lung transplantation

Summary

Summary: The transference of either one or both of the lungs from one human or animal to another.

Top Publications

  1. ncbi Bronchiolitis obliterans syndrome: the final frontier for lung transplantation
    Jamie L Todd
    Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 140:502-8. 2011
  2. ncbi Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection
    Susan Stewart
    Papworth Everard Pathology Department, Papworth Hospital, Cambridge, UK
    J Heart Lung Transplant 26:1229-42. 2007
  3. ncbi Normothermic ex vivo lung perfusion in clinical lung transplantation
    Marcelo Cypel
    Toronto Lung Transplant Program, University of Toronto, ON, Canada
    N Engl J Med 364:1431-40. 2011
  4. ncbi Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria
    Marc Estenne
    Erasme University Hospital, Brussels, Belgium
    J Heart Lung Transplant 21:297-310. 2002
  5. ncbi International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation
    Jonathan B Orens
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 25:745-55. 2006
  6. pmc Non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation
    W Chalermskulrat
    Lung Transplantation Program and Cystic Fibrosis Research and Treatment Center, Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, USA
    Thorax 61:507-13. 2006
  7. ncbi Impact of graft colonization with gram-negative bacteria after lung transplantation on the development of bronchiolitis obliterans syndrome in recipients with cystic fibrosis
    J Gottlieb
    Department of Respiratory Medicine OE6870, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Respir Med 103:743-9. 2009
  8. ncbi Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1454-9. 2005
  9. pmc Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation
    L Fan
    Department of General Surgery, The First Affiliated Hospital, Xi an Jiaotong University School of Medicine, Xi an, China
    Am J Transplant 11:911-22. 2011
  10. ncbi A mouse model of orthotopic vascularized aerated lung transplantation
    M Okazaki
    Division of Cardiothoracic Surgery, Department of Surgery, Washington University in St Louis, St Louis, MO, USA
    Am J Transplant 7:1672-9. 2007

