology, Hospital Universitario Cruces, Barakaldo Bilbao, Spain
    Am J Kidney Dis 59:707-10. 2012
    ..73 m(2) [0.25 mL/s/1.73 m(2)]). Repeated high-volume plasma infusions were ineffective. Plasma exchange was attempted, but not tolerated...
  6. ncbi Therapeutic plasma exchange in patients with hyperlipidemic pancreatitis
    Jui Hao Chen
    Department of Gastroenterology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wenchang Road, Shih Lin District, Taipei, Taiwan, China
    World J Gastroenterol 10:2272-4. 2004
    To clarify the effectiveness of plasma exchange by comparing the mortality and morbidity before and after the intervention of plasma exchange.
  7. ncbi Management of an acute outbreak of diarrhoea-associated haemolytic uraemic syndrome with early plasma exchange in adults from southern Denmark: an observational study
    Edin Colic
    Department of Nephrology, Odense University Hospital, Odense, Denmark
    Lancet 378:1089-93. 2011
    ..We aimed to assess the success of management of this disorder with plasma exchange therapy.
  8. ncbi Immunoglobulin treatment versus plasma exchange in patients with chronic moderate to severe myasthenia gravis
    J Rønager
    Department of Neurology, Neuroscience Center, National University Hospital, Copenhagen, Denmark
    Artif Organs 25:967-73. 2001
    ..of this study was to compare the efficacy of high-dose intravenous immunoglobulin (IVIG) treatment with plasma exchange in patients suffering from moderate to severe myasthenia gravis (MG) in a stable phase...
  9. ncbi Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom
    C Mark Taylor
    Institute of Human Genetics, Newcastle University, Central Parkway, Newcastle upon Tyne, UK
    Br J Haematol 148:37-47. 2010
    ..We particularly address the role of renal transplantation alone and combined liver-kidney transplantation...
  10. pmc Beneficial plasma exchange response in central nervous system inflammatory demyelination
    Setty M Magaña
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arch Neurol 68:870-8. 2011
    b>Plasma exchange (PLEX) is a beneficial rescue therapy for acute, steroid-refractory central nervous system inflammatory demyelinating disease (CNS-IDD)...
  11. ncbi Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura
    X Long Zheng
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, ARC 316, Philadelphia, PA 19104, USA
    Blood 103:4043-9. 2004
    Therapeutic plasma exchange is an effective empiric treatment for thrombotic thrombocytopenic purpura (TTP), but how therapy affects the level of a disintegrin and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) or ..
  12. ncbi Immunotherapy for Guillain-Barré syndrome: a systematic review
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London, Guy s Campus, London, UK
    Brain 130:2245-57. 2007
    ..In four trials with altogether 585 severely affected adult participants, those treated with plasma exchange (PE) improved significantly more on this scale 4 weeks after randomization than those who did not, weighted ..
  13. ncbi Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression
    J B Levy
    Renal Section, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road, London W12 ONN, United Kingdom
    Ann Intern Med 134:1033-42. 2001
    ..PATIENTS: 71 treated patients with anti-GBM antibody disease. INTERVENTION: All patients received plasma exchange, prednisolone, and cyclophosphamide...
  14. ncbi Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica
    S Watanabe
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Mult Scler 13:128-32. 2007
    ..and three with myelitis) who were unresponsive to high-dose intravenous methylprednisolone (HIMP), with plasma exchange (PE) (three to five exchanges, 2-3 L each)...
  15. ncbi ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients
    Sara K Vesely
    Hematology Oncology Section, The University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Blood 102:60-8. 2003
    ..syndrome (TTP-HUS) is difficult because of lack of specific diagnostic criteria, high mortality without plasma exchange treatment, and risks of plasma exchange...
  16. ncbi Plasma exchange for induction and cyclosporine A for maintenance of remission in Wegener's granulomatosis--a clinical randomized controlled trial
    Wladimir M Szpirt
    Department of Nephrology, Rigshospitalet University Hospital, Copenhagen, Denmark
    Nephrol Dial Transplant 26:206-13. 2011
    The use of plasma exchange (PE) for induction treatment of anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis (AAV), including Wegener's granulomatosis (WG), is still controversial...
  17. ncbi Alternative complement pathway assessment in patients with atypical HUS
    Lubka T Roumenina
    Cordeliers Research Center, INSERM UMRS 872, 75006 Paris, France
    J Immunol Methods 365:8-26. 2011
    ..Finally, we will discuss how the therapy of aHUS patients can be modified according to the functional consequences of each particular genetic defect...
  18. ncbi Removal of elevated circulating angiopoietin-2 by plasma exchange--a pilot study in critically ill patients with thrombotic microangiopathy and anti-glomerular basement membrane disease
    Svjetlana Lovric
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Thromb Haemost 104:1038-43. 2010
    ..We hypothesised that plasma exchange (PE) is efficient for lowering excess Ang-2 levels in critically ill patients with thrombocytic ..
  19. pmc Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure
    Trung C Nguyen
    Section of Critical Care, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Crit Care Med 36:2878-87. 2008
    ..formerly known as von Willebrand factor (VWF) cleaving protease, is decreased in adults with VWF-mediated thrombotic microangiopathy, and intensive plasma exchange (PEx) both replenishes ADAMTS-13 and improves outcome in these patients.
  20. ncbi Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome
    Stefanie Strobel
    Junior Research Group Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    Kidney Int 80:397-404. 2011
    ..Analysis of the IgG fractions in CFHR1-deficient patients found that CFHR1-IgG complexes were formed during plasma exchange treatment, indicating that autoantibodies recognize CFHR1 in vivo...
