Genomes and Genes
Summary: The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications425 found, 100 shown here
- The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control studyAlexander P J Vlaar
Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
Blood 117:4218-25. 2011..In conclusion, the incidence of TRALI is high in cardiac surgery patients and associated with adverse outcome. Our results suggest that cardiac surgery patients may benefit from exclusion of blood products containing HLA/HNA antibodies...
- A predictive model for massive transfusion in combat casualty patientsDaniel F McLaughlin
United States Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
J Trauma 64:S57-63; discussion S63. 2008..We postulated that evaluation of clinical variables routinely assessed upon admission would allow identification of these patients for earlier, more effective intervention...
- Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigationsD Frith
Trauma Clinical Academic Unit, The Royal London Hospital, Bart s and The London School of Medicine and Dentistry, Queen Mary University London, UK
J Thromb Haemost 8:1919-25. 2010..Acute traumatic coagulopathy (ATC) is an impairment of hemostasis that occurs early after injury and is associated with a 4-fold higher mortality, increased transfusion requirements and organ failure...
- Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their preventionEleftherios C Vamvakas
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
Blood 113:3406-17. 2009As the risks of allogeneic blood transfusion (ABT)-transmitted viruses were reduced to exceedingly low levels in the US, transfusion-related acute lung injury (TRALI), hemolytic transfusion reactions (HTRs), and transfusion-associated ..
- Transmission of Leishmania infantum via blood transfusion in dogs: potential for infection and importance of clinical factorsEloisa de Freitas
Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Avda Antonio Carlos, 6627, Bairro Pampulha, Belo Horizonte, CEP 31 270 901 Minas Gerais, Brazil
Vet Parasitol 137:159-67. 2006b>Blood transfusion is an important routine practice in veterinary medicine that generally involves the use of whole blood...
- Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trialHaleema Shakur
Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Lancet 376:23-32. 2010..We assessed the effects of early administration of a short course of tranexamic acid on death, vascular occlusive events, and the receipt of blood transfusion in trauma patients.
- Operative blood loss, blood transfusion, and 30-day mortality in older patients after major noncardiac surgeryWen Chih Wu
Department of Community Health, Brown University, Providence Veterans Affairs Medical Center, Providence, RI, USA
Ann Surg 252:11-7. 2010..Anemia and operative blood loss are common in the elderly, but evidence is lacking on whether intraoperative blood transfusions can reduce the risk of postoperative death...
- Global epidemiology of hepatitis C virus infectionColin W Shepard
Epidemiology Branch, Division of Viral Hepatitis, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
Lancet Infect Dis 5:558-67. 2005....
- Anemia and patient blood management in hip and knee surgery: a systematic review of the literatureDonat R Spahn
Institute of Anesthesiology, University Hospital and University of Zurich, Zurich, Switzerland
Anesthesiology 113:482-95. 2010..Perioperative anemia was associated with a blood transfusion rate of 45 +/- 25% and 44 +/- 15%, postoperative infections, poorer physical functioning and recovery, and ..
- Viremic profiles in asymptomatic and symptomatic chikungunya fever: a blood transfusion threat?Hatsadee Appassakij
Department of Pathology and the Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand Bureau of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
Transfusion 53:2567-74. 2013..However, the viremic profiles of asymptomatic chikungunya patients, the major determinant of the transfusion risk, are unknown...
- The coagulopathy of trauma: a review of mechanismsJohn R Hess
Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
J Trauma 65:748-54. 2008..Coagulopathy associated with severe injury complicates the control of bleeding and is associated with increased morbidity and mortality in trauma patients. The causes and mechanisms are multiple and yet to be clearly defined...
- Early evaluation of acute traumatic coagulopathy by thrombelastographyRoger C Carroll
Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn 37920, USA
Transl Res 154:34-9. 2009..001 by chi-square testing). PlateletMapping assays correlated with the need for blood transfusion. The abnormal TEG System parameters correlated with fatality. These coagulopathies were already evident OS...
- MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patientsJohn C Wood
Department of Pediatrics, Children s Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027 0034, USA
Blood 106:1460-5. 2005..Both R2 and R2* can accurately measure hepatic iron concentration throughout the clinically relevant range of HIC with appropriate MRI acquisition techniques...
- Transfusion-related acute lung injury in the critically ill: prospective nested case-control studyOgnjen Gajic
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Respir Crit Care Med 176:886-91. 2007..Several transfusion characteristics have been postulated as risk factors for TRALI, but the evidence is limited to retrospective studies...
- Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control studyAlexander P J Vlaar
Intensive Care Department, Academic Medical Center, Amsterdam, The Netherlands
Crit Care Med 38:771-8. 2010..To determine the incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of critically ill patients...
- Transfusion-related acute lung injury: report of a clinical look-back investigationPatricia M Kopko
Sacramento Blood Centers, 1625 Stockton Blvd, Sacramento, CA 95816, USA
JAMA 287:1968-71. 2002..TRALI is the third leading cause of transfusion-related mortality, but it is probably underdiagnosed and underreported...
- Prion diseases are efficiently transmitted by blood transfusion in sheepFiona Houston
Neuropathogenesis Division, Roslin Institute, Compton, United Kingdom
Blood 112:4739-45. 2008..BSE) epidemic, led to concerns about the potential risk of iatrogenic transmission of disease by blood transfusion and the introduction of costly control measures to protect blood supplies...
- Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromesSunil V Rao
Duke Clinical Research Institute, Durham, NC 27715, USA
JAMA 292:1555-62. 2004It is unclear if blood transfusion in anemic patients with acute coronary syndromes is associated with improved survival.
- Reinfusion of drained blood as an alternative to homologous blood transfusion after total knee replacementA Sinha
Department of Orthopaedics and Traumatology, St Richard s Hospital, Chichester, UK
Int Orthop 25:257-9. 2001..There was no significant difference in the postoperative haemoglobin values between the two groups. None of the patients developed any adverse reactions after reinfusion...
- Specificities of leucocyte alloantibodies in transfusion-related acute lung injury and results of leucocyte antibody screening of blood donorsA Reil
Leucocyte Immunology Laboratory, Blood Service West of the German Red Cross, Hagen, Germany
Vox Sang 95:313-7. 2008..Antibody-mediated transfusion-related acute lung injury (TRALI) is an important cause of transfusion-associated morbidity and death. Preventive strategies are currently a matter of debate...
