platelet transfusion

Summary

Summary: The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.

Top Publications

  1. ncbi Platelet immunopathology and therapy: a Canadian Blood Services Research and Development Symposium
    Alan T Tinmouth
    Adult Region Hemophilia Bleeding Disorders Comprehensive Care Clinic, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
    Transfus Med Rev 20:294-314. 2006
  2. pmc Optimizing the use of blood products in trauma care
    John R Hess
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Crit Care 9:S10-4. 2005
  3. ncbi Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients
    N A Murray
    Department of Neonatal Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Queen Charlotte s and Chelsea Hospital, London, UK
    Transfus Med 12:35-41. 2002
  4. ncbi Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey
    Cassandra D Josephson
    Aflac Cancer Center and Blood Disorders Services at Children s Healthcare of Atlanta, Atlanta, Georgia, USA
    Pediatrics 123:278-85. 2009
  5. ncbi Prospective observational study of low thresholds for platelet transfusion in adult dengue patients
    Laurent Thomas
    Service des Urgences, Hopital Pierre Zobda Quitman, Centre Hospitalier Universitaire, Fort de France, Martinique
    Transfusion 49:1400-11. 2009
  6. pmc In vitro megakaryocyte production and platelet biogenesis: state of the art
    Jo Anna Reems
    Puget Sound Blood Center, Seattle, WA 98104, USA
    Transfus Med Rev 24:33-43. 2010
  7. pmc Measurement of the absolute immature platelet number reflects marrow production and is not impacted by platelet transfusion
    Taha Bat
    Hematology Branch, National Heart, Lung, and BloodInstitute, National Institutes of Health, Bethesda, MD 20892, USA
    Transfusion 53:1201-4. 2013
  8. ncbi Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study
    Hannes Wandt
    Medical Clinic 5, Haematology and Oncology, Klinikum Nuremberg, Nuremberg, Germany
    Lancet 380:1309-16. 2012
  9. ncbi Platelet transfusion improves liver function in patients with chronic liver disease and cirrhosis
    Takehito Maruyama
    Department of Surgery, Division of Gastroenterological and Hepatobiliary Surgery, and Organ Transplantation, University of Tsukuba, Ibaraki, Japan
    Tohoku J Exp Med 229:213-20. 2013
  10. ncbi Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation
    Lise Estcourt
    Haematology Transfusion Medicine, NHS Blood and Transplant, Oxford, UK
    Cochrane Database Syst Rev 5:CD004269. 2012

Detail Information

Publications243 found, 100 shown here

  1. ncbi Platelet immunopathology and therapy: a Canadian Blood Services Research and Development Symposium
    Alan T Tinmouth
    Adult Region Hemophilia Bleeding Disorders Comprehensive Care Clinic, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
    Transfus Med Rev 20:294-314. 2006
  2. pmc Optimizing the use of blood products in trauma care
    John R Hess
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Crit Care 9:S10-4. 2005
    ..Less developed trauma systems are primarily concerned with speeding transport to specialized facilities and assembling trauma center resources. This article reviews the factors that effect blood use in urgent trauma care...
  3. ncbi Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients
    N A Murray
    Department of Neonatal Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Queen Charlotte s and Chelsea Hospital, London, UK
    Transfus Med 12:35-41. 2002
    ..To address this we conducted a retrospective review of platelet transfusion practice in patients developing severe thrombocytopenia over 3 years in a single NICU...
  4. ncbi Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey
    Cassandra D Josephson
    Aflac Cancer Center and Blood Disorders Services at Children s Healthcare of Atlanta, Atlanta, Georgia, USA
    Pediatrics 123:278-85. 2009
    In the absence of scientific evidence, current neonatal platelet transfusion practices are based on physicians' preferences, expert advice, or consensus-driven recommendations...
  5. ncbi Prospective observational study of low thresholds for platelet transfusion in adult dengue patients
    Laurent Thomas
    Service des Urgences, Hopital Pierre Zobda Quitman, Centre Hospitalier Universitaire, Fort de France, Martinique
    Transfusion 49:1400-11. 2009
    ..Because many patients were found to have received unnecessary PLT transfusions, the development of guidelines for the management of dengue patients with thrombocytopenia has become a necessity...
  6. pmc In vitro megakaryocyte production and platelet biogenesis: state of the art
    Jo Anna Reems
    Puget Sound Blood Center, Seattle, WA 98104, USA
    Transfus Med Rev 24:33-43. 2010
    ....
  7. pmc Measurement of the absolute immature platelet number reflects marrow production and is not impacted by platelet transfusion
    Taha Bat
    Hematology Branch, National Heart, Lung, and BloodInstitute, National Institutes of Health, Bethesda, MD 20892, USA
    Transfusion 53:1201-4. 2013
    ..The measurement of immature circulating PLTs based on RNA content using an automated counter is now feasible. This study evaluated the impact of recent PLT transfusion on measurement of immature PLT variables...
  8. ncbi Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study
    Hannes Wandt
    Medical Clinic 5, Haematology and Oncology, Klinikum Nuremberg, Nuremberg, Germany
    Lancet 380:1309-16. 2012
    Routine prophylactic platelet transfusion is the standard of care for patients with severe thrombocytopenia...
  9. ncbi Platelet transfusion improves liver function in patients with chronic liver disease and cirrhosis
    Takehito Maruyama
    Department of Surgery, Division of Gastroenterological and Hepatobiliary Surgery, and Organ Transplantation, University of Tsukuba, Ibaraki, Japan
    Tohoku J Exp Med 229:213-20. 2013
    ..Thus, to investigate whether platelet transfusion improves liver function in patients with CLD and cirrhosis, we conducted an exploratory clinical trial...
  10. ncbi Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after chemotherapy and stem cell transplantation
    Lise Estcourt
    Haematology Transfusion Medicine, NHS Blood and Transplant, Oxford, UK
    Cochrane Database Syst Rev 5:CD004269. 2012
    ..Although considerable advances have been made in platelet transfusion therapy in the last 40 years, some areas continue to provoke debate especially concerning the use of ..
  11. ncbi Origins of platelet transfusion therapy
    Emil J Freireich
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Transfus Med Rev 25:252-6. 2011
    ..Platelet replacement for thrombocytopenia prevents the hemorrhagic diathesis and has been universally practiced for over 50 years...
  12. ncbi Platelet transfusion refractoriness in highly immunized beta thalassemia children undergoing stem cell transplantation
    Sarah Marktel
    Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy
    Pediatr Transplant 14:393-401. 2010
    Immune-mediated refractoriness to platelet transfusion is a major problem in patients undergoing HSCT...
