stem cell transplantation

Summary

Summary: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.

Top Publications

  1. ncbi Induced pluripotent stem cell lines derived from human somatic cells
    Junying Yu
    Genome Center of Wisconsin, Madison, WI 53706 1580, USA
    Science 318:1917-20. 2007
  2. ncbi Embryonic stem cell lines derived from human blastocysts
    J A Thomson
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Science 282:1145-7. 1998
  3. ncbi Mammalian neural stem cells
    F H Gage
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 287:1433-8. 2000
  4. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
  5. ncbi Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
  6. ncbi Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction
    Shao Liang Chen
    Division of Cardiology, Nanjing First Hospital, Nanjing University, Nanjing, Jiangsu Province, China
    Am J Cardiol 94:92-5. 2004
  7. ncbi Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
    Kristina Allers
    Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin, Charite University Medicine Berlin, Berlin, Germany
    Blood 117:2791-9. 2011
  8. ncbi Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
    Jalees Rehman
    Krannert Institute of Cardiology, Indiana Center for Vascular Biology and Medicine, Indianapolis, Ind 46202, USA
    Circulation 109:1292-8. 2004
  9. pmc Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    Luis A Ortiz
    Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:8407-11. 2003
  10. pmc Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
    Roberto Bolli
    Divisions of Cardiovascular Medicine, University of Louisville, Louisville, KY 40202, USA
    Lancet 378:1847-57. 2011

Detail Information

Publications336 found, 100 shown here

  1. ncbi Induced pluripotent stem cell lines derived from human somatic cells
    Junying Yu
    Genome Center of Wisconsin, Madison, WI 53706 1580, USA
    Science 318:1917-20. 2007
    ....
  2. ncbi Embryonic stem cell lines derived from human blastocysts
    J A Thomson
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Science 282:1145-7. 1998
    ..These cell lines should be useful in human developmental biology, drug discovery, and transplantation medicine...
  3. ncbi Mammalian neural stem cells
    F H Gage
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 287:1433-8. 2000
    ..Before the full potential of neural stem cells can be realized, we need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells...
  4. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
    ..As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases...
  5. ncbi Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
    ..Our data establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs...
  6. ncbi Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction
    Shao Liang Chen
    Division of Cardiology, Nanjing First Hospital, Nanjing University, Nanjing, Jiangsu Province, China
    Am J Cardiol 94:92-5. 2004
    ..Several imagining techniques demonstrated that bone marrow mesenchymal stem cells significantly improved left ventricular function...
  7. ncbi Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
    Kristina Allers
    Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin, Charite University Medicine Berlin, Berlin, Germany
    Blood 117:2791-9. 2011
    ..of CD4(+) T cells at the systemic level as well as in the gut mucosal immune system after CCR5Δ32/Δ32 stem cell transplantation, while the patient remains without any sign of HIV infection...
  8. ncbi Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
    Jalees Rehman
    Krannert Institute of Cardiology, Indiana Center for Vascular Biology and Medicine, Indianapolis, Ind 46202, USA
    Circulation 109:1292-8. 2004
    ..The beneficial effects of delivered cells appear to be related to their pluripotency and ability to secrete growth factors. We examined nonadipocyte stromal cells from human subcutaneous fat as a novel source of therapeutic cells...
  9. pmc Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    Luis A Ortiz
    Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:8407-11. 2003
    ..Collectively, these studies demonstrate that murine MSCs home to lung in response to injury, adopt an epithelium-like phenotype, and reduce inflammation and collagen deposition in lung tissue of mice challenged with BLM...
  10. pmc Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
    Roberto Bolli
    Divisions of Cardiovascular Medicine, University of Louisville, Louisville, KY 40202, USA
    Lancet 378:1847-57. 2011
    ..We undertook a phase 1 trial (Stem Cell Infusion in Patients with Ischemic cardiOmyopathy [SCIPIO]) of autologous CSCs for the treatment of heart failure resulting from ischaemic heart disease...
  11. ncbi Long-term proliferation in culture and germline transmission of mouse male germline stem cells
    Mito Kanatsu-Shinohara
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Japan
    Biol Reprod 69:612-6. 2003
    ..Long-term spermatogonial stem cell culture will be useful for studying spermatogenesis mechanism and has important implications for developing new technology in transgenesis or medicine...
  12. pmc Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    Dimitrios Karussis
    Department of Neurology, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem IL 91120, Israel
    Arch Neurol 67:1187-94. 2010
    ....
  13. ncbi Retinal repair by transplantation of photoreceptor precursors
    R E MacLaren
    Division of Molecular Therapy, University College London Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Nature 444:203-7. 2006
    ..These findings define the ontogenetic stage of donor cells for successful rod photoreceptor transplantation...
  14. pmc Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation
    Timothy J Henrich
    Divison of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Infect Dis 207:1694-702. 2013
    The long-term impact of allogeneic hematopoietic stem cell transplantation (HSCT) on human immunodeficiency virus type 1 (HIV-1) reservoirs in patients receiving combination antiretroviral therapy (cART) is largely unknown.
  15. ncbi Direct isolation of satellite cells for skeletal muscle regeneration
    Didier Montarras
    CNRS Unité de Recherche Associée 2578, Department of Developmental Biology, INSERM, Pasteur Institute, 75724 Paris Cedex 15, France
    Science 309:2064-7. 2005
    ..Such cells, grafted into muscles of mdx nu/nu mice, contributed both to fiber repair and to the muscle satellite cell compartment. Expansion of these cells in culture before engraftment reduced their regenerative capacity...
  16. pmc Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells
    Hiroshi Kubota
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:16489-94. 2004
    ..Moreover, the ability to recover, culture indefinitely, and transplant SSCs will make the germ-line of individual males available for periods extending beyond a normal lifetime...
  17. ncbi Isolation of amniotic stem cell lines with potential for therapy
    Paolo De Coppi
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1094, USA
    Nat Biotechnol 25:100-6. 2007
    ....
  18. pmc Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18117-22. 2004
    ..CXCR4 expression within germinal zones suggests that NSC homing after injury and migration during development may invoke similar mechanisms...
