artificial cardiac pacing

Summary

Summary: Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.

Top Publications

  1. ncbi Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Circulation 113:969-76. 2006
  2. ncbi Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay
    S Cazeau
    InParys, Saint-Cloud, France
    N Engl J Med 344:873-80. 2001
  3. ncbi Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony
    James A White
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Am Coll Cardiol 48:1953-60. 2006
  4. ncbi Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients
    C Butter
    , Campus Virchow Klinikum, Berlin, Germany
    Circulation 104:3026-9. 2001
  5. ncbi Cardiac resynchronization therapy cures dyssynchronopathy in canine left bundle-branch block hearts
    Kevin Vernooy
    Department of Physiology, Cardiovascular Research Institute Maastricht, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Eur Heart J 28:2148-55. 2007
  6. ncbi Doppler myocardial imaging to evaluate the effectiveness of pacing sites in patients receiving biventricular pacing
    Gerardo Ansalone
    Department of Heart Diseases, San Filippo Neri Hospital, Rome, Italy
    J Am Coll Cardiol 39:489-99. 2002
  7. ncbi Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms
    Cecilia Linde
    Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    J Am Coll Cardiol 52:1834-43. 2008
  8. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
  9. ncbi Different effects of cardiac resynchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: a two-dimensional speckle strain study
    Antonello D'Andrea
    Monaldi Hospital, Second University of Naples, Via G Martucci 35, 80121 Naples, Italy
    Eur Heart J 28:2738-48. 2007
  10. ncbi Cardiac resynchronization in chronic heart failure
    William T Abraham
    Division of Cardiovascular Medicine, University of Kentucky College of Medicine, Lexington 40536 0284, USA
    N Engl J Med 346:1845-53. 2002

Detail Information

Publications292 found, 100 shown here

  1. ncbi Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Circulation 113:969-76. 2006
    ..In the present study, the relationship between transmural posterolateral scar tissue and response to CRT was evaluated...
  2. ncbi Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay
    S Cazeau
    InParys, Saint-Cloud, France
    N Engl J Med 344:873-80. 2001
    ..001). CONCLUSIONS: Although it is technically complex, atriobiventricular pacing significantly improves exercise tolerance and quality of life in patients with chronic heart failure and intraventricular conduction delay...
  3. ncbi Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony
    James A White
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Am Coll Cardiol 48:1953-60. 2006
    ..We evaluated the ability of delayed enhancement magnetic resonance imaging (DE-MRI) to predict clinical response to cardiac resynchronization therapy (CRT)...
  4. ncbi Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients
    C Butter
    , Campus Virchow Klinikum, Berlin, Germany
    Circulation 104:3026-9. 2001
    ..Further studies are warranted to prove the clinical superiority of the LV free wall as a site for long-term CRT...
  5. ncbi Cardiac resynchronization therapy cures dyssynchronopathy in canine left bundle-branch block hearts
    Kevin Vernooy
    Department of Physiology, Cardiovascular Research Institute Maastricht, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Eur Heart J 28:2148-55. 2007
    ..We investigated to what extent biventricular pacing (BVP) can normalize LV function and remodeling, induced by isolated left bundle branch block (LBBB)...
  6. ncbi Doppler myocardial imaging to evaluate the effectiveness of pacing sites in patients receiving biventricular pacing
    Gerardo Ansalone
    Department of Heart Diseases, San Filippo Neri Hospital, Rome, Italy
    J Am Coll Cardiol 39:489-99. 2002
    ..The goal of this study was to compare the efficacy of biventricular pacing (BIV) at the most delayed wall of the left ventricle (LV) and at other LV walls...
  7. ncbi Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms
    Cecilia Linde
    Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    J Am Coll Cardiol 52:1834-43. 2008
    ....
  8. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
    ..We evaluated its effects on morbidity and mortality...
  9. ncbi Different effects of cardiac resynchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: a two-dimensional speckle strain study
    Antonello D'Andrea
    Monaldi Hospital, Second University of Naples, Via G Martucci 35, 80121 Naples, Italy
    Eur Heart J 28:2738-48. 2007
    ....
  10. ncbi Cardiac resynchronization in chronic heart failure
    William T Abraham
    Division of Cardiovascular Medicine, University of Kentucky College of Medicine, Lexington 40536 0284, USA
    N Engl J Med 346:1845-53. 2002
    ..We conducted a double-blind trial to evaluate this therapeutic approach...
  11. ncbi Optimal left ventricular lead position predicts reverse remodeling and survival after cardiac resynchronization therapy
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 52:1402-9. 2008
    ....
  12. ncbi Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice
    Nagesh Chopra
    Oates Institute for Experimental Therapeutics, and Division of Clinical Pharmacology, Vanderbilt University Medical Center, 1265 Medical Research Building IV, Nashville, TN 37232 0575, USA
    Circ Res 101:617-26. 2007
    ..The underlying mechanism is likely the direct regulation of SR Ca2+ release channels by Casq2 rather than altered luminal Ca2+...
  13. ncbi Left intraventricular myocardial deformation dyssynchrony identifies responders to cardiac resynchronization therapy in patients with heart failure
    Donato Mele
    Chair of Cardiology, Azienda Ospedaliera Universitaria, Ferrara, Italy
    Eur Heart J 27:1070-8. 2006
    ..We tested the hypothesis that dyssynchrony of left ventricular (LV) myocardial deformation evaluated by ultrasound can predict success of cardiac resynchronization therapy (CRT) in patients with heart failure (HF)...
  14. ncbi Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias
    Steven L Higgins
    Scripps Memorial Hospital, La Jolla, California 92038 0028, USA
    J Am Coll Cardiol 42:1454-9. 2003
    ..This study was conducted to assess the safety and effectiveness of cardiac resynchronization therapy (CRT) when combined with an implantable cardioverter defibrillator (ICD)...
  15. ncbi A new paradigm for physiologic ventricular pacing
    Michael O Sweeney
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 47:282-8. 2006
    ..Awareness of the problem of desynchronization should also lead to more regular monitoring of cardiac pump function and mechanical asynchrony in any patient with ventricular pacing...
