erythrocyte transfusion

Summary

Summary: The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.

Top Publications

  1. ncbi Clinical consequences of red cell storage in the critically ill
    Alan Tinmouth
    Center for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 46:2014-27. 2006
  2. ncbi The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
  3. ncbi Clinical practice guideline: red blood cell transfusion in adult trauma and critical care
    Lena M Napolitano
    Crit Care Med 37:3124-57. 2009
  4. ncbi Red blood cell transfusion practice in patients presenting with acute upper gastrointestinal bleeding: a survey of 815 UK clinicians
    Vipul Jairath
    NHS Blood and Transplant and Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
    Transfusion 51:1940-8. 2011
  5. ncbi Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials
    Julia Bohlius
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Lancet 373:1532-42. 2009
  6. ncbi Definitions of the phenotypic manifestations of sickle cell disease
    Samir K Ballas
    Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
    Am J Hematol 85:6-13. 2010
  7. ncbi Umbilical cord milking reduces the need for red cell transfusions and improves neonatal adaptation in infants born at less than 29 weeks' gestation: a randomised controlled trial
    S Hosono
    Dr S Hosono, Department of Paediatrics and Child Health, Nihon University School of Medicine, 30 1 Oyaguchi Itabashi, Tokyo 173 8610, Japan
    Arch Dis Child Fetal Neonatal Ed 93:F14-9. 2008
  8. pmc Age of red blood cells and mortality in the critically ill
    Ville Pettila
    Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Commercial Road, Melbourne 3004, Victoria, Australia
    Crit Care 15:R116. 2011
  9. ncbi Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients
    Leo van de Watering
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 46:1712-8. 2006
  10. ncbi Effect of duration of red blood cell storage on early and late mortality after coronary artery bypass grafting
    Albert H M van Straten
    Department of Cardio Thoracic Surgery, Catharina Hospital, Eindhoven, The Netherlands
    J Thorac Cardiovasc Surg 141:231-7. 2011

Detail Information

Publications275 found, 100 shown here

  1. ncbi Clinical consequences of red cell storage in the critically ill
    Alan Tinmouth
    Center for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 46:2014-27. 2006
    ..These data suggest a possible detrimental clinical effect associated with the transfusion of stored RBCs; randomized clinical trials further evaluating the clinical consequences of transfusing older stored RBCs are required...
  2. ncbi The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
    ..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
  3. ncbi Clinical practice guideline: red blood cell transfusion in adult trauma and critical care
    Lena M Napolitano
    Crit Care Med 37:3124-57. 2009
    ..To develop a clinical practice guideline for red blood cell transfusion in adult trauma and critical care...
  4. ncbi Red blood cell transfusion practice in patients presenting with acute upper gastrointestinal bleeding: a survey of 815 UK clinicians
    Vipul Jairath
    NHS Blood and Transplant and Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
    Transfusion 51:1940-8. 2011
    ..We aimed to survey UK clinicians about their RBC transfusion practice in AUGIB...
  5. ncbi Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials
    Julia Bohlius
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Lancet 373:1532-42. 2009
    ..We therefore did a meta-analysis of randomised controlled trials in which these drugs plus red blood cell transfusions were compared with transfusion alone for prophylaxis or treatment of anaemia in patients with cancer...
  6. ncbi Definitions of the phenotypic manifestations of sickle cell disease
    Samir K Ballas
    Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
    Am J Hematol 85:6-13. 2010
    ....
  7. ncbi Umbilical cord milking reduces the need for red cell transfusions and improves neonatal adaptation in infants born at less than 29 weeks' gestation: a randomised controlled trial
    S Hosono
    Dr S Hosono, Department of Paediatrics and Child Health, Nihon University School of Medicine, 30 1 Oyaguchi Itabashi, Tokyo 173 8610, Japan
    Arch Dis Child Fetal Neonatal Ed 93:F14-9. 2008
    ..To investigate the effects of umbilical cord milking on the need for red blood cell (RBC) transfusion and morbidity in very preterm infants...
  8. pmc Age of red blood cells and mortality in the critically ill
    Ville Pettila
    Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Commercial Road, Melbourne 3004, Victoria, Australia
    Crit Care 15:R116. 2011
    ..We hypothesized that exposure to even a single unit of older RBCs may be associated with an increased risk of death...
  9. ncbi Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients
    Leo van de Watering
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 46:1712-8. 2006
    ..The aim in this study was to investigate the possible role of the storage time of RBC transfusions on the outcome of coronary artery bypass graft (CABG) surgery patients...
  10. ncbi Effect of duration of red blood cell storage on early and late mortality after coronary artery bypass grafting
    Albert H M van Straten
    Department of Cardio Thoracic Surgery, Catharina Hospital, Eindhoven, The Netherlands
    J Thorac Cardiovasc Surg 141:231-7. 2011
    ..We tested the hypothesis that longer storage of transfused red blood cells increases the risk of early and late mortality in patients who undergo coronary artery bypass grafting...
  11. pmc Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitor
    John A Widness
    Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Pediatrics 115:1299-306. 2005
    ..To date, researchers have had only limited success in finding ways to reduce transfusions significantly in this patient population...
  12. ncbi Red blood cell transfusion is associated with increased rebleeding in patients with nonvariceal upper gastrointestinal bleeding
    S Restellini
    Department of Medical Specialities, Division of Gastroenterology and Hepatology, Geneva s University Hospitals and University of Geneva, Geneva, Switzerland
    Aliment Pharmacol Ther 37:316-22. 2013
    ..Studies in other critically ill cohorts suggest associations between transfusions and adverse patient outcomes...
  13. ncbi The effect of older blood on mortality, need for ICU care, and the length of ICU stay after major trauma
    Zuri Murrell
    Department of Surgery, Harbor UCLA Medical Center, 1000 W Carson St, Box 15, Torrance, CA 90509, USA
    Am Surg 71:781-5. 2005
    ..87-1.64). The quantity of aged blood is an independent risk factor for length of ICU care. This may be a proxy indicator for multiple organ failure. Further research is required to define which patients may benefit from newer blood...
