heterologous transplantation

Summary

Summary: Transplantation between animals of different species.

Top Publications

  1. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
  2. pmc Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    Sarah P Thayer
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 425:851-6. 2003
  3. ncbi Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents
    Matus Studeny
    Department of Blood and Marrow Transplantation, Section of Molecular Hematology and Therapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 448, Houston, TX 77030, USA
    J Natl Cancer Inst 96:1593-603. 2004
  4. pmc Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
  5. pmc Efficient tumour formation by single human melanoma cells
    Elsa Quintana
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 456:593-8. 2008
  6. ncbi Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion
    Dan Liu
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Res 67:3117-26. 2007
  7. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
  8. ncbi Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience
    Kenji Kuwaki
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, 13th Street, Boston, Massachusetts 02129, USA
    Nat Med 11:29-31. 2005
  9. pmc Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
    J I Johnson
    Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
    Br J Cancer 84:1424-31. 2001
  10. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004

Detail Information

Publications312 found, 100 shown here

  1. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
    ..Targeting DNA damage checkpoint response in cancer stem cells may overcome this radioresistance and provide a therapeutic model for malignant brain cancers...
  2. pmc Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    Sarah P Thayer
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 425:851-6. 2003
    ..These data suggest that this pathway may have an early and critical role in the genesis of this cancer, and that maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis...
  3. ncbi Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents
    Matus Studeny
    Department of Blood and Marrow Transplantation, Section of Molecular Hematology and Therapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 448, Houston, TX 77030, USA
    J Natl Cancer Inst 96:1593-603. 2004
    ..Mesenchymal stem cells (MSC) can be used to target delivery of agents to tumor cells. We tested whether MSC can deliver IFN-beta to tumors, reducing toxicity...
  4. pmc Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
    ..Thus, the NOD/SCID/IL2rgamma(null) newborn system might be an important experimental model to study the human hemato-lymphoid system...
  5. pmc Efficient tumour formation by single human melanoma cells
    Elsa Quintana
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 456:593-8. 2008
    ..Modifications to xenotransplantation assays can therefore dramatically increase the detectable frequency of tumorigenic cells, demonstrating that they are common in some human cancers...
  6. ncbi Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion
    Dan Liu
    Department of Physiology and Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Res 67:3117-26. 2007
    ..This exposure may increase cancer cell proliferation and result in promotion of preneoplastic cells...
  7. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
    ....
  8. ncbi Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience
    Kenji Kuwaki
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, 13th Street, Boston, Massachusetts 02129, USA
    Nat Med 11:29-31. 2005
    ..There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies...
  9. pmc Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
    J I Johnson
    Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
    Br J Cancer 84:1424-31. 2001
    ..0001). Structural parameters of the drugs analysed included compound molecular weight and hydrogen-bonding factors, both of which were found to be predictive of hollow fibre activity...
  10. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  11. ncbi The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
    Qihong Huang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Nat Cell Biol 10:202-10. 2008
    ..Taken together, our findings indicate that miRNAs are involved in tumour migration and invasion, and implicate miR-373 and miR-520c as metastasis-promoting miRNAs...
  12. ncbi PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    J Li
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Science 275:1943-7. 1997
    ..These homologies suggest that PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions...
  13. ncbi Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G-protein coupled formylpeptide receptor FPR
    X H Yao
    Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing, People s Republic of China
    J Pathol 215:369-76. 2008
    ..Our results indicate that FPR expressed by human GSCs may play an important role in glioma angiogenesis...
  14. pmc Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
    B Elenbaas
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 15:50-65. 2001
    ..Thus, these observations establish an experimental system for elucidating both the genetic and cell biological requirements for the development of breast cancer...
  15. ncbi Tumor growth need not be driven by rare cancer stem cells
    Priscilla N Kelly
    Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Science 317:337. 2007
    ..We suggest that the low frequency of tumor-sustaining cells observed in xenotransplantation studies may reflect the limited ability of human tumor cells to adapt to growth in a foreign (mouse) milieu...
  16. pmc Production of alpha 1,3-galactosyltransferase-deficient pigs
    Carol J Phelps
    PPL Therapeutics Inc, 1700 Kraft Drive, Blacksburg, VA 24060, USA
    Science 299:411-4. 2003
    ....
  17. ncbi Expression of CD133 on leukemia-initiating cells in childhood ALL
    Charlotte V Cox
    Bristol Institute for Transfusion Sciences, Bristol, United Kingdom
    Blood 113:3287-96. 2009
    ..These data suggest that leukemia-initiating cells in childhood B-ALL have a primitive CD133(+)/CD19(-) and CD38(-) phenotype...
  18. ncbi 3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography
    Henryk Barthel
    Cancer Research United Kingdom PET Oncology Group, Department of Cancer Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, London W12 0NN, United Kingdom
    Cancer Res 63:3791-8. 2003
    ..The decrease in [(18)F]FLT uptake after 5-FU was more pronounced than that of [(18)F]FDG. [(18)F]FLT is, therefore, a promising marker for monitoring antiproliferative drug activity in oncology that warrants additional testing...
  19. ncbi Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model
    Stephanie Alexander
    Department of Dermatology, Venerology, and Allergology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Histochem Cell Biol 130:1147-54. 2008
    ..This modified window model will be suited to address mechanisms of cancer invasion and metastasis, and related experimental therapy...
  20. ncbi Mammalian tumor xenografts induce neovascularization in zebrafish embryos
    Stefania Nicoli
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Cancer Res 67:2927-31. 2007
    ..These data show that the zebrafish/tumor xenograft model represents a novel tool for investigating the neovascularization process exploitable for drug discovery and gene targeting in tumor angiogenesis...
