blood component transfusion

Summary

Summary: The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.

Top Publications

  1. ncbi Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    John B Holcomb
    United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Ann Surg 248:447-58. 2008
  2. pmc Enhanced cellular immunity in macaques following a novel peptide immunotherapy
    S Chea
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    J Virol 79:3748-57. 2005
  3. ncbi Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 105:2266-73. 2005
  4. ncbi Why do physicians request fresh frozen plasma?
    Walter Dzik
    Transfusion 44:1393-4. 2004
  5. ncbi Life-threatening adverse reaction followed by thrombocytopenia after passive transfusion of fresh frozen plasma containing anti-CD36 (Nak) isoantibody
    Katsuya Morishita
    Hokkaido Red Cross Blood Center, Sapporo, Japan
    Transfusion 45:803-6. 2005
  6. ncbi Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results
    Lorne L Holland
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Am J Clin Pathol 126:133-9. 2006
  7. pmc A linked donor-recipient study to evaluate parvovirus B19 transmission by blood component transfusion
    Steven H Kleinman
    Westat Inc, Rockville, MD, USA
    Blood 114:3677-83. 2009
  8. ncbi Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
    Gregory A Watson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:221-7; discussion 228-30. 2009
  9. ncbi Acute lung injury after blood transfusion in mechanically ventilated patients
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic Rochester, Minnesota 55905, USA
    Transfusion 44:1468-74. 2004
  10. ncbi Acute lung injury after ruptured abdominal aortic aneurysm repair: the effect of excluding donations from females from the production of fresh frozen plasma
    Stephen E Wright
    Department of Perioperative and Critical Care, Freeman Hospital, Newcastle upon Tyne, United Kingdom
    Crit Care Med 36:1796-802. 2008

Detail Information

Publications188 found, 100 shown here

  1. ncbi Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    John B Holcomb
    United States Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Ann Surg 248:447-58. 2008
    ....
  2. pmc Enhanced cellular immunity in macaques following a novel peptide immunotherapy
    S Chea
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    J Virol 79:3748-57. 2005
    ..De novo hepatitis C virus-specific CD4+- and CD8+-T-cell responses were generated in macaques by the same method. This simple technique holds promise for the immunotherapy of HIV and other chronic viral infections...
  3. ncbi Transfusion-related acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Blood 105:2266-73. 2005
    ..Prevention, treatment, and a proposed definition of TRALI, especially in the context of ALI, are also examined...
  4. ncbi Why do physicians request fresh frozen plasma?
    Walter Dzik
    Transfusion 44:1393-4. 2004
  5. ncbi Life-threatening adverse reaction followed by thrombocytopenia after passive transfusion of fresh frozen plasma containing anti-CD36 (Nak) isoantibody
    Katsuya Morishita
    Hokkaido Red Cross Blood Center, Sapporo, Japan
    Transfusion 45:803-6. 2005
    ..There are few reports, however, about the effects of passively transfused blood products containing this isoantibody on recipients...
  6. ncbi Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results
    Lorne L Holland
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Am J Clin Pathol 126:133-9. 2006
    ..7 showed a significant change in INR with FFP transfusion. Therefore, transfusion for patients not meeting current FFP guidelines does not reliably reduce the INR and exposes patients to unnecessary risk...
  7. pmc A linked donor-recipient study to evaluate parvovirus B19 transmission by blood component transfusion
    Steven H Kleinman
    Westat Inc, Rockville, MD, USA
    Blood 114:3677-83. 2009
    ..Although case reports of B19V transmission by blood component transfusion (as contrasted to manufactured plasma derivatives) are rare, no studies have systematically determined ..
  8. ncbi Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
    Gregory A Watson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:221-7; discussion 228-30. 2009
    ..We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications...
  9. ncbi Acute lung injury after blood transfusion in mechanically ventilated patients
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic Rochester, Minnesota 55905, USA
    Transfusion 44:1468-74. 2004
    ..We tested the hypotheses that storage age and specific type of blood products are associated with increased risk of ALI in mechanically ventilated patients...
  10. ncbi Acute lung injury after ruptured abdominal aortic aneurysm repair: the effect of excluding donations from females from the production of fresh frozen plasma
    Stephen E Wright
    Department of Perioperative and Critical Care, Freeman Hospital, Newcastle upon Tyne, United Kingdom
    Crit Care Med 36:1796-802. 2008
    ..We investigated whether the change to male fresh frozen plasma was associated with a change in the frequency of acute lung injury in these patients...
  11. pmc Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries
    Philip C Spinella
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 66:S69-76. 2009
    ..We hypothesized that warm fresh whole blood (WFWB) transfusion would be associated with improved survival in patients with trauma compared with those transfused only stored component therapy (CT)...
  12. ncbi Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography
    Jeffry L Kashuk
    Department of Surgery, Denver Health Medical Center, University of Colorado Denver, CO, USA
    Ann Surg 251:604-14. 2010
    ....
