Genomes and Genes
Summary: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Publications206 found, 100 shown here
- Development of human fetal pancreas after transplantation into SCID miceZ Si
Pancreas Transplant Unit, Prince of Wales Hospital, Sydney, NSW, Australia
Cells Tissues Organs 168:147-57. 2001..We hypothesize that following the transplantation of human fetal pancreatic tissue, exocrine cells mostly transdifferentiate into duct cells and these eventually develop into endocrine cells, in particular beta cells...
- Heterotopic transplantation of the failing rat heart as a model of left ventricular mechanical unloading toward recoveryHiroshi Tsuneyoshi
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
ASAIO J 51:116-20. 2005..the functional recovery of the infarcted, failing rat heart in response to mechanical unloading after heterotopic transplantation. Heart failure was induced in Lewis rats by ligating the left anterior descending artery...
- Melatonin promotes the cumulus-oocyte complexes quality of vitrified-thawed murine ovaries; with increased mean number of follicles survival and ovary size following heterotopic transplantationMasoud Hemadi
Department of Anatomy, Faculty of Medicine, Medical Sciences University of Tehran, Tehran, Iran
Eur J Pharmacol 618:84-90. 2009..the protective effect of melatonin on neonate murine ovarian tissue after vitrification, thawing and heterotopic transplantation into ovariectomized recipient mice...
- Effect of site of transplantation on follicular development of human ovarian tissue transplanted into intact or castrated immunodeficient miceHugo Hernandez-Fonseca
Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
Fertil Steril 81:888-92. 2004..To study the response of human ovarian xenografts to transplantation into different sites and in different host conditions...
- Heterotopic ovarian transplantation without vascular pedicle in syngeneic Lewis rats: long-term evaluation of effects on ovarian structure and functionJusto Callejo
Department of Obstetrics and Gynecology, Faculty of Medicine, Hospital Universitari Sant Joan de Deu, University of Barcelona, 08950 Esplugues, Barcelona, Spain
Fertil Steril 77:396-402. 2002..To assess the long-term efficacy of intraperitoneal (IP) and subcutaneous (SC) ovarian autotransplantation in rats...
- A new mouse model for intraportal islet transplantation with limited hepatic lobe as a graft siteYukihide Yonekawa
Department of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Transplantation 82:712-5. 2006..This model can be applied to investigate both the specific graft-recipient interaction in the liver and the islet graft contribution to the control of diabetes...
- Graft site and gonadotrophin stimulation influences the number and quality of oocytes from murine ovarian tissue graftsHsiao Yun Yang
Department of Physiology, Monash Medical Centre, Clayton, Australia 3168
Reproduction 131:851-9. 2006..In conclusion, graft site affects the number and quality of oocytes produced from ovarian grafts...
- Follicular growth in fresh and cryopreserved human ovarian cortical grafts transplanted to immunodeficient miceR Van den Broecke
Department of Gynaecologic Oncology, Infertility Centre, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
Eur J Obstet Gynecol Reprod Biol 97:193-201. 2001..To investigate follicle growth in fresh and cryopreserved human ovarian cortical grafts transplanted to immunodeficient mice...
- Embryo development after heterotopic transplantation of cryopreserved ovarian tissueKutluk Oktay
Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, 505 East 70th Street, HT 340, New York, NY 10021, USA
Lancet 363:837-40. 2004..One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplantation of ovarian tissue...
- Implantation site-dependent dysfunction of transplanted pancreatic isletsJoey Lau
Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden
Diabetes 56:1544-50. 2007..Clinical islet transplantations are performed through infusion of islets via the portal vein into the liver. This study aimed at characterizing the influence of the implantation microenvironment on islet graft metabolism and function...
- Development of antral follicles in human cryopreserved ovarian tissue following xenograftingD A Gook
Reproductive Biology Unit, Royal Women s Hospital, Australia
Hum Reprod 16:417-22. 2001..Pedicles containing germinal vesicle oocytes were observed protruding from the granulosa cell layers. The development and morphology of the cryopreserved and fresh tissue following grafting was similar...
- Offspring produced from heterotopic ovarian allografts in male and female recipient miceTracey Waterhouse
Department of Physiology, Monash University, Victoria 3800, Australia
Reproduction 127:689-94. 2004..In conclusion, this work has shown that the hormonal environment of male mice can support the growth of oocytes in ovarian allografts and that these oocytes can produce live offspring...
- Heterotopic autotransplantation of the ovary with microvascular anastomosis: a novel surgical techniqueElisabeth Jeremias
Department of Obstetrics and Gynecology, Minimally Invasive Surgery Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Fertil Steril 77:1278-82. 2002..To test the feasibility of transplanting an entire ovary with anastomosis of the ovarian vascular pedicle...
- Spontaneous conceptions and live birth after heterotopic ovarian transplantation: is there a germline stem cell connection?Kutluk Oktay
Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY 10021, USA
Hum Reprod 21:1345-8. 2006....
- Blockade of complement inhibits obliterative bronchiolitis in rat tracheal allograftsE A Kallio
Cardiopulmonary Research Group of the Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Am J Respir Crit Care Med 161:1332-9. 2000..A blockade of complement activation renders the chemokine milieu unattractive to neutrophils and also modulates the alloimmune response toward Th2 cytokines, which may have an antiproliferative role in fibroproliferative disorders...