  21. pmc Clinically proven markers of metastasis predict metastatic spread of human melanoma cells engrafted in scid mice
    A Thies
    Zentrum für Experimentelle Medizin, Institut für Anatomie II Experimentelle Morphologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, Hamburg D 20246, Germany
    Br J Cancer 96:609-16. 2007
    ....
  22. ncbi Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers
    Chouhei Sakakura
    Surgery and Regenerative Medicine, Kyoto Prefectural University of Medicine, Japan
    Clin Cancer Res 11:6479-88. 2005
    ..Changes in metastatic potential were assessed in animal experiments using stable RUNX3 transfectants of gastric cancer cells. Finally, global expression changes were analyzed using a cDNA microarray...
  23. ncbi Porcine endogenous retroviruses and xenotransplantation
    C A Wilson
    Division of Cellular and Gene Therapies, Gene Transfer and Immunogenicity Branch, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Cell Mol Life Sci 65:3399-412. 2008
    ..However, in spite of the past 10 years of investigation, the actual risk for PERV infection, replication, and pathogenic outcome in human recipients of xenotransplantation products is still undefined. (Part of a multi-author review)...
  24. ncbi T-cell responses during pig-to-primate xenotransplantation
    Eduardo Davila
    Department of Pediatrics, Louisiana State University Health Science Center, Stanley S Scott Cancer Center, New Orleans, LA, USA
    Xenotransplantation 13:31-40. 2006
    ..To determine the potential role of T lymphocytes in Xenograft (Xg) rejection, we transplanted transgenic hCD46 porcine hearts heterotopically into baboon recipients...
  25. ncbi The relationship between bone metastasis from human breast cancer and integrin alpha(v)beta3 expression
    Shin Takayama
    Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Anticancer Res 25:79-83. 2005
    ..Integrin alpha(v)beta3 mediates the attachment of osteoclasts to bone matrix, and it is overexpressed in bone-residing breast cancer cells. We studied BM from breast cancer in relation to its Integrin alpha(v)beta3 expression...
  26. ncbi Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development
    L R Kelland
    Antisoma Research Laboratories, St Georges Hospital Medical School, Cranmer Terrace, London SW17 OQS, UK
    Eur J Cancer 40:827-36. 2004
    ..g. inhibitors of the metastatic process and anti-angiogenic strategies as the vasculature is of murine origin)...
  27. ncbi Development and evaluation of a novel decellularized vascular xenograft
    B S Conklin
    School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30322, USA
    Med Eng Phys 24:173-83. 2002
    ..This study provides a new strategy to develop a small-caliber vascular graft with excellent mechanical properties, antithrombogeneity, and tissue compatibility...
  28. ncbi Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 62:661-4. 2002
    ..Hypoxic cells could not be detected in these tumors. Our study suggests that interstitial hypertension may facilitate tumor cell intravasation and, hence, promote metastasis by mechanisms independent of tumor hypoxia...
  29. ncbi Transplants of human mesenchymal stem cells improve functional recovery after spinal cord injury in the rat
    Dasa Cizkova
    Institute of Neurobiology, Center of Excellence, SAS, Soltesovej 4, Kosice, 04001, Slovakia
    Cell Mol Neurobiol 26:1167-80. 2006
    ..In addition, low immunogenicity of hMSCs was confirmed by survival of donor cells without immunosuppressive treatment...
  30. pmc Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents
    C R Ireson
    1Endocrinology and Metabolic Medicine and Sterix Ltd, Faculty of Medicine, Imperial College, St Mary s Hospital, London W2 1NY, UK
    Br J Cancer 90:932-7. 2004
    ..The resistance to metabolism shown by 2-MeOE2bisMATE and its ability to inhibit tumour growth in vivo suggest that this compound should have considerable potential for development as a novel anticancer drug...
  31. ncbi Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis
    Laetitia Devy
    Dyax Corp, Cambridge, Massachusetts 02139, USA
    Cancer Res 69:1517-26. 2009
    ..The combination of potency, selectivity, and robust in vivo activity shows the potential of a selective MMP-14 inhibitor for the treatment of solid tumors...
  32. pmc Attenuation of phagocytosis of xenogeneic cells by manipulating CD47
    Hui Wang
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, MGH East, Bldg 149 5102, 13th St, Boston, MA 02129, USA
    Blood 109:836-42. 2007
    ....
  33. ncbi Prolonged survival of fetal pig islet xenografts in mice lacking the capacity for an indirect response
    Maria Koulmanda
    Islet Transplantation Research Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Xenotransplantation 11:525-30. 2004
    ....
  34. ncbi The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation
    Lisa M J Lee
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois 60614 3394, USA
    Dev Dyn 233:1560-70. 2005
    ..These results demonstrate the utility of the zebrafish embryonic model for the study of tumor cell plasticity and suggest that this experimental paradigm can be a powerful one in which to investigate tumor-microenvironment interactions...
  35. ncbi [18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates
    Roland Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, 81675 Munchen, Germany
    Bioconjug Chem 15:61-9. 2004
    ..2 GBq of [18F]flouride. Moreover, the fast excretion, the suitable metabolic stability and the low estimated radiation dose allow to evaluate this tracer in human studies...
  36. ncbi Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response
    Jann N Sarkaria
    Department of Radiation Oncology, Laboratory Medicine and Pathology, and Biostatistics, Mayo Clinic, Rochester, Minnesota, USA
    Clin Cancer Res 12:2264-71. 2006
    ..The intent of the current study was to address this relationship using several EGFR-amplified glioblastoma xenografts in an orthotopic athymic mouse model...
  37. ncbi Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke
    Franciska Erdo
    Department of Experimental Neurology, Max Planck Institute for Neurological Research, University of Cologne, Cologne, Germany
    J Cereb Blood Flow Metab 23:780-5. 2003
    ....