  19. ncbi Stem-cell therapy for cardiac disease
    Vincent F M Segers
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Partners Research Facility, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA
    Nature 451:937-42. 2008
    ..These new findings have stimulated optimism that the progression of heart failure can be prevented or even reversed with cell-based therapy...
  20. ncbi Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens
    Rachel Ruckdeschel Smith
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:896-908. 2007
    ..Ex vivo expansion of resident cardiac stem cells, followed by delivery to the heart, may favor regeneration and functional improvement...
  21. pmc Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells
    Francesco Saverio Tedesco
    Division of Regenerative Medicine, San Raffaele Scientific Institute, 58 Via Olgettina, Milan, Italy
    J Clin Invest 120:11-9. 2010
    ..Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined...
  22. ncbi Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
    Birgit Assmus
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 106:3009-17. 2002
    ..The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown...
  23. ncbi Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
    Abeel A Mangi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115 USA
    Nat Med 9:1195-201. 2003
    ..Thus, mesenchymal stem cells genetically enhanced with Akt1 can repair infarcted myocardium, prevent remodeling and nearly normalize cardiac performance...
  24. ncbi Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
    Arman T Askari
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 362:697-703. 2003
    ..We investigated these issues in a Lewis rat model (ligation of the left anterior descending artery) of ischaemic cardiomyopathy...
  25. ncbi Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation
    Jielin Feng
    Department of Cell Biology, Section Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Radiother Oncol 92:466-71. 2009
    ..The aim of this study is to optimize and translate these findings from mice to man...
  26. ncbi In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery
    Feng Cao
    Department of Radiology, Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5344, USA
    Circulation 113:1005-14. 2006
    ..Recent studies have shown that stem cell therapy can promote tissue regeneration; however, monitoring stem cells in vivo remains problematic owing to limitations of conventional histological assays and imaging modalities...
  27. pmc Tracking stem cells using magnetic nanoparticles
    Stacey M Cromer Berman
    Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 3:343-55. 2011
    ..Caveats and limitations inherent to the tracking of nanoparticle-labeled stem cells are also discussed...
  28. ncbi Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction
    Volker Schachinger
    Department of Internal Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1210-21. 2006
    ..Pilot trials suggest that the intracoronary administration of autologous progenitor cells may improve left ventricular function after acute myocardial infarction...
  29. ncbi Isolation and expansion of adult cardiac stem cells from human and murine heart
    Elisa Messina
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Circ Res 95:911-21. 2004
    ....
  30. ncbi Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
    Jong Hoon Kim
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 418:50-6. 2002
    ..The dopamine neurons generated by these stem cells show electrophysiological and behavioural properties expected of neurons from the midbrain. Our results encourage the use of ES cells in cell-replacement therapy for Parkinson's disease...
  31. pmc Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells
    Timothy J Nelson
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 120:408-16. 2009
    ..Induced pluripotent stem cells (iPS) demonstrate aptitude for de novo cardiac differentiation, yet their potential for heart disease therapy has not been tested...
  32. ncbi Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial
    Peter Dreger
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Blood 116:2438-47. 2010
    ..phase 2 trial was to investigate the long-term outcome of reduced-intensity conditioning allogeneic stem cell transplantation (alloSCT) in patients with poor-risk chronic lymphocytic leukemia...
  33. ncbi Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution
    Israel M Barbash
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
    Circulation 108:863-8. 2003
    ..Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI)...
  34. ncbi Mesenchymal stem cells: biology and potential clinical uses
    R J Deans
    Osiris Therapeutics, Baltimore, MD 21231, USA
    Exp Hematol 28:875-84. 2000
    ..Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation...
  35. ncbi Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases
    Chang Hwan Yoon
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Circulation 112:1618-27. 2005
    ..We also investigated whether the combination of these different cell types shows synergism during neovascularization...
  36. ncbi Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow
    E Mezey
    Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Science 290:1779-82. 2000
    ..These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury...
  37. pmc Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
    Mathew Blurton-Jones
    Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:13594-9. 2009
    ..pathogenic forms of amyloid precursor protein, presenilin, and tau to investigate the effect of neural stem cell transplantation on AD-related neuropathology and cognitive dysfunction...
  38. ncbi Stem and progenitor cells in skeletal muscle development, maintenance, and therapy
    Bruno Peault
    Stem Cell Research Center, Children s Hospital of Pittsburgh, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Ther 15:867-77. 2007
    ..As an alternative to myoblast transplantation, stem cells such as mesoangioblasts and CD133+ progenitors administered through blood circulation have recently shown great potential to regenerate dystrophic muscle...
  39. pmc Rescue of salivary gland function after stem cell transplantation in irradiated glands
    Isabelle M A Lombaert
    Section Radiation and Stress Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 3:e2063. 2008
    ..applicable method for the restoration of radiation-impaired salivary gland function using salivary gland stem cell transplantation was developed...
  40. pmc Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
    Brian J Cummings
    Department of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:14069-74. 2005
    ..Glial fibrillary acidic protein-positive astrocytic differentiation was rare, and hCNS-SCns did not appear to contribute to the scar. These data suggest that hCNS-SCns may possess therapeutic potential for CNS injury and disease...
  41. pmc Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
    Marius Wernig
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:5856-61. 2008
    ..Our results demonstrate the therapeutic potential of directly reprogrammed fibroblasts for neuronal cell replacement in the animal model...
  42. ncbi Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs
    Maurilio Sampaolesi
    San Raffaele Scientific Institute, Universita Vita e Salute, Stem Cell Research Institute, Via Olgettina 58, 20132 Milan, Italy
    Nature 444:574-9. 2006
    ..The outcome is a remarkable clinical amelioration and preservation of active motility. These data qualify mesoangioblasts as candidates for future stem cell therapy for Duchenne patients...
  43. ncbi Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality
    Ichiro Sekiya
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Stem Cells 20:530-41. 2002
    ..The results indicate that, when preparing cultures of human MSCs, it is necessary to compromise between conditions that provide the highest overall yields and those that provide the highest content of early progenitor cells...
  44. pmc Reprogramming cellular identity for regenerative medicine
    Anne B C Cherry
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 148:1110-22. 2012
    ....