- Hepatitis B virus transmission by blood transfusion during 4 years of individual-donation nucleic acid testing in South Africa: estimated and observed window period riskMarion Vermeulen
Donation Testing Department, South African National Blood Service SANBS, Roodepoort, South Africa
Transfusion 52:880-92. 2012..Over 4 years, 149 hepatitis B surface antigen-negative acute-phase HBV NAT-positive donations were identified (1:19,608). The lookback program identified one probable HBV transmission...
- Blood still kills: six strategies to further reduce allogeneic blood transfusion-related mortalityEleftherios C Vamvakas
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
Transfus Med Rev 24:77-124. 2010After reviewing the relative frequency of the causes of allogeneic blood transfusion-related mortality in the United States today, we present 6 possible strategies for further reducing such transfusion-related mortality...
- Transfusion and pulmonary morbidity after cardiac surgeryColleen Koch
Department of Cardiothoracic Anesthesia, Cleveland Clinic, Cleveland, Ohio 44195, USA
Ann Thorac Surg 88:1410-8. 2009..Our objective was to determine the prevalence of pulmonary morbidity related to transfusion and whether TRALI consensus-criteria are applicable to cardiac surgery...
- Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reductionDaniel J Riskin
Department of Surgery, Stanford School of Medicine, Stanford, CA, USA
J Am Coll Surg 209:198-205. 2009..Our purpose was to evaluate mortality and blood product use in the context of a newly initiated massive transfusion protocol (MTP)...
- Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trialsYoan K Kagoma
Applied Science and Engineering, University of Toronto, Toronto, Ontario, Canada
Thromb Res 123:687-96. 2009..To address this issue we performed a systematic review of randomized trials describing the use of tranexamic acid, epsilon aminocaproic acid, or aprotinin administration in the perioperative setting...
- A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuriesAmy J Plotkin
Pittsburgh Tissue Engineering Initiative, Pittsburgh, Pennsylvania, USA
J Trauma 64:S64-8. 2008..We hypothesized that TEG data would aid in defining the coagulopathy of trauma in patients with penetrating traumatic injuries...
- Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision makingLuca Malcovati
Division of Hematology, IRCCS, Policlinico San Matteo, 27100 Pavia, Italy
J Clin Oncol 23:7594-603. 2005....
- Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapyHerbert Schöchl
Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
Crit Care 15:R83. 2011....
- The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveriesBrian T Bateman
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Anesth Analg 110:1368-73. 2010..In this study, we sought to (1) define trends in the incidence of postpartum hemorrhage (PPH), and (2) elucidate the contemporary epidemiology of PPH focusing on risk factors and maternal outcomes related to this delivery complication...
- Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complicationsBryan A Cotton
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA
J Trauma 66:41-8; discussion 48-9. 2009..The purpose of this study was to determine whether MT protocols are associated with increased organ failure and complications...
- Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhageCarl J Hauser
Department of Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02216, USA
J Trauma 69:489-500. 2010..Traumatic coagulopathy contributes to early death by exsanguination and late death in multiple organ failure. Recombinant Factor VIIa (rFVIIa, NovoSeven) is a procoagulant that might limit bleeding and improve trauma outcomes...
- Obstetric hemorrhageC McLintock
National Women s Health, Auckland City Hospital, Auckland, New Zealand
J Thromb Haemost 9:1441-51. 2011..However, in women with uterine atony who have ongoing bleeding in spite of an adequate transfusion, it may be reasonable to consider a trial of rFVIIa before a hysterectomy...
- Transmission of West Nile virus from an organ donor to four transplant recipientsMartha Iwamoto
Epidemic Intelligence Service, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta 30333, USA
N Engl J Med 348:2196-203. 2003..In August 2002, fever and mental-status changes developed in recipients of organs from a common donor. Transmission of West Nile virus through organ transplantation was suspected...
- Transfusion-transmitted hepatitis B virus infectionDaniel Candotti
National Health Service Blood and Transplant, Cambridge Blood Centre, Long Road, Cambridge CB2 2PT, UK
J Hepatol 51:798-809. 2009..Pre-transfusion testing and post-transfusion long-term follow-up of recipients, and molecular analysis of the virus infecting both donor and recipient are critical to definitively incriminate transfusion in the transmission of HBV...
- External financial aid to blood transfusion services in sub-Saharan Africa: a need for reflectionFereydoun Ala
University of Cambridge, Cambridge, United Kingdom
PLoS Med 9:e1001309. 2012Jean-Pierre Allain and colleagues argue that, while unintended, the foreign aid provided for blood transfusion services in sub-Saharan Africa has resulted in serious negative outcomes, which requires reflection and rethinking.
- Transmission of sporadic Creutzfeldt-Jakob disease by blood transfusion: risk factor or possible biasesMaria Puopolo
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
Transfusion 51:1556-66. 2011..The occurrence of transfusion transmissions of variant Creutzfeldt-Jakob disease (CJD) cases has reawakened attention to the possible similar risk posed by other forms of CJD...
- Transfusion associated necrotizing enterocolitis: a meta-analysis of observational dataAdel Mohamed
Department of Pediatrics, Mount Sinai Hospital, Toronto, Canada
Pediatrics 129:529-40. 2012..Our objective was to systematically review and meta-analyze the association between transfusion and NEC (TANEC), identify predictors of TANEC, and the assess impact of TANEC on outcomes...
- How important is transfusion avoidance in 2013?Iain C Macdougall
Department of Renal Medicine, King s College Hospital, London SE5 9RS, UK
Nephrol Dial Transplant 28:1092-9. 2013..The aim of this review is to reassess how important transfusion avoidance is in 2013, and whether we should still have the same concerns about HLA sensitization that we had 20 years ago...
- Intravenous iron supplementation for the treatment of chemotherapy-induced anaemia - systematic review and meta-analysis of randomised controlled trialsAnat Gafter-Gvili
Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Israel net
Acta Oncol 52:18-29. 2013..Current guidelines are inconclusive regarding intravenous (IV) iron for treatment of chemotherapy-induced anaemia (CIA)...
- First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort studyKlaus Görlinger
Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
Anesthesiology 115:1179-91. 2011b>Blood transfusion is associated with increased morbidity and mortality...
