heterotopic transplantation

Summary

Summary: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.

Top Publications

  1. ncbi Development of human fetal pancreas after transplantation into SCID mice
    Z Si
    Pancreas Transplant Unit, Prince of Wales Hospital, Sydney, NSW, Australia
    Cells Tissues Organs 168:147-57. 2001
  2. ncbi Heterotopic transplantation of the failing rat heart as a model of left ventricular mechanical unloading toward recovery
    Hiroshi Tsuneyoshi
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    ASAIO J 51:116-20. 2005
  3. ncbi Melatonin promotes the cumulus-oocyte complexes quality of vitrified-thawed murine ovaries; with increased mean number of follicles survival and ovary size following heterotopic transplantation
    Masoud Hemadi
    Department of Anatomy, Faculty of Medicine, Medical Sciences University of Tehran, Tehran, Iran
    Eur J Pharmacol 618:84-90. 2009
  4. ncbi Effect of site of transplantation on follicular development of human ovarian tissue transplanted into intact or castrated immunodeficient mice
    Hugo Hernandez-Fonseca
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Fertil Steril 81:888-92. 2004
  5. ncbi Heterotopic ovarian transplantation without vascular pedicle in syngeneic Lewis rats: long-term evaluation of effects on ovarian structure and function
    Justo Callejo
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hospital Universitari Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    Fertil Steril 77:396-402. 2002
  6. ncbi A new mouse model for intraportal islet transplantation with limited hepatic lobe as a graft site
    Yukihide Yonekawa
    Department of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 82:712-5. 2006
  7. ncbi Graft site and gonadotrophin stimulation influences the number and quality of oocytes from murine ovarian tissue grafts
    Hsiao Yun Yang
    Department of Physiology, Monash Medical Centre, Clayton, Australia 3168
    Reproduction 131:851-9. 2006
  8. ncbi Follicular growth in fresh and cryopreserved human ovarian cortical grafts transplanted to immunodeficient mice
    R Van den Broecke
    Department of Gynaecologic Oncology, Infertility Centre, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Eur J Obstet Gynecol Reprod Biol 97:193-201. 2001
  9. ncbi Embryo development after heterotopic transplantation of cryopreserved ovarian tissue
    Kutluk Oktay
    Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY 10021, USA
    Lancet 363:837-40. 2004
  10. ncbi Implantation site-dependent dysfunction of transplanted pancreatic islets
    Joey Lau
    Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Diabetes 56:1544-50. 2007

Research Grants

  1. PTLD: cytokine production and gene polymorphisms
    Robert Baiocchi; Fiscal Year: 2005
  2. Mentoring and Research in Mouse Models of Cancer and Infertility
    Diego H Castrillon; Fiscal Year: 2011
  3. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2004
  4. Human Keratin (K14)-MBP/MBP-TCR Transgenic Animal Model
    Kouichi Ito; Fiscal Year: 2009
  5. Glucose Regulated Gene Expression in the Heart
    Martin Young; Fiscal Year: 2002
  6. Characterization of Ocular Neural Stem Cells
    Iqbal Ahmad; Fiscal Year: 2004
  7. Role of integrins and activin in granulosa cell growth
    Kutluk Oktay; Fiscal Year: 2007
  8. Heart Xenotransplantation with Chimeric Donor Pigs
    William Beschorner; Fiscal Year: 2006
  9. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2009
  10. Vevo 770 High Resolution Ultrasound Imaging System
    Marielle Scherrer Crosbie; Fiscal Year: 2007

Detail Information

Publications206 found, 100 shown here

  1. ncbi Development of human fetal pancreas after transplantation into SCID mice
    Z Si
    Pancreas Transplant Unit, Prince of Wales Hospital, Sydney, NSW, Australia
    Cells Tissues Organs 168:147-57. 2001
    ..We hypothesize that following the transplantation of human fetal pancreatic tissue, exocrine cells mostly transdifferentiate into duct cells and these eventually develop into endocrine cells, in particular beta cells...
  2. ncbi Heterotopic transplantation of the failing rat heart as a model of left ventricular mechanical unloading toward recovery
    Hiroshi Tsuneyoshi
    Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    ASAIO J 51:116-20. 2005
    ..the functional recovery of the infarcted, failing rat heart in response to mechanical unloading after heterotopic transplantation. Heart failure was induced in Lewis rats by ligating the left anterior descending artery...
  3. ncbi Melatonin promotes the cumulus-oocyte complexes quality of vitrified-thawed murine ovaries; with increased mean number of follicles survival and ovary size following heterotopic transplantation
    Masoud Hemadi
    Department of Anatomy, Faculty of Medicine, Medical Sciences University of Tehran, Tehran, Iran
    Eur J Pharmacol 618:84-90. 2009
    ..the protective effect of melatonin on neonate murine ovarian tissue after vitrification, thawing and heterotopic transplantation into ovariectomized recipient mice...
  4. ncbi Effect of site of transplantation on follicular development of human ovarian tissue transplanted into intact or castrated immunodeficient mice
    Hugo Hernandez-Fonseca
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Fertil Steril 81:888-92. 2004
    ..To study the response of human ovarian xenografts to transplantation into different sites and in different host conditions...
  5. ncbi Heterotopic ovarian transplantation without vascular pedicle in syngeneic Lewis rats: long-term evaluation of effects on ovarian structure and function
    Justo Callejo
    Department of Obstetrics and Gynecology, Faculty of Medicine, Hospital Universitari Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
    Fertil Steril 77:396-402. 2002
    ..To assess the long-term efficacy of intraperitoneal (IP) and subcutaneous (SC) ovarian autotransplantation in rats...
  6. ncbi A new mouse model for intraportal islet transplantation with limited hepatic lobe as a graft site
    Yukihide Yonekawa
    Department of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Transplantation 82:712-5. 2006
    ..This model can be applied to investigate both the specific graft-recipient interaction in the liver and the islet graft contribution to the control of diabetes...