- Functional studies of subcutaneous ovarian transplants in non-human primates: steroidogenesis, endometrial development, ovulation, menstrual patterns and gamete morphologyJohn Schnorr
Department of Obstetrics and Gynecology, The Howard and Georgeanna Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, VA 23507, USA
Hum Reprod 17:612-9. 2002....
- Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin's diseaseIsabelle Demeestere
Research Laboratory on Human Reproduction, Campus Erasme Bat GE CP636, 808 Route de Lennik, 1070, Brussels, Belgium
Oncologist 12:1437-42. 2007..Here, we describe the second published full-term spontaneous pregnancy after an orthotopic and heterotopic transplantation of cryopreserved ovarian tissue in a 31-year-old woman previously treated by conditioning therapy for ..
- Preliminary experience with orthotopic and heterotopic transplantation of ovarian cortical stripsKutluk H Oktay
Department of Reproductive Medicine, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
Semin Reprod Med 20:63-74. 2002..our focus will be on the clinical applications of ovarian transplantation and new developments in heterotopic transplantation. Patient selection and screening, details of the surgical techniques, and safety measures to avoid ..
- Long-term ovarian function evaluation after autografting by implantation with fresh and frozen-thawed human ovarian tissueJ Callejo
Department of Obstetrics and Gynecology, Hospital Universitari Sant Joan de Deu, Barcelona, Spain
J Clin Endocrinol Metab 86:4489-94. 2001..The cases reported here suggest that hormonal protection can be restored after fresh or cryopreserved heterotopic ovarian transplantation in women, albeit for only a short reproductive span...
- Inhibin and follicular development in heterotopical ovary transplants without vascular pedicle in syngeneic Lewis ratsJusto Callejo
Department of Obstetrics and Gynecology, School of Medicine, Hospital Universitari Sant Joan de Deu, Barcelona, Spain
Fertil Steril 79:743-8. 2003..To evaluate the role of inhibin in elevated base levels of FSH and follicular hyperplasia in ovarian autotransplantation in rats...
- Follicular development, ovulation, and corpus luteum formation in cryopreserved human ovarian tissue after xenotransplantationS Samuel Kim
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA
Fertil Steril 78:77-82. 2002..To assess the competency of human frozen/thawed ovarian follicles matured in xenografts to form functioning corpora luteae after human chorionic gonadotropin (hCG) administration...
- The histology of subcutaneously implanted donor bronchial rings correlates with rejection scores of lung allografts in a primate lung transplant modelB Hausen
Transplantation Immunology, Department of Cardiothoracic Surgery, Stanford University, Palo Alto, California 94305 5407, USA
J Heart Lung Transplant 18:714-24. 1999....
- Successful human ovarian autotransplantation to the upper armCarina G Hilders
Department of Gynaecology, Leiden University Medical Center, The Netherlands
Cancer 101:2771-8. 2004..Heterotopic autotransplantation of the ovary to the upper arm is a promising surgical technique to maintain the ovarian function in women who become menopausal due to cancer treatment regimens...
- Attenuation of graft arterial disease by manipulation of the LIGHT pathwayHisanori Kosuge
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Arterioscler Thromb Vasc Biol 24:1409-15. 2004..To clarify the mechanism underlying graft arterial disease (GAD), we investigated the role of the LIGHT pathway in the progression of GAD...
- Use of lentiviral vectors to induce long-term tolerance to gal(+) heart graftsMary Kearns-Jonker
Department of Cardiothoracic Surgery, Children s Hospital of Los Angeles and the University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA
Transplantation 77:1748-54. 2004..Limitations to the success of this methodology include short-term expression of the introduced gene and rejection of gal hearts transplanted into these animals within a month...
- Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation modelIsao Kondo
Second Department of Internal Medicine, Kagawa University School of Medicine, Kita gun, Kagawa, Japan
Circulation 109:1056-61. 2004..We examined whether leukocyte-targeted myocardial contrast echocardiography (MCE) could provide for the quantitative assessment of acute cardiac rejection...
- KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allograftsHisashi Shimizu
Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School, Tochigi, Japan
Circulation 111:222-9. 2005..The present study was designed to investigate the potency and safety of KRP-203 on allograft survival against both acute and chronic rejection in rat skin and heart transplantation...
- Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation modelTomoyoshi Koyanagi
Department of Chemical and Systems Biology, Stanford University School of Medicine CCSR, Rm 3145A, 269 Campus Drive Stanford, CA 94305 5174, USA
J Mol Cell Cardiol 43:517-22. 2007..after transplantation suppress allograft rejection and improve cardiac transplantation using a murine heterotopic transplantation model. Hearts of FVB mice (H-2(q)) were transplanted into C57BL/6 mice (H-2(b))...
- Paclitaxel saves rat heart allografts from rejection by inhibition of the primed anti-donor humoral and cellular immune response: implications for transplant patients with cancerStefan Tange
Department of Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
Transpl Int 16:471-5. 2003....
- Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody can prevent rat cardiac allograft rejectionYusuke Kitazawa
Laboratory of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
J Heart Lung Transplant 27:362-71. 2008..Therefore, therapeutic agents that capable of enhancing the number and activity of this T-cell subset are highly desirable...
