prostatectomy

Summary

Summary: Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).

Top Publications

  1. pmc Radical prostatectomy versus observation for localized prostate cancer
    Timothy J Wilt
    Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs VA Health Care System, and Section of General Medicine, University of Minnesota School of Medicine, Minneapolis, USA
    N Engl J Med 367:203-13. 2012
  2. ncbi Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer
    A V D'Amico
    Joint Center for Radiation Therapy, Harvard Medical School, Boston, Mass 02215, USA
    JAMA 280:969-74. 1998
  3. ncbi Quality of life and satisfaction with outcome among prostate-cancer survivors
    Martin G Sanda
    Departments of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard University, Boston, MA 02215, USA
    N Engl J Med 358:1250-61. 2008
  4. ncbi Radical prostatectomy versus watchful waiting in early prostate cancer
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    N Engl J Med 364:1708-17. 2011
  5. ncbi Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience
    M Han
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urol Clin North Am 28:555-65. 2001
  6. ncbi Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial
    Eva Johansson
    Department of Surgical Sciences, University Hospital of Uppsala, Uppsala, Sweden
    Lancet Oncol 12:891-9. 2011
  7. ncbi Phase III postoperative adjuvant radiotherapy after radical prostatectomy compared with radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate-specific antigen: ARO 96-02/AUO AP 09/95
    Thomas Wiegel
    Department of Radio Oncology, University Hospital Ulm, Ulm, Germany
    J Clin Oncol 27:2924-30. 2009
  8. ncbi Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy
    Vincenzo Ficarra
    University of Padua, Padua, Italy
    Eur Urol 62:405-17. 2012
  9. pmc Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy
    Bruce J Trock
    Brady Urological Institute, Johns Hopkins School of Medicine, 600 N Wolfe St, 546 Phipps Bldg, Baltimore, MD 21287, USA
    JAMA 299:2760-9. 2008
  10. pmc Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mix
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 28:1508-13. 2010

Detail Information

Publications331 found, 100 shown here

  1. pmc Radical prostatectomy versus observation for localized prostate cancer
    Timothy J Wilt
    Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs VA Health Care System, and Section of General Medicine, University of Minnesota School of Medicine, Minneapolis, USA
    N Engl J Med 367:203-13. 2012
    ..The effectiveness of surgery versus observation for men with localized prostate cancer detected by means of prostate-specific antigen (PSA) testing is not known...
  2. ncbi Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer
    A V D'Amico
    Joint Center for Radiation Therapy, Harvard Medical School, Boston, Mass 02215, USA
    JAMA 280:969-74. 1998
    ..Interstitial radiation (implant) therapy is used to treat clinically localized adenocarcinoma of the prostate, but how it compares with other treatments is not known...
  3. ncbi Quality of life and satisfaction with outcome among prostate-cancer survivors
    Martin G Sanda
    Departments of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard University, Boston, MA 02215, USA
    N Engl J Med 358:1250-61. 2008
    ....
  4. ncbi Radical prostatectomy versus watchful waiting in early prostate cancer
    Anna Bill-Axelson
    Department of Urology, University Hospital, Uppsala, Sweden
    N Engl J Med 364:1708-17. 2011
    In 2008, we reported that radical prostatectomy, as compared with watchful waiting, reduces the rate of death from prostate cancer. After an additional 3 years of follow-up, we now report estimated 15-year results.
  5. ncbi Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience
    M Han
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urol Clin North Am 28:555-65. 2001
    ..Excellent long-term results can be obtained with RRP for early stage disease. The proportion of men with early stage prostate cancer will continue to increase with wide use of serum PSA testing and digital rectal examination...
  6. ncbi Long-term quality-of-life outcomes after radical prostatectomy or watchful waiting: the Scandinavian Prostate Cancer Group-4 randomised trial
    Eva Johansson
    Department of Surgical Sciences, University Hospital of Uppsala, Uppsala, Sweden
    Lancet Oncol 12:891-9. 2011
    ..We report results for quality of life for men in the Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) after a median follow-up of more than 12 years...
  7. ncbi Phase III postoperative adjuvant radiotherapy after radical prostatectomy compared with radical prostatectomy alone in pT3 prostate cancer with postoperative undetectable prostate-specific antigen: ARO 96-02/AUO AP 09/95
    Thomas Wiegel
    Department of Radio Oncology, University Hospital Ulm, Ulm, Germany
    J Clin Oncol 27:2924-30. 2009
    Local failure after radical prostatectomy (RP) is common in patients with cancer extending beyond the capsule. Two randomized trials demonstrated an advantage for adjuvant radiotherapy (RT) compared with a wait-and-see policy...
  8. ncbi Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy
    Vincenzo Ficarra
    University of Padua, Padua, Italy
    Eur Urol 62:405-17. 2012
    Robot-assisted radical prostatectomy (RARP) was proposed to improve functional outcomes in comparison with retropubic radical prostatectomy (RRP) or laparoscopic radical prostatectomy (LRP)...
  9. pmc Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy
    Bruce J Trock
    Brady Urological Institute, Johns Hopkins School of Medicine, 600 N Wolfe St, 546 Phipps Bldg, Baltimore, MD 21287, USA
    JAMA 299:2760-9. 2008
    Biochemical disease recurrence after radical prostatectomy often prompts salvage radiotherapy, but no studies to date have had sufficient numbers of patients or follow-up to determine whether radiotherapy improves survival, and if so, ..
  10. pmc Metastasis after radical prostatectomy or external beam radiotherapy for patients with clinically localized prostate cancer: a comparison of clinical cohorts adjusted for case mix
    Michael J Zelefsky
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 28:1508-13. 2010
    We assessed the effect of radical prostatectomy (RP) and external beam radiotherapy (EBRT) on distant metastases (DM) rates in patients with localized prostate cancer treated with RP or EBRT at a single specialized cancer center.
  11. pmc Individualized estimation of the benefit of radical prostatectomy from the Scandinavian Prostate Cancer Group randomized trial
    Andrew Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Eur Urol 62:204-9. 2012
    Although there is randomized evidence that radical prostatectomy improves survival, there are few data on how benefit varies by baseline risk.
  12. ncbi Multicenter clinical validation of PITX2 methylation as a prostate specific antigen recurrence predictor in patients with post-radical prostatectomy prostate cancer
    Lionel L Banez
    Division of Urologic Surgery and Duke Prostate Center, and Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Urol 184:149-56. 2010
    Radical prostatectomy is potentially curative in patients with clinically localized prostate cancer. However, biochemical recurrence affects 15% to 30% of men who undergo radical prostatectomy...
  13. ncbi Focal cryotherapy for clinically unilateral, low-intermediate risk prostate cancer in 73 men with a median follow-up of 3.7 years
    Duke Bahn
    Institute of Urology, Hillard and Roclyn Herzog Center for Prostate Cancer Focal Therapy, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Eur Urol 62:55-63. 2012
    ..Results of initial series of focal therapy to minimize cryosurgery-related morbidity without compromising oncologic control have been encouraging, but limited in short-term outcomes...
  14. pmc Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial
    Ian M Thompson
    University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Urol 181:956-62. 2009
    Extraprostatic disease will be manifest in a third of men after radical prostatectomy. We present the long-term followup of a randomized clinical trial of radiotherapy to reduce the risk of subsequent metastatic disease and death.
  15. ncbi Clinical-pathologic correlation between transperineal mapping biopsies of the prostate and three-dimensional reconstruction of prostatectomy specimens
    E David Crawford
    Division of Urology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA
    Prostate 73:778-87. 2013
    ....
  16. pmc Prediction of pathological and oncological outcomes based on extended prostate biopsy results in patients with prostate cancer receiving radical prostatectomy: a single institution study
    Fumio Ishizaki
    Department of Urology, Joetsu 942 8502, Japan
    Diagn Pathol 7:68. 2012
    ..outcomes based on standardized extended prostate biopsies with core histological results diagrammed/mapped in patients receiving radical prostatectomy for prostate cancer clinically diagnosed as localized or locally advanced disease.
