bone marrow transplantation

Summary

Summary: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

Top Publications

  1. ncbi Bone marrow cells regenerate infarcted myocardium
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, NIH, Bethesda, MD 20892, USA
    Nature 410:701-5. 2001
  2. pmc Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    Luis A Ortiz
    Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:8407-11. 2003
  3. ncbi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    T Asahara
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 85:221-8. 1999
  4. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
  5. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
  6. ncbi A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    Chloe James
    INSERM U362, Institut Gustave Roussy, Paris XI University, PR1, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Nature 434:1144-8. 2005
  7. ncbi Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
    W S Pear
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA
    Blood 92:3780-92. 1998
  8. ncbi Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    Ryota Uemura
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Circ Res 98:1414-21. 2006
  9. ncbi Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial
    Eriko Tateishi-Yuyama
    Department of Medicine II and Cardiovascular Centre, Kansai Medical University, Osaka, Japan
    Lancet 360:427-35. 2002
  10. ncbi Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999

Research Grants

  1. Sogol Mostoufi-Moab; Fiscal Year: 2016
  2. MERVYN N WEITZMANN; Fiscal Year: 2016
  3. Patrick Cahan; Fiscal Year: 2016
  4. KATHERINE YUDEH KING; Fiscal Year: 2014
  5. Development of a Pediatric Mylelodysplastic Syndrome Patient Registry
    DAVID A contact WILLIAMS; Fiscal Year: 2010
  6. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
  7. Oliver W Press; Fiscal Year: 2014
  8. Macrophage-based Human Gene Therapy for Hereditary PAP
    Bruce C Trapnell; Fiscal Year: 2012
  9. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
  10. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012

Detail Information

Publications429 found, 100 shown here

  1. ncbi Bone marrow cells regenerate infarcted myocardium
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, NIH, Bethesda, MD 20892, USA
    Nature 410:701-5. 2001
    ..The developing tissue comprised proliferating myocytes and vascular structures. Our studies indicate that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease...
  2. pmc Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    Luis A Ortiz
    Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:8407-11. 2003
    ..Collectively, these studies demonstrate that murine MSCs home to lung in response to injury, adopt an epithelium-like phenotype, and reduce inflammation and collagen deposition in lung tissue of mice challenged with BLM...
  3. ncbi Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    T Asahara
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Circ Res 85:221-8. 1999
    ..Mouse syngeneic colon cancer cells (MCA38) were implanted subcutaneously into Flk-1/LZ/BMT (bone marrow transplantation) and Tie-2/LZ/BMT mice; tumor samples harvested at 1 week disclosed abundant flk-1/lacZ and tie-2/lacZ ..
  4. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
    ..As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases...
  5. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
    ..Under conditions of stress, restricted cell cycling is crucial to prevent premature stem cell depletion and hematopoietic death...
  6. ncbi A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    Chloe James
    INSERM U362, Institut Gustave Roussy, Paris XI University, PR1, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Nature 434:1144-8. 2005
    ..As this mutation is also found in other myeloproliferative disorders, this unique mutation will permit a new molecular classification of these disorders and novel therapeutical approaches...
  7. ncbi Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
    W S Pear
    Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA
    Blood 92:3780-92. 1998
    ..bone marrow cells succumb to a myeloproliferative disease between 3 and 5 weeks after bone marrow transplantation. The myeloproliferative disease recapitulates many of the hallmarks of human CML and is characterized ..
  8. ncbi Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    Ryota Uemura
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Circ Res 98:1414-21. 2006
    ..Preconditioning of BMSCs enhanced their survival and ability to attenuate LV remodeling, which was attributable, in part, to paracrine effects...
  9. ncbi Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial
    Eriko Tateishi-Yuyama
    Department of Medicine II and Cardiovascular Centre, Kansai Medical University, Osaka, Japan
    Lancet 360:427-35. 2002
    ..We investigated efficacy and safety of autologous implantation of bone marrow-mononuclear cells in patients with ischaemic limbs because of peripheral arterial disease...
  10. ncbi Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999
    ..From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability...
  11. ncbi Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    Bodo E Strauer
    Department of Medicine, Division of Cardiology, Heinrich Heine University of Dusseldorf, Germany
    Circulation 106:1913-8. 2002
    ..For this reason, we analyzed 10 patients who were treated by intracoronary transplantation of autologous, mononuclear bone marrow cells (BMCs) in addition to standard therapy after MI...
  12. ncbi Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
    Massimiliano Gnecchi
    Nat Med 11:367-8. 2005
  13. ncbi Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction
    Volker Schachinger
    Department of Internal Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1210-21. 2006
    ..Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction...
  14. ncbi Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    Nature 425:968-73. 2003
    ..Furthermore, bone marrow transplantation demonstrates that BMDCs fuse in vivo with hepatocytes in liver, Purkinje neurons in the brain and ..
  15. pmc Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
    Jeremy S Duffield
    Renal Division and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 115:1743-55. 2005
    ..It is likely that intrinsic tubular cell proliferation accounts for functionally significant replenishment of the tubular epithelium after ischemia...
  16. ncbi Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow
    E Mezey
    Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Science 290:1779-82. 2000
    ..These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury...
  17. ncbi Dystrophin expression in the mdx mouse restored by stem cell transplantation
    E Gussoni
    Division of Genetics, Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 401:390-4. 1999
    ..Here we report the results of bone marrow transplantation studies in the mdx mouse, an animal model of Duchenne's muscular dystrophy, which indicate that the ..
  18. ncbi Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial
    Kai C Wollert
    Department of Cardiology, Hanover Medical School, Hanover, Germany
    Lancet 364:141-8. 2004
    ..In this randomised trial, we aimed to assess whether intracoronary transfer of autologous bone-marrow cells could improve global left-ventricular ejection fraction (LVEF) at 6 months' follow-up...
  19. pmc Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice
    Edwin Kanters
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Invest 112:1176-85. 2003
    ..Our data show that inhibition of the NF-kappaB pathway in macrophages leads to more severe atherosclerosis in mice, possibly by affecting the pro- and anti-inflammatory balance that controls the development of atherosclerosis...
  20. ncbi Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovasculariz
    Ken ichi Hiasa
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Circulation 109:2454-61. 2004
    ..We therefore hypothesized that SDF-1alpha gene transfer would induce therapeutic neovascularization in vivo by functioning as a chemokine of EPC...
  21. ncbi Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction
    Hiroshi Kawada
    Division of Hematology, Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Blood 104:3581-7. 2004
    ..Together, these results suggest that the origin of the vast majority of BM-derived cardiomyocytes is MSCs...