- Serum response factor neutralizes Pur alpha- and Pur beta-mediated repression of the fetal vascular smooth muscle alpha-actin gene in stressed adult cardiomyocytesAiwen Zhang
Dept of Physiology and Cell Biology, Davis Heart and Lung Research, Institute Biomedical Research Tower, Rm 314, 460 West 12th Ave, The Ohio State Univ College of Medicine, Columbus, OH 43210 1252, USA
Am J Physiol Cell Physiol 294:C702-14. 2008....
- [Cardiac allograft arteriosclerosis and myocardial necrosis]G Song
Department of Cardiovascular Surgery, Affiliated Hospital, Shandong Medical University, Ji'nan, China
Zhonghua Wai Ke Za Zhi 38:303-5, 20. 2000..The infiltration of collagenous fiber in the coronary arteries is one of the major causes of concentric stenosis. The pretreatment of SPC followed by CP can prevent and relieve the rejection...
- [Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction]Y Qian
Organ Transplantation Centre, First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou, China
Zhonghua Wai Ke Za Zhi 38:306-8, 21. 2000..05). CONCLUSION: The blockade B7-CD28 interaction can induce rat heterotopic heart allograft immune tolerance. It may provide a new way to treat immune rejection after transplantation...
- Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin graftsPing Zhou
Department of Medicine, University of Chicago, Chicago, IL, USA
Am J Transplant 3:139-47. 2003....
- Mycophenolate mofetil significantly reduces leukocyte graft infiltration after heterotopic cardiac transplantation in a rat model: comparative study with cyclosporine and FK 506Markus H C Richter
Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
J Heart Lung Transplant 22:1107-16. 2003..The purpose of the study was to evaluate the effects of cyclosporine (CsA), FK 506 and mycophenolate mofetil (MMF) on graft-infiltrating leukocytes (CD4, CD8, CD11a, CD18) after cardiac transplantation in rats...
- Leukocyte integrin Mac-1 promotes acute cardiac allograft rejectionKoichi Shimizu
Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 117:1997-2008. 2008....
- Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitorPaul S Changelian
Immunology Group, Department of Antibacterials and Immunology, Pfizer Global Researchand Development, Groton, CT 06340, USA
Science 302:875-8. 2003..On the basis of these preclinical results, we believe JAK3 blockade by CP-690,550 has potential for therapeutically desirable immunosuppression in human organ transplantation and in other clinical settings...
- Combination therapy with anti-ICOS and cyclosporine enhances cardiac but not islet allograft survivalS A Nanji
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
Transplant Proc 35:2477-8. 2003....
- The utility of right ventricular endomyocardial biopsy for the diagnosis of xenograft rejection after CD46 pig-to-baboon cardiac transplantationDavide Ricci
Mayo Clinic William J von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Heart Lung Transplant 26:1025-32. 2007..We also compare RV with the related left ventricle (LV) cross sections...
- Perforin mediates endothelial cell death and resultant transplant vascular disease in cardiac allograftsJonathan C Choy
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Am J Pathol 165:127-33. 2004..4 +/- 5.1% luminal narrowing in PKO counterparts (P < 0.00002). In summary, perforin plays a primary role in endothelial damage and the resultant onset and progression of TVD...
- Activation of mitogen-activated protein kinases, activator protein-1, and nuclear factor-kappaB during acute rejection after heterotopic heart transplantation in ratsHidekazu Hirai
Department of Cardiovascular Surgery, Osaka City University, Graduate School of Medicine, Japan
Osaka City Med J 52:9-19. 2006..This study aimed to determine whether MAPKs and transcriptional factors such as activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) were involved in acute rejection after cardiac transplantation...
- [Transfection with virus interleukin-10 to prolong murine heart allograft]Ding Hua Yang
Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, People s Liberation Army, Shanghai 200438, China
Zhonghua Wai Ke Za Zhi 43:87-91. 2005..To prolong murine heart allograft by modifying hematopoietic stem cells with virus interleukin-10 (vIL-10)...
- TLR engagement prevents transplantation toleranceL Chen
Department of Medicine, The University of Chicago, Chicago, Illinois, USA
Am J Transplant 6:2282-91. 2006..Thus, the status of TLR signaling contributes to the resistance versus susceptibility of organs to transplantation tolerance...
- Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejectionQin Ning
Laboratory of Infectious Immunology, Department of Infectious Disease, Institute of Immunology, Huazhong University of Science and Technology, Wuhan, China
J Immunol 174:7403-11. 2005..These data collectively suggest that fgl2 accounts for the fibrin deposition seen in both experimental and human allograft rejection and provide a rationale for targeting fgl2 as adjunctive therapy to treat allograft rejection...
- Cardiac xenotransplantation: recent preclinical progress with 3-month median survivalChristopher G A McGregor
Division of Cardiovascular Surgery, Department of Surgery, Mayo Clinic, Rochester, Minn 55905, USA
J Thorac Cardiovasc Surg 130:844-51. 2005..Overcoming the immune barrier to successful cardiac xenotransplantation is most appropriately first explored with the non-life-supporting heterotopic model...
- In vivo visualization of cardiac allograft rejection and trafficking passenger leukocytes using bioluminescence imagingMasashi Tanaka
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
Circulation 112:I105-10. 2005..We investigated the feasibility of bioluminescence imaging (BLI) for the in vivo assessment of cardiac allograft viability and visualization of passenger leukocytes during the course of acute rejection...
- Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardiumRutger Jan Swijnenburg
Department of Surgery, Leiden University School of Medicine, The Netherlands
Circulation 112:I166-72. 2005..We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection...
- Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat heartsIngo Kutschka
Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California, USA
Circulation 114:I167-73. 2006..Cardiac cell transplantation is limited by poor graft viability. We aimed to enhance the survival of transplanted cardiomyoblasts using growth factor-supplemented collagen matrices...
- Microarray-based gene expression profiling of retransplanted rat cardiac allografts that develop cardiac allograft vasculopathySatoru Kitagawa-Sakakida
Department of Molecular Pharmacology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
J Heart Lung Transplant 24:2068-74. 2005..Microarray-based gene expression profiling has the potential to elucidate the mechanism of experimental chronic cardiac allograft rejection...
- Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejectionGordon D Wu
Comprehensive Transplant Center, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
J Heart Lung Transplant 24:2160-9. 2005..This study examines the role of MPC in tissue repair of heart allografts in a rat model of chronic rejection...
- [Long-term survival of a heterologously transplanted heart following daily administration of cyclosporin and short-term treatment with 15-deoxyspergualin]Taku Kubota
Hokkaido Igaku Zasshi 79:711-7. 2004
- Cytoprotective gene HO-1 and chronic rejection in heart transplantationG T Schnickel
Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
Transplant Proc 38:3259-62. 2006..Induction of HO-1 by an apoA-1 mimetic peptide was effective to control CAV. This class of antiinflammatory peptides, which show an ability to induce HO-1, provides a novel strategy for the treatment of CAV...
- CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivoAkira Yamada
Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:1357-64. 2005..These novel findings have important implications for the development of transplantation tolerance-inducing strategies in primates and humans, in which CD8(+) T cell depletion is currently mandatory...
- Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboonsStuart L Houser
Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Xenotransplantation 11:416-25. 2004..Acute humoral xenograft rejection (AHXR) is an immunologic barrier in pig-to-baboon organ transplantation (Tx). We report microvascular thrombosis and myocardial necrosis in a series of cardiac xenografts...
- Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation: induction of tolerance and prevention of cardiac allograft vasculopathyKazuhiro Yamaura
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
Circulation 110:1650-7. 2004..Recent approaches have shown that hepatocyte growth factor (HGF) exhibits cardiotrophic functions. We therefore addressed whether HGF would regulate acute and chronic rejection in cardiac transplantation...
- Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allograftsMasashi Tanaka
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, CA 94305 5407, USA
Circulation 110:II194-9. 2004..Here, we examined whether limiting ischemia-reperfusion injury inhibits graft coronary artery disease (GCAD) and improves murine cardiac allografting...
- Spontaneous allograft tolerance in B7-deficient mice independent of preexisting endogenous CD4+CD25+ regulatory T-cellsTodd J Grazia
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, and The Children s Hospital, Denver, CO 80262, USA
Transplantation 83:1449-58. 2007..Given this discrepancy in the literature and that the consequence of allograft exposure in B7-deficient mice is unknown; the goal of the study was to examine the antidonor status of allografted B7-1/B7-2-deficient hosts...
- Technique for retransplanting heterotopic heart grafts in miceQi Li
Section of Nephrology and Section of Immunobiology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 065420, USA
Microsurgery 24:465-7. 2004..This method should be useful for studying intragraft factors, such as ischemia-reperfusion injury and donor antigen-presenting cells, on the outcomes of transplantations...
- Heterotopic limb allotransplantation model to study skin rejection in the ratJamal A Nazzal
Division of Plastic Surgery, Harvard Medical School, Massachusetts General Hospital, 25 Fruit Street, Boston, MA 02114, USA
Microsurgery 24:448-53. 2004..6 days (without). Our heterotopic limb transplantation model takes less time and is less stressful to the animals, while allowing for early observation of graft skin rejection, when compared to orthotopic whole-limb transplantation...
- A new modified technique for heterotopic femoral heart transplantation in ratsChad R Gordon
Division of Surgical Research, Department of Surgery, University of Medicine and Dentistry in New Jersey, Robert Wood Johnson Medical School, Cooper University Hospital, Camden, New Jersey, USA
J Surg Res 139:157-63. 2007..Rao and Lisitza developed a femoral heart accessory transplant model in 1985. Our goal was to improve this femoral model for the study of cardiac transplantation between both syngeneic and allogeneic rats...
- Evidence for a role of toll-like receptor 4 in development of chronic allograft rejection after cardiac transplantationHeiko Methe
Department of Cardiology, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
Transplantation 78:1324-31. 2004..Long-term success of cardiac transplantation is limited by various forms of graft rejection. The specific mechanisms initiating and controlling these highly specialized immune processes remain unclear so far...
- Anti-transforming growth factor antibody at low but not high doses limits cyclosporine-mediated nephrotoxicity without altering rat cardiac allograft survival: potential of therapeutic applicationsAshwani K Khanna
Division of Nephrology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Circulation 110:3822-9. 2004..Transforming growth factor-beta (TGF-beta) is one of the most potent mediators of the fibrogenic effects of cyclosporine...
- Functional compartmentalization following induction of long-term graft survival with pregraft donor-specific transfusionD Lair
INSERM U643, Nantes F 44000, France
Am J Transplant 7:538-49. 2007..Regulatory cells do not accumulate in blood, which appears to be a reservoir for cytotoxic T cells. Spleen T cells, which display a regulatory-like profile and transfer graft survival, are not able to prevent chronic rejection...