  17. pmc TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomy
    Anuradha Gopalan
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer Res 69:1400-6. 2009
    ....
  18. ncbi Cancer control with radical prostatectomy alone in 1,000 consecutive patients
    Gerald W Hull
    Department of Urology, Medical University of South Carolina, Charleston, USA
    J Urol 167:528-34. 2002
    We analyzed the long-term progression-free probability after radical retropubic prostatectomy in a consecutive series of patients with localized prostate cancer.
  19. pmc Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy
    Andrew J Stephenson
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195 0001, USA
    J Clin Oncol 25:2035-41. 2007
    ..antigen (PSA) level is the initial sign of recurrent prostate cancer among patients treated with radical prostatectomy. Salvage radiation therapy (SRT) may eradicate locally recurrent cancer, but studies to distinguish local from ..
  20. ncbi Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    JAMA 294:433-9. 2005
    The natural history of biochemical recurrence after radical prostatectomy can be long but variable...
  21. ncbi Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trial
    Ian M Thompson
    Department of Urology, University of Texas Health Science Center at San Antonio, MC 7845, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    JAMA 296:2329-35. 2006
    ..stages and lower tumor volumes for prostate cancer, pathologically advanced disease is detected at radical prostatectomy in 38% to 52% of patients...
  22. ncbi Systematic review: comparative effectiveness and harms of treatments for clinically localized prostate cancer
    Timothy J Wilt
    University of Minnesota School of Medicine, Minneapolis Veterans Affairs Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota 55417, USA
    Ann Intern Med 148:435-48. 2008
    ..The comparative effectiveness of localized prostate cancer treatments is largely unknown...
  23. ncbi Biochemical (prostate specific antigen) recurrence probability following radical prostatectomy for clinically localized prostate cancer
    Misop Han
    James Buchanan Brady Urological Institute, Departments of Urology, Oncology and Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 169:517-23. 2003
    ..followup for a large series of men with clinically localized prostate cancer who underwent radical retropubic prostatectomy to identify clinical and/or pathological indicators of biochemical (prostate specific antigen [PSA]) ..
  24. ncbi Comparison of health-related quality of life 5 years after SPIRIT: Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial
    Juanita Mary Crook
    University of Toronto, University Health Network, and Princess Margaret Hospital, Toronto, Ontario, Canada
    J Clin Oncol 29:362-8. 2011
    The American College of Surgeons Oncology Group phase III Surgical Prostatectomy Versus Interstitial Radiation Intervention Trial comparing radical prostatectomy (RP) and brachytherapy (BT) closed after 2 years due to poor accrual...
  25. ncbi Two positive nodes represent a significant cut-off value for cancer specific survival in patients with node positive prostate cancer. A new proposal based on a two-institution experience on 703 consecutive N+ patients treated with radical prostatectomy, e
    Alberto Briganti
    Department of Urology, Vita Salute University, Milan, Italy
    Eur Urol 55:261-70. 2009
    ..However, node positive (N+) patients share heterogeneous outcomes according to the extent of lymph node invasion (LNI)...
  26. ncbi Immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy
    Edward M Messing
    Department of Urology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Lancet Oncol 7:472-9. 2006
    ..aim was to determine whether immediate ADT extends survival in men with node-positive prostate cancer who have undergone radical prostatectomy and pelvic lymphadenectomy compared with those who received ADT only once disease progressed.
  27. ncbi Preoperative prostate-specific antigen isoform p2PSA and its derivatives, %p2PSA and prostate health index, predict pathologic outcomes in patients undergoing radical prostatectomy for prostate cancer
    Giorgio Guazzoni
    Department of Urology, San Raffaele Turro, Vita Salute San Raffaele University, Milan, Italy
    Eur Urol 61:455-66. 2012
    Currently available predictive models fail to assist clinical decision making in prostate cancer (PCa) patients who are possible candidates for radical prostatectomy (RP). New biomarkers would be welcome.
  28. ncbi DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer
    Christa Haldrup
    Christa Haldrup, Kamilla Mundbjerg, Else Marie Vestergaard, Philippe Lamy, Michael Borre, Søren Høyer, Torben F Ørntoft, and Karina D Sørensen, Aarhus University Hospital, Aarhus, Denmark Peter Wild, University Hospital Zurich, Zurich, Switzerland Wolfgang A Schulz and Christian Arsov, Heinrich Heine University, Dusseldorf, Germany and Tapio Visakorpi, University of Tampere and Tampere University Hospital, Tampere, Finland
    J Clin Oncol 31:3250-8. 2013
    ..Here, we identify six novel candidate DNA methylation markers for PC with promising diagnostic and prognostic potential...
  29. pmc Secondary therapy, metastatic progression, and cancer-specific mortality in men with clinically high-risk prostate cancer treated with radical prostatectomy
    Ofer Yossepowitch
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Eur Urol 53:950-9. 2008
    ..used definitions for high-risk prostate cancer identify men at increased risk of PSA relapse after radical prostatectomy (RP)...
  30. ncbi Validation of a cell-cycle progression gene panel to improve risk stratification in a contemporary prostatectomy cohort
    Matthew R Cooperberg
    University of California, San Francisco, Box 1695, 1600 Divisadero St, A 624, San Francisco, CA 94143 1695, USA
    J Clin Oncol 31:1428-34. 2013
    We aimed to validate a previously described genetic risk score, denoted the cell-cycle progression (CCP) score, in predicting contemporary radical prostatectomy (RP) outcomes.
  31. ncbi Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911)
    Michel Bolla
    Department of Radiation Oncology, Centre Hospitalier Universitaire A Michallon, Grenoble, France
    Lancet 380:2018-27. 2012
    ....
  32. ncbi A biopsy simulation study to assess the accuracy of several transrectal ultrasonography (TRUS)-biopsy strategies compared with template prostate mapping biopsies in patients who have undergone radical prostatectomy
    Yipeng Hu
    Centre for Medical Image Computing, University College London UCL, London, UK
    BJU Int 110:812-20. 2012
    ..Adding anterior sampling improves on this but the highest accuracy is achieved using transperineal template prostate mapping using a 5 mm sampling frame...
  33. ncbi A critical analysis of the long-term impact of radical prostatectomy on cancer control and function outcomes
    Stephen A Boorjian
    Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, MN 55905, USA
    Eur Urol 61:664-75. 2012
    ..Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP).
  34. ncbi Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer
    Niall Barron
    National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    Prostate 72:1193-9. 2012
    Radical prostatectomy cures the majority of men with clinically localized disease, but up to 30% of men relapse with rising serum PSA levels...
  35. pmc An immunohistochemical signature comprising PTEN, MYC, and Ki67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomy
    Emmanuel S Antonarakis
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer 118:6063-71. 2012
    ..The authors examined PTEN and additional protein markers in primary tumors from patients with high-risk, localized prostate cancer who received adjuvant docetaxel in a prospective multicenter trial (TAX2501)...
  36. pmc Disseminated tumor cells in prostate cancer patients after radical prostatectomy and without evidence of disease predicts biochemical recurrence
    Todd M Morgan
    Department of Urology, University of Washington School of Medicine, 1959 NE Pacific, BB 1115, Box 356510, Seattle, WA 98195, USA
    Clin Cancer Res 15:677-83. 2009
    Men with apparently localized prostate cancer often relapse years after radical prostatectomy. We sought to determine if epithelial-like cells identified from bone marrow in patients after radical prostatectomy, commonly called ..
  37. ncbi Prostate cancer in Korean men exhibits poor differentiation and is adversely related to prognosis after radical prostatectomy
    Cheryn Song
    Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Urology 68:820-4. 2006
    ..To investigate the clinical and pathologic characteristics of prostate cancer in Korean men to determine how ethnic differences affect clinical outcome...
  38. ncbi Radical prostatectomy by the retropubic, perineal and laparoscopic approach: 12 years of experience in one center
    Laurent Salomon
    Department of Urology, C H U Henri MONDOR, 51 Avenue du Marechal de Lattre de Tassigny, 94010, Creteil, France
    Eur Urol 42:104-10; discussion 110-1. 2002
    We retrospectively evaluated the oncological outcome of radical prostatectomy performed by the retropubic, perineal and laparoscopic approaches.