  16. ncbi Simultaneous vs. sequential biventricular pacing in dilated cardiomyopathy: an acute hemodynamic study
    Giovanni B Perego
    Istituto Auxologico Italiano, Ospedale S Luca, Via Spagnoletto 3, 20149 Milan, Italy
    Eur J Heart Fail 5:305-13. 2003
    ..We tested the hypothesis that further improvements can be obtained using sequential biventricular pacing by optimizing both atrioventricular and interventricular delays...
  17. ncbi Novel speckle-tracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy
    Matthew S Suffoletto
    The Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Circulation 113:960-8. 2006
    ..Mechanical dyssynchrony is a potential means to predict response to cardiac resynchronization therapy (CRT). We hypothesized that novel echocardiographic image speckle tracking can quantify dyssynchrony and predict response to CRT...
  18. ncbi Benefits of cardiac resynchronization therapy for heart failure patients with narrow QRS complexes and coexisting systolic asynchrony by echocardiography
    Cheuk Man Yu
    Division of Cardiology, S H Ho Cardiovascular and Stroke Centre, Institute of Vascular Medicine, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Am Coll Cardiol 48:2251-7. 2006
    ..This study was designed to evaluate the role of cardiac resynchronization therapy (CRT) in heart failure (HF) patients with narrow QRS complexes (<120 ms) and echocardiographic evidence of mechanical asynchrony...
  19. ncbi Results of the Predictors of Response to CRT (PROSPECT) trial
    Eugene S Chung
    Lindner Clinical Trial Center, Cincinnati, OH 45219, USA
    Circulation 117:2608-16. 2008
    ..In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters to predict CRT response...
  20. pmc Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging
    F W Prinzen
    Department of Physiology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    J Am Coll Cardiol 33:1735-42. 1999
    ..The purpose of this study was to determine the spatial distribution of myocardial function (myofiber shortening and work) within the left ventricular (LV) wall during ventricular pacing...
  21. ncbi Role of L-type calcium channels in pacing-induced short-term and long-term cardiac memory in canine heart
    Alexei N Plotnikov
    Center for Molecular Therapeutics, Department of Pharmacology, College of Physicians and Surgeons of Columbia University, 630 W 168 St, PH7West 321, New York, NY 10032, USA
    Circulation 107:2844-9. 2003
    ..We tested the hypothesis that ICa,L is important to the development of cardiac memory...
  22. ncbi Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial
    Bruce L Wilkoff
    The Cleveland Clinic Foundation, 9500 Euclid Ave, Desk F 15, Cleveland, OH 44195, USA
    JAMA 288:3115-23. 2002
    ..Most currently implanted ICD devices provide dual-chamber pacing therapy. The most common comorbid cause for mortality in this population is congestive heart failure...
  23. ncbi Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation
    C A Carnes
    College of Pharmacy, Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio, USA
    Circ Res 89:E32-8. 2001
    ..The full text of this article is available at http://www.circresaha.org...
  24. ncbi Left ventricular-based cardiac stimulation post AV nodal ablation evaluation (the PAVE study)
    Rahul N Doshi
    Cardiovascular Consultants of Nevada, Las Vegas, Nevada 89074, USA
    J Cardiovasc Electrophysiol 16:1160-5. 2005
    ..The PAVE trial prospectively compared chronic biventricular pacing to right ventricular pacing in patients undergoing ablation of the AV node for management of atrial fibrillation with rapid ventricular rates...
  25. ncbi Functional abnormalities in patients with permanent right ventricular pacing: the effect of sites of electrical stimulation
    Hung Fat Tse
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong, China
    J Am Coll Cardiol 40:1451-8. 2002
    ..We sought to evaluate the long-term effects of alternative right ventricular pacing sites on myocardial function and perfusion...
  26. pmc Preventing ventricular fibrillation by flattening cardiac restitution
    A Garfinkel
    Department of Medicine Cardiology, Cardiovascular Research Laboratory, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 97:6061-6. 2000
    ..It even converts existing fibrillation, either to a periodic state (ventricular tachycardia, which is much more easily controlled) or to quiescent healthy tissue...
  27. ncbi Clinical and electrocardiographic predictors of a positive response to cardiac resynchronization therapy in advanced heart failure
    Guillaume Lecoq
    Department of Cardiology, Centre Hospitalier Universitaire, Rennes F 35000, France
    Eur Heart J 26:1094-100. 2005
    ..However, up to 30% of patients do not respond to CRT. The aim of this study was to identify clinical and electrocardiographic (ECG) predictors of a positive response to CRT...
  28. ncbi Predictors of lack of response to resynchronization therapy
    Ernesto Diaz-Infante
    Cardiovascular Institute, Hospital Clinic Universitari, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Am J Cardiol 95:1436-40. 2005
    ..023), severe mitral regurgitation (OR 3.5, 95% CI 1.3 to 9; p = 0.014), and left ventricular end-diastolic diameter > or =75 mm (OR 3.1, 95% CI 1.1 to 8; p = 0.026). Patients with these 3 predictors had a probability response of 27%...
  29. pmc Short-term pacing in the mouse alters cardiac expression of connexin43
    Andrianos Kontogeorgis
    Leon H, Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, USA
    BMC Physiol 8:8. 2008
    ..We hypothesized that alterations in connexin43 expression and localization in the mouse heart might be induced by ventricular pacing over a short period of time...
  30. ncbi Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay
    Angelo Auricchio
    Department of Cardiology, University Hospital, Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
    J Am Coll Cardiol 42:2109-16. 2003
    ..We assessed the clinical efficacy of single-site left ventricular (LV) pacing and determined the impact of baseline conduction delay severity on the magnitude of benefit...
  31. ncbi Pathobiology of left ventricular dyssynchrony and resynchronization
    David D Spragg
    Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Prog Cardiovasc Dis 49:26-41. 2006
    ..The effects of resynchronization on the tissue-level and molecular consequences of dyssynchrony remain unknown...
  32. ncbi Characterization of left ventricular activation in patients with heart failure and left bundle-branch block
    Angelo Auricchio
    Division of Cardiology, University Hospital, Leipzigerstrasse 44, D 39120 Magdeburg, Germany
    Circulation 109:1133-9. 2004
    ....
  33. ncbi Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial
    James B Young
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 289:2685-94. 2003
    ....
  34. ncbi The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
    ....