  22. pmc Bone marrow-derived progenitor cells in pulmonary fibrosis
    Naozumi Hashimoto
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 113:243-52. 2004
    ..Thus the collagen-producing lung fibroblasts in pulmonary fibrosis can also be derived from BM progenitor cells...
  23. ncbi Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial
    Gerd P Meyer
    Department of Cardiology, Hannover Medical School, Hannover, Germany
    Circulation 113:1287-94. 2006
    ..The critical question of whether BMC transfer can have a sustained impact on LV function remains unanswered...
  24. pmc MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    L M Coussens
    Cancer Research Institute, University of California, San Francisco 94143, USA
    Cell 103:481-90. 2000
    ..Chimeric mice expressing MMP-9 only in cells of hematopoietic origin, produced by bone marrow transplantation, reconstitute the MMP-9-dependent contributions to squamous carcinogenesis...
  25. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  26. ncbi Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Yamaguchi, Japan
    Hepatology 40:1304-11. 2004
    ..This finding introduces a new concept for the therapy of liver fibrosis...
  27. ncbi Augmentation of postnatal neovascularization with autologous bone marrow transplantation
    S Shintani
    Cardiovascular Research Institute and the Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    Circulation 103:897-903. 2001
    ..CONCLUSIONS: Direct local transplantation of autologous BM-MNCs seems to be a useful strategy for therapeutic neovascularization in ischemic tissues in adults, consistent with "therapeutic vasculogenesis."..
  28. ncbi Aging, progenitor cell exhaustion, and atherosclerosis
    Frederick M Rauscher
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Box 3845, Durham, NC 27710, USA
    Circulation 108:457-63. 2003
    ..We hypothesize that the effect of time in atherosclerosis progression is related to obsolescence of endogenous progenitor cells that normally repair and rejuvenate the arteries...
  29. ncbi Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment
    J Priller
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Nat Med 7:1356-61. 2001
    ..Microglial engraftment is enhanced by neuropathology, and gene-modified myeloid cells are specifically attracted to the sites of neuronal damage. Thus, microglia may serve as vehicles for gene delivery to the nervous system...
  30. pmc Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    Petra Hoffmann
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    J Exp Med 196:389-99. 2002
    ..Our results demonstrate that the balance of donor-type CD4(+)CD25(+) T(reg) and conventional CD4(+)CD25(-) T cells can determine the outcome of aGVHD...
  31. ncbi Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury
    J Dawn Abbott
    Department of Cardiology, Yale University Medical School, New Haven, Conn, USA
    Circulation 110:3300-5. 2004
    ..The mechanisms determining BMDC recruitment to the heart remain unclear. We investigated the role of stromal cell-derived factor-1alpha (SDF-1) in this process...
  32. pmc IL-17 contributes to CD4-mediated graft-versus-host disease
    Lucy W Kappel
    Department of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 113:945-52. 2009
    ..We conclude that IL-17 is dispensable for GVHD and GVT activity by whole T cells, but contributes to the early development of CD4-mediated GVHD by promoting production of proinflammatory cytokines...
  33. ncbi Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta
    E M Horwitz
    Cell and Gene Therapy Program, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 97:1227-31. 2001
    ..The report describes clinical responses of the first children to undergo allogeneic bone marrow transplantation (BMT) for severe osteogenesis imperfecta (OI), a genetic disorder characterized by defective type I ..
  34. ncbi Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
    Hua Han
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Int Immunol 14:637-45. 2002
    ..Myeloid and B lineage differentiation appears normal in the bone marrow of RBP-J-inactivated mice. These results suggest that RBP-J, probably by mediating Notch signaling, controls T versus B cell fate decision in lymphoid progenitors...
  35. pmc A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation
    J Luis Espinoza
    Department of Hematology and Oncology, Kanazawa University Hospital, Kanazawa, Japan
    PLoS ONE 6:e26229. 2011
    ....
  36. pmc Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair
    Francesco S Loffredo
    Harvard Stem Cell Institute and the Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    Cell Stem Cell 8:389-98. 2011
    ..Therapy with c-kit(+) cells but not mesenchymal stem cells improved cardiac function. These findings suggest that stimulation of endogenous cardiogenic progenitor activity is a critical mechanism of cardiac cell therapy...
  37. ncbi FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
    Louise M Kelly
    Division of Hematology Oncology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Blood 99:310-8. 2002
    ..human leukemia samples and assayed for transformation of primary hematopoietic cells using a murine bone marrow transplantation assay...
  38. ncbi Stem cell therapy in a caprine model of osteoarthritis
    J Mary Murphy
    Osiris Therapeutics, Baltimore, Maryland 21231, USA
    Arthritis Rheum 48:3464-74. 2003
    ....
  39. ncbi Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice
    Nicoletta Eliopoulos
    Lady Davis Institute for Medical Research, McGill University, 3755 Cote St Catherine Rd, Montreal, QC Canada H3T1E2
    Blood 106:4057-65. 2005
    ..These results strongly suggest that MSCs are not intrinsically immunoprivileged and cannot serve as a "universal donor" in immunocompetent MHC-mismatched recipients...
  40. ncbi Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials
    Michael J Lipinski
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    J Am Coll Cardiol 50:1761-7. 2007
    ..We aimed to perform a meta-analysis of clinical trials on intracoronary cell therapy after acute myocardial infarction (AMI)...
  41. doi Bone marrow cells are a rich source of growth factors and cytokines: implications for cell therapy trials after myocardial infarction
    Mortimer Korf-Klingebiel
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 29:2851-8. 2008
    ..Release of paracrine factors has been proposed as a mechanism for these therapeutic effects; however, this hypothesis has not been tested in humans...
  42. ncbi Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells
    Dirk H Walter
    Department of Medicine Cardiovascular Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 105:3017-24. 2002
    ..Primary and secondary prevention trials suggest that statins possess favorable effects independent of cholesterol reduction. We investigated whether statin therapy may also accelerate reendothelialization after carotid balloon injury...
  43. ncbi Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice
    Natalie C Direkze
    Histopathology Unit, Cancer Research UK London Research Institute, London, United Kingdom
    Stem Cells 21:514-20. 2003
    ..005). Bone-marrow-derived fibroblasts were also found. We suggest that bone marrow contributes to a circulating population of cells and, in the context of injury, these cells are recruited and contribute to tissue repair...
  44. ncbi The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
    S J Morrison
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 1:661-73. 1994
    ..The ability to predict the longevity of reconstitution based on lineage marker expression indicates that reconstitution potential is deterministic, not stochastic...