  14. ncbi Storage time of allogeneic red blood cells is associated with risk of severe postoperative infection after coronary artery bypass grafting
    Jan Jesper Andreasen
    Department of Cardiothoracic Surgery, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Eur J Cardiothorac Surg 39:329-34. 2011
    ..We therefore examined the association between the age of transfused RBCs and development of severe postoperative infection following coronary artery bypass grafting (CABG) in a large population-based cohort study...
  15. pmc Proof of principle for transfusion of in vitro-generated red blood cells
    Marie Catherine Giarratana
    UPMC Paris, UMR_S938 CDR Saint Antoine, Prolifération et Différenciation des Cellules Souches, France
    Blood 118:5071-9. 2011
    ..These data establish the proof of principle for transfusion of in vitro-generated RBCs and path the way toward new developments in transfusion medicine. This study is registered at http://www.clinicaltrials.gov as NCT0929266...
  16. ncbi A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q
    Pierre Fenaux
    Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris XIII, Bobigny, France
    Blood 118:3765-76. 2011
    ..Lenalidomide is beneficial and has an acceptable safety profile in transfusion-dependent patients with Low-/Intermediate-1-risk del5q myelodysplastic syndrome. This trial was registered at www.clinicaltrials.gov as #NCT00179621...
  17. ncbi Red blood cell transfusion in clinical practice
    Harvey G Klein
    Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    Lancet 370:415-26. 2007
    ..Despite serious immunological and non-immunological complications, RBC transfusion holds a therapeutic index that exceeds that of many common medications...
  18. ncbi Transfusion-related immunomodulation (TRIM): an update
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, University of Ottawa, Faculty of Medicine, Canada
    Blood Rev 21:327-48. 2007
    ....
  19. ncbi Activity-based costs of blood transfusions in surgical patients at four hospitals
    Aryeh Shander
    The Institute for Patient Blood Management and Bloodless Medicine at Englewood Hospital and Medical Center, Englewood, New Jersey, USA
    Transfusion 50:753-65. 2010
    ..Determining the cost of supplying patients with blood transfusions requires an in-depth examination of the complex array of activities surrounding the decision to transfuse...
  20. ncbi Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60 years?
    Juan C Duchesne
    Division of Trauma Critical Care Surgery, Department of Surgery, Tulane University School of Medicine New Orleans, Louisiana 70112 2699, USA
    J Trauma 65:272-6; discussion 276-8. 2008
    ..We hypothesize a similar improvement in mortality in civilian trauma patients that require massive transfusion and are treated with a FFP to PRBC ratio closer to 1:1...
  21. ncbi Blood use in elective surgery: the Austrian benchmark study
    Hans Gombotz
    Department of Anesthesiology and Intensive Care, General Hospital Linz, Krankenhausstrasse 9, A 4020 Linz, Austria
    Transfusion 47:1468-80. 2007
    ..The goal of this study was to measure and to compare the current transfusion practice and to identify predictors of transfusion in public hospitals to develop strategies to optimize transfusion practices...
  22. ncbi A survey of the demographics of blood use
    T J Cobain
    Department of Haematology and Genetics, South Eastern Area Laboratory Services, Sydney, Australia
    Transfus Med 17:1-15. 2007
    ..In Australia, red cell use of >or=50 units per episode was largely associated with multiple traumas. In Denmark, it was associated with gastrointestinal bleeding and various medical requests...
  23. ncbi A mathematical model of erythropoiesis in mice and rats. Part 4: Differences between bone marrow and spleen
    K Pantel
    Medizinische Universitatsklinik I, LFI EDV, Koln, F R G
    Cell Tissue Kinet 23:283-97. 1990
    ....
  24. ncbi Changing indications for red cell transfusion from 2000 to 2004 in the North of England
    J P Wallis
    Department of Haematology, Freeman Hospital, Newcastle upon Tyne, UK
    Transfus Med 16:411-7. 2006
    ..Promotion of good transfusion practice and alternatives to allogeneic transfusion should now focus on medical and surgical use of blood transfusion...
  25. ncbi Meta-analysis of clinical studies of the purported deleterious effects of "old" (versus "fresh") red blood cells: are we at equipoise?
    Eleftherios C Vamvakas
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Transfusion 50:600-10. 2010
    ..Such suspicion is required for intentionally exposing patients enrolled in randomized controlled trials (RCTs) to the known or probable--but rare--risks of old RBCs, to document (and prevent) purported common adverse effects of old RBCs...
  26. ncbi Red blood cell transfusions and nosocomial infections in critically ill patients
    Robert W Taylor
    St John s Mercy Medical Center, St Louis University, MO, USA
    Crit Care Med 34:2302-8; quiz 2309. 2006
    ....
  27. ncbi Reduction in red blood cell transfusions using a bedside analyzer in extremely low birth weight infants
    Ashima Madan
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    J Perinatol 25:21-5. 2005
    ....
  28. ncbi Red blood cell transfusion during septic shock in the ICU
    A Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 56:718-23. 2012
    ..Our aim was to evaluate RBC transfusion practice in septic shock in the intensive care unit (ICU), and patient characteristics and outcome associated with RBC transfusion...
  29. pmc Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study
    Christina Katsios
    Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
    Crit Care 15:R263. 2011
    ..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...
  30. ncbi Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome
    A W Bracey
    Department of Pathology, Texas Heart Institute St Luke s Episcopal Hospital and Prairie View A and M College of Nursing, Houston 77030, USA
    Transfusion 39:1070-7. 1999
    ..The goal of this study was to determine if lowering the hemoglobin threshold for red cell (RBC) transfusion to 8 g per dL after coronary artery bypass graft surgery would reduce blood use without adversely affecting patient outcome...
  31. ncbi Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14-year experience from a single center (CME)
    Michele Lasalle-Williams
    Bonfils Blood Center, Denver, CO 80230, USA
    Transfusion 51:1732-9. 2011
    ..Here, we report our experiences with extended RBC antigen matching for SCD patients...
  32. ncbi rs660 polymorphism in Ro52 (SSA1; TRIM21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease
    Zohreh Tatari-Calderone
    Center for Cancer and Immunology Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
    Mol Immunol 47:64-70. 2009
    ..These results suggest that rs660 polymorphism is a marker of efficiency of tolerance induction in early childhood and immune competence development to RBC antigens in SCD patients of pre-teen/teen age...