  38. ncbi Clonogenic assay with established human tumour xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery
    H H Fiebig
    Institute for Experimental Oncology, Oncotest GmbH, Am Flughafen 12 4, D 79108 Freiburg, Germany
    Eur J Cancer 40:802-20. 2004
    ..Thus, the tumour clonogenic assay has proven predictive value in the chemosensitivity testing of standard and experimental anticancer drugs...
  39. pmc Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment
    T Pearson
    Diabetes Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Clin Exp Immunol 154:270-84. 2008
    ..NOD-Rag1(null) IL2rgamma(null) mice will be an important new model for human lymphohaematopoietic cell engraftment studies that require radioresistant hosts...
  40. ncbi Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Radiat Biol 75:1377-93. 1999
    ..The purpose of the work reported here was (1) to determine the fraction of radiobiologically hypoxic cells in individual tumours and (2) to differentiate quantitatively between chronic and acute hypoxia...
  41. ncbi Alpha-Gal on bioprostheses: xenograft immune response in cardiac surgery
    K Z Konakci
    Medizinische Universität Wien, Vienna, Austria
    Eur J Clin Invest 35:17-23. 2005
    ..We sought to investigate whether a specific alpha-Gal immune response may play a role in this clinical scenario...
  42. ncbi Mesenchymal stem cells of cord blood origin are effective at preventing but not treating graft-versus-host disease
    V Tisato
    Stem Cell Biology Section, Kennedy Institute of Rheumatology, Imperial College, London, UK
    Leukemia 21:1992-9. 2007
    ..No therapeutic effect was obtained if UCB-MSC were administered at onset of GVHD. This work supports the clinical use of MSC in stem cell transplantation as a prophylaxis rather than treatment of GVHD...
  43. ncbi Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials
    Dongming Hou
    Indiana University School of Medicine, Indianapolis, IN, USA
    Circulation 112:I150-6. 2005
    ..We evaluated the short-term fate of peripheral blood mononuclear cells (PBMNCs) after intramyocardial (IM), intracoronary (IC), and interstitial retrograde coronary venous (IRV) delivery in an ischemic swine model...
  44. pmc Identification of cells initiating human melanomas
    Tobias Schatton
    Transplantation Research Center, Children s Hospital Boston and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 451:345-9. 2008
    ..Identification of tumour-initiating cells with enhanced abundance in more advanced disease but susceptibility to specific targeting through a defining chemoresistance determinant has important implications for cancer therapy...
  45. ncbi Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
    Ping Lan
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Blood 108:487-92. 2006
    ..Thus, the humanized NOD/SCID mice described in this paper provide a powerful model system to study human immune function...
  46. pmc Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    Toru Kondo
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 101:781-6. 2004
    ..We propose that many cancer cell lines contain a minor subpopulation of stem cells that is enriched in an SP, can be maintained indefinitely in culture, and is crucial for their malignancy...
  47. ncbi Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871
    Bruce D Cohen
    Pfizer Global Research and Development, Inc, Eastern Point Road, Groton, CT 06340, USA
    Clin Cancer Res 11:2063-73. 2005
    ..We generated and characterized a human monoclonal antibody that targeted the IGF receptor...
  48. ncbi alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months
    Yau Lin Tseng
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Transplantation 80:1493-500. 2005
    ..The recent generation of alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs has allowed investigation of the survival of GalT-KO pig organs in nonhuman primates...
  49. ncbi Transcriptional gene expression profiling of small cell lung cancer cells
    Nina Pedersen
    Department of Radiation Biology, The Finsen Centre, National University Hospital, Copenhagen DK 2100, Denmark
    Cancer Res 63:1943-53. 2003
    ..This analysis demonstrates the value of using cell lines and xenografts for expression profiling, when a limited quantity of tumor material is available...
  50. ncbi Higher susceptibility of NOG mice to xenotransplanted tumors
    Kazuhiko Machida
    Testing Services Department, Central Institute for Experimental Animals, Kanagawa 216 0001, Japan
    J Toxicol Sci 34:123-7. 2009
    ..These data suggest that NOG mice may be the best choice as a suitable strain for testing tumorigenicity...
  51. ncbi Local endostatin treatment of gliomas administered by microencapsulated producer cells
    T A Read
    Department of Anatomy and Cell Biology, University of Bergen, Norway
    Nat Biotechnol 19:29-34. 2001
    ..The present work may thus provide the basis for new therapeutic approaches toward brain tumors...
  52. ncbi Cardiac xenotransplantation: recent preclinical progress with 3-month median survival
    Christopher G A McGregor
    Division of Cardiovascular Surgery, Department of Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    J Thorac Cardiovasc Surg 130:844-51. 2005
    ..Overcoming the immune barrier to successful cardiac xenotransplantation is most appropriately first explored with the non-life-supporting heterotopic model...
  53. ncbi CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL
    Y Kong
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Leukemia 22:1207-13. 2008
    ..Recapitulation of patient B-ALL in NOD/SCID/IL2rgamma(null) recipients provides a powerful tool for directly studying leukemogenesis and for developing therapeutic strategies...
  54. ncbi Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains
    Alice Agliano
    Division of Hematology Oncology, Department of Medicine, European Institute of Oncology, Milan, Italy
    Int J Cancer 123:2222-7. 2008
    ..These models will be instrumental to studies on leukemia-initiating stem cells, leukemia biology, preclinical treatment studies, and to obtain patient-specific preclinical models to design and investigate patient-tailored therapies...
  55. pmc Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    Matthias Lauth
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum Research Park, Hälsovägen 7, SE 141 57 Huddinge, Sweden
    Proc Natl Acad Sci U S A 104:8455-60. 2007
    ....