  13. ncbi Effect of blood products transfusion on the development of postinjury multiple organ failure
    Jeffrey L Johnson
    Department of Surgery, University of Colorado Denver, USA
    Arch Surg 145:973-7. 2010
    ..Transfusion of fresh frozen plasma (FFP) and platelets is independently associated with the development of multiple organ failure (MOF) in critically injured patients...
  14. ncbi Symptomatic parvovirus B19 infection caused by blood component transfusion
    Masahiro Satake
    Japanese Red Cross Central Blood Institute, Tokyo, Japan
    Transfusion 51:1887-95. 2011
    ..It has therefore been a matter of debate whether a universal B19V screening with an appropriate sensitivity is required...
  15. ncbi Fresh frozen plasma should be given earlier to patients requiring massive transfusion
    Ernest A Gonzalez
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas, USA
    J Trauma 62:112-9. 2007
    ..The hypothesis for this study is that our pre-intensive care unit (ICU) massive transfusion (MT) protocol does not adequately correct coagulopathy, and that early uncorrected coagulopathy is predictive of mortality...
  16. ncbi Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients
    Thomas M Scalea
    R Adams Cowley Shock Trauma Center, Division of Clinical and Outcomes Research, Department of Surgery, Anesthesiology, and Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann Surg 248:578-84. 2008
    ..Recent data from Iraq supporting early aggressive use of fresh frozen plasma (FFP) in a 1:1 ratio to packed red blood cells (PRBCs) has led many civilian trauma centers to adopt this resource intensive strategy...
  17. ncbi Impact of transfusion of fresh-frozen plasma and packed red blood cells in a 1:1 ratio on survival of emergency department patients with severe trauma
    Shahriar Zehtabchi
    Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    Acad Emerg Med 16:371-8. 2009
    ..This evidence-based emergency medicine (EBM) review evaluates the evidence regarding the impact of 1:1 ratio of FFP:PRBC transfusion on survival of emergency department (ED) patients with severe trauma...
  18. ncbi Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  19. ncbi Guidelines for irradiation of blood and blood components to prevent post-transfusion graft-vs.-host disease in Japan
    T Asai
    Division of Blood Transfusion, Chiba University Hospital, Chiba, Japan
    Transfus Med 10:315-20. 2000
    ..Also recommended was irradiation not only of blood within 72 h after collection but also of blood stored for 14 days. Reported PT-GVHD has diminished to a few cases in recent years...
  20. pmc A national study of plasma use in critical care: clinical indications, dose and effect on prothrombin time
    Simon J Stanworth
    Department of Haematology Transfusion Medicine, John Radcliffe Hospital, NHS Blood and Transplant Oxford Radcliffe Hospitals Trust, and University of Oxford, Osler Road, Headington, Oxford, OX3 9BQ, UK
    Crit Care 15:R108. 2011
    ....
  21. ncbi A massive transfusion protocol to decrease blood component use and costs
    Terence O'Keeffe
    Departments of Surgery, Division of Burn, Trauma, and Critical Care, University of Texas Southwestern Medical School, Dallas 75390, USA
    Arch Surg 143:686-90; discussion 690-1. 2008
    ..A massive transfusion protocol (MTP) decreases the use of blood components, as well as turnaround times, costs, and mortality...
  22. pmc Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury
    Sigune Peiniger
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Centre, Ostmerheimerstrasse 200, D 51109 Cologne, Germany
    Crit Care 15:R68. 2011
    ....
  23. ncbi Effect of early plasma transfusion on mortality in patients with ruptured abdominal aortic aneurysm
    Matthew W Mell
    Division of Vascular Surgery, Stanford University, Stanford, CA, USA
    Surgery 148:955-62. 2010
    ..The purpose of this study was to determine the effect of the PRBC:FFP ratio on mortality for patients with massive hemorrhage after ruptured abdominal aortic aneurysm (RAAA)...
  24. ncbi The use of fresh-frozen plasma in England: high levels of inappropriate use in adults and children
    Simon J Stanworth
    NHS Blood and Transplant Oxford Radcliffe Hospitals Trust and University of Oxford, Oxford, UK
    Transfusion 51:62-70. 2011
    ..Fresh-frozen plasma (FFP) is given to patients across a range of clinical settings, frequently in association with abnormalities of standard coagulation tests...
  25. ncbi Impact of plasma transfusion in trauma patients who do not require massive transfusion
    Kenji Inaba
    Division of Trauma and Surgical Critical Care, University of Southern California, 1200 N State Street, Los Angeles, CA 90033, USA
    J Am Coll Surg 210:957-65. 2010
    ..The aim of this study was to evaluate the impact of plasma administration in nonmassively transfused patients...
  26. ncbi Fresh frozen plasma and platelet transfusion for nonbleeding patients in the intensive care unit: benefit or harm?