  45. ncbi Tracking neural stem cells in patients with brain trauma
    Jianhong Zhu
    N Engl J Med 355:2376-8. 2006
  46. ncbi In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
    Dara L Kraitchman
    Johns Hopkins University, School of Medicine, Department of Radiology, 601 N Caroline St, Suite 4231, Baltimore, MD 21287 0845, USA
    Circulation 107:2290-3. 2003
    ..We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model...
  47. ncbi Production of offspring from a germline stem cell line derived from neonatal ovaries
    Kang Zou
    School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    Nat Cell Biol 11:631-6. 2009
    ..These findings contribute to basic research into oogenesis and stem cell self-renewal and open up new possibilities for use of FGSCs in biotechnology and medicine...
  48. ncbi Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice
    Isotta Chimenti
    Cedars Sinai Heart Institute, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Circ Res 106:971-80. 2010
    ..Most prominent among these are direct heart muscle and blood vessel regeneration from transplanted cells, as opposed to paracrine enhancement of tissue preservation and/or recruitment of endogenous repair...
  49. pmc Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration
    Zhuqing Qu-Petersen
    Growth and Development Laboratory, Children s Hospital of Pittsburgh, Department of Orthopaedic Surgery, University of Pittsburgh, PA 15260, USA
    J Cell Biol 157:851-64. 2002
    ..Our results suggest that this novel population of muscle-derived stem cells will significantly improve muscle cell-mediated therapies...
  50. ncbi Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice
    Willy A Noort
    Department of Hematology, Leiden University Medical Center, Leiden University Medical Center, The Netherlands
    Exp Hematol 30:870-8. 2002
    ..In cotransplantation experiments, we examined the homing of MSC as well as the effect on engraftment of human umbilical cord blood (UCB)-derived CD34(+) cells in NOD/SCID mice...
  51. pmc Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization
    T Murohara
    The Cardiovascular Research Institute, Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    J Clin Invest 105:1527-36. 2000
    ..In conclusion, umbilical cord blood is a valuable source of EPCs, and transplantation of cord blood-derived EPCs represents a promising strategy for modulating postnatal neovascularization...
  52. pmc Human cardiac stem cells
    Claudia Bearzi
    Department of Medicine, Cardiovascular Research Institute, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 104:14068-73. 2007
    ..Thus, hCSCs can be isolated and expanded in vitro for subsequent autologous regeneration of dead myocardium in patients affected by heart failure of ischemic and nonischemic origin...
  53. ncbi Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury
    Soheila Karimi-Abdolrezaee
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:3377-89. 2006
    ..Our data provide strong evidence in support of the feasibility of adult NPCs for cell-based remyelination after SCI...
  54. pmc Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges
    Jörn Tongers
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Eur Heart J 32:1197-206. 2011
    ..In this context, cell priming, bionanotechnology, and tissue engineering are emerging tools and may merge into a combined biological approach of ischaemic tissue repair...
  55. ncbi Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury
    J Dawn Abbott
    Department of Cardiology, Yale University Medical School, New Haven, Conn, USA
    Circulation 110:3300-5. 2004
    ..The mechanisms determining BMDC recruitment to the heart remain unclear. We investigated the role of stromal cell-derived factor-1alpha (SDF-1) in this process...
  56. pmc Stem cells in human neurodegenerative disorders--time for clinical translation?
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    J Clin Invest 120:29-40. 2010
    ..In particular, we need to better understand the mechanisms of action of stem cells after transplantation and learn how to control stem cell proliferation, survival, migration, and differentiation in the pathological environment...
  57. pmc Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells
    Deepak A Lamba
    Department of Biological Structure, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e8763. 2010
    ..To provide a source of new retinal neurons for cell based therapies, we developed methods to derive retinal progenitors from human ES cells...
  58. ncbi Clinical outcome 2 years after intracoronary administration of bone marrow-derived progenitor cells in acute myocardial infarction
    Birgit Assmus
    J W Goethe Universitat, Division of Cardiology, Frankfurt, Germany
    Circ Heart Fail 3:89-96. 2010
    ..The aim of this study was to investigate the clinical outcome 2 years after intracoronary administration of autologous progenitor cells in patients with acute myocardial infarction (AMI)...
  59. ncbi Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation
    Carlos Fernández de Larrea
    Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Clin Cancer Res 18:3697-704. 2012
    ..The aim of this study was to ascertain the prognostic impact of six miRSNPs in patients with multiple myeloma and analyze the functional consequences...
  60. pmc Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation
    Husnain Kh Haider
    Department of Pathology and Laboratory Medicine, 231 Albert Sabin Way, University of Cincinnati, OH 45267 0529, USA
    J Mol Cell Cardiol 45:554-66. 2008
    b>Stem cell transplantation has emerged as a potential modality in cardiovascular therapeutics due to their inherent characteristics of self-renewal, unlimited capacity for proliferation and ability to cross lineage restrictions and adopt ..
  61. ncbi Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I safety trial, technical note, and lumbar safety outcomes
    Jonathan Riley
    Department of Neurosurgery, Emory University, Atlanta, Georgia 30322, USA
    Neurosurgery 71:405-16; discussion 416. 2012
    ....
  62. pmc Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors
    Emma L West
    Department of Genetics, UCL Institute of Ophthalmology, University College London, United Kingdom
    Stem Cells 30:1424-35. 2012
    ..Despite showing expression profiles characteristic of immature photoreceptors, the ESC-derived precursors generated using this protocol did not display transplantation competence equivalent to precursors from the postnatal retina...
  63. pmc In vivo MRI cell tracking: clinical studies
    Jeff W M Bulte
    Russell H Morgan Department of Radiology, Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AJR Am J Roentgenol 193:314-25. 2009
    ..The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed...
  64. pmc Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair
    Tao Sheng Li
    Cedars Sinai Heart Institute, Los Angeles, California 90048, USA
    Stem Cells 28:2088-98. 2010
    ..These changes underlie an increase in cell survival and more potent augmentation of global function following implantation into the infarcted heart...
  65. ncbi Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
    Soon Tae Lee
    Stroke and Stem Cell Laboratory, Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Brain 131:616-29. 2008
    ..In summary, early intravenous NSC injection displayed anti-inflammatory functionality that promoted neuroprotection, mainly by interrupting splenic inflammatory responses after ICH...