  33. ncbi Transfusion strategies for acute upper gastrointestinal bleeding
    Candid Villanueva
    Gastrointestinal Bleeding Unit, Department of Gastroenterology, Hospital de Sant Pau, Autonomous University, Barcelona, Spain
    N Engl J Med 368:11-21. 2013
    ..The hemoglobin threshold for transfusion of red cells in patients with acute gastrointestinal bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy...
  34. ncbi Red blood cell transfusion: a clinical practice guideline from the AABB*
    Jeffrey L Carson
    MD, Division of General Internal Medicine, UMDNJ Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08903, USA
    Ann Intern Med 157:49-58. 2012
    ....
  35. pmc Anaemia and its functional consequences in cancer patients: current challenges in management and prospects for improving therapy
    G D Demetri
    Center for Sarcoma and Bone Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Br J Cancer 84:31-7. 2001
    ..With this new option for therapy, further avenues of investigation should lead to renewed interest in the clinical benefits of optimal haemoglobin levels for patients with cancer...
  36. ncbi Effect of prophylactic transfusion of stored RBCs on oxygen reserve in response to acute isovolemic hemorrhage in a rodent model
    D Gray
    Department of Hematology, A.C. Burton Vascular Biology Laboratory, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario, Canada N6A 4G5
    Transfusion 41:950-6. 2001
    ..CONCLUSION: The physiologic impact of DPG depletion in transfused stored blood on oxygen availability in normal rats appears to be small and may be clinically inconsequential...
  37. ncbi Impact of transfusion of fresh-frozen plasma and packed red blood cells in a 1:1 ratio on survival of emergency department patients with severe trauma
    Shahriar Zehtabchi
    Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    Acad Emerg Med 16:371-8. 2009
    ..This evidence-based emergency medicine (EBM) review evaluates the evidence regarding the impact of 1:1 ratio of FFP:PRBC transfusion on survival of emergency department (ED) patients with severe trauma...
  38. ncbi Persistent effect of red cell transfusion on health-related quality of life after cardiac surgery
    Colleen Gorman Koch
    Department of Cardiothoracic Anesthesia, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Ann Thorac Surg 82:13-20. 2006
    ..Our objective was to investigate the relationship between perioperative red blood cell and component transfusion and functional health-related quality of life 6 to 12 months after cardiac surgery...
  39. ncbi Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie
    M Maegele
    Department of Trauma and Orthopedic Surgery, and Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Cologne, Germany
    Vox Sang 95:112-9. 2008
    ..To test whether an acute transfusion practice of packed red blood cells (pRBC) : fresh-frozen plasma (FFP) 1 : 1 would be associated with reduced mortality in acute bleeding multiply injury...
  40. pmc Effects of transfusions in extremely low birth weight infants: a retrospective study
    Olga A Valieva
    Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195 6320, USA
    J Pediatr 155:331-37.e1. 2009
    ..We hypothesized that when ELBW infants underwent transfusion with the University of Washington Neonatal Intensive Care Unit (NICU) 2006 guidelines, no clinical benefit would be discernible...
  41. ncbi Anemia and blood transfusion in critically ill patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, 1070, Belgium
    JAMA 288:1499-507. 2002
    ..Anemia is a common problem in critically ill patients admitted to intensive care units (ICUs), but the consequences of anemia on morbidity and mortality in the critically ill is poorly defined...
  42. ncbi The Age of Blood Evaluation (ABLE) randomized controlled trial: study design
    Jacques Lacroix
    Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Faculty of Medicine, Universite de Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
    Transfus Med Rev 25:197-205. 2011
    ....
  43. ncbi Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgery
    Alexander Kulier
    Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austri
    Circulation 116:471-9. 2007
    ..Thus, we determined the effects of low preoperative hemoglobin and comorbidities on postoperative adverse outcomes in patients with coronary artery bypass graft in a large comprehensive multicenter study...
  44. ncbi Age of transfused red cells and early outcomes after cardiac surgery
    Cheng Hon Yap
    Department of Cardiothoracic Surgery, University of Melbourne, St Vincent s Hospital Melbourne, Fitzroy, Victoria, Australia
    Ann Thorac Surg 86:554-9. 2008
    ..The clinical significance of these changes in the cardiac surgical setting is unclear. This observational cohort study investigates the association between age of transfused RBC and early outcomes after cardiac surgery...
  45. ncbi Risk for postoperative infection after transfusion of white blood cell-filtered allogeneic or autologous blood components in orthopedic patients undergoing primary arthroplasty
    Petra Innerhofer
    Department of Anesthesia and Critical Care Medicine, University of Innsbruck, Innsbruck, Austria
    Transfusion 45:103-10. 2005
    ..This study was designed to obtain data on the incidence of postoperative infection in patients undergoing elective orthopedic surgery and receiving white blood cell (WBC)-filtered blood components prepared according to current standards...
  46. ncbi Temporal trends in red blood transfusion among US dialysis patients, 1992-2005
    Hassan N Ibrahim
    Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN, USA
    Am J Kidney Dis 52:1115-21. 2008
    ..Studies addressing patterns and trends in red blood cell transfusion use in US hemodialysis patients surprisingly have received little attention in the last decade...
  47. ncbi Duration of red cell storage before transfusion and in-hospital mortality
    John W Eikelboom
    Department of Medicine, McMaster University, Ontario, Canada
    Am Heart J 159:737-743.e1. 2010
    ..The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospital mortality...
  48. ncbi Outcomes following early red blood cell transfusion in acute upper gastrointestinal bleeding
    S A Hearnshaw
    NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
    Aliment Pharmacol Ther 32:215-24. 2010
    ..Acute upper gastrointestinal bleeding (AUGIB) accounts for 14% of RBC units transfused in the UK. In exsanguinating AUGIB the value of RBC transfusion is self evident, but in less severe bleeding its value is less obvious...
  49. ncbi Red blood cell storage duration and mortality in patients undergoing percutaneous coronary intervention
    Simon D Robinson
    Victoria Heart Institute Foundation, Victoria BC, Canada
    Am Heart J 159:876-81. 2010
    ..We investigated whether RBC storage duration was associated with mortality in patients requiring transfusion after PCI...