  45. ncbi Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome
    D Lu
    Department of Neurosurgery, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Neuroreport 12:559-63. 2001
    ..MSCs were also found in other organs and primarily localized to the vascular structures, without any obvious adverse effects. Our data suggest that i.v. administration of MSCs may be useful in the treatment of TBI...
  46. pmc Transplanted bone marrow generates new neurons in human brains
    Eva Mezey
    National Institutes of Health NIH National Institute of Neurological Disorders and Stroke NINDS In situ Hybridization Facility ISHF, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:1364-9. 2003
    ..Perhaps this phenomenon could be exploited to prevent the development or progression of neurodegenerative diseases or to repair tissue damaged by infarction or trauma...
  47. ncbi Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome
    Neal Flomenberg
    Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 104:1923-30. 2004
    ..When clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome...
  48. ncbi BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury
    P Lu
    Department of Neurosciences and Center for Neural Repair, University of California at San Diego, La Jolla, CA 92093 0626, USA
    Exp Neurol 191:344-60. 2005
    ..Combination therapy with other experimental approaches will likely be required to achieve axonal growth beyond the lesion site and functional recovery...
  49. pmc Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney
    Fangming Lin
    Department of Pediatrics and Department of Internal Medicine and Division of Basic Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 5390 9063, USA
    J Clin Invest 115:1756-64. 2005
    ..These results show that intrarenal cells are the main source of renal repair, and a single injection of BMCs does not make a significant contribution to renal functional or structural recovery...
  50. ncbi Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions
    T N Small
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 93:467-80. 1999
    Unrelated bone marrow transplantation (BMT) is often complicated by fatal opportunistic infections...
  51. ncbi Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease
    Yidan D Zhao
    Terrence Donnelly Vascular Biology Laboratories, St Michael s Hospital and the McLaughlin Center for Molecular Medicine, University of Toronto, Canada
    Circ Res 96:442-50. 2005
    ..Therefore, the regeneration of lung vascular endothelium by injection of progenitor cells may represent a novel treatment paradigm for patients with PAH...
  52. pmc Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation
    Emanuela M Bruscia
    Department of Laboratory Medicine, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:2965-70. 2006
    ..Detection of CFTR mRNA and protein in tissues of transplanted CFTR-/- mice supports these data...
  53. doi Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia
    Satoaki Matoba
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am Heart J 156:1010-8. 2008
    ....
  54. pmc A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation
    Leah L N Hubbard
    Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 184:6299-308. 2010
    ..In a mouse model of syngeneic bone marrow transplantation (BMT), we previously reported that PGE(2) is overproduced in lungs of BMT mice, significantly impairing ..
  55. ncbi Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells
    Martin Korbling
    Departments of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 346:738-46. 2002
    ..Bone marrow contains stem cells with the potential to differentiate into mature cells of various organs. We determined whether circulating stem cells have a similar potential...
  56. pmc Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice
    Masato Furuhashi
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 118:2640-50. 2008
    ..Using radiation chimerism through bone marrow transplantation, we generated mice with FABP deficiency in bone marrow and stroma-derived elements in vivo and studied ..
  57. ncbi Marrow stromal cells as stem cells for nonhematopoietic tissues
    D J Prockop
    Center for Gene Therapy, Allegheny University of the Health Sciences, MCP Hahnemann School of Medicine, 245 North 15 Street, Mail Stop 421, Philadelphia, PA 19102, USA
    Science 276:71-4. 1997
    ..Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy...
  58. ncbi Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease
    O Alpdogan
    Department of Medicine and Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Blood 98:2256-65. 2001
    Prolonged immunodeficiency after allogeneic bone marrow transplantation (BMT) causes significant morbidity and mortality from infection...
  59. pmc Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
    Graciela Andonegui
    Immunology Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 111:1011-20. 2003
    ..In conclusion, our data challenge the view that LPS directly activates neutrophils to trap in lungs and suggest a far more important role than previously appreciated for the endothelial cells...
  60. ncbi Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice
    Emanuela M Bruscia
    Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, Connecticut 06520 8035, USA
    Stem Cells 24:2299-308. 2006
    ..Here we tested whether the degree of bone marrow to epithelial engraftment would be higher if bone marrow transplantation (BMT) were performed on 1-day-old mice, when tissues are undergoing rapid growth and remodeling...
  61. ncbi Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract
    Ryuichi Okamoto
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    Nat Med 8:1011-7. 2002
    ....
  62. ncbi Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial
    Volker Schachinger
    Department of Cardiology, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    J Am Coll Cardiol 44:1690-9. 2004
    ....
  63. pmc Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F
    Virginia M Zaleskas
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 1:e18. 2006
    ..However, the role of mutant JAK2 in disease pathogenesis is unclear...
  64. doi Intravenous autologous bone marrow mononuclear cells for ischemic stroke
    Sean I Savitz
    Department of Neurology, University of Texas Medical School at Houston, Houston, TX, USA
    Ann Neurol 70:59-69. 2011
    ..Mononuclear cells (MNCs) from the bone marrow reduce neurological deficits in animal stroke models. We determined if autologous MNC infusion was feasible and safe in patients with ischemic stroke...
  65. ncbi Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia
    S Fuchs
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    J Am Coll Cardiol 37:1726-32. 2001
    ..We also defined, in vitro, whether bone marrow (BM) cells secrete vascular endothelial growth factor (VEGF) and macrophage chemoattractant protein-1 (MCP-1)...
  66. ncbi Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study
    R E Curtis
    Division of Cancer Epidemiology, Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA
    Blood 94:2208-16. 1999
    We evaluated 18,014 patients who underwent allogeneic bone marrow transplantation (BMT) at 235 centers worldwide to examine the incidence of and risk factors for posttransplant lymphoproliferative disorders (PTLD)...
  67. pmc Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation
    R Wada
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:10954-9. 2000
    ..Extensive microglia activation also was detected in a human case of Sandhoff disease. Bone marrow transplantation of Sandhoff disease mice suppressed both the explosive expansion of activated microglia and the ..
  68. pmc Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats
    Miranda Brenneman
    Department ofNeurology, University of Texas, Houston Medical School, Houston, Texas 77030, USA
    J Cereb Blood Flow Metab 30:140-9. 2010
    ..Autologous bone marrow MNCs can be safely harvested from rodents after stroke, migrate to the peri-infarct area, enhance recovery, and modulate the post-ischemic inflammatory response...