  13. ncbi Platelet transfusion during liver transplantation is associated with increased postoperative mortality due to acute lung injury
    Ilona T A Pereboom
    Department of Surgery, Section Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, The Netherlands
    Anesth Analg 108:1083-91. 2009
    ..In this study, we analyzed the specific causes of mortality and graft loss in relation to platelet transfusions during OLT...
  14. ncbi Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet-rich plasma: tissue-engineered bone regeneration
    Yoichi Yamada
    Center for Genetic and Regenerative Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Tissue Eng 10:955-64. 2004
    ..4 +/- 3.38% (PCBM), and 67.3 +/- 2.06% (dMSCs/PRP). There were significant differences between the PCBM, dMSCs/PRP, and control groups. These results demonstrate that the dMSCs/PRP mixture is useful as a osteogenic bone substitute...
  15. ncbi Automatic detection of immature platelets for decision making regarding platelet transfusion indications for pediatric patients
    Katsuyasu Saigo
    Blood Transfusion Division, Kobe University Hospital, Chuo Ku, Kobe 650 0017, Japan
    Transfus Apher Sci 38:127-32. 2008
    ..Our results indicate that IPF should be considered a useful marker of imminent platelet recovery so that unnecessary platelet transfusion can be avoided.
  16. ncbi Development of a novel large animal model of ischemic heart failure using autologous platelet aggregates
    Pawel Kwiatkowski
    Department of Surgery, The Ohio State University Medical Center, Columbus, OH, USA
    Int J Artif Organs 33:63-71. 2010
    ..We propose a novel animal model of ischemic cardiomyopathy developed by sequential direct injections of autologous platelet aggregates into the coronary circulation resulting in development of ischemic cardiac insufficiency...
  17. ncbi Strategies of bacteria screening in cellular blood components
    Thomas Montag
    Paul Ehrlich Institute, Section Microbial Safety, Langen, Germany
    Clin Chem Lab Med 46:926-32. 2008
    ..Considering the sum of different aspects including the supply of patients, the potential improvement of microbial safety of platelet concentrates is comparable in both strategies...
  18. ncbi Utility of platelet transfusion in adult patients with traumatic intracranial hemorrhage and preinjury antiplatelet use: a systematic review
    Daniel K Nishijima
    Departments of Emergency Medicine, School of Medicine, University of California, Davis, Sacramento, California 95817 2282, USA
    J Trauma Acute Care Surg 72:1658-63. 2012
    ..Some investigators have recommended platelet transfusion to reverse the antiplatelet effects in tICH...
  19. pmc CD40 ligand (CD154) involvement in platelet transfusion reactions
    J Sahler
    Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, 601, Elmwood Avenue Rochester, New York 14642, USA
    Transfus Clin Biol 19:98-103. 2012
    ....
  20. pmc Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury
    Xuan Chi
    Laboratory of Cellular Hematology, Division of Hematology, OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America
    PLoS ONE 7:e44829. 2012
    ..Neutrophils also recruited a small percentage of platelets to the lung. These findings may help develop therapeutic strategies for ALI which could potentially result from transfusion of UV illuminated platelets...
  21. ncbi Platelet transfusion and survival in adults with acute leukemia
    N Blumberg
    Leukemia 22:631-5. 2008
  22. ncbi Impact of preoperative right-ventricular function and platelet transfusion on outcome after lung transplantation
    Marco P Zalunardo
    Institute of Anaesthesiology, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Eur J Cardiothorac Surg 39:538-42. 2011
    ..We investigated the impact of poor preoperative right-ventricular function and blood-product use on outcome after lung transplantation...
  23. ncbi Immunomodulatory mediators in platelet transfusion reactions
    Craig N Morrell
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Hematology Am Soc Hematol Educ Program 2011:470-4. 2011
    ..One of the major roles of platelets is in initiating and accelerating immune responses. Platelet transfusion may be associated with adverse inflammatory outcomes manifested as fever, discomfort, tachycardia, and ..
  24. ncbi Strategies for transfusion therapy
    Donat R Spahn
    Department of Anesthesiology, University Hospital Lausanne Chuv, CH 1011 Lausanne, Switzerland
    Best Pract Res Clin Anaesthesiol 18:661-73. 2004
    ....
  25. ncbi Platelet transfusion threshold in patients with upper gastrointestinal bleeding: a systematic review
    Anoush Razzaghi
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Clin Gastroenterol 46:482-6. 2012
    ..GOALS AND STUDY: A systematic review was carried out to determine the optimal approach when managing patients with thrombocytopenia in the setting of nonvariceal upper GI bleeding...
  26. ncbi In vivo recovery of human platelets in severe combined immunodeficient mice as a measure of platelet damage
    John T Piper
    Laboratory of Cellular Hematology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA
    Transfusion 47:1540-9. 2007
    ..The severe combined immunodeficient (SCID) mice allowed prolonged circulation of human PLTs and were used to detect differences in recovery and survival between chemically damaged, aged PLTs, or normal PLTs...
  27. ncbi The first probable case of platelet transfusion-transmitted visceral leishmaniasis
    P Mathur
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    Transfus Med 14:319-21. 2004
    ..causing VL, reports of transfusion-transmitted infections are rare. A case of probable platelet transfusion-acquired VL is reported from India and issues related to transfusion safety in endemic areas are discussed.
  28. ncbi Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings
    F Weissinger
    Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, USA
    Blood 98:3584-8. 2001
    Red blood cell (RBC) and platelet transfusion requirements in patients given nonmyeloablative versus conventional peripheral blood stem cell (PBSC) transplants from HLA-matched siblings were compared...
  29. ncbi Platelet utilization in the developing world: strategies to optimize platelet transfusion practices
    Anupam Verma
    Transfusion Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    Transfus Apher Sci 41:145-9. 2009
    ..This is in sharp contrast to the fast pace of development in platelet transfusion practice in developed world where platelet substitutes are to become a reality for clinical use in near ..
  30. ncbi Analysis of transfusion reactions associated with prestorage-pooled platelet components
    Christopher A Tormey
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Transfusion 49:1242-7. 2009
    ....
  31. ncbi Improved haematopoietic recovery following transplantation with ex vivo-expanded mobilized blood cells
    H Miles Prince
    Division of Haematology and Medical Oncology, Peter MacCallum Cancer Center, Melbourne, Australia
    Br J Haematol 126:536-45. 2004
    ..There were also fewer platelet transfusions required (43% vs. 100%; P = 0.009). We conclude that EXE cells enhance both neutrophil and platelet recovery and reduce febrile neutropenia, platelet transfusion and hospital re-admission.