  7. ncbi Graft site and gonadotrophin stimulation influences the number and quality of oocytes from murine ovarian tissue grafts
    Hsiao Yun Yang
    Department of Physiology, Monash Medical Centre, Clayton, Australia 3168
    Reproduction 131:851-9. 2006
    ..In conclusion, graft site affects the number and quality of oocytes produced from ovarian grafts...
  8. ncbi Follicular growth in fresh and cryopreserved human ovarian cortical grafts transplanted to immunodeficient mice
    R Van den Broecke
    Department of Gynaecologic Oncology, Infertility Centre, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Eur J Obstet Gynecol Reprod Biol 97:193-201. 2001
    ..To investigate follicle growth in fresh and cryopreserved human ovarian cortical grafts transplanted to immunodeficient mice...
  9. ncbi Embryo development after heterotopic transplantation of cryopreserved ovarian tissue
    Kutluk Oktay
    Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY 10021, USA
    Lancet 363:837-40. 2004
    ..One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplantation of ovarian tissue...
  10. ncbi Implantation site-dependent dysfunction of transplanted pancreatic islets
    Joey Lau
    Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Diabetes 56:1544-50. 2007
    ..Clinical islet transplantations are performed through infusion of islets via the portal vein into the liver. This study aimed at characterizing the influence of the implantation microenvironment on islet graft metabolism and function...
  11. ncbi Development of antral follicles in human cryopreserved ovarian tissue following xenografting
    D A Gook
    Reproductive Biology Unit, Royal Women s Hospital, Australia
    Hum Reprod 16:417-22. 2001
    ..Pedicles containing germinal vesicle oocytes were observed protruding from the granulosa cell layers. The development and morphology of the cryopreserved and fresh tissue following grafting was similar...
  12. ncbi Offspring produced from heterotopic ovarian allografts in male and female recipient mice
    Tracey Waterhouse
    Department of Physiology, Monash University, Victoria 3800, Australia
    Reproduction 127:689-94. 2004
    ..In conclusion, this work has shown that the hormonal environment of male mice can support the growth of oocytes in ovarian allografts and that these oocytes can produce live offspring...
  13. ncbi Heterotopic autotransplantation of the ovary with microvascular anastomosis: a novel surgical technique
    Elisabeth Jeremias
    Department of Obstetrics and Gynecology, Minimally Invasive Surgery Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 77:1278-82. 2002
    ..To test the feasibility of transplanting an entire ovary with anastomosis of the ovarian vascular pedicle...
  14. ncbi Spontaneous conceptions and live birth after heterotopic ovarian transplantation: is there a germline stem cell connection?
    Kutluk Oktay
    Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hum Reprod 21:1345-8. 2006
    ....
  15. ncbi Blockade of complement inhibits obliterative bronchiolitis in rat tracheal allografts
    E A Kallio
    Cardiopulmonary Research Group of the Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Am J Respir Crit Care Med 161:1332-9. 2000
    ..A blockade of complement activation renders the chemokine milieu unattractive to neutrophils and also modulates the alloimmune response toward Th2 cytokines, which may have an antiproliferative role in fibroproliferative disorders...
  16. ncbi Functional studies of subcutaneous ovarian transplants in non-human primates: steroidogenesis, endometrial development, ovulation, menstrual patterns and gamete morphology
    John Schnorr
    Department of Obstetrics and Gynecology, The Howard and Georgeanna Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Hum Reprod 17:612-9. 2002
    ....
  17. ncbi Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin's disease
    Isabelle Demeestere
    Research Laboratory on Human Reproduction, Campus Erasme Bat GE CP636, 808 Route de Lennik, 1070, Brussels, Belgium
    Oncologist 12:1437-42. 2007
    ..Here, we describe the second published full-term spontaneous pregnancy after an orthotopic and heterotopic transplantation of cryopreserved ovarian tissue in a 31-year-old woman previously treated by conditioning therapy for ..
  18. ncbi Preliminary experience with orthotopic and heterotopic transplantation of ovarian cortical strips
    Kutluk H Oktay
    Department of Reproductive Medicine, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    Semin Reprod Med 20:63-74. 2002
    ..our focus will be on the clinical applications of ovarian transplantation and new developments in heterotopic transplantation. Patient selection and screening, details of the surgical techniques, and safety measures to avoid ..
  19. ncbi Long-term ovarian function evaluation after autografting by implantation with fresh and frozen-thawed human ovarian tissue
    J Callejo
    Department of Obstetrics and Gynecology, Hospital Universitari Sant Joan de Deu, Barcelona, Spain
    J Clin Endocrinol Metab 86:4489-94. 2001
    ..The cases reported here suggest that hormonal protection can be restored after fresh or cryopreserved heterotopic ovarian transplantation in women, albeit for only a short reproductive span...
  20. ncbi Inhibin and follicular development in heterotopical ovary transplants without vascular pedicle in syngeneic Lewis rats
    Justo Callejo
    Department of Obstetrics and Gynecology, School of Medicine, Hospital Universitari Sant Joan de Deu, Barcelona, Spain
    Fertil Steril 79:743-8. 2003
    ..To evaluate the role of inhibin in elevated base levels of FSH and follicular hyperplasia in ovarian autotransplantation in rats...
  21. ncbi Follicular development, ovulation, and corpus luteum formation in cryopreserved human ovarian tissue after xenotransplantation
    S Samuel Kim
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA
    Fertil Steril 78:77-82. 2002
    ..To assess the competency of human frozen/thawed ovarian follicles matured in xenografts to form functioning corpora luteae after human chorionic gonadotropin (hCG) administration...
  22. ncbi The histology of subcutaneously implanted donor bronchial rings correlates with rejection scores of lung allografts in a primate lung transplant model
    B Hausen
    Transplantation Immunology, Department of Cardiothoracic Surgery, Stanford University, Palo Alto, California 94305 5407, USA
    J Heart Lung Transplant 18:714-24. 1999
    ....