Research Grants

Detail Information

Publications358 found, 100 shown here

  1. ncbi Bronchiolitis obliterans syndrome: the final frontier for lung transplantation
    Jamie L Todd
    Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 140:502-8. 2011
    ..In addition, we underscore emerging clinical implications and promising future translational research directions that have the potential to advance our knowledge and improve patient outcomes...
  2. ncbi Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection
    Susan Stewart
    Papworth Everard Pathology Department, Papworth Hospital, Cambridge, UK
    J Heart Lung Transplant 26:1229-42. 2007
    ..for the grading of pulmonary allograft rejection was adopted by the International Society for Heart and Lung Transplantation (ISHLT) and was modified in 1995 by an expanded group of pathologists...
  3. ncbi Normothermic ex vivo lung perfusion in clinical lung transplantation
    Marcelo Cypel
    Toronto Lung Transplant Program, University of Toronto, ON, Canada
    N Engl J Med 364:1431-40. 2011
    ..In this study, we examined the feasibility of transplanting high-risk donor lungs that have undergone EVLP...
  4. ncbi Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria
    Marc Estenne
    Erasme University Hospital, Brussels, Belgium
    J Heart Lung Transplant 21:297-310. 2002
  5. ncbi International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation
    Jonathan B Orens
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 25:745-55. 2006
  6. pmc Non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation
    W Chalermskulrat
    Lung Transplantation Program and Cystic Fibrosis Research and Treatment Center, Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, USA
    Thorax 61:507-13. 2006
    WC and NS contributed equally. Non-tuberculous mycobacteria (NTM) frequently colonise patients with end stage cystic fibrosis (CF), but its impact on the course of the disease following lung transplantation is unknown.
  7. ncbi Impact of graft colonization with gram-negative bacteria after lung transplantation on the development of bronchiolitis obliterans syndrome in recipients with cystic fibrosis
    J Gottlieb
    Department of Respiratory Medicine OE6870, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Respir Med 103:743-9. 2009
    Bronchiolitis obliterans syndrome (BOS) represents the leading cause of late mortality after lung transplantation (LTx)...
  8. ncbi Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation
    Jason D Christie
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 24:1454-9. 2005
  9. pmc Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation
    L Fan
    Department of General Surgery, The First Affiliated Hospital, Xi an Jiaotong University School of Medicine, Xi an, China
    Am J Transplant 11:911-22. 2011
    ..In addition, these data indicate that neutralizing IL-17A or augmenting IL-10 could be therapeutic interventions to prevent OB...
  10. ncbi A mouse model of orthotopic vascularized aerated lung transplantation
    M Okazaki
    Division of Cardiothoracic Surgery, Department of Surgery, Washington University in St Louis, St Louis, MO, USA
    Am J Transplant 7:1672-9. 2007
    Outcomes after lung transplantation are markedly inferior to those after other solid organ transplants. A better understanding of cellular and molecular mechanisms contributing to lung graft injury will be critical to improve outcomes...
  11. ncbi A randomised controlled trial of azithromycin to prevent chronic rejection after lung transplantation
    R Vos
    Laboratory of Pneumology, Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 37:164-72. 2011
    ..expiratory volume in 1 s (FEV₁) in chronic rejection or bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx). Azithromycin prophylaxis might prevent BOS...
  12. ncbi Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation
    Frank D'Ovidio
    Toronto Lung Transplant Program, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    J Thorac Cardiovasc Surg 129:1144-52. 2005
    ..Aspiration of gastroesophageal refluxate may contribute to lung transplant bronchiolitis obliterans syndrome (BOS). We investigated bile acids in bronchoalveolar lavage fluid (BALF) and studied its role in BOS...
  13. ncbi Primary graft dysfunction
    James C Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Am Thorac Soc 6:39-46. 2009
    ..form of ischemia/reperfusion acute lung injury that is a major cause of early morbidity and mortality after lung transplantation. Survivors of PGD have worse long-term lung function and an increased chance of developing bronchiolitis ..
  14. ncbi The impact of traffic air pollution on bronchiolitis obliterans syndrome and mortality after lung transplantation
    Tim S Nawrot
    Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
    Thorax 66:748-54. 2011
    Approximately half of all patients who underwent a lung transplantation suffer from bronchiolitis obliterans syndrome (BOS), the clinical correlate of chronic rejection, within 5 years after transplantation...
  15. ncbi Update on donor assessment, resuscitation, and acceptance criteria, including novel techniques--non-heart-beating donor lung retrieval and ex vivo donor lung perfusion
    Jonathan C Yeung
    Toronto Lung Transplant Program, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, Canada
    Thorac Surg Clin 19:261-74. 2009
    The shortage of adequate organ donors remains a great challenge in clinical lung transplantation. With increasing experience in the medical management and surgical technique of lung transplantation, gradual expansion of the criteria for ..
  16. pmc Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation
    Joseph L Bobadilla
    Microbiology and Immunology, Director, Center for Immunobiology, Indiana University School of Medicine, Van Nuys Medical Sciences Building MS224, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    Am J Respir Crit Care Med 177:660-8. 2008
    The pathogenesis of primary graft dysfunction (PGD), a serious complication of lung transplantation, is poorly understood...
  17. ncbi Lung transplantation
    Robert M Kotloff
    University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 184:159-71. 2011