  66. ncbi Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells
    Yusuke Fujimoto
    Laboratory of Molecular Neuroscience, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan
    Stem Cells 30:1163-73. 2012
    ..Our findings indicate that hiPS-lt-NES transplantation represents a promising avenue for effective cell-based treatment of SCI...
  67. ncbi Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation
    T Lion
    Children s Cancer Research Institute, Vienna, Austria
    Leukemia 24:706-14. 2010
    ..Quantitative monitoring of the AdV load in stool specimens therefore provides a rationale for early initiation of antiviral treatment with the aim of preventing progression to life-threatening invasive infection...
  68. pmc Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling
    Luciola S Barcelos
    Bristol Heart Institute, University of Bristol, Upper Maudlin Street, Bristol, United Kingdom
    Circ Res 104:1095-102. 2009
    ..CD133(+) cells stimulate wound healing by paracrine mechanisms that activate Wnt signaling pathway in recipients. These preclinical findings open new perspectives for the cure of diabetic ulcers...
  69. pmc Aging and disease as modifiers of efficacy of cell therapy
    Stefanie Dimmeler
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circ Res 102:1319-30. 2008
    ..Pretreatment of cells or the target tissue by small molecules, polymers, growth factors, or a combination thereof may provide useful approaches for enhancement of cell therapy for cardiovascular diseases...
  70. pmc Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice
    Katsuhisa Matsuura
    Department of Cardiology, Tokyo Women s Medical University, Tokyo, Japan
    J Clin Invest 119:2204-17. 2009
    ..These results suggest that CPC transplantation improves cardiac function after myocardial infarction through cardiomyocyte differentiation and paracrine mechanisms mediated via the sVCAM-1/VLA-4 signaling pathway...
  71. ncbi Transplantation of endothelial progenitor cells improves neovascularization and left ventricular function after myocardial infarction in a rat model
    Alexander Schuh
    IZKF BIOMAT, Aachen, Germany
    Basic Res Cardiol 103:69-77. 2008
    ..These results imply a combined benefit of EPCs+SDF-1alpha in the treatment of myocardial infarction...
  72. pmc Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages
    Gianni Carraro
    Developmental Biology, Regenerative Medicine and Surgery Program, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine and School of Dentistry, Los Angeles, California 90027, USA
    Stem Cells 26:2902-11. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  73. ncbi Stem Cell Therapy as an Emerging Paradigm for Stroke (STEPS) II
    Sean I Savitz
    Department of Neurology, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Stroke 42:825-9. 2011
    ....
  74. ncbi Mesenchymal stem cells for clinical application
    L Sensebe
    Etablissement Français du Sang GECSoM, Tours cedex 3, France
    Vox Sang 98:93-107. 2010
    ..For answering to the numerous challenges in this fast developing field of biology and medicine, integrative networks linking together research teams, cell therapy laboratories and clinical teams are needed...
  75. ncbi Stem cell therapy in a caprine model of osteoarthritis
    J Mary Murphy
    Osiris Therapeutics, Baltimore, Maryland 21231, USA
    Arthritis Rheum 48:3464-74. 2003
    ....
  76. ncbi Primate spermatogonial stem cells colonize mouse testes
    M Nagano
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6009, USA
    Biol Reprod 64:1409-16. 2001
    ..Because germ cell differentiation and spermatogenesis did not occur, the molecules necessary for this process appear to have undergone greater divergence between baboon and mouse...
  77. ncbi Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
    Tiziano Barberi
    Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Biotechnol 21:1200-7. 2003
    ..Furthermore, transplantation of ES and ntES cell-derived dopaminergic neurons corrected the phenotype of a mouse model of Parkinson disease, demonstrating an in vivo application of therapeutic cloning in neural disease...
  78. ncbi Slowed progression in models of Huntington disease by adipose stem cell transplantation
    Soon Tae Lee
    Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea
    Ann Neurol 66:671-81. 2009
    ..Adipose-derived stem cells (ASCs) are readily accessible and secrete multiple growth factors. Here, we show that ASC transplantation rescues the striatal pathology of Huntington disease (HD) models...
  79. ncbi Influence of cardiovascular risk factors on endothelial progenitor cells: limitations for therapy?
    Nikos Werner
    Medizinischen Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    Arterioscler Thromb Vasc Biol 26:257-66. 2006
    ....
  80. pmc Chemokines regulate the migration of neural progenitors to sites of neuroinflammation
    Abdelhak Belmadani
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurosci 26:3182-91. 2006
    ..These data indicate that factors secreted by sites of neuroinflammation are attractive to neural progenitors and suggest that chemokines such as MCP-1 play an important role in this process...
  81. ncbi Feeder layer- and serum-free culture of human embryonic stem cells
    M Amit
    Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 31096 Haifa, Israel
    Biol Reprod 70:837-45. 2004
    ..The feeder layer-free culture system reported here aims at facilitating research practices and providing a safer alternative for future clinical applications of hES cells...
  82. pmc Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient
    Ninette Amariglio
    Cancer Research Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS Med 6:e1000029. 2009
    ..However, concerns have been raised over the safety of this experimental therapeutic approach, including, for example, whether there is the potential for tumors to develop from transplanted stem cells...
  83. ncbi Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response
    Jeannette Nussbaum
    Department of Pathology, University of Washington, Seattle, WA, USA
    FASEB J 21:1345-57. 2007
    ..Successful cardiac repair strategies involving ES cells will need to control cardiac differentiation, avoid introducing undifferentiated cells, and will likely require immune modulation to avoid rejection...
  84. pmc Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source
    J R Beauchamp
    Muscle Cell Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Cell Biol 144:1113-22. 1999
    ..This minority is behaviorally distinct, slowly dividing in tissue culture, but rapidly proliferative after grafting, suggesting a subpopulation with stem cell-like characteristics...
  85. ncbi Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies
    Christof Stamm
    Department of Cardiac Surgery, University of Rostock, Rostock, Germany
    J Thorac Cardiovasc Surg 133:717-25. 2007
    ..We then tested the hypothesis that CABG plus CD133+ cell injection would result in better contractile function than CABG alone...