  56. ncbi Head and neck squamous cell carcinoma cell lines: established models and rationale for selection
    Charles J Lin
    Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Head Neck 29:163-88. 2007
    ..An easily accessible guide that organizes important characteristics of HNSCC cell lines would be valuable for the selection of appropriate HNSCC cell lines for in vitro or in vivo studies...
  57. ncbi Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
    Dmitri B Kirpotin
    Hermes Biosciences Inc, South San Francisco, CA, USA
    Cancer Res 66:6732-40. 2006
    ..Immunoliposomes capable of selective internalization in cancer cells in vivo may provide new opportunities for drug delivery...
  58. ncbi Combined in vivo effect of A12, a type 1 insulin-like growth factor receptor antibody, and docetaxel against prostate cancer tumors
    Jennifer D Wu
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin Cancer Res 12:6153-60. 2006
    ..Based on these data, we investigated the combined in vivo effect of A12 and docetaxel on human androgen-independent and osseous prostate tumor growth...
  59. ncbi Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans
    J Mordenti
    Experimental Therapeutics, Genentech, Inc, South San Francisco, California 94080, USA
    Toxicol Pathol 27:14-21. 1999
    ....
  60. pmc Stromelysin-3 expression promotes tumor take in nude mice
    A C Noël
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, IGBMC, Universite Louis Pasteur, Strasbourg, France
    J Clin Invest 97:1924-30. 1996
    ..These findings represent the first experimental evidence showing that ST3 can modulate cancer progression...
  61. pmc A robust xenotransplantation model for acute myeloid leukemia
    P V Sanchez
    Department of Medicine, Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA
    Leukemia 23:2109-17. 2009
    ..We conclude that the NSG xenotransplantation model is a robust model for human AML cell engraftment, which will allow better characterization of AML biology and testing of new therapies...
  62. ncbi Immunosuppression by retroviruses: implications for xenotransplantation
    J Denner
    Paul Ehrlich Institut, Langen, Germany
    Ann N Y Acad Sci 862:75-86. 1998
    ....
  63. pmc Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo
    L Houcine Ouafik
    Laboratoires de CancérologieExpérimentale and Transfert d OncologieBiologique, Faculté de MédecineSecteur Nord, IFR Jean Roche, Marseille, France
    Am J Pathol 160:1279-92. 2002
    ..These findings support that AM may function as a potent autocrine/paracrine growth factor for human glioblastomas and demonstrate that inhibition of the action of AM (produced by tumor cells) may suppress tumor growth in vivo...
  64. ncbi Improvement of pharmacokinetics of radioiodinated Tyr(3)-octreotide by conjugation with carbohydrates
    Margret Schottelius
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munchen, Germany
    Bioconjug Chem 13:1021-30. 2002
    ..8 mg TOC/kg and gamma-camera imaging. Glycosylation proved to be a powerful tool for the development of high affinity sst ligands with excellent excretion profiles and improved tumor accumulation...
  65. ncbi In vivo angiogenic activity of neuroblastoma correlates with MYCN oncogene overexpression
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari, Policlinico, Bari, Italy
    Int J Cancer 102:351-4. 2002
    ....
  66. pmc Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2
    Andrea D Basso
    Program in Pharmacology, Weill Graduate School of Medical Sciences, Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Oncogene 21:1159-66. 2002
    ..Thus, pharmacological inhibition of Akt activation is achievable with ansamycins and may be useful for the treatment of HER2 driven tumors...
  67. ncbi HOXB7: a key factor for tumor-associated angiogenic switch
    A Care
    Department of Hematology and Oncology, Istituto Superiore di Sanita, 00161 Rome
    Cancer Res 61:6532-9. 2001
    ....
  68. ncbi Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/gammac(null) (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells
    Takuya Matsumura
    Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    Exp Hematol 31:789-97. 2003
    ..In this study, we investigated whether CD5+ cells differentiate from adult hematopoietic stem cells (HSCs) as well as fetal ones in immunodeficient mice...
  69. ncbi Production of angiogenic factors by human glioblastoma cells following activation of the G-protein coupled formylpeptide receptor FPR
    Xiao hong Yao
    Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China
    J Neurooncol 86:47-53. 2008
    ..These results suggest that FPR plays an important role in the angiogenesis of human malignant gliomas through increasing the production of angiogenic factors by FPR positive tumor cells...
  70. ncbi Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice
    C M Ahmed
    University of Florida, Department of Microbiology and Cell Science, Gainesville, FL 32611 0700, USA
    J Interferon Cytokine Res 21:399-408. 2001
    ..As the AFP promoter is activated in many HCC cells but is silent in normal cells, these constructs may be useful in restricting IFN effects to the tumor cells while reducing toxicity to the neighboring tissues...
  71. ncbi The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer
    S A Ahmad
    Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    Cancer Res 61:1255-9. 2001
    ..These data suggest that imbalances between Ang-1 and -2 that result in a net gain of Ang-2 activity lead to enhanced tumor angiogenesis and growth...
  72. ncbi Formylpeptide receptor FPR and the rapid growth of malignant human gliomas
    Ye Zhou
    Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
    J Natl Cancer Inst 97:823-35. 2005
    ..We previously showed that selected human glioma cell lines also express functional FPR. We therefore investigated the relationship between FPR expression and the biologic behavior of glioma cells...
  73. ncbi Changes in subchondral bone in cartilage resurfacing--an experimental study in sheep using different types of osteochondral grafts
    B von Rechenberg
    Musculoskeletal Research Unit, Department of Equine Sciences, University of Zurich, Winterhurerstrasse 260, 8057, Zurich, Switzerland
    Osteoarthritis Cartilage 11:265-77. 2003
    ..Photooxidation was expected to improve mechanical stability of the osteochondral grafts through an improved linkage of the collagen fibers within the bone matrix...