  35. ncbi Left ventricular strain patterns in dilated cardiomyopathy predict response to cardiac resynchronization therapy: timing is not everything
    Shemy Carasso
    University Health Network, University of Toronto, Toronto, Canada
    J Am Soc Echocardiogr 22:242-50. 2009
    ..The aim of this study was to develop prediction rules for successful CRT on the basis of mechanical strain patterns of left ventricular function rather than just the timing of activation...
  36. ncbi Minimizing ventricular pacing to reduce atrial fibrillation in sinus-node disease
    Michael O Sweeney
    Cardiac Arrhythmia Service, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 357:1000-8. 2007
    ....
  37. ncbi Optimizing the programation of cardiac resynchronization therapy devices in patients with heart failure and left bundle branch block
    Barbara Vidal
    Thorax Clinic Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Cardiol 100:1002-6. 2007
    ..In conclusion, the echocardiographic optimization of cardiac resynchronization devices provided a slight incremental clinical benefit at midterm follow-up. Simple and rapid methods to routinely optimize the devices are warranted...
  38. ncbi Biventricular pacing and left ventricular pacing in heart failure: similar hemodynamic improvement despite marked electromechanical differences
    Pierre Bordachar
    Hopital Cardiologique du Haut Leveque, Pessac, France
    J Cardiovasc Electrophysiol 15:1342-7. 2004
    ..We sought to clarify the mechanisms responsible for similar hemodynamic improvement despite differences in electrical activation...
  39. ncbi Magnetic resonance imaging assessment of ventricular dyssynchrony: current and emerging concepts
    Albert C Lardo
    Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Coll Cardiol 46:2223-8. 2005
    ....
  40. ncbi Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Pacing Therapies for Congestive Heart Failure Study Group. The Guidant Congestive Heart Failure Research Group
    A Auricchio
    Department of Cardiology, University Hospital, Otto von Guericke Universitat, Magdeburg, Germany
    Circulation 99:2993-3001. 1999
    ..These variables were compared by a novel technique that evaluated immediate changes in hemodynamic function during brief periods of atrial-synchronous ventricular pacing...
  41. ncbi Role of calcium cycling versus restitution in the mechanism of repolarization alternans
    Etienne J Pruvot
    Heart and Vascular Research Center and the Department of Biomedical Engineering, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109 1998, USA
    Circ Res 94:1083-90. 2004
    ..In conclusion, the mechanism underlying T-wave alternans in the intact heart is more closely associated with intracellular Ca2+ cycling rather than APD restitution...
  42. ncbi Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay
    D A Kass
    Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 99:1567-73. 1999
    ....
  43. ncbi American Society of Echocardiography recommendations for performance, interpretation, and application of stress echocardiography
    Patricia A Pellikka
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Soc Echocardiogr 20:1021-41. 2007
  44. ncbi Peak endocardial acceleration reflects heart contractility also in atrial fibrillation
    T Bombardini
    Servizio di Tecnologie Biomediche Policlinico S Orsola, Bologna, Italy
    Pacing Clin Electrophysiol 23:1381-5. 2000
    ..These data confirm that PEA reflects heart contractility also during AF and hold promise for the use of this sensor in therapeutic implantable devices...
  45. pmc Cardiac dyssynchrony analysis using circumferential versus longitudinal strain: implications for assessing cardiac resynchronization
    Robert H Helm
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, 720 Rutland Ave, Baltimore, MD 21205, USA
    Circulation 111:2760-7. 2005
    ..It is unknown whether this analysis yields qualitative and/or quantitative results similar to those based on motion in the predominant muscle-fiber orientation (circumferential; epsiloncc)...
  46. pmc Comparison of permanent left ventricular and biventricular pacing in patients with heart failure and chronic atrial fibrillation: prospective haemodynamic study
    S Garrigue
    Hopital Cardiologique du Haut Leveque, University of Bordeaux, Bordeaux Pessac, France Sorin Biomedica, 9, rue Georges Besse, Bat 4, 92160 Antony, France
    Heart 87:529-34. 2002
    ....
  47. ncbi Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase]
    John G F Cleland
    Academic Unit of Cardiology, Department of Cardiology, Castle Hill Hospital, University of Hull, Castle Road, Cottingham, Kingston upon Hull, East Yorkshire, UK
    Eur Heart J 27:1928-32. 2006
    ..4 months [median 29.6, interquartile range (IQR) 23.6-34.6]. Prior to study closure, an extension phase lasting a further 8 months (allowing time for data analysis and presentation) was declared during which cross-over was discouraged...
  48. ncbi Short- and long-term outcome of children with congenital complete heart block diagnosed in utero or as a newborn
    M Eronen
    Hospital for Children and Adolescents, Helsinki University Hospital, Helsinki, Finland
    Pediatrics 106:86-91. 2000
    ....
  49. ncbi Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in collaboration with the European Heart Rhythm Association
    Panos E Vardas
    Department of Cardiology, Heraklion University Hospital, PO Box 1352 Stavrakia, GR 711 10 Heraklion Crete, Greece
    Eur Heart J 28:2256-95. 2007
  50. ncbi Randomized comparison of simultaneous biventricular stimulation versus optimized interventricular delay in cardiac resynchronization therapy. The Resynchronization for the HemodYnamic Treatment for Heart Failure Management II implantable cardioverter defi
    Giuseppe Boriani
    Institute of Cardiology, University of Bologna, Azienda Ospedaliera S Orsola Malpighi, Bologna, Italy
    Am Heart J 151:1050-8. 2006
    ..The clinical value of interventricular (V-V) delay optimization in patients with chronic congestive heart failure (CHF) undergoing implantation of a device for cardiac resynchronization therapy (CRT) has not been clearly demonstrated...
  51. ncbi Three-dimensional mapping of optimal left ventricular pacing site for cardiac resynchronization
    Robert H Helm
    Division of Cardiology, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA
    Circulation 115:953-61. 2007
    ..The geographic extent and 3-dimensional distribution of left ventricular (LV) locations yielding optimal CRT remain unknown...
  52. ncbi Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial-tachycardia remodeling in dogs
    Akiko Shiroshita-Takeshita
    Department of Medicine, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada
    Circulation 110:2313-9. 2004
    ..Statins have both antioxidant and antiinflammatory properties. We compared the effects of simvastatin with those of antioxidant vitamins on AF promotion by atrial tachycardia in dogs...
  53. ncbi Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure
    Martin G St John Sutton
    Division of Cardiology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Circulation 107:1985-90. 2003
    ..The purpose of the present study was to determine whether improvements in left ventricular (LV) size and function were associated with CRT...