  86. pmc Niche-independent symmetrical self-renewal of a mammalian tissue stem cell
    Luciano Conti
    Institute for Stem Cell Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 3:e283. 2005
    ..These homogenous cultures will enable delineation of molecular mechanisms that define a tissue-specific stem cell and allow direct comparison with pluripotent ES cells...
  87. pmc Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction
    Xian Liang Tang
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circulation 121:293-305. 2010
    ..Therefore, we sought to determine whether CPCs are beneficial in the more clinically relevant setting of an old MI (scar)...
  88. ncbi Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial
    Stefan Janssens
    Department of Cardiology, Gasthuisberg University Hospital, University of Leuven, Leuven, Belgium
    Lancet 367:113-21. 2006
    ..Our aim was to investigate the effect of autologous bone marrow-derived stem cell (BMSC) transfer in the infarct-related artery on LV function and structure...
  89. ncbi Autologous stem cell transplantation as a first-line treatment strategy for chronic lymphocytic leukemia: a multicenter, randomized, controlled trial from the SFGM-TC and GFLLC
    Laurent Sutton
    Department of Clinical Hematology, Victor Dupouy Hospital, Argenteuil, France
    Blood 117:6109-19. 2011
    Long-term responses have been reported after autologous stem cell transplantation (ASCT) for chronic lymphocytic leukemia (CLL). We conducted a prospective, randomized trial of ASCT in previously untreated CLL patients...
  90. ncbi Prospects for stem cell transplantation in the treatment of hepatic disease
    Benjamin M Stutchfield
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Liver Transpl 16:827-36. 2010
    ..Ultimately, the most appropriate hepatic disease targets for stem cell therapies will become apparent as mechanisms of stem involvement in hepatic regeneration are further elucidated...
  91. pmc Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells
    Yang D Teng
    Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:3024-9. 2002
    ..These results may suggest a new approach to SCI and, more broadly, may serve as a prototype for multidisciplinary strategies against complex neurological problems...
  92. pmc Cell therapy for spinal cord injury by neural stem/progenitor cells derived from iPS/ES cells
    Osahiko Tsuji
    Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Neurotherapeutics 8:668-76. 2011
    ..stem cells and embryonic stem cells has raised great expectations for the successful clinical use of stem cell transplantation therapy...
  93. pmc Cell therapy for cardiovascular disease: a comparison of methods of delivery
    Nabil Dib
    Mercy Gilbert and Chandler Regional Medical Centers, 3555 S Val Vista Dr, Gilbert, AZ 85297, USA
    J Cardiovasc Transl Res 4:177-81. 2011
    ..This review discusses the advantages and disadvantages of the delivery approaches above...
  94. pmc Comparison of different adult stem cell types for treatment of myocardial ischemia
    Koen E A van der Bogt
    Laboratory of Cardiothoracic Transplantation, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Circulation 118:S121-9. 2008
    ..This study is designed to evaluate the therapeutic efficacy of 4 cell types in a murine model of myocardial infarction...
  95. pmc Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial
    Josep Maria Ribera
    Department of Hematology of the Hospitals Institut Català d Oncologia Hospital Germans Trias i Pujol, Badalona, Spain
    Haematologica 95:87-95. 2010
    ..of this study was to evaluate the feasibility and results of giving imatinib concurrently with intensive chemotherapy, stem cell transplantation and post-transplant imatinib maintenance therapy in patients with newly diagnosed Ph(+) ALL.
  96. ncbi Electromechanical integration of cardiomyocytes derived from human embryonic stem cells
    Izhak Kehat
    The Sohnis Family Research Laboratory for the Regeneration of Functional Myocardium, Department of Biophysics and Physiology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa, Israel
    Nat Biotechnol 22:1282-9. 2004
    ..These results demonstrate the potential of hES-cell cardiomyocytes to act as a rate-responsive biological pacemaker and for future myocardial regeneration strategies...
  97. ncbi A prospective study on the epidemiology of febrile episodes during chemotherapy-induced neutropenia in children with cancer or after hemopoietic stem cell transplantation
    Elio Castagnola
    Infectious Diseases Unit, G Gaslini Children Hospital, Genoa, Italy
    Clin Infect Dis 45:1296-304. 2007
    ..The purpose of our study was to evaluate the incidence and clinical characteristics of febrile episodes during neutropenia following chemotherapy in children with cancer...
  98. pmc Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation
    Bruno Paiva
    Hospital Universitario de Salamanca, Salamanca, Spain
    Blood 112:4017-23. 2008
    ..diagnosed MM patients uniformly treated in the GEM2000 protocol VBMCP/VBAD induction plus autologous stem cell transplantation [ASCT]). MRD status by MFC was determined at day 100 after ASCT...
  99. ncbi Generation of pluripotent stem cells from adult mouse liver and stomach cells
    Takashi Aoi
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Science 321:699-702. 2008
    ..These data suggest that iPS cells are generated by direct reprogramming of lineage-committed somatic cells and that retroviral integration into specific sites is not required...
  100. ncbi Stem cells for the treatment of neurological disorders
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Nature 441:1094-6. 2006
    ..The next step is to translate these exciting advances from the laboratory into clinically useful therapies...
  101. pmc Cardiac cell repair therapy: a clinical perspective
    Bernard J Gersh
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:876-92. 2009
    ..An interdisciplinary effort across the scientific and clinical community within academia, biotechnology, and government will drive the successful realization of this next generation of therapeutic agents for the "broken" heart...

Research Grants78

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Title: The Natural History of Ocular Graft-Versus Host Disease Number: 11-EI-0173 Summary: Background: - Stem cell transplantation (SCT) is used to treat some kinds of cancer, blood cell disorders, and immune disorders...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Title: The Natural History of Ocular Graft-Versus Host Disease Number: 11-EI-0173 Summary: Background: - Stem cell transplantation (SCT) is used to treat some kinds of cancer, blood cell disorders, and immune disorders...
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..In addition, we have been prospectively evaluating new approaches to stem cell transplantation in order to decrease morbidity and increase access for patients without allogeneic matches64-67...