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care Med 34:S170-3. 2006
    ..We searched the National Library of Medicine PubMed database as well as references of retrieved articles and summarized the current evidence for the use of FFP and platelet transfusions in critically ill patients...
  27. ncbi The effects of leukodepletion on the generation and removal of microvesicles and prion protein in blood components
    Pranee Krailadsiri
    National Blood Service England and North Wales, Scottish National Blood Transfusion Service, Bristol Institute for Transfusion Sciences, University of Edinburgh and University of Cambridge, United Kingdom
    Transfusion 46:407-17. 2006
    ..If LD causes microvesiculation of blood cells, however, potentially infectious membrane-associated prion could reach the final products...
  28. ncbi The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
    ..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
  29. ncbi Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival
    Oliver L Gunter
    Department of General Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Trauma 65:527-34. 2008
    ..The purpose of this study was to evaluate whether suggested blood product ratios yield superior survival rates...
  30. ncbi Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer?
    Jeffry L Kashuk
    Department of Surgery and Surgical Research, Denver Health Medical Center, Denver, Colorado 80204 4507, USA
    J Trauma 65:261-70; discussion 270-1. 2008
    ..Consequently, we reviewed our massive transfusion practices during a 5-year period to test the hypothesis that 1:1 FFP:RBC within the first 6 hours reduces life threatening coagulopathy...
  31. ncbi Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie
    M Maegele
    Department of Trauma and Orthopedic Surgery, and Institute for Research in Operative Medicine IFOM, University of Witten Herdecke, Cologne Merheim Medical Center CMMC, Cologne, Germany
    Vox Sang 95:112-9. 2008
    ..To test whether an acute transfusion practice of packed red blood cells (pRBC) : fresh-frozen plasma (FFP) 1 : 1 would be associated with reduced mortality in acute bleeding multiply injury...
  32. pmc The good use of plasma. A critical analysis of five international guidelines
    Alfonso Iorio
    Medicina Interna e Vascolare, Universita di Perugia, Italy
    Blood Transfus 6:18-24. 2008
    ..The aim of the present study was to analyse some of the existing guidelines on the good use of plasma, applying a scientifically validated method, as a preliminary step in the implementation of Regional guidelines...
  33. ncbi Should plasma be transfused prophylactically before invasive procedures?
    Lorne Holland
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    Curr Opin Hematol 13:447-51. 2006
    ..This review aims to analyze the most recent publications to either support or disprove such practice...
  34. ncbi Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma
    John R Hess
    Transfusion 46:685-6. 2006
  35. ncbi Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG)
    Pär I Johansson
    Transfusion Service, Department of Clinical Immunology, University of Copenhagen, Rigshospitalet 2034, Blegdamsvej 9, Copenhagen, Denmark
    Transfus Apher Sci 39:3-8. 2008
    ..01). In 8 patients damage control surgery was successful and 6 of these patients survived. The result indicates that an early balanced transfusion strategy maintains haemostatic competence in massively bleeding patients...
  36. ncbi Implementation of a blood irradiation program at a community cancer center
    G A Patton
    Montgomery Cancer Center, Montgomery, Alabama, USA
    Transfusion 41:1610-6. 2001
    ....
  37. pmc Transfusion medicine in trauma patients
    Sarah B Murthi
    University of Maryland School of Medicine, Baltimore, MD, USA
    Expert Rev Hematol 1:99-109. 2008
    ..This research is clarifying trauma system requirements for new blood products and blood-product usage patterns, but the inability to obtain informed consent from severely injured patients remains an obstacle to further research...
  38. ncbi A national clinical scenario-based survey of clinicians' attitudes towards fresh frozen plasma transfusion for critically ill patients
    D M Watson
    Better Blood Transfusion, Scottish National Blood Transfusion Service, Glasgow, UK
    Transfus Med 21:124-9. 2011
    ..Our aim was to describe ICU clinicians' beliefs and practice in relation to FFP treatment of non-bleeding coagulopathic critically ill patients...
  39. pmc The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score
    M A Borgman
    Children s Hospital, Boston, MA, USA
    Vox Sang 101:44-54. 2011
    ....
  40. ncbi Blood component use in critically ill patients
    M P Rao
    National Blood Service Brentwood Centre, Crescent Drive, Brentwood, Essex CM1 8DP, UK
    Anaesthesia 57:530-4. 2002
    ..This study showed that transfusion practice is consistent and that in general there does not seem to be an excessive use of blood components in critically ill patients...
  41. ncbi Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma center
    Christopher J Dente
    Department of Surgery, Grady Memorial Hospital and Emory University School of Medicine, Atlanta, Georgia, USA
    J Trauma 66:1616-24. 2009
    ....