  23. ncbi Successful human ovarian autotransplantation to the upper arm
    Carina G Hilders
    Department of Gynaecology, Leiden University Medical Center, The Netherlands
    Cancer 101:2771-8. 2004
    ..Heterotopic autotransplantation of the ovary to the upper arm is a promising surgical technique to maintain the ovarian function in women who become menopausal due to cancer treatment regimens...
  24. ncbi Attenuation of graft arterial disease by manipulation of the LIGHT pathway
    Hisanori Kosuge
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 24:1409-15. 2004
    ..To clarify the mechanism underlying graft arterial disease (GAD), we investigated the role of the LIGHT pathway in the progression of GAD...
  25. ncbi Use of lentiviral vectors to induce long-term tolerance to gal(+) heart grafts
    Mary Kearns-Jonker
    Department of Cardiothoracic Surgery, Children s Hospital of Los Angeles and the University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA
    Transplantation 77:1748-54. 2004
    ..Limitations to the success of this methodology include short-term expression of the introduced gene and rejection of gal hearts transplanted into these animals within a month...
  26. ncbi Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation model
    Isao Kondo
    Second Department of Internal Medicine, Kagawa University School of Medicine, Kita gun, Kagawa, Japan
    Circulation 109:1056-61. 2004
    ..We examined whether leukocyte-targeted myocardial contrast echocardiography (MCE) could provide for the quantitative assessment of acute cardiac rejection...
  27. ncbi KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts
    Hisashi Shimizu
    Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School, Tochigi, Japan
    Circulation 111:222-9. 2005
    ..The present study was designed to investigate the potency and safety of KRP-203 on allograft survival against both acute and chronic rejection in rat skin and heart transplantation...
  28. ncbi Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model
    Tomoyoshi Koyanagi
    Department of Chemical and Systems Biology, Stanford University School of Medicine CCSR, Rm 3145A, 269 Campus Drive Stanford, CA 94305 5174, USA
    J Mol Cell Cardiol 43:517-22. 2007
    ..after transplantation suppress allograft rejection and improve cardiac transplantation using a murine heterotopic transplantation model. Hearts of FVB mice (H-2(q)) were transplanted into C57BL/6 mice (H-2(b))...
  29. ncbi Paclitaxel saves rat heart allografts from rejection by inhibition of the primed anti-donor humoral and cellular immune response: implications for transplant patients with cancer
    Stefan Tange
    Department of Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Transpl Int 16:471-5. 2003
    ....
  30. ncbi Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody can prevent rat cardiac allograft rejection
    Yusuke Kitazawa
    Laboratory of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Heart Lung Transplant 27:362-71. 2008
    ..Therefore, therapeutic agents that capable of enhancing the number and activity of this T-cell subset are highly desirable...
  31. ncbi Serum response factor neutralizes Pur alpha- and Pur beta-mediated repression of the fetal vascular smooth muscle alpha-actin gene in stressed adult cardiomyocytes
    Aiwen Zhang
    Dept of Physiology and Cell Biology, Davis Heart and Lung Research, Institute Biomedical Research Tower, Rm 314, 460 West 12th Ave, The Ohio State Univ College of Medicine, Columbus, OH 43210 1252, USA
    Am J Physiol Cell Physiol 294:C702-14. 2008
    ....
  32. ncbi [Cardiac allograft arteriosclerosis and myocardial necrosis]
    G Song
    Department of Cardiovascular Surgery, Affiliated Hospital, Shandong Medical University, Ji'nan, China
    Zhonghua Wai Ke Za Zhi 38:303-5, 20. 2000
    ..The infiltration of collagenous fiber in the coronary arteries is one of the major causes of concentric stenosis. The pretreatment of SPC followed by CP can prevent and relieve the rejection...
  33. ncbi [Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction]
    Y Qian
    Organ Transplantation Centre, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou, China
    Zhonghua Wai Ke Za Zhi 38:306-8, 21. 2000
    ..05). CONCLUSION: The blockade B7-CD28 interaction can induce rat heterotopic heart allograft immune tolerance. It may provide a new way to treat immune rejection after transplantation...
  34. ncbi Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts
    Ping Zhou
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Am J Transplant 3:139-47. 2003
    ....
  35. ncbi Mycophenolate mofetil significantly reduces leukocyte graft infiltration after heterotopic cardiac transplantation in a rat model: comparative study with cyclosporine and FK 506
    Markus H C Richter
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Heart Lung Transplant 22:1107-16. 2003
    ..The purpose of the study was to evaluate the effects of cyclosporine (CsA), FK 506 and mycophenolate mofetil (MMF) on graft-infiltrating leukocytes (CD4, CD8, CD11a, CD18) after cardiac transplantation in rats...
  36. pmc Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection
    Koichi Shimizu
    Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 117:1997-2008. 2008
    ....
  37. ncbi Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor
    Paul S Changelian
    Immunology Group, Department of Antibacterials and Immunology, Pfizer Global Researchand Development, Groton, CT 06340, USA
    Science 302:875-8. 2003
    ..On the basis of these preclinical results, we believe JAK3 blockade by CP-690,550 has potential for therapeutically desirable immunosuppression in human organ transplantation and in other clinical settings...
  38. ncbi Combination therapy with anti-ICOS and cyclosporine enhances cardiac but not islet allograft survival
    S A Nanji
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    Transplant Proc 35:2477-8. 2003
    ....
  39. pmc The utility of right ventricular endomyocardial biopsy for the diagnosis of xenograft rejection after CD46 pig-to-baboon cardiac transplantation
    Davide Ricci
    Mayo Clinic William J von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Heart Lung Transplant 26:1025-32. 2007
    ..We also compare RV with the related left ventricle (LV) cross sections...
  40. pmc Perforin mediates endothelial cell death and resultant transplant vascular disease in cardiac allografts
    Jonathan C Choy
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Am J Pathol 165:127-33. 2004
    ..4 +/- 5.1% luminal narrowing in PKO counterparts (P < 0.00002). In summary, perforin plays a primary role in endothelial damage and the resultant onset and progression of TVD...