- Iron overload in non-transfusion-dependent thalassemia: a clinical perspectiveKhaled M Musallam
IRCCS Cà Granda Foundation Maggiore Policlinico Hospital, University of Milan, Milan, Italy
Blood Rev 26:S16-9. 2012..Therefore, direct measurement of LIC is recommended with chelation therapy as indicated...
- Red blood cell transfusion is associated with increased rebleeding in patients with nonvariceal upper gastrointestinal bleedingS Restellini
Department of Medical Specialities, Division of Gastroenterology and Hepatology, Geneva s University Hospitals and University of Geneva, Geneva, Switzerland
Aliment Pharmacol Ther 37:316-22. 2013..Studies in other critically ill cohorts suggest associations between transfusions and adverse patient outcomes...
- Transfusion-transmitted malaria in countries where malaria is endemic: a review of the literature from sub-Saharan AfricaAlex K Owusu-Ofori
Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana
Clin Infect Dis 51:1192-8. 2010....
- Transfusion-transmitted malaria in GhanaAlex K Owusu-Ofori
Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana
Clin Infect Dis 56:1735-41. 2013..Although the burden of TTM in malaria-endemic countries is unknown, it is recommended that all donated blood is screened for malaria parasites. This study aimed to establish the incidence of TTM and identify a suitable screening test...
- Autotransfusion drains in total knee replacement. Are they alternatives to homologous transfusion?T Abuzakuk
Royal National Orthopaedic Hospital, Brockley Hill Stanmore, Middlesex HA7 4LP, UK
Int Orthop 31:235-9. 2007..The use of the autologous transfusion system (Bellovac) proved to be safe but failed to reduce the need for postoperative homologous blood transfusion following uncomplicated total knee arthroplasty.
- Overview of revised measures to prevent malaria transmission by blood transfusion in FranceO Garraud
Etablissement Français du Sang, Saint Denis, France
Vox Sang 95:226-31. 2008..Plasmodial transmission by blood donation is rare in non-endemic countries, but a very serious complication of blood transfusion. The French national blood service (Etablissement Français du Sang and Centre de Transfusion sanguine des ..
- The pathogenesis of transfusion-related acute lung injury (TRALI)Jürgen Bux
DRK Blood Service West of the German Red Cross, Hagen, Germany
Br J Haematol 136:788-99. 2007..This model comprises the priming of neutrophils and/or endothelium by the patient's co-morbidity, neutrophil and/or endothelial cell activation by the transfused blood component, and the severity of the TRALI reaction...
- Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trialSusan M Goobie
Department of Anesthesia, Perioperative, and Pain Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Anesthesiology 114:862-71. 2011..The primary and secondary outcome variables were reduction in perioperative blood loss and reduction in blood transfusion, respectively.
- MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in miceRichard T Strait
Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Exp Med 208:2525-44. 2011..lung injury (TRALI), a form of noncardiogenic pulmonary edema that develops during or within 6 h after a blood transfusion, is the most frequent cause of transfusion-associated death in the United States...
- Quality of assessment of randomized controlled trials in blood conservation after joint arthroplastyRajrishi Sharma
Department of Surgery, Division of Orthopaedic Surgery, McMaster University, Hamilton, Ontario, Canada
J Arthroplasty 26:909-13. 2011b>Blood transfusion after joint arthroplasty occurs in up to two thirds of patients. We conducted a systematic review of the literature to determine the methodological quality of published randomized controlled trials (RCTs)...
- HCV routes of transmission: what goes around comes aroundMiriam J Alter
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA
Semin Liver Dis 31:340-6. 2011..Ongoing monitoring of the epidemiology of HCV infection is crucial for preventing future infections...
- Acute respiratory distress syndrome in blunt trauma: identification of independent risk factorsPreston R Miller
Department of Surgery, The University of Tennessee Health Science Center, Memphis 38163, USA
Am Surg 68:845-50; discussion 850-1. 2002..Improvement in understanding of which patients are actually at risk may allow for advances in treatment as well as prevention in the future...
- Cost minimization analysis of preoperative erythropoietin vs autologous and allogeneic blood donation in total joint arthroplastyWilliam Scott Green
Department of Orthopedic Surgery, University of California San Francisco, San Francisco, California 94143, USA
J Arthroplasty 25:93-6. 2010Autologous blood donation and erythropoietin (EPO) have been shown to be effective in reducing allogeneic blood transfusion, but the cost-effectiveness of these interventions remains unclear...
- Uncertainty in the tail of the variant Creutzfeldt-Jakob disease epidemic in the UKTini Garske
Department of Infectious Disease Epidemiology, Medical Research Council Centre of Outbreak Analysis and Modelling, Imperial College London, London, United Kingdom
PLoS ONE 5:e15626. 2010..past food-borne transmissions occurring in previously mostly unaffected genotypes and to transmissions via blood transfusion in all genotypes...
- Dutch orthopedic blood management surveys 2002 and 2007: an increasing use of blood-saving measuresWieger Geert Horstmann
Department of Orthopedic Surgery, Kennemer Gasthuis Haarlem, Boerhaavelaan 22, 2035 RC Haarlem, The Netherlands
Arch Orthop Trauma Surg 130:55-9. 2010..Hip and knee arthroplasties are frequently complicated by the need for allogeneic blood transfusions. The surveys were developed to assess the use of blood-saving measures in orthopedic surgery in the Netherlands in 2002 and 2007...
- Increasing trends in atonic postpartum haemorrhage in Ireland: an 11-year population-based cohort studyJ E Lutomski
National Perinatal Epidemiology Centre, Cork University Maternity Hospital, Wilton, Cork, Ireland
BJOG 119:306-14. 2012To derive nationally representative incidence rates of postpartum haemorrhage (PPH), and to investigate trends associated with method of delivery, blood transfusion and morbidly adherent placenta (accreta, percreta and increta).
- Maternal obesity and risk of postpartum hemorrhageMarie Blomberg
Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
Obstet Gynecol 118:561-8. 2011..To estimate whether maternal obesity was associated with an increased risk for postpartum hemorrhage more than 1,000 mL and whether there was an association between maternal obesity and causes of postpartum hemorrhage and mode of delivery...