  39. ncbi Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911)
    Michel Bolla
    Department of Radiation Oncology, Centre Hospitalier Universitaire A Michallon, Grenoble, France
    Lancet 366:572-8. 2005
    Local failure after prostatectomy can arise in patients with cancer extending beyond the capsule...
  40. ncbi ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy
    Sarah Minner
    Institute of Pathology and Departments of Clinical Chemistry, Bone Marrow Transplantation with Section, Pneumology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 17:5878-88. 2011
    ..A secondary aim was to search for differences between these tumor classes...
  41. pmc Protein-coding and microRNA biomarkers of recurrence of prostate cancer following radical prostatectomy
    Qi Long
    Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 179:46-54. 2011
    ..predictive of biochemical recurrence, we isolated the RNA from 70 formalin-fixed, paraffin-embedded radical prostatectomy specimens with known long-term outcomes to perform DASL expression profiling with a custom panel that we ..
  42. ncbi High level of androgen receptor is associated with aggressive clinicopathologic features and decreased biochemical recurrence-free survival in prostate: cancer patients treated with radical prostatectomy
    Rile Li
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Surg Pathol 28:928-34. 2004
    ..In this regard, we have correlated levels of AR expression with some well-established clinical and pathologic parameters and assessed the prognostic value of AR expression in PCa patients treated with radical prostatectomy.
  43. ncbi Laparoscopic versus open radical prostatectomy: a comparative study at a single institution
    Jens Rassweiler
    Department of Urology, Klinikum Heilbronn, University of Heidelberg, Germany
    J Urol 169:1689-93. 2003
    There is an ongoing debate about the benefits of laparoscopic radical prostatectomy compared to the open retropubic approach...
  44. pmc Prostate cancer-specific mortality after radical prostatectomy for patients treated in the prostate-specific antigen era
    Andrew J Stephenson
    Glickman Urological and Kidney Institute and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA
    J Clin Oncol 27:4300-5. 2009
    The long-term risk of prostate cancer-specific mortality (PCSM) after radical prostatectomy is poorly defined for patients treated in the era of widespread prostate-specific antigen (PSA) screening...
  45. pmc Preoperative nomogram predicting the 10-year probability of prostate cancer recurrence after radical prostatectomy
    Andrew J Stephenson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Natl Cancer Inst 98:715-7. 2006
    ..of prostate cancer recurrence, defined by prostate-specific antigen (PSA), at 5 years after radical prostatectomy based on clinical stage, serum PSA, and biopsy Gleason grade...
  46. ncbi Retropubic, laparoscopic, and robot-assisted radical prostatectomy: a systematic review and cumulative analysis of comparative studies
    Vincenzo Ficarra
    Department of Oncological and Surgical Sciences, Urology Clinic, University of Padua, Padua, Italy
    Eur Urol 55:1037-63. 2009
    Despite the wide diffusion of laparoscopic radical prostatectomy (LRP) and robot-assisted laparoscopic radical prostatectomy (RALP), only few studies comparing the results of these techniques with the retropubic radical prostatectomy (..
  47. ncbi Factors predicting early return of continence after radical prostatectomy
    Jaspreet S Sandhu
    Division of Urology, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA
    Curr Urol Rep 11:191-7. 2010
    Success of radical prostatectomy is measured by control of cancer and return of urinary and sexual function. Urinary incontinence is generally considered the greatest impairment in immediate postoperative urinary function...
  48. pmc Integration of gene expression profiling and clinical variables to predict prostate carcinoma recurrence after radical prostatectomy
    Andrew J Stephenson
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 104:290-8. 2005
    Gene expression profiling of prostate carcinoma offers an alternative means to distinguish aggressive tumor biology and may improve the accuracy of outcome prediction for patients with prostate carcinoma treated by radical prostatectomy.
  49. ncbi Clinical implications of TMPRSS2-ERG gene fusion expression in patients with prostate cancer treated with radical prostatectomy
    José Rubio-Briones
    Department of Urology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
    J Urol 183:2054-61. 2010
    ..We analyzed the association of the TMPRSS2-ERG fusion gene with prostate cancer outcome in patients treated with radical prostatectomy.
  50. ncbi The impact of prostate gland weight in robot assisted laparoscopic radical prostatectomy
    Brian A Link
    Department of Urology, City of Hope, Duarte, California, USA
    J Urol 180:928-32. 2008
    We determined whether prostate weight has an impact on the pathological and operative outcomes of robot assisted laparoscopic radical prostatectomy.
  51. ncbi Dynamic contrast enhanced, pelvic phased array magnetic resonance imaging of localized prostate cancer for predicting tumor volume: correlation with radical prostatectomy findings
    Arnauld Villers
    Department of Urology, Hospital Claude Huriez, Centre Hospitalier Regional Universitaire de Lille, 59037 Lille, France
    J Urol 176:2432-7. 2006
    ..We assessed the value of pelvic phased array dynamic contrast enhanced magnetic resonance imaging for predicting the intraprostatic location and volume of clinically localized prostate cancers...
  52. ncbi Dynamic contrast-enhanced-magnetic resonance imaging evaluation of intraprostatic prostate cancer: correlation with radical prostatectomy specimens
    Philippe Puech
    Department of Radiology, Centre Hospitalier Regional Universitaire de Lille, France
    Urology 74:1094-9. 2009
    ..identification of intraprostatic cancer foci related to cancer volume at histopathology, in patients with clinically localized cancer treated by radical prostatectomy, with whole-mount histopathologic sections as the reference standard.
  53. ncbi Pathological results and rates of treatment failure in high-risk prostate cancer patients after radical prostatectomy
    Jochen Walz
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Canada
    BJU Int 107:765-70. 2011
    To investigate the pathological characteristics and the rates of biochemical recurrence (BCR) -free survival after radical prostatectomy (RP) in men with high-risk prostate cancer.
  54. ncbi Quality of life after radical prostatectomy or watchful waiting
    Gunnar Steineck
    Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
    N Engl J Med 347:790-6. 2002
    We evaluated symptoms and self-assessments of quality of life in men with localized prostate cancer who participated in a randomized comparison between radical prostatectomy and watchful waiting.
  55. ncbi Assessment of aggressiveness of prostate cancer: correlation of apparent diffusion coefficient with histologic grade after radical prostatectomy
    Sadhna Verma
    Department of Radiology, University of Cincinnati Medical Center, 234 Goodman St, PO Box 670761, Cincinnati, OH 45267 0761, USA
    AJR Am J Roentgenol 196:374-81. 2011
    The purpose of this article is to evaluate the relationship between apparent diffusion coefficient (ADC) values, tumor volume, and total Gleason grade in patients with prostate cancer before radical prostatectomy.
  56. ncbi Pentafecta: a new concept for reporting outcomes of robot-assisted laparoscopic radical prostatectomy
    Vipul R Patel
    Global Robotics Institute, Florida Hospital Celebration Health, University of Central Florida School of Medicine, Orlando, FL 34747, USA
    Eur Urol 59:702-7. 2011
    ..Their demands and expectations of surgical intervention are much higher and cannot be adequately addressed with the classic trifecta outcome measures...
  57. ncbi Prostate cancer: 1HMRS-DCEMR at 3T versus [(18)F]choline PET/CT in the detection of local prostate cancer recurrence in men with biochemical progression after radical retropubic prostatectomy (RRP)
    Valeria Panebianco
    Dept of Radiological Sciences, Sapienza University of Rome, V le Regina Elena, 324 00161 Rome, Italy
    Eur J Radiol 81:700-8. 2012
    ..DCE-MRI) combined techniques at 3T magnet versus [(18)F]choline PET/computed tomography (CT) in the detection of local prostate cancer recurrence in patients with biochemical progression after radical retropubic prostatectomy (RRP).