  54. pmc The effects of aetiology on outcome in patients treated with cardiac resynchronization therapy in the CARE-HF trial
    Gerhard Wikstrom
    Department of Cardiology, Institute of Medical Sciences, Akademiska Hospital, University of Uppsala, Uppsala, Sweden
    Eur Heart J 30:782-8. 2009
    ..The effect of the underlying cause of cardiac dysfunction on the response to cardiac resynchronization therapy (CRT) is unknown. This issue was addressed using data from the CARE-HF trial...
  55. ncbi Impact of left ventricular lead position in cardiac resynchronization therapy on left ventricular remodelling. A circumferential strain analysis based on 2D echocardiography
    Michael Becker
    Medical Clinic I, Department of Cardiology, University RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur Heart J 28:1211-20. 2007
    ..Aims: To assess if myocardial deformation imaging allows definition of an optimal left ventricular (LV) lead position with improved effectiveness of cardiac resynchronization therapy (CRT) on LV reverse remodelling...
  56. ncbi Reduced ventricular volumes and improved systolic function with cardiac resynchronization therapy: a randomized trial comparing simultaneous biventricular pacing, sequential biventricular pacing, and left ventricular pacing
    Rajni K Rao
    University of California, San Francisco, Department of Medicine, Division of Cardiology, 505 Parnassus Ave, San Francisco, CA 94143 0214, USA
    Circulation 115:2136-44. 2007
    ..The Device Evaluation of CONTAK RENEWAL 2 and EASYTRAK 2: Assessment of Safety and Effectiveness in Heart Failure (DECREASE-HF) trial is the first randomized trial comparing these 3 cardiac resynchronization therapy modalities...
  57. ncbi Left ventricular dyssynchrony predicts right ventricular remodeling after cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 46:2264-9. 2005
    ..The purpose of this research was to evaluate right ventricular (RV) remodeling after six months of cardiac resynchronization therapy (CRT)...
  58. ncbi Programmable multiple pacing configurations help to overcome high left ventricular pacing thresholds and avoid phrenic nerve stimulation
    Osnat Gurevitz
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pacing Clin Electrophysiol 28:1255-9. 2005
    ..Newer systems capable of multiple LVP configurations may help overcome these problems without the need for reoperation...
  59. ncbi Cardiac resynchronization therapy for chronic heart failure: why does it not always work?
    C Richard Conti
    Clin Cardiol 29:335-6. 2006
    ..2) Viable myocardium in the septum and the LV free wall. (3) Adequate perfusion of the microcirculation in the distribution where the leads are being placed...
  60. ncbi Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure
    C Leclercq
    Departement de Cardiologie, Hopital Pontchaillou, Rennes, France
    J Am Coll Cardiol 32:1825-31. 1998
    ..The aim of this study was to assess the potential acute benefit of multisite cardiac pacing with optimized atrioventricular synchrony and simultaneous biventricular pacing in patients with drug-refractory congestive heart failure (CHF)...
  61. ncbi Effects of biventricular pacing on myocardial blood flow and oxygen consumption using carbon-11 acetate positron emission tomography in patients with heart failure
    Frieder Braunschweig
    Department of Cardiology, Karolinska Hospital, Stockholm, Sweden
    Am J Cardiol 92:95-9. 2003
  62. ncbi Time course of effects of cardiac resynchronization therapy in chronic heart failure: benefits in patients with preserved exercise capacity
    Massimo F Piepoli
    Heart Failure Unit, Cardiac Department, G da Saliceto Polichirurgico Hospital, Piacenza, Italy
    Pacing Clin Electrophysiol 31:701-8. 2008
    ..To assess in patients with chronic heart failure the effect of cardiac resynchronization therapy (CRT) over 12 months' follow-up the time course of the changes in functional and neurohormonal indices and to identify responders to CRT...
  63. doi Patient selection and echocardiographic assessment of dyssynchrony in cardiac resynchronization therapy
    Lisa J Anderson
    Department of Cardiology, St George s Hospital, London, United Kingdom
    Circulation 117:2009-23. 2008
  64. ncbi Acute effects of initiation and withdrawal of cardiac resynchronization therapy on papillary muscle dyssynchrony and mitral regurgitation
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 50:2071-7. 2007
    ..The effect of interruption of CRT at 6 months' follow-up on dyssynchrony and MR was also evaluated...
  65. ncbi Beneficial effects of statin therapy for prevention of atrial fibrillation following DDDR pacemaker implantation
    Anne M Gillis
    Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary and Calgary Health Region, Calgary, AB, Canada
    Eur Heart J 29:1873-80. 2008
    ..The clinical predictors of at/af recurrence following dual-chamber pacemaker insertion were examined in 185 consecutive patients with paroxysmal AF...
  66. ncbi Late gadolinium enhancement-cardiovascular magnetic resonance as a predictor of response to cardiac resynchronization therapy in patients with ischaemic cardiomyopathy
    Shajil Chalil
    Department of Cardiology, University of Birmingham, Good Hope Hospital, Rectory Road, Sutton Coldfield, West Midlands B75 7RR, UK
    Europace 9:1031-7. 2007
    ..To determine whether myocardial scarring, quantified using late gadolinium enhancement-cardiovascular magnetic resonance (LGE-CMR), predicts response to cardiac resynchronization therapy (CRT)...
  67. ncbi Ventricular function and long-term pacing in children with congenital complete atrioventricular block
    Jeffrey J Kim
    Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    J Cardiovasc Electrophysiol 18:373-7. 2007
    ..To determine the sequela of right ventricular pacing in children with congenital complete atrioventricular block...
  68. ncbi Cardiac resynchronization therapy or atrio-biventricular pacing-what should it be called?
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull HU16 5TX, UK
    Nat Clin Pract Cardiovasc Med 4:90-101. 2007
    ..Here, we examine the evidence that cardiac resynchronization is indeed the mechanism by which atrio-biventricular pacing exerts its effects...
  69. ncbi Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction
    Michael O Sweeney
    Cardiac Arrhythmia Service, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 107:2932-7. 2003
    ..The effect of pacing-induced ventricular desynchronization in patients with normal baseline QRSd is unknown...