  74. pmc GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression
    Yi Cai
    Department of Pathology, Baylor College of Medicine, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Cancer Res 69:819-27. 2009
    ..Thus, increased GGAP2 expression, which is present in three quarters of human prostate cancers, can activate two critical pathways that have been linked to prostate cancer initiation and progression...
  75. ncbi Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts
    Larry R Tait
    Breast Program of the Barbara Ann Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Int J Cancer 120:2127-34. 2007
    ..Although the phenotype of the epithelial cells may be dependent upon the stroma, the malignant epithelium induces the development of the stroma necessary for progression to the invasive stage. (c) 2007 Wiley-Liss, Inc...
  76. ncbi Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Cancer Res 60:4932-8. 2000
    ..Our observations suggest that efficient antiangiogenic treatment of melanoma may require identification and blocking of common functional features of several angiogenic factors...
  77. ncbi Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation
    Mong Hsun Tsai
    Radiation Biology, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Cancer Res 67:3845-52. 2007
    ....
  78. ncbi Achieving permanent survival of islet xenografts by independent manipulation of direct and indirect T-cell responses
    Vincenzo Mirenda
    Department of Immunology, Division of Medicine, Imperial College London, UK
    Diabetes 54:1048-55. 2005
    ..These results suggest that a similar approach could have clinical utility in porcine islet xenotransplantation...
  79. pmc Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern
    E K Rofstad
    Department of Biophysics, Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 70:804-12. 1994
    ..The four orthotopic human melanoma xenograft model systems show great promise for future studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern...
  80. ncbi T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts
    Shounan Yi
    National Pancreas Transplant Unit, University of Sydney at Westmead Hospital, Westmead, New South Wales, Australia
    J Immunol 170:2750-8. 2003
    ..This suggests that in xenograft rejection, there are macrophage-specific recognition and targeting signals that are independent of those received by T cells...
  81. pmc A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes
    Inigo Angulo-Barturen
    Diseases of the Developing World, Infectious Diseases Centre for Excellence in Drug Discovery, GlaxoSmithKline, Tres Cantos, Madrid, Spain
    PLoS ONE 3:e2252. 2008
    ..Thus, our results demonstrate that P. falciparum contains clones able to grow reproducibly in mice engrafted with human erythrocytes without the use of myeloablative methods...
  82. ncbi The use of photooxidized, mushroom-structured osteochondral grafts for cartilage resurfacing--a comparison to photooxidized cylindrical grafts in an experimental study in sheep
    B von Rechenberg
    Musculoskeletal Research Unit, Equine Hospital, Faculty of Veterinary Medicine, University of Zurich, Zurich, Switzerland
    Osteoarthritis Cartilage 12:201-16. 2004
    ..This article addresses the problem of structural design with osteochondral grafts used for cartilage resurfacing...
  83. pmc Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model
    Gil Hecht
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 106:8659-64. 2009
    ..Its long-term proliferative capacity, its revascularization by host endothelium, and its reduced immunogenicity, strongly suggest that this approach could offer an attractive replacement therapy for diabetes...
  84. ncbi Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia
    Dengli Hong
    Medical Research Council MRC Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Science 319:336-9. 2008
    ..Analysis of TEL-AML1-transduced cord blood cells suggests that TEL-AML1 functions as a first-hit mutation by endowing this preleukemic cell with altered self-renewal and survival properties...
  85. ncbi Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide
    Xiaoyuan Chen
    University of Southern California, Los Angeles, USA
    Mol Imaging 3:96-104. 2004
    ..5 +/- 0.8. The synergistic effect of polyvalency and improved pharmacokinetics may be responsible for the superior imaging characteristics of [18F]FB-E[c(RGDyK)]2...
  86. ncbi Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
    Kazuhiko Yamada
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Nat Med 11:32-4. 2005
    ..We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels...
  87. ncbi Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells
    Joby L McKenzie
    Department of Molecular and Medical Genetics, University of Toronto, ON, Canada
    Blood 106:1259-61. 2005
    ..These modifications to the SRC assay provide improved detection of human stem cells and demonstrate that CD122+ cells provide barriers to stem cell engraftment, a finding with potential clinical relevance...
  88. pmc Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model
    Louise S Villadsen
    Department of Dermatology, Gentofte University Hospital, Copenhagen, Denmark
    J Clin Invest 112:1571-80. 2003
    ..These results obtained with this IL-15-specific mAb support an important role for IL-15 in the pathogenesis of psoriasis...
  89. ncbi Antitumor activity of poly(L-glutamic acid)-paclitaxel on syngeneic and xenografted tumors
    C Li
    Division of Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Clin Cancer Res 5:891-7. 1999
    ..Future studies to elucidate the mechanism of action of PG-TXL and to assess its clinical applications are warranted...
  90. ncbi Side population cells isolated from mesenchymal neoplasms have tumor initiating potential
    Colleen Wu
    Program in Developmental and Stem Cell Biology, Toronto Medical Discovery Tower, Hospital for Sick Children, Toronto, ON, Canada
    Cancer Res 67:8216-22. 2007
    ..In addition, our data suggest that the proportion of SP cells could be used as a prognostic factor and that therapeutically targeting this subpopulation of cells could be used to improve patient outcome...
  91. ncbi Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor
    K Mishima
    Ludwig Institute for Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, California 92093-0660, USA
    Cancer Res 61:5349-54. 2001
    ..These data provide preclinical evidence that mAb 806 treatment may be a useful biotherapeutic agent for those aggressive gliomas that express DeltaEGFR...