- Regulation of fibroblasts by activated and non-activated immune cellsCecilia Johnsson
Department of Transplantation Surgery, University Hospital, Uppsala, Sweden
J Heart Lung Transplant 24:2170-8. 2005..Knowledge about the mechanisms behind fibroblast activation may lead to new strategies to prevent rejection. This study investigated whether cells of the immune system have the capacity to regulate fibroblast activation...
- The in vitro and in vivo effects of anti-galactose antibodies on endothelial cell activation and xenograft rejectionHui Xu
Nextran, Princeton, NJ 08540, USA
J Immunol 170:1531-9. 2003..These studies emphasize the importance of in vivo assays, in addition to in vitro assays, in understanding the role of anti-Gal IgG-mediated tissue injury and xenograft rejection...
- Tolerization of Gal alpha 1,3Gal-reactive B cells in pre-sensitized alpha 1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerismH Ohdan
Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
Xenotransplantation 8:227-38. 2001..The absence of B cells with receptors recognizing Gal in mixed chimeras suggests a role for clonal deletion/receptor editing in the maintenance of B cell tolerance...
- Improvement of heart allograft acceptability associated with recruitment of CD4+CD25+ T cells in peripheral blood by recipient treatment with granulocyte colony-stimulating factorH L Liang
Department of Cardiovascular Surgery, Institute of Cardiovascular Disease, Chinese PLA, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, China
Transplant Proc 40:1604-11. 2008..The study objective was to investigate the potential mechanism of G-CSF's antirejection effects in a fully mismatched rat cardiac allograft model...
- Decreasing ratios of phosphocreatine to beta-ATP correlates to progressive acute rejection in a concordant mouse heart to rat xenotransplantation modelD J Lukes
Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, , Sweden
Scand J Immunol 53:171-5. 2001..01). Further studies are indicated to establish the potential of (31)P MRS in immunosuppressed recipients of vascularized xenotransplants with prolonged graft survival...
- Intrathymic immune modulation prevents acute rejection but not the development of graft arteriosclerosis (chronic rejection)J L Hillebrands
Department of Cell Biology, Faculty of Medical Sciences, University of Groningen, The Netherlands
Transplantation 71:914-24. 2001..5x10(7) PVG splenocytes immediately followed by heterotopic transplantation of a PVG cardiac allograft (day 0). Immunosuppression consisted of 1 ml of antilymphocyte serum i.p...
- Analysis of transforming growth factor-beta and profibrogenic molecules in a rat cardiac allograft model treated with cyclosporineAshwani K Khanna
Department of Medicine Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin 53215, USA
Transplantation 73:1543-9. 2002....
- Hyperhomocyst(e)inemia induces accelerated transplant vascular sclerosis in syngeneic and allogeneic rat cardiac transplantsJudith W Cook
Department of Surgery, Oregon Health and Science University, Portland 97201, USA
Am J Transplant 2:244-51. 2002..NI = 5 +/- 3, n = 10, 130d, p <0.001). hH(e) accelerated rejection and increased the severity of TVS in allogeneic cardiac transplants, and induced TVS in syngeneic cardiac transplants...
- Chronic rejection in H-2 matched cardiac allografts: early emergence of vasculopathy, alloantibody, and accumulation of IFN-gamma and IL-10 mRNAQ W Zhang
Department of Cardiovascular Surgery, Kyushu University, Fukuoka, Japan
Transpl Int 14:143-52. 2001....
- Intact active bone transplantation synergizes with anti-CD40 ligand therapy to induce B cell toleranceDengping Yin
Department of General Surgery, Rush Presbyterian Hospital, St Luke s Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
J Immunol 168:5352-8. 2002..This model, which does not require mixed chimerism, provides a unique opportunity for investigating the mechanism of peripheral tolerance in a clinically relevant population of carbohydrate-specific B cells...
- A highly selective inhibitor of Rho-associated coiled-coil forming protein kinase, Y-27632, prolongs cardiac allograft survival of the BALB/c-to-C3H/He mouse modelS Ohki
Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan
J Heart Lung Transplant 20:956-63. 2001..Inhibition of this Rho/ROCK signaling may be an alternative therapeutic option for managing acute and chronic rejection...
- Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosisK Shimizu
Departments ofMedicine and Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 165:3506-18. 2000..Therefore, we propose that early alloresponses, without CD40-CD40L costimulation, induce allospecific tolerance but may trigger allo-independent mechanisms that ultimately result in graft vasculopathy...
- Donor cardiac allografts from p53 knockout mice exhibit apoptosis-independent prolongation of survivalM H Kown
Department of Cardiothoracic Surgery, Stanford University, Stanford, California 94305, USA
Transplant Proc 34:3274-6. 2002
- Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4IgCecile Guillot
Institut national de la santé et de la recherche médicale U 437, Nantes, France
Blood 101:3325-33. 2003....
- Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cellsFederica Casiraghi
Transplant Research Center, Chiara Cucchi De Alessandri and Gilberto Crespi, Ranica, Italy
J Immunol 181:3933-46. 2008....
- [Autologous sinoatrial node cells heterotopic transplantation for treating bradycardia: an experiment with dogs]Hao Zhang
Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
Zhonghua Yi Xue Za Zhi 87:3208-12. 2007To explore the feasibility of autografting sinoatrial nodal cells heterotopic transplantation to construct an ectopia pacemaker for treating bradycardia.