  58. ncbi Long-term risk of clinical progression after biochemical recurrence following radical prostatectomy: the impact of time from surgery to recurrence
    Stephen A Boorjian
    Department of Urology, Mayo Clinic, Rochester, MN, USA
    Eur Urol 59:893-9. 2011
    The natural history of biochemical recurrence (BCR) after radical retropubic prostatectomy (RRP) is variable and does not always translate into systemic progression or prostate cancer (PCa) death.
  59. ncbi Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study
    J L Stanford
    Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle 98109 1024, USA
    JAMA 283:354-60. 2000
    ..Patients with prostate cancer and their physicians need knowledge of treatment options and their potential complications, but limited data on complications are available in unselected population-based cohorts of patients...
  60. pmc Cigarette smoking and prostate cancer recurrence after prostatectomy
    Corinne E Joshu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Natl Cancer Inst 103:835-8. 2011
    ..smoking and prostate cancer recurrence in a retrospective cohort study of 1416 men who underwent radical prostatectomy. Surgeries were performed by a single surgeon at Johns Hopkins Hospital between January 1, 1993, and March 31, ..
  61. pmc The CAPRA-S score: A straightforward tool for improved prediction of outcomes after radical prostatectomy
    Matthew R Cooperberg
    Department of Urology, University of California, San Francisco, California, USA
    Cancer 117:5039-46. 2011
    ..They aimed to develop a similar postsurgical score with improved accuracy via incorporation of pathologic data...
  62. ncbi Prostate cancer recurrence after radical prostatectomy: the role of 3-T diffusion imaging in multi-parametric magnetic resonance imaging
    Valeria Panebianco
    Department of Radiological Sciences, Oncology and Pathology, Sapienza, University of Rome, V le Regina Elena, 324, 00161 Rome, Italy
    Eur Radiol 23:1745-52. 2013
    To validate the role of 3-T diffusion-weighted imaging (DWI) in the detection of local prostate cancer recurrence after radical prostatectomy (RP).
  63. pmc The natural history of metastatic progression in men with prostate-specific antigen recurrence after radical prostatectomy: long-term follow-up
    Emmanuel S Antonarakis
    Prostate Cancer Research Program, Sidney Kimmel Comprehensive Cancer Center, Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21231, USA
    BJU Int 109:32-9. 2012
    To describe metastasis-free survival (MFS) in men with prostate-specific antigen (PSA) recurrence following radical prostatectomy, and to define clinical prognostic factors modifying metastatic risk.
  64. pmc Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers
    Ashish B Rajput
    Genetic Pathology Evaluation Centre, Vancouver General Hospital, British Columbia Cancer Agency, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Pathol 60:1238-43. 2007
    ..2) to the 3' end of either ERG (21q22.3) or ETV1 (7p21.3). The consequence of these rearrangements is aberrant androgen receptor-driven expression of the potential oncogenes, ETV1 or ERG...
  65. ncbi Expression patterns of epithelial-mesenchymal transition markers in localized prostate cancer: significance in clinicopathological outcomes following radical prostatectomy
    Hosny M Behnsawy
    Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan
    BJU Int 111:30-7. 2013
    ..patterns of multiple molecular markers implicated in epithelial-mesenchymal transition (EMT) in localized prostate cancer (PC), in order to clarify the significance of these markers in patients undergoing radical prostatectomy (RP).
  66. ncbi Preoperative pelvic floor muscle exercise for early continence after radical prostatectomy: a randomised controlled study
    Antonia Centemero
    Department of Urology, Vita Salute University, San Raffaele Turro Hospital, Milan, Italy
    Eur Urol 57:1039-43. 2010
    Despite improvements in surgical techniques, urinary incontinence (UI) is not uncommon after radical prostatectomy (RP), and it may dramatically worsen quality of life (QoL).
  67. ncbi Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer
    Alcides Chaux
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mod Pathol 25:1543-9. 2012
    ..men who recurred and 451 men who did not recur with clinically localized prostate cancer treated by radical prostatectomy. Recurrence was defined as biochemical recurrence (serum prostate-specific antigen >0...
  68. ncbi Robotic vs open prostatectomy in a laparoscopically naive centre: a matched-pair analysis
    Bernardo Rocco
    Division of Urology, European Institute of Oncology, Milan, Italy
    BJU Int 104:991-5. 2009
    To compare the early oncological, perioperative and functional outcomes of robotic-assisted radical prostatectomy (RARP) vs open retropubic RP (RRP) in a laparoscopically naive centre, as robotic assistance aids the laparoscopically ..
  69. ncbi Management of recurrent anastomotic stenosis following radical prostatectomy using holmium laser and steroid injection
    Ehab Eltahawy
    Ain Shams University Hospitals, Egypt
    BJU Int 102:796-8. 2008
    To present our experience with the management of recurrent and resistant anastomotic stenosis following radical prostatectomy (RP) using transurethral laser incision of the stenotic area and injection of steroids.
  70. ncbi Implications of the International Society of Urological Pathology modified Gleason grading system
    Lars Egevad
    Department of Pathology, Karolinska University Hospital, Stockholm, Sweden
    Arch Pathol Lab Med 136:426-34. 2012
    ..A consensus conference was organized in 2005 by the International Society of Urological Pathology (ISUP) for standardizing both the perception of histologic patterns and how the grade information is compiled and reported...
  71. ncbi Outcome predictors of radical prostatectomy in patients with prostate-specific antigen greater than 20 ng/ml: a European multi-institutional study of 712 patients
    Martin Spahn
    University Hospital Wurzburg, Department of Urology and Pediatric Urology, Germany
    Eur Urol 58:1-7; discussion 10-1. 2010
    ..Pretreatment predictors of outcome after radical prostatectomy (RP) in this patient group are necessary.
  72. pmc Determining prostate cancer-specific death through quantification of stromogenic carcinoma area in prostatectomy specimens
    Gustavo E Ayala
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Pathol 178:79-87. 2011
    ..These data substantiate the concept that the tumor microenvironment holds significant predictive information, as well as biological significance...
  73. pmc Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    W Weichert
    Institute of Pathology, Charite Universitatsmedizin, Berlin, Germany
    Br J Cancer 98:604-10. 2008
    ..Also, the highly significant prognostic value of HDAC2 clearly deserves further study...
  74. pmc Comprehensive prospective comparative analysis of outcomes between open and laparoscopic radical prostatectomy conducted in 2003 to 2005
    Karim Touijer
    Department of Surgery, Service of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 179:1811-7; discussion 1817. 2008
    In a nonrandomized prospective fashion we compared the oncological, functional and morbidity outcomes after laparoscopic and retropubic radical prostatectomy.
  75. ncbi Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results
    Kimberly A Roehl
    Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri, USA
    J Urol 172:910-4. 2004
    We updated a long-term cancer control outcome in a large anatomical radical retropubic prostatectomy (RRP) series. We also evaluated the perioperative parameters that predict cancer specific outcomes following surgery.
  76. ncbi Preoperative PSA velocity and the risk of death from prostate cancer after radical prostatectomy
    Anthony V D'Amico
    Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, USA
    N Engl J Med 351:125-35. 2004
    We evaluated whether men at risk for death from prostate cancer after radical prostatectomy can be identified using information available at diagnosis.
  77. ncbi Is radical prostatectomy feasible in all cases of locally advanced non-bone metastatic prostate cancer? Results of a single-institution study
    Paolo Gontero
    Clinica Urologica I, Universita degli Studi di Torino, Torino, Italy
    Eur Urol 51:922-9; discussion 929-30. 2007
    ..The aim of the present study was to assess the feasibility and the oncologic outcome of radical prostatectomy administered to a consecutive unselected series of advanced, non-bone metastatic prostate cancers.
  78. ncbi Phase II trial of celecoxib in prostate-specific antigen recurrent prostate cancer after definitive radiation therapy or radical prostatectomy
    Raj S Pruthi
    Division of Urologic Surgery, Department of Biostatistics, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Clin Cancer Res 12:2172-7. 2006
    ..However, human trials are absent. This study evaluated the efficacy of the COX-2 inhibitor celecoxib in prostate-specific antigen (PSA) recurrent prostate cancer after radiation therapy (X-ray therapy or XRT) or radical prostatectomy.