  21. ncbi Prediction value of model for end-stage liver disease scoring system on prognosis in patients with acute-on-chronic hepatitis B liver failure after plasma exchange and lamivudine treatment
    Jian Wu Yu
    Department of Infectious Diseases, Second Affiliated Hospital, Harbin Medical University, Harbin, China
    J Gastroenterol Hepatol 23:1242-9. 2008
    ..disease (MELD) scoring system to predict the 3-month prognosis of patients with acute-on-chronic liver failure (ACLF) after plasma exchange (PE) and lamivudine treatment, and studied the predictive factors on the prognosis of patients.
  22. ncbi Eculizumab in atypical hemolytic uremic syndrome: long-term clinical course and histological findings
    Sibylle Tschumi
    Division of Paediatric Nephrology, Children s Hospital, University of Bern, 3010 Berne, Switzerland
    Pediatr Nephrol 26:2085-8. 2011
    ..The prognosis for patients with aHUS is poor, and plasma exchange represents the first-line therapy...
  23. ncbi Disseminated intravascular coagulation due to cytomegalovirus infection in an immunocompetent adult treated with plasma exchange
    Timothy B Niewold
    Department of Rheumatology, Hospital for Special Surgery, New York, New York 10021, USA
    Am J Hematol 81:454-7. 2006
    ..coagulation (DIC) due to acute cytomegalovirus (CMV) infection and was successfully treated with plasma exchange. Extensive investigations revealed no other cause for her DIC, and she did not have any recurrence after more ..
  24. ncbi Potential benefits of plasma exchange by apheresis on the treatment of severe Icteric Leptospirosis: case report and literature review
    César Cerdas-Quesada
    Universidad Nacional de Rosario e Instituto Universitario Italiano de Rosario, Rosario, Argentina
    Transfus Apher Sci 45:191-4. 2011
    ..This case report show how plasma exchange prevents the multiorganic failure.
  25. ncbi Treatment of optic neuritis by plasma exchange (add-on) in neuromyelitis optica
    Harold Merle
    Service d Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, Hopital Pierre Zobda Quitman, Martinique, France
    Arch Ophthalmol 130:858-62. 2012
    To assess the contribution of plasma exchange (PE) in association (add-on) with pulsed intravenous corticosteroids in acute optic neuritis of neuromyelitis optica (NMO) and limited forms of NMO.
  26. ncbi Plasma exchange improves graft survival in patients with recurrent focal glomerulosclerosis after renal transplant
    Jereon K J Deegens
    Department of Medicine, University Medical Center of Nijmegen, The Netherlands
    Transpl Int 17:151-7. 2004
    ..b>Plasma exchange (PE) can reduce proteinuria and even induce complete remission of proteinuria...
  27. ncbi Therapeutic plasma exchange in patients with severe hypertriglyceridemia: a multicenter study
    Claudia Stefanutti
    University of Rome La Sapienza, Umberto I Hospital, Department of Clinical and Medical Therapy, Plasmapheresis Unit, Rome, Italy
    Artif Organs 33:1096-102. 2009
    ..conventional medical therapy (fat-free diet plus pharmaceutical interventions) were referred for therapeutic plasma exchange (TPE) in a multicenter frame case series study...
  28. ncbi The role of antibodies in multiple sclerosis
    Martin S Weber
    Department of Neurology, Technische Universität Müchen, Munich, Germany
    Biochim Biophys Acta 1812:239-45. 2011
    ..of a pathogenic role for antibodies in MS is nevertheless empirically supported by the clinical benefit of plasma exchange in patients with histologic signs of antibody deposition within the CNS...
  29. ncbi Plasma exchange in severe spinal attacks associated with neuromyelitis optica spectrum disorder
    M Bonnan
    Service de Neurologie, Hôpital Zobda Quitman, 97261 Fort de France, Martinique, French West Indies
    Mult Scler 15:487-92. 2009
    b>Plasma exchange (PE) is increasingly undertaken in diseases involving humoral factors and is proven to be beneficial in acute demyelinating diseases...
  30. ncbi Conventional apheresis therapies: a review
    David M Ward
    Division of Nephrology, University of California San Diego, San Diego, California, USA
    J Clin Apher 26:230-8. 2011
    ..Therapeutic white cell reduction (leukapheresis), platelet reduction (thrombocytapheresis) and red cell exchange (erythrocytapheresis) require centrifugal apheresis systems...
  31. ncbi Plasma exchange for refractory Kawasaki disease
    Tomoyuki Imagawa
    Department of Paediatrics, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, 236 0004 Yokohama, Japan
    Eur J Pediatr 163:263-4. 2004
  32. ncbi Maintenance of kidney function following treatment with eculizumab and discontinuation of plasma exchange after a third kidney transplant for atypical hemolytic uremic syndrome associated with a CFH mutation
    Jean Claude Davin
    Paediatric Nephrology Department, Emma Children s Hospital Academic Medical Centre of Amsterdam, Amsterdam Zuid Oost, The Netherlands
    Am J Kidney Dis 55:708-11. 2010
    ..Long-term prophylactic plasma exchange and combined liver-kidney transplant have prevented graft loss caused by recurrence...
  33. ncbi Adjuvant therapeutic plasma exchange in liver failure: assessments of clinical and laboratory parameters
    Mehmet Bektas
    Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
    J Clin Gastroenterol 42:517-21. 2008
    Therapeutic plasma exchange (TPE) seems to be an effective approach for clearing toxins, immune-mediated antigens, and other particles from the circulation...
  34. ncbi The use of theraputic plasma exchange (TPE) in the setting of refractory burn shock
    Lucas P Neff
    Wake Forest University Baptist Medical Center, Department of General Surgery, Winston Salem, NC 27157, USA
    Burns 36:372-8. 2010
    This study examines the physiologic effects of theraputic plasma exchange (TPE) in the setting of refractory burn shock and attempts to identify variables that correlate with the eventual need for TPE.
  35. ncbi Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a systematic review
    Xavier Bosch
    Department of Internal Medicine, Hospital Clinic, Barcelona, Spain
    JAMA 298:655-69. 2007
    ..Long-term treatment and disease-related morbidity are major threats. The last decade has seen a collaborative international effort to determine effective treatment...