- Development and survival of thoracic motoneurons and hindlimb musculature following transplantation of the thoracic neural tube to the lumbar region in the chick embryo: functional aspectsM K O'Brien
Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, North Carolina 27103
J Neurobiol 21:341-55. 1990Following heterotopic transplantation of the thoracic neural tube to the lumbar region on embryonic day (E) 2, the transplanted cord differentiates normally and establishes neuroanatomical connections with the host central nervous system ..
- Effects of inosine on reperfusion injury after heart transplantationGabor Szabo
Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany
Eur J Cardiothorac Surg 30:96-102. 2006..Inosine, a break-down product of adenosine, has been recently shown to exert inodilatory and anti-inflammatory properties. We investigated the effects of inosine on ischemia/reperfusion injury in a rat heart transplantation model...
- Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesisB P Davidson
Embryology Unit, Children s Medical Research Institute, Wentworthville, New South Wales, 2145, Australia
Dev Biol 211:11-26. 1999..The node may also play a morphogenetic role since it can induce a partial body axis following heterotopic transplantation. The impact of losing these progenitor cells and the morphogenetic activity on the development of the ..
- The solution to hyperglucagonemia after pancreas transplantation in inbred ratsH J Kissler
Division of Experimental Surgery and Endocrine Research Laboratory, Department of Surgery, Friedrich Alexander University, Erlangen, Germany
Eur Surg Res 33:370-6. 2001....
- [The Registry of Spanish Heart Transplantation. Eleventh official report]L Almenar Bonet
Sección de Trasplante Cardíaco de la Sociedad Española de Cardiología
Rev Esp Cardiol 53:1639-45. 2000..performed; high risk transplants (urgent, elderly or pediatric receptors, retransplantation, multiple heterotopic transplantation with lung, kidney and liver...) in this analysis...
- Rostral optic tectum acquires caudal characteristics following ectopic engrailed expressionC Logan
Department of Developmental Neurobiology, UMDS, Guy s Hospital, London SE1 9RT, UK
Curr Biol 6:1006-14. 1996..In heterotopic transplantation experiments, En protein expression correlates well with the subsequent gradient of cytoarchitecture as ..
- Altered expression of apolipoprotein E, amyloid precursor protein and presenilin-1 is associated with chronic reactive gliosis in rat cortical tissueR N Martins
Sir James McCusker Alzheimer Research Unit and University Department of Surgery, The University of Western Australia, Nedlands, Austalia
Neuroscience 106:557-69. 2001..Previous rat studies demonstrated that heterotopic transplantation of foetal cortical tissue onto the midbrain of neonatal hosts resulted in sustained glial reactivity ..
- Heterotopic transplantation of cryopreserved tracheae in a rat modelErich Stoelben
Department of Thoracic Surgery, University Hospital Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
Eur J Cardiothorac Surg 23:15-20. 2003..The purpose of our study was to investigate the rejection of tracheal transplants in a standardised heterotopic rat model using different forms of cryopreservation...
- Isthmus organizer and regionalization of the mesencephalon and metencephalonHarukazu Nakamura
Department of Molecular Neurobiology, Graduate School of Life Sciences and Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
Int J Dev Biol 49:231-5. 2005..b>Heterotopic transplantation revealed that the diencephalon could change its fate when juxtaposed to the isthmus (mes-metencephalic ..
- Evaluation of the hormonal function and histological features of heterotopic isogenic ovarian transplantation in ratsDavid T W Chiu
Center for Restorative Surgery, New York, NY 10021, USA
Plast Reconstr Surg 111:1646-52. 2003The purpose of the study was to determine the feasibility of preserving ovarian function after heterotopic transplantation by means of microvascular anastomosis of the transplanted vascular pedicles to a set of preselected vessels...
- The immunomodulatory effect of cryopreservation in rat tracheal allotransplantationRyoichi Nakanishi
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
J Heart Lung Transplant 21:890-8. 2002..Cryopreservation is one solution to the problem of donor organ deficit. To investigate the effect of cryopreservation on tracheal allografts, we performed 2 experiments in rats...
- Improved cardiac preservation by the addition of nitroglycerine to colloid-free University of Wisconsin solution (MUW)K Baxter
Monash University, Department of Surgery, Monash Medical Centre, Melbourne, Australia
J Heart Lung Transplant 18:769-74. 1999..This study examines whether the addition of nitroglycerine, a known coronary vasodilator and nitric oxide donor, to colloid-free University of Wisconsin solution will improve and extend cardiac preservation...
- Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejectionGalen M Pieper
Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
Proc Natl Acad Sci U S A 100:3125-30. 2003..b>Heterotopic transplantation of donor hearts was performed in histocompatibility matched (isografts: Lewis --> Lewis) and ..
- Ovarian function and spontaneous pregnancy after combined heterotopic and orthotopic cryopreserved ovarian tissue transplantation in a patient previously treated with bone marrow transplantation: case reportIsabelle Demeestere
Research Laboratory on Human Reproduction, French Speaking Free University of Brussels, Erasme Hospital, Belgium
Hum Reprod 21:2010-4. 2006..In this article, we analyse data from the combined orthotopic and heterotopic transplantation of cryopreserved ovarian tissue that restored the ovarian function and fertility...