- Impact of individual-donation nucleic acid testing on risk of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus transmission by blood transfusion in South AfricaMarion Vermeulen
South African National Blood Service SANBS, Roodepoort, South Africa
Transfusion 49:1115-25. 2009..At the same time the use of ethnic origin to prioritize the transfusion of blood according to a hierarchy of residual risk was discontinued...
- Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overloadJohn Paul Carpenter
Cardiovascular MR Unit, Royal Brompton Hospital, London, London, UK
J Cardiovasc Magn Reson 12:24. 2010..We aimed to define reference ranges for right ventricular (RV) volumes, ejection fraction (EF) in thalassemia major patients (TM) without myocardial iron overload...
- The risk of transfusion-transmitted infections in sub-Saharan AfricaSudha Jayaraman
Department of Surgery and Global Health Sciences, University of California at San Francisco, San Francisco, California, USA
Transfusion 50:433-42. 2010..This study estimates the risks of acquiring human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV) from a single unit of blood in sub-Saharan Africa...
- Reappraising the concept of massive transfusion in traumaSimon J Stanworth
NHS Blood and Transplant, Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK
Crit Care 14:R239. 2010..We also examined whether the concept was useful in that early prediction of massive transfusion requirements could allow early activation of blood bank protocols...
- Transfusion-related acute lung injury (TRALI): current concepts and misconceptionsChristopher C Silliman
Research Department, Bonfils Blood Center, Denver CO 80230, USA
Blood Rev 23:245-55. 2009..This review will detail the pathophysiology of TRALI including recent pre-clinical data, provide insight into newer areas of research, and critically assess current practices to decrease it prevalence and to make transfusion safer...
- Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trialsS J Stanworth
NBS, Level 2, John Radcliffe Hospital, Headington, Oxford, UK
Br J Haematol 126:139-52. 2004..Trials of modified FFP (e.g. pathogen inactivated) are of questionable value when there is little evidence that the standard product is an effective treatment...
- Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overloadAli Taher
Department of Internal Medicine, Haematology Oncology Division, American University of Beirut, Medical Centre, Beirut, Lebanon
Br J Haematol 147:752-9. 2009..This has important implications for patients who are heavily transfused and may require higher doses to reduce body iron burden...
- Anemia, tumor hypoxemia, and the cancer patientJohn Varlotto
Department of Radiation Oncology, Boston VA Medical Center, Boston, MA 02130, USA
Int J Radiat Oncol Biol Phys 63:25-36. 2005..To review the impact of anemia/tumor hypoxemia on the quality of life and survival in cancer patients, and to assess the problems associated with the correction of this difficulty...
- Tranexamic acid in total knee replacement: a systematic review and meta-analysisS Alshryda
The James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, UK
J Bone Joint Surg Br 93:1577-85. 2011..TXA led to a significant reduction in the proportion of patients requiring blood transfusion (risk ratio (RR) 2.56, 95% confidence interval (CI) 2.1 to 3.1, p < 0...
- Elevated liver iron concentration is a marker of increased morbidity in patients with β thalassemia intermediaKhaled M Musallam
Department of Internal Medicine, Division of Hematology and Oncology, American University of Beirut Medical Center, Beirut, Lebanon
Haematologica 96:1605-12. 2011..This study evaluates whether iron overload in patients with β thalassemia intermedia is associated with morbidity...
- Changing trends in hepatitis C infection over the past 50 years in JapanHobyung Chung
Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
Intervirology 53:39-43. 2010..1930s among injecting drug users (IDUs) during and after World War II or through medical procedures such as blood transfusion and use of contaminated syringes...
- Systematic review and meta-analysis of the use of tranexamic acid in total hip replacementM Sukeik
Department of Trauma and Orthopaedics, University College London Hospital, 235 Euston Road, London NW1 2BU, UK
J Bone Joint Surg Br 93:39-46. 2011..TXA led to a significant reduction in the proportion of patients requiring allogeneic blood transfusion (risk difference -0.20, 95% CI -0.29 to -0.11, p < 0.00001, I(2) 15%)...
- Autologous blood transfusion in total knee replacement surgeryD Thomas
Morriston Hospital, Swansea NHS Trust, UK
Br J Anaesth 86:669-73. 2001..036). Total patient costs were Pound Sterling 113 greater in the autotransfusion group. We conclude that in this type of surgery post-operative cell salvage is a safe and effective method for reducing allogeneic blood use...
- Residual risk of transfusion-transmitted viral infections in Shenzhen, China, 2001 through 2004Guifang Shang
Blood and Tissue Unit, Therapeutic Goods Administration, Woden ACT, Australia
Transfusion 47:529-39. 2007..Such estimates are an essential prerequisite to monitoring and improving transfusion safety as well as supporting evidence based assessment of the value of implementing new screening interventions...
- Malaria and blood transfusionA D Kitchen
National Blood Service, London, UK
Vox Sang 90:77-84. 2006The transmission of malaria by blood transfusion was one of the first recorded incidents of transfusion-transmitted infection...
- Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonographyR J Adams
Department of Neurology, Medical College of Georgia, Augusta 30912 3200, USA
N Engl J Med 339:5-11. 1998..We used transcranial Doppler ultrasonography to identify children with sickle cell anemia who were at high risk for stroke and then randomly assigned them to receive standard care or transfusions to prevent a first stroke...
- Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodiesEiko Shimada
Transfusion Information Department, The Japanese Red Cross Central Blood Center, Tokyo, Japan
Transfusion 42:766-73. 2002..Haptoglobin deficiency therefore might be a risk factor for NHTRs...
- Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2Ross Davenport
Trauma Clinical Academic Unit, Blizard Institute of Cell and Molecular Science, The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
J Trauma 70:90-5; discussion 95-6. 2011..There is controversy over the optimal FFP:PRBC ratio with respect to outcomes, and their hemostatic effects have not been studied. We report preliminary findings on the effects of different FFP:PRBC ratios on coagulation...
- Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factorsChristopher C Silliman
Bonfils Blood Center and the Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
Blood 101:454-62. 2003..TRALI, like the acute respiratory distress syndrome, may be a 2-event phenomenon with both recipient predisposition and factors in the stored units playing major roles...
- Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysisMarcello Tonelli
Department of Medicine, University of Alberta, Edmonton
CMAJ 180:E62-71. 2009..However, their safety and effectiveness is controversial. We did a systematic review of the clinical efficacy and harms of these agents in adults with anemia related to cancer or chemotherapy...