  50. ncbi Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion
    Michelle Ng Gong
    Division of Pulmonary, Sleep and Critical Care Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Crit Care Med 33:1191-8. 2005
    ..We describe here the clinical predictors of ARDS risk and mortality including the role of red cell transfusion...
  51. pmc Duration of red cell storage influences mortality after trauma
    Jordan A Weinberg
    Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    J Trauma 69:1427-31; discussion 1431-2. 2010
    ..To overcome this limitation, we compared in-hospital mortality among patients who received exclusively old versus fresh RBC units during the first 24 hours of hospitalization...
  52. ncbi Efficacy of red blood cell transfusion in the critically ill
    Lena M Napolitano
    Department of Surgery, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    Crit Care Clin 20:255-68. 2004
    ....
  53. ncbi Blood component use in critically ill patients
    M P Rao
    National Blood Service Brentwood Centre, Crescent Drive, Brentwood, Essex CM1 8DP, UK
    Anaesthesia 57:530-4. 2002
    ..This study showed that transfusion practice is consistent and that in general there does not seem to be an excessive use of blood components in critically ill patients...
  54. ncbi Status report on the quality of liquid and frozen red blood cells
    C Robert Valeri
    Naval Blood Research Laboratory, Boston University School of Medicine, Boston, MA, USA
    Vox Sang 83:193-6. 2002
  55. ncbi Red blood cell function and blood storage
    N Hamasaki
    Department of Clinical Chemistry and Laboratory Medicine Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Vox Sang 79:191-7. 2000
    ..We also describe the benefits of transfusion of red blood cells having a higher oxygen-delivering capacity. Phosphoenolpyruvate is a promising component to prepare red blood cells having a higher oxygen-delivering capacity...
  56. ncbi [Does red blood cell storage time still influence ICU survival?]
    G Dessertaine
    Service de Reanimation Medicale, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    Transfus Clin Biol 15:154-9. 2008
    ..The purpose of this study was to evaluate the impact of aged leukodepleted-RBC pack, on the outcome of ICU patients...
  57. ncbi [Erythrocyte transfusion: update of the guidelines "therapy with blood components and plasma derivatives"]
    M Welte
    Institut für Anästhesiologie, operative Intensivmedizin und Schmerztherapie, Klinikum Darmstadt, Grafenstrasse 9, 64283, Darmstadt, Deutschland
    Anaesthesist 58:1150-8. 2009
    ....
  58. ncbi Patients with pertrochanteric hip fracture may benefit from preoperative intravenous iron therapy: a pilot study
    Jorge Cuenca
    Department of Orthopedic and Trauma Surgery, Miguel Servet University Hospital, Zaragoza, Spain
    Transfusion 44:1447-52. 2004
    ..Nevertheless, concerns about adverse effects of ABTs have prompted the review of transfusion practice and the search for a safer treatment of perioperative anemia...
  59. ncbi Autologous placental blood transfusion for the therapy of anaemic neonates
    Thomas Brune
    Department of Paediatrics, University of Munster, Germany
    Biol Neonate 81:236-43. 2002
    Almost 65% of all premature neonates with a birth weight <1,500 g receive at least one erythrocyte transfusion during their first weeks of life...
  60. ncbi Duration of red blood cell storage and outcomes following orthotopic liver transplantation
    Lauren K Dunn
    Departments of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Liver Transpl 18:475-81. 2012
    ..In a multivariate model, the MELD-Na score was not associated with increased mortality, and this is consistent with previous studies demonstrating that the MELD-Na score is a poor predictor of long-term survival after transplantation...
  61. ncbi Storage time of transfused red blood cells and impact on clinical outcomes in hematopoietic stem cell transplantation
    Natasha Kekre
    Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Transfusion 51:2488-94. 2011
    ..We examined the impact of RBC transfusion and the age of transfused RBC units on clinical outcomes in hematopoietic stem cell transplantation (HSCT)...
  62. ncbi Low doses of dexamethasone constantly delivered by autologous erythrocytes slow the progression of lung disease in cystic fibrosis patients
    Luigia Rossi
    Institute of Biological Chemistry G Fornaini, University of Urbino, 61029 Urbino, Italy
    Blood Cells Mol Dis 33:57-63. 2004
    ..To evaluate the safety and efficacy of the administration of low doses of glucocorticoids in patients with cystic fibrosis (CF) by using autologous erythrocytes loaded with dexamethasone 21-phosphate...
  63. ncbi Duration of red-cell storage and complications after cardiac surgery
    Colleen Gorman Koch
    Department of Cardiothoracic Anesthesia, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 358:1229-39. 2008
    ..We tested the hypothesis that serious complications and mortality after cardiac surgery are increased when transfused red cells are stored for more than 2 weeks...
  64. ncbi Transfusion therapy in critically ill children
    Tai Tsung Chang
    Pediatric Hematology Oncology, Kaohsiung Medical University Hospital and School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Pediatr neonatol 49:5-12. 2008
    ..The principle: complications of transfusion must be avoided, the rate of blood exposure should be reduced and the safety of the transfused agents or components should be maintained must always be kept in mind...
  65. ncbi Hemodynamic changes in anemic premature infants: are we allowing the hematocrits to fall too low?
    Arie L Alkalay
    Division of Neonatology, Department of Pediatrics, Ahmanson Pediatric Center, University of California at Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Pediatrics 112:838-45. 2003
    ..We evaluated clinical changes and hemodynamic changes by echocardiogram in "stable" anemic premature infants before, during, and after transfusion...
  66. ncbi Interactions of cardiopulmonary bypass and erythrocyte transfusion in the pathogenesis of pulmonary dysfunction in Swine
    Nishith N Patel
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    Anesthesiology 119:365-78. 2013
    Allogeneic erythrocyte transfusion in cardiac surgical patients is associated with a fourfold increase in pulmonary complications...
  67. ncbi The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States
    Howard L Corwin
    Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Crit Care Med 32:39-52. 2004
    ..To quantify the incidence of anemia and red blood cell (RBC) transfusion practice in critically ill patients and to examine the relationship of anemia and RBC transfusion to clinical outcomes...
  68. ncbi The appropriateness of red blood cell use and the extent of overtransfusion: right decision? Right amount?