    First performed in 1963, lung transplantation is approaching the half-century mark...
  18. ncbi Immunity, homing and efficacy of allogeneic adoptive immunotherapy for posttransplant lymphoproliferative disorders
    M K Gandhi
    Clinical Immunhaematology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Australia
    Am J Transplant 7:1293-9. 2007
    ..In the third patient, autopsy demonstrated homing of allo-CTL at the tumor site. Larger prospective studies of EBV-specific allo-CTL in PTLD are warranted...
  19. ncbi Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis
    Gabriel Thabut
    Service de Pneumologie et Reanimation Respiratoire, Hopital Beaujon, 100 Avenue du Général Leclerc, 92110 Clichy, France
    J Thorac Cardiovasc Surg 126:469-75. 2003
    Although lung transplantation is viewed as an acceptable option for patients with end-stage idiopathic pulmonary fibrosis, the survival benefit of this approach is still debated...
  20. ncbi Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome
    Sangeeta M Bhorade
    Section of Pulmonary, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Transplantation 90:540-6. 2010
    b>Lung transplantation, in patients with end-stage lung disease, is limited by chronic rejection, which occurs with an incidence and severity exceeding most other transplanted organs...
  21. ncbi Development of the new lung allocation system in the United States
    T M Egan
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Transplant 6:1212-27. 2006
    ....
  22. ncbi Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung
    C Edward Rose
    Division of Pulmunory and Critical Care Medicine and the Division of Rheumatology and Immunology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Microcirculation 10:273-88. 2003
    ....
  23. ncbi Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation
    J G Mainz
    CF Centre, Pediatric Pneumology, Jena University Hospital, Germany
    J Cyst Fibros 11:158-61. 2012
    We report on two CF patients who received double lung transplantation (LTX) due to Pseudomonas aeruginosa related pulmonary destruction. Prior to LTX we detected P. aeruginosa in nasal lavages (NL) and sputum cultures from both patients...
  24. ncbi Posttransplant malignancies in solid organ adult recipients: an analysis of the U.S. National Transplant Database
    Marcelo Santos Sampaio
    Mendez National Institute of Transplantation, Los Angeles, CA 90057, USA
    Transplantation 94:990-8. 2012
    ..De novo posttransplant malignancy (PTM) is a serious complication of transplantation. Incidences may vary among solid organ transplantations (SOTs) and may take to particular screening recommendations and posttransplantation care...
  25. ncbi Telephone-based coping skills training for patients awaiting lung transplantation
    James A Blumenthal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Consult Clin Psychol 74:535-44. 2006
    ..care teaching hospitals, the authors randomly assigned 328 patients with end-stage lung disease awaiting lung transplantation to 12 weeks of telephone-based coping skills training (CST) or to usual medical care (UMC)...
  26. pmc Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat
    Patrick Paulus
    Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 7:e39265. 2012
    ..control lungs. After lung transplantation, the VEGF-A induced reperfusion-edema is significantly lower in Deguelin-treated animals than in controls...
  27. ncbi Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome
    M Paraskeva
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital Melbourne Vic 3181, Australia ANZIC RC
    Am J Transplant 11:2190-6. 2011
    ..CMV) pneumonitis as a risk factor for development of bronchiolitis obliterans syndrome (BOS) following lung transplantation. While improvements in antiviral prophylaxis have resulted in a decreased incidence of CMV pneumonitis, ..
  28. ncbi Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients
    Nicole A Mifsud
    Department of Medicine, Monash University, Central Clinical School, The Alfred Hospital, Melbourne, Victoria, Australia
    Transplantation 90:1439-49. 2010
    ....
  29. ncbi Decreased efferocytosis and mannose binding lectin in the airway in bronchiolitis obliterans syndrome
    Sandra Hodge
    Lung Research Laboratory, Hanson Institute and Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia
    J Heart Lung Transplant 30:589-95. 2011
    ..MBL and efferocytosis in other chronic inflammatory lung diseases; we therefore hypothesized that reduced MBL and efferocytosis in the airways may be a determinant of bronchiolitis obliterans syndrome (BOS) after lung transplantation.
  30. ncbi Natural killer cells and lung transplantation, roles in rejection, infection, and tolerance
    J E Fildes
    The Transplant Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, Southmoor Road, Manchester, M23 9LT, UK
    Transpl Immunol 19:1-11. 2008
    ..organ preservation, immunosuppression, and management of infection, the long term survival following lung transplantation remains low, mainly due to immune mediated complications such as acute and chronic rejection...
  31. ncbi Reverse cardiac remodelling in patients with primary pulmonary hypertension after isolated lung transplantation
    Marie Theres Kasimir
    Department of Cardiothoracic and Vascular Anaesthesia and Intensive Care, Medical University of Vienna, Vienna, Austria
    Eur J Cardiothorac Surg 26:776-81. 2004
    ..The purpose of this study was to prove reverse cardiac remodelling after isolated bilateral lung transplantation (LuTX) in patients with advanced primary pulmonary hypertension (PPH) and severe alterations of cardiac ..
  32. ncbi Long-term azithromycin for bronchiolitis obliterans syndrome after lung transplantation
    Jens Gottlieb
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    Transplantation 85:36-41. 2008
    Bronchiolitis obliterans syndrome (BOS) is a major cause of morbidity and mortality after lung transplantation (LTx). Macrolides are a promising treatment option for BOS...
  33. ncbi A dichotomy in bronchiolitis obliterans syndrome after lung transplantation revealed by azithromycin therapy
    B M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur Respir J 32:832-43. 2008