  69. ncbi Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia
    V Rocha
    Eurocord-Cord Blood Transplant Group (CBTG) and Biostatistics Department, Saint Louis Hospital AP-HP, University of Paris 7, France
    Blood 97:2962-71. 2001
    ..39; 95CI: 0.97-1.99; P <.07). In conclusion, the use of UCBT, as a source of hematopoietic stem cells, is a reasonable option for children with AL lacking an acceptably matched unrelated marrow donor...
  70. pmc Mobilized bone marrow cells repair the infarcted heart, improving function and survival
    D Orlic
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 98:10344-9. 2001
    ..In conclusion, mobilization of primitive BMC by cytokines might offer a noninvasive therapeutic strategy for the regeneration of the myocardium lost as a result of ischemic heart disease and, perhaps, other forms of cardiac pathology...
  71. ncbi Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation
    J Storek
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA
    Blood 97:3380-9. 2001
    ..008). In conclusion, blood stem cell recipients have higher lymphocyte-subset counts and this appears to result in fewer infections. (Blood. 2001;97:3380-3389)..
  72. ncbi Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
    Dullei Min
    Division of Research Immunology BMT, Childrens Hospital Los Angeles, CA 90027, USA
    Blood 99:4592-600. 2002
    ..thymopoietic capacity contributes to the severe and clinically significant immune deficiency seen after bone marrow transplantation (BMT)...
  73. ncbi Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice
    Sergio Fazio
    Vanderbilt University Medical Center, Departments of Medicine, Nashville, TN 37232, USA
    J Lipid Res 43:1602-9. 2002
    ..of macrophage apoE into mice lacking both apoE and the LDL receptor (apoE(-)(/-)/LDLR(-)(/-)) through bone marrow transplantation (apoE(+)(/+)/LDLR(-)(/-)-->apoE(-)(/-)/LDLR(-)(/-)) produces progressive accumulation of apoE in ..
  74. ncbi Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells. A pilot study
    Valérie Gangji
    Department of Rheumatology and Physical Medicine, Erasme University Hospital, Brussels, Belgium
    J Bone Joint Surg Am 86:1153-60. 2004
    ..For this reason, we studied the implantation of autologous bone-marrow mononuclear cells in a necrotic lesion of the femoral head to determine the effect on the clinical symptoms and the stage and volume of osteonecrosis...
  75. ncbi Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction
    Ketil Lunde
    Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    N Engl J Med 355:1199-209. 2006
    ..We designed a randomized, controlled trial to further investigate the effects of this treatment...
  76. ncbi Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation
    Erica L Herzog
    Yale University School of Medicine, Internal Medicine Pulmonary and Critical Care Division, 333 Cedar St, TAC 441 S, New Haven CT 06511, USA
    FASEB J 21:2592-601. 2007
    ..This process does not reverse inflammation caused by Sp-C deficiency; nevertheless, further investigation may identify phenotypes benefiting from such an approach...
  77. ncbi Contribution of bone marrow-derived stem cells to endometrium and endometriosis
    Hongling DU
    Division of Reproductive Endocrinology, Department of Medicine, Cellular and Developmental Biology, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Stem Cells 25:2082-6. 2007
    ..We investigate whether BMDCs can localize to uterine endometrium and to endometriosis. After bone marrow transplantation, male donor-derived bone marrow cells were found in the uterine endometrium of female mice...
  78. pmc Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells
    Cindy G Leung
    Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 204:1603-11. 2007
    ..Our studies demonstrate that survivin is essential for steady-state hematopoiesis and survival of the adult, and further, that a high level of survivin expression is critical for proper erythroid differentiation...
  79. pmc Radiation damage increases Purkinje neuron heterokaryons in neonatal cerebellum
    Silvia Espejel
    Department of Neurological Surgery, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA
    Ann Neurol 66:100-9. 2009
    ..Here we investigated whether radiation plays a role in the formation of Purkinje neuron heterokaryons...
  80. doi Bone marrow transplantation in mice as a tool for studying the role of hematopoietic cells in metabolic and cardiovascular diseases
    Marcela Aparicio-Vergara
    Molecular Genetics, Medical Biology Section, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Atherosclerosis 213:335-44. 2010
    ..Here, we will describe the potential of the bone marrow transplantation approach and discuss recent developments, including the use of virally transduced cells...
  81. doi The prevention of induced oral mucositis with low-level laser therapy in bone marrow transplantation patients: a randomized clinical trial
    Geisa Badauy Lauria Silva
    Hematopoietic Stem Cell Transplant Unit, Araujo Jorge Hospital, Goiás Fight Cancer Association, Goiania, Goias, Brazil
    Photomed Laser Surg 29:27-31. 2011
    ..The aim of this study was to investigate the clinical effects of low-level laser therapy (LLLT) on the prevention of conditioning-induced OM in hematopoietic stem cell transplantation (HSCT)...
  82. pmc Transplantation of hematopoietic stem cells in human severe combined immunodeficiency: longterm outcomes
    Rebecca H Buckley
    Departments of Pediatrics and Immunology, Duke University Medical Center, Box 2898 or 363 Jones Building, Durham, NC 27710, USA
    Immunol Res 49:25-43. 2011
    ..marrow transplant was given in 1968, the standard treatment for all forms of SCID has been allogeneic bone marrow transplantation. Both HLA-identical unfractionated and T-cell-depleted HLA-haploidentical bone marrow transplants have ..
  83. doi Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia: a comparison of atherosclerotic peripheral arterial disease and Buerger disease
    Naomi Idei
    Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Circ Cardiovasc Interv 4:15-25. 2011
    ..The purpose of this study was to evaluate long-term clinical outcomes after autologous BM-MNC implantation in patients with CLI...
  84. doi Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: a meta-analysis
    Peter Donndorf
    Department of Cardiac Surgery, University of Rostock, Rostock, Germany
    J Thorac Cardiovasc Surg 142:911-20. 2011
    ..We therefore conducted a systematic review and meta-analysis of available publications regarding the efficacy and safety of intramyocardial bone marrow stem cell transplantation during coronary artery bypass grafting...
  85. pmc Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation
    Isao Tawara
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 109:564-9. 2012
    ..disease (GvHD) is a major complication that prevents successful outcomes after allogeneic bone marrow transplantation (BMT), an effective therapy for hematological malignancies...
  86. doi Regulation of cardiac microRNAs by bone marrow mononuclear cell therapy in myocardial infarction
    Kazuma Iekushi
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt 60590, Germany
    Circulation 125:1765-73, S1-7. 2012
    ..MicroRNAs (miRNAs) are key regulators of gene expression and modulate the pathophysiology of cardiovascular diseases...