  42. ncbi Gamma-irradiation of blood products following autologous stem cell transplantation: surveillance of the policy of 35 centers
    B Weiss
    Medizinische Klinik A, Klinikum Ludwigshafen GmbH, Bremserstrasse 79, 67063 Ludwigshafen Rhein, Germany
    Ann Hematol 83:44-9. 2004
    ..No center experienced cases of proofed TA-GVHD. Guidelines should be worked out concerning transfusion policy after autologous stem cell transplantation...
  43. ncbi Single hospital experience of TRALI
    Jonathan P Wallis
    Department of Hematology, Freeman Hospital, and the National Blood Service, Newcastle upon Tyne, UK
    Transfusion 43:1053-9. 2003
    ..TRALI is a serious adverse effect of blood transfusion. There is evidence that the condition is underrecognized and underreported...
  44. ncbi Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy
    Larisa Cervenakova
    Jerome H Holland Laboratory for the Biomedical Sciences, Red Cross, Rockville, MD 20855, USA
    Transfusion 43:1687-94. 2003
    ....
  45. ncbi Efficacy and tolerability of a pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiency
    Wolfhart Kreuz
    Department of Paediatrics, University of Frankfurt Main, Germany
    Transfus Apher Sci 32:247-53. 2005
    ..Substitution with pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiencies is efficient and generally well tolerated...
  46. ncbi Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma
    Lloyd Ketchum
    Walter Reed Army Institute of Research, 503 Robert Grant Avenue, MCR, Silver Spring, Maryland 20910, USA
    J Trauma 60:S51-8. 2006
    ..Guidelines for the use of non-RBC blood components in the early phase of trauma resuscitation are largely based on extensions of expert recommendations for general surgery...
  47. ncbi Pharmacokinetic properties of a pasteurised fibrinogen concentrate
    Wolfhart Kreuz
    Department of Paediatrics, University of Frankfurt Main, Germany
    Transfus Apher Sci 32:239-46. 2005
    ....
  48. ncbi Coagulopathy and blood component transfusion in trauma
    D R Spahn
    Department of Anaesthesiology, University Hospital Lausanne, Lausanne, Switzerland
    Br J Anaesth 95:130-9. 2005
    ....
  49. ncbi Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization
    Bryan A Cotton
    Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Trauma 64:1177-82; discussion 1182-3. 2008
    ....
  50. ncbi Population-based audit of fresh-frozen plasma transfusion practices
    Riikka Palo
    Finnish Red Cross Blood Service, Helsinki, Finland
    Transfusion 46:1921-5. 2006
    ..To improve transfusion practices, knowledge of current FFP use and regional, national, and international comparison is necessary...
  51. ncbi Transfusion practice in massively bleeding patients: time for a change?
    P I Johansson
    Department of Clinical Immunology, University Hospital of Copenhagen, Copenhagen, Denmark
    Vox Sang 89:92-6. 2005
    ..We identified some fatal cases where massively bleeding patients received inadequate transfusion therapy. The aim of this study was to review and evaluate the transfusion practice in acutely multitransfused patients...
  52. ncbi Unappreciated risk factors for transplant patients: HLA antibodies in blood components
    Robert A Bray
    Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, United States
    Hum Immunol 65:240-4. 2004
    ..This unappreciated frequency of HLA alloantibodies in blood components may pose a risk to transplant patients requiring transfusions by promoting allograft dysfunction or loss...
  53. ncbi Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations
    C Fenger-Eriksen
    Centre for Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital, Brendstrupgaardsvej, 8200 Aarhus N, Denmark
    Br J Anaesth 101:769-73. 2008
    ..We audited the effects of fibrinogen concentrate therapy on laboratory and clinical outcome in patients with massive haemorrhage...
  54. pmc Optimal use of blood in trauma patients
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Science Center, 6410 Fannin St, Suite 1100 Houston, TX 77030, USA
    Biologicals 38:72-7. 2010
    ..This review will address the issues raised above and describe recent trauma patient outcome data utilizing predetermined plasma:platelet:RBC transfusion ratios and an ongoing prospective observational trauma transfusion study...
  55. pmc Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study
    N Rahe-Meyer
    Department of Anaesthesiology, Hannover Medical School, Carl Neuberg Str 1, Hannover D 30625, Germany
    Br J Anaesth 102:785-92. 2009
    ..The aim was to compare haemostatic effects of conventional transfusion management and FIBTEM (thromboelastometry test)-guided fibrinogen concentrate administration...
  56. ncbi Hemostatic resuscitation during surgery improves survival in patients with traumatic-induced coagulopathy
    Juan C Duchesne
    Department of Surgery and Anesthesia, Tulane University School of Medicine, LA Trauma Critical Care, New Orleans, Louisiana 70112 2699, USA
    J Trauma 67:33-7; discussion 37-9. 2009
    ..We hypothesized that a survival benefit would occur when early hemostatic resuscitation was used intraoperatively after injury in patients with TIC...