  92. ncbi Migration pathways of human glioblastoma cells xenografted into the immunosuppressed rat brain
    J S Guillamo
    , IM3, , , France
    J Neurooncol 52:205-15. 2001
    ..The present results support the existence of host/tumor cells interactions with specific characteristics for each type of invasion...
  93. ncbi Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation
    A Fornoni
    Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10th Avenue, Miami, FL 33136, USA
    Diabetologia 51:298-308. 2008
    ..The objective of this study was to investigate if JNK inhibition with a cell-permeable TAT peptide inhibitor (L-JNKI) protects functional beta cell mass in human islets and affects AKT and its substrates in islet cells...
  94. ncbi Human adaptive immune system Rag2-/-gamma(c)-/- mice
    Laurie Chicha
    Department of Medicine II, Eberhard Karls University Medical School, Otfried Mueller Str 10, 72076 Tubingen, Germany
    Ann N Y Acad Sci 1044:236-43. 2005
    ....
  95. ncbi Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts
    Tsunehiro Kobayashi
    Department of Surgery, Dentistry Pharmacy Centre, Surgical Medical Research Institute, University of Alberta, Edmonton, AB, Canada
    Xenotransplantation 13:547-59. 2006
    ..Therefore, in this study we characterized the immune cells and molecules that are involved in this process by examining the microencapsulated NPI xenografts at various time points post-transplantation in B6 mice...
  96. ncbi Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    T Karpanen
    Molecular/Cancer Biology Laboratory, Haartman Institute and Ludwig Institute for Cancer Research, University of Helsinki, Finland
    Cancer Res 61:1786-90. 2001
    ..Our data suggest that VEGF-C facilitates tumor metastasis via the lymphatic vessels and that tumor spread can be inhibited by blocking the interaction between VEGF-C and its receptor...
  97. ncbi Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors
    Solmaz Sobhanifar
    British Columbia Cancer Research Center, Vancouver, British Columbia, Canada
    Cancer Res 65:7259-66. 2005
    ..These results have implications for the use of HIF-1alpha as an indicator of tumor hypoxia and aggressiveness as well as development of hypoxia-directed antitumor therapies based on the expression of HIF-1alpha...
  98. ncbi A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts
    Liliane Goetsch
    Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, 74160, St Julien en Genevois, France
    Int J Cancer 113:316-28. 2005
    ....
  99. ncbi Experimental model and immunohistochemical analyses of U87 human glioblastoma cell xenografts in immunosuppressed rat brains
    Tadej Strojnik
    Department of Neurosurgery, Maribor Teaching Hospital, Ljubljanska 5, SI 2000 Maribor, Slovenia
    Anticancer Res 26:2887-900. 2006
    ..To study the neuropathology and selected tumour markers of malignant gliomas, an animal glioma model was developed using the implantation of human glioblastoma clone U87 into rat brains...
  100. ncbi Protein disulfide isomerase expression is related to the invasive properties of malignant glioma
    Dorota Goplen
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Cancer Res 66:9895-902. 2006
    ..In conclusion, using a global proteomics approach, PDI was identified to play an important role in glioma cell invasion, and its action was effectively inhibited by bacitracin...
  101. ncbi Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
    L D Shultz
    Jackson Laboratory, Bar Harbor, ME 04609
    J Immunol 154:180-91. 1995
    ..B-17/Sz-scid/scid animals. The multiple defects in innate and adaptive immunity unique to the NOD/LtSz-scid/scid mouse provide an excellent in vivo environment for reconstitution with human hematopoietic cells...

Research Grants71

  1. Design and Evaluation of Ultrasound Stimulation Aided Bioreactor Configurations
    Anu Subramanian; Fiscal Year: 2010
    ..Current interventions that include autologous or heterologous transplantation, articular resurfacing, are of limited efficacy, and in the long term, untreated lesions may result in ..
  2. CORNEAL ENDOTHELIA TRANSPLANT: CLINICAL IMPLICATION
    DENIS GOSPODAROWICZ; Fiscal Year: 1980
    ..an experimental animal, we will do similar studies, if the cat and rabbit studies have shown that such heterologous transplantation is viable...
  3. BREAST CANCER
    THOMAS PRETLOW; Fiscal Year: 1980
    ..The tumorigenicity of the purified cells will be tested by heterologous transplantation. After the period of support requested, we expect that new proposals will be submitted for the support ..
  4. Thromboregulation to Prevent Thrombotic Microangiopathy
    David Cooper; Fiscal Year: 2008
    ..It is anticipated that these approaches will abrogate the development of TM and allow long-term survival of pig organs in baboons. ..
  5. Tolerance to Carbohydrate Antigens in Transplantation
    David Cooper; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. Transgenic Goats Produced by Germ Cell Transplantation
    Ina Dobrinski; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  7. IDENTIFICATION OF STEM CELL MARKERS IN MAMMALIAN TESTES
    Ina Dobrinski; Fiscal Year: 2002
    ..abstract_text> ..
  8. ROLES OF NITRIC OXIDE AND OXYGEN IN OCULAR MELANOMA
    RODNEY BRAUN; Fiscal Year: 2002
    ....
  9. INCREASE/gp120 IMMUNOGENICITY/LINKED ALPHA-GAL EPITOPES
    Uri Galili; Fiscal Year: 2005
    ..We will then also collaborate with a group studying immune responses in monkeys to determine the efficacy of this vaccine in a primate model. ..
  10. Mixed Chimerism in Haploidentical Non-human Primates
    Bernhard Hering; Fiscal Year: 2006
    ..abstract_text> ..
  11. TOLERANCE TO ISLET ALLOGRAFTS IN TYPE I DIABETES
    Bernhard Hering; Fiscal Year: 2005
    ....