  87. doi Hematopoietic stem cell engraftment and seeding permits multi-lymphoid chimerism in vascularized bone marrow transplants
    M Siemionow
    Department of Plastic Surgery, The Cleveland Clinic, Cleveland, OH, USA
    Am J Transplant 8:1163-76. 2008
    Vascularized bone marrow transplantation (VBMT) across a MHC barrier under a 7-day alphabeta-TCR mAb and CsA protocol facilitated multiple hematolymphoid chimerism via trafficking of the immature (CD90) bone marrow cells (BMC) between ..
  88. pmc Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts
    Ping Yu
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1457, USA
    Immunology 127:500-11. 2009
    ..of donor C57BL/6 (H-2(b)) immature dendritic cells (imDCs) to tolerize the BALB/c (H-2(d)) recipient to bone marrow transplantation (BMT), allowing the induction of mixed chimerism without immunosuppression or myeloablation...
  89. doi Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study
    Andre Castro Lyra
    Hospital Sao Rafael and c HUPES Federal Univeristy of Bahia, Medicine Gastro Hepatology Service, Graz, Austria
    Eur J Gastroenterol Hepatol 22:33-42. 2010
    ..This randomized controlled study evaluated the effect of autologous infusion of bone marrow cells (BMC) in patients with hepatic cirrhosis...
  90. pmc Successful modulation of type 2 diabetes in db/db mice with intra-bone marrow--bone marrow transplantation plus concurrent thymic transplantation
    Ming Li
    Department of Stem Cell Disorders, Kansai Medical University, Moriguchi City, Osaka 570 8506, Japan
    J Autoimmun 35:414-23. 2010
    ..Therefore, we hypothesized that intra-bone marrow-bone marrow transplantation plus thymus transplantation (IBM-BMT + TT) could be used to treat T2 DM by normalizing the T cell ..
  91. pmc Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis
    Saskia C A de Jager
    Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, Netherlands
    J Exp Med 208:217-25. 2011
    ..Our study is the first to identify GDF-15 as an acute phase modifier of CCR2/TGFβRII-dependent inflammatory responses to vascular injury...
  92. doi Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: Five year follow-up of a prospective controlled study
    Valérie Gangji
    Department of Rheumatology and Physical Medicine, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Bone 49:1005-9. 2011
    ..To determine the efficacy of bone marrow cell implantation into the necrotic lesion of the femoral head on clinical symptoms and the progression of osteonecrosis of the femoral head in comparison with core decompression...
  93. ncbi Liver from bone marrow in humans
    N D Theise
    Department of Pathology, New York University, School of Medicine, New York, NY 10016, USA
    Hepatology 32:11-6. 2000
    ....
  94. ncbi Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation
    Jan Inge Henter
    Childhood Cancer Research Unit, Karolinska Institutet, Department of Pediatric Hematology and Oncology, Karolinska Hospital, Stockholm, Sweden
    Blood 100:2367-73. 2002
    ..corticosteroids, cyclosporin A, and, in selected patients, intrathecal methotrexate), followed by bone marrow transplantation (BMT) in persistent, recurring, and/or familial disease...
  95. ncbi Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury
    Eva Sykova
    Center for Cell Therapy and Tissue Repair, Charles University, Prague, Czech Republic
    Cell Transplant 15:675-87. 2006
    ..Trials involving a larger population of patients and different cell types are needed before further conclusions can be drawn...
  96. pmc Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study
    Smita Bhatia
    Population Sciences, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
    Blood 110:3784-92. 2007
    ..This study demonstrates that mortality rates remain twice as high as that of the general population among 15-year survivors of HCT, and that the survivors face challenges affecting their health and well-being...
  97. ncbi Haeme oxygenase promotes progenitor cell mobilization, neovascularization, and functional recovery after critical hindlimb ischaemia in mice
    Jörn Tongers
    Department of Cardiology and Angiology, Hannover University Medical School, 30625 Hannover, Germany
    Cardiovasc Res 78:294-300. 2008
    ..We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI)...
  98. doi Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review
    Enca Martin-Rendon
    Stem Cell Research Laboratory, NHS Blood and Transplant, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, UK
    Eur Heart J 29:1807-18. 2008
    ..To provide systematic assessment of the safety and efficacy of autologous bone marrow-derived stem cell (BMSC) transplantation in acute myocardial infarction (AMI) based on clinical evidence...
  99. doi Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy
    Johanna A Miettinen
    University of Oulu, Department of Internal Medicine P O Box 5000 Kajaanintie 50, FIN 90014 University of Oulu, Oulu, Finland
    Heart 96:362-7. 2010
    ....
  100. doi Transplantation tolerance through mixed chimerism
    Nina Pilat
    Division of Transplantation, Department of Surgery, Vienna General Hospital, Medical University of Vienna, 1090 Vienna, Austria
    Nat Rev Nephrol 6:594-605. 2010
    ..in regular clinical practice has been hampered by the toxic side effects inherent to conventional bone marrow transplantation protocols...
  101. doi Plerixafor and Filgrastim XM02 (Tevagastrim) as a first line peripheral blood stem cell mobilisation strategy in patients with multiple myeloma and lymphoma candidated to autologous bone marrow transplantation
    Giovanna Andreola
    Stem Cell Collection Unit, European Institute of Oncology, Milan, Italy
    Eur J Haematol 88:154-8. 2012
    ..0 × 10(6) /kg in a median number of procedures of one. Although preliminary, these data show the combination of biosimilar filgrastim and plerixafor is effective and provides a non-toxic approach to mobilise stem cells...

Research Grants84

  1. Sogol Mostoufi-Moab; Fiscal Year: 2016
    ....
  2. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..sclerosis;Type I Diabetes, and as anti-rejection agents following solid organ and bone marrow transplantation. Our preliminary studies suggest that these immune modifying agents may illicit a serious skeletal ..
  3. Patrick Cahan; Fiscal Year: 2016
    ..Indeed, HSCs are responsible for the repopulation of the hematopoietic compartment of bone marrow transplantation patients...
  4. KATHERINE YUDEH KING; Fiscal Year: 2014
    ..This research will have immediate application for patients recovering from bone marrow transplantation. Furthermore, this work will lead to insight and potential interventions for myelosuppression as a ..
  5. Development of a Pediatric Mylelodysplastic Syndrome Patient Registry
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..very little is known about the initiating events leading to pMDS, and thus no targeted therapies exist;bone marrow transplantation is the only therapeutic option for these patients...