  4. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..of Function</keyword;keyword>Seizures/prevention &amp;control</keyword;keyword>*Stem Cell Transplantation</keyword;keyword>Swine</keyword;/keywords;dates;year>2000</year;pub-dates;date>Jun</..
  5. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) is an established treatment for benign and malignant hemato- logic diseases in children...
  6. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    Allogeneic stem cell transplantation (allo-SCT) is potentially curative therapy for a patients suffering from leukemia, lymphoma and multiple myeloma...
  7. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..months, yet these patients are often ineligible for life-saving high dose chemotherapy and autologous stem cell transplantation. It results from the deposition of misfolded amyloid proteins derived from immunoglobulin light chains ..
  8. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..b>Stem cell transplantation is the treatment of choice for eligible patients with bone marrow failure...
  9. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..b>Stem cell transplantation is the treatment of choice for eligible patients with bone marrow failure...
  10. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (HSCT) is a therapeutic procedure that is used to treat advanced hematologic malignancies or other blood disorders...
  11. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..Graft-versus-host disease (GvHD) is the major limiting factor to the widespread use of allogeneic stem cell transplantation. GvHD is due to the recognition by donor T cells of minor or major MHC disparities found on antigen-..
  12. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..Hematopoietic stem cell transplantation can reduce some manifestations, but has a 15% mortality rate, costs $130,000, and requires a compatible ..
  13. Hematopoietic Stem Cell Transplantation in Osteogenesis Imperfecta
    Meenal Mehrotra; Fiscal Year: 2012
    ..Long term, these findings have the potential to identify HSC transplantation, and not the transplantation of MSCs or progenitor cells, as the therapy of choice for this collagen disorder. ..
  14. SATB1-dependent epigenetic regulation of leukemia initiating cells
    Britta Will; Fiscal Year: 2011
    ..gene expression regulation in HSC and LIC will be characterized using in vivo models, such as stem cell transplantation assays...
  15. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2012
    ..Project Narrative Although hematopoietic stem cell transplantation is the only curative therapy for many blood-related disorders, associated risks often limit the ..
  16. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..and KUMC that collaborates on the conduct of clinical trials for autologous and allogeneic hematopoietic stem cell transplantation (HSCT)...
  17. Novel Hematopoietic Conditioning Agents for Treatment of Hematological Diseases
    Olga B Chernova; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) has increased the survival of children and adults afflicted with malignant and non-malignant hematological diseases...
  18. Muscle stem cell therapy in a mouse model of premature aging
    Johnny Huard; Fiscal Year: 2010
    ..of stem cell therapies which could delay or ameliorate the pathologies associated with aging;therefore, identifying strategies, such as stem cell transplantation, is essential for maintaining the health of our aging population.
  19. Optimization of adoptive immunotherapy with autologous CD20-specific T cells
    Brian Till; Fiscal Year: 2013
    ..and infused into patients with relapsed or refractory aggressive B cell lymphoma following autologous stem cell transplantation. We believe this approach addresses several of the weaknesses identified in our two previous CD20 CAR ..
  20. T-cell Therapy for B-lineage Acute Lymphoblastic Leukemia
    Laurence J N Cooper; Fiscal Year: 2013
    ..LAY SUMMARY: We will infuse CD19-specific T cells after transplantation to improve survival for patients with acute lymphoblastic leukemia. ..
  21. DNA Methylation Control Hematopoietic Stem Cell Lineage Differentiation
    GRANT ANTHONY CHALLEN; Fiscal Year: 2013
    ..diverse interests of the faculty of these Centers includes hematopoiesis, stem cell biology, hemopoietic stem cell transplantation, gene therapy, immunotherapy, and vector development and provides ample opportnity for collaboration to ..
  22. Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
    Grover Bagby; Fiscal Year: 2009
    ..b>Stem cell transplantation is the treatment of choice for eligible patients with bone marrow failure...
  23. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
    ..Hematopoietic stem cell transplantation (HSCT) is highly curative (up to 95% survival) only if the SCID infants are recognized early in life, ..
  24. Prevention of acute GvHD by inhibition of cdk2
    Vassiliki A Boussiotis; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) can cure a variety of benign and malignant diseases but graft versus host disease (GvHD), mediated by donor T cells, remains a primary cause of ..
  25. Mechanisms mediating hematopoietic stem and progenitor cell trafficking
    Paul S Frenette; Fiscal Year: 2013
    ..the regeneration of the niche and recovery of hematopoiesis following a stressful challenge such as stem cell transplantation or 5-fluorouracyl (5FU) administration...
  26. Investigating the role of interleukin-22 in thymus function
    Jarrod Dudakov; Fiscal Year: 2013
    ..This is particularly relevant for recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT), who experience prolonged post-transplant T cell deficiency caused by cytoreductive ..
  27. IL-22 in Thymic Regeneration
    Marcel R m van den Brink; Fiscal Year: 2013
    ..This is particularly relevan for recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT), who experience prolonged post-transplant T cell deficiency caused by cytoreductive ..
  28. Mucosal Immunity and Microbiota in Intestinal Graft-versus-Host Disease
    Marcel R m van den Brink; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic bone marrow or hematopoietic stem cell transplantation (allo BMT) is an important therapy with curative potential for a variety of malignant and non-malignant diseases...
  29. Lentiviral-transduced hematopoictic stem cell transplantation for cystinosis
    Stephanie Cherqui; Fiscal Year: 2013
    ..As pre-clinical studies, we will use the mouse model for cystinosis that accumulates cystine in all the tissues and develops similar defects to those of the human children. ..
  30. Advanced Magnetization Transfer Imaging in Multiple Sclerosis Disease
    Alexey Samsonov; Fiscal Year: 2012
    ..to measure the effectiveness of emerging approaches to neuroprotection and myelin repair, such as stem cell transplantation. Ultimately, developing these biomarkers will allow identification of patients who are most likely to ..
  31. Identification of stromal responses during castration-induced thymic regrowth.
    Howard T Petrie; Fiscal Year: 2013
    ..Decreased capacity to make new T cells is also a substantial limitation in hematopoietic stem cell transplantation, which is an established therapy for diseases like leukemia, and an emerging therapy for autoimmune ..