- Risk of recurrent stroke in children with sickle cell disease receiving blood transfusion therapy for at least five years after initial strokeDouglas J Scothorn
University of Texas Southwestern Medical Center, Dallas, TX, USA
J Pediatr 140:348-54. 2002....
- Management of major blood loss: an updateP I Johansson
Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Acta Anaesthesiol Scand 54:1039-49. 2010..The aim of the goal-directed therapy should be to maintain a normal haemostatic competence until surgical haemostasis is achieved, as this appears to be associated with reduced mortality...
- Transfusion-related acute lung injury: from bedside to bench and backBeth H Shaz
New York Blood Center, 310 East 67th St, New York, NY 10065, USA
Blood 117:1463-71. 2011..Thus, steps to mitigate TRALI are in place, but a complete mechanistic understanding of the pathogenesis of TRALI and of which patients are at highest risk remains to be elucidated...
- Transfusion-related acute lung injury (TRALI): a clinical review with emphasis on the critically illAlexander B Benson
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, School of Medicine University of Colorado Denver, Aurora, CO 80230, USA
Br J Haematol 147:431-43. 2009..Avoidance including male-only transfusion practises, the use of leucoreduced components, fresher blood/blood components and solvent detergent plasma are also discussed...
- Ten years of hemovigilance reports of transfusion-related acute lung injury in the United Kingdom and the impact of preferential use of male donor plasmaCatherine E Chapman
NHS Blood and Transplant, Newcastle upon Tyne, UK
Transfusion 49:440-52. 2009..From late 2003, the National Blood Service provided 80 to 90 percent of fresh-frozen plasma (FFP) and plasma for platelet (PLT) pools from male donors...
- Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injuryMark R Looney
Cardiovascular Research Institute, Department of Medicine, UCSF, San Francisco, California, USA
J Clin Invest 116:1615-23. 2006..In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors...
- Surviving blood loss without blood transfusion in a swine poly-trauma modelHasan B Alam
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Surgery 146:325-33. 2009..This study investigated whether VPA treatment would improve survival in a clinically relevant large animal model of poly-trauma/hemorrhagic shock, and whether the protective effects are executed through the Akt survival pathway...
- Transfusion in sub-Saharan Africa: does a Western model fit?Stephen P Field
Welsh Blood Service, Pontyclun, Wales, UK
J Clin Pathol 60:1073-5. 2007....
- The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacementEdna Zohar
Department of Anesthesiology and Intensive Care, Meir Hospital, Kfar Saba 44281, Israel
Anesth Analg 99:1679-83, table of contents. 2004..Because oral drug administration is simple and does not require specific infusion equipment, the authors suggest that oral TA is a superior blood-sparing strategy compared with IV drug administration...
- A comparison of aprotinin and lysine analogues in high-risk cardiac surgeryDean A Fergusson
Ottawa Health Research Institute, Ottawa, Canada
N Engl J Med 358:2319-31. 2008..We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences...
- Blood group terminology 2004: from the International Society of Blood Transfusion committee on terminology for red cell surface antigensG L Daniels
Bristol Institute for Transfusion Sciences, Bristol, UK
Vox Sang 87:304-16. 2004
- Recipients of blood from a donor with multiple HLA antibodies: a lookback study of transfusion-related acute lung injuryPearl Toy
Blood Bank, Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California 94143 0100, USA
Transfusion 44:1683-8. 2004..The effects of transfusion of HLA antibodies to patients with corresponding antigens are not well known...
- Left ventricular diastolic function compared with T2* cardiovascular magnetic resonance for early detection of myocardial iron overload in thalassemia majorMark A Westwood
Cardiovascular MR Unit, Royal Brompton Hospital and Imperial College, Sydney Street, London SW3 6NP, UK
J Magn Reson Imaging 22:229-33. 2005..To compare left ventricular (LV) diastolic function with myocardial iron levels in beta thalassemia major (TM) patients, using cardiovascular magnetic resonance (CMR)...
- Haemoglobin E beta thalassaemia in Sri LankaA Premawardhena
National Thalassaemia Centre, General Hospital, Kurunegala, Sri Lanka
Lancet 366:1467-70. 2005..Age-related changes in the pattern of adaptation to anaemia suggest that different and more cost-effective approaches to management should be explored...
- Ischemic preconditioning may be transferable via whole blood transfusion: preliminary evidenceE W Dickson
University of Massachusetts Medical Center Department of Emergency Medicine, Worcester, Massachusetts 01655, USA
J Thromb Thrombolysis 8:123-9. 1999..designed to test the hypothesis that ischemic preconditioning can be transferred between animals via whole blood transfusion. Preconditioning at a distance refers to the reduction in myocardial infarct size seen when coronary artery ..
- Reducing noninfectious risks of blood transfusionBrian M Gilliss
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0624, USA
Anesthesiology 115:635-49. 2011....
- Effect of blood transfusion on long-term survival after cardiac operationMilo C Engoren
Department of Anesthesiology, St Vincent Mercy Medical Center, and Medical College of Ohio, Toledo 43608, USA
Ann Thorac Surg 74:1180-6. 2002..Because we could not find any studies evaluating the effects of transfusion on long-term survival after cardiac operation, we sought to determine these effects...
- Activity-based costs of blood transfusions in surgical patients at four hospitalsAryeh Shander
The Institute for Patient Blood Management and Bloodless Medicine at Englewood Hospital and Medical Center, Englewood, New Jersey, USA
Transfusion 50:753-65. 2010..Determining the cost of supplying patients with blood transfusions requires an in-depth examination of the complex array of activities surrounding the decision to transfuse...
- Transfusion-transmitted malaria: case report of asymptomatic donor harboring Plasmodium malariaePatricia Scuracchio
Banco de Sangue de Sao Paulo, Sao Paulo, SP, Brasil
Rev Inst Med Trop Sao Paulo 53:55-9. 2011..vivax ELISA reactive. All sera were P. falciparum ELISA negative. This case suggests the need of reviewing donor selection criteria and deferral strategies to prevent possible cases of transfusion-transmitted malaria...
