Genomes and Genes
Summary: The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
Publications275 found, 100 shown here
- Clinical consequences of red cell storage in the critically illAlan Tinmouth
Center for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
Transfusion 46:2014-27. 2006..These data suggest a possible detrimental clinical effect associated with the transfusion of stored RBCs; randomized clinical trials further evaluating the clinical consequences of transfusing older stored RBCs are required...
- The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospitalMatthew A Borgman
Brooke Army Medical Center, Fort Sam Houston, TX, USA
J Trauma 63:805-13. 2007..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
- Clinical practice guideline: red blood cell transfusion in adult trauma and critical careLena M Napolitano
Crit Care Med 37:3124-57. 2009..To develop a clinical practice guideline for red blood cell transfusion in adult trauma and critical care...
- Red blood cell transfusion practice in patients presenting with acute upper gastrointestinal bleeding: a survey of 815 UK cliniciansVipul Jairath
NHS Blood and Transplant and Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
Transfusion 51:1940-8. 2011..We aimed to survey UK clinicians about their RBC transfusion practice in AUGIB...
- Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trialsJulia Bohlius
Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
Lancet 373:1532-42. 2009..We therefore did a meta-analysis of randomised controlled trials in which these drugs plus red blood cell transfusions were compared with transfusion alone for prophylaxis or treatment of anaemia in patients with cancer...
- Definitions of the phenotypic manifestations of sickle cell diseaseSamir K Ballas
Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Thomas Jefferson University, 1015 Walnut Street, Philadelphia, PA 19107, USA
Am J Hematol 85:6-13. 2010....
- Umbilical cord milking reduces the need for red cell transfusions and improves neonatal adaptation in infants born at less than 29 weeks' gestation: a randomised controlled trialS Hosono
Dr S Hosono, Department of Paediatrics and Child Health, Nihon University School of Medicine, 30 1 Oyaguchi Itabashi, Tokyo 173 8610, Japan
Arch Dis Child Fetal Neonatal Ed 93:F14-9. 2008..To investigate the effects of umbilical cord milking on the need for red blood cell (RBC) transfusion and morbidity in very preterm infants...
- Age of red blood cells and mortality in the critically illVille Pettila
Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Commercial Road, Melbourne 3004, Victoria, Australia
Crit Care 15:R116. 2011..We hypothesized that exposure to even a single unit of older RBCs may be associated with an increased risk of death...
- Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patientsLeo van de Watering
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
Transfusion 46:1712-8. 2006..The aim in this study was to investigate the possible role of the storage time of RBC transfusions on the outcome of coronary artery bypass graft (CABG) surgery patients...
- Effect of duration of red blood cell storage on early and late mortality after coronary artery bypass graftingAlbert H M van Straten
Department of Cardio Thoracic Surgery, Catharina Hospital, Eindhoven, The Netherlands
J Thorac Cardiovasc Surg 141:231-7. 2011..We tested the hypothesis that longer storage of transfused red blood cells increases the risk of early and late mortality in patients who undergo coronary artery bypass grafting...
- Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitorJohn A Widness
Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa, USA
Pediatrics 115:1299-306. 2005..To date, researchers have had only limited success in finding ways to reduce transfusions significantly in this patient population...
- Red blood cell transfusion is associated with increased rebleeding in patients with nonvariceal upper gastrointestinal bleedingS Restellini
Department of Medical Specialities, Division of Gastroenterology and Hepatology, Geneva s University Hospitals and University of Geneva, Geneva, Switzerland
Aliment Pharmacol Ther 37:316-22. 2013..Studies in other critically ill cohorts suggest associations between transfusions and adverse patient outcomes...
- The effect of older blood on mortality, need for ICU care, and the length of ICU stay after major traumaZuri Murrell
Department of Surgery, Harbor UCLA Medical Center, 1000 W Carson St, Box 15, Torrance, CA 90509, USA
Am Surg 71:781-5. 2005..87-1.64). The quantity of aged blood is an independent risk factor for length of ICU care. This may be a proxy indicator for multiple organ failure. Further research is required to define which patients may benefit from newer blood...
- Storage time of allogeneic red blood cells is associated with risk of severe postoperative infection after coronary artery bypass graftingJan Jesper Andreasen
Department of Cardiothoracic Surgery, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
Eur J Cardiothorac Surg 39:329-34. 2011..We therefore examined the association between the age of transfused RBCs and development of severe postoperative infection following coronary artery bypass grafting (CABG) in a large population-based cohort study...
- Proof of principle for transfusion of in vitro-generated red blood cellsMarie Catherine Giarratana
UPMC Paris, UMR_S938 CDR Saint Antoine, Prolifération et Différenciation des Cellules Souches, France
Blood 118:5071-9. 2011..These data establish the proof of principle for transfusion of in vitro-generated RBCs and path the way toward new developments in transfusion medicine. This study is registered at http://www.clinicaltrials.gov as NCT0929266...
- A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5qPierre Fenaux
Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris XIII, Bobigny, France
Blood 118:3765-76. 2011..Lenalidomide is beneficial and has an acceptable safety profile in transfusion-dependent patients with Low-/Intermediate-1-risk del5q myelodysplastic syndrome. This trial was registered at www.clinicaltrials.gov as #NCT00179621...
- Red blood cell transfusion in clinical practiceHarvey G Klein
Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
Lancet 370:415-26. 2007..Despite serious immunological and non-immunological complications, RBC transfusion holds a therapeutic index that exceeds that of many common medications...
- Transfusion-related immunomodulation (TRIM): an updateEleftherios C Vamvakas
Department of Pathology and Laboratory Medicine, University of Ottawa, Faculty of Medicine, Canada
Blood Rev 21:327-48. 2007....