  36. ncbi [Plasma exchange therapy for steroid-unresponsive multiple sclerosis relapses: clinical experience with 16 patients]
    S Schilling
    Institut für Multiple Sklerose Forschung, Bereich Humanmedizin der Universität Göttingen und Gemeinnützige Hertie Stiftung
    Nervenarzt 77:430-8. 2006
    ..MS) relapses which do not respond sufficiently to corticosteroids can undergo escalating immunotherapy with plasma exchange. We review the course of 14 apheresis cycles in 13 adult patients and three pediatric cases from our center ..
  37. pmc Plasma therapy in atypical haemolytic uremic syndrome: lessons from a family with a factor H mutation
    Jean Claude Davin
    Pediatric Nephrology, Emma Children s Hospital Academic Medical Centre, 9 Meibergdreef, 1105, Amsterdam Z O, The Netherlands
    Pediatr Nephrol 23:1517-21. 2008
    Whilst randomised control trials are undoubtedly the best way to demonstrate whether plasma exchange or infusion alone is the best first-line treatment for patients with atypical haemolytic uremic syndrome (aHUS), individual case reports ..
  38. ncbi Plasma exchange in neuroimmunological disorders: Part 1: Rationale and treatment of inflammatory central nervous system disorders
    Helmar C Lehmann
    Department of Neurology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Arch Neurol 63:930-5. 2006
    b>Plasma exchange is a well-established therapeutic procedure commonly used in many neurological disorders of autoimmune etiology...
  39. ncbi Plasma exchange for severe optic neuritis: treatment of 10 patients
    K Ruprecht
    Clinical Research Unit for Multiple Sclerosis and Neuroimmunology, Julius Maximilians University, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Neurology 63:1081-3. 2004
    The authors reviewed a series of 10 consecutive patients treated with plasma exchange (PE) for acute, severe optic neuritis (ON) largely unresponsive to previous high-dose IV glucocorticosteroids...
  40. ncbi Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines
    D S Goodin
    Neurology 58:169-78. 2002
  41. ncbi Plasma exchange for severe attacks of inflammatory demyelinating diseases of the central nervous system
    B G Weinshenker
    Department of Neurology, Mayo Clinic Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Apher 16:39-42. 2001
    b>Plasma exchange has not been widely accepted as a treatment for multiple sclerosis...
  42. ncbi Chances of renal recovery for dialysis-dependent ANCA-associated glomerulonephritis
    Robert A F de Lind van Wijngaarden
    Department of Pathology, Leiden University Medical Center, Albinusdreef 2, Leiden, Netherlands
    J Am Soc Nephrol 18:2189-97. 2007
    ..diagnosis received uniform, standard immunosuppressive therapy plus either intravenous methylprednisolone or plasma exchange. Eleven clinical and histologic variables were assessed...
  43. ncbi Plasma exchange with immunosuppression in pulmonary alveolar haemorrhage due to leptospirosis
    Samir V Trivedi
    Department of Medicine, Government Medical College, Surat, India
    Indian J Med Res 131:429-33. 2010
    ..As other immune pulmonary haemorrhages due to non leptospiral causes are treated with plasma exchange and cyclophosphamide we evaluated their efficacy in patient with leptospiral pulmonary haemorrhage.
  44. ncbi Plasma exchange as rescue therapy in multiple organ failure including acute renal failure
    Bernd G Stegmayr
    Division of Nephrology, Department of Internal Medicine, Medicinkliniken, University Hospital, SE 901 85 Umea, Sweden
    Crit Care Med 31:1730-6. 2003
    To describe the outcome of using a rescue therapy including plasma exchange given to patients with a progressive acute disseminated intravascular coagulation and multiple organ dysfunction syndrome.
  45. ncbi The rescue effect of plasma exchange for neuromyelitis optica
    Kai Chen Wang
    Section of Neurology, Department of Internal Medicine, Chin Shin Rehabilitation Medical Center, Taipei, Taiwan
    J Clin Neurosci 18:43-6. 2011
    ..There are only a few reports of plasma exchange (PE) as an effective rescue treatment when high-dose steroid therapy fails in exacerbations of NMO...
  46. pmc Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function
    B O Khatri
    Regional Multiple Sclerosis Center and Center for Neurological Disorders, Aurora St Luke s Medical Center, Milwaukee, WI, USA
    Neurology 72:402-9. 2009
    ..Treatment of PML requires immune reconstitution. Plasma exchange (PLEX) may accelerate mAb clearance, restoring the function of inhibited proteins and increasing the number ..
  47. ncbi Plasma exchange or immunoadsorption in patients with rapidly progressive crescentic glomerulonephritis. A Swedish multi-center study
    B G Stegmayr
    Department of Nephrology, University Hospital of Umea, Sweden
    Int J Artif Organs 22:81-7. 1999
    A therapeutic removal of antibodies may be achieved by immunoadsorption (IA) or by plasma exchange (PE)...
  48. ncbi Plasma exchange as a therapeutic option in patients with neurologic symptoms due to antibodies to voltage-gated potassium channels: a report of five cases and review of the literature
    Elizabeth A Jaben
    Department of Laboratory Medicine and Pathology, Division of Clinical Pathology, Mayo Clinic Hospital, Phoenix, AZ, USA
    J Clin Apher 27:267-73. 2012
    ..A record review identified five patients with laboratory evidence of antibodies to VGKC who underwent plasma exchange (PE) as part of their immunosuppressive therapy for neurologic disease...