- Retrospective analysis of blood transfusion recipients: evidence for post-transfusion hepatitis EV A Arankalle
Hepatitis Division, National Institute of Virology, Indian Council of Medical Research, Pune, India
Vox Sang 79:72-4. 2000..This retrospective study was to reassess the extent of post-transfusion hepatitis E among transfusion recipients, investigated in 1982...
- Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is appliedJuan C Alvarez
Department of Anesthesiology, University Hospital of Mar, Barcelona, Spain
Transfusion 48:519-25. 2008..The objective of this study was to assess the effectiveness of tranexamic acid to reduce transfusions in total knee replacement even when a blood conservation program is applied...
- Plasma and lipids from stored platelets cause acute lung injury in an animal modelChristopher C Silliman
Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80123, USA
Transfusion 43:633-40. 2003..We hypothesize that lipids generated during storage of PLTs cause TRALI in a two-event animal model...
- Perioperative parenteral tranexamic acid in liver tumor resection: a prospective randomized trial toward a "blood transfusion"-free hepatectomyCheng Chung Wu
Department of Surgery, Taichung Veterans General Hospital, and Department of Surgery, Chung Shan Medical University, Taichung, Taiwan
Ann Surg 243:173-80. 2006To examine the feasibility of a real "blood transfusion"-free hepatectomy in a large group of patients with liver tumors.
- Transfusion-related acute lung injury: a reviewMark R Looney
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143 0130, USA
Chest 126:249-58. 2004..Treatment is supportive, with a prognosis substantially better than most causes of clinical acute lung injury...
- POLYMER-COATED RED BLOOD CELL FOR SICKLE CELL DISEASETIMOTHY FISHER; Fiscal Year: 2003..acute complications of sickle cell disease (SCD), and the recent "STOP" study has demonstrated that chronic blood transfusion can prevent stroke in high-risk SCD children, transfusion in SCD has associated problems: 1) high ..
- Mechanism of HTLV-1 activation of the SRF pathway.Maureen Shuh; Fiscal Year: 2006..abstract_text> ..
- Aminocaproic Acid and Bleeding in Spinal SurgerySean Berenholtz; Fiscal Year: 2006..to quality improvement in the intensive care unit, with an emphasis on evaluating alternatives to allogeneic blood transfusion in critically ill patients...
- A QTL for fetal hemoglobin and F cells on chromosome 8qSwee Thein; Fiscal Year: 2003..The discovery of these factors may also suggest new approaches for therapeutic augmentation of fetal hemoglobin production in patients with SCD and beta thalassemia. ..
- Prevention of Complications in ThalassemiaElliott P Vichinsky; Fiscal Year: 2011..Pathogens are transmitted by blood transfusion, and altered host immunity from hypersplenism and iron overload contribute to the morbidity...
- Iron-mediated vascular disease in sickle cell disease.John C Wood; Fiscal Year: 2010..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
- Enhanced iron removal with peptide linked chelators targeted to ferritinElizabeth C Theil; Fiscal Year: 2010....
- Molecular Biology of Human Erythrocyte Alpha SpectrinPatrick G Gallagher; Fiscal Year: 2013..Some people require surgery or blood transfusions to treat the anemia. This application studies the what, why, and how of abnormalities of the lining of the red blood cell that cause the anemia. ..
- VEGF Regulation of Hepatic Erythropoietin SynthesisCalvin Kuo; Fiscal Year: 2009....
- Stem Cell Based Therapy For Radiation Induced Gastrointestinal SyndromeChandan Guha; Fiscal Year: 2010..g., blood transfusion for hemorrhage or bone marrow transplantation for cytoablative damage...
- Analysis of the leukemic stem cell niche in chronic myeloid leukemiaDANIELA SANDRA KRAUSE; Fiscal Year: 2013..dedicating at least 75% of my time to basic research and 25% of my time to clinical work and teaching in a blood transfusion and/or coagulation service...
- Pathogenesis of Oxidative Stress in Chagas DiseaseNisha Jain Garg; Fiscal Year: 2013..The zoonotic presence of parasite and increased population mobility, transmission through blood transfusion, congenital infection and organ transplantation has, in recent years, increased the human cases of Chagas in ..
- Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African AmericansELIZABETH GROOMS NESMITH; Fiscal Year: 2010..Participants will be excluded for blood transfusion within last 2 weeks, hypertension (BP >140/90 mm/Hg), infection (CRP >10mg/L), uncontrolled diabetes (..
- BIOENGINEERING DESIGN OF ARTIFICIAL BLOODMarcos Intaglietta; Fiscal Year: 2011..abstract_text> ..
- High-Tc susceptometer to monitor transfusional iron overload (NSR device)Gary M Brittenham; Fiscal Year: 2012..abstract_text> ..
- Accelerated Biologic Aging and Risk for Sepsis and Organ Failure Following TraumaELIZABETH GROOMS NESMITH; Fiscal Year: 2012..Participants will be excluded for 1) blood transfusion or infection <2 weeks prior to admission;2) steroid, NSAID, or salicylate use for >1 month prior to ..
- SYNTHESES AND CELLULAR STUDIES OF NEW PHOTOSENSITIZERS FOR MEDICAL APPLICATIONSKevin M Smith; Fiscal Year: 2013..design and development of better and more effective PDT photosensitizers for use in cancer, cardiovascular, blood transfusion, bone marrow purging, and spongiform encephalopathy areas of medicine...
- Harmful effects of transfusion of older stored red cells: iron and inflammationSteven L Spitalnik; Fiscal Year: 2012..The insights gained from completing this proposal will have an immediate impact on the current practice of blood transfusion and will provide the foundation for developing rationally-designed approaches to improve the quality of ..
- FOCUSJEFFREY LEE CARSON; Fiscal Year: 2011..Hgb levels above 10 g/dl improves patient outcome as compared to a more conservative strategy that withholds blood transfusion until the patient develops symptoms of anemia...
- Targeted delivery of osteoinductive molecules to biologic HA in bone graftsJennifer L Bain; Fiscal Year: 2012..By developing a method of anchoring these important proteins back to this commercially available bone we hope to increase the regenerative capacity of allograft bone comparable to the level of autogenous bone. ..
- Geographically robust rapid assay for T. cruzi infectionSYAMAL X RAYCHAUDHURI; Fiscal Year: 2010..In addition, number of cases of Chagas disease incidence in the USA is increasing mainly through blood transfusion from donors of Central America and Mexico origins where Chagas disease is highly endemic...