- Activity-based costs of blood transfusions in surgical patients at four hospitalsAryeh Shander
The Institute for Patient Blood Management and Bloodless Medicine at Englewood Hospital and Medical Center, Englewood, New Jersey, USA
Transfusion 50:753-65. 2010..Determining the cost of supplying patients with blood transfusions requires an in-depth examination of the complex array of activities surrounding the decision to transfuse...
- Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60 years?Juan C Duchesne
Division of Trauma Critical Care Surgery, Department of Surgery, Tulane University School of Medicine New Orleans, Louisiana 70112 2699, USA
J Trauma 65:272-6; discussion 276-8. 2008..We hypothesize a similar improvement in mortality in civilian trauma patients that require massive transfusion and are treated with a FFP to PRBC ratio closer to 1:1...
- Blood use in elective surgery: the Austrian benchmark studyHans Gombotz
Department of Anesthesiology and Intensive Care, General Hospital Linz, Krankenhausstrasse 9, A 4020 Linz, Austria
Transfusion 47:1468-80. 2007..The goal of this study was to measure and to compare the current transfusion practice and to identify predictors of transfusion in public hospitals to develop strategies to optimize transfusion practices...
- A survey of the demographics of blood useT J Cobain
Department of Haematology and Genetics, South Eastern Area Laboratory Services, Sydney, Australia
Transfus Med 17:1-15. 2007..In Australia, red cell use of >or=50 units per episode was largely associated with multiple traumas. In Denmark, it was associated with gastrointestinal bleeding and various medical requests...
- A mathematical model of erythropoiesis in mice and rats. Part 4: Differences between bone marrow and spleenK Pantel
Medizinische Universitatsklinik I, LFI EDV, Koln, F R G
Cell Tissue Kinet 23:283-97. 1990....
- Changing indications for red cell transfusion from 2000 to 2004 in the North of EnglandJ P Wallis
Department of Haematology, Freeman Hospital, Newcastle upon Tyne, UK
Transfus Med 16:411-7. 2006..Promotion of good transfusion practice and alternatives to allogeneic transfusion should now focus on medical and surgical use of blood transfusion...
- Meta-analysis of clinical studies of the purported deleterious effects of "old" (versus "fresh") red blood cells: are we at equipoise?Eleftherios C Vamvakas
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Transfusion 50:600-10. 2010..Such suspicion is required for intentionally exposing patients enrolled in randomized controlled trials (RCTs) to the known or probable--but rare--risks of old RBCs, to document (and prevent) purported common adverse effects of old RBCs...
- Red blood cell transfusions and nosocomial infections in critically ill patientsRobert W Taylor
St John s Mercy Medical Center, St Louis University, MO, USA
Crit Care Med 34:2302-8; quiz 2309. 2006....
- Reduction in red blood cell transfusions using a bedside analyzer in extremely low birth weight infantsAshima Madan
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
J Perinatol 25:21-5. 2005....
- Red blood cell transfusion during septic shock in the ICUA Perner
Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Acta Anaesthesiol Scand 56:718-23. 2012..Our aim was to evaluate RBC transfusion practice in septic shock in the intensive care unit (ICU), and patient characteristics and outcome associated with RBC transfusion...
- Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort studyChristina Katsios
Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON L8S 4L8, Canada
Crit Care 15:R263. 2011..The objective of this study was to determine if RBC transfusions or RBC storage age predicts incident DVT in medical or surgical intensive care unit (ICU) patients...
- Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcomeA W Bracey
Department of Pathology, Texas Heart Institute St Luke s Episcopal Hospital and Prairie View A and M College of Nursing, Houston 77030, USA
Transfusion 39:1070-7. 1999..The goal of this study was to determine if lowering the hemoglobin threshold for red cell (RBC) transfusion to 8 g per dL after coronary artery bypass graft surgery would reduce blood use without adversely affecting patient outcome...
- Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14-year experience from a single center (CME)Michele Lasalle-Williams
Bonfils Blood Center, Denver, CO 80230, USA
Transfusion 51:1732-9. 2011..Here, we report our experiences with extended RBC antigen matching for SCD patients...
- rs660 polymorphism in Ro52 (SSA1; TRIM21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell diseaseZohreh Tatari-Calderone
Center for Cancer and Immunology Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
Mol Immunol 47:64-70. 2009..These results suggest that rs660 polymorphism is a marker of efficiency of tolerance induction in early childhood and immune competence development to RBC antigens in SCD patients of pre-teen/teen age...
- Transfusion strategies for acute upper gastrointestinal bleedingCandid Villanueva
Gastrointestinal Bleeding Unit, Department of Gastroenterology, Hospital de Sant Pau, Autonomous University, Barcelona, Spain
N Engl J Med 368:11-21. 2013..The hemoglobin threshold for transfusion of red cells in patients with acute gastrointestinal bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy...
- Red blood cell transfusion: a clinical practice guideline from the AABB*Jeffrey L Carson
MD, Division of General Internal Medicine, UMDNJ Robert Wood Johnson Medical School, 125 Paterson Street, New Brunswick, NJ 08903, USA
Ann Intern Med 157:49-58. 2012....
- Anaemia and its functional consequences in cancer patients: current challenges in management and prospects for improving therapyG D Demetri
Center for Sarcoma and Bone Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Br J Cancer 84:31-7. 2001..With this new option for therapy, further avenues of investigation should lead to renewed interest in the clinical benefits of optimal haemoglobin levels for patients with cancer...
- Effect of prophylactic transfusion of stored RBCs on oxygen reserve in response to acute isovolemic hemorrhage in a rodent modelD Gray
Department of Hematology, A.C. Burton Vascular Biology Laboratory, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario, Canada N6A 4G5
Transfusion 41:950-6. 2001..CONCLUSION: The physiologic impact of DPG depletion in transfused stored blood on oxygen availability in normal rats appears to be small and may be clinically inconsequential...