  49. ncbi Plasma exchange in a patient with primary antiphospholipid syndrome undergoing kidney transplantation
    Amelia Ruffatti
    Transpl Int 20:475-7. 2007
  50. ncbi Therapeutic plasma exchange for the treatment of anti-NMDA receptor encephalitis
    Huy P Pham
    Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Apher 26:320-5. 2011
    ..Four female patients had ovarian teratomas, which were removed as part of their treatment. Therapeutic plasma exchange (TPE) was used as one of the treatment modalities in addition to immunosuppressive therapy, including ..
  51. ncbi Successful treatment with plasma exchange in adult-onset Still's disease with hyper-IL-18-naemia and hyperallergic state
    Tomoki Ito
    First Department of Internal Medicine, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    Mod Rheumatol 18:407-10. 2008
    ..His serum levels of interleukin-10 and 18 showed a similar trend to his disease activity. Drug lymphocyte stimulation tests were positive for three drugs in the patient. Hypercytokinaemia was controlled by plasma exchange therapy.
  52. ncbi An evaluation of cyclosporin and corticosteroids individually as adjuncts to plasma exchange in the treatment of thrombotic thrombocytopenic purpura
    Spero R Cataland
    Division of Hematology Oncology, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Br J Haematol 136:146-9. 2007
    ..cohort studies that evaluated the clinical effects of corticosteroids or cyclosporin as an adjunct to plasma exchange (PE) for the treatment of an acute episode of thrombotic thrombocytopenic purpura (TTP)...
  53. ncbi Anti-CD20 antibody in thrombotic thrombocytopenic purpura refractory to plasma exchange
    K V Chow
    Department of Nephrology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Intern Med J 37:329-32. 2007
    ..While plasma exchange has reduced mortality from more than 90% to between 10 and 30%, a proportion of cases fail to respond...
  54. ncbi Rituximab as an adjunct to plasma exchange in TTP: a report of 12 cases and review of literature
    Sushama Jasti
    Division of Hematology Oncology, SUNY Upstate Medical University, Syracuse, New York, USA
    J Clin Apher 23:151-6. 2008
    ..We report a retrospective review of 12 patients treated with rituximab for TTP refractory to plasma exchange. Eleven patients were treated during initial presentation, and one patient was treated for recurrent relapse...
  55. ncbi Successful hemoperfusion and plasma exchange in acute hepatic failure due to snake bile intoxication
    Shyh Ming Hong
    Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan, R O C
    Chang Gung Med J 31:207-11. 2008
    ..In summary, we suggest that blood purification procedures should be done as soon as possible for snake gallbladder-related fulminant hepatitis due to its high mortality rate...
  56. pmc Plasma exchange for renal vasculitis and idiopathic rapidly progressive glomerulonephritis: a meta-analysis
    Michael Walsh
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Am J Kidney Dis 57:566-74. 2011
    b>Plasma exchange may be effective adjunctive treatment for renal vasculitis. We performed a systematic review and meta-analysis of randomized controlled trials of plasma exchange for renal vasculitis.
  57. ncbi Human immunodeficiency virus associated thrombotic thrombocytopenic purpura--favourable outcome with plasma exchange and prompt initiation of highly active antiretroviral therapy
    Daniel Hart
    Department of Haematology, St Bartholomew s and the London Hospital, London, UK
    Br J Haematol 153:515-9. 2011
    ..Prompt initiation/re-initiation of HAART in parallel with plasma exchange (PEX)±steroid led to prompt remission. Adjunct immunomodulatory agents (e.g...
  58. ncbi A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura
    Marie Scully
    Department of Haematology, University College London Hospital, London, United Kingdom
    Blood 118:1746-53. 2011
    ..Rituximab should be considered in conjunction with standard therapy on acute presentation of TTP. This study was registered at www.clinicaltrials.gov as NCT009-3713...
  59. ncbi A case report on the role of plasma exchange in the management of a massive amlodipine besylate intoxication
    Christian Ezidiegwu
    Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Ther Apher Dial 12:180-4. 2008
    Therapeutic plasma exchange is a procedure used to remove pathologic substances from a patient's blood that has proven useful in some cases of drug overdose...
  60. ncbi Infliximab plus plasma exchange rescue therapy in Kawasaki disease
    Kaori Sonoda
    Department of Pediatrics, Yokohama City University, School of Medicine Yokohama, Japan
    J Pediatr 164:1128-1132.e1. 2014
    ..infliximab (IFX) in patients with Kawasaki disease (KD) that was unresponsive to additional intravenous immunoglobulin (IVIG) therapy and subsequent rescue with supplementary plasma exchange (PE) in patients unresponsive to treatment.
  61. ncbi [Plasma exchange support therapy in icterohemorrhagic leptospirosis]
    Carlos Homs
    Enferm Infecc Microbiol Clin 21:166-7. 2003
  62. ncbi Thrombocytopenic purpura and cardiomyopathy in pregnancy reversed by combined plasma exchange and infusion
    Elizabeth M Cosmai
    Division of Hematology Oncology, University of Miami and Veterans Affairs Medical Center, Florida, USA
    Eur J Haematol 68:239-42. 2002
    ..The suspicion of TTP was raised, and plasma exchange was begun by the third hospital day...
  63. ncbi Effect of plasma exchange on the circulating IL-6 levels in a patient with fatal hemophagocytic syndrome associated with bile ductopenia
    Kyung Soon Song
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
    Ther Apher Dial 10:87-9. 2006
    ..Liver biopsy showed centrilobular cholestasis with lack of interlobular bile duct. Repeated therapeutic plasma exchange was effective for decreasing serum bilirubin and interleukin-6 levels...
  64. ncbi Long-term survivors with artificial liver support in fulminant hepatic failure
    Masakazu Nitta
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ther Apher 6:208-12. 2002
    ..Thus, further investigation will be needed to establish a consensus on indications for long-term ALS in FHF...