  32. ncbi Effectiveness of washed platelet concentrate and red cell transfusions for a patient with anhaptoglobinemia with antihaptoglobin antibody
    S Nishiki
    Department of Clinical Hematology and Diagnostics, Osaka City University, Graduate School of Medicine, Japan
    Transfus Med 12:71-3. 2002
    ..No antibodies against human leucocyte antigen (HLA) or platelet-specific antigens were detected. Washed PC and washed red blood cells were effective in preventing the transfusion-related anaphylactoid reactions...
  33. ncbi Platelet transfusion and adverse outcomes
    Eleftherios C Vamvakas
    Canadian Blood Services, Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON K1 G 4 J5, Canada
    Lancet 364:1736-8. 2004
  34. ncbi Optimizing platelet transfusion therapy
    Joanna Mary Heal
    Hematology Oncology Unit, Department of Medicine, University of Rochester Medical Center, 601 Elwood Avenue, Box 608, Rochester, NY 14642, USA
    Blood Rev 18:149-65. 2004
    ..that leukoreduced and ABO identical platelet transfusions reduce the risks of HLA alloimmunization and platelet transfusion refractoriness (both leukoreduction and ABO matching), transfusion reactions (leukoreduction) and CMV ..
  35. ncbi Pooled platelet concentrates: an alternative to single donor apheresis platelets?
    R N I Pietersz
    Sanquin Blood Bank North West Region, Amsterdam, The Netherlands
    Transfus Apher Sci 41:115-9. 2009
    ..In conclusion the final products of LR-PC derived from whole blood or obtained by apheresis can be comparable, provided the critical steps of the processing method are identified and covered and the process is in control...
  36. ncbi Clinical safety of platelets photochemically treated with amotosalen HCl and ultraviolet A light for pathogen inactivation: the SPRINT trial
    Edward Snyder
    Yale University Medical School, Yale New Haven Hospital, New Haven, Connecticut, USA
    Transfusion 45:1864-75. 2005
    ..Hemostatic equivalency was demonstrated. The proportion of patients with Grade 2 bleeding was not inferior for PCT PLTs...
  37. ncbi Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion
    Peter H Lapchak
    Rheumatology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 302:G888-97. 2012
    ..that villi and lung damage are reduced in mice made platelet deficient before I/R injury and that platelet transfusion into previously platelet-depleted mice before I/R increased both villi and lung tissue damage...
  38. ncbi Ultraviolet B light-exposed human platelets mediate acute lung injury in a two-event mouse model of transfusion
    Monique P Gelderman
    Laboratory of Cellular Hematology, Division of Hematology, OBRR, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20892, USA
    Transfusion 51:2343-57. 2011
    ..Clinical trials of UV-treated PLTs in patients with thrombocytopenia generated controversy regarding association of these cells with respiratory distress. We evaluated whether UVB PLTs could mediate ALI in an animal model of ALI...
  39. ncbi Platelet transfusion for patients with cancer: clinical practice guidelines of the American Society of Clinical Oncology
    C A Schiffer
    Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit MI, USA
    J Clin Oncol 19:1519-38. 2001
    ..Keywords included platelet transfusion, alloimmunization, hemorrhage, threshold and thrombocytopenia...
  40. ncbi Platelet washing to prevent recurrent febrile reactions to leucocyte-reduced transfusions
    T D Vo
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center and Strong Memorial Hospital, NY 14642, USA
    Transfus Med 11:45-7. 2001
    ..These results support the hypothesis that substances present in the supernatant of stored platelet concentrates mediate febrile nonhaemolytic transfusion reactions, and provide one strategy for preventing their occurrence...
  41. pmc Coronary artery bypass grafting in idiopathic thrombocytopenia: use of thromboelastometry without platelet transfusion
    Michele Rossi
    Department of Cardiac Surgery, Royal Sussex University Hospital, Brighton BN2 5BE, United Kingdom
    Tex Heart Inst J 37:361-4. 2010
    ..We believe that point-of-care coagulation tests such as thromboelastometry warrant further evaluation regarding their usefulness in the clinical decision of whether to transfuse platelets and other blood products...
  42. ncbi Single-donor platelets reduce the risk of septic platelet transfusion reactions
    P Ness
    Departments of Pathology and Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Transfusion 41:857-61. 2001
    Septic platelet transfusion reactions (SPTRs) are the most common, serious risk of transfusion...
  43. ncbi Platelet transfusion refractoriness associated with HPA-1a (Pl(A1)) alloantibody without coexistent HLA antibodies successfully treated with antigen-negative platelet transfusions
    P A Pappalardo
    Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
    Transfusion 41:984-7. 2001
    BACKGROUND: Alloimmune-mediated refractoriness to platelet transfusion is most commonly due to antibody to HLA antigens in multiply transfused or multiparous patients...
  44. ncbi Platelet transfusion trigger in difficult patients
    P Rebulla
    Centro Trasfusionale e di Immunologia dei Trapianti, IFCCS Ospedale Maggiore, Milan, Italy
    Transfus Clin Biol 8:249-54. 2001
    ..Guidelines on the trigger and other issues related to platelet transfusion can be found in nine documents published during 1987-2001 by the National Institutes of Health (NIH), the ..
  45. ncbi Control of severe bleeding episode in case of Glanzmann's thrombasthenia refractory to platelet transfusion therapy by administering recombinant factor VIIa
    Asim Javed
    Combined Military Hospital, Rawalpindi, Pakistan
    J Ayub Med Coll Abbottabad 21:171-3. 2009
    ..with multiple platelet concentrate transfusions and recently admitted with severe epistaxis refractory to platelet transfusion. At this stage administration of recombinant activated factor VII (fVIIa) was considered, which was ..
  46. pmc The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantation
    Zejing Wang
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
    Br J Haematol 149:101-10. 2010
    ..ABO incompatibility did not affect nonmyeloablative HCT outcomes...
  47. ncbi New strategies for prophylactic platelet transfusion in patients with hematologic diseases
    H Wandt
    5th Medical Department and Institute of Medical Oncology and Hamatology, Nuremberg, Germany
    Oncologist 6:446-50. 2001
    ..There has been a long-lasting debate over whether the traditional threshold for prophylactic platelet transfusion of 20,000/microl is really necessary to prevent hemorrhagic complications...
  48. ncbi Platelet transfusion can be related to liver regeneration after living donor liver transplantation
    Joohyun Kim
    Department of Surgery, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, 1 Hoegi dong, Dongdaemun Gu, Seoul, 130 702, Republic of Korea
    World J Surg 34:1052-8. 2010
    ..Recently it was suggested that platelets contribute to liver regeneration. The aim of the present study was to identify the major factors that affect liver graft regeneration during the early post-transplantation period...