- Impact of transfusion of fresh-frozen plasma and packed red blood cells in a 1:1 ratio on survival of emergency department patients with severe traumaShahriar Zehtabchi
Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
Acad Emerg Med 16:371-8. 2009..This evidence-based emergency medicine (EBM) review evaluates the evidence regarding the impact of 1:1 ratio of FFP:PRBC transfusion on survival of emergency department (ED) patients with severe trauma...
- Persistent effect of red cell transfusion on health-related quality of life after cardiac surgeryColleen Gorman Koch
Department of Cardiothoracic Anesthesia, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
Ann Thorac Surg 82:13-20. 2006..Our objective was to investigate the relationship between perioperative red blood cell and component transfusion and functional health-related quality of life 6 to 12 months after cardiac surgery...
- Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für UnfallchirurgieM Maegele
Department of Trauma and Orthopedic Surgery, and Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Cologne, Germany
Vox Sang 95:112-9. 2008..To test whether an acute transfusion practice of packed red blood cells (pRBC) : fresh-frozen plasma (FFP) 1 : 1 would be associated with reduced mortality in acute bleeding multiply injury...
- Effects of transfusions in extremely low birth weight infants: a retrospective studyOlga A Valieva
Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195 6320, USA
J Pediatr 155:331-37.e1. 2009..We hypothesized that when ELBW infants underwent transfusion with the University of Washington Neonatal Intensive Care Unit (NICU) 2006 guidelines, no clinical benefit would be discernible...
- Anemia and blood transfusion in critically ill patientsJean Louis Vincent
Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, 1070, Belgium
JAMA 288:1499-507. 2002..Anemia is a common problem in critically ill patients admitted to intensive care units (ICUs), but the consequences of anemia on morbidity and mortality in the critically ill is poorly defined...
- The Age of Blood Evaluation (ABLE) randomized controlled trial: study designJacques Lacroix
Division of Pediatric Critical Care, Department of Pediatrics, Sainte Justine Hospital, Faculty of Medicine, Universite de Montreal, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
Transfus Med Rev 25:197-205. 2011....
- Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgeryAlexander Kulier
Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austri
Circulation 116:471-9. 2007..Thus, we determined the effects of low preoperative hemoglobin and comorbidities on postoperative adverse outcomes in patients with coronary artery bypass graft in a large comprehensive multicenter study...
- Age of transfused red cells and early outcomes after cardiac surgeryCheng Hon Yap
Department of Cardiothoracic Surgery, University of Melbourne, St Vincent s Hospital Melbourne, Fitzroy, Victoria, Australia
Ann Thorac Surg 86:554-9. 2008..The clinical significance of these changes in the cardiac surgical setting is unclear. This observational cohort study investigates the association between age of transfused RBC and early outcomes after cardiac surgery...
- Risk for postoperative infection after transfusion of white blood cell-filtered allogeneic or autologous blood components in orthopedic patients undergoing primary arthroplastyPetra Innerhofer
Department of Anesthesia and Critical Care Medicine, University of Innsbruck, Innsbruck, Austria
Transfusion 45:103-10. 2005..This study was designed to obtain data on the incidence of postoperative infection in patients undergoing elective orthopedic surgery and receiving white blood cell (WBC)-filtered blood components prepared according to current standards...
- Temporal trends in red blood transfusion among US dialysis patients, 1992-2005Hassan N Ibrahim
Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN, USA
Am J Kidney Dis 52:1115-21. 2008..Studies addressing patterns and trends in red blood cell transfusion use in US hemodialysis patients surprisingly have received little attention in the last decade...
- Duration of red cell storage before transfusion and in-hospital mortalityJohn W Eikelboom
Department of Medicine, McMaster University, Ontario, Canada
Am Heart J 159:737-743.e1. 2010..The objective of the study was to examine the association between duration of pretransfusion storage of red cells and in-hospital mortality...
- Outcomes following early red blood cell transfusion in acute upper gastrointestinal bleedingS A Hearnshaw
NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK
Aliment Pharmacol Ther 32:215-24. 2010..Acute upper gastrointestinal bleeding (AUGIB) accounts for 14% of RBC units transfused in the UK. In exsanguinating AUGIB the value of RBC transfusion is self evident, but in less severe bleeding its value is less obvious...
- Red blood cell storage duration and mortality in patients undergoing percutaneous coronary interventionSimon D Robinson
Victoria Heart Institute Foundation, Victoria BC, Canada
Am Heart J 159:876-81. 2010..We investigated whether RBC storage duration was associated with mortality in patients requiring transfusion after PCI...
- Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusionMichelle Ng Gong
Division of Pulmonary, Sleep and Critical Care Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
Crit Care Med 33:1191-8. 2005..We describe here the clinical predictors of ARDS risk and mortality including the role of red cell transfusion...
- Duration of red cell storage influences mortality after traumaJordan A Weinberg
Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
J Trauma 69:1427-31; discussion 1431-2. 2010..To overcome this limitation, we compared in-hospital mortality among patients who received exclusively old versus fresh RBC units during the first 24 hours of hospitalization...
- Efficacy of red blood cell transfusion in the critically illLena M Napolitano
Department of Surgery, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
Crit Care Clin 20:255-68. 2004....
- Blood component use in critically ill patientsM P Rao
National Blood Service Brentwood Centre, Crescent Drive, Brentwood, Essex CM1 8DP, UK
Anaesthesia 57:530-4. 2002..This study showed that transfusion practice is consistent and that in general there does not seem to be an excessive use of blood components in critically ill patients...