- Transfusion Induced BMT RejectionJames C Zimring; Fiscal Year: 2013..Thus, the proposed studies are relevant to the treatment/cure of a variety of diseases involving blood cell production. ..
- Cell Therapies for Cooley's AnemiaThomas M Ryan; Fiscal Year: 2013..creates novel preclinical animal models of CA that survive solely on human fetal hemoglobin at birth and are blood transfusion dependent for life upon completion of their hemoglobin switch after birth...
- Inhibition of platelet-leukocyte interactions to treat TRALIPaul S Frenette; Fiscal Year: 2010..mortality reported to the FDA, is a clinical syndrome in which acute lung injury occurs within 6 hours of a blood transfusion. Although its pathophysiology remains unclear, antibodies and/or bioactive lipids activating ..
- Optimizing Tissue Iron Quantification at 3 TeslaJohn C Wood; Fiscal Year: 2013..This work will broaden patient access to noninvasive iron estimation, improve detection of preclinical iron toxicity, and offer new insights in dynamic changes of iron storage pools. ..
- Protocolized Care for Early Septic Shock (ProCESS)Derek C Angus; Fiscal Year: 2012..whether all elements of the protocol are necessary, especially the use of central venous catheterization and blood transfusion. The apparent success of the Rivers protocol also prompts questions about the mechanisms by which ..
- Low-Cost, Noninvasive Liver Iron Measurements in African American Iron OverloadWilliam F Avrin; Fiscal Year: 2010..This new diagnostic tool, and the improved medical knowledge that it makes possible, will benefit millions of patients. ..
- Parathyroid Hormone in Prevention and Mitigation of ThrombocytopeniaAMELIA M BARTHOLOMEW; Fiscal Year: 2010....
- Babesiosis Emergence in the United StatesMARIA ANA DIUK-WASSER; Fiscal Year: 2013..Unlike Lyme disease, babesiosis is a potentially fatal disease and poses a threat to blood transfusion recipients...
- The SAIL trial [Sustained Aeration of Infant Lungs]Sarah J Ratcliffe; Fiscal Year: 2013..means of support in the delivery room as safe;tested a variety of lung interventions;and evaluated blood transfusion in the NICU...
- Global gene expression analysis of Trypanosoma cruzi under hyperosmotic stressRoberto Docampo; Fiscal Year: 2012..Chagas disease is a vector-borne disease that can also be transmitted by blood transfusion and is the leading cause of congestive heart failure in Latin America...
- Alternative Pathway Inhibitors for Orphan IndicationREKHA BANSAL; Fiscal Year: 2013..We will also conduct Rabbit PK-PD studies in phase II. These studies are essential for the development of a new therapeutic with potentially better benefits. ..
- Transfusion-Associated Brain Improvement (TABI) Trial: Data Coordinating CenterAbhik Das; Fiscal Year: 2013..Trial results could radically alter blood transfusion practices in the neonatal ICU...
- FOCUS Data Coordinating CenterMichael L Terrin; Fiscal Year: 2010..levels above 10 g/dl improves patient outcome as compared to a more conservative strategy that withholds blood transfusion until the patient develops symptoms of anemia...
- Myelodysplastic Syndromes: Patterns of Care and OutcomesXiaomei Ma; Fiscal Year: 2010..Findings from the study will be valuable to both clinicians caring for MDS patients and policy maker allocating health resources. ..
- Hepcidin Replacement Therapy for Iron Overload DisordersJames W Larrick; Fiscal Year: 2013..Hepcidin-Fc is expected to have activity equal to or better than hepcidin and have favorable pharmacokinetics with increased plasma half-life permitting once monthly administration. ..
- Platelet Transfusion Induced Transplant Rejection Across mHA barriers.James C Zimring; Fiscal Year: 2013..These studies have the potential to directly benefit patient populations who require platelet transfusions and subsequent BMT. ..
- Continuous monitoring of anti-fibrinolytic therapy in cardiovascular surgeryFrancis G Spinale; Fiscal Year: 2012..As a consequence, millions of patients that may be at risk for significant post-surgical bleeding will directly benefit from the development of this technology. ..
- Babesiosis: An Emerging Infectious Threat to Transfusion MedicineCheryl Ann Lobo; Fiscal Year: 2013..Human to human transmission of the parasite is well recognized to occur through blood transfusion. Despite being a significant threat to the safety of blood transfusions, its study has largely been ..
- Blood Transfusions: Gender Differences in Utilization, Predictors, and OutcomesMary A M Rogers; Fiscal Year: 2010DESCRIPTION (provided by applicant): Blood transfusion is the most common ICD-9-coded procedure performed in women during hospitalization in the United States...
- Therapeutic Monoclonal Antibodies for Human Prion DiseasesMARTIN JOSEPH SADOWSKI; Fiscal Year: 2010..Accidental prion infection in humans may occur as a result of blood transfusion or organ transplant, ingestion of prion contaminated food, or use of prion contaminated surgical instruments...
- Kidney Injury and Dysfunction Support (KIDS)Matthew Paden; Fiscal Year: 2010..inaccurate fluid balance leading to hypotension, excessive extracorporeal blood volumes leading to increased blood transfusion needs, and lack of compatibility with other extracorporeal devices such as extracorporeal membrane ..
- Reducing Mortality from Acute Hemorrhage in TraumaRHONDA K COOKE; Fiscal Year: 2012..Reducing death from acute hemorrhage in trauma care will be a major step forward in reducing overall trauma mortality. ..
- Sparing Conversion to Abnormal TCD ElevationRussell E Ware; Fiscal Year: 2012..of the conversion to abnormal TCD velocities would allow young patients to avoid exposure to prolonged blood transfusion and its associated toxicities (e.g., iron overload, alloimmunization, and infection)...
- Molecular Mechanisms of Blood Cell TransfusionLESLIE ERIC SILBERSTEIN; Fiscal Year: 2013..Our hypothesis is that the efficacy of blood transfusion can be improved via modulating these pathways...
- Massive Iron Deposit Assessment (MIDAS)Claudia M Hillenbrand; Fiscal Year: 2013..This will reduce treatment-related toxicity arising from unnecessary exposure to iron chelation and significantly improve patients'care and quality of life. ..