    Paul J Barr
    Centre for Excellence in Public Health, Queens University Belfast, the Clinical Research Support Centre, Royal Hospitals, Belfast, Northern Ireland
    Transfusion 51:1684-94. 2011
    ..This study aimed to ascertain the levels of inappropriate practice and factors associated with it...
  69. ncbi Red blood cell storage is associated with length of stay and renal complications after cardiac surgery
    Julie Sanders
    From the UCL Centre for Cardiovascular Genetics, and UCL Institute for Human Health and Performance, University College London, London, UK
    Transfusion 51:2286-94. 2011
    ..The association of red blood cell (RBC) storage on morbidity outcome after cardiac surgery is debated. We sought to clarify the association of the age of transfused blood on outcome in patients undergoing cardiac surgery...
  70. ncbi Costs of outpatient red blood cell transfusions
    Winston Ueno
    J Support Oncol 4:494-5. 2006
  71. ncbi Frequency of red cell alloimmunization in patients with sickle cell anemia in an Egyptian referral hospital
    Rabab Aly
    Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    Transfus Apher Sci 47:253-7. 2012
    ..Among other risk categories, alloimmunization to red cell antigens may result from transfusions. The objective of this study was to explore the frequency of red cell alloantibodies among SCA patients who received regular transfusions...
  72. pmc HLA alloimmunization is associated with RBC antibodies in multiply transfused patients with sickle cell disease
    Marianne E McPherson
    AFLAC Cancer Center and Blood Disorders Services, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatr Blood Cancer 54:552-8. 2010
    ..The prevalence and risk factors for HLA alloimmunization in multiply transfused pediatric SCD patients are unknown...
  73. ncbi Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells
    Jeanne E Hendrickson
    Department of Pediatric Hematology Oncology, Emory University School of Medicine, Children s Healthcare of Atlanta, Aflac Cancer Center and Blood Disorders Service, Atlanta, Georgia 30322, USA
    Transfusion 46:1526-36. 2006
    ..In this context, it was hypothesized that the inflammatory status of a transfusion recipient would influence immunization to transfused RBCs...
  74. ncbi [Red blood cell immunization in haemoglobinopathie: about 84 cases]
    I Ben Amor
    Centre régional de transfusion sanguine de Sfax, angle Magida Boulila, Sfax, Tunisie
    Transfus Clin Biol 19:345-52. 2012
    ..To estimate the rate of red cell immunization in hemoglobinopathies...
  75. ncbi The role of inflammation in alloimmunization to antigens on transfused red blood cells
    James C Zimring
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Opin Hematol 15:631-5. 2008
    ..To discuss how inflammation affects humoral alloimmunization to antigens on transfused red blood cells (RBCs)...
  76. ncbi Transfer of glycosylphosphatidylinositol-anchored proteins to deficient cells after erythrocyte transfusion in paroxysmal nocturnal hemoglobinuria
    Elaine M Sloand
    Hematology Branch, National Heart, Lung, and Blood Institute, Department of Transfusion Meidcine, Clinical Center, National Instittues of Health, Bethesda, MD 20892, USA
    Blood 104:3782-8. 2004
    ..Increased surface CD59 was measured on recipient red cells and granulocytes 1, 3, and 7 days following transfusion in all 6 patients. Our data suggest a potential therapeutic role for GPI-anchored protein transfer for severe PNH...
  77. ncbi Costs associated with blood transfusions in Sweden--the societal cost of autologous, allogeneic and perioperative RBC transfusion
    A H Glenngård
    The Swedish Institute for Health Economics IHE, Lund, Sweden
    Transfus Med 15:295-306. 2005
    ..The administration cost was found to be much higher for autologous transfusions compared with allogeneic transfusions. The cost of intraoperative erythrocyte salvage was calculated to be SEK 2567 (285 Euro) per transfusion (>4 units)...
  78. ncbi Postpartum hemorrhage and transfusion of blood and blood components
    A J G Jansen
    Sanquin Blood Bank South West Region, Rotterdam, The Netherlands
    Obstet Gynecol Surv 60:663-71. 2005
    ..In this review, etiology, epidemiology, treatment, and prevention of postpartum hemorrhage are described. Special attention is given to the role of RBC transfusion in the treatment of PPH and the effects of RBC transfusion on HRQoL...
  79. pmc Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs
    Nicole H Smith
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 119:1566-9. 2012
    ..BR mice transfused with membrane-bound hen egg lysozyme antigen-transgenic RBCs also demonstrated induced nonresponsiveness. These data demonstrate that RBCs transfused in the absence of inflammation can induce tolerance...
  80. ncbi Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality?
    Christophe Lelubre
    Department of Intensive Care Medicine, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Transfusion 49:1384-94. 2009
    ..The duration of red blood cell (RBC) storage before transfusion may alter RBC function and, therefore, influence the incidence of complications...
  81. ncbi Practice and costs of red blood cell (RBC) transfusion in an oncological unit
    Jan Norum
    Department of Oncology, University Hospital of North Norway, Tromsø
    Anticancer Res 28:459-64. 2008
    ..Cancer related anemia impairs patient functioning. Red blood cell (RBC) transfusion and erythropoietin (EPO) may relieve fatigue. Cost-effectiveness data have been requested...
  82. ncbi Darbepoetin alfa in lung cancer patients on chemotherapy: a retrospective comparison of outcomes in patients with mild versus moderate-to-severe anaemia at baseline
    J Vansteenkiste
    Respiratory Oncology Unit Pulmonology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Support Care Cancer 12:253-62. 2004
    ..We report several analyses of data from a phase III trial of darbepoetin alfa versus placebo, comparing outcomes for patients with mild and moderate-to-severe anaemia...
  83. ncbi Hyperhemolytic transfusion reaction attributable to anti-Fy3 in a patient with sickle cell disease
    M A Reyes
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Immunohematology 24:45-51. 2008
    ..To the best of our knowledge, this is the first published case of hyperhemolysis in sickle cell disease attributable to anti-Fy3...
  84. pmc Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model
    Maxime Desmarets
    Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 114:2315-22. 2009
    ..Cellular immunization to mHAs is neither monitored nor managed by current transfusion medicine practice; however, the current data suggest that mHAs on RBCs may represent an unappreciated and significant consequence of RBC transfusion...