- Status report on the quality of liquid and frozen red blood cellsC Robert Valeri
Naval Blood Research Laboratory, Boston University School of Medicine, Boston, MA, USA
Vox Sang 83:193-6. 2002
- Red blood cell function and blood storageN Hamasaki
Department of Clinical Chemistry and Laboratory Medicine Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Vox Sang 79:191-7. 2000..We also describe the benefits of transfusion of red blood cells having a higher oxygen-delivering capacity. Phosphoenolpyruvate is a promising component to prepare red blood cells having a higher oxygen-delivering capacity...
- [Does red blood cell storage time still influence ICU survival?]G Dessertaine
Service de Reanimation Medicale, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
Transfus Clin Biol 15:154-9. 2008..The purpose of this study was to evaluate the impact of aged leukodepleted-RBC pack, on the outcome of ICU patients...
- [Erythrocyte transfusion: update of the guidelines "therapy with blood components and plasma derivatives"]M Welte
Institut für Anästhesiologie, operative Intensivmedizin und Schmerztherapie, Klinikum Darmstadt, Grafenstrasse 9, 64283, Darmstadt, Deutschland
Anaesthesist 58:1150-8. 2009....
- Patients with pertrochanteric hip fracture may benefit from preoperative intravenous iron therapy: a pilot studyJorge Cuenca
Department of Orthopedic and Trauma Surgery, Miguel Servet University Hospital, Zaragoza, Spain
Transfusion 44:1447-52. 2004..Nevertheless, concerns about adverse effects of ABTs have prompted the review of transfusion practice and the search for a safer treatment of perioperative anemia...
- Autologous placental blood transfusion for the therapy of anaemic neonatesThomas Brune
Department of Paediatrics, University of Munster, Germany
Biol Neonate 81:236-43. 2002Almost 65% of all premature neonates with a birth weight <1,500 g receive at least one erythrocyte transfusion during their first weeks of life...
- Duration of red blood cell storage and outcomes following orthotopic liver transplantationLauren K Dunn
Departments of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
Liver Transpl 18:475-81. 2012..In a multivariate model, the MELD-Na score was not associated with increased mortality, and this is consistent with previous studies demonstrating that the MELD-Na score is a poor predictor of long-term survival after transplantation...
- Storage time of transfused red blood cells and impact on clinical outcomes in hematopoietic stem cell transplantationNatasha Kekre
Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Transfusion 51:2488-94. 2011..We examined the impact of RBC transfusion and the age of transfused RBC units on clinical outcomes in hematopoietic stem cell transplantation (HSCT)...
- Low doses of dexamethasone constantly delivered by autologous erythrocytes slow the progression of lung disease in cystic fibrosis patientsLuigia Rossi
Institute of Biological Chemistry G Fornaini, University of Urbino, 61029 Urbino, Italy
Blood Cells Mol Dis 33:57-63. 2004..To evaluate the safety and efficacy of the administration of low doses of glucocorticoids in patients with cystic fibrosis (CF) by using autologous erythrocytes loaded with dexamethasone 21-phosphate...
- Duration of red-cell storage and complications after cardiac surgeryColleen Gorman Koch
Department of Cardiothoracic Anesthesia, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
N Engl J Med 358:1229-39. 2008..We tested the hypothesis that serious complications and mortality after cardiac surgery are increased when transfused red cells are stored for more than 2 weeks...
- Transfusion therapy in critically ill childrenTai Tsung Chang
Pediatric Hematology Oncology, Kaohsiung Medical University Hospital and School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Pediatr neonatol 49:5-12. 2008..The principle: complications of transfusion must be avoided, the rate of blood exposure should be reduced and the safety of the transfused agents or components should be maintained must always be kept in mind...
- Hemodynamic changes in anemic premature infants: are we allowing the hematocrits to fall too low?Arie L Alkalay
Division of Neonatology, Department of Pediatrics, Ahmanson Pediatric Center, University of California at Los Angeles School of Medicine, Los Angeles, California 90048, USA
Pediatrics 112:838-45. 2003..We evaluated clinical changes and hemodynamic changes by echocardiogram in "stable" anemic premature infants before, during, and after transfusion...
- Interactions of cardiopulmonary bypass and erythrocyte transfusion in the pathogenesis of pulmonary dysfunction in SwineNishith N Patel
Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, UK
Anesthesiology 119:365-78. 2013Allogeneic erythrocyte transfusion in cardiac surgical patients is associated with a fourfold increase in pulmonary complications...
- The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United StatesHoward L Corwin
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Crit Care Med 32:39-52. 2004..To quantify the incidence of anemia and red blood cell (RBC) transfusion practice in critically ill patients and to examine the relationship of anemia and RBC transfusion to clinical outcomes...
- The appropriateness of red blood cell use and the extent of overtransfusion: right decision? Right amount?Paul J Barr
Centre for Excellence in Public Health, Queens University Belfast, the Clinical Research Support Centre, Royal Hospitals, Belfast, Northern Ireland
Transfusion 51:1684-94. 2011..This study aimed to ascertain the levels of inappropriate practice and factors associated with it...
- Red blood cell storage is associated with length of stay and renal complications after cardiac surgeryJulie Sanders
From the UCL Centre for Cardiovascular Genetics, and UCL Institute for Human Health and Performance, University College London, London, UK
Transfusion 51:2286-94. 2011..The association of red blood cell (RBC) storage on morbidity outcome after cardiac surgery is debated. We sought to clarify the association of the age of transfused blood on outcome in patients undergoing cardiac surgery...
- Costs of outpatient red blood cell transfusionsWinston Ueno
J Support Oncol 4:494-5. 2006
- Frequency of red cell alloimmunization in patients with sickle cell anemia in an Egyptian referral hospitalRabab Aly
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Transfus Apher Sci 47:253-7. 2012..Among other risk categories, alloimmunization to red cell antigens may result from transfusions. The objective of this study was to explore the frequency of red cell alloantibodies among SCA patients who received regular transfusions...