  41. ncbi Activation of mitogen-activated protein kinases, activator protein-1, and nuclear factor-kappaB during acute rejection after heterotopic heart transplantation in rats
    Hidekazu Hirai
    Department of Cardiovascular Surgery, Osaka City University, Graduate School of Medicine, Japan
    Osaka City Med J 52:9-19. 2006
    ..This study aimed to determine whether MAPKs and transcriptional factors such as activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) were involved in acute rejection after cardiac transplantation...
  42. ncbi [Transfection with virus interleukin-10 to prolong murine heart allograft]
    Ding Hua Yang
    Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, People s Liberation Army, Shanghai 200438, China
    Zhonghua Wai Ke Za Zhi 43:87-91. 2005
    ..To prolong murine heart allograft by modifying hematopoietic stem cells with virus interleukin-10 (vIL-10)...
  43. ncbi TLR engagement prevents transplantation tolerance
    L Chen
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Am J Transplant 6:2282-91. 2006
    ..Thus, the status of TLR signaling contributes to the resistance versus susceptibility of organs to transplantation tolerance...
  44. ncbi Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection
    Qin Ning
    Laboratory of Infectious Immunology, Department of Infectious Disease, Institute of Immunology, Huazhong University of Science and Technology, Wuhan, China
    J Immunol 174:7403-11. 2005
    ..These data collectively suggest that fgl2 accounts for the fibrin deposition seen in both experimental and human allograft rejection and provide a rationale for targeting fgl2 as adjunctive therapy to treat allograft rejection...
  45. ncbi Cardiac xenotransplantation: recent preclinical progress with 3-month median survival
    Christopher G A McGregor
    Division of Cardiovascular Surgery, Department of Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    J Thorac Cardiovasc Surg 130:844-51. 2005
    ..Overcoming the immune barrier to successful cardiac xenotransplantation is most appropriately first explored with the non-life-supporting heterotopic model...
  46. ncbi In vivo visualization of cardiac allograft rejection and trafficking passenger leukocytes using bioluminescence imaging
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Circulation 112:I105-10. 2005
    ..We investigated the feasibility of bioluminescence imaging (BLI) for the in vivo assessment of cardiac allograft viability and visualization of passenger leukocytes during the course of acute rejection...
  47. ncbi Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium
    Rutger Jan Swijnenburg
    Department of Surgery, Leiden University School of Medicine, The Netherlands
    Circulation 112:I166-72. 2005
    ..We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection...
  48. ncbi Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts
    Ingo Kutschka
    Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California, USA
    Circulation 114:I167-73. 2006
    ..Cardiac cell transplantation is limited by poor graft viability. We aimed to enhance the survival of transplanted cardiomyoblasts using growth factor-supplemented collagen matrices...
  49. ncbi Microarray-based gene expression profiling of retransplanted rat cardiac allografts that develop cardiac allograft vasculopathy
    Satoru Kitagawa-Sakakida
    Department of Molecular Pharmacology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Heart Lung Transplant 24:2068-74. 2005
    ..Microarray-based gene expression profiling has the potential to elucidate the mechanism of experimental chronic cardiac allograft rejection...
  50. ncbi Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejection
    Gordon D Wu
    Comprehensive Transplant Center, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Heart Lung Transplant 24:2160-9. 2005
    ..This study examines the role of MPC in tissue repair of heart allografts in a rat model of chronic rejection...
  51. ncbi [Long-term survival of a heterologously transplanted heart following daily administration of cyclosporin and short-term treatment with 15-deoxyspergualin]
    Taku Kubota
    Hokkaido Igaku Zasshi 79:711-7. 2004
  52. ncbi Cytoprotective gene HO-1 and chronic rejection in heart transplantation
    G T Schnickel
    Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Transplant Proc 38:3259-62. 2006
    ..Induction of HO-1 by an apoA-1 mimetic peptide was effective to control CAV. This class of antiinflammatory peptides, which show an ability to induce HO-1, provides a novel strategy for the treatment of CAV...
  53. ncbi CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo
    Akira Yamada
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:1357-64. 2005
    ..These novel findings have important implications for the development of transplantation tolerance-inducing strategies in primates and humans, in which CD8(+) T cell depletion is currently mandatory...
  54. ncbi Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons
    Stuart L Houser
    Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:416-25. 2004
    ..Acute humoral xenograft rejection (AHXR) is an immunologic barrier in pig-to-baboon organ transplantation (Tx). We report microvascular thrombosis and myocardial necrosis in a series of cardiac xenografts...
  55. ncbi Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation: induction of tolerance and prevention of cardiac allograft vasculopathy
    Kazuhiro Yamaura
    Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    Circulation 110:1650-7. 2004
    ..Recent approaches have shown that hepatocyte growth factor (HGF) exhibits cardiotrophic functions. We therefore addressed whether HGF would regulate acute and chronic rejection in cardiac transplantation...
  56. ncbi Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, CA 94305 5407, USA
    Circulation 110:II194-9. 2004
    ..Here, we examined whether limiting ischemia-reperfusion injury inhibits graft coronary artery disease (GCAD) and improves murine cardiac allografting...
  57. ncbi Spontaneous allograft tolerance in B7-deficient mice independent of preexisting endogenous CD4+CD25+ regulatory T-cells
    Todd J Grazia
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, and The Children s Hospital, Denver, CO 80262, USA
    Transplantation 83:1449-58. 2007
    ..Given this discrepancy in the literature and that the consequence of allograft exposure in B7-deficient mice is unknown; the goal of the study was to examine the antidonor status of allografted B7-1/B7-2-deficient hosts...
  58. ncbi Technique for retransplanting heterotopic heart grafts in mice
    Qi Li
    Section of Nephrology and Section of Immunobiology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 065420, USA
    Microsurgery 24:465-7. 2004
    ..This method should be useful for studying intragraft factors, such as ischemia-reperfusion injury and donor antigen-presenting cells, on the outcomes of transplantations...
  59. ncbi Heterotopic limb allotransplantation model to study skin rejection in the rat
    Jamal A Nazzal
    Division of Plastic Surgery, Harvard Medical School, Massachusetts General Hospital, 25 Fruit Street, Boston, MA 02114, USA
    Microsurgery 24:448-53. 2004
    ..6 days (without). Our heterotopic limb transplantation model takes less time and is less stressful to the animals, while allowing for early observation of graft skin rejection, when compared to orthotopic whole-limb transplantation...