- Mechanically Stable Blood SubstitutesAndre Francis Palmer; Fiscal Year: 2010..The proposed work is both innovative and significant, because novel LEAcHb hybrid vesicles with engineered structural and mechanical characteristics will be created for use as an artificial blood substitute. ..
- Efficacy of Kunitz Domain 1 variants of TFPI-2 as novel antifibrinolytic agentsMADHU SATYA BAJAJ; Fiscal Year: 2010..In fact, aprotinin was the only FDA-approved drug to reduce blood transfusion in cardiac surgery with cardiopulmonary bypass...
- Rapid, noninvasive diagnosis and monitoring of shockDONALD SANDERSON PROUGH; Fiscal Year: 2010..delivery and anemia and to determine the need for therapy with fluids, inotropic or vasodilator drugs or blood transfusion. Current invasive techniques for measurement of venous SO2 and [Hgb] require central venous or pulmonary ..
- Transfusion Infection Pediatric Prospective Study (TRIPPS)NAOMI L LUBAN; Fiscal Year: 2011..specific aims of this continuation application are to prospectively study pediatric recipients of allogeneic blood transfusion to (1) determine the residual risk of transmitting known infections agents for which there are current donor ..
- Evaluation of Umbilical Cord Milking on Systemic Blood Flow in Premature InfantsAnup C Katheria; Fiscal Year: 2013..Increased blood flow may reduce the incidence of brain bleeding and subsequent developmental problems in very premature babies. ..
- Randomized trial of sertraline treatment of depression in Chronic Kidney DiseaseSUSAN HEDAYATI; Fiscal Year: 2013..will be assessed by a) proportion in each group with serious adverse events including bleeding requiring blood transfusion or hospitalization;b) type and severity of side effects reported on the Systemic Assessment for Treatment ..
- Randomized trial of sertraline treatment of depression in Chronic Kidney DiseaseSUSAN HEDAYATI; Fiscal Year: 2012..as compared with placebo, will result in more serious adverse events including bleeding requiring blood transfusion or hospitalization...
- Mechanisms of acute lung injury from blood transfusions.MARK ROBERTS LOONEY; Fiscal Year: 2013..In this proposal, we will determine how neutrophils and platelets interact with each other in the lung microcirculation to ultimately produce lung injury. ..
- Do Safety Warnings Change Prescribing among the US Dialysis Population?Mae Thamer; Fiscal Year: 2012..This study presents a unique opportunity to examine the dissemination of grave Black Box warnings and the willingness of physicians to modify prescribing habits in treating a vulnerable population of dialysis patients. ..
- STAT Palm-Sized Blood CounterEUGENE YAN HO CHAN; Fiscal Year: 2010..The palm-sized blood counter product is designed to provide much needed medical information during critical emergencies. ..
- Comparative Effectiveness: Erythropoietic Stimulating Agents in Treatment of MDSAmy J Davidoff; Fiscal Year: 2010..We will examine the characteristics of Medicare beneficiaries with MDS, patterns of treatment, safety and effectiveness of ESA use, and costs of care. ..
- Statistical Methodology Development in Blood Transfusion Protocol ResearchMohammad H Rahbar; Fiscal Year: 2013..Our new statistical methods are expected to have broad application across many different clinical contexts and dynamic data sets. ..
- Transfusion-associated immune hemolysisKarina Yazdanbakhsh; Fiscal Year: 2010..In our grant application, we will expand our animal studies to focus on the triggers that make immune cells accept or reject transfused blood. ..
- STAT Palm-Sized Blood CounterEUGENE YAN HO CHAN; Fiscal Year: 2013..The resulting product can be utilized in a wide- range of settings including ambulances, inpatient rooms, operating rooms, medical offices, and resource- starved settings. ..
- Restoration and Function of S-nitrosothiol in Stored BloodJonathan S Stamler; Fiscal Year: 2012..Restoration of NO bioactivity and oxygen delivery capabilities of stored RBCs will result in blood transfusion achieving its clinical purpose: vasodilation in the micro-circulation to maintain or enhance end- organ ..
- Primary Prevention of Strokes in Nigerian Children with Sickle Cell DiseaseLORI CHAFFIN JORDAN; Fiscal Year: 2013..The current primary prevention approach of regular monthly blood transfusion therapy of children at high risk of stroke (identified by elevated transcranial Doppler measurements) is not ..
- Investigating the Role of Malaria Rhoptry-Associated Protein 2 in Severe AnemiaNOE DAVID GOMEZ; Fiscal Year: 2010..The major way to manage malarial anemia is by blood transfusion, which is expensive...
- Twice-Weekly Subcutaneous Liposome Chelator to Treat Transfusional Iron OverloadMARK EAMON HAYES; Fiscal Year: 2013..The formulation will be easier and safer to administer than Desferal(R). If LDFO is validated, it would be a significant advance for the clinical treatment of transfusional iron overload in pediatric patients. ..
- Silent Cerebral Infarct Multi-Center Clinical Trial -SCCBruce Barton; Fiscal Year: 2009..The overall goal of this trial is to determine whether blood transfusion therapy will decrease further neurologic morbidity in children with Silent Cerebral Infarcts and, if so, the ..
- Bacterial heme transport and hemoglobin expressionDouglas Henderson; Fiscal Year: 2009..The goal of this research is to solve the production problems associated with making large amounts of hemoglobin in bacteria. ..
- NOVEL ANTIGENS FOR THE SERODIAGNOSIS OF HUMAN BABESIOSISRaymond Houghton; Fiscal Year: 2001..S. and worldwide. Current estimates for this market are 30-50 million dollars/year but could be greater if blood bank testing is mandated even on a regional basis. ..
- TRANSFUSION TRIGGER EXTENSION BY PLASMA EXPANDERSMarcos Intaglietta; Fiscal Year: 2009..Strategies for optimal follow up of plasma resuscitation and exchange with blood transfusion will be investigated.
- FOCUS Hip Fracture Transfusion Trial: Delirium and Other Cognitive OutcomesAnn L Gruber Baldini; Fiscal Year: 2010..trial of 2,000 hip fracture patients funded by the NHLBI designed to test the hypothesis that a higher blood transfusion threshold does not improve functional recovery or reduce morbidity and mortality...