  70. ncbi Ventricular asynchrony predicts a better outcome in patients with chronic heart failure receiving cardiac resynchronization therapy
    Maria Vittoria Pitzalis
    Institute of Cardiology, University of Bari, Bari, Italy
    J Am Coll Cardiol 45:65-9. 2005
    ..The aim of this study was to evaluate whether the clinical benefit of cardiac resynchronization therapy (CRT) can be prospectively predicted by means of the baseline evaluation of left ventricular asynchrony...
  71. ncbi Usefulness of tissue Doppler velocity and strain dyssynchrony for predicting left ventricular reverse remodeling response after cardiac resynchronization therapy
    Cheuk Man Yu
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Am J Cardiol 100:1263-70. 2007
    ..In conclusion, parameters of tissue Doppler longitudinal velocity, but not longitudinal strain, predicted LV reverse remodeling after CRT...
  72. ncbi Resynchronization therapy in pediatric and congenital heart disease patients: an international multicenter study
    Anne M Dubin
    Lucile Packard Children s Hospital, Palo Alto, California, USA
    J Am Coll Cardiol 46:2277-83. 2005
    ..Our objective was to evaluate the short-term safety and efficacy of cardiac resynchronization therapy (CRT) in children...
  73. ncbi Programming optimal atrioventricular delay in dual chamber pacing using peak endocardial acceleration: comparison with a standard echocardiographic procedure
    Jean Marc Dupuis
    Department of Cardiology, University Hospital of Angers, 4 rue Larrey, 49033 Angers, France
    Pacing Clin Electrophysiol 26:210-3. 2003
    ..The proposed algorithm can be used for automatic OAVD determination in an implanted pacemaker pulse generator...
  74. ncbi Decrease in plasma B-type natriuretic peptide early after initiation of cardiac resynchronization therapy predicts clinical improvement at 12 months
    Milos Kubanek
    Department of Cardiology, Institute for Clinical and Experimental Medicine, Vídesnská 1958 9, Prague 140 21, Czech Republic
    Eur J Heart Fail 8:832-40. 2006
    ..We tested the hypothesis that changes in neurohormonal activation after initiation of cardiac resynchronization therapy (CRT) predict its long-term clinical effect...
  75. ncbi Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials
    David J Bradley
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    JAMA 289:730-40. 2003
    ..Cardiac resynchronization, a pacemaker-based therapy for heart failure, enhances cardiac performance and quality of life, but its effect on mortality is uncertain...
  76. ncbi Atrioventricular junction ablation followed by resynchronization therapy in patients with congestive heart failure and atrial fibrillation (AVERT-AF) study design
    Mohamed H Hamdan
    Department of Internal Medicine, Division of Cardiology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132 2401, USA
    Pacing Clin Electrophysiol 29:1081-8. 2006
    ..Patients_enrollment will begin in summer 2006 and is expected to be completed in 2008. The results of this trial should help define the best treatment option for this common arrhythmia in patients with left ventricular dysfunction...
  77. ncbi Clinical predictors of marked improvement in left ventricular performance after cardiac resynchronization therapy in patients with chronic heart failure
    Maurizio Mangiavacchi
    Department of Cardiology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Am Heart J 151:477.e1-477.e6. 2006
    ..However, it is not yet clear which patients will benefit from the procedure the most. The purpose of the study was to identify the pre-implant characteristics that better predict which patients will have the best outcome after CRT...
  78. ncbi Cardiac resynchronization therapy in patients with end-stage inotrope-dependent class IV heart failure
    Bengt Herweg
    Division of Cardiology, Tampa General Hospital, University of South Florida College of Medicine, Tampa, Florida, USA
    Am J Cardiol 100:90-3. 2007
    ..In conclusion, patients with end-stage inotrope-dependent NYHA class IV HF and LV dyssynchrony may respond favorably to CRT with long-term clinical benefit and improved LV function...
  79. ncbi Severe atrioventricular decoupling, uncoupling, and ventriculoatrial coupling during enhanced atrial pacing: incidence, mechanisms, and implications for minimizing right ventricular pacing in ICD patients
    Michael O Sweeney
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Cardiovasc Electrophysiol 19:1175-80. 2008
    ..AV Decoupling During Enhanced AAIR Pacing...
  80. ncbi Reducing unnecessary right ventricular pacing with the managed ventricular pacing mode in patients with sinus node disease and AV block
    Anne M Gillis
    Libin Cardiovascular Institute of Alberta and Department of Cardiovascular Sciences, University of Calgary and Calgary Health Region, Calgary, Alberta, Canada
    Pacing Clin Electrophysiol 29:697-705. 2006
    ..We evaluated a new pacing algorithm, managed ventricular pacing (MVP) which automatically changes modes between AAI/R and DDD/R in patients receiving pacemakers for symptomatic bradycardia...
  81. ncbi Ventricular resynchronization: current state of the art
    Christophe Leclercq
    The Johns Hopkins Hospital, Cardiology Division, 600 N Wolfe St, Carnegie 568, Baltimore, MD 21287 6568, USA
    Circulation 109:296-9. 2004
  82. ncbi FDG PET as a predictor of response to resynchronisation therapy in patients with ischaemic cardiomyopathy
    C M C van Campen
    Department of Cardiology, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 34:309-15. 2007
    ....
  83. ncbi Long-term prognosis after cardiac resynchronization therapy is related to the extent of left ventricular reverse remodeling at midterm follow-up
    Claudia Ypenburg
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 53:483-90. 2009
    ....
  84. ncbi Comparison of acute changes in left ventricular volume, systolic and diastolic functions, and intraventricular synchronicity after biventricular and right ventricular pacing for heart failure
    Cheuk Man Yu
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Am Heart J 145:E18. 2003
    ....
  85. ncbi Cardiac resynchronization therapy: Part 2--issues during and after device implantation and unresolved questions
    Jeroen J Bax
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 46:2168-82. 2005
    ..Finally, open questions concerning when to combine CRT with implantable cardioverter-defibrillator therapy and the cost-effectiveness of CRT are discussed...
  86. ncbi Epicardial left ventricular lead placement for cardiac resynchronization therapy: optimal pace site selection with pressure-volume loops
    A L A J Dekker
    Department of Cardio Thoracic Surgery, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, Maastricht, The Netherlands
    J Thorac Cardiovasc Surg 127:1641-7. 2004
    ..The objective of this study was to develop a method to guide epicardial lead placement in cardiac resynchronization therapy...