  79. pmc The University of California, San Francisco Cancer of the Prostate Risk Assessment score: a straightforward and reliable preoperative predictor of disease recurrence after radical prostatectomy
    Matthew R Cooperberg
    University of California, San Francisco, San Francisco, USA
    J Urol 173:1938-42. 2005
    ..We devised a novel risk assessment tool which would be a strong predictor of outcome across various levels of risk, and which could be easily applied and intuitively understood...
  80. pmc Gene panel model predictive of outcome in men at high-risk of systemic progression and death from prostate cancer after radical retropubic prostatectomy
    John C Cheville
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 26:3930-6. 2008
    In men who are at high-risk of prostate cancer, progression and death from cancer after radical retropubic prostatectomy (RRP), limited prognostic information is provided by established prognostic features...
  81. ncbi Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis
    Barbara Biki
    Department of Anaesthesia, Mater Misericordiae University Hospital, The Cleveland Clinic, USA
    Anesthesiology 109:180-7. 2008
    ..Therefore, the authors evaluated prostate cancer recurrence in patients who received either general anesthesia with epidural anesthesia/analgesia or general anesthesia with postoperative opioid analgesia...
  82. ncbi Prognostic significance of tumor volume in radical prostatectomy and needle biopsy specimens
    Jonathan I Epstein
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    J Urol 186:790-7. 2011
    ..This review addresses the controversies that persist relating to the prognosis and reporting of tumor volume in adenocarcinoma of the prostate...
  83. ncbi Artificial urinary sphincter for post-radical prostatectomy urinary incontinence: long-term subjective results
    A E Gousse
    Urology Department, University of Miami, Jackson's Memorial Hospital, Miami, Florida, USA
    J Urol 166:1755-8. 2001
    PURPOSE: Incontinence affects between 3% and 60% of patients after radical prostatectomy. Insertion of an artificial urinary sphincter is a mainstay therapeutic option available to these patients...
  84. ncbi Mid-term evaluation of the transobturator male sling for post-prostatectomy incontinence: focus on prognostic factors
    Jean Nicolas Cornu
    Department of Urology, Tenon Hospital, Groupe Hospitalo Universitaire EST, Assistance Publique Hopitaux de Paris, University Paris VI, Paris, France
    BJU Int 108:236-40. 2011
    To assess clinical outcomes at mid-term follow-up and determine preoperative factors associated with the failure of the Advance(TM) male sling for post-prostatectomy incontinence (PPI).
  85. ncbi Health outcomes after prostatectomy or radiotherapy for prostate cancer: results from the Prostate Cancer Outcomes Study
    A L Potosky
    Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
    J Natl Cancer Inst 92:1582-92. 2000
    Radical prostatectomy and external beam radiotherapy are the two major therapeutic options for treating clinically localized prostate cancer...
  86. ncbi Endorectal magnetic resonance imaging at 1.5 Tesla to assess local recurrence following radical prostatectomy using T2-weighted and contrast-enhanced imaging
    Stefano Cirillo
    Unit of Radiology, Institute for Cancer Research and Treatment, Candiolo, Torino, Italy
    Eur Radiol 19:761-9. 2009
    ..resonance (eMR) for diagnosing local recurrence of prostate cancer (PC) in patients with previous radical prostatectomy (RP) and to assess whether contrast-enhanced (CE)-eMR improved diagnostic accuracy in comparison to unenhanced ..
  87. ncbi A prospective trial comparing consecutive series of open retropubic and robot-assisted laparoscopic radical prostatectomy in a centre with a limited caseload
    Giovanni B Di Pierro
    Klinik für Urologie, Luzerner Kantonsspital, Lucerne, Switzerland
    Eur Urol 59:1-6. 2011
    Robot-assisted radical prostatectomy (RALP) is performed worldwide, even in institutions with limited caseloads...
  88. ncbi A prospective study evaluating the efficacy of the artificial sphincter AMS 800 for the treatment of postradical prostatectomy urinary incontinence and the correlation between preoperative urodynamic and surgical outcomes
    Flavio Trigo Rocha
    Division of Urology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Urology 71:85-9. 2008
    ..the long-term efficacy of the artificial urinary sphincter (AUS) AMS 800 for the treatment postradical prostatectomy urinary incontinence (PRPUI) patients...
  89. ncbi Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy: a randomized, placebo-controlled, double-blind Phase 2 clinical trial
    Bato Lazarevic
    Department of Urology, Oslo University Hospital, Oslo, Norway
    Nutr Cancer 63:889-98. 2011
    ..were recruited and randomized to treatment with genistein (n = 23) or placebo (n = 24) for 3 to 6 wk prior to prostatectomy. Seven study subjects were noncompliant to the study protocol. Adverse events were few and mild...
  90. pmc Contemporary risk profile of prostate cancer in the United States
    Yu Hsuan Shao
    Department of Population Science, Cancer Institute of New Jersey, New Brunswick, NJ, USA
    J Natl Cancer Inst 101:1280-3. 2009
    ..In conclusion, more men were diagnosed with prostate cancer at a younger age and earlier stage in 2004-2005 than in earlier years. The racial disparity in cancer stage at diagnosis has decreased statistically significantly over time...
  91. ncbi Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy?
    F Abdollah
    Department of Urology, San Raffaele Hospital, Vita Salute University, Milan, Italy
    Prostate Cancer Prostatic Dis 14:74-8. 2011
    The objective was to test the hypothesis that in patients with prostate cancer undergoing radical prostatectomy (RP), diabetic patients are at a higher risk of harboring a high-grade tumor than non-diabetic patients...
  92. pmc Active surveillance compared with initial treatment for men with low-risk prostate cancer: a decision analysis
    Julia H Hayes
    Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    JAMA 304:2373-80. 2010
    ..Treatment of these cancers is associated with substantial morbidity. Active surveillance is an alternative to initial treatment, but long-term outcomes and effect on quality of life have not been well characterized...
  93. ncbi Complete periprostatic anatomy preservation during robot-assisted laparoscopic radical prostatectomy (RALP): the new pubovesical complex-sparing technique
    Anastasios D Asimakopoulos
    Division of Urology, Department of Surgery, Policlinico Tor Vergata, University of Tor Vergata, Rome, Italy
    Eur Urol 58:407-17. 2010
    ..ligament preservation has been proposed as a method to accelerate continence recovery after radical prostatectomy (RP)...
  94. ncbi Endoscopic extraperitoneal radical prostatectomy: the University of Leipzig experience of 2000 cases
    Jens Uwe Stolzenburg
    Department of Urology, University of Leipzig, Germany
    J Endourol 22:2319-25. 2008
    Review of experience with endoscopic extraperitoneal radical prostatectomy (EERPE) for localized prostate cancer.
  95. ncbi Prognostic value of surgical margin status for biochemical recurrence following radical prostatectomy
    Kohei Hashimoto
    Department of Urology, Sapporo Medical University School of Medicine, S1, W16, Chuo Ku, Sapporo 060 8543, Japan
    Jpn J Clin Oncol 38:31-5. 2008
    We evaluated the preoperative parameters to predict a positive surgical margin (SM) at radical prostatectomy for patients with prostate cancer...
  96. ncbi Impact of extent of lymphadenectomy on survival after radical prostatectomy for prostate cancer
    Sue A Joslyn
    Division of Health Promotion and Education, University of Northern Iowa, Cedar Falls, Iowa, USA
    Urology 68:121-5. 2006
    Controversy exists regarding the benefit of extended lymphadenectomy at radical prostatectomy for prostate cancer...
  97. ncbi Comparison of operative and functional outcomes of laparoscopic radical prostatectomy and radical retropubic prostatectomy: single surgeon experience
    Reza Ghavamian
    Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Urology 67:1241-6. 2006
    To compare radical retropubic prostatectomy (RRP) and laparoscopic radical prostatectomy (LRP) outcomes in a contemporary series.