  49. pmc Dengue hemorrhagic fever in Trinidad and Tobago: a case for a conservative approach to platelet transfusion
    Anu Sharma
    Department of Clinical Medical Sciences, University of the West Indies, St Augustine, Trinidad and Tobago
    Am J Trop Med Hyg 86:531-5. 2012
    ..thrombocytopenic; 13 patients showed development of minor hemorrhage and only one case of major hemorrhage; platelet transfusion was given for 7% (13) of the cases; and 6 cases for which platelet transfusion was given did not show ..
  50. ncbi When less is more: can we abandon prophylactic platelet transfusion in Dengue fever?
    Changa Kurukularatne
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore
    Ann Acad Med Singapore 40:539-45. 2011
    ..Prophylactic platelet transfusion-in the absence of major bleeding-is utilized in DF with thrombocytopenia with the intention of preventing ..
  51. ncbi Assessment of platelet transfusion for reversal of aspirin after traumatic brain injury
    Arshad M Bachelani
    Division of General Surgery and Trauma, Department of Surgery, Mercy and Presbyterian Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Surgery 150:836-43. 2011
    b>Platelet transfusion is utilized increasingly for traumatic brain injury (TBI) for the reversal of aspirin (ASA) therapy...
  52. ncbi Early platelet transfusion improves platelet activity and may improve outcomes after intracerebral hemorrhage
    Andrew M Naidech
    Department of Neurology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611, USA
    Neurocrit Care 16:82-7. 2012
    ..We tested the hypotheses that platelet transfusion improves measured platelet activity...
  53. ncbi Platelet transfusion: an unnecessary risk for mild traumatic brain injury patients on antiplatelet therapy
    Chad W Washington
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Trauma 71:358-63. 2011
    To determine whether there is a benefit to platelet transfusion in mild traumatic brain injury (MTBI) patients with intracranial hemorrhage (ICH), taking antiplatelet therapy before hospitalization.
  54. ncbi Immature platelet fraction measurement: a future guide to platelet transfusion requirement after haematopoietic stem cell transplantation
    C Briggs
    Department of Haematology, University College London Hospital, London, UK
    Transfus Med 16:101-9. 2006
    ..The ability to predict when platelet recovery will occur should allow a more reasoned approach to platelet transfusion. An increase in reticulated platelets demonstrates impending platelet recovery...
  55. ncbi Coronary stent occlusion after platelet transfusion: a case series
    Alexander D Cornet
    Department of Intensive Care, V U Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Invasive Cardiol 19:E297-9. 2007
    ..patients with gastrointestinal bleeding or who were scheduled for emergency surgery and who received donor platelet transfusion early in the course after stenting...
  56. pmc PATCH: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trial
    Koen de Gans
    Department of Neurology, Academic Medical Centre, H2 222, PO Box 22660 1100 DD Amsterdam, The Netherlands
    BMC Neurol 10:19. 2010
    ..Because intracerebral haemorrhage patients who are on antiplatelet therapy have been shown to be particularly at risk of early haematoma growth, platelet transfusion may have a beneficial effect.
  57. ncbi A prospective randomized trial of prophylactic platelet transfusion and bleeding incidence in hematopoietic stem cell transplant recipients: 10,000/L versus 20,000/microL trigger
    Marc S Zumberg
    University of Florida College of Medicine, Department of Medicine, Gainesville 32610, USA
    Biol Blood Marrow Transplant 8:569-76. 2002
    An optimal platelet-count threshold for prophylactic platelet transfusion in hematopoietic stem cell transplant (HSCT) recipients has yet to be determined...
  58. ncbi Lowering the prophylactic platelet transfusion threshold: a prospective analysis
    J B Lawrence
    Institute of Pathology; Reserve University and University Hospitals of Cleveland, OH 44106, USA
    Leuk Lymphoma 41:67-76. 2001
    The 20 x 10(9) /L threshold for prophylactic platelet transfusion may be unnecessarily high. Few prospective studies, however, in which other trigger values were tested have been published...
  59. ncbi Past and future approaches to assess the quality of platelets for transfusion
    Elisabeth Maurer-Spurej
    Canadian Blood Services, Vancouver, BC, Canada
    Transfus Med Rev 21:295-306. 2007
    ..Recently, a new test for platelet quality has been introduced that uses dynamic light scattering. The advantages and remaining challenges for dynamic light scattering before it can become a routine platelet quality test are discussed...
  60. ncbi The clinical impact of platelet refractoriness: correlation with bleeding and survival
    Jean Louis H Kerkhoffs
    Sanquin Blood Bank, South West Region, Leiden, The Netherlands
    Transfusion 48:1959-65. 2008
    ..The clinical impact of PLT transfusion failure was investigated in 117 patients, part of a randomized PLT transfusion trial, which excluded patients with HLA and/or HPA alloantibodies...
  61. ncbi A systematic assessment of the quality of reporting for platelet transfusion studies
    Meghan Delaney
    Puget Sound Blood Center, Seattle, Washington 98104, USA
    Transfusion 50:2135-44. 2010
    ..A recent review of clinical platelet (PLT) studies indicated variability in reporting. We undertook a critical analysis of PLT transfusion studies to determine the quality of reporting...
  62. ncbi Patient and product factors affecting platelet transfusion results
    Dominik Heim
    Hematology, University Hospital, Basel, Switzerland
    Transfusion 48:681-7. 2008
    ..Optimizing PLT transfusions is in the interest of not only patient safety but also economic importance. Only few studies have evaluated factors associated with transfusion results...
  63. pmc Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients
    Sherrill J Slichter
    Puget Sound Blood Center, Seattle, WA 98104 1256, USA
    Blood 105:4106-14. 2005
    ..The only factors that reduced platelet refractoriness rates were increasing the dose of platelets transfused or transfusing filtered apheresis platelets...
  64. ncbi Evaluation of platelet transfusion triggers in a tertiary-care hospital
    Bruce Cameron
    Division of Hematology and Transfusion Medicine, Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada
    Transfusion 47:206-11. 2007
    ..An analysis of patterns of utilization has been undertaken to evaluate practice...
  65. ncbi Acute bleeding complications in patients after hematopoietic stem cell transplantation with prophylactic platelet transfusion triggers of 10 x 10(9) and 20 x 10(9) per L
    Shoshan Nevo
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Bunting Blaustein Cancer Research Building, Baltimore, Maryland, USA
    Transfusion 47:801-12. 2007
    ..This retrospective analysis evaluates utilization of blood transfusions, risk of bleeding, and survival in 480 HSCT patients at 10 x 10(9) and 20 x 10(9) per L prophylactic trigger levels...