  65. ncbi Artificial liver support at present and in the future
    Kazuhiko Onodera
    Department of Surgery, Sapporo Hokuyu Hospital, Research Institute for Artificial Organs, Transplantation and Gene Therapy, 6 6 5 1 Higashi Sapporo, Shiroishi ku, Sapporo, 003 0006, Japan
    J Artif Organs 9:17-28. 2006
    ..Practically speaking, we believe that plasma exchange (PE) and continuous hemodiafiltration (CHDF) are the most effective therapies for the treatment of liver ..
  66. ncbi Factors associated with the effectiveness of plasma exchange for the treatment of NMO-IgG-positive neuromyelitis optica spectrum disorders
    Young Min Lim
    Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Mult Scler 19:1216-8. 2013
    To identify factors associated with plasma exchange response in neuromyelitis optica (NMO) spectrum disorders, the clinical and magnetic resonance imaging (MRI) features of 31 NMO-IgG-positive patients receiving plasma exchange for ..
  67. ncbi Artificial liver support system in China: a review over the last 30 years
    Lan Juan Li
    Key Laboratory of Infectious Diseases, Ministry of Public Health, Department of Infectious Disease, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Ther Apher Dial 10:160-7. 2006
    ..Following 10 years of development in China, a plasma exchange (PE)-centered artificial liver support system (ALSS), principally dependent on PE technology was developed...
  68. ncbi Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months
    S Llufriu
    Neurology Service, Hospital Clinic, Universitat de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer, 08036 Barcelona, Spain
    Neurology 73:949-53. 2009
    b>Plasma exchange (PE) is used to treat severe episodes of CNS demyelination unresponsive to corticosteroids. Predictors of long-term response are not well known.
  69. ncbi Comparison of citrate anticoagulation during plasma exchange with different replacement solutions
    Manja Antonic
    Department of Nephrology, University Medical Center Ljubljana, SI 1000 Ljubljana, Slovenia
    Ther Apher Dial 13:322-6. 2009
    ..study was to compare the application of regional citrate anticoagulation and citrate-related side-effects in plasma exchange (PE) with different replacement solutions...
  70. ncbi Sonoclot coagulation analysis and plasma exchange in a case of meningococcal septicaemia
    U Schott
    Department of Anesthesia and Intensive Care, Orebro Medical Center Hospital, Sweden
    Can J Anaesth 42:64-8. 1995
    ..the diagnostic potential of a clot impedance test - Sonoclot coagulation analysis - was used to evaluate plasma exchange. A 17-yr-old girl was treated for a fulminant infection with Neisseria meningitidis in our intensive care ..
  71. ncbi Plasma exchange for Guillain-Barré syndrome
    Jean Claude Raphael
    Hopital Raymond Poincare, Garches, France
    Cochrane Database Syst Rev 7:CD001798. 2012
    ..Guillain-Barré syndrome is an acute paralysing disease caused by peripheral nerve inflammation. This is an update of a review first published in 2001 and last updated in 2008...
  72. ncbi A case report of successful treatment with plasma exchange for hemophagocytic syndrome associated with severe systemic juvenile idiopathic arthritis in an infant girl
    Hyogo Nakakura
    Department of Pediatrics, Osaka Medical College, Osaka, Japan
    Ther Apher Dial 13:71-6. 2009
    ..refractory to methylprednisolone pulse therapy and cyclosporine A administration, was successfully treated by plasma exchange. The patient was a one-year-old Japanese girl who had developed recurrent steroid-dependent signs, including ..
  73. ncbi Plasma exchange: why we do what we do
    Mark E Brecher
    Department of Pathology and Laboratory Medicine, Transfusion Medicine Service, University of North Carolina at Chapel Hill, NC 27514, USA
    J Clin Apher 17:207-11. 2002
  74. ncbi The role of therapeutic plasma exchange in the catastrophic antiphospholipid syndrome
    Imad Uthman
    Department of Internal Medicine, Division of Rheumatology, American University of Beirut Medical Center AUBMC, Hamra Street, Beirut 1107 2802, Lebanon
    Transfus Apher Sci 33:11-7. 2005
    ..The optimal treatment regimen for CAPS is unknown. To evaluate the benefit of therapeutic plasma exchange (TPE) therapy in CAPS, we undertook a computer-assisted (MEDLINE, National Library of Medicine, Bethesda, MD) ..
  75. pmc Acute neurological involvement in diarrhea-associated hemolytic uremic syndrome
    Sylvie Nathanson
    Pediatric Unit, Hôpital Mignot, 177 rue de Versailles, F 78150 le Chesnay, France
    Clin J Am Soc Nephrol 5:1218-28. 2010
    ..Neurologic involvement is the most threatening complication of diarrhea-associated hemolytic uremic syndrome (D+HUS)...
  76. ncbi Plasma exchange for anti GAD associated non paraneoplastic limbic encephalitis
    Gustavo Mazzi
    Servizio di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliera Santa Maria degli Angeli Via Montereale 24, 33170 Pordenone, Italy
    Transfus Apher Sci 39:229-33. 2008
    ..The use of therapeutic plasma exchange (TPE) has resulted in an improvement in symptoms with quite a long disease-free period of time...
  77. ncbi Plasma exchange and immunoadsorption for autoimmune neurologic diseases - current guidelines and future perspectives
    Reinhard Klingel
    Apheresis Research Institute, Cologne, Germany
    Atheroscler Suppl 10:129-32. 2009
    ..b>Plasma exchange (PE) as the classical method has become part of current guidelines within basic and escalating ..
  78. ncbi Plasma exchange conditioning for ABO-incompatible renal transplantation
    J L Winters
    Department of Laboratory Medicine and Pathology, Division of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Apher 19:79-85. 2004
    ..Isoagglutinin titers and scores were determined before and after each plasma exchange. Transplant outcomes were determined. Twenty-six ABO-incompatible transplants were performed...