  60. ncbi A new modified technique for heterotopic femoral heart transplantation in rats
    Chad R Gordon
    Division of Surgical Research, Department of Surgery, University of Medicine and Dentistry in New Jersey, Robert Wood Johnson Medical School, Cooper University Hospital, Camden, New Jersey, USA
    J Surg Res 139:157-63. 2007
    ..Rao and Lisitza developed a femoral heart accessory transplant model in 1985. Our goal was to improve this femoral model for the study of cardiac transplantation between both syngeneic and allogeneic rats...
  61. ncbi Evidence for a role of toll-like receptor 4 in development of chronic allograft rejection after cardiac transplantation
    Heiko Methe
    Department of Cardiology, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Transplantation 78:1324-31. 2004
    ..Long-term success of cardiac transplantation is limited by various forms of graft rejection. The specific mechanisms initiating and controlling these highly specialized immune processes remain unclear so far...
  62. ncbi Anti-transforming growth factor antibody at low but not high doses limits cyclosporine-mediated nephrotoxicity without altering rat cardiac allograft survival: potential of therapeutic applications
    Ashwani K Khanna
    Division of Nephrology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circulation 110:3822-9. 2004
    ..Transforming growth factor-beta (TGF-beta) is one of the most potent mediators of the fibrogenic effects of cyclosporine...
  63. ncbi Functional compartmentalization following induction of long-term graft survival with pregraft donor-specific transfusion
    D Lair
    INSERM U643, Nantes F 44000, France
    Am J Transplant 7:538-49. 2007
    ..Regulatory cells do not accumulate in blood, which appears to be a reservoir for cytotoxic T cells. Spleen T cells, which display a regulatory-like profile and transfer graft survival, are not able to prevent chronic rejection...
  64. ncbi Regulation of fibroblasts by activated and non-activated immune cells
    Cecilia Johnsson
    Department of Transplantation Surgery, University Hospital, Uppsala, Sweden
    J Heart Lung Transplant 24:2170-8. 2005
    ..Knowledge about the mechanisms behind fibroblast activation may lead to new strategies to prevent rejection. This study investigated whether cells of the immune system have the capacity to regulate fibroblast activation...
  65. ncbi The in vitro and in vivo effects of anti-galactose antibodies on endothelial cell activation and xenograft rejection
    Hui Xu
    Nextran, Princeton, NJ 08540, USA
    J Immunol 170:1531-9. 2003
    ..These studies emphasize the importance of in vivo assays, in addition to in vitro assays, in understanding the role of anti-Gal IgG-mediated tissue injury and xenograft rejection...
  66. ncbi Tolerization of Gal alpha 1,3Gal-reactive B cells in pre-sensitized alpha 1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism
    H Ohdan
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    Xenotransplantation 8:227-38. 2001
    ..The absence of B cells with receptors recognizing Gal in mixed chimeras suggests a role for clonal deletion/receptor editing in the maintenance of B cell tolerance...
  67. ncbi Improvement of heart allograft acceptability associated with recruitment of CD4+CD25+ T cells in peripheral blood by recipient treatment with granulocyte colony-stimulating factor
    H L Liang
    Department of Cardiovascular Surgery, Institute of Cardiovascular Disease, Chinese PLA, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    Transplant Proc 40:1604-11. 2008
    ..The study objective was to investigate the potential mechanism of G-CSF's antirejection effects in a fully mismatched rat cardiac allograft model...
  68. ncbi Decreasing ratios of phosphocreatine to beta-ATP correlates to progressive acute rejection in a concordant mouse heart to rat xenotransplantation model
    D J Lukes
    Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, , Sweden
    Scand J Immunol 53:171-5. 2001
    ..01). Further studies are indicated to establish the potential of (31)P MRS in immunosuppressed recipients of vascularized xenotransplants with prolonged graft survival...
  69. ncbi Intrathymic immune modulation prevents acute rejection but not the development of graft arteriosclerosis (chronic rejection)
    J L Hillebrands
    Department of Cell Biology, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Transplantation 71:914-24. 2001
    ..5x10(7) PVG splenocytes immediately followed by heterotopic transplantation of a PVG cardiac allograft (day 0). Immunosuppression consisted of 1 ml of antilymphocyte serum i.p...
  70. ncbi Analysis of transforming growth factor-beta and profibrogenic molecules in a rat cardiac allograft model treated with cyclosporine
    Ashwani K Khanna
    Department of Medicine Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
    Transplantation 73:1543-9. 2002
    ....
  71. ncbi Hyperhomocyst(e)inemia induces accelerated transplant vascular sclerosis in syngeneic and allogeneic rat cardiac transplants
    Judith W Cook
    Department of Surgery, Oregon Health and Science University, Portland 97201, USA
    Am J Transplant 2:244-51. 2002
    ..NI = 5 +/- 3, n = 10, 130d, p <0.001). hH(e) accelerated rejection and increased the severity of TVS in allogeneic cardiac transplants, and induced TVS in syngeneic cardiac transplants...
  72. ncbi Chronic rejection in H-2 matched cardiac allografts: early emergence of vasculopathy, alloantibody, and accumulation of IFN-gamma and IL-10 mRNA
    Q W Zhang
    Department of Cardiovascular Surgery, Kyushu University, Fukuoka, Japan
    Transpl Int 14:143-52. 2001
    ....
  73. ncbi Intact active bone transplantation synergizes with anti-CD40 ligand therapy to induce B cell tolerance
    Dengping Yin
    Department of General Surgery, Rush Presbyterian Hospital, St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
    J Immunol 168:5352-8. 2002
    ..This model, which does not require mixed chimerism, provides a unique opportunity for investigating the mechanism of peripheral tolerance in a clinically relevant population of carbohydrate-specific B cells...