  85. ncbi Early packed red blood cell transfusion and acute respiratory distress syndrome after trauma
    Onuma Chaiwat
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, Washington 98195 6540, USA
    Anesthesiology 110:351-60. 2009
    ..Transfusion of packed red blood cells (PRBCs) is a risk factor for acute respiratory distress syndrome (ARDS) in trauma patients. Yet, there is a paucity of information regarding the risk of ARDS with incremental PRBCs exposure...
  86. ncbi The cost-effectiveness of treatment with erythropoietin compared to red blood cell transfusions for patients with chemotherapy induced anaemia: a Markov model
    Sixten Borg
    The Swedish Institute for Health Economics IHE, Lund, Sweden
    Acta Oncol 47:1009-17. 2008
    ..It is generally accepted that symptomatic anaemia should be corrected. Treatment options include red blood cell transfusion (RBCT), erythropoietin (EPO) administration or a combination of both...
  87. ncbi Clinical outcomes of ABO-incompatible RBC transfusions
    Kim A Janatpour
    Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento 95817, USA
    Am J Clin Pathol 129:276-81. 2008
    ..Prompt recognition and discontinuation of the transfusion are critical because transfusing less ABO-incompatible blood may minimize signs and symptoms and may prevent death...
  88. pmc The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantation
    Zejing Wang
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
    Br J Haematol 149:101-10. 2010
    ..ABO incompatibility did not affect nonmyeloablative HCT outcomes...
  89. ncbi Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings
    F Weissinger
    Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, USA
    Blood 98:3584-8. 2001
    ....
  90. pmc Transfusion of red cells in hematopoietic stem cell transplantation (TRIST): study protocol for a randomized controlled trial
    Jason Tay
    The Ottawa Hospital Blood and Marrow Programme, The Ottawa Hospital, Ottowa, Canada
    Trials 12:207. 2011
    ....
  91. ncbi Adequacy of physician documentation of red blood cell transfusion and correlation with assessment of transfusion appropriateness
    Mark T Friedman
    Department of Pathology and Laboratory Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
    Arch Pathol Lab Med 130:474-9. 2006
    ..A major function of the hospital transfusion service is to assess the appropriateness of blood transfusion. Inadequate documentation of transfusions may hamper this assessment process...
  92. ncbi Which groups of patients are transfused? A study of red cell usage in London and southeast England
    S J Stanworth
    National Blood Service London and South East, Crescent Drive, Brentwood, Essex CM15 8DP, UK
    Vox Sang 83:352-7. 2002
    ..The aim of this survey was to identify major specialty users of blood to target for audit of transfusion practice with a view to minimizing inappropriate use and to support planning of blood supply needs for the future...
  93. ncbi Association of RBC transfusion with mortality in patients with acute lung injury
    Giora Netzer
    Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, MSTF Bldg, Room 800, 685 W Baltimore St, Baltimore, MD 21201, USA
    Chest 132:1116-23. 2007
    ..RBC transfusion has been associated with increased morbidity and mortality in a variety of clinical settings. We assessed the effect of RBC transfusion on in-hospital mortality in patients with acute lung injury (ALI)...
  94. pmc Liberal or restrictive transfusion in high-risk patients after hip surgery
    Jeffrey L Carson
    Division of General Internal Medicine, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    N Engl J Med 365:2453-62. 2011
    ..We conducted a randomized trial to determine whether a higher threshold for blood transfusion would improve recovery in patients who had undergone surgery for hip fracture...
  95. ncbi The association of perioperative red blood cell transfusions and decreased long-term survival after cardiac surgery
    Stephen D Surgenor
    Dartmouth Hitchcock Medical Center, Department of Surgery, 1 Medical Center Drive Lebanon, NH 03756, USA
    Anesth Analg 108:1741-6. 2009
    ..Exposure to red blood cell (RBC) transfusions has been associated with increased mortality after cardiac surgery. We examined long-term survival for cardiac surgical patients who received one or two RBC units during index hospitalization...
  96. ncbi Appropriateness of allogeneic red blood cell transfusion: the international consensus conference on transfusion outcomes
    Aryeh Shander
    Department of Anesthesiology, Critical Care and Hyperbaric Medicine, Englewood Hospital and Medical Center, 350 Engle Street, Englewood, NJ 07631, USA
    Transfus Med Rev 25:232-246.e53. 2011
    ..In addition, the large number of scenarios in which RBC transfusions were rated as uncertain can serve as a road map to identify areas in need of further investigation...
  97. ncbi Efficacy of allogeneic red blood cell transfusions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 21:209-19. 2007
    ..In this article, several key factors influencing the systemic and regional efficacy of blood transfusion will be reviewed...
  98. pmc Impact of safety concerns and regulatory changes on the usage of erythropoiesis-stimulating agents and RBC transfusions
    Saroj Vadhan-Raj
    Department of Sarcoma Medical Oncology, Section of Cytokines and Supportive Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Oncologist 15:1359-69. 2010
    ..Safety concerns raised in the recent oncology trials with erythropoiesis-stimulating agents (ESAs) have led to regulatory restrictions on their use. We wished to determine the impact of these changes on the use of ESAs and RBC transfusions...
  99. ncbi RBC transfusion requirements after allogeneic marrow transplantation: impact of the before-transplant Hb level on transfusion and early survival
    Anargyros Xenocostas
    Hematology Division, London Health Sciences Center, University of Western Ontario, Canada
    Transfusion 43:373-82. 2003
    ....
  100. ncbi A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantation
    Kathryn E Webert
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Transfusion 48:81-91. 2008
    ..Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia...
  101. ncbi Reduced hemoglobin on day of peripheral blood progenitor cell collection is associated with low graft content of vascular progenitors and increased toxicity after autologous hematopoietic stem cell transplantation
    Gurnaam Kasbia
    Division of Hematology, Blood and Marrow Transplant Program, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 48:2421-8. 2008
    ..The aim was to determine the importance of pretransplant anemia on toxicity and red blood cell (RBC) transfusion requirements after autologous HSCT...

Research Grants64

  1. Fully Biodegradable Polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-b
    PAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2010
    ..Significant additional advantages will be a tremendous cost savings to the health care system in reduced operating costs, as well as enormous job creation and economic stimulus. ..