  98. ncbi Impact of body mass index on outcomes after robot assisted radical prostatectomy
    Erik P Castle
    Center for Minimally Invasive Urologic Surgery, Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA
    World J Urol 26:91-5. 2008
    ..and perioperative parameters and surgical margin rates, in patients who underwent robotic assisted radical prostatectomy (RARP).We retrospectively reviewed 140 consecutive RARPs performed by the same surgical team...
  99. ncbi Robotic-assisted laparoscopic and radical retropubic prostatectomy generate similar positive margin rates in low and intermediate risk patients
    Timo A J Laurila
    Division of Urology, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53972, USA
    Urol Oncol 27:529-33. 2009
    Robotic-assisted laparoscopic prostatectomy (RALP) is being increasingly utilized...
  100. ncbi Long-term outcome after radical prostatectomy for patients with lymph node positive prostate cancer in the prostate specific antigen era
    Stephen A Boorjian
    Department of Urology and Division of Biostatistics, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55905, USA
    J Urol 178:864-70; discussion 870-1. 2007
    ..We examined the impact of lymph node metastases on the outcome of patients following radical prostatectomy and investigated prognostic factors that affect survival.
  101. pmc The surgical learning curve for laparoscopic radical prostatectomy: a retrospective cohort study
    Andrew J Vickers
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Lancet Oncol 10:475-80. 2009
    We previously reported the learning curve for open radical prostatectomy, reporting large decreases in recurrence rates with increasing surgeon experience...

Research Grants74

  1. Roles of RhoA/Rho-kinase Signaling in Cavernous Neurons Following Axonal Injury
    TRINITY JUDE BIVALACQUA; Fiscal Year: 2013
    ..Urinary incontinence following radical prostatectomy (RP) has been greatly reduced;however, neurogenic-ED following "nerve-sparing" RP persists...
  2. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2011
    ..of a green tea supplement (Polyphenon E) equivalent to 6 cups of GT or 6 cups of BT for 8 weeks prior to prostatectomy will decrease oxidative stress, alter signaling pathways leading to an inhibition of proliferation and ..
  3. Adiposity and Outcomes of Clinically Localized Prostate Cancer
    Vincent L Freeman; Fiscal Year: 2013
    ..with pathologic tumor features at diagnosis and 2-year risk of biochemical (PSA) failure after radical prostatectomy;Aim 2) measure fatty acids, insulin-like growth factor (IGF) axis activity, modulators of inflammation, and ..
  4. Exploring the Impact of Negative Energy Balance in Men with Prostate Cancer
    Wendy Demark-Wahnefried; Fiscal Year: 2013
    ..study among 40 overweight or obese men newly diagnosed with prostate cancer who are scheduled for prostatectomy. This study will capitalize on our experience of using the presurgical period to explore the potential impact ..
  5. Biological &Environmental Mediators of Vitamin D and Aggressive Prostate Cancer
    ADAM BRYANT MURPHY; Fiscal Year: 2013
    ..vitamin D as a proxy for intra-prostatic vitamin D levels using the expressed prostatic secretion from 260 prostatectomy specimen;2) estimate the effect of vitamin D on rates of proliferation and apoptosis in 240 prostate tumors by ..
  6. The role of VEGF-C in resisting stress in prostate cancer
    Kaustubh Datta; Fiscal Year: 2013
    ..of VEGF-C and their down-stream targets with the frequency of recurrence of human prostate cancer following prostatectomy. The association of high VEGF-C expression levels with cancer recurrence following prostatectomy will be ..
  7. A Prospective Study of Diet and Prostate Cancer
    Edward Giovannucci; Fiscal Year: 2011
    ..other modifiable risk factors can, in the post-diagnostic period, influence survival among men treated with prostatectomy for apparently organ-confined prostate cancer...
  8. Biomarker Prediction of Gleason Upgrading
    Bruce J Trock; Fiscal Year: 2010
    ..We propose to develop and validate the biomarker panel to identify Gleason upgrading in the prostatectomy specimen through a stepwise process...
  9. Quercetin to enhance the bioavailability and activity of green tea polyphenols
    SUSANNE MARGARETE HENNING; Fiscal Year: 2013
    ..In our previous human intervention study in men drinking 6 cups of green tea daily prior to prostatectomy we demonstrated that GTPs are present in human prostate tissue...
  10. Validation of Biomarkers to Distinguish Aggressive from Indolent Prostate Cancer
    George Wilding; Fiscal Year: 2013
    ..low grade PCa, high grade PCa and metastatic PCa available at our Institution along with patient biopsy and prostatectomy samples obtained from the Marshfield Clinic, Marshfield, WI...
  11. Proximal Prostate Fluids for Protein and miRNA Biomarkers
    Richard R Drake; Fiscal Year: 2010
    ..an existing biorepository of EPS urine samples, as well as more pure prostatic fluids obtained prior to prostatectomy. Over 250 EPS urines from healthy clinic controls, benign prostatic disease, and risk stratified prostate ..
  12. [F18]FMAU in Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ..Approximately 30% of men with detectable serum prostate-specific antigen (PSA) levels after curative radical prostatectomy have local recurrences while about 40% are expected to have distant disease...
  13. Improving Urinary Continence and Quality of Life in Prostate Cancer Patients
    Amy Y Zhang; Fiscal Year: 2012
    ..the most common cancer diagnosis in men - incidence of urinary incontinence (UI) resulting from radical prostatectomy is reported to be as high as 87%...
  14. Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
    Kathryn Radabaugh Nightingale; Fiscal Year: 2013
    ..standard of care has a dismal sensitivity (only 53% using octant systematic biopsy in a cohort of radical prostatectomy specimens with previously diagnosed, clinically significant disease, [5]), mainly because the sampling grid ..
  15. Energy Balance-Related Hormones &Prostate Cancer Incidence &Progression
    Edward Giovannucci; Fiscal Year: 2012
    ..6,085 new cases of prostate cancer by 2010, including 668 fatal cases, with tumor blocks from over 1,900 prostatectomy cases...
  16. Loss of Filamin A Nuclear Localization in Prostate Cancer Progression
    Paramita M Ghosh; Fiscal Year: 2013
    ..in VA patients with metastatic prostate cancer on androgen withdrawal therapy who did not undergo radical prostatectomy. We have identified patients within the VA Northern California System who presented with metastatic prostate ..
  17. Zinc-Based Early Detection of Prostate Cancer
    Christopher J Frederickson; Fiscal Year: 2010
    ..The subjects in this study will be (i) men scheduled for prostatectomy (ii) men scheduled for cysto-prostatectomy (iii) men scheduled for saturation (64 core) needle biopsy and (iv) ..
  18. Modular internalizing molecules for treatment of more than one stage of malignanc
    Michael Lawrence Greenberg; Fiscal Year: 2010
    ..unmet medical need for development of an effective adjunct therapy for prostate cancer either before or after prostatectomy. During this proposed Phase I research program, we will use b3 bio's core technology to identify RNA ..
  19. FOXO: A Target for Prostate Cancer Prevention
    Sanjeev Shukla; Fiscal Year: 2010
    ..The chronic inflammatory lesions frequently observed in prostate tissue biopsies and radical prostatectomy specimens are consequence to the aging process and precursor to prostate cancer development...
  20. Nitric Oxide/cGMP Modulation of Corporal Fibrosis Caused by Neuropraxia
    MONICA GABRIELA FERRINI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Erectile dysfunction (ED) is a common complication after radical prostatectomy (RP) for prostate cancer and is due to the injury of the cavernosal nerve during surgery...
  21. Role of Inflammation and Epigenetics in Benign Prostate Pathology
    Charles J Bieberich; Fiscal Year: 2012
    ..In parallel, human patient material from open prostatectomy and radical prostatectomy cases with inflammation will be characterized...
  22. Genetic &epigenetic analysis of angiogenesis genes in recurrent prostate cancer
    Jong Y Park; Fiscal Year: 2012
    ..study involves (1) construction of a historical cohort of prostate cancer cases (n=~1300) treated with radical prostatectomy at the H...