  74. ncbi A highly selective inhibitor of Rho-associated coiled-coil forming protein kinase, Y-27632, prolongs cardiac allograft survival of the BALB/c-to-C3H/He mouse model
    S Ohki
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan
    J Heart Lung Transplant 20:956-63. 2001
    ..Inhibition of this Rho/ROCK signaling may be an alternative therapeutic option for managing acute and chronic rejection...
  75. ncbi Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis
    K Shimizu
    Departments ofMedicine and Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 165:3506-18. 2000
    ..Therefore, we propose that early alloresponses, without CD40-CD40L costimulation, induce allospecific tolerance but may trigger allo-independent mechanisms that ultimately result in graft vasculopathy...
  76. ncbi Donor cardiac allografts from p53 knockout mice exhibit apoptosis-independent prolongation of survival
    M H Kown
    Department of Cardiothoracic Surgery, Stanford University, Stanford, California 94305, USA
    Transplant Proc 34:3274-6. 2002
  77. ncbi Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig
    Cecile Guillot
    Institut national de la santé et de la recherche médicale U 437, Nantes, France
    Blood 101:3325-33. 2003
    ....
  78. ncbi Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells
    Federica Casiraghi
    Transplant Research Center, Chiara Cucchi De Alessandri and Gilberto Crespi, Ranica, Italy
    J Immunol 181:3933-46. 2008
    ....
  79. ncbi [Autologous sinoatrial node cells heterotopic transplantation for treating bradycardia: an experiment with dogs]
    Hao Zhang
    Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
    Zhonghua Yi Xue Za Zhi 87:3208-12. 2007
    To explore the feasibility of autografting sinoatrial nodal cells heterotopic transplantation to construct an ectopia pacemaker for treating bradycardia.
  80. ncbi Development and survival of thoracic motoneurons and hindlimb musculature following transplantation of the thoracic neural tube to the lumbar region in the chick embryo: functional aspects
    M K O'Brien
    Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, North Carolina 27103
    J Neurobiol 21:341-55. 1990
    Following heterotopic transplantation of the thoracic neural tube to the lumbar region on embryonic day (E) 2, the transplanted cord differentiates normally and establishes neuroanatomical connections with the host central nervous system ..
  81. ncbi Effects of inosine on reperfusion injury after heart transplantation
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 30:96-102. 2006
    ..Inosine, a break-down product of adenosine, has been recently shown to exert inodilatory and anti-inflammatory properties. We investigated the effects of inosine on ischemia/reperfusion injury in a rat heart transplantation model...
  82. ncbi Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis
    B P Davidson
    Embryology Unit, Children s Medical Research Institute, Wentworthville, New South Wales, 2145, Australia
    Dev Biol 211:11-26. 1999
    ..The node may also play a morphogenetic role since it can induce a partial body axis following heterotopic transplantation. The impact of losing these progenitor cells and the morphogenetic activity on the development of the ..
  83. ncbi The solution to hyperglucagonemia after pancreas transplantation in inbred rats
    H J Kissler
    Division of Experimental Surgery and Endocrine Research Laboratory, Department of Surgery, Friedrich Alexander University, Erlangen, Germany
    Eur Surg Res 33:370-6. 2001
    ....
  84. ncbi [The Registry of Spanish Heart Transplantation. Eleventh official report]
    L Almenar Bonet
    Sección de Trasplante Cardíaco de la Sociedad Española de Cardiología
    Rev Esp Cardiol 53:1639-45. 2000
    ..performed; high risk transplants (urgent, elderly or pediatric receptors, retransplantation, multiple heterotopic transplantation with lung, kidney and liver...) in this analysis...
  85. ncbi Rostral optic tectum acquires caudal characteristics following ectopic engrailed expression
    C Logan
    Department of Developmental Neurobiology, UMDS, Guy s Hospital, London SE1 9RT, UK
    Curr Biol 6:1006-14. 1996
    ..In heterotopic transplantation experiments, En protein expression correlates well with the subsequent gradient of cytoarchitecture as ..
  86. ncbi Altered expression of apolipoprotein E, amyloid precursor protein and presenilin-1 is associated with chronic reactive gliosis in rat cortical tissue
    R N Martins
    Sir James McCusker Alzheimer Research Unit and University Department of Surgery, The University of Western Australia, Nedlands, Austalia
    Neuroscience 106:557-69. 2001
    ..Previous rat studies demonstrated that heterotopic transplantation of foetal cortical tissue onto the midbrain of neonatal hosts resulted in sustained glial reactivity ..
  87. ncbi Heterotopic transplantation of cryopreserved tracheae in a rat model
    Erich Stoelben
    Department of Thoracic Surgery, University Hospital Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Eur J Cardiothorac Surg 23:15-20. 2003
    ..The purpose of our study was to investigate the rejection of tracheal transplants in a standardised heterotopic rat model using different forms of cryopreservation...
  88. ncbi Isthmus organizer and regionalization of the mesencephalon and metencephalon
    Harukazu Nakamura
    Department of Molecular Neurobiology, Graduate School of Life Sciences and Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Int J Dev Biol 49:231-5. 2005
    ..b>Heterotopic transplantation revealed that the diencephalon could change its fate when juxtaposed to the isthmus (mes-metencephalic ..
  89. ncbi Evaluation of the hormonal function and histological features of heterotopic isogenic ovarian transplantation in rats
    David T W Chiu
    Center for Restorative Surgery, New York, NY 10021, USA
    Plast Reconstr Surg 111:1646-52. 2003
    The purpose of the study was to determine the feasibility of preserving ovarian function after heterotopic transplantation by means of microvascular anastomosis of the transplanted vascular pedicles to a set of preselected vessels...
  90. ncbi The immunomodulatory effect of cryopreservation in rat tracheal allotransplantation
    Ryoichi Nakanishi
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Heart Lung Transplant 21:890-8. 2002
    ..Cryopreservation is one solution to the problem of donor organ deficit. To investigate the effect of cryopreservation on tracheal allografts, we performed 2 experiments in rats...