  6. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..Although bone marrow transplantation shows potential, there is a controversy regarding the cell involved...
  7. Oliver W Press; Fiscal Year: 2014
    ..We therefore anticipate rapid translation of the optimized promising pretargeted RIT into our clinical RIT HCT program for AML and MDS. ..
  8. Macrophage-based Human Gene Therapy for Hereditary PAP
    Bruce C Trapnell; Fiscal Year: 2012
    ..b>Bone marrow transplantation (BMT) is a therapeutic option for these children with PAP and was attempted in one child who died of a ..
  9. CD4+ T cells in Invasive Aspergillosis
    Amariliz Rivera; Fiscal Year: 2012
    ..Cancer patients that receive treatment for hematologic malignancies or bone marrow transplantation are at increased risk for developing invasive aspergillosis (IA)...
  10. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..g., HO-1). We will investigate this aspect using bone marrow transplantation from sickle mice into mice partially deficient in HIF-1[unreadable], and by super induction of HIF-1[..
  11. Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
    Chandan Guha; Fiscal Year: 2010
    ..g., blood transfusion for hemorrhage or bone marrow transplantation for cytoablative damage...
  12. Novel therapies for Fanconi anemia
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..b>Bone marrow transplantation has cured some patients of their bone marrow failure or hematologic malignancies...
  13. Post-translational regulation of MLL in leukemogenesis
    ANDREW GEORGE MUNTEAN; Fiscal Year: 2012
    ..In vivo bone marrow transplantation assays in mouse models will be used to assess the efficacy of peptide or chemical compound mediated ..
  14. Cong Yan; Fiscal Year: 2015
    ..Adaptive bone marrow transplantation between wild type and lal-/- mice showed that both cell autonomous and tissue microenvironments ..
  15. ANDREW GEORGE MUNTEAN; Fiscal Year: 2014
    ..In vivo bone marrow transplantation assays in mouse models will be used to assess the efficacy of peptide or chemical compound mediated ..
  16. Research Career Development in Child Health
    Michael W Konstan; Fiscal Year: 2012
    ..associated with prematurity, cystic fibrosis, asthma, pneumonia, sepsis, cancer, coagulation disorders, bone marrow transplantation, diabetes, obesity and cardiovascular disease, diseases caused by viral and bacterial pathogens, and ..
  17. Prevention of acute GvHD by inhibition of cdk2
    Vassiliki A Boussiotis; Fiscal Year: 2012
    ..T cells in vitro and in vivo and protected from acute lethal GvHD in a mouse model of allogeneic bone marrow transplantation. Our studies revealed that inhibition of cdk2 prevented expansion of alloreactive T cells while sparing ..
  18. ERNESTO ROQUE BONGARZONE; Fiscal Year: 2016
    ..targeting specific aspects of neurodegeneration in Krabbe disease can be combined with traditional bone marrow transplantation to fully prevent development of the disease...
  19. MOHAMED AL SAYED AL-SHABRAWEY; Fiscal Year: 2016
    ..versus the circulating leukocyte 12/15-LOX in diabetes-induced retinal inflammation we will utilize bone marrow transplantation (BMT) studies to determine the effect of wild type leukocytes with 12/15-LOX knockout retinal ..
  20. ROCK inhibitor suppression of GVHD with retention of GVL response
    Sujatha Iyengar; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bone marrow transplantation (BMT) following ablation of the patient's hematapoietic system is a life-saving treatment for several types of leukemia. Acute graft vs...
  21. Functional analysis of mDia formins in hematopoietic stem cell engraftment and mi
    Peng Ji; Fiscal Year: 2010
    ..HSC engraftment and migration are critical for successful bone marrow transplantation, which has become a routine clinical strategy for treating patients with many blood related diseases ..
  22. Anja Jaeschke; Fiscal Year: 2014
    ..In Aim 3 reciprocal bone marrow transplantation studies will be used to examine the tissue specific role of MLK3 in the development of insulin ..
  23. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2013
    ..of the immunologic consequences of mTOR inhibition will result in safer and more successful bone marrow transplantation, allowing expansion of this potentially curative therapy to a wider number of patients with chronic ..
  24. Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory Response
    Gary S Gilkeson; Fiscal Year: 2013
    ..deficiency on known mechanisms of lupus pathogenesis using sle1, sle3 and sle1/3 congenic mice and bone marrow transplantation of ER[unreadable] KO and ER[unreadable] WT mice. 2...
  25. Peripheral T Cell tolerance by targeting AKT
    Claudio Anasetti; Fiscal Year: 2010
    ..The objective of this proposal is to control acute GVHD in pre- clinical models of allogeneic bone marrow transplantation (BMT) by targeting the AKT pathway...
  26. The AMP-activated protein kinase (AMPK) antagonizes inflammation through SIRT1
    Hang Shi; Fiscal Year: 2012
    ..We will perform bone marrow transplantation to generate mice with alpha1AMPK-deficient macrophages, and will characterize the inflammatory status ..
  27. Mitchell W Mutz; Fiscal Year: 2014
    ..of calcineurin inhibition has been one of the greatest contributions to our current solid organ and bone marrow transplantation abilities. However, inhibition of HC causes severe immunosuppression and toxicity...
  28. Bruce R Blazar; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Allogeneic bone marrow transplantation (BMT) can cure patients with risk acute myeloid leukemia (AML). Post-BMT recipients are highly susceptible to T cell responsive viral and fungal infections...
  29. Adipose Stem Cell Therapy for Krabbe Disease
    Bruce Bunnell; Fiscal Year: 2009
    ..The only available therapy is heterologous bone marrow transplantation during the earliest months of life to produce the active form of GALC through out the body...
  30. Tousled kinase contributes to survival of salivary acinar cells against radiation
    Gulshan Sunavala-Dossabhoy; Fiscal Year: 2013
    ..radiotherapy for head and neck cancers, early stage lymphomas, and full-body radiation before bone marrow transplantation. The most common and distressing oral symptom of radiotherapy is reduced saliva...
  31. Role of the zinc finger transcription factor ZBP89 in blood &vascular developmen
    M Amin Arnaout; Fiscal Year: 2013
    ..Aim 3). Genetic, biochemical, proteomics, genomics, stem cell cultures and bone marrow transplantation in mouse and zebrafish will be utilized...