  12. Ultrasound Monitoring of Rat Metastatic Uveal Melanoma
    RODNEY BRAUN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. CTS-IPITA-IXA 2007 Joint Conference
    Bernhard Hering; Fiscal Year: 2007
    ..abstract_text> ..
  14. CD40L IN ALLOGRAFT TOLERANCE AND VIRAL IMMUNITY
    Richard Pierson; Fiscal Year: 2001
    ..Finally, this study will investigate the potential of CD40L inhibition to induce prolonged acceptance of a transplanted organ, and may contribute to development of clinically relevant approaches to the induction of tolerance. ..
  15. Advancing Islet Transplants for Type 1 Diabetes Care
    Bernhard Hering; Fiscal Year: 2008
    ..This study will also provide a rational basis for treatment recommendations for type 1 diabetic patients with early microvascular lesions. ..
  16. Human Pancreatic Islet Cell Resources
    Bernhard Hering; Fiscal Year: 2008
    ..abstract_text> ..
  17. PREVENTING ANTI-GAL PRODUCTION AGAINST XENOGRAFTS
    Uri Galili; Fiscal Year: 2003
    ..Success in these studies will help in planning effective treatments for preventing anti-Gal response in primate xenografts recipients. | ..
  18. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  19. Retinoids, RAMBAs, and Histone Deacetylase Inhibitors
    Vincent Njar; Fiscal Year: 2006
    ..The following specific aims that are proposed should enable us obtain substantial data that may support our hypothesis. ..
  20. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
  21. Novel Cationic 99mTc Complexes for Heart Imaging
    Shuang Liu; Fiscal Year: 2006
    ..Successful development of new 99mTc perfusion imaging agents will have a profound impact on diagnostic evaluation, risk stratification, and therapeutic decision-making in patients with CAD. ..
  22. Novel Ternary Ligand 99m Tc-Nitrido Complexes as Heart Imaging Agents
    Shuang Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2006
    ..Once SERT binding is determined in depressed patients, we will be able to assess the relationship of SERT binding and treatment response to SSRIs. ..
  24. Imaging Alpha (v)beta(3) Integrin Expression
    Xiaoyuan Chen; Fiscal Year: 2006
    ..abstract_text> ..
  25. Development of Novel Fluorinated Amino Acids
    Mark Goodman; Fiscal Year: 2004
    ..abstract_text> ..
  26. Experience modulates brain plasticity in adult primates
    Yevgenia Kozorovitskiy; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. Humoral And Cellular Tolerization Approaches Against Autoimmunity
    Massimo Trucco; Fiscal Year: 2007
    ..abstract_text> ..
  28. Mechanisms of estrogen action on bone marrow-derived stem stromal cells
    Charlotte Kuperwasser; Fiscal Year: 2011
    ..abstract_text> ..
  29. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  30. Color-coded transposor-mediated rat mutagenesis
    Richard Behringer; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. Functional and Tissue Specific Effects of VHL Mutations
    WENDY RATHMELL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Hormonal Therapy to Increase Islet Recovery/Engraftment From Multiorgan Donors
    Juan Contreras; Fiscal Year: 2008
    ..abstract_text> ..
  33. Camptothecin Analogs for Cancer Therapy
    LEE MORGAN; Fiscal Year: 2007
    ..Prior to the latter, DEKK-TEC proposes screening the analogs in a wide spectrum of tumor models to insure the best cancer applications for the products. [unreadable] [unreadable] [unreadable]..
  34. Human Copper Transporter 1 as Reporter Gene for Imaging
    Fangyu Peng; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  35. CROSS TRAINING OF UNDERGRADUATE STUDENTS
    Thomas Andersen; Fiscal Year: 2008
    ..The application details the successful outcomes of this program during the preceding funding period. [unreadable] [unreadable]..
  36. Reconstruction of nigrostriatal pathway by photopolymerized neurotrophin...
    Kimberly Bjugstad; Fiscal Year: 2008
    ..While we are using an animal model of PD to test this hypothesis, if successful, it could have implications for other neurodegenerative disorders, including Huntington's Disease or stroke. [unreadable] [unreadable] [unreadable]..
  37. Expression of Proapoptotic Genes for Cancer Therapy
    Bingliang Fang; Fiscal Year: 2006
    ..Success of the proposed studies will lead to new therapeutics for refractory metastatic disease. It will also provide insight into mechanisms of resistance to apoptosis induction in cancer cells. ..
  38. Effects of brain-death on islet recovery and functional*
    John Thompson; Fiscal Year: 2006
    ..Overall, these studies will bring novel information about human islet biology and will provide c potential therapeutic strategy to enhance the therapeutic efficacy of PIT as a cure for diabetes. ..
  39. Induction of Apoptosis in Synovial Fibroblasts
    Haidi Zhang; Fiscal Year: 2003
    ..at an early stage of arthritis by intra-articular administration of an apoptosis inducer, such as FasL, using a suitable vector system, which may replace the treatment of synovectomy for some arthritis patients. ..
  40. INVESTIGATING THE MECHANISMS OF PRB TUMOR SUPPRESSION
    Arnab Chakravarti; Fiscal Year: 2003
    ..Specific Aim number 3: To determine whether the deregulation of E2F dependent transcription is correlated with the tumorigenic potential of RB -/- cells in-vivo. ..
  41. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  42. DONOR-DRIVEN REGULATION IN HUMAN ALLOGRAFT ACCEPTANCE
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to develop a working model of how donor-derived leukocytes and the antigens they release contribute to a tonic equilibrium between host T regulator and effector cells in human allograft acceptance. ..
  43. Improved Detection of Cancer Using Bi Specific Antibody
    ROBERT SHARKEY; Fiscal Year: 2003
    ....