  91. ncbi Improved cardiac preservation by the addition of nitroglycerine to colloid-free University of Wisconsin solution (MUW)
    K Baxter
    Monash University, Department of Surgery, Monash Medical Centre, Melbourne, Australia
    J Heart Lung Transplant 18:769-74. 1999
    ..This study examines whether the addition of nitroglycerine, a known coronary vasodilator and nitric oxide donor, to colloid-free University of Wisconsin solution will improve and extend cardiac preservation...
  92. pmc Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejection
    Galen M Pieper
    Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 100:3125-30. 2003
    ..b>Heterotopic transplantation of donor hearts was performed in histocompatibility matched (isografts: Lewis --> Lewis) and ..
  93. ncbi Ovarian function and spontaneous pregnancy after combined heterotopic and orthotopic cryopreserved ovarian tissue transplantation in a patient previously treated with bone marrow transplantation: case report
    Isabelle Demeestere
    Research Laboratory on Human Reproduction, French Speaking Free University of Brussels, Erasme Hospital, Belgium
    Hum Reprod 21:2010-4. 2006
    ..In this article, we analyse data from the combined orthotopic and heterotopic transplantation of cryopreserved ovarian tissue that restored the ovarian function and fertility...
  94. ncbi Chronic gliosis triggers Alzheimer's disease-like processing of amyloid precursor protein
    K A Bates
    School of Anatomy and Human Biology, The University of Western Australia, Nedlands, WA 6009, Australia
    Neuroscience 113:785-96. 2002
    ..b>Heterotopic transplantation of fetal cortex onto the midbrain of neonatal mice consistently resulted in reactive gliosis, ..
  95. ncbi Molecular genetic control of axis patterning during early embryogenesis of vertebrates
    G C Schoenwolf
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City 84132, USA
    Ann N Y Acad Sci 919:246-60. 2000
    ..and dye microinjection studies are being used to generate high-resolution fate maps, and heterotopic transplantation studies are revealing the cell-cell interactions that are sufficient as well as required for mesodermal ..
  96. ncbi Mouse model of heterotopic aortic arch transplantation
    Igor Chereshnev
    Department of Medicine and the Zena and Michael Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Surg Res 111:171-6. 2003
    Syngeneic heterotopic transplantation of segments of descending thoracic aortas containing atherosclerotic lesions from hypercholesterolemic mice into normocholesterolemic recipients has been useful for studies on plaque regression and ..
  97. ncbi Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart
    Peter Razeghi
    Department of Internal Medicine, Division of Cardiology, The University of Texas Health Science Center, Houston, TX, USA
    Biochem Biophys Res Commun 342:361-4. 2006
    ..In skeletal muscle, transcript levels of proteins regulating the ubiquitin proteasome system (UPS) increase with atrophy and decrease with hypertrophy. Whether the same is true for heart muscle is not known...
  98. ncbi Orthotopic and heterotopic ovarian tissue transplantation
    Murat Sonmezer
    Ankara University School of Medicine Department of Obstetrics and Gynecology, Ankara, Turkey
    Best Pract Res Clin Obstet Gynaecol 24:113-26. 2010
    ..There are two main approaches for autotransplantation of human ovarian tissue. In the heterotopic transplantation, cortical fragments can be grafted subcutaneously at various sites whereas in orthotopic ..
  99. ncbi A technique for transplantation of ovarian cortical strips to the forearm
    Kutluk Oktay
    The Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    Fertil Steril 80:193-8. 2003
    ..To describe a forearm heterotopic ovarian transplantation technique...
  100. ncbi Mammalian neural tube grafting experiments: an in vitro system for mouse experimental embryology
    D Echevarria
    Institute of Neuroscience UMH CSIC, School of Medicine, Campus de San Juan, Spain
    Int J Dev Biol 45:895-902. 2001
    ..The first involves neuroepithelial grafting experiments by heterotopic transplantation of the zona limitans intrathalamica (ZLI) into the mesencephalon and the second consists of fibroblast ..
  101. pmc Efficient and durable gene transfer to transplanted heart using adeno-associated virus 9 vector
    Naoto Miyagi
    William J von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Heart Lung Transplant 27:554-60. 2008
    ..In this investigation we studied the efficacy and durability of recombinant adeno-associated virus serotype 9 (rAAV9) vector-mediated gene transfer to the transplanted rat heart...

Research Grants38

  1. PTLD: cytokine production and gene polymorphisms
    Robert Baiocchi; Fiscal Year: 2005
    ..Our overall goal is to use this data as a springboard for R01 proposals to study the molecular epidemiology of PTLD and to perform prospective therapeutic clinical trials in PTLD patients. ..
  2. Mentoring and Research in Mouse Models of Cancer and Infertility
    Diego H Castrillon; Fiscal Year: 2011
    ..and potentially more tractable mouse model of advanced endometrial cancer, we will develop a heterotopic transplantation model of genetically-modified Lkb1-deficient endometrium...
  3. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2004
    ..Using a unique murine model of heterotopic transplantation of HLA-A2 transgenic tracheal grafts into CD8 T cell-knockout (KO) as well as CD4 T cell-KO C57BL/6 ..
  4. Human Keratin (K14)-MBP/MBP-TCR Transgenic Animal Model
    Kouichi Ito; Fiscal Year: 2009
    ..Although broad heterogeneity is observed in thymic epithelial cells, heterotopic transplantation of purified MTS24+MHCII+CD45-TECs derived from E15...
  5. Glucose Regulated Gene Expression in the Heart
    Martin Young; Fiscal Year: 2002
    ..Through the use of both in vivo (heterotopic transplantation, aortic constriction and streptozotocin administration for the unloaded, pressure overloaded and ..
  6. Characterization of Ocular Neural Stem Cells
    Iqbal Ahmad; Fiscal Year: 2004
    ..We will use homotopic and heterotopic transplantation and in vivo activation of progenitors in response to injuries to achieve the aim...
  7. Role of integrins and activin in granulosa cell growth
    Kutluk Oktay; Fiscal Year: 2007
    ..Cell proliferation and survival will be determined before and after transfection with the dominant-negative mutants. ..