  57. ncbi Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant
    D F O'Shaughnessy
    Southampton University Hospitals, Southampton, UK
    Br J Haematol 126:11-28. 2004
    ..FFP must be thawed using a technique that avoids risk of bacterial contamination. Plastic packs containing any of these plasma products are brittle in the frozen state and must be handled with care...
  58. ncbi Room for (performance) improvement: provider-related factors associated with poor outcomes in massive transfusion
    Bryan A Cotton
    Department of Surgery, Center for Translational Injury Research, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 67:1004-12. 2009
    ..The purpose of this study was to identify the incidence and impact of MT protocol noncompliance and to intervene in provider-related events associated with poor compliance and outcomes...
  59. ncbi Emergency department blood transfusion predicts early massive transfusion and early blood component requirement
    Timothy C Nunez
    Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    Transfusion 50:1914-20. 2010
    ..The purpose of this study was to evaluate the ability of uncrossmatched transfusions in the emergency department (ED) to predict early (< 6 hr) massive transfusion (MT) of red blood cells (RBCs) and blood components...
  60. ncbi Fresh frozen plasma transfusion in critically ill patients
    Francois Lauzier
    Department of Medicine, Division of Critical Care, Centre Hospitalier Universitaire Affilié de Québec, Hopital de l Enfant Jesus, Quebec, Canada
    Crit Care Med 35:1655-9. 2007
    ..The objectives of this study were to evaluate the consistency of Canadian guidelines for FFP administration to critically ill patients and to examine factors associated with inappropriate FFP transfusions...
  61. ncbi Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation
    Asher Hirshberg
    Trauma Modeling Center and Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Trauma 54:454-63. 2003
    ..Current massive transfusion guidelines are derived from washout equations that may not apply to bleeding trauma patients. Our aim was to analyze these guidelines using a computer simulation...
  62. ncbi Blood component transfusion in primary coronary artery bypass surgery in Kuwait
    Fahad Al-Shammari
    Department of Cardiac Surgery, Chest Diseases Hospital, Kuwait
    Med Princ Pract 14:83-6. 2005
    ..The aims of this study were to determine the rate of blood product transfusion, associated perioperative factors and cost of such blood product transfusion in primary coronary artery bypass surgery (CABG)...
  63. ncbi Transfusion from male-only versus female donors in critically ill recipients of high plasma volume components
    Ognjen Gajic
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Crit Care Med 35:1645-8. 2007
    ..The objective of this study was to evaluate the effect of transfusing components from male-only vs. female donors on development of ALI, gas exchange, and outcome in critically ill patients...
  64. ncbi Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities
    Omar I Abdel-Wahab
    Department of Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Transfusion 46:1279-85. 2006
    ....
  65. ncbi Evaluation of a reporting system for bacterial contamination of blood components in the United States
    V R Roth
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Transfusion 41:1486-92. 2001
    ..A national effort to assess the frequency of blood component bacterial contamination associated with transfusion reaction (the BaCon Study) was initiated to better estimate their occurrence...
  66. pmc The impact of donor type and ABO incompatibility on transfusion requirements after nonmyeloablative haematopoietic cell transplantation
    Zejing Wang
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, USA
    Br J Haematol 149:101-10. 2010
    ..ABO incompatibility did not affect nonmyeloablative HCT outcomes...
  67. ncbi Fibrinogen concentrates for bleeding trauma patients: what is the evidence?
    M A S Meyer
    Section for Transfusion Medicine, Capital Regional Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Vox Sang 101:185-90. 2011
    ..Fibrinogen concentrates could potentially lessen or replace the need for fresh frozen plasma and/or platelet transfusions...
  68. ncbi Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60 years?
    Juan C Duchesne
    Division of Trauma Critical Care Surgery, Department of Surgery, Tulane University School of Medicine New Orleans, Louisiana 70112 2699, USA
    J Trauma 65:272-6; discussion 276-8. 2008
    ..We hypothesize a similar improvement in mortality in civilian trauma patients that require massive transfusion and are treated with a FFP to PRBC ratio closer to 1:1...
  69. ncbi Inactivation of viral and prion pathogens by gamma-irradiation under conditions that maintain the integrity of human albumin
    S I Miekka
    Clearant, Inc, Gaithersburg, Maryland, USA
    Vox Sang 84:36-44. 2003
    ..Our objective was to determine if gamma-irradiation can inactivate viral or prion infectivity without damaging a protein biotherapeutically...
  70. pmc Comparison of acute non-haemolytic transfusion reactions in female and male patients receiving female or male blood components
    S Imoto
    Hyogo Red Cross Blood Center, Kobe, Japan
    Transfus Med 17:455-65. 2007
    ..Although the anti-HLA antibodies were detected more frequently in females than males, no significant association of ANHTRs including TRALI with gender, not only for patients, but also for donors, could be shown in this study...