  87. ncbi Tissue synchronization imaging and optimal left ventricular pacing site in cardiac resynchronization therapy
    Ross T Murphy
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 97:1615-21. 2006
    ..In conclusion, pacing at the site of maximal mechanical delay was associated with reverse remodeling. Individually tailored LV lead positioning should be considered before CRT...
  88. ncbi Predicting the long-term effects of cardiac resynchronization therapy on mortality from baseline variables and the early response a report from the CARE-HF (Cardiac Resynchronization in Heart Failure) Trial
    John Cleland
    Department of Cardiology, University of Hull, Hull, United Kingdom
    J Am Coll Cardiol 52:438-45. 2008
    ..This study was designed to investigate whether selected baseline variables and early response markers predict the effects of cardiac resynchronization therapy (CRT) on long-term mortality...
  89. ncbi Comparison of effectiveness of cardiac resynchronization therapy in patients <70 versus > or =70 years of age
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 96:420-2. 2005
    ..Survival was evaluated up to 2 years. The effects of CRT in elderly patients (age > or =70 years) were compared with those in younger patients (age <70 years)...
  90. ncbi Impact of automatic adjustment of stimulation outputs on pacemaker longevity in a new dual-chamber pacing system
    Christiane Brockes
    Cardiovascular Surgery, Cardiovascular Center, University Hospital, Zurich, Switzerland
    J Interv Card Electrophysiol 8:45-8. 2003
    ..Jude Medical) in comparison to the longevity of a previous model from the same manufacturer without AC (Trilogy DR)...
  91. ncbi Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy: analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Circulation 116:1440-8. 2007
    ..The time course and the extent of LV resynchronization after CRT implantation and their relationship to response are currently unknown...
  92. ncbi Feasibility of adjusting paced left ventricular activation by manipulating stimulus strength
    Usha Tedrow
    J Am Coll Cardiol 44:2249-52. 2004
  93. pmc Optimal use of echocardiography in cardiac resynchronisation therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Heart 93:1339-50. 2007
    ..Echocardiography is also useful to evaluate long-term benefit from CRT. Finally, echocardiography is important in optimisation of pacemaker settings, including AV and VV optimisation...
  94. ncbi A fast and simple echocardiographic method of determination of the optimal atrioventricular delay in patients after biventricular stimulation
    Jaroslav Meluzin
    First Department of Internal Medicine, St Anna Hospital, Masaryk University, Brno, Czech Republic
    Pacing Clin Electrophysiol 27:58-64. 2004
    ..The method correctly determined the maximum CO in 78% of the patients. In conclusion, Doppler echocardiography enables very rapid and accurate optimization of AV synchrony in patients after the implantation of a biventricular pacemaker...
  95. ncbi Prospective randomized multicenter trial of empirical antitachycardia pacing versus shocks for spontaneous rapid ventricular tachycardia in patients with implantable cardioverter-defibrillators: Pacing Fast Ventricular Tachycardia Reduces Shock Therapies
    Mark S Wathen
    Vanderbilt Page Campbell Heart Institute, Vanderbilt University Medical Center, 2220 Pierce, Nashville, TN 37232, USA
    Circulation 110:2591-6. 2004
    ..Fast VT (FVT) >200 bpm is often treated by shock because of safety concerns, however. This prospective, randomized, multicenter trial compares the safety and utility of empirical ATP with shocks for FVT in a broad ICD population...
  96. ncbi Left ventricular pacing minimizes diastolic ventricular interaction, allowing improved preload-dependent systolic performance
    R A Bleasdale
    Department of Cardiology, Wales Heart Research Institute, Heath Park, Cardiff CF14 4XN, United Kingdom
    Circulation 110:2395-400. 2004
    ..Left ventricular (LV) pacing improves hemodynamics in patients with heart failure. We hypothesized that at least part of this benefit occurs by minimization of external constraint to LV filling from ventricular interaction...
  97. ncbi Importance of contractile reserve for CRT
    Pascal Lim
    Department of Cardiology, APHP, Henri Mondor Hospital, 51 Av du Marechal de Lattre de Tassigny, 94000, Creteil, France
    Europace 9:739-43. 2007
    ..Non-response to CRT may partly be due to inefficient pacing by the LV lead located in a fibrotic area...
  98. ncbi Limited thoracotomy as a second choice alternative to transvenous implant for cardiac resynchronisation therapy delivery
    Andrea Puglisi
    Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy
    Eur Heart J 25:1063-9. 2004
    ..The aim of this study was to assess whether LV pacing via limited thoracotomy would be feasible and safe when used on a routine basis for those cases in which standard transvenous procedures proved to be ineffective or unsatisfactory...
  99. ncbi Midterm benefits of left univentricular pacing in patients with congestive heart failure
    Jean Jacques Blanc
    Brest University Hospital, Brest, France
    Circulation 109:1741-4. 2004
    ..The objective of this study was to assess the outcome over a 1-year period of patients paced exclusively in the left ventricle...
  100. ncbi Spatial dispersion of action potential duration restitution kinetics is associated with induction of ventricular tachycardia/fibrillation in humans
    Hui Nam Pak
    Division of Cardiology, Korea University Cardiovascular Center, Seoul, Korea
    J Cardiovasc Electrophysiol 15:1357-63. 2004
    ..We hypothesized that the steeply sloped APDR and its spatial heterogeneity contribute to VT/VF inducibility in patients with ventricular arrhythmia...
  101. ncbi Functional impact of rate irregularity in patients with heart failure and atrial fibrillation receiving cardiac resynchronization therapy
    Vojtech Melenovsky
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Eur Heart J 26:705-11. 2005
    ..However, it remains uncertain whether rhythm irregularity per se has unfavourable effects apart from tachycardia, and whether rate regularization alone can improve heart function...

Research Grants62

  1. ATRIAL FIBRILLATION: MECHANISMS AND PREVENTION
    Michael Rosen; Fiscal Year: 2003
    ....
  2. Mechanistic Determinants of Pacing-induced Cardiac Memory
    Michael R Rosen; Fiscal Year: 2010
    ..Rather than being reductionist, the approach attempts to synthesize information so that we can better comprehend and impact on a clinically important problem. ..