  66. ncbi Lack of efficacy of prophylactic platelet transfusion for severe thrombocytopenia in adults with acute uncomplicated dengue infection
    David C Lye
    Department of Infectious Disease, Tan Tock Seng Hospital, National Healthcare Group, Singapore
    Clin Infect Dis 48:1262-5. 2009
    ..thrombocytopenia (platelet count, < 20 x 10(3) platelets/microL) without prior bleeding, 188 were given platelet transfusion. Subsequent bleeding, platelet increment, and platelet recovery were similar between patients given ..
  67. ncbi Platelet alloimmunization in multitransfused patients with haemato-oncological disorders
    Meenu Bajpai
    Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Natl Med J India 18:134-6. 2005
    ..We also assessed the effect of alloimmunization on response to platelet transfusion.
  68. ncbi Advances and controversies in neonatal ICU platelet transfusion practice
    Robert D Christensen
    Intermountain Healthcare, 36 S State Street, Salt Lake City, UT, USA
    Adv Pediatr 55:255-69. 2008
    ..A renewed interest in platelet transfusion studies is needed, if essential data is to be gathered to improve NICU platelet transfusion practice...
  69. ncbi Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 47:593-8. 2007
    ..It was considered that early substitution with PLTs and fresh-frozen plasma (FFP) would prevent development of coagulopathy and thus improve survival...
  70. ncbi Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    John B Holcomb
    United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Ann Surg 248:447-58. 2008
    ....
  71. ncbi Platelet transfusion and postoperative infection in cardiac surgery
    Eleftherios C Vamvakas
    Transfusion 47:352-4; author reply 354-6. 2007
  72. ncbi Platelet transfusion refractoriness
    Eldad Hod
    Columbia University Medical Center New York Presbyterian Hospital, New York, NY, USA
    Br J Haematol 142:348-60. 2008
    ..This review will discuss the aetiology, diagnosis, and management of refractoriness to platelet transfusion, a complicated problem for both the treating physicians and the transfusion services supporting these ..
  73. ncbi Slow infusion of platelets: a possible alternative in the management of refractory thrombocytopenic patients
    Aida Narvios
    Am J Hematol 79:80. 2005
  74. ncbi Thrombocytopenia in the neonate
    Irene Roberts
    Paediatric Haematology, Imperial College, London, UK
    Blood Rev 22:173-86. 2008
    ..b>Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients...
  75. ncbi Platelet storage lesion: an update on the impact of various leukoreduction processes on the biological response modifiers
    Jerard Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 34:125-30. 2006
    ....
  76. ncbi Thrombocytopenia related neonatal outcome in preterms
    Lea Bonifacio
    Department of Pediatrics, Division of Neonatal Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Indian J Pediatr 74:269-74. 2007
    To investigate the thrombocytopenia and platelet transfusion related outcome in very preterm infants.
  77. ncbi New paradigms in the management of alloimmune refractoriness to platelet transfusions
    Ralph R Vassallo
    University of Pennsylvania School of Medicine and American Red Cross Blood Services Heritage Division, Penn Jersey Region, Philadelphia, Pennsylvania 19123, USA
    Curr Opin Hematol 14:655-63. 2007
    ..Some will exhibit platelet transfusion refractoriness, defined as inappropriately low platelet count increments after two or more consecutive ..
  78. ncbi Neonatal thrombocytopenia: what we do and don't know
    Martha Sola-Visner
    Drexel University College of Medicine, and St Christopher s Hospital for Children, Drexel University Neonatology Research at MCP, Philadelphia, PA 19129, United States
    Early Hum Dev 84:499-506. 2008
    ..The existing evidence to establish platelet transfusion triggers in neonates is very limited, but it suggests that transfusing platelets to non-bleeding neonates ..
  79. ncbi Buffy-coat-derived pooled platelet concentrates and apheresis platelet concentrates: which product type should be preferred?
    H Schrezenmeier
    Red Cross Blood Service Baden Württemberg Hessen, Germany
    Vox Sang 99:1-15. 2010
    ....
  80. ncbi Mechanisms underlying thrombocytopenia in the neonatal intensive care unit
    M C Sola
    Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Acta Paediatr Suppl 91:66-73. 2002
    ..This review focuses on both traditional and innovative methods used to evaluate the mechanisms responsible for thrombocytopenia in neonates, and analyzes the data generated from those methods...
  81. ncbi ABO-identical versus nonidentical platelet transfusion: a systematic review
    Nadine Shehata
    Department of Medicine, University of Toronto, Division of Hematology, St Michael s Hospital, Toronto, Ontario, Canada
    Transfusion 49:2442-53. 2009
    ..The primary objective of this report is to assess whether ABO-identical PLT transfusion is associated with improved mortality and/or morbidity for patients with hematologic/oncologic disorders...
  82. ncbi [Platelet alloimmunization in patients with oncologic blood disorders treated with multiple transfusions: prospective study in adults and children]
    J Pereira
    Departamento de Hematología Oncología, Escuela de Medicina P Universidad Católica de Chile, Santiago
    Rev Med Chil 125:1305-12. 1997
    Refractoriness continues to be a major complication of platelet transfusion therapy in patients with multiple transfusions. Despite most cases are secondary to non-immune causes, the most serious is that associated to alloimmunization...
  83. pmc Dose of prophylactic platelet transfusions and prevention of hemorrhage
    Sherrill J Slichter
    Puget Sound Blood Center, Seattle, WA 98104 1256, USA
    N Engl J Med 362:600-13. 2010
    ..We conducted a trial of prophylactic platelet transfusions to evaluate the effect of platelet dose on bleeding in patients with hypoproliferative thrombocytopenia...
  84. ncbi A risk model for thrombocytopenia requiring platelet transfusion after cytotoxic chemotherapy
    J Y Blay
    Centre L BERARD, Lyon, France
    Blood 92:405-10. 1998
    ..1) from those calculated in the model. This risk index could be useful to identify patients at high risk for chemotherapy-induced thrombocytopenia requiring platelet transfusions...
  85. ncbi Platelet transfusions in the neonatal intensive care unit:factors predicting which patients will require multiple transfusions
    A Del Vecchio
    Division of Neonatology, Department of Pediatrics, University of Florida, College of Medicine, Gainesville, Florida, USA
    Transfusion 41:803-8. 2001
    ..However, two clinical conditions did; liver disease and renal insufficiency. Neonates who received one platelet transfusion had a relative risk of death 10.4 times that in neonates who received none (p = 0.0001)...