  32. Benjamin Ping Chi Chen; Fiscal Year: 2016
    ..Although these mice die prematurely, they can be rescued with bone marrow transplantation. BMT-rescued DNA- PKcs3A/3A mice are prone to develop both hematologic and non-hematologic cancers...
  33. Regulation of Tumor Associated Macrophages by TGF-beta
    Venkateshwar G Keshamouni; Fiscal Year: 2012
    ..whether the primary effector cell critical for tumor growth inhibition in IRAK-M-/- mice is of myeloid origin, by bone marrow transplantation 4) determine the mechanism of TGF-[unreadable]-induced IRAK-M expression in macrophages.
  34. Kira Gritsman; Fiscal Year: 2014
    ..The mainstay of treatment is multi-agent chemotherapy and bone marrow transplantation, both of which have many complications and high mortality...
  35. Cell Based Therapies for Cystic Fibrosis
    Tracey L Bonfield; Fiscal Year: 2012
    ..The studies outlined in this proposal are aimed at evaluating whether bone marrow transplantation or adult human derived mesenchymal stem cells therapy has a beneficial effect on inflammatory outcomes ..
  36. Design of CNS-Permeable Agents for the Treatment of Lipid Storage Diseases
    Scott D Larsen; Fiscal Year: 2010
    ..Other forms of enzyme replacement, including gene therapy and bone marrow transplantation have been disappointing to date...
  37. Novel Compounds to Inactivate Oncogenic Fusion Proteins
    Jeffrey A Toretsky; Fiscal Year: 2013
    ..response rates have persisted for the past decade, even after dose-intensifying chemotherapy and bone marrow transplantation. Therefore, we need to discover novel therapeutic approaches to both reduce treatment related morbidity ..
  38. Parinda Mehta; Fiscal Year: 2015
    ..e. androgens or bone marrow transplantation, are associated with significant morbidity and mortality...
  39. Pathophysiology and potential therapy for a childhood neurodegenerative disease
    Marquis T Walker; Fiscal Year: 2011
    ..In addition, I propose to test whether bone marrow transplantation will reduce the severity of the phenotype...
  40. Abdominal Adipose Tissue Inflammation
    Peter S Tobias; Fiscal Year: 2013
    ..This idea will be tested by performing bone marrow transplantation of LDLr-/- mice with bone marrow donors from LDLr-/-TLR2-/- double mutant mice and LDLr-/- control mice...
  41. Masuko Ushio-Fukai; Fiscal Year: 2016
    ..b>Bone marrow transplantation, in vivo intravital microscopy and bioluminescence imaging, highly innovative Cu imaging analysis in ..
  42. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2011
    ..the bone marrow in normal conditions and in conditions of stress, such as inflammation, infections or bone marrow transplantation. In particular, we are focused on understanding the role of the Notch receptors in the maintenance and ..
  43. Jonathan Kipnis; Fiscal Year: 2016
    ..Our data implicate microglia as major players in Rett pathophysiology, and suggest that bone marrow transplantation might offer a feasible therapeutic approach for this devastating disorder...
  44. Adiponectin Actions on the Monocyte to Reduce Atherosclerosis
    Rajendra K Tangirala; Fiscal Year: 2013
    ..and the role of macrophage adiponectin receptors in vascular inflammation and atherosclerosis using bone marrow transplantation with AdipoR1/R2 knockout mice...
  45. CELLULAR MECHANISMS OF PTLD IN TRANSPLANT RECIPIENTS
    Olivia M Martinez; Fiscal Year: 2012
    ..disease (PTLD) describes a morphologically heterogeneous complication of solid organ and bone marrow transplantation that ranges from benign B cell hyperplasia to malignant lymphoma...
  46. Macrophage Mitochondrial Stress in Inflammation, Insulin Resistance &Obesity
    LIZA MAKOWSKI HAYES; Fiscal Year: 2012
    ..overall objective of this application in MP cell lines, primary MPs, and in obese mouse models after bone marrow transplantation to determine the contribution of MP-specific gene expression in adipose tissue in these aims...
  47. Immunosuppression by Adult Stem Cells
    Yufang Shi; Fiscal Year: 2013
    ..disorders, allergic reactions, rejection of transplants and graft-versus-host disease associated with bone marrow transplantation. It is likely that the very first clinical application of stem cell research will be the use of ..
  48. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey F Lodish; Fiscal Year: 2010
    ..Our studies can lead to major improvements in the clinical use of HSCs in bone marrow transplantation for treatment of leukemia and other cancers;many applications, especially transplantation using cord ..
  49. Peng Ji; Fiscal Year: 2014
    ..HSC engraftment and migration are critical for successful bone marrow transplantation, which has become a routine clinical strategy for treating patients with many blood related diseases ..
  50. Genome-wide Identification of Minor Histocompatibility Antigens
    Shoudan Liang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Allogeneic bone marrow transplantation (BMT) conveys a potent graft-versus-leukemia effect (GVL) that contributes to long-term remission for patients with leukemia...
  51. Syndecan-1 in Aortic Aneurysm Formation
    Elliot Chaikof; Fiscal Year: 2012
    ..formation and rupture, the incidence of these events will be studied using relevant transgenic mice and bone marrow transplantation protocols...
  52. JOHN PATRICK SHEEHAN; Fiscal Year: 2016
    ..basic and clinical aspects of hemostasis/inflammation, hematologic malignancies, and human stem cells/bone marrow transplantation. The faculty have broad expertise in both basic science and clinical sciences, including experimental ..
  53. Functional study of novel transcriptional regulators of hematopoietic stem cells
    Shannon L McKinney-Freeman; Fiscal Year: 2012
    ..of these cells to replenish hematopoiesis is exploited routinely to treat hematologic disease via bone marrow transplantation (BMT). However, many patients lack access to BMT because they lack suitable donors...
  54. Transfusion Induced BMT Rejection
    James C Zimring; Fiscal Year: 2013
    When successful, bone marrow transplantation (BMT) is a cure for non-malignant hematological disorders, including: sickle cell disease, aplastic anemia, thalassemia major, Diamond-Blackfan Anemia and Fanconi Anemia...
  55. Kentson Lam; Fiscal Year: 2014
    ..Overall, the insights revealed in this study will provide a better understanding of hematopoiesis, leading to improved treatments for blood-related disorders and better methods for bone marrow transplantation.
  56. EMBRYONIC STEM CELLS INDUCE SPECIFIC GRAFT TOLERANCE
    Nicholas Zavazava; Fiscal Year: 2012
    ..established approach to achieving tolerance is by establishing hematopoietic mixed chimerism through bone marrow transplantation of the donor into the recipient...