  3. Cardiovascular Development and Disease in the Young
    Michael Rosen; Fiscal Year: 2008
    ..abstract_text> ..
  4. ACTION-A CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISE
    William Abraham; Fiscal Year: 2005
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  5. THERAPUTIC TRIAL IN PATIENTS WITH LQTS 3 GENE MUTATION
    Arthur Moss; Fiscal Year: 2002
    ..The significance of this work relates to the future use of molecular therapeutics to treat ion-channel disorders associated with congenital and acquired cardiac repolarization disorders. ..
  6. LONG QT SYNDROME--GENETIC STUDIES
    Arthur Moss; Fiscal Year: 2002
    ....
  7. THROMBOGENIC FACTORS AND RECURRENT CORONARY EVENTS
    Arthur Moss; Fiscal Year: 2003
    ..abstract_text> ..
  8. Ethanol Effects of SR Ca2+ Release in Cardiac Myocytes
    J Wasserstrom; Fiscal Year: 2005
    ....
  9. Cardiovascular Stiffening in Aged Patients with CHF
    David Kass; Fiscal Year: 2005
    ..This could lead to new therapeutic approaches to this difficult clinical problem that affects a growing aged patient population. ..
  10. Role of Stretch to Endothelial Pulse-Perfusion Response
    David Kass; Fiscal Year: 2005
    ..abstract_text> ..
  11. Visualizing the Substrate for Sudden Cardiac Death
    Vivek Reddy; Fiscal Year: 2006
    ..abstract_text> ..
  12. NUMERICAL SIMULATION OF CARDIAC ELECTROPHYSIOLOGY
    Bradley Roth; Fiscal Year: 2005
    ..Each hypothesis is motivated by experimental data, and the goal of the theoretical simulations is to interpret these data. ..
  13. The Pathophysiology of T-wave Alternans
    Sanjiv Narayan; Fiscal Year: 2005
    ..This structured approach will ensure the successful completion of this project and, in this way, the development of the applicant into an independent clinician-investigator. ..
  14. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2007
    ..abstract_text> ..
  15. Sex Differences in Early Myocardial Repolarization
    Alan Kadish; Fiscal Year: 2008
    ..It is hoped that the results of this study will improve the understanding of myocardial physiology and improve risk stratification and therapy for arrhythmias by uncovering important sex related differences. ..
  16. Substrate Mapping & Ablation of Ventricular Tachycardia
    Vivek Reddy; Fiscal Year: 2006
    ..abstract_text> ..
  17. NEURAL MECHANISMS OF VENTRICULAR ELECTRICAL REMODELING
    Philip Adamson; Fiscal Year: 2003
    ..These clinically applicable interventions may modify the natural history of diseases, such as heart failure, characterized by ventricular electrical remodeling leading to a high risk for lethal arrhythmias. ..
  18. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2008
    ..4) To study the properties and repolarization-dependent mechanisms of arrhythmias in the remodeled myocardium post myocardial infarction. ..
  19. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
    ..We will determine if a class of drugs called statins has the potential for reducing some of the deleterious consequences of compensatory mechanisms in the heart failure state. ..
  20. Cost Effectiveness of Catheter Ablation for Atrial Fibrillation (AF)
    Matthew Reynolds; Fiscal Year: 2008
    ..Once all of this data is collected, the necessary inputs will combined in a Markov model comparing AF ablation with antiarrhythmic drug therapy, and atrio-ventricular junctional ablation with pacemaker implantation. ..
  21. Androgens and Myocardial Relaxation in the Aging Heart
    Theodore Abraham; Fiscal Year: 2008
    ..Most importantly, potential direct clinical benefits of this research include early detection, improved and novel therapy, and better clinical outcomes for age-related diastolic dysfunction. ..
  22. ALCOHOL MODULATION OF CARDIAC CALCIUM CHANNELS
    Gary Aistrup; Fiscal Year: 2003
    ..This novel action may have major implications, given the widespread clinical use of dihydropyridines and other calcium channel antagonists. Drug interactions of this type will be an important focus of the project. ..
  23. Particulate Matter Exposure: Cardiovascular Mechanisms
    Chao Yin Chen; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  24. Nanosecond megavolt pulse technology for cardiac stimulation and defibrillation
    Miguel Valderrabano; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. Cellular Cardiomyoplasty in Vitro: Host-Donor Cell Interactions
    Nenad Bursac; Fiscal Year: 2007
    ..The final aim is to aid in the development of efficient and safe cell-based approaches for the treatment of regional heart injury due to ischemia, infarction, or congenital defects. [unreadable] [unreadable] [unreadable]..
  26. Tau Nitration in Alzheimer's Pathogenesis
    Matthew Reynolds; Fiscal Year: 2007
    ..In this proposal, we will characterize the specific sites of T nitration in vitro and in situ, and determine the effects of nitration on T folding and function. ..
  27. Molecular Pathology of Cardic Arrhythmias
    Dan Roden; Fiscal Year: 2003
    ..abstract_text> ..
  28. Inhomogeneous Sympathetic Innervation in IHD
    JAMES FALLAVOLLITA; Fiscal Year: 2008
    ..Therefore, these studies will translate basic observations in animals to clinical pathophysiology in humans and identify novel substrate factors that contribute to the risk of SD in chronic ischemic heart disease. ..
  29. Functional Coupling between Ito and ICa in Cardiomyocytes
    Yanggan Wang; Fiscal Year: 2010
    ..The proposed study implicates a cell membrane potassium channel (Ito) in regulating the cellular calcium influx channel (ICa) function, which may decipher a new mechanism for this morbid disease. ..
  30. An Ultrasonic Neural Stimulator
    BRUCE TOWE; Fiscal Year: 2002
    ..This market is currently served with conventional electrostimulators by large medical device companies like Medtronic, Guidant, and others. ..
  31. Electrophysiological and antiarrhythmic benefit of cell therapy for heart disease
    KENNETH LAURITA; Fiscal Year: 2010
    ..The long-term goal of this study is to develop a cure for SCD associated with IHD. ..
  32. VENTRICULAR FIBRILLATION AND ITS ALTERATION BY PACING
    Raymond E Ideker; Fiscal Year: 2010
    ..We will test the hypotheses that pacing from the dominant domain (1) captures the maximum amount of tissue during VF and (2) halts the most organized types of VF. ..