  86. ncbi Platelet rich plasma: biology and new technology
    William S Pietrzak
    Biomet, Inc, Warsaw, IN 46580 0587, USA
    J Craniofac Surg 16:1043-54. 2005
    ....
  87. ncbi Evaluation and treatment of severe and prolonged thrombocytopenia in neonates
    Martha C Sola
    Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Clin Perinatol 31:1-14. 2004
    ..As a consequence of these deficiencies in knowledge, there is great variability in platelet transfusion practices among NICUs...
  88. ncbi Impact of platelet transfusion on hematoma expansion in patients receiving antiplatelet agents before intracerebral hemorrhage
    Andrew F Ducruet
    Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
    Neurol Res 32:706-10. 2010
    ..We sought to determine the clinical efficacy of platelet transfusion and its impact on systemic complications following ICH in a cohort of patients receiving antiplatelet ..
  89. ncbi Neonatal thrombocytopenia
    Irene Roberts
    Department of Haematology, Imperial College London and Imperial Healthcare NHS Trust, London, UK
    Semin Fetal Neonatal Med 13:256-64. 2008
    ..b>Platelet transfusion is the mainstay of treatment for severe thrombocytopenia...
  90. ncbi Evaluation of platelet transfusion thresholds in patients with acute myeloblastic leukemia receiving induction chemotherapy
    Satoko Oka
    Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke
    Intern Med 46:1669-70. 2007
  91. ncbi Platelet-reactive HLA antibodies associated with low posttransfusion platelet increments:a comparison between the monoclonal antibody-specific immobilization of platelet antigens assay and the lymphocytotoxicity test
    M Kurz
    Clinic for Blood Group Serology and Transfusion Medicine, Division of Hematology and Bone Marrow Transplantation Unit, Department of Medicine 1, University of Vienna, Vienna, Austria
    Transfusion 41:771-4. 2001
    ..17%). CONCLUSION: The MAIPA assay is more sensitive than the standard LCT in detecting platelet-reactive HLA antibodies. These MAIPA-positive/LCT-negative HLA antibodies affect the posttransfusion platelet increment...
  92. ncbi Severe Thrombocytopenia in the NICU
    Vickie L Baer
    Department of Women and Newborns, Intermountain Healthcare, Salt Lake City, Utah 84403, USA
    Pediatrics 124:e1095-100. 2009
    ..Severe thrombocytopenia (platelets <or= 50000/microL) in a NICU patient can have significant consequences; however, previous reports have not focused exclusively on NICU patients with counts this low...
  93. ncbi Prospective, observational study of outcomes in neonates with severe thrombocytopenia
    Simon J Stanworth
    National Blood Service, Level 2, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, England
    Pediatrics 124:e826-34. 2009
    ..A cross-sectional, observational study of outcomes for neonates with severe neonatal thrombocytopenia (SNT; platelet count of <60 x 10(9) platelets per L) was performed to examine hemorrhage and use of platelet transfusions...
  94. ncbi Fresh frozen plasma and platelet transfusion for nonbleeding patients in the intensive care unit: benefit or harm?
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care Med 34:S170-3. 2006
    ..We searched the National Library of Medicine PubMed database as well as references of retrieved articles and summarized the current evidence for the use of FFP and platelet transfusions in critically ill patients...
  95. ncbi The impact of platelet transfusion in massively transfused trauma patients
    Kenji Inaba
    University of Southern California Keck School of Medicine, Division of Trauma, Emergency Surgery and Surgical Critical Care, Los Angeles County and University of Southern California Medical Center, Los Angeles, CA 90033 4525, USA
    J Am Coll Surg 211:573-9. 2010
    The impact of platelet transfusion in trauma patients undergoing a massive transfusion (MT) was evaluated.
  96. ncbi Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients (CME)
    Jeremy G Perkins
    Walter Reed Army Medical Center, Washington, DC 20307, USA
    Transfusion 51:242-52. 2011
    ..In massively transfused trauma patients, we compared outcomes of patients receiving FWB to those receiving aPLT...
  97. ncbi Platelet transfusion therapy
    Sherrill J Slichter
    Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104 1256, USA
    Hematol Oncol Clin North Am 21:697-729, vii. 2007
    ..Identification, prevention, and management of adverse consequences of platelet transfusions and platelet refractoriness are discussed...
  98. ncbi Presentation and pattern of symptoms in 382 patients with Glanzmann thrombasthenia in Iran
    G Toogeh
    Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Am J Hematol 77:198-9. 2004
    ..As expected, almost all the patients had a normal platelet count while the leukocyte count was increased in 19.3%. Among women, an unexpected low rate of pregnancies was observed...
  99. ncbi Earlier detection of HLA alloimmunization in platelet transfusion refractoriness by flow cytometric analysis
    Shinichiro Sato
    Transfusion 45:1399-401. 2005
  100. ncbi Platelet transfusions
    David F Stroncek
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1184, USA
    Lancet 370:427-38. 2007
    ..5 million platelet products are transfused in the USA each year, 2.9 million products in Europe. However, platelet transfusion can transmit infections and trigger serious immune reactions and they can be rendered ineffective by ..
  101. ncbi Gamma irradiation does not affect 7-day storage of platelet concentrates
    P F van der Meer
    Sanquin Blood Bank North West Region, Amsterdam, The Netherlands
    Vox Sang 89:97-9. 2005
    ..Extension of storage of leucocyte-reduced platelet concentrates (LR-PCs) to 7 days has recently been introduced, but the effect of gamma irradiation on in vitro parameters was unknown...

Research Grants62

  1. REVERSIBLE PATHOLOGY OF THE PLATELET STORAGE LESION
    Brian Smith; Fiscal Year: 2001
    ..The long term goal of the project, which combines the synergistic expertise of several established investigators, is to improve the clinical results of platelet transfusion.
  2. The Development of a Refrigerated Platelet Product
    HANS WANDALL; Fiscal Year: 2007
    ..diminution of bacterial contamination, and increased ability to provide platelets of improved functional quality to patients needing platelet transfusion. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]
  3. Platelet Transfusion Induced Transplant Rejection Across mHA barriers.
    James C Zimring; Fiscal Year: 2013
    ..mechanistic understanding of the immunization and subsequent transplant rejection that are caused by platelet transfusion. We propose to study the mechanisms of platelet transfusion induced BMT rejection through the following ..
  4. Role of AhR During Megakaryopoiesis
    STEPHAN CADET LINDSEY; Fiscal Year: 2011
    ..Most MDS patients have chronic thrombocytopenia, but platelet transfusion is complicated by the development of allogeneic antibodies and ca. 30% of MDS patients die of bleeding...