  32. Beta-Globin Gene Correction Using Peptide Nucleic Acids for the Treatment of Sick
    GERALD FRANCIS VOVIS; Fiscal Year: 2010
    ..Allogeneic hematopoietic stem cell transplantation is curative, although such a treatment typically requires an HLA-matched donor, is associated with ..
  33. System for Rapid Generation of Aptamers for Transplant Therapies
    KAREN QIAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Autologous hematopoietic stem cell transplantation (HSCT) has been an important treatment option for many patients with hematologic malignancies and solid tumors such as acute myeloid leukemia, ..
  34. Development of Human, Autologous, Pluripotent Very Small Embryonic Like (VSELs) s
    DENIS OVEREND RODGERSON; Fiscal Year: 2013
    ..There is only one intervention that saves a fatally irradiated person - a rescue through stem cell transplantation. The cure rate for this treatment can be high, provided the treatment is delivered within 7-10 days ..
  35. Triplex-mediated DNA repair as a novel therapy for Hurler Syndrome patients
    Elizabeth Peterson-Roth; Fiscal Year: 2012
    ..Alternatively, allogeneic hematopoietic stem cell transplantation (HSCT) represents a highly effective treatment...
  36. Transplant Associated Infection Surveillance Network Phase II
    PETER GEORGE PAPPAS; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Organ and hematopoietic stem cell transplantation has become an increasingly important and life saving measure for thousands of persons each year in the ..
  37. Stem Cells For Myocardial Repair: A Large Bore Magnet Study
    Jianyi Zhang; Fiscal Year: 2012
    ..This proposal will examine whether a PEGylated fibrin patch based stem cell transplantation can provide a new regeneration therapy for heart failure patients.
  38. Nanoliposome-based Treatment of Amyloid Protein (AL) Toxicity
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2013
    ..Chemotherapy[unreadable]stem cell transplantation, the only treatment available, has high treatment- related mortality and incomplete success rate...
  39. A search for genes that regulate allogeneic stem cell competition
    Irving L Weissman; Fiscal Year: 2013
    ..that may regulate stem cell competition in Botryllus, (ii) investigate the role of selected genes in stem cell transplantation engraftment and competitive repopulation of tissues, and (iii) investigate the potential role of genes ..
  40. Novel mechanisms of immune activation following allogeneic, hematopoietic stem ce
    JOHN JAMES LETTERIO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for many patients with hematologic malignancies and other blood disorders...
  41. Targeted Therapies and Mechanisms of Resistance in Chronic Lymphocytic Leukemia
    Jennifer A Woyach; Fiscal Year: 2013
    ..leukemia (CLL) is the most prevalent form of adult leukemia and is currently incurable outside of stem cell transplantation. Fludarabine-based chemoimmunotherapy is standard initial therapy for younger patients with CLL, while ..
  42. Novel Immunodeficiency caused by TFRC Mutation
    RAIF SALIM GEHA; Fiscal Year: 2013
    ..of cord blood lymphocytes for increased TfR1 surface expression, early intervention with hematopoietic stem cell transplantation (HSCT), and genetic counseling...
  43. Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B Cells
    Elizabeth J Shpall; Fiscal Year: 2013
    ....
  44. Skin-targeted Cell Therapy for Recessive Dystrophic Epidermolysis Bullosa
    Jakub Tolar; Fiscal Year: 2013
    ..We have shown that hematopoietic stem cell transplantation (HSCT) can increase C7 protein in skin and mucous membranes, and ameliorate many of the disease ..
  45. Identification of Stromal Responses During Castration Mediated Thymic Regrowth
    ANN VENABLES GRIFFITH; Fiscal Year: 2011
    ..Decreased capacity to make new T cells is also a substantial limitation in hematopoietic stem cell transplantation, which is an established therapy for diseases like leukemia, and an emerging therapy for autoimmune ..
  46. Myxoma Virus (MV) Oncolysis for treating human cancer
    Grant McFadden; Fiscal Year: 2013
    ..human bone marrow or mobilized-PBMC samples from patients who would normally be excluded from autologous stem cell transplantation following high dose chemotherapy...
  47. Role of PGE2 and other eicosanoids in hematopoietic stem cell function
    Louis M Pelus; Fiscal Year: 2013
    ..We believe that the information we derive can be directly translated to improve hematopoietic stem cell transplantation.Eicosanoids are physiological lipids that include prostaglandins, prostacyclins, thromboxanes, ..
  48. IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHY
    Shahriar Yaghoubi; Fiscal Year: 2013
    ..These studies will establish principles and practices for translating PET-based imaging of CAR+ T cells and provide the first human imaging data on the biodistribution of genetically modified T cells. ..
  49. Phase 2 Study of Abatacept with Calcineurin Inhibition and Methotrexate for GVHD
    Leslie S Kean; Fiscal Year: 2013
    DESCRIPTION: (provided by the applicant) Hematopoietic stem cell transplantation (HSCT) often represents the only chance for cure for patients diagnosed with aggressive leukemias and other hematologic malignancies...
  50. CD8+ T Cell Immunity to Cytomegalovirus
    Stanley R Riddell; Fiscal Year: 2013
    ..infection is a major cause of morbidity and mortality in patients who undergo allogeneic hematopoietic stem cell transplantation and require systemic corticosteroids to treat graft versus host disease...
  51. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2012
    ..on developing a career as a physician/scientist with expertise in hematology/oncology, hematopoietic stem cell transplantation (HSCT) and human immunology...
  52. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2013
    ..on developing a career as a physician/scientist with expertise in hematology/oncology, hematopoietic stem cell transplantation (HSCT) and human immunology...
  53. Radioimmunotherapy for Multiple Myeloma
    Damian J Green; Fiscal Year: 2013
    ..High dose chemotherapy followed by autologous stem cell transplantation (ASCT) leads to increased rates of complete remission and prolonged periods of disease free survival, ..
  54. SPORE in Lymphoma
    Richard Ambinder; Fiscal Year: 2009
    ..T cells specific for EBV proteins expressed in HL in the context of high dose therapy with peripheral stem cell transplantation. Specific Aims 2 and 3 will be conducted at the Johns Hopkins Hospital, the Brigham and Women's ..