- Chronic gliosis triggers Alzheimer's disease-like processing of amyloid precursor proteinK A Bates
School of Anatomy and Human Biology, The University of Western Australia, Nedlands, WA 6009, Australia
Neuroscience 113:785-96. 2002..b>Heterotopic transplantation of fetal cortex onto the midbrain of neonatal mice consistently resulted in reactive gliosis, ..
- Molecular genetic control of axis patterning during early embryogenesis of vertebratesG C Schoenwolf
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City 84132, USA
Ann N Y Acad Sci 919:246-60. 2000..and dye microinjection studies are being used to generate high-resolution fate maps, and heterotopic transplantation studies are revealing the cell-cell interactions that are sufficient as well as required for mesodermal ..
- Mouse model of heterotopic aortic arch transplantationIgor Chereshnev
Department of Medicine and the Zena and Michael Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
J Surg Res 111:171-6. 2003Syngeneic heterotopic transplantation of segments of descending thoracic aortas containing atherosclerotic lesions from hypercholesterolemic mice into normocholesterolemic recipients has been useful for studies on plaque regression and ..
- Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heartPeter Razeghi
Department of Internal Medicine, Division of Cardiology, The University of Texas Health Science Center, Houston, TX, USA
Biochem Biophys Res Commun 342:361-4. 2006..In skeletal muscle, transcript levels of proteins regulating the ubiquitin proteasome system (UPS) increase with atrophy and decrease with hypertrophy. Whether the same is true for heart muscle is not known...
- Orthotopic and heterotopic ovarian tissue transplantationMurat Sonmezer
Ankara University School of Medicine Department of Obstetrics and Gynecology, Ankara, Turkey
Best Pract Res Clin Obstet Gynaecol 24:113-26. 2010..There are two main approaches for autotransplantation of human ovarian tissue. In the heterotopic transplantation, cortical fragments can be grafted subcutaneously at various sites whereas in orthotopic ..
- A technique for transplantation of ovarian cortical strips to the forearmKutluk Oktay
The Center for Reproductive Medicine and Infertility, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
Fertil Steril 80:193-8. 2003..To describe a forearm heterotopic ovarian transplantation technique...
- Mammalian neural tube grafting experiments: an in vitro system for mouse experimental embryologyD Echevarria
Institute of Neuroscience UMH CSIC, School of Medicine, Campus de San Juan, Spain
Int J Dev Biol 45:895-902. 2001..The first involves neuroepithelial grafting experiments by heterotopic transplantation of the zona limitans intrathalamica (ZLI) into the mesencephalon and the second consists of fibroblast ..
- Efficient and durable gene transfer to transplanted heart using adeno-associated virus 9 vectorNaoto Miyagi
William J von Liebig Transplant Center, Mayo Clinic, Rochester, Minnesota 55905, USA
J Heart Lung Transplant 27:554-60. 2008..In this investigation we studied the efficacy and durability of recombinant adeno-associated virus serotype 9 (rAAV9) vector-mediated gene transfer to the transplanted rat heart...
- PTLD: cytokine production and gene polymorphismsRobert Baiocchi; Fiscal Year: 2005..Our overall goal is to use this data as a springboard for R01 proposals to study the molecular epidemiology of PTLD and to perform prospective therapeutic clinical trials in PTLD patients. ..
- Mentoring and Research in Mouse Models of Cancer and InfertilityDiego H Castrillon; Fiscal Year: 2011..and potentially more tractable mouse model of advanced endometrial cancer, we will develop a heterotopic transplantation model of genetically-modified Lkb1-deficient endometrium...
- PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANSThalachallour Mohanakumar; Fiscal Year: 2004..Using a unique murine model of heterotopic transplantation of HLA-A2 transgenic tracheal grafts into CD8 T cell-knockout (KO) as well as CD4 T cell-KO C57BL/6 ..
- Human Keratin (K14)-MBP/MBP-TCR Transgenic Animal ModelKouichi Ito; Fiscal Year: 2009..Although broad heterogeneity is observed in thymic epithelial cells, heterotopic transplantation of purified MTS24+MHCII+CD45-TECs derived from E15...
- Glucose Regulated Gene Expression in the HeartMartin Young; Fiscal Year: 2002..Through the use of both in vivo (heterotopic transplantation, aortic constriction and streptozotocin administration for the unloaded, pressure overloaded and ..
- Characterization of Ocular Neural Stem CellsIqbal Ahmad; Fiscal Year: 2004..We will use homotopic and heterotopic transplantation and in vivo activation of progenitors in response to injuries to achieve the aim...
- Role of integrins and activin in granulosa cell growthKutluk Oktay; Fiscal Year: 2007..Cell proliferation and survival will be determined before and after transfection with the dominant-negative mutants. ..
- Heart Xenotransplantation with Chimeric Donor PigsWilliam Beschorner; Fiscal Year: 2006..Follow up studies would establish the relative contribution of tissue accommodation and specific immune tolerance to the prolongation of heart xenograft survival. ..
- iNOS Posttranslational Regulation in Cardiac RejectionGALEN PIEPER; Fiscal Year: 2009..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. ..
- Vevo 770 High Resolution Ultrasound Imaging SystemMarielle Scherrer Crosbie; Fiscal Year: 2007..We will use this machine to better understand the pathways involved in pulmonary and systemic high blood pressure, atherosclerosis, heart failure, as well as to attempt to image stem cells. [unreadable] [unreadable] [unreadable]..
- TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICEMartin Zand; Fiscal Year: 2002..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets. ..
- Islet Transplantation with Chimeric Donor PigsWilliam Beschorner; Fiscal Year: 2007..These will permit earlier detection of rejection or graft failure, and establish the safety of xenotransplantation with regards to risk of zoonotie or opportunistic infections. ..
- Model for the Prevention of Post-Transplant Skin CancerAnne Vanbuskirk; Fiscal Year: 2005..This model will provide the pre-clinical basis for new clinical trials in immunosuppressed patients, who are at extremely high risk for developing life-threatening, UV-induced SCC. ..
- Human/Pig Model of Hepatitis C Virus for New VaccinesWilliam Beschorner; Fiscal Year: 2005..A large animal immune compentent model of HCV will lead to a better understanding of the pathogenesis of hepatitis C virus and to more effective vaccines and immune therapy. ..
- CARDIAC GRAFTS--SKELETAL MYOBLASTSCHARLES MURRY; Fiscal Year: 2005....
- DONOR SPECIFIC IMMUNOSUPPRESSION TO TRACHEAL ALLOGRAFTSEric Genden; Fiscal Year: 2004..Specific Aim II will focus on alternative methods of inducing donor specific tolerance to tracheal allografts. Specific Aim III will focus on the behavior of the tracheal allograft and its affect upon the established state of tolerance. ..
- MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTSGALEN PIEPER; Fiscal Year: 2004..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
- CELLULAR AND MOLECULAR BASIS OF MELANOCYTE MORPHOGENESISCAROL ERICKSON; Fiscal Year: 2009..Understanding the fundamental mechanisms by which the neural crest cells are properly positioned will allow us to understand the underlying basis of these common birth defects. ..
- Determinants of Epithelial Survival in Airway AllograftsIsabel Neuringer; Fiscal Year: 2005....
- In vivo testing of the role of TGFb in PTLDAnne Vanbuskirk; Fiscal Year: 2003..The results from this pilot study will indicate whether TGFb is crucial to tumor formation in the SCID-Hu PBL mouse model. ..
- Dissecting Beta Adrenergic Signaling in Heart FailureMatthew Williams; Fiscal Year: 2003..abstract_text> ..
- Pre-Conditioning Pancreatic Islets for TransplantationGinny Bumgardner; Fiscal Year: 2006..The effect of oxygen pre-conditioning on islet viability and function in vivo will be determined using fluorescence microscopy and the marginal mass model of islet transplantation. ..
- Oxidative Stress Signaling in Graft Coronary DiseaseRobert Robbins; Fiscal Year: 2004..abstract_text> ..
- Composite Tissue TransplantationThomas Tung; Fiscal Year: 2006..The broad objective of this proposal is to improve the quality of reconstructive options and the quality of life for patients with devastating deformities. ..
- Innate Immune Responses in Obliterative BronchiolitisScott Palmer; Fiscal Year: 2006..He will apply these skills to direct future investigations of patient oriented research problems in pulmonary medicine...
- Tolerance to Carbohydrate Antigens in TransplantationDavid Cooper; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Thromboregulation to Prevent Thrombotic MicroangiopathyDavid Cooper; Fiscal Year: 2008..It is anticipated that these approaches will abrogate the development of TM and allow long-term survival of pig organs in baboons. ..
- CMV-Specific T-Cell Immunity in Lung Transplant RecipientsJohn McDyer; Fiscal Year: 2008..Understanding the immune response to CMV infection in susceptible lung transplant recipients may improve our treatment strategies and ultimately impact long-term outcomes in transplant recipients. [unreadable] [unreadable] [unreadable]..
- Regulation of Th1 responses by IL-2 receptor blockadeJohn McDyer; Fiscal Year: 2007..This K08 will provide the foundation for a research career dedicated to translational studies in immunology. ..
- Alcohol abuse exacerbates bronchiolitis obliteransPatrick Mitchell; Fiscal Year: 2007..This proposal has three overall goals: (1) to determine the effect of donor ethanol ingestion on OB; (2) to investigate the role of GMCSF; and (3) to investigate the role of TGFbeta1 in the pathogenesis of experimental-induced OB. ..
- Mesenchymal Progenitors of Intragraft FibroblastsGORDON WU; Fiscal Year: 2007..Completion of this research project will have defined the FP of IF and determined the migratory mechanisms by which FP home to allografts during chronic rejection. ..
- Manipulation of intracellular pH for treatment of NIDDMSubhadra Gunawardana; Fiscal Year: 2006....
- Antigen Presentation in CD4-mediated Cardiac RejectionTodd Grazia; Fiscal Year: 2003..endothelial cells). These chimeric mice can then serve as heart donors into immunodeficient recipients reconstituted with CD4 T-cells. Results of these studies will have significant implications for targeted therapy. ..
- Use of Gene Therapy to Induce Transplantation ToleranceMary Kearns Jonker; Fiscal Year: 2003..abstract_text> ..
- Mesenchymal Stem Cells in the Treatment of Lung FibrosisLuis Ortiz; Fiscal Year: 2008..3) To determine whether or not the systemic administration of MSCs can be used to ameliorate the fibroproliferative responses observed in the injured lung. ..