  57. Makiko Yasuda; Fiscal Year: 2014
    ..of hydroxymethylbilane synthase (HMB-synthase)], and 2) to evaluate the effectiveness of hepatocyte and bone marrow transplantation for AIP as proof-of-concept for future induced pluripotent stem (iPS) cell-based therapies for patients ..
  58. Mechanism of Apoptosis and Inhibition of Tumor Progression and Metastasis by Par-
    Vivek M Rangnekar; Fiscal Year: 2012
    ....
  59. Li Ru Zhao; Fiscal Year: 2014
    ..C57 BL mice expressing yellow or cyan fluorescent proteins only in neurons (Thy-1-YFP, Thy-1-CFP), and bone marrow transplantation to track BMSCs, this hypothesis will be tested by pursuing two specific aims...
  60. Alveolar Cell Dysfunction and Pulmonary Fibrosis
    Lisa R Young; Fiscal Year: 2011
    ..aims will employ genetic and cellular replacement, with type II cell-specific transgenesis and murine bone marrow transplantation, to define the contributions of alveolar macrophages and alveolar type II cells to the pulmonary ..
  61. David Kuhrt; Fiscal Year: 2015
    ..erythropoiesis in vivo during the anemia of 5-fluorouracil administration, sublethal irradiation or bone marrow transplantation. SPECIFIC AIM 2 will investigate Trib'3 molecular action mechanisms, including regulation of Erk1,..
  62. Myeloid-derived Suppressor Cells in Autoimmune Arthritis
    Katalin Mikecz; Fiscal Year: 2012
    ..indicate that many RA patients with severe treatment-refractory disease respond well to autologous bone marrow transplantation (ABMT)...
  63. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ..abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
  64. Stem Cell Transplantation for Hemoglobinopathies in Dogs
    JOHN HEARST; Fiscal Year: 2003
    b>Bone marrow transplantation has the potential of providing a complete cure of the disease symptoms of hemoglobinopathies...
  65. A QTL for fetal hemoglobin and F cells on chromosome 8q
    Swee Thein; Fiscal Year: 2003
    ..the use of drugs to remove iron and to control pain, and in cases with HLA-compatible siblings, bone marrow transplantation. Our studies and others, have shown that in both disorders, high levels of fetal hemoglobin (Hb F, ..
  66. Cord Blood Stem Cell Transplantation, Hemoglobinopathies
    JOHN HEARST; Fiscal Year: 2003
    b>Bone marrow transplantation has the potential of providing a complete cure of the disease symptoms of hemoglobinopathies...
  67. BONE MARROW TRANSPLANTATION FOR MUCOPOLYSACCHARIDOSIS
    Chester Whitley; Fiscal Year: 1993
    Pilot clinical trials of bone marrow transplantation (BMT) for lysosomal storage diseases have demonstrated that (1) this potential therapeutic modality is an effective means of introducing large amounts of enzyme-producing cells on a ..
  68. Donor CD8+ cell facilitates mixed chimerism in NOD mice
    Defu Zeng; Fiscal Year: 2005
    ..Induction of mixed chimerism via allogeneic bone marrow transplantation currently represents a successful regimen for induction of immune tolerance in laboratory animals such ..
  69. TUBA FEHR; Fiscal Year: 2015
    ..Psychosine accumulation leads a rapid loss of myelin and neuronal dysfunction. Although bone marrow transplantation (BMT) in KD children has resulted in significantly extended life spans, it has been limited in ..
  70. GASTRIC CANCER INDUCED BY H PYLORI IN P27 DEFICIENT MICE
    Steven Moss; Fiscal Year: 2009
    ..These hypotheses will be tested by 2 specific aims: 1. p27-/- mice will receive a bone marrow transplantation from ROSA 26 wild type mice (and vice-versa) prior to H...
  71. Genetic mechanisms which control hematopoietic cell migration
    GEOFFREY KANSAS; Fiscal Year: 2009
    ..stem cells (HSC) to appropriate microenvironments within the bone marrow is critical to the success of bone marrow transplantation (BMT)...
  72. BONE MARROW TRANSPLANTATION IN OIM--A GENE THERAPY MODEL
    DANIEL MC BRIDE; Fiscal Year: 2001
    ..by this proposal: (1) the identification and characterization of the cellular target vehicle using bone marrow transplantation and (2) determining the minimal level of replacement gene expression in transgenic mice that results in ..
  73. Preparative irradiation for hepatocyte transplantation
    Chandan Guha; Fiscal Year: 2009
    ..Although preparative irradiation has been used routinely for bone marrow transplantation, we were the first to apply it to facilitate HT...
  74. Genetic Manipulation of T Cells--PreClinical Models
    John Dipersio; Fiscal Year: 2005
    DESCRIPTION (Applicant's Description Verbatim): Allogeneic bone marrow transplantation is a curative therapy for hematologic malignancies, marrow failure states, and selected inherited metabolic diseases...
  75. Family Decision Making in Pediatric Bone Marrow Transplant
    Rebecca Pentz; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Allogeneic bone marrow transplantation (BMT) with a healthy sibling donor is a potentially curative, though life-threatening, treatment for certain high risk pediatric diseases...
  76. A Novel Antibody Therapeutic for Multiple Myeloma
    Koteswara Chintalacharuvu; Fiscal Year: 2009
    ..S.A. per year. Conventional therapies and/or bone marrow transplantation only improve survival time with a median of 30-36 months. The goal of Chimeric Technologies, Inc...
  77. ENDOTHELIUM REGULATION OF STEM CELL HOMING/PROLIFERATION
    Shahin Rafii; Fiscal Year: 2000
    Engraftment of hematopoietic stem or progenitor cells during bone marrow transplantation is dependent on the preferential homing of progenitors to the bone marrow microenvironment...
  78. MARROW TRANSPLANT THERAPY FOR MUCOPOLYSACCHARIDOSIS
    MARY THRALL; Fiscal Year: 1992
    b>Bone marrow transplantation is a promising therapy for some lysosomal storage disorders in human beings. Donor leukocytes may establish enzyme activity on a continual basis in amounts sufficient to be within normal limits...
  79. PROTEINASE 3 SPECIFIC IMMUNOTHERAPY OF LEUKEMIA
    Jeffrey Molldrem; Fiscal Year: 2002
    ..A significant graft versus leukemia (GVL) immune response, mediated by donor lymphocytes after allogeneic bone marrow transplantation (BMT), contributes to the cure of 40-50 percent of adult patients with myeloid leukemias...