  23. Vitamin D3 Supplementation for Low-Risk Prostate Cancer: A Randomized Trial
    Sebastiano Gattoni-Celli; Fiscal Year: 2013
    ..cores and in Gleason score at repeat biopsy, and a decreased likelihood of undergoing definitive treatment (prostatectomy or radiation therapy), compared to Veteran subjects taking placebo (control group)...
  24. Profiling and Characterizing Prostate Cancer Tumor Dormancy in the Bone Marrow
    ROBERT LOUIS VESSELLA; Fiscal Year: 2010
    ..tumor cells (DTC) are present in 45% of patients with no evidence of disease (NED) >5 years after radical prostatectomy (RP)...
  25. Human Prostate Cancer Metastasis and Laminin Binding Integrins
    Anne E Cress; Fiscal Year: 2013
    ..The therapeutic strategy would consist of ablation of the primary lesion using radiotherapy and/or prostatectomy coupled with prophylactic anti-integrin antibodies or peptide combinations to eliminate osseous sanctuary ..
  26. Modulation of antitumor immunity by dietary soy and its isoflavone constituents
    Gregory B Lesinski; Fiscal Year: 2013
    ..dietary intervention with soy bread (experimental arm) or wheat bread (control arm) for 4 weeks prior to prostatectomy to evaluate pro-inflammatory cytokines, immune cell markers (e.g...
  27. In vivo feasibility of a peripheral nerve imaging agent
    Stephen B Kahl; Fiscal Year: 2013
    ..is an injectable imaging agent that may be given pre-operatively to assist surgeons prior to beginning a prostatectomy. To show feasibility we selected two NIR dyes, Alexa Fluor 790 and Dyomics 831 because their chemistries (1) ..
  28. Mitochondrial Genetics in Prostate Cancer Health Disparity
    John A Petros; Fiscal Year: 2012
    ..specimens (including peripheral blood DNA) and clinical data on over 1000 men that have undergone radical prostatectomy for prostate cancer at Emory University Hospital...
  29. Glycan Biomarkers of Prostate Cancer in Prostatic Fluids
    Richard R Drake; Fiscal Year: 2012
    ..Identification of these molecular markers will improve prostate cancer detection and risk stratification prior to biopsy and prostatectomy procedures.
  30. Prostate Cancer Recovery Enhancement (PROCARE) for African American Men
    Lisa C Campbell; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Challenging sexual, urinary, and bowel symptoms are common after radical prostatectomy for prostate cancer and often persist well beyond the acute treatment and recovery period...
  31. Super-Zoom Endoscope (SuZE)
    MIKHAIL A GUTIN; Fiscal Year: 2010
    ..ureteroscopy, lithotripsy, transurethral bladder tumor resection, bladder biopsies, fulguration, and radical prostatectomy. A broader range of applications is in gastrointestinal endoscopy, gynecologic endoscopy, arthroscopy, ..
  32. In Vivo Efficacy of Multi-Targeted Androgen Inhibition as Prostate Cancer Therapy
    Elahe A Mostaghel; Fiscal Year: 2010
    ..Prostate samples obtained at diagnosis and prostatectomy will be assayed for treatment efficacy based on androgen levels, histological measures of tissue response, and ..
  33. In vivo effects of sulforaphane supplementation on normal human prostate
    Daniel W Lin; Fiscal Year: 2013
    ..low-grade prostate cancer, and use prostate tissue collected at both the time of diagnosis (biopsy) and prostatectomy to assess carefully selected and evaluated measures of phase II detoxifying enzyme induction, intra-prostatic ..
  34. A Platform for Cancer Biomarker Validation: Image Fusion Using NIR Fluorescence
    Ali Kamen; Fiscal Year: 2013
    ..Through the Hershey Tissue Bank, men undergoing radical prostatectomy for prostate cancer receive a preoperative endorectal coil 3T MRI (pre- and post-Gd DCE), and at prostatectomy,..
  35. Effectiveness of Early Stage Prostate Cancer Treatment
    MARTIN G contact SANDA; Fiscal Year: 2010
    ..of cost-effectiveness comparing the 3 most common contemporary treatments for early stage prostate cancer: prostatectomy, external radiotherapy, and brachytherapy...
  36. Prognostic value of AR mutation in primary African American prostate cancer
    Shahriar Koochekpour; Fiscal Year: 2011
    ..In addition, in a set of 41 radical prostatectomy samples (25 AAs and 16 CAs), we identified 4 AR mutations, 3 somatic and 1 germline in AA patients...
  37. Prostate Cancer: Transition to Androgen - Independence (CA77739)
    James L Mohler; Fiscal Year: 2013
    ..A unique human prostate xenograft model that utilizes fresh tissue from radical prostatectomy specimens has been developed that allows for the study of AR action in the prostate microvasculature, and the ..
  38. ProstaFluor FDA Trial for Real-Time Margin Detection During Prostatectomy
    David A Benaron; Fiscal Year: 2013
    ..We expect that the market for such a device in cancer could reasonably be in the hundreds of millions of dollars/year. Form SF-424 Abstract ..
  39. Gene-Based Imaging and Therapy to Target Metastatic Prostate Cancer
    Lily Wu; Fiscal Year: 2012
    ..However, among patients who undergo prostatectomy with curative intent, 20 to 30% will suffer from disease recurrence as defined by serum PSA elevation...
  40. Comparative Effectiveness of Localized Prostate Cancer Treatments (Pilot Study)
    Austin B Frakt; Fiscal Year: 2013
    ..sample, we will estimate a model of prostate cancer treatment across the main treatment modalities: radical prostatectomy (RP), external beam radiation therapy (EBRT), brachytherapy (BT), and active surveillance (AS)...
  41. Single Molecule Fiber Arrays for the Detection of Low Abundance Proteins
    David C Duffy; Fiscal Year: 2013
    ..samples, specifically to measure the levels of PSA in prostate cancer patients who have undergone radical prostatectomy. Current technologies cannot detect PSA in these samples;this technology could enable the early detection of ..
  42. Molecular Imaging with FACBC PET-CT to Improve Post prostatectomy Radiotherapy
    DAVID MICHAEL SCHUSTER; Fiscal Year: 2013
    ..Approximately 50% of patients who have undergone post-prostatectomy radiotherapy after Prostate Specific Antigen (PSA) failure or biopsy proven prostate bed recurrence manifest ..
  43. MicroRNAs and Early Prostate Cancer Detection
    Alicia C McDonald; Fiscal Year: 2013
    ..mean fold difference to no prostate cancer men in Aim 1) in plasma specimen at pre- to 3-month post-radical prostatectomy in a cohort of biopsied-confirmed, localized prostate cancer men (n=50)...
  44. External validation of GEMCaP, a prognostic DNA biomarker set for CaP recurrence
    Pamela L Paris; Fiscal Year: 2013
    ..e. prostatectomy or radiation) and that metastasis is strongly associated with cancer-specific mortality...
  45. Detecting Prostate Cancer using multi-protocol 3 Tesla in vivo MRI and MRS
    Anant Madabhushi; Fiscal Year: 2009
    ..before and multi-protocol 3 T ex vivo MRI/MRSI scans with accompanying whole mount histological sections after prostatectomy will be obtained (Aim 1)...
  46. Comparative Analysis of Surgical Treatment Options for Localized Prostate Cancer
    James A Eastham; Fiscal Year: 2010
    ..Radical prostatectomy (RP) by open or minimally invasive techniques is the most common treatment for localized prostate cancer...
  47. Vitamin D3 alters stromal-epithelial inflammatory crosstalk in human prostate
    Larisa Nonn; Fiscal Year: 2013
    ..Toronto) wre given 400IU, 10,000IU or 40,000IU of vitamin D3 (cholecalciferol) for 4-6 weeks prior to radical prostatectomy. Our preliminary work focused on prostatic epithelium, however, prostatic epithelial glands are surrounded by ..
  48. Ultrasound-Guided Navigation in Robot-Assisted Laparoscopic Radical Prostatectomy
    Dan Stoianovici; Fiscal Year: 2010
    ..Early stage prostate cancer is potentially cured by radiation therapy or surgery, also known as radical prostatectomy. Radical prostatectomy can be performed in a traditional, open fashion or laparoscopically...