- HLA alloimmunization is associated with RBC antibodies in multiply transfused patients with sickle cell diseaseMarianne E McPherson
AFLAC Cancer Center and Blood Disorders Services, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA
Pediatr Blood Cancer 54:552-8. 2010..The prevalence and risk factors for HLA alloimmunization in multiply transfused pediatric SCD patients are unknown...
- Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cellsJeanne E Hendrickson
Department of Pediatric Hematology Oncology, Emory University School of Medicine, Children s Healthcare of Atlanta, Aflac Cancer Center and Blood Disorders Service, Atlanta, Georgia 30322, USA
Transfusion 46:1526-36. 2006..In this context, it was hypothesized that the inflammatory status of a transfusion recipient would influence immunization to transfused RBCs...
- [Red blood cell immunization in haemoglobinopathie: about 84 cases]I Ben Amor
Centre régional de transfusion sanguine de Sfax, angle Magida Boulila, Sfax, Tunisie
Transfus Clin Biol 19:345-52. 2012..To estimate the rate of red cell immunization in hemoglobinopathies...
- The role of inflammation in alloimmunization to antigens on transfused red blood cellsJames C Zimring
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Curr Opin Hematol 15:631-5. 2008..To discuss how inflammation affects humoral alloimmunization to antigens on transfused red blood cells (RBCs)...
- Transfer of glycosylphosphatidylinositol-anchored proteins to deficient cells after erythrocyte transfusion in paroxysmal nocturnal hemoglobinuriaElaine M Sloand
Hematology Branch, National Heart, Lung, and Blood Institute, Department of Transfusion Meidcine, Clinical Center, National Instittues of Health, Bethesda, MD 20892, USA
Blood 104:3782-8. 2004..Increased surface CD59 was measured on recipient red cells and granulocytes 1, 3, and 7 days following transfusion in all 6 patients. Our data suggest a potential therapeutic role for GPI-anchored protein transfer for severe PNH...
- Costs associated with blood transfusions in Sweden--the societal cost of autologous, allogeneic and perioperative RBC transfusionA H Glenngård
The Swedish Institute for Health Economics IHE, Lund, Sweden
Transfus Med 15:295-306. 2005..The administration cost was found to be much higher for autologous transfusions compared with allogeneic transfusions. The cost of intraoperative erythrocyte salvage was calculated to be SEK 2567 (285 Euro) per transfusion (>4 units)...
- Postpartum hemorrhage and transfusion of blood and blood componentsA J G Jansen
Sanquin Blood Bank South West Region, Rotterdam, The Netherlands
Obstet Gynecol Surv 60:663-71. 2005..In this review, etiology, epidemiology, treatment, and prevention of postpartum hemorrhage are described. Special attention is given to the role of RBC transfusion in the treatment of PPH and the effects of RBC transfusion on HRQoL...
- Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCsNicole H Smith
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Blood 119:1566-9. 2012..BR mice transfused with membrane-bound hen egg lysozyme antigen-transgenic RBCs also demonstrated induced nonresponsiveness. These data demonstrate that RBCs transfused in the absence of inflammation can induce tolerance...
- Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality?Christophe Lelubre
Department of Intensive Care Medicine, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
Transfusion 49:1384-94. 2009..The duration of red blood cell (RBC) storage before transfusion may alter RBC function and, therefore, influence the incidence of complications...
- Practice and costs of red blood cell (RBC) transfusion in an oncological unitJan Norum
Department of Oncology, University Hospital of North Norway, Tromsø
Anticancer Res 28:459-64. 2008..Cancer related anemia impairs patient functioning. Red blood cell (RBC) transfusion and erythropoietin (EPO) may relieve fatigue. Cost-effectiveness data have been requested...
- Darbepoetin alfa in lung cancer patients on chemotherapy: a retrospective comparison of outcomes in patients with mild versus moderate-to-severe anaemia at baselineJ Vansteenkiste
Respiratory Oncology Unit Pulmonology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Support Care Cancer 12:253-62. 2004..We report several analyses of data from a phase III trial of darbepoetin alfa versus placebo, comparing outcomes for patients with mild and moderate-to-severe anaemia...
- Hyperhemolytic transfusion reaction attributable to anti-Fy3 in a patient with sickle cell diseaseM A Reyes
Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
Immunohematology 24:45-51. 2008..To the best of our knowledge, this is the first published case of hyperhemolysis in sickle cell disease attributable to anti-Fy3...
- Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse modelMaxime Desmarets
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Blood 114:2315-22. 2009..Cellular immunization to mHAs is neither monitored nor managed by current transfusion medicine practice; however, the current data suggest that mHAs on RBCs may represent an unappreciated and significant consequence of RBC transfusion...
- Early packed red blood cell transfusion and acute respiratory distress syndrome after traumaOnuma Chaiwat
Department of Anesthesiology, University of Washington School of Medicine, Seattle, Washington 98195 6540, USA
Anesthesiology 110:351-60. 2009..Transfusion of packed red blood cells (PRBCs) is a risk factor for acute respiratory distress syndrome (ARDS) in trauma patients. Yet, there is a paucity of information regarding the risk of ARDS with incremental PRBCs exposure...
- The cost-effectiveness of treatment with erythropoietin compared to red blood cell transfusions for patients with chemotherapy induced anaemia: a Markov modelSixten Borg
The Swedish Institute for Health Economics IHE, Lund, Sweden
Acta Oncol 47:1009-17. 2008..It is generally accepted that symptomatic anaemia should be corrected. Treatment options include red blood cell transfusion (RBCT), erythropoietin (EPO) administration or a combination of both...