  33. INTRINSIC CARDIAC NEURONS AND CARDIAC CONTROL
    JEFFREY ARDELL; Fiscal Year: 2001
    ..Specific Aim 5. To determine if restoration of circulating catecholamines alleviates the cardiodepression associated with chronic adrenalectomy with and without concurrent prolonged loss of extrinsic nerve inputs to the heart. ..
  34. Calcium Signaling, Metabolism, and EC Coupling in Heart
    JOSHUA GOLDHABER; Fiscal Year: 2008
    ..abstract_text> ..
  35. COMPUTER ASSISTED MAPPING OF VENTRICULAR FIBRILLATION
    Raymond Ideker; Fiscal Year: 2009
    ..This understanding will give us new information needed to develop therapies to counteract these mechanisms of VF maintenance to prevent sudden cardiac arrest, one of the leading health problems in the world today. ..
  36. Automated Storage and Retrieval of Biological Systems
    Dan Roden; Fiscal Year: 2008
    ..Accordingly, this proposal requests a high end instrument to accomplish these goals, and to thereby enable a new era of Personalized Medicine. [unreadable] [unreadable] [unreadable] [unreadable]..
  37. STICH TRIAL - NEUROHORMONAL/ CYTOKINE/ GENETIC CORE LAB
    Arthur Feldman; Fiscal Year: 2007
    ..Low expression of ACE gene or high levels of adenosine) will be most likely to achieve long-term benefit from either CABG or CABG with SVR. ..
  38. Prognostic significance of T wave variability
    Eric Rashba; Fiscal Year: 2006
    ..2) Patients with increased T wave variability derive a greater mortality benefit from prophylactic ICD implantation. ..
  39. Arrhythmia Assessment Core Lab for IMMEDIATE Trial
    Eric Rashba; Fiscal Year: 2006
    ..End of abstract.) [unreadable] [unreadable]..
  40. New ECG Criteria for Posterior Myocardial Infarction
    Shu Fen Wung; Fiscal Year: 2004
    ..This study will aid in the detection and follow-up of patients with posterior myocardial infarction. ..
  41. Novel Methods for Cardiac Micro-Impedance Measurement
    Andrew Pollard; Fiscal Year: 2005
    ..abstract_text> ..
  42. Renin Angiotensin for Coronary Microvascular Dysfunction
    Carl Pepine; Fiscal Year: 2005
    ....
  43. FETAL AND NEONATAL MEG
    Ronald Wakai; Fiscal Year: 2005
    ..Such a technology would be extremely valuable in the identification of fetuses with brain dysfunction due to chronic intrauterine central nervous system insults, which may result in developmental difficulties, including cerebral palsy. ..
  44. A Wireless Neural Microstimulator
    BRUCE TOWE; Fiscal Year: 2005
    ....
  45. Towards a Non-Invasive Therapy for Atrial Fibrillation
    Benjamin Scherlag; Fiscal Year: 2004
    ..This new therapeutic approach could be utilized as a non-invasive application or incorporated into an implantable device for treatment of patients with PAF. ..
  46. Gene Targets of NKX 2.5 in the Conduction System
    Melvin Scheinman; Fiscal Year: 2004
    ..MinK and HCN-1) in the pathogenesis of arrhythmias in the ventricular restricted knockout mouse model. This will be done by using in-situ hybridization and immunohistochemistry to follow the pattern of expression of these ion channels. ..
  47. Ca Handling & Arrhythmias Associated with LQT Syndrome
    KENNETH LAURITA; Fiscal Year: 2005
    ..The long term objectives of this study are to determine the mechanistic relationship between abnormal intracellular calcium handling and arrhythmias associated with LQTS (i.e. TdP). ..
  48. Norepinephrine and Nerve Growth Factor in Heart Failure
    Chang Seng Liang; Fiscal Year: 2004
    ..Our research will not only elucidate the mechanisms responsible for noradrenergic nerve ending dysfunction, but also provide a potentially useful new modality for the treatment of heart failure. ..
  49. Electrophysiologic effects of late PCI (OAT-EP)
    Stephen Shorofsky; Fiscal Year: 2005
    ....
  50. NASD Academic ED Collaborative - UC San Diego
    Theodore Chan; Fiscal Year: 2004
    ..UCSD ED investigators will be responsible for following up on difficult to reach) patients. Local data and survey results will be submitted to the R-25 and R-21 sites for analysis. ..
  51. CARDIAC MAPPING OF VENTRICULAR DEFIBRILLATION
    Raymond Ideker; Fiscal Year: 2006
    ..It is hoped that the basic knowledge gained about defibrillation mechanisms through these studies will lead to the improvement of defibrillation in patients. ..
  52. HEPATIC DRUG TRANSPORTERS IN DRUG DISPOSITION
    Dan Roden; Fiscal Year: 2006
    ..Moreover, variability in the extent of rifampin-mediated induction of the drug metabolizing enzyme, CYP3A, among subjects with variant OATP-C alleles, will also be tested. [unreadable] [unreadable]..
  53. TNF-ALPHA REGULATION OF AT1 RECEPTOR & POST-MI FIBROSIS
    Barry Greenberg; Fiscal Year: 2003
    ..This information will provide important insights into the pathogenesis of post-MI fibrosis. ..
  54. Modulation of Cardiac Mechanics in AL Amyloidosis
    Theodore Abraham; Fiscal Year: 2005
    ..The long-term goal of this research is to better understand the factors that influence the development of cardiac dysfunction in AL with the aim of optimizing treatment strategies to improve clinical outcomes in AL patients. ..
  55. NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
    Michael Givertz; Fiscal Year: 2003
    ..abstract_text> ..
  56. Cardiac Parasympathetic Effect in Exercise and Recovery
    Jeffrey Goldberger; Fiscal Year: 2006
    ..abstract_text> ..
  57. A Validated Micro-Structural Mechanical Model of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ....
  58. Pressure and Flow-Induced Remodeling of Coronary Arteries
    Ghassan S Kassab; Fiscal Year: 2010
    ..The long-term goal of this research is to develop optimal therapies to restore the oxidative balance in CAD. ..
  59. Decision Making in End-Stage Heart Failure
    Paul Hauptman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  60. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  61. ULTRASOUND-INDUCED DRUG DELIVERY THROUGH THE BLOOD-BRAIN BARRIER
    Elisa Konofagou; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..