  71. ncbi Transfusion-related acute lung injury surveillance (2003-2005) and the potential impact of the selective use of plasma from male donors in the American Red Cross
    Anne F Eder
    Biomedical Services, National Headquarters, American Red Cross, Washington, DC 20006, USA
    Transfusion 47:599-607. 2007
    ....
  72. ncbi Fresh-frozen plasma transfusion in patients with mild coagulation abnormalities at a large Canadian transfusion center
    Calvino K Cheng
    Transfusion 47:748; author reply 749. 2007
  73. ncbi Proteomics of blood-based therapeutics: a promising tool for quality assurance in transfusion medicine
    Thomas Thiele
    Institute of Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    BioDrugs 21:179-93. 2007
    ..Optimized preparation procedures and storage conditions will reduce the risk of protein alterations, which in turn may contribute to better recovery, reduced exposure to allogeneic proteins, and increased transfusion safety...
  74. ncbi Transfusion protocol for implantation and explantation of cardiac devices in an academic medical center
    Angela N Bartley
    Department of Pathology, University of Arizona Health Sciences Center, Tucson, Arizona, USA
    ASAIO J 53:320-3. 2007
    ..Our data do not support the need for preparation of cryoprecipitate before implantation or explantation...
  75. ncbi Fresh-frozen plasma transfusion in patients with mild coagulation abnormalities at a large Canadian transfusion center
    Dana V Devine
    Transfusion 47:749. 2007
  76. ncbi Modern plasma fractionation
    Thierry Burnouf
    Human Plasma Product Services, Lille, France
    Transfus Med Rev 21:101-17. 2007
    ..In a regulated and professional environment, fractionated plasma products manufactured by modern processes are certainly among the lowest-risk therapeutic biological products in use today...
  77. ncbi High-volume transfusion from male-only versus female donor plasma and hypoxemia in the critically ill
    Christopher C Silliman
    Crit Care Med 35:1775. 2007
  78. ncbi Acute lung injury after blood product transfusion: are the times changing?
    Mark R Looney
    Crit Care Med 36:1968-70. 2008
  79. ncbi Photochemical inactivation with amotosalen and long-wavelength ultraviolet light of Plasmodium and Babesia in platelet and plasma components
    Philippe Grellier
    Biologie Fonctionnelle des Protozoaires, Museum national d histoire naturelle, Paris, France
    Transfusion 48:1676-84. 2008
    ....
  80. ncbi Toward reducing perioperative transfusions
    Joseph A Joyce
    Wesley Long Community Hospital, Division of the Moses Cone Health System, Greensboro, NC, USA
    AANA J 76:131-7. 2008
    ..Achieving this goal requires a concerted effort by surgeons, perioperative nurses, and anesthesia providers...
  81. ncbi Estimating the pathogen safety of manufactured human plasma products: application to fibrin sealants and to thrombin
    Bernard Horowitz
    Horowitz Consultants, LLC, Key Biscayne, Florida, USA
    Transfusion 48:1739-53. 2008
    ....
  82. ncbi [Report on notifications pursuant to Section 21 German Transfusion Act for 2005 and 2006]
    B Haschberger
    Paul Ehrlich Institut, Bundesamt für Sera und Impfstoffe, Langen, Germany
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 51:353-72. 2008
    ..The reported number of haemophilia patients has to be regarded as considerably too low. With the upcoming introduction of a German Haemophilia Register, an improvement of the data base is intended...
  83. doi Re: Transfusion protocol for implantation and explantation of cardiac devices in an Academic Medical Center
    Emily N Gray
    ASAIO J 54:138; author reply 138-40. 2008
  84. ncbi Predictors of blood product use in orthotopic liver transplantation using the piggyback hepatectomy technique
    R S Mangus
    Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, Indiana 46202 5250, USA
    Transplant Proc 39:3207-13. 2007
    ..Piggyback hepatectomy (PGB) is a technique increasingly utilized in OLT to avoid veno-venous bypass and vena cava clamping. This study evaluated the factors associated with blood loss and blood product requirement in PGB...
  85. ncbi Anticoagulation, bleeding and blood transfusion practices in Australasian cardiac surgical practice
    D J Daly
    Department of Anaesthesia and Perioperative Medicine, Cardiothoracic Unit, The Alfred Hospital, Commercial Road, Melbourne, Victoria, Australia
    Anaesth Intensive Care 35:760-8. 2007
    ..Many patients presenting for surgery receive antiplatelet and/or antifibrinolytic therapy, yet the subsequent benefits and risks remain unclear...
  86. ncbi Update on transfusion medicine
    Aryeh Shander
    Department of Anesthesiology and Critical Care and Hyperbaric Medicine and the New Jersey Institute for the Advancement of Bloodless Medicine and Surgery, Englewood Hospital and Medical Center, Englewood, New Jersey 07631, USA
    Pharmacotherapy 27:57S-68S. 2007
    ..The benefits, risks, and several ongoing controversies that relate to the appropriateness and safety of blood product use are also summarized...