  2. High-Tc susceptometer to monitor transfusional iron overload (NSR device)
    Gary M Brittenham; Fiscal Year: 2012
    ..abstract_text> ..
  3. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    ....
  4. Transfusion Trigger Trial in Coronary Artery Disease: A Pilot Study
    JEFFREY LEE CARSON; Fiscal Year: 2010
    ....
  5. FOCUS
    JEFFREY LEE CARSON; Fiscal Year: 2011
    ..abstract_text> ..
  6. FOCUS Data Coordinating Center
    Michael L Terrin; Fiscal Year: 2010
    ..abstract_text> ..
  7. Mechanisms underlying the harmful effects of stored red blood cell transfusions
    ELDAD ARIE HOD; Fiscal Year: 2013
    ....
  8. Role of RAGE in Transfusion Mediated Acute Lung Injury
    NILAM S MANGALMURTI; Fiscal Year: 2013
    ....
  9. Comparative Effectiveness: Erythropoietic Stimulating Agents in Treatment of MDS
    Amy J Davidoff; Fiscal Year: 2010
    ..We will examine the characteristics of Medicare beneficiaries with MDS, patterns of treatment, safety and effectiveness of ESA use, and costs of care. ..
  10. Harmful effects of red blood cell transfusions are mediated by iron
    Steven L Spitalnik; Fiscal Year: 2013
    ..This new information will help identify ways to improve the safety of RBC transfusions in hospitalized patients. ..
  11. Feasibility of Expert System to Promote African American Blood Donation for SCD
    Mark L Robbins; Fiscal Year: 2010
    ....
  12. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John D Roback; Fiscal Year: 2010
    ..We anticipate that commercialization of the AEGIS will reduce the incidence of incompatible transfusions and thus improve transfusion outcomes and patient safety. ..
  13. Adverse effects of RBC transfusions: A unifying hypothesis
    John D Roback; Fiscal Year: 2012
    ..However, transfusions are associated with adverse effects. These studies will seek to determine why adverse outcomes happen after transfusion, and develop ways to improve blood collection and storage to minimize these outcomes. ..
  14. Properties of stored RBCs: minimization of immune and vascular reactivity
    Philip J Norris; Fiscal Year: 2012
    ..Importantly, the proposal will validate the knowledge gained and systems developed in a human clinical trial and will evaluate methods of preventing harmful effects of RBC storage using in vitro systems. ..
  15. TRANSFUSION BIOLOGY AND MEDICINE
    Pearl Toy; Fiscal Year: 2005
    ..The ultimate goals of this program are to make optimal use of blood products, to evaluate and possibly modify the immune effects and understand and possibly stimulate blood production so as to reduce transfusion needs. ..
  16. The Role of Nitric Oxide in Red Blood Cell Transfusion
    KYLA BENNETT; Fiscal Year: 2009
    ..Delineating the importance and function of NO in transfusion is pivotal to this process. It is expected to advance both conventional transfusion practice as well as successful production of synthetic blood products. ..
  17. VIRALLY INACTIVATED HUMAN RED CELLS FOR TRANSFUSION
    Andrei Purmal; Fiscal Year: 2004
    ..The results of these studies will set the stage for pivotal clinical trials to be carried out during the five year time-frame of this proposal. ..
  18. A PLASMA COLLECTION DEVICE FOR RED CELL CONSERVATION
    Michael Jaeger; Fiscal Year: 2000
    ..abstract_text> ..
  19. Erythrocyte Transfusion in Acute Lung Injury During Sepsis
    Nilam Mangalmurti; Fiscal Year: 2009
    ..We have developed an in vivo murine model whereby purified erythrocyte transfusion promotes neutrophilic accumulation in the lungs...
  20. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  21. Pediatric Clinical Research Scholar Program - Washington
    Naomi Luban; Fiscal Year: 2007
    ..abstract_text> ..
  22. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002
    ..abstract_text> ..
  23. Tolerance to Carbohydrate Antigens in Transplantation
    David Cooper; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Induction of Immunological Tolerance for Gene Therapy
    JAMES ZIMRING; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  25. CD8 + CD75s + regulatory T cells in anti-tumor immunity
    JAMES ZIMRING; Fiscal Year: 2007
    ..These aims propose to investigate the role that negative regulatory T cells play in the establishment of immunological tolerance to tumor antigens and the fashion in which their elimination can result in tumor rejection. ..
  26. Alloimmunization to mHAs by RBC Transfusion
    JAMES ZIMRING; Fiscal Year: 2007
    ..By analyzing transfusion patients at Emory, we will determine the extent to which females receiving leukoreduced RBC from male donors are immunized to H-Y antigens. [unreadable] [unreadable] [unreadable]..
  27. Physician Training Program in Neonatal Biology
    John Widness; Fiscal Year: 2007
    ..With NIH support beyond that which the investigators currently enjoy, the investigators will be able to significantly enhance the research training experiences they offer their postdoctoral physician trainees in neonatal medicine. ..
  28. Blood Filter to Remove Pathogen Inactivation Compound
    John Chapman; Fiscal Year: 2005
    ..3. Construct "proof of concept" prototype filters meeting defined performance specifications. ..
  29. The role of Ach in CD8+ Cytolytic T cell development
    JAMES ZIMRING; Fiscal Year: 2005
    ..abstract_text> ..
  30. Thromboregulation to Prevent Thrombotic Microangiopathy
    David Cooper; Fiscal Year: 2008
    ..It is anticipated that these approaches will abrogate the development of TM and allow long-term survival of pig organs in baboons. ..
  31. Selective depletion of alloreactive T cells in BMT
    JAMES ZIMRING; Fiscal Year: 2005
    ..In keeping with the stated purpose of this RFA, these studies represent the "development and application of cell engineering methods to predictably induce tolerance..." ..
  32. INDICES OF BIOTIN NUTRITION
    Donald Mock; Fiscal Year: 2001
    ..4) Whether biotin deficiency of similar severity to that observed either early or late in human gestation causes increased rates of fetal malformation in the mouse. 5) The enzyme(s) responsible for biotin beta-oxidation. ..
  33. MIDCAREER AWARD IN PATIENT ORIENTED OBSTETRIC RESEARCH
    Dwight Rouse; Fiscal Year: 2004
    ..Finally, the effectiveness of an intervention (how it would perform under conditions of actual clinical practice) is an attribute that, in many situations, is as important as its efficacy (how it performs under ideal conditions). ..