  55. Delta-like ligand 4+ dendritic cells and induction of alloimmunity
    Yi Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for many hematological malignancies resistant to other therapies...
  56. The role of complement system in alloimmune responses
    Qing Ma; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Allogeneic stem cell transplantation (allo-HSCT) is an effective therapy for hematological malignancies...
  57. The role of Atg16L1 in Graft-Versus-Host-Disease
    VANESSA MARIE HUBBARD-LUCEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Objectives: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a common therapeutic modality for a number of malignant diseases...
  58. Designing a Microenvironment Niche for Liver-Specific Differentiation of hESCs
    Alexander Revzin; Fiscal Year: 2013
    ..growth factor- containing scaffolds as a way of bridging in vitro hESC differentiation studies and stem cell transplantation experiments...
  59. Ferritin-Based Molecular Imaging of Cardiac Stem Cell Therapy
    Chun Yuan; Fiscal Year: 2010
    ..b>Stem cell transplantation is a promising therapeutic approach for heart failure...
  60. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2013
    ..unwanted immune responses that occur during autoimmune disease or as a consequence of hematopoietic stem cell transplantation (HSCT) or tissue transplant rejection reactions...
  61. Cardiac Regenerative Therapy with Cyclin A2
    Hina W Chaudhry; Fiscal Year: 2010
    ..offers a new and exciting approach to cardiac regeneration in the face of controversial results of stem cell transplantation as a method to achieve myogenesis...
  62. Targeted Improvement in Stem Cell Therapy for Leukemia and Bone Marrow Failure Sy
    Qishen Pang; Fiscal Year: 2013
    ..not only improve mechanistic understanding of stem cell mobilization and engraftment in the context of stem cell transplantation, but also lead to a new avenue of research designed to target Cdc42 for developing innovative ..
  63. Cytokine Induced CD26 Modulation of Adult Hematopoietic Stem Cell Trafficking
    Kent Christopherson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hematopoietic stem cell transplantation (HSCT) is a successful treatment option for many patients with severe hematologic diseases...
  64. Targeting the leukemia microenvironment by CXCR4 inhibition in stem cell transpla
    Marina Y Konopleva; Fiscal Year: 2010
    ..Allogeneic stem cell transplantation is an effective treatment for AML in first remission, with approximately 60% achieving long-term ..
  65. Substrata Interactions of Normal and Leukemic Hematopoietic Stem Cells
    Jane Liesveld; Fiscal Year: 2009
    ..Understanding these interactions would therefore have implications for normal stem cell transplantation and for therapy of various types of leukemias...
  66. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ..These neuro-psychological abnormalities are not adequately corrected by hematopoietic stem cell transplantation (via bone marrow transplantation; BMT)...
  67. OPTIMIZING ALLOGENEIC TRANSPLANTATION USING CXCR4 BLOCKADE
    John F DiPersio; Fiscal Year: 2010
    ..blood has largely replaced bone marrow as a source of stem cells for both autologous and allogeneic stem cell transplantation. Granulocyte Colony Stimulating Factor (G-CSF) with or without chemotherapy has become the standard of ..
  68. Stem Cell Transplantation for Hemoglobinopathies in Dogs
    JOHN HEARST; Fiscal Year: 2003
    ..the completion of this validation through the support of US Public Health Service Grant R01 HL63456 "Stem Cell Transplantation to Establish AIIochimerism," this project is now entering a development phase that should ultimately ..
  69. Cord Blood Stem Cell Transplantation, Hemoglobinopathies
    JOHN HEARST; Fiscal Year: 2003
    ..the completion of this validation through the support of US Public Health Service Grant R01 HL63456, "Stem Cell Transplantation to Establish Allochimerism," this project is now entering a development phase that should ultimately ..
  70. HGF Induces Robust Human Thymopoiesis in Mice
    Jan Nolta; Fiscal Year: 2004
    Over the past decade, the use of immune deficient mice as recipients for human hematopoietic stem cell transplantation has dramatically improved stem cell research...
  71. GM-CSF secreting tumor cell vaccines to enhance post-transplant anti-CLL immunity
    Catherine Wu; Fiscal Year: 2009
    ..as demonstrated by observations of the graft-versus-leukemia (GvL) effect after hematopoietic stem cell transplantation and donor lymphocyte infusion (DLI)...
  72. DLI using genetically modified T cells: Phase 1 trial
    John Dipersio; Fiscal Year: 2005
    ..donor lymphocyte infusions in patients who have relapsed hematologic malignancies after allogeneic stem cell transplantation (SCT)...
  73. Restoring Hematopoiesis Following Radiation Injury
    Amelia Bartholomew; Fiscal Year: 2005
    ..neutropenia, can be treated with both colony-stimulating factors, aggressive use of anti-microbials, and stem cell transplantation. The strategy involving allogeneic stem cell transplantation, due to the morbidity and mortality ..
  74. Immune Recovery Following LLME Treated Cell Therapy
    Joanne Filicko; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Allogeneic hematopoietic stem cell transplantation (HSCT) is the preferred therapy for a variety of disorders...
  75. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..by applicant): Delayed reconstitution of antigen-specific immunity following allogeneic hematopoietic stem cell transplantation (HSCT) predisposes patients to opportunistic infections and tumor recurrence...
  76. Effect of recipient age /graft vs host disease post BMT
    RAYMOND HUTCHISON; Fiscal Year: 2001
    Murine models of hematopoietic stem cell transplantation will be utilized to investigate the association between advancing age and more severe graft-vs.-host disease (GVHD)...
  77. ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
    Robert Sackstein; Fiscal Year: 2003
    DESCRIPTION: (Applicant's Abstract) Allogeneic hematopoietic stem cell transplantation (HSCT) is curative therapy for hematologic malignancies, aplastic anemia and a variety of genetic conditions; however, significant treatment-related ..
  78. CELLULAR IMMUNOTHERAPY FOR HEMATOLOGIC MALIGNANCY
    John Levine; Fiscal Year: 2006
    ..The candidate, Dr. John Levine, is a junior faculty member in the Blood and Marrow Stem Cell Transplantation Program at the University of Michigan. Dr...