  87. ncbi A comparison of complication rates based on published haemovigilance data
    O Flesland
    Blood Bank, Asker and Baerum Hospital, 83, 1309 Rud, Norway
    Intensive Care Med 33:S17-21. 2007
    ..g. if the countries differ significantly in products used. The current study focuses on immunological transfusion complications, especially TRALI, as published in haemovigilance reports from Denmark, Norway, Sweden and the UK...
  88. ncbi [Diagnosis and transfusion algorithm for the management of perioperative coagulopathy]
    Toshiharu Azma
    Department of Anesthesiology, Faculty of Medicine, Saitama Medical University, Saitama 350 0495
    Masui 57:1095-102. 2008
    ..The transfusion algorithms based on causal diagnosis of coagulopathy optimize the risk/ benefit ratio of perioperative transfusion therapy...
  89. ncbi Plasma and plasma products in the treatment of massive haemorrhage
    Wendy N Erber
    Department of Haematology, Addenbrooke s Hospital, Addenbrooke s NHS Trust, Hills Road, Cambridge CB2 2QQ, UK
    Best Pract Res Clin Haematol 19:97-112. 2006
    ..The physiology and management of the coagulation disturbance using plasma products in the massive haemorrhage of specific clinical situations are described...
  90. ncbi Manufacture and composition of fresh frozen plasma and virus-inactivated therapeutic plasma preparations: correlation between composition and therapeutic efficacy
    Peter Hellstern
    Institute of Hemostaseology and Transfusion Medicine, City Hospital Ludwigshafen, Bremserstrasse 79, D 67063, Ludwigshafen, Germany
    Thromb Res 107:S3-8. 2002
    ..By way of contrast, there is a lack of data about the clinical efficacy and tolerance of MBP compared to FFP...
  91. ncbi Indications for plasma in massive transfusion
    Peter Hellstern
    Institute of Hemostaseology and Transfusion Medicine, City Hospital, Bremserstrasse 79, D 67063, Ludwigshafen am Rhein, Germany
    Thromb Res 107:S19-22. 2002
    ..The turnaround time for obtaining laboratory results and for readying plasma for transfusion must be taken into particular consideration in cases of rapid blood loss...
  92. ncbi [Blood management in surgery--an analysis]
    J Erhard
    Klinik für Chirurgie Viszeral und Gefässchirurgie, Evangelisches und Johanniter Klinikum Duisburg Dinslaken Oberhausen gGmbH, Dinslaken
    Zentralbl Chir 128:481-6. 2003
    ..The key points to stay within the low range of the number of transfusions are to develop a specific peri-, intra-, and postoperative strategy according to patient, disease, and expected procedure. The surgical aspects are discussed...
  93. ncbi Practical guidelines for the clinical use of plasma
    Peter Hellstern
    Institute of Hemostaseology and Transfusion Medicine, City Hospital Ludwigshafen, Bremserstrasse 79, D 67063, Ludwigshafen, Germany
    Thromb Res 107:S53-7. 2002
    ..Side effects resulting from the administration of plasma are rare but have to be considered...
  94. ncbi Use of blood products in sepsis: an evidence-based review
    Janice L Zimmerman
    Baylor College of Medicine, Houston, TX, USA
    Crit Care Med 32:S542-7. 2004
    ....
  95. ncbi Pump priming in heart surgery in infants
    Marilyn S Hamilton
    N Engl J Med 352:731. 2005
  96. ncbi Automated collection of blood components: their storage and transfusion
    G Rock
    Department of Pathology and Laboratory Medicine, Ottawa Hospital and Canadian Blood Services, Ottawa, Ontario, Canada
    Transfus Med 13:219-25. 2003
    ..The platelets have good in vivo recovery, as shown by the CCI values. An added advantage is that the TRIMA machine can be used in hospitals to generate components in times of shortage without the need for a component's laboratory...
  97. ncbi [Blood product transfusion in the neonatal period]
    F Arnaud
    Service de neonatalogie, Faculte de Medecine, Universite de la Mediterranee, Hopital de la Conception, AP HM, Marseille, France
    Transfus Clin Biol 12:336-41. 2005
    ..However, a better understanding of the indications of blood transfusion and the provision of practice guidelines may justify a re-evaluation of prophylactic strategies for anemia of prematurity...
  98. ncbi [Report on Notifications pursuant to Section 21 German Transfusion Act for 2001 and 2002]
    B Haschberger
    Paul Ehrlich Institut, Langen
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 48:99-119. 2005
    ..However, a statement on the supply situation cannot be yet made anyway, due to the missing notifications on the consumption figures...