  5. Bioengineering challenges for platelet production from hematopoietic stem cells
    William M Miller; Fiscal Year: 2010
    ..Platelet collection typically requires pooling harvests from multiple donors. Platelet transfusion risks from bacterial contamination, blood-borne pathogens, and alloimmunization are compounded because ..
  6. Transfusion Medicine/Hemostasis Core Clinical Center
    Thomas L Ortel; Fiscal Year: 2012
    ..The TMH Network currently has clinical trials recruiting patients to determine the optimal platelet transfusion dose and define the role of fresh frozen plasma in patients with prolonged clotting times undergoing liver ..
  7. Statistical Methodology Development in Blood Transfusion Protocol Research
    Mohammad H Rahbar; Fiscal Year: 2013
    ..2) to develop a multi-type recurrent event model for estimating time-dependent RBC, plasma, and platelet transfusion rates, and evaluating their impact on patient survival...
  8. Transfusion Medicine/Hemostasis Clinical Trials Network
    Ellis J Neufeld; Fiscal Year: 2011
    ..To date, the network has launched three active clinical studies, one on optimal platelet transfusion dose in thrombocytopenia, one on treatment of long INR to prevent surgical bleeding, and one on treatment ..
  9. Monitoring Physiological Stress: A Novel Biophysical Approach for the Rapid Detec
    RONALD J RIEDER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Platelet transfusion is the leading cause of transfusion related bacterial sepsis...
  10. PHOTOCHEMICAL DECONTAMINATION OF PLATELET CONCENTRATES
    Laurence Corash; Fiscal Year: 1993
    Therapeutic platelet transfusion is currently estimated at 5-7 million units annually, and is expected to increase with expanded use of organ transplantation and intensive cancer chemotherapy...
  11. NEW APPROACH TO THE REGULATION OF HUMAN T CELL FUNCTION
    William Osborne; Fiscal Year: 1990
    ..a novel approach to the specific regulation of T cell function; the results may be directly applicable to platelet transfusion therapy in the support of cancer patients, and may benefit organ and marrow transplantation and treatment ..
  12. TRANSFUSION MEDICINE/HEMOSTASIS TRAIL SITE AT PSBC
    Sherrill J Slichter; Fiscal Year: 2012
    ..Principal Investigator to develop the trial to evaluate epsilon-amino-caprioc acid (EACA) as an adjuvent to platelet transfusion therapy. (Renewal application proposed protocol #2). Dr...
  13. Non-donor-Dependent Production of Wildtype and Modified Platelets
    Mortimer Poncz; Fiscal Year: 2009
    ..for targeted delivery of this fibrinolytic agent using a modification of the above NOD/SCID mouse platelet transfusion model for efficacy of the uPA-containing platelets to lyse thrombi in a targeted fashion...
  14. Genomic dissection of platelet production
    Warren Alexander; Fiscal Year: 2009
    ..b>Platelet transfusion is the only current effective treatment for severe thrombocytopenia...
  15. EFFECT OF AN EXPERT SYSTEM ON PLATELET TRANSFUSION
    DONALD CONNELLY; Fiscal Year: 1992
    ..The first specific aim is to implement a knowledge-based system for the evaluation of requests for platelet transfusion. An existing expert system that reflects current scientific knowledge as well as the clinical heuristics ..
  16. HLAMatchmaker for Transplantation and Transfusion
    Rene Duquesnoy; Fiscal Year: 2007
    ..the relative immunogenicity of triplet-defined epitopes, (3) Assess clinical relevance of HLAMatchmaker in platelet transfusion support of refractory thrombocytopenic patients and stem cell transplantation from unrelated donors, (4) ..
  17. MEGAKARYOCYTE EXPANSION FROM MOBILIZED PERIPHERAL BLOOD
    Alan Smith; Fiscal Year: 1999
    ..The most effective therapy for post-transplant thrombocytopenia is platelet transfusion. The use of high dose chemotherapy has greatly increased the demand for platelet products...
  18. BIOCHEMICAL RELATIONSHIP OF PLATELET AND PLASMA HLA
    K Kao; Fiscal Year: 1993
    ..Finding compatible platelets for those patients is a major obstacle in platelet transfusion therapy...
  19. IMMUNE MEDIATED REFRACTORINESS TO PLATELET TRANSFUSION
    Douglas Christie; Fiscal Year: 1992
    ..identification and characterization of platelet antigens and antibodies in patients refractory to platelet transfusion will be investigated using several immunologic assays, including immunofluorescence, lymphocytotoxicity, ..
  20. Rapid Detection of Bacterial Contamination in Platelets
    XING XIANG LI; Fiscal Year: 2004
    ..Bacterial infection due to platelet transfusion can be minimized with the use of an effective bacterial detection test that is rapid, specific, inexpensive ..
  21. TRANSFUSION TRIAL TO PREVENT PLATELET ALLOIMMUNIZATIONS
    Wendell Rosse; Fiscal Year: 1992
    Alloimmunization to antigens on platelets is one of the most severe limiting factors in platelet transfusion. In this application to become a member of a cooperative trial for the prevention of alloimmunization, we propose two strategies ..
  22. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  23. Proteomics and Biomarkers for Hepatocellular Cancer
    Nezam Afdhal; Fiscal Year: 2004
    ..These studies may lead to identification of more specific and sensitive biomarkers for HCC in HCV which can then be validated further in prospective clinical trials. ..
  24. PROTEIN LIPID INTERACTIONS IN GALLSTONE PATHOGENESIS
    Nezam Afdhal; Fiscal Year: 2002
    ..These studies may lead to strategies for the prevention and non-surgical therapy of this very common disease. ..
  25. Antiviral Therapy in African Americans with HCV
    Nezam Afdhal; Fiscal Year: 2005
    ..Specimens of liver tissue and serum will be collected for basic studies on viral resistance. These studies should help determine the best therapy for AA with HCV. ..
  26. RESEARCH TRAINING IN TRANSFUSION MEDICINE
    Jeffrey McCullough; Fiscal Year: 2003
    ..abstract_text> ..
  27. ENGRAFTING SENSITIZED HOSTS WITH NONABLATIVE REGIMENS
    Richard Nash; Fiscal Year: 2002
    ..By lessening the morbidity and mortality associated with conventional conditioning, these studies could significantly change the management of selected inherited red blood cell diseases. ..