  34. Rapid quantitation of residual WBCs in filtered blood
    John Roback; Fiscal Year: 2004
    ....
  35. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  36. FOCUS Hip Fracture Transfusion Trial: Delirium and Other Cognitive Outcomes
    Ann L Gruber Baldini; Fiscal Year: 2010
    ..This ancillary study examines whether transfusion helps prevent short-term (post- randomization) and long-term (30 day) changes in delirium. ..
  37. Modulation of Iron Deposition in SCD and Other Hemoglobinopathies
    ELLIOTT P contact VICHINSKY; Fiscal Year: 2010
    ....
  38. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2004
    ..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..
  39. Aminocaproic Acid and Bleeding in Spinal Surgery
    Sean Berenholtz; Fiscal Year: 2006
    ..These projects and the career development plan described will build a foundation for a successful career as an independent investigator. ..
  40. Inducing Immune Tolerance with Receptor Modified T Cells
    Terrence Geiger; Fiscal Year: 2003
    ..Together this information will provide a starting point for the application of GM-TCs to human immunologic conditions. ..
  41. ERYTHROCYTAPHERESIS TO LOWER IRON LOADING IN THALASSEMIA
    Alan Cohen; Fiscal Year: 2002
    ....
  42. COST EFFECTIVENESS OF GENETIC SCREENING FOR COLON CANCER
    Scott Ramsey; Fiscal Year: 2002
    ....
  43. FACSVantage SE Sorting Flow Cytometer
    Jane Barker; Fiscal Year: 2002
    ..Funds are requested to purchase the FACSVantage SE and the optional equipment for TJL's Flow Cytometry Service. This will provide a cost-effective way to fill an urgent need of TJL's principal investigators. ..
  44. VASCULAR BED SPECIFIC EXPRESSION OF A VWF TRANSGENE
    WILLIAM AIRD; Fiscal Year: 2001
    ..Taken together, these studies should provide important information about the mechanisms of endothelial cell heterogeneity and vascular diversity. ..
  45. CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIA
    Chaim Hershko; Fiscal Year: 2001
    ..abstract_text> ..
  46. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  47. Chlamydia Infection as a Risk Factor for Cerebrovascula*
    Lori Styles; Fiscal Year: 2004
    ..The data gained in this proposal would provide the preliminary data necessary to justify further clinical trials. ..
  48. Induction of Stable Chimerism for Sickle Cell Anemia
    Mark Walters; Fiscal Year: 2004
    ..If successful, this novel approach will expand the availability of HCT for patients with clinically significant hemoglobinopathies. ..
  49. A Genetic Screening Policy Model for Colorectal Cancer
    Scott Ramsey; Fiscal Year: 2006
    ..The model will incorporate QOL information from Aim 2, along with family history, clinical, and screening information from the Seattle CFR. ..
  50. Automated high-throughput detection anti-HLA antibodies
    John Roback; Fiscal Year: 2006
    ..This application proposes to develop a test that could be used to screen blood donors for these antibodies, thus preventing TRALI and improving patient outcomes. [unreadable] [unreadable] [unreadable]..
  51. Beta-Blockade Reduces Catabolism in Severely Injured Trauma Patients
    Jeffrey Johnson; Fiscal Year: 2007
    ..This information will provide a platform from which to launch both basic science and clinical research into the (-adrenergic system and its effects on inflammation, catabolism, and functional outcome [unreadable] [unreadable]..
  52. PICU Nosocomial Infections: Epidemiology and Outcomes
    Alexis Elward; Fiscal Year: 2007
    ....
  53. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. Erythrocyte Nitrosothiol Flux and Vasoregulation in Lung
    Allan Doctor; Fiscal Year: 2008
    ..The candidate's long-term goal is to define the mechanism of NO traffic between regional vascular beds via the erythrocyte, and its role in the evolution of multiple organ failure in severe inflammatory states. ..
  55. VEGF, Transcriptional Networks and Vascular Inflammation
    William C Aird; Fiscal Year: 2010
    ..abstract_text> ..
  56. ITEM BANKING AND CAT FOR QUALITY OF LIFE OUTCOMES
    David Cella; Fiscal Year: 2008
    ..We will also monitor treatment/management changes, and evaluate acceptability of computer assessments and the perceived benefits of the recommendations. ..
  57. Northern California Consortium for Sickle Cell Disease
    Mark Walters; Fiscal Year: 2008
    ..abstract_text> ..
  58. MOLECULAR BASIS FOR TS TRANSLATIONAL REGULATION
    Edward Chu; Fiscal Year: 2005
    ..Moreover, these molecular-based studies may provide the rational basis for the development of novel therapeutic strategies for human cancer. ..
  59. Development of an ABO Incompatibility Stop Device (AISD)
    Christopher Hillyer; Fiscal Year: 2008
    ..If the unit is not compatible, the transfusion is not allowed to proceed. This should stop all mistransfusion and the related deaths. [unreadable] [unreadable] [unreadable]..
  60. Cell Death and Clonal Survival in Myelodysplastic Syndr*
    H Deeg; Fiscal Year: 2008
    ..To achieve these objectives, we must better understand the underlying mechanisms of MDS and thereby identify ways by which the disease process can be arrested, progression prevented, and the disease hopefully be cured. ..
  61. Acute Lung Injury after Trauma: Predicting its Onset and Identifying Novel Risks
    TIMOTHY WATKINS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  62. E/BETA THALASSEMIA--NATURAL HISTORY & RESPONSE TO CHEMO
    Elliott Vichinsky; Fiscal Year: 2002
    ..In summary, if this study is successful, it will change the approach to Hb E/B worldwide and result in improved quality of life and decreased mortality. (End of Abstract) ..
  63. Eighth Cooley's Anemia Symposium
    Elliott Vichinsky; Fiscal Year: 2005
    ....
  64. NOVEL THERAPEUTIC STRATEGIES IN MYELODYSPLASTIC SYNDROME
    H Deeg; Fiscal Year: 2003
    ..Optimization of therapy, in turn, should reduce morbidity and mortality associated with MDS and improve the quality of life of patients with MDS. ..