  99. ncbi Guidelines for assessing appropriateness of pediatric transfusion
    Susan D Roseff
    Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0662, USA
    Transfusion 42:1398-413. 2002
  100. ncbi Acute transient leukopenia as a sign of TRALI
    Marisa B Marques
    Am J Hematol 80:90-1. 2005
  101. ncbi Off-pump coronary artery bypass grafting in a patient with congenital factor V deficiency: report of a case
    Goichi Yotsumoto
    Second Department of Surgery, Kagoshima University, Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Surg Today 35:142-4. 2005
    ..We herein describe a patient with severe factor V deficiency who underwent successful off-pump coronary artery bypass grafting with a transfusion of fresh-frozen plasma...

Research Grants23

  1. Automated high-throughput detection anti-HLA antibodies
    John Roback; Fiscal Year: 2006
    ..This application proposes to develop a test that could be used to screen blood donors for these antibodies, thus preventing TRALI and improving patient outcomes. [unreadable] [unreadable] [unreadable]..
  2. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2005
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  3. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  4. Rapid quantitation of residual WBCs in filtered blood
    John Roback; Fiscal Year: 2004
    ....
  5. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2004
    ..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..
  6. CONFERENCE ON HIV PATHOGENESIS
    Michael Lederman; Fiscal Year: 2005
    ....
  7. Endothelial Stem Cells in Tumor Vasculature
    PAMPEE YOUNG; Fiscal Year: 2005
    ..I hope that significant contributions to the study of stem cells will result in the establishment of a successful, independent research program. ..
  8. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002
    ..abstract_text> ..
  9. 5-Year Survival Following Injury in Geriatric Patients
    Laura Criddle; Fiscal Year: 2006
    ..Contribution: This foundational study will provide basic information about the survival patterns of injured elders as a basis for the development of interventions to improve geriatric survival. [unreadable] [unreadable] [unreadable]..
  10. Case CFAR Meeting: HIV Pathogenesis
    Michael Lederman; Fiscal Year: 2006
    ..Presentation sessions will be Cellular Restrictions Factors; Latency; Protection from HIV Infection; Immune Pathogenesis; and Vaccines. ..
  11. Topical Immune modulatory strategies to prevent HIV transmission
    Michael Lederman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. 2007 Case CFAR Annual Spring Conference
    Michael Lederman; Fiscal Year: 2007
    ..The Case CFAR is proactive in its efforts to ensure inclusion of minority and female researchers in[unreadable] all aspects of Conference planning and attendance. ..
  13. Lyso-PCs activate PMNs and endothelium via PKC
    CHRISTOPHER SILLIMAN; Fiscal Year: 2006
    ..Completion of these specific aims will likely result in targets for in vitro, and possibly clinical, intervention to develop methods to inhibit or to attenuate the effects of these lipids and ultimately make transfusion safer. ..
  14. Identifying functional regulatory elements in RNA
    SCOTT TENENBAUM; Fiscal Year: 2005
    ..The aim of this project is to develop novel tiling array based ribonomic profiling methods including high-throughput RBP foot-printing, which will in turn, facilitate the comprehensive mapping of RNA regulatory elements. ..
  15. CANCER AND LEUKEMIA GROUP B
    MARGARET KESSINGER; Fiscal Year: 2002
    ..During the coming grant period, UNMC will continue to make major contributions to group accrual, group science and group administration. Additional financial support will facilitate and strengthen these contributions. ..
  16. Immune Mechanisms and HIV Disease Pathogenesis
    Michael Lederman; Fiscal Year: 2004
    ..The proposal's specific request is for support to increase participation in the Conference by female and/or minority researchers and students. ..
  17. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  18. SUBCLINICAL CMV INFECTION AFTER MARROW TRANSPLANTATION
    William Nichols; Fiscal Year: 2004
    ..This award will support my first step towards obtaining my long-term career goal, which is to be a proficient clinical investigator for infections in the immunocompromised host. ..
  19. Inducing Immune Tolerance with Receptor Modified T Cells
    Terrence Geiger; Fiscal Year: 2003
    ..Together this information will provide a starting point for the application of GM-TCs to human immunologic conditions. ..
  20. PCR Screening for CMV in Umbilical Cord Blood Stem Cells
    Christopher Hillyer; Fiscal Year: 2003
    ....
  21. TRANSFUSION TRANSMISSION OF CELL-ASSOCIATED INFECTIONS
    Christopher Hillyer; Fiscal Year: 2003
    ..He predicts that allogeneic leukocyte interactions mediate reactivation of MCMV in the recipient and that g IFN inhibits this process. ..
  22. "Development of a Laboratory Test for TTP"
    Christopher Hillyer; Fiscal Year: 2003
    ..abstract_text> ..
  23. Development of an ABO Incompatibility Stop Device (AISD)
    Christopher Hillyer; Fiscal Year: 2008
    ..If the unit is not compatible, the transfusion is not allowed to proceed. This should stop all mistransfusion and the related deaths. [unreadable] [unreadable] [unreadable]..