  79. ncbi The course of ADAMTS-13 activity and inhibitor titre in the treatment of thrombotic thrombocytopenic purpura with plasma exchange and vincristine
    Martina Bohm
    Department of Internal Medicine, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
    Br J Haematol 129:644-52. 2005
    The therapeutic efficacy of plasma exchange (PE) in thrombotic thrombocytopenic purpura (TTP) is attributed to the restoration in ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin motif-13) activity by substitution of ..
  80. ncbi Effect of different LDL-apheresis methods on parameters involved in atherosclerosis
    Tiberiu Hershcovici
    Lipid Unit, and Department of Medicine A, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    J Clin Apher 19:90-7. 2004
    ..The present study compared three apheresis methods--DSA, DALI, and plasma exchange--for effectiveness in removal of LDL and effect on various blood parameters involved in atherogenesis...
  81. ncbi Retrospective study of plasma exchange in children with systemic lupus erythematosus
    Elizabeth C Wright
    Renal Unit, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1 N 3JH, UK
    Pediatr Nephrol 19:1108-14. 2004
    A retrospective review of patients was conducted to evaluate the short-term effect of therapeutic plasma exchange (TPE) in children with active systemic lupus erythematosus (SLE)...
  82. ncbi Effect of plasma exchange on hepatocyte oxidative stress, mitochondria function, and apoptosis in patients with acute fatty liver of pregnancy
    Wanxin Tang
    Divisions of Nephrology Gastroenterology, West China Hospital of Sichuan University Division of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Guo Xue Alley 37, Sichuan, China
    Artif Organs 36:E39-47. 2012
    ..Traditional therapy is inadequate for patients with severe conditions so the application of plasma exchange (PE) has been attempted...
  83. ncbi Effectiveness of combining plasma exchange with continuous hemodiafiltration on acute Fatty liver of pregnancy complicated by multiple organ dysfunction
    Yu Feng Chu
    Department of Medical Intensive Care Unit, Provincial Hospital Shandong University, Shandong Tumor Hospital, No 324 Jingwu Road, Jinan, China
    Artif Organs 36:530-4. 2012
    ..The application of combining plasma exchange (PE) and continuous hemodiafiltration (CHDF) is a novel concept for patients with AFLP...
  84. ncbi Frequency and significance of schistocytes in TTP/HUS patients at the discontinuation of plasma exchange therapy
    Jennifer A Egan
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    J Clin Apher 19:165-7. 2004
    ..Standard of care is daily plasma exchange, which is typically discontinued when the platelet count exceeds 100-150 x 10(9)/L for 2 days...
  85. ncbi Lesion pathology predicts response to plasma exchange in secondary progressive MS
    U K Zettl
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
    Neurology 67:1515-6. 2006
  86. ncbi Plasma exchange in severe hypertriglyceridemia a clinical study
    Gurhan Kadikoylu
    Adnan Menderes University Medical Faculty, Division of Hematology, Tip Fakultesi, Ic Hastaliklari AD, Aydin, Turkey
    Transfus Apher Sci 34:253-7. 2006
    ..Hypercholesterolemia and hypertriglyceridemia are independent risk factors for atherosclerotic heart diseases. Moreover acute pancreatitis may occur in patients with severe hypertriglyceridemia...
  87. ncbi Treatment of thrombotic microangiopathies with plasma exchange
    Nikolina Basic-Jukic
    Department of Dialysis, University Hospital Centre Zagreb, Zagreb, Croatia
    Hematology 12:63-7. 2007
    ..analysis sought to determine the clinical characteristics and outcome of patients with TMA treated with plasma exchange at the Department of Dialysis, University Hospital Zagreb...
  88. ncbi Plasma exchange and rituximab in the management of acute occlusive retinal vasculopathy secondary to systemic lupus erythematosus
    Erika Damato
    Bristol Eye Hospital, Lower Maudlin Street, Bristol, UK
    Ocul Immunol Inflamm 19:379-81. 2011
    To report a case of acute occlusive retinal vasculopathy secondary to systemic lupus erythematosus (SLE) successfully treated with plasma exchange and rituximab
  89. ncbi Artificial liver support system for fulminant hepatic failure as bridge-use to living donor liver transplantation
    Takafumi Ichida
    Intern Med 42:920-1. 2003
  90. ncbi Plasma exchange and intravenous immunoglobulins: mechanism of action in immune-mediated neuropathies
    Helmar C Lehmann
    Medical Faculty, Department of Neurology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    J Neuroimmunol 231:61-9. 2011
    ..b>Plasma exchange (PE) and intravenous immunoglobulins (IVIg) are mainstays in the treatment of immune-mediated neuropathies...
  91. ncbi Preoperative therapeutic plasma exchange in patients with thyrotoxicosis
    Ali Ezer
    Department of General Surgery, Baskent University, Ankara, Turkey
    J Clin Apher 24:111-4. 2009
    The purpose of this report was to determine the effectiveness of therapeutic plasma exchange (TPE) in preoperative preparation of patients with thyrotoxicosis scheduled for either thyroid or nonthyroid surgery...
  92. ncbi Changes of serum cytokine levels in patients with acute on chronic liver failure treated by plasma exchange
    Wei lin Mao
    Department of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China
    J Clin Gastroenterol 45:551-5. 2011
    Acute on chronic liver failure (AoCLF) is associated with a high mortality rate. Plasma exchange (PE) may be useful to bridge patients with AoCLF to liver transplantation or to regenerate their own livers...
  93. ncbi Management of familial hypertriglyceridemia during pregnancy with plasma exchange
    Praveen Sivakumaran
    Division of Transfusion Medicine, Pathology and Lab Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Apher 24:42-6. 2009
    ..We report the successful use of therapeutic plasma exchange (TPE) in the management of hypertriglyceridemia during pregnancy resulting in avoidance of pancreatitis and ..