  28. WT1 Expression in Patients with MDS Treated with ATG an*
    H Deeg; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  29. PROGENITORS FOR ERYTHROCYTIC & MEGAKARYOCYTIC LINEAGES
    WILLIAM SLAYTON; Fiscal Year: 2003
    ..Slayton's research progress. In this rich and supportive environment, Dr. Slayton will gain the experience necessary to contribute to the understanding of the early cellular and molecular events in megakaryopoiesis. ..
  30. Proteasome Inhibition in Myelodysplastic Syndromes
    Jane Liesveld; Fiscal Year: 2006
    ..These studies will define a potential therapeutic role for bortezomib in MDS and will aid in understanding the hematopoietic stem cell in these disorders. ..
  31. Protection from GVHD with Gene-Modified Donor T Cells
    Richard Nash; Fiscal Year: 2008
    ....
  32. Enhanced Primary Repair of Ligament Injuries
    Martha Murray; Fiscal Year: 2008
    ..In the third aim, the optimized scaffolds will be tested in an in vivo canine ACL non-union model. Information gained in each of these aims will serve to improve our understanding of mechanisms of ligament healing. ..
  33. Lung Transplantation and Immune Tolerance in Young Recipients
    Richard Nash; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. Farnesyltransferase Inhibitor Therapy for Myelodysplasia
    Razelle Kurzrock; Fiscal Year: 2002
    ....
  35. Improving Transfusion Practices Using Decision Support
    Jeffrey Rothschild; Fiscal Year: 2004
    ..We will also examine whether improvements in appropriate transfusion ordering behavior among clinicians using decision support tools will be greater than improvements achieved by educational programs alone. ..
  36. COST EFFECTIVENESS OF GENETIC SCREENING FOR COLON CANCER
    Scott Ramsey; Fiscal Year: 2002
    ....
  37. Cell Death and Clonal Survival in Myelodysplastic Syndr*
    H Deeg; Fiscal Year: 2008
    ..To achieve these objectives, we must better understand the underlying mechanisms of MDS and thereby identify ways by which the disease process can be arrested, progression prevented, and the disease hopefully be cured. ..
  38. INTEGRIN SIGNALING IN ACUTE LYMPHOBLASTIC LEUKEMIA
    Arnold Freedman; Fiscal Year: 2001
    ..Understanding the cell-cell interaction between BM stromal cells and pre-B ALL cells may provide future therapeutic strategies with which to modulate the growth of these leukemias. ..
  39. A Genetic Screening Policy Model for Colorectal Cancer
    Scott Ramsey; Fiscal Year: 2006
    ..The model will incorporate QOL information from Aim 2, along with family history, clinical, and screening information from the Seattle CFR. ..
  40. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  41. Aminocaproic Acid and Bleeding in Spinal Surgery
    Sean Berenholtz; Fiscal Year: 2006
    ..These projects and the career development plan described will build a foundation for a successful career as an independent investigator. ..
  42. Nonablative AlloSCT in Refractory Autoimmune Disease
    Mitchell Cairo; Fiscal Year: 2003
    ....
  43. Inducing Immune Tolerance with Receptor Modified T Cells
    Terrence Geiger; Fiscal Year: 2003
    ..Together this information will provide a starting point for the application of GM-TCs to human immunologic conditions. ..
  44. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  45. Patient-Oriented Cancer Research Training Program
    Emil Freireich; Fiscal Year: 2004
    ..The program will prepare oncology physician specialists for careers in academic patient-oriented research in oncology. ..
  46. Conference-Safeguarding Adult/Pediatric Stem Cell Donors
    Edward Snyder; Fiscal Year: 2004
    ..This Symposium would address the need for such Standards and stimulate the process. AIM 3 will be to publish a summary of the Symposium in a nationally recognized Journal. ..
  47. THE ROLE OF PL3K IN THROMBOPOIETIN SIGNALING
    Amy Geddis; Fiscal Year: 2005
    ..A defined plan of training is presented in which the applicant will develop the experience and skills necessary for success as an independent investigator in Hematology. ..
  48. CpG Plus Rituximab Therapy in Follicular Lymphoma
    Arnold Freedman; Fiscal Year: 2005
    ..This study is a novel approach to treating FL, where augmenting antigen presentation and effector cells may lead to enhanced cytotoxic effects of rituximab and induce anti-tumor immunity. ..
  49. Curcumin/Bioperine in Multiple Myeloma
    Saroj Vadhan Raj; Fiscal Year: 2005
    ..Knowledge gained from these studies may provide useful information on how best to use these natural products in the treatment of cancer. ..
  50. NOVEL THERAPEUTIC STRATEGIES IN MYELODYSPLASTIC SYNDROME
    H Deeg; Fiscal Year: 2003
    ..Optimization of therapy, in turn, should reduce morbidity and mortality associated with MDS and improve the quality of life of patients with MDS. ..
  51. Race & Viral Resistance in Chronic Hepatitis C (VIRAHEP*
    Robert Brown; Fiscal Year: 2005
    ..abstract_text> ..
  52. 5-Azacytidine and MS-275 in Myeloid Malignancies
    Steven Gore; Fiscal Year: 2005
    ..abstract_text> ..
  53. Exploratory Trial of Curcumin in Pancreatic Cancer
    Razelle Kurzrock; Fiscal Year: 2005
    ..These studies should provide the foundation for the development of curcumin as an anticancer agent and may lead to a novel approach to the management of pancreatic cancer. ..
  54. Symposium on Emerging Cardiac Cellular Therapies
    Edward Snyder; Fiscal Year: 2005
    ..abstract_text> ..
  55. Clinical Research Training Institute
    James George; Fiscal Year: 2005
    ..It is through this near one to one ratio with the trainees that ASH intends to foster and sustain interest in clinical hematologic research and thereby help stimulate the career development of future clinical researchers in hematology. ..
  56. Rare Antigens in Neonatal Alloimmune Thrombocytopenia
    Julie Peterson; Fiscal Year: 2006
    ..4. Generate soluble recombinant platelet glycoproteins carrying "rare" platelet alloantigens to provide a tool for rapid detection and identification of antibodies in mothers who are immunized against these antigens ..
  57. Nonmyeloablative Hematopoietic Cell Transplantation for Severe Systemic Sclerosis
    Richard Nash; Fiscal Year: 2006
    ..The unique observations in this study regarding responses and recovery of organs after inducing a sustained remission of SSc will serve to focus and direct other non-transplant research activities. [unreadable] [unreadable] [unreadable]..
  58. Etanercept Therapy in Follicular Lymphoma
    Arnold Freedman; Fiscal Year: 2003
    ..This study is a novel approach to treating FL, where targeting the microenvironment of the tumor may inhibit the growth and survival of the neoplastic cells. ..