  49. Mechanisms of Prostate Cancer Dormancy in the Bone Marrow Niche
    Russell S Taichman; Fiscal Year: 2013
    ..Because Mr. W. was in otherwise excellent health, he chose to undergo a radical retro pubic prostatectomy and his prostate was removed. All of his lymph nodes were negative for cancer...
  50. A MULTILEVEL APPROACH TO ENERGY BALANCE AND CANCER ACROSS THE LIFECOURSE
    Graham A Colditz; Fiscal Year: 2013
    ..Study the role of physical activity and obesity in post-prostatectomy urinary and sexual function; 3...
  51. Immune-inflammatory signaling and hormone-refractory prostate cancer evolution.
    Jun Li Luo; Fiscal Year: 2013
    ..In tumors confined to the prostate, radical prostatectomy and radiotherapy are effective. However, no effective treatments are available for hormone-refractory PCa...
  52. The role of long non-coding RNA SChLAP-1 in prostate cancer
    Anirban Sahu; Fiscal Year: 2013
    ..gene expression signatures associated with poor patient outcomes and this was confirmed in a large cohort of prostatectomy patients with long-term follow-up;SChLAP-1 expression independently predicts metastasis and prostate cancer-..
  53. Gene Networks for Prostate Cancer Progression
    Leif Peterson; Fiscal Year: 2005
    ..indicator of clinical metastatic disease is a high Gleason score (>7) in tissue during radical retropubic prostatectomy (RPP) and short doubling time (<10 months) for serum prostate specific antigen (PSA)...
  54. Measuring the Impact of the Rapid Expansion of MIST Procedures for BPH
    ALEXANDER M MCBEAN; Fiscal Year: 2010
    ..The traditional, `gold standard', surgical treatment is transuretheral prostatectomy (TURP)...
  55. Validation of prognostic and pathway signatures in lethal prostate cancer
    Susan Halabi; Fiscal Year: 2013
    ..We will first comprehensively assay a retrospective cohort of 200 men who have had prostatectomy, have frozen and paraffin embedded tissue available, and have mature clinical follow up...
  56. Nerve-Specific Near-Infrared Fluorescent Contrast Agents for Image-Guided Surgery
    SUMMER LYNNE GIBBS; Fiscal Year: 2013
    ..sparing of the inferior hypogastric plexus and cavernous nerve is of paramount importance during radical prostatectomy. Male potency and urinary continence is dependent on proper functioning of these nerves...
  57. Integrating Quantitative Histological Image and Vascular Density Patterns for Pro
    Anant Madabhushi; Fiscal Year: 2010
    ..and micro-vasculature network patterns on whole mount histology sections (WMHS) obtained via radical prostatectomy (RP) to predict prostate cancer recurrence. The proposed work comprises a total of 3 specific aims...
  58. Targeted Fluorescence Imaging of Nerves for Surgical Guidance
    CRISTINA TAN HEHIR; Fiscal Year: 2013
    ..damage remains high in a wide array of prominent open and minimally invasive surgeries, ranging from radical prostatectomy (prostate cancer), coro- nary artery bypass graft (cardiovascular disease), lymph node dissection (breast ..
  59. Inhibiting serine protease-induced prostate cancer progression
    Evette S Radisky; Fiscal Year: 2013
    ..protease PRSS3/mesotrypsin as a molecule that is prognostic for prostate cancer systemic progression following prostatectomy, and that is upregulated in metastatic prostate cancer tissue...
  60. Genetic Susceptibility for Prostate Cancer Progression
    William Isaacs; Fiscal Year: 2009
    ..S;about one half will undergo radical prostatectomy (RP) for treatment of their disease...
  61. Testing Fluorescently Labeled Probes for Nerve Imaging during Surgery
    Quyen Nguyen; Fiscal Year: 2013
    ..of head and neck surgery and prostate surgery to test the surgical outcome using fluorescence labeling of nerves with the aim toward eventual use of NP41 during head and neck surgery and nerve-sparing radical prostatectomy in patients.
  62. Intraoperative Surgical Margin Assessment with Electrical Impedance Spectroscopy
    RYAN JOSEPH HALTER; Fiscal Year: 2013
    ..Instead, margins are evaluated through pathological assessment of the prostate following radical prostatectomy (RP), when it is too late to provide additional surgical intervention...
  63. Prostate MRI and MRS: Correlations with Gene Expression
    Sandra Gaston; Fiscal Year: 2007
    ..for de novo synthesis of choline containing membrane lipids) in tissue-print micro-peels obtained from radical prostatectomy specimens containing Gleason grade 6,7 or 8 prostate cancer...
  64. PERIOPERATIVE TELEHEALTH PROGRAM FOR POST-PROSTATECTOMY INCONTINENCE
    Patricia Goode; Fiscal Year: 2009
    ..The most common treatment is radical prostatectomy. A national patient survey indicated that 31% of men were still using absorbent pads 1 year after ..
  65. GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTS
    Candace Johnson; Fiscal Year: 2009
    ..Calcitriol/dex antitumor effects were also noted in men with localized disease with a rising PSA following prostatectomy or irradiation...
  66. Targeted prostate biopsy using mathematical optimization
    Christos Davatzikos; Fiscal Year: 2007
    ..has led to several computer simulation studies that utilize whole-mounted histological stained sections from prostatectomy specimens in order to estimate the performance of different biopsy approaches...
  67. Differential Gene Expression Induced by Antioxidants
    Jeri Kim; Fiscal Year: 2004
    ..alpha-tocopherol (vitamin E), singly and in combination, in normal and cancerous prostate cells from radical prostatectomy specimens using laser capture microdissection (LCM) and oligonucleotide microarrays; and 2) to validate ..
  68. PREVENTION OF DNA OXIDATION BY TOCOPHEROL & CAROTENOIDS
    Richard van Breemen; Fiscal Year: 2000
    ..Measurement of DNA oxidation in both peripheral blood cells and in prostate tissue (following prostatectomy) of the same human subjects will permit the evaluation of the predictive value of using the more easily ..
  69. Computer Directed Photodynamic Therapy of Prostate Ca
    Jerzy Jankun; Fiscal Year: 2005
    ..Treatment of organ confined prostatic cancer includes radical prostatectomy, radiotherapy, brachytherapy and cryosurgical ablation...
  70. PORT-II FOR PROSTATIC DISEASES
    Michael Barry; Fiscal Year: 1999
    ..better define the effectiveness of aggressive treatment of clinically localized prostate cancer with radical prostatectomy or radiation therapy, and to define and optimize outcomes for men with prostatic diseases seen in primary care ..
  71. PHASE II TRIAL OF SOY PRIOR TO RADICAL PROSTATECTOMY
    Maarten Bosland; Fiscal Year: 2007
    ..localized prostate cancer with administration of soy protein isolate in the 4-6 weeks prior to radical prostatectomy. The placebo will be a casein-based preparation; both preparations are identical in composition except for the ..
  72. Bioavailability of Tea Polyphenols in Prostate Cancer
    Susanne Henning; Fiscal Year: 2002
    ..to black tea and a green tea extract dietary supplement in men with prostate cancer before the time of prostatectomy. The serum will be also used to study the in vitro growth inhibiting effect in androgen-dependent LNCaP and ..
  73. PROSTATE CANCER--FAMILY CARE FOR PATIENTS AND SPOUSES
    Laurel Northouse; Fiscal Year: 2005
    ..Dyads will be stratified by three phases of illness: 1) newly diagnosed-localized phase, following prostatectomy or radiation therapy, 2) post-primary treatment phase with rising PSA (biochemical recurrence), and 3) ..
  74. Urinary Incontinence in Older Men Post Prostatectomy
    Joanne Robinson; Fiscal Year: 2006
    ..on pelvic muscle strength, a modifiable physiologic factor, in men at risk of persistent UI following radical prostatectomy. PME training will be provided during the early post-operative period through usual care vs. basic vs...