  94. ncbi ABO blood type incompatible kidney transplantation without splenectomy prepared with plasma exchange and rituximab
    T Chikaraishi
    Department of Urology, St Marianna University, Kawasaki, Kanagawa, Japan
    Transplant Proc 40:3445-7. 2008
    ..There were no side effects. All patients have renal transplant function with a follow-up of 1-34 months...
  95. ncbi Cytokine removal by plasma exchange with continuous hemodiafiltration in critically ill patients
    Hajime Nakae
    Department of Emergency and Critical Care Medicine, Akita University School of Medicine, Akita, Japan
    Ther Apher 6:419-24. 2002
    The effectiveness of plasma exchange (PE) with continuous hemodiafiltration (CHDF) in the treatment of critically ill patients was evaluated based on changes in cytokine levels...
  96. ncbi Is therapeutic plasma exchange indicated for patients with gemcitabine-induced hemolytic uremic syndrome?
    Ethan McCaleb Gore
    University of South Alabama College of Medicine, Mobile, Alabama, USA
    J Clin Apher 24:209-14. 2009
    ..we discuss the diagnosis of gemcitabine-induced aHUS (GiHUS) and the published experience with therapeutic plasma exchange (TPE)...
  97. ncbi [Plasma exchange and continuous hemodiafiltration as an initial treatment for diffuse large B-cell lymphoma-associated hemophagocytic syndrome]
    Norimitsu Yanagiya
    Third Department of Internal Medicine, Akita University School of Medicine
    Rinsho Ketsueki 43:35-40. 2002
    ..9 mg/dl), ferritin (2,300 ng/ml) and sIL-2 receptor (36,900 U/ml). Plasma exchange (PE) and continuous hemodiafiltration (CHDF) enabled the patient to undergo diagnostic procedures, ..
  98. ncbi Prediction value of model for end-stage liver disease scoring system on prognosis in the acute on chronic liver failure patients with plasma exchange treatment
    Weilin Mao
    Department of Clinical Laboratory, The First Affiliated Hospital, Zhejiang University, Hangzhou, People s Republic of China
    ASAIO J 56:475-8. 2010
    Hepatitis B virus-related acute-on-chronic liver failure (AoCLF) is associated with a high mortality rate. Plasma exchange (PE) is useful to bridge patients with AoCLF to liver transplantation or recovery...
  99. ncbi A case report of successful treatment with plasma exchange for adult-onset Still's disease with autoimmune hepatitis
    Lin Lin Liu
    Department of Nephrology, The First Affiliated Hospital of China Medical University, People s Republic of China
    J Clin Apher 25:74-6. 2010
    ..AIH may be an indicator of the poor prognosis of AOSD. Herein we describe a case of successful treatment with plasma exchange for AOSD-associated AIH.
  100. ncbi Predictors of complications in therapeutic plasma exchange
    Carsten P Bramlage
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, 37075 Gottingen, Germany
    J Clin Apher 24:225-31. 2009
    b>Plasma exchange (PE) is used for blood purification to modulate proteins involved in pathological processes...
  101. ncbi Efficacy and safety of first-line rituximab in severe, acquired thrombotic thrombocytopenic purpura with a suboptimal response to plasma exchange. Experience of the French Thrombotic Microangiopathies Reference Center
    Antoine Froissart
    Service d Hématologie Clinique et de Thérapie Cellulaire, AP HP, Groupe Hospitalier Pitie Salpetriere, UPMC Univ Paris 6, Paris, France
    Crit Care Med 40:104-11. 2012
    ..To assess the efficacy and safety of rituximab in adults responding poorly to standard treatment for severe autoimmune thrombotic thrombocytopenic purpura...

Research Grants34

  1. SELECTIVE PLASMA EXCHANGE THERAPY
    Jacek Rozga; Fiscal Year: 2003
    ..Of all the strategies employed to date for the development of blood detoxification systems, only total plasma exchange therapy was shown to be clinically effective in reversing hepatic coma and improving blood coagulopathy...
  2. PANDAS and Strep Infection: Are they Linked?
    Roger Kurlan; Fiscal Year: 2004
    ..Disproving the PANDAS hypothesis would prevent the use of expensive and potentially dangerous therapies (e.g., plasma exchange, immune globulin, antibiotics) that have been proposed for PANDAS patients.
  3. Modeling Immune Desensitization in Renal Transplantation
    Martin S Zand; Fiscal Year: 2013
    ..IMDS proto- cols combine several therapies: (i) removal of circulating DSA by therapeutic plasma exchange (PLEX) (ii) pooled intravenous immunoglobulin (IVIG) therapy to alter the fractional catabolism of DSA, (iii) ..
  4. Alloantibodies in Cardiac Transplantation - Intervention, Outcomes and Mechanisms
    Steven A Webber; Fiscal Year: 2012
    ..The protocol will involve intra- and post- operative plasma exchange/pheresis and a uniform immunosuppressive protocol...
  5. Plasma Exchange and Glucocorticoids for Treatment of ANCA-Associated Vasculitis
    Peter A Merkel; Fiscal Year: 2011
    ..b>Plasma exchange, a method of removing potentially pathogenic antibodies, coagulation factors and inflammatory mediators has ..
  6. A Phase II Trial of Rituximab In Myasthenia Gravis
    Richard Nowak; Fiscal Year: 2013
    ..acetylcholinesterase inhibitors and immunotherapy such as corticosteroids, azathioprine, cyclosporine, and plasma exchange (PLEX) and intravenous immunoglobulin (IVIg)...
  7. Novel Therapeutics for Acquired Thrombotic Thrombocytopenic Purpura
    X Long Zheng; Fiscal Year: 2013
    ..Acquired TTP is mainly caused by autoantibodies that inhibit ADAMTS13 enzyme. Plasma exchange is the only effective therapy available to date...