- Clinical outcomes of ABO-incompatible RBC transfusionsKim A Janatpour
Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento 95817, USA
Am J Clin Pathol 129:276-81. 2008..Prompt recognition and discontinuation of the transfusion are critical because transfusing less ABO-incompatible blood may minimize signs and symptoms and may prevent death...
- The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantationZejing Wang
Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
Br J Haematol 149:101-10. 2010..ABO incompatibility did not affect nonmyeloablative HCT outcomes...
- Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblingsF Weissinger
Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, USA
Blood 98:3584-8. 2001....
- Transfusion of red cells in hematopoietic stem cell transplantation (TRIST): study protocol for a randomized controlled trialJason Tay
The Ottawa Hospital Blood and Marrow Programme, The Ottawa Hospital, Ottowa, Canada
Trials 12:207. 2011....
- Adequacy of physician documentation of red blood cell transfusion and correlation with assessment of transfusion appropriatenessMark T Friedman
Department of Pathology and Laboratory Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
Arch Pathol Lab Med 130:474-9. 2006..A major function of the hospital transfusion service is to assess the appropriateness of blood transfusion. Inadequate documentation of transfusions may hamper this assessment process...
- Which groups of patients are transfused? A study of red cell usage in London and southeast EnglandS J Stanworth
National Blood Service London and South East, Crescent Drive, Brentwood, Essex CM15 8DP, UK
Vox Sang 83:352-7. 2002..The aim of this survey was to identify major specialty users of blood to target for audit of transfusion practice with a view to minimizing inappropriate use and to support planning of blood supply needs for the future...
- Association of RBC transfusion with mortality in patients with acute lung injuryGiora Netzer
Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, MSTF Bldg, Room 800, 685 W Baltimore St, Baltimore, MD 21201, USA
Chest 132:1116-23. 2007..RBC transfusion has been associated with increased morbidity and mortality in a variety of clinical settings. We assessed the effect of RBC transfusion on in-hospital mortality in patients with acute lung injury (ALI)...
- Liberal or restrictive transfusion in high-risk patients after hip surgeryJeffrey L Carson
Division of General Internal Medicine, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
N Engl J Med 365:2453-62. 2011..We conducted a randomized trial to determine whether a higher threshold for blood transfusion would improve recovery in patients who had undergone surgery for hip fracture...
- The association of perioperative red blood cell transfusions and decreased long-term survival after cardiac surgeryStephen D Surgenor
Dartmouth Hitchcock Medical Center, Department of Surgery, 1 Medical Center Drive Lebanon, NH 03756, USA
Anesth Analg 108:1741-6. 2009..Exposure to red blood cell (RBC) transfusions has been associated with increased mortality after cardiac surgery. We examined long-term survival for cardiac surgical patients who received one or two RBC units during index hospitalization...
- Appropriateness of allogeneic red blood cell transfusion: the international consensus conference on transfusion outcomesAryeh Shander
Department of Anesthesiology, Critical Care and Hyperbaric Medicine, Englewood Hospital and Medical Center, 350 Engle Street, Englewood, NJ 07631, USA
Transfus Med Rev 25:232-246.e53. 2011..In addition, the large number of scenarios in which RBC transfusions were rated as uncertain can serve as a road map to identify areas in need of further investigation...
- Efficacy of allogeneic red blood cell transfusionsJean Louis Vincent
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
Best Pract Res Clin Anaesthesiol 21:209-19. 2007..In this article, several key factors influencing the systemic and regional efficacy of blood transfusion will be reviewed...
- Impact of safety concerns and regulatory changes on the usage of erythropoiesis-stimulating agents and RBC transfusionsSaroj Vadhan-Raj
Department of Sarcoma Medical Oncology, Section of Cytokines and Supportive Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Oncologist 15:1359-69. 2010..Safety concerns raised in the recent oncology trials with erythropoiesis-stimulating agents (ESAs) have led to regulatory restrictions on their use. We wished to determine the impact of these changes on the use of ESAs and RBC transfusions...
- RBC transfusion requirements after allogeneic marrow transplantation: impact of the before-transplant Hb level on transfusion and early survivalAnargyros Xenocostas
Hematology Division, London Health Sciences Center, University of Western Ontario, Canada
Transfusion 43:373-82. 2003....
- A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantationKathryn E Webert
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Transfusion 48:81-91. 2008..Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia...
- Reduced hemoglobin on day of peripheral blood progenitor cell collection is associated with low graft content of vascular progenitors and increased toxicity after autologous hematopoietic stem cell transplantationGurnaam Kasbia
Division of Hematology, Blood and Marrow Transplant Program, The Ottawa Hospital, Ottawa Health Research Institute, Ottawa, Ontario, Canada
Transfusion 48:2421-8. 2008..The aim was to determine the importance of pretransplant anemia on toxicity and red blood cell (RBC) transfusion requirements after autologous HSCT...
- Fully Biodegradable Polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-bPAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2010..Significant additional advantages will be a tremendous cost savings to the health care system in reduced operating costs, as well as enormous job creation and economic stimulus. ..
- High-Tc susceptometer to monitor transfusional iron overload (NSR device)Gary M Brittenham; Fiscal Year: 2012..abstract_text> ..
- Hematopoietic Cell Transplantation and Iron OverloadH Joachim Deeg; Fiscal Year: 2013....
- Transfusion Trigger Trial in Coronary Artery Disease: A Pilot StudyJEFFREY LEE CARSON; Fiscal Year: 2010....
- FOCUSJEFFREY LEE CARSON; Fiscal Year: 2011..abstract_text> ..
- FOCUS Data Coordinating CenterMichael L Terrin; Fiscal Year: 2010..abstract_text> ..
- Mechanisms underlying the harmful effects of stored red blood cell transfusionsELDAD ARIE HOD; Fiscal Year: 2013....