  8. Heart Xenotransplantation with Chimeric Donor Pigs
    William Beschorner; Fiscal Year: 2006
    ..Follow up studies would establish the relative contribution of tissue accommodation and specific immune tolerance to the prolongation of heart xenograft survival. ..
  9. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2009
    ..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. ..
  10. Vevo 770 High Resolution Ultrasound Imaging System
    Marielle Scherrer Crosbie; Fiscal Year: 2007
    ..We will use this machine to better understand the pathways involved in pulmonary and systemic high blood pressure, atherosclerosis, heart failure, as well as to attempt to image stem cells. [unreadable] [unreadable] [unreadable]..
  11. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 2002
    ..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets. ..
  12. Islet Transplantation with Chimeric Donor Pigs
    William Beschorner; Fiscal Year: 2007
    ..These will permit earlier detection of rejection or graft failure, and establish the safety of xenotransplantation with regards to risk of zoonotie or opportunistic infections. ..
  13. Model for the Prevention of Post-Transplant Skin Cancer
    Anne Vanbuskirk; Fiscal Year: 2005
    ..This model will provide the pre-clinical basis for new clinical trials in immunosuppressed patients, who are at extremely high risk for developing life-threatening, UV-induced SCC. ..
  14. Human/Pig Model of Hepatitis C Virus for New Vaccines
    William Beschorner; Fiscal Year: 2005
    ..A large animal immune compentent model of HCV will lead to a better understanding of the pathogenesis of hepatitis C virus and to more effective vaccines and immune therapy. ..
  15. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2005
    ....
  16. DONOR SPECIFIC IMMUNOSUPPRESSION TO TRACHEAL ALLOGRAFTS
    Eric Genden; Fiscal Year: 2004
    ..Specific Aim II will focus on alternative methods of inducing donor specific tolerance to tracheal allografts. Specific Aim III will focus on the behavior of the tracheal allograft and its affect upon the established state of tolerance. ..
  17. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2004
    ..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
  18. CELLULAR AND MOLECULAR BASIS OF MELANOCYTE MORPHOGENESIS
    CAROL ERICKSON; Fiscal Year: 2009
    ..Understanding the fundamental mechanisms by which the neural crest cells are properly positioned will allow us to understand the underlying basis of these common birth defects. ..
  19. Determinants of Epithelial Survival in Airway Allografts
    Isabel Neuringer; Fiscal Year: 2005
    ....
  20. In vivo testing of the role of TGFb in PTLD
    Anne Vanbuskirk; Fiscal Year: 2003
    ..The results from this pilot study will indicate whether TGFb is crucial to tumor formation in the SCID-Hu PBL mouse model. ..
  21. Dissecting Beta Adrenergic Signaling in Heart Failure
    Matthew Williams; Fiscal Year: 2003
    ..abstract_text> ..
  22. Pre-Conditioning Pancreatic Islets for Transplantation
    Ginny Bumgardner; Fiscal Year: 2006
    ..The effect of oxygen pre-conditioning on islet viability and function in vivo will be determined using fluorescence microscopy and the marginal mass model of islet transplantation. ..
  23. Oxidative Stress Signaling in Graft Coronary Disease
    Robert Robbins; Fiscal Year: 2004
    ..abstract_text> ..
  24. Composite Tissue Transplantation
    Thomas Tung; Fiscal Year: 2006
    ..The broad objective of this proposal is to improve the quality of reconstructive options and the quality of life for patients with devastating deformities. ..
  25. Innate Immune Responses in Obliterative Bronchiolitis
    Scott Palmer; Fiscal Year: 2006
    ..He will apply these skills to direct future investigations of patient oriented research problems in pulmonary medicine...
  26. Tolerance to Carbohydrate Antigens in Transplantation
    David Cooper; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Thromboregulation to Prevent Thrombotic Microangiopathy
    David Cooper; Fiscal Year: 2008
    ..It is anticipated that these approaches will abrogate the development of TM and allow long-term survival of pig organs in baboons. ..
  28. CMV-Specific T-Cell Immunity in Lung Transplant Recipients
    John McDyer; Fiscal Year: 2008
    ..Understanding the immune response to CMV infection in susceptible lung transplant recipients may improve our treatment strategies and ultimately impact long-term outcomes in transplant recipients. [unreadable] [unreadable] [unreadable]..
  29. Regulation of Th1 responses by IL-2 receptor blockade
    John McDyer; Fiscal Year: 2007
    ..This K08 will provide the foundation for a research career dedicated to translational studies in immunology. ..
  30. Alcohol abuse exacerbates bronchiolitis obliterans
    Patrick Mitchell; Fiscal Year: 2007
    ..This proposal has three overall goals: (1) to determine the effect of donor ethanol ingestion on OB; (2) to investigate the role of GMCSF; and (3) to investigate the role of TGFbeta1 in the pathogenesis of experimental-induced OB. ..
  31. Mesenchymal Progenitors of Intragraft Fibroblasts
    GORDON WU; Fiscal Year: 2007
    ..Completion of this research project will have defined the FP of IF and determined the migratory mechanisms by which FP home to allografts during chronic rejection. ..
  32. Manipulation of intracellular pH for treatment of NIDDM
    Subhadra Gunawardana; Fiscal Year: 2006
    ....
  33. Antigen Presentation in CD4-mediated Cardiac Rejection
    Todd Grazia; Fiscal Year: 2003
    ..endothelial cells). These chimeric mice can then serve as heart donors into immunodeficient recipients reconstituted with CD4 T-cells. Results of these studies will have significant implications for targeted therapy. ..
  34. Use of Gene Therapy to Induce Transplantation Tolerance
    Mary Kearns Jonker; Fiscal Year: 2003
    ..abstract_text> ..
  35. Mesenchymal Stem Cells in the Treatment of Lung Fibrosis
    Luis Ortiz; Fiscal Year: 2008
    ..3) To determine whether or not the systemic administration of MSCs can be used to ameliorate the fibroproliferative responses observed in the injured lung. ..