  44. KIDNEY TRANSPLANTATION & NON-INHERITED MATERNAL ANTIGENS
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to establish the basis for a rational approach to HLA-matching and selective NIMA mismatching to achieve the goal of clinical kidney transplantation tolerance. ..
  45. NEW SYNTHESIS OF BIOCHEMICALS WITH HOMOGENEOUS CATALYSTS
    Iwao Ojima; Fiscal Year: 2003
    ..In this project, we plan to develop new synthetic routes to a variety of enantiopure heterocyclic and carbocyclic compounds of medicinal interest featuring diastereoselective or enantioselective catalytic processes as the key steps. ..
  46. Rhenium-188 therapy of NIS-expressing breast tumors
    Ekaterina Dadachova; Fiscal Year: 2003
    ..The long-term goal of this research is to contribute to the development of a novel cost-effective radionuclide therapy for treatment of breast cancer and, possibly, for other NIS-expressing cancers such as thyroid cancer. ..
  47. CMMI Human Subject Research Enhancement Program
    David Goldenberg; Fiscal Year: 2002
    ..3.) Provide travel expenses and educational materials for IRB members, investigators, and Regulatory Affairs Office personnel to attend meetings for educational enhancement. ..
  48. COMPATIBILITY OF SWINE STEM CELLS AND HUMAN STROMA
    Megan Sykes; Fiscal Year: 2002
    ....
  49. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  50. AIDS LYMPHOMA USING ANTISENSE TO EBV GENES
    Jill Lacy; Fiscal Year: 2001
    ....
  51. RADIOIMMUNOTHERAPY OF B CELL LYMPHOMA WITH ANTI CD74
    M Mattes; Fiscal Year: 2002
    ..This study may lead to the development of more effective radio-conjugates for the therapy of cancer and other diseases. Also, it will provide basic information about the toxic effects of intracellular (really lysosomal) radionuclides. ..
  52. Akt Inhibitors to Treat Ewing's Sarcoma
    Jeffrey Toretsky; Fiscal Year: 2005
    ..Our findings from this Phase I Sun will hopefully lead to a key compound that can be further developed in a Phase II STTR ultimately leading to clinical trials in patients with ESFT. ..
  53. PRE-CLINICAL COMBINATION CHEMO- AND RADIOANTIBODY THERAP
    Rhona Stein; Fiscal Year: 2005
    ..2) Therapy-induced changes in marker expression post therapy can be identified clinically in small samples of circulating tumor cells. ..
  54. FLT PET imaging for evaluating molecular therapeutics
    Jann Sarkaria; Fiscal Year: 2005
    ..abstract_text> ..
  55. Crosslinkable Hydrogels for Tympanic Membrane Repair
    Glenn Prestwich; Fiscal Year: 2004
    ..Third, we will evaluate the biocompability and otocompability of each gel in vivo by evaluating recovery of auditory function and middle ear histology. ..
  56. LIVER TRANSPLANTATION: THE ROLE OF DENDRITIC CELLS
    Angus Thomson; Fiscal Year: 2005
    ..The results will provide new insight into how liver dendritic cells can modulate survival of alloreactive T cells, and determine the potential of donor dendritic cells to delete allospecific T cells to facilitate transplant tolerance. ..
  57. Cord Blood Cells in ALS: Replacement of Protection?
    Svitlana Garbuzova Davis; Fiscal Year: 2004
    ..The results of this study may provide the basis for developing a novel, non-invasive therapy, easily accessed by ALS patients. ..
  58. 9/10TH Conf./Cancer Therapy/Antibody/Immunoconjugates
    David Goldenberg; Fiscal Year: 2004
    ..The conference chairman, Dr. Goldenberg, has secured two outstanding scientists as co-chairmen, Drs. Ralph Reisfeld (Scripps) and Edward Sausville (NCI). ..
  59. Fibroblast Activation Protein-alpha Activated Anti-Stromal Prodrug Therpay for Ca
    Samuel R Denmeade; Fiscal Year: 2010
    ..e. "stroma") within cancers rather than the cancer cells themselves can be effective therapy. The FAP- activated prodrug, therefore, could represent a new targeted therapy for a variety of human cancers. ..
  60. Molecular Analysis of Scarless Fetal Wound Healing
    Sandeep Kathju; Fiscal Year: 2007
    ..With these complementary approaches we hope to thereby arrive at a broad understanding of the gene patterns controlling both fetal and adult wound healing, and identify gene products/pathways critical to both. ..
  61. UNIQUE TISSUE AND TUMOR PROCESSING FACILITY
    Adi Gazdar; Fiscal Year: 2003
    ..A charge back fee system will recover some of the costs and will be used for future expansion of the Facility, which is anticipated to become self sustaining after five years. ..
  62. FcRlll Blockade as a Treatment for Autoimmune Disease
    Leslie Johnson; Fiscal Year: 2004
    ..the studies outlined in this application will provide the basis for expanded production, characterization and further safety and efficacy studies of this molecule in small animals and primates, ultimately leading to human clinical trials ..
  63. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..
  64. Development of Soluble FcR-Ig Fusion Proteins
    Leslie Johnson; Fiscal Year: 2004
    ..We believe that an FcR blockade would also be potentially useful in treating autoimmune hemolytic anemia, lupus, rheumatoid arthritis, Guillain-Barre syndrome and stiff man's syndrome. ..
  65. LIGHT DURING DARKNESS AND BREAST CANCER PROGRESSION
    David Blask; Fiscal Year: 2004
    ....
  66. PHYTOMELATONIN AND CANCER PREVENTION
    David Blask; Fiscal Year: 2004
    ....
  67. HYPOXIA AND GENE REPRESSION
    Amato Giaccia; Fiscal Year: 2009
    ..We will test these hypotheses through a combination of genetic and biochemical approaches in cell lines and in mice. ..