- Role of RAGE in Transfusion Mediated Acute Lung InjuryNILAM S MANGALMURTI; Fiscal Year: 2013....
- Comparative Effectiveness: Erythropoietic Stimulating Agents in Treatment of MDSAmy J Davidoff; Fiscal Year: 2010..We will examine the characteristics of Medicare beneficiaries with MDS, patterns of treatment, safety and effectiveness of ESA use, and costs of care. ..
- Harmful effects of red blood cell transfusions are mediated by ironSteven L Spitalnik; Fiscal Year: 2013..This new information will help identify ways to improve the safety of RBC transfusions in hospitalized patients. ..
- Feasibility of Expert System to Promote African American Blood Donation for SCDMark L Robbins; Fiscal Year: 2010....
- NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTINGJohn D Roback; Fiscal Year: 2010..We anticipate that commercialization of the AEGIS will reduce the incidence of incompatible transfusions and thus improve transfusion outcomes and patient safety. ..
- Adverse effects of RBC transfusions: A unifying hypothesisJohn D Roback; Fiscal Year: 2012..However, transfusions are associated with adverse effects. These studies will seek to determine why adverse outcomes happen after transfusion, and develop ways to improve blood collection and storage to minimize these outcomes. ..
- Properties of stored RBCs: minimization of immune and vascular reactivityPhilip J Norris; Fiscal Year: 2012..Importantly, the proposal will validate the knowledge gained and systems developed in a human clinical trial and will evaluate methods of preventing harmful effects of RBC storage using in vitro systems. ..
- TRANSFUSION BIOLOGY AND MEDICINEPearl Toy; Fiscal Year: 2005..The ultimate goals of this program are to make optimal use of blood products, to evaluate and possibly modify the immune effects and understand and possibly stimulate blood production so as to reduce transfusion needs. ..
- The Role of Nitric Oxide in Red Blood Cell TransfusionKYLA BENNETT; Fiscal Year: 2009..Delineating the importance and function of NO in transfusion is pivotal to this process. It is expected to advance both conventional transfusion practice as well as successful production of synthetic blood products. ..
- VIRALLY INACTIVATED HUMAN RED CELLS FOR TRANSFUSIONAndrei Purmal; Fiscal Year: 2004..The results of these studies will set the stage for pivotal clinical trials to be carried out during the five year time-frame of this proposal. ..
- A PLASMA COLLECTION DEVICE FOR RED CELL CONSERVATIONMichael Jaeger; Fiscal Year: 2000..abstract_text> ..
- Erythrocyte Transfusion in Acute Lung Injury During SepsisNilam Mangalmurti; Fiscal Year: 2009..We have developed an in vivo murine model whereby purified erythrocyte transfusion promotes neutrophilic accumulation in the lungs...
- VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBCStephen Wagner; Fiscal Year: 2004..abstract_text> ..
- Pediatric Clinical Research Scholar Program - WashingtonNaomi Luban; Fiscal Year: 2007..abstract_text> ..
- IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSIONLoren Fast; Fiscal Year: 2002..abstract_text> ..
- Tolerance to Carbohydrate Antigens in TransplantationDavid Cooper; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Induction of Immunological Tolerance for Gene TherapyJAMES ZIMRING; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- CD8 + CD75s + regulatory T cells in anti-tumor immunityJAMES ZIMRING; Fiscal Year: 2007..These aims propose to investigate the role that negative regulatory T cells play in the establishment of immunological tolerance to tumor antigens and the fashion in which their elimination can result in tumor rejection. ..
- Alloimmunization to mHAs by RBC TransfusionJAMES ZIMRING; Fiscal Year: 2007..By analyzing transfusion patients at Emory, we will determine the extent to which females receiving leukoreduced RBC from male donors are immunized to H-Y antigens. [unreadable] [unreadable] [unreadable]..
- Physician Training Program in Neonatal BiologyJohn Widness; Fiscal Year: 2007..With NIH support beyond that which the investigators currently enjoy, the investigators will be able to significantly enhance the research training experiences they offer their postdoctoral physician trainees in neonatal medicine. ..
- Blood Filter to Remove Pathogen Inactivation CompoundJohn Chapman; Fiscal Year: 2005..3. Construct "proof of concept" prototype filters meeting defined performance specifications. ..
- The role of Ach in CD8+ Cytolytic T cell developmentJAMES ZIMRING; Fiscal Year: 2005..abstract_text> ..
- Thromboregulation to Prevent Thrombotic MicroangiopathyDavid Cooper; Fiscal Year: 2008..It is anticipated that these approaches will abrogate the development of TM and allow long-term survival of pig organs in baboons. ..
- Selective depletion of alloreactive T cells in BMTJAMES ZIMRING; Fiscal Year: 2005..In keeping with the stated purpose of this RFA, these studies represent the "development and application of cell engineering methods to predictably induce tolerance..." ..
- INDICES OF BIOTIN NUTRITIONDonald Mock; Fiscal Year: 2001..4) Whether biotin deficiency of similar severity to that observed either early or late in human gestation causes increased rates of fetal malformation in the mouse. 5) The enzyme(s) responsible for biotin beta-oxidation. ..
- MIDCAREER AWARD IN PATIENT ORIENTED OBSTETRIC RESEARCHDwight Rouse; Fiscal Year: 2004..Finally, the effectiveness of an intervention (how it would perform under conditions of actual clinical practice) is an attribute that, in many situations, is as important as its efficacy (how it performs under ideal conditions). ..
- Rapid quantitation of residual WBCs in filtered bloodJohn Roback; Fiscal Year: 2004....
- Nonhematopoietic Developmental Functions of EPOSandra Juul; Fiscal Year: 2004..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
- FOCUS Hip Fracture Transfusion Trial: Delirium and Other Cognitive OutcomesAnn L Gruber Baldini; Fiscal Year: 2010..This ancillary study examines whether transfusion helps prevent short-term (post- randomization) and long-term (30 day) changes in delirium. ..