  8. Ph 3 of Cyclosporine or Corticosteroids Adjunct to Plasma Exhcange in Tx of TTP
    Haifeng M Wu; Fiscal Year: 2013
    ..study entitled "A Multi-Center, Randomized Study of Cyclosporine (CSA) or Corticosteroids as an Adjunct to Plasma Exchange (PE) in Initial Therapy of TTP." (Neoral, IND# 78,687)...
  9. "Development of a Laboratory Test for TTP"
    Christopher Hillyer; Fiscal Year: 2003
    ..go undiagnosed, while others are misdiagnosed and subjected to costly therapy including daily therapeutic plasma exchange (about $1500 per treatment, 4 hrs per treatment x 7-14 days), that utilizes fresh frozen plasma as the plasma ..
  10. IMMUNE RESPONSE TO BREAST DUCTAL CARCINOMA IN SITU
    Scott Pruitt; Fiscal Year: 1999
    ..Should these techniques fail to deplete NAbs, plasma exchange or xenogeneic organ perfusion will be utilized in an effort to reduce NAb levels and prolong guinea pig ..
  11. A Prospective Longitudinal Study of PANDAS
    James Leckman; Fiscal Year: 2005
    ..patients with tic disorders and/or OCD; (2) enlarged basal ganglia in PANDAS cases; and (3) the finding that plasma exchange and intravenous immunoglobulin treatment are effective in reducing symptoms in PANDAS cases, this ..
  12. SECOND IMMUNOGLOULIN DOSE GBS TRIAL (SIDGBS TRIAL)
    David Cornblath; Fiscal Year: 1999
    Until recently, plasma exchange was the gold standard treatment for patients with Guillain-Barr syndrome (GBS)...
  13. PLASMA EXCHANGE IN SEVERE DEMYELINATING DISEASE
    Brian Weinshenker; Fiscal Year: 1999
    ..Following dramatic success with plasma exchange in their uncontrolled experience, the investigators propose to conduct a double-blind, placebo controlled, ..
  14. Clinical Research Training Institute
    James George; Fiscal Year: 2005
    ..It is through this near one to one ratio with the trainees that ASH intends to foster and sustain interest in clinical hematologic research and thereby help stimulate the career development of future clinical researchers in hematology. ..
  15. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  16. Experimental Dysautonomia: Pathogenesis and Treatment
    Steven Vernino; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  17. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  18. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  19. Phase 3 stem cell transplant for light chain amyloidosis
    Morie A Gertz; Fiscal Year: 2011
    ..In addition, the analysis of clonal precursor B cells in the periphery and kinetics of amyloid formation of the monoclonal light chain will allow us to define and determine the mechanisms of disease progression and response to therapy. ..
  20. RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    Bruce Zuraw; Fiscal Year: 2002
    ..These results will provide a necessary foundation for additional investigations into downstream inflammatory consequences of rhinovirus infection as well as potential targets for new intervention strategies. ..
  21. ANGIOSTATIN--MOLECULAR MECHANISMS AND INTERACTIONS
    DAVID SANE; Fiscal Year: 2002
    ..These studies will lead to a better understanding of the mechanisms of angiogenesis inhibition by angiostatin. ..
  22. VLA4 IN CTL MEDIATED ISLET ALLOGRAFT REJECTION
    Mark Stegall; Fiscal Year: 2001
    ..The approach may lead to novel forms of immune suppression that may benefit not only islet transplantation, but also other types of organ allografts. ..
  23. Henoch Schonlein Purpura and Corticosteroid Treatment
    PAMELA WEISS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  24. Structure and Function of ADAMTS13 Metalloprotease
    X Long Zheng; Fiscal Year: 2009
    ....
  25. Interferon Gamma Polymorphisms and Gender Bias in MS
    Brian Weinshenker; Fiscal Year: 2004
    ..If successful, this paradigm could be applied to a number of similar genetic association studies. ..
  26. Polymorphisms of Antiphospholipid Protein Antigens
    Joan Merrill; Fiscal Year: 2005
    ..Additionally, the study of differences in interactions between these coagulation proteins conferred by common, inherited polymorphisms will have intrinsic value, not limited to the antiphospholipid syndrome. ..
  27. Immune Parameters in a Steroid Sparing Clinical Trial
    Nancy Reinsmoen; Fiscal Year: 2005
    ..Thus, the overall study is designed to use immune parameters to identify recipients at low vs. high risk for poor graft outcome, thereby allowing for individualization of immunosuppression aimed at improving long-term graft outcome. ..
  28. Family Based Treatment of Early Childhood OCD
    Henrietta Leonard; Fiscal Year: 2004
    ..At the end of the study, a final revised, comprehensive, manualized treatment protocol would be completed which could be tested in large efficacy and effectiveness studies. ..
  29. SPORADIC MECHANISM OF THE ANTIPHOSPHOLIPID SYNDROME
    Joan Merrill; Fiscal Year: 2001
    ..Therefore, possible modulation by sex-hormones of interactions between these proteins will be addressed in this application. ..
  30. Cognitive Effects of Cerebellar Lesions in Humans
    JEREMY SCHMAHMANN; Fiscal Year: 2006
    ..This study has implications for the recognition and treatment of disorders of higher order function in cerebellar patients. [unreadable] [unreadable]..
  31. GILZ Controls TLR-Induced NF-kB Activity In Acute Asthma
    Bruce Zuraw; Fiscal Year: 2008
    ..We anticipate that this proposal will provide novel and clinically relevant data regarding the mechanisms of acute asthma exacerbations. ..
  32. ADAMTS13 Deficiency in TTP
    Han Mou Tsai; Fiscal Year: 2008
    ..The use of plasma exchange has improved the survival rate of the disease from <10% to 80% -90%...
  33. Inhibitors of ADAMTS313 and Outcome of TTP
    Han Mou Tsai; Fiscal Year: 2004
    ..The incidence is estimated to be 4-30 cases/million/year. Plasma exchange has been the mainstay of treatment for TTP, preventing a fatal outcome in 70%-90% of the cases...