- Modulation of Iron Deposition in SCD and Other HemoglobinopathiesELLIOTT P contact VICHINSKY; Fiscal Year: 2010....
- NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTINGJohn Roback; Fiscal Year: 2004..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..
- Aminocaproic Acid and Bleeding in Spinal SurgerySean Berenholtz; Fiscal Year: 2006..These projects and the career development plan described will build a foundation for a successful career as an independent investigator. ..
- Inducing Immune Tolerance with Receptor Modified T CellsTerrence Geiger; Fiscal Year: 2003..Together this information will provide a starting point for the application of GM-TCs to human immunologic conditions. ..
- ERYTHROCYTAPHERESIS TO LOWER IRON LOADING IN THALASSEMIAAlan Cohen; Fiscal Year: 2002....
- COST EFFECTIVENESS OF GENETIC SCREENING FOR COLON CANCERScott Ramsey; Fiscal Year: 2002....
- FACSVantage SE Sorting Flow CytometerJane Barker; Fiscal Year: 2002..Funds are requested to purchase the FACSVantage SE and the optional equipment for TJL's Flow Cytometry Service. This will provide a cost-effective way to fill an urgent need of TJL's principal investigators. ..
- VASCULAR BED SPECIFIC EXPRESSION OF A VWF TRANSGENEWILLIAM AIRD; Fiscal Year: 2001..Taken together, these studies should provide important information about the mechanisms of endothelial cell heterogeneity and vascular diversity. ..
- CARDIOPROTECTIVE EFFECT--NEW CHELATORS FOR THALASSEMIAChaim Hershko; Fiscal Year: 2001..abstract_text> ..
- Epo as a Rescue Agent for Perinatal Hypoxia-IschemiaSandra Juul; Fiscal Year: 2004....
- Chlamydia Infection as a Risk Factor for Cerebrovascula*Lori Styles; Fiscal Year: 2004..The data gained in this proposal would provide the preliminary data necessary to justify further clinical trials. ..
- Induction of Stable Chimerism for Sickle Cell AnemiaMark Walters; Fiscal Year: 2004..If successful, this novel approach will expand the availability of HCT for patients with clinically significant hemoglobinopathies. ..
- A Genetic Screening Policy Model for Colorectal CancerScott Ramsey; Fiscal Year: 2006..The model will incorporate QOL information from Aim 2, along with family history, clinical, and screening information from the Seattle CFR. ..
- Automated high-throughput detection anti-HLA antibodiesJohn Roback; Fiscal Year: 2006..This application proposes to develop a test that could be used to screen blood donors for these antibodies, thus preventing TRALI and improving patient outcomes. [unreadable] [unreadable] [unreadable]..
- Beta-Blockade Reduces Catabolism in Severely Injured Trauma PatientsJeffrey Johnson; Fiscal Year: 2007..This information will provide a platform from which to launch both basic science and clinical research into the (-adrenergic system and its effects on inflammation, catabolism, and functional outcome [unreadable] [unreadable]..
- PICU Nosocomial Infections: Epidemiology and OutcomesAlexis Elward; Fiscal Year: 2007....
- Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantationJohn Roback; Fiscal Year: 2006..unreadable] [unreadable]..
- Erythrocyte Nitrosothiol Flux and Vasoregulation in LungAllan Doctor; Fiscal Year: 2008..The candidate's long-term goal is to define the mechanism of NO traffic between regional vascular beds via the erythrocyte, and its role in the evolution of multiple organ failure in severe inflammatory states. ..
- VEGF, Transcriptional Networks and Vascular InflammationWilliam C Aird; Fiscal Year: 2010..abstract_text> ..
- ITEM BANKING AND CAT FOR QUALITY OF LIFE OUTCOMESDavid Cella; Fiscal Year: 2008..We will also monitor treatment/management changes, and evaluate acceptability of computer assessments and the perceived benefits of the recommendations. ..
- Northern California Consortium for Sickle Cell DiseaseMark Walters; Fiscal Year: 2008..abstract_text> ..
- MOLECULAR BASIS FOR TS TRANSLATIONAL REGULATIONEdward Chu; Fiscal Year: 2005..Moreover, these molecular-based studies may provide the rational basis for the development of novel therapeutic strategies for human cancer. ..
- Development of an ABO Incompatibility Stop Device (AISD)Christopher Hillyer; Fiscal Year: 2008..If the unit is not compatible, the transfusion is not allowed to proceed. This should stop all mistransfusion and the related deaths. [unreadable] [unreadable] [unreadable]..
- Cell Death and Clonal Survival in Myelodysplastic Syndr*H Deeg; Fiscal Year: 2008..To achieve these objectives, we must better understand the underlying mechanisms of MDS and thereby identify ways by which the disease process can be arrested, progression prevented, and the disease hopefully be cured. ..
- Acute Lung Injury after Trauma: Predicting its Onset and Identifying Novel RisksTIMOTHY WATKINS; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- E/BETA THALASSEMIA--NATURAL HISTORY & RESPONSE TO CHEMOElliott Vichinsky; Fiscal Year: 2002..In summary, if this study is successful, it will change the approach to Hb E/B worldwide and result in improved quality of life and decreased mortality. (End of Abstract) ..
- Eighth Cooley's Anemia SymposiumElliott Vichinsky; Fiscal Year: 2005....
- NOVEL THERAPEUTIC STRATEGIES IN MYELODYSPLASTIC SYNDROMEH Deeg; Fiscal Year: 2003..Optimization of therapy, in turn, should reduce morbidity and mortality associated with MDS and improve the quality of life of patients with MDS. ..