    Bronchiolitis obliterans syndrome (BOS) is the most important cause of late mortality following lung transplantation, resulting in major morbidity and a huge burden on healthcare resources...
  34. ncbi Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation
    Geert M Verleden
    University Hospital Gasthuisberg, Department of Respiratory Medicine and Lung Transplantation Unit, Leuven, Belgium
    Transplantation 77:1465-7. 2004
    Bronchiolitis obliterans syndrome (BOS) is the leading cause of late mortality after lung transplantation.
  35. ncbi Chronic lung allograft rejection: mechanisms and therapy
    John A Belperio
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Proc Am Thorac Soc 6:108-21. 2009
    b>Lung transplantation is a therapeutic option for patients with end-stage pulmonary disorders. Unfortunately, due to post-lung transplant complications, both infectious and noninfectious, it is only a treatment and not a cure...
  36. ncbi The role of interleukin-17 during acute rejection after lung transplantation
    B M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit, and Lung Transplantation Unit, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 27:779-87. 2006
    Acute rejection (AR) is an important complication that can occur after lung transplantation and constitutes a risk factor for bronchiolitis obliterans syndrome, which is characterised by a neutrophilic airway inflammation...
  37. ncbi Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation
    R Duane Davis
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 125:533-42. 2003
    Bronchiolitis obliterans is the greatest limitation to the long-term applicability of lung transplantation. Although alloimmune events are important, nonimmune events, such as gastroesophageal reflux, might contribute to lung injury and ..
  38. ncbi Pulmonary hemodynamics in advanced COPD candidates for lung volume reduction surgery or lung transplantation
    Gabriel Thabut
    Service de Pneumologie et Reanimation Respiratoire, Hopital Beaujon, 100 B du Général Leclerc 92110, Clichy, France
    Chest 127:1531-6. 2005
    To assess the pulmonary hemodynamic characteristics in COPD candidates for lung volume reduction surgery (LVRS) or lung transplantation (LT).
  39. ncbi The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation
    B M Vanaudenaerde
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Transplant 8:1911-20. 2008
    Bronchiolitis obliterans syndrome (BOS) is the leading cause of death after lung transplantation. Treatment is challenging, as the precise pathophysiology remains unclear...
  40. pmc Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation
    Carolyn S Calfee
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California 94143 0130, USA
    J Heart Lung Transplant 26:675-80. 2007
    ..formerly termed reperfusion pulmonary edema, is the leading cause of short-term complications after lung transplantation. New evidence shows that alveolar type I epithelial cells play an active role in alveolar fluid transport ..
  41. pmc Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects
    Ruiping Song
    Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 163:231-42. 2003
    Successful lung transplantation has been limited by the high incidence of acute graft rejection...
  42. ncbi The phenotype and function of lung dendritic cells
    Tonya J Webb
    Center for Immunobiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Crit Rev Immunol 25:465-91. 2005
    ....
  43. ncbi Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: a randomized, controlled trial
    Scott M Palmer
    Duke University Medical Center and Duke Clinical Research Institute, Durham, NC, USA
    Ann Intern Med 152:761-9. 2010
    Cytomegalovirus (CMV) is the most prevalent opportunistic infection after lung transplantation. Current strategies do not prevent CMV in most at-risk patients.
  44. ncbi The phosphodiesterase type IV inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells in lung transplantation patients
    Des M Murphy
    The Applied Immunobiology and Transplantation Research Group Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom
    J Heart Lung Transplant 25:1436-40. 2006
    Bronchiolitis obliterans syndrome (BOS) remains the major cause of long-term morbidity and mortality after lung transplantation, and new therapeutic measures are needed...
  45. ncbi Should cystic fibrosis patients infected with Burkholderia cepacia complex be listed for lung transplantation?
    Anne Olland
    Strasbourg Lung Transplantation Team, University Hospital, Strasbourg, France
    Interact Cardiovasc Thorac Surg 13:631-4. 2011
    A best evidence topic was constructed according to a structured protocol. The question addressed was whether lung transplantation remained a beneficial treatment for cystic fibrosis (CF) patients infected or colonized with Burkholderia ..
  46. ncbi Randomized trial of a decision aid for patients with cystic fibrosis considering lung transplantation
    Katherine L Vandemheen
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    Am J Respir Crit Care Med 180:761-8. 2009
    We developed an evidence-based decision aid for patients with advanced cystic fibrosis considering referral for lung transplantation.
  47. ncbi Survival of Burkholderia cepacia sepsis following lung transplantation in recipients with cystic fibrosis
    E F Nash
    Toronto Lung Transplant Program, University Health Network, University of Toronto, Canada
    Transpl Infect Dis 12:551-4. 2010
    ..CF) lung transplant recipients infected with Burkholderia cenocepacia have a worse survival rate after lung transplantation than those who are not infected with this organism...
  48. ncbi Outcomes and pulmonary function in living lobar lung transplant donors
    Fengshi Chen
    Department of Thoracic Surgery, Kyoto University, Kyoto, Japan
    Transpl Int 25:153-7. 2012
    Successful living-donor lobar lung transplantation (LDLLT) largely depends on donor outcome; however, there are few studies that have assessed outcomes of LDLLT donors, particularly pulmonary function...
  49. ncbi Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: a single-center experience
    Anthony De Soyza
    Transplantation and Immunobiology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Heart Lung Transplant 29:1395-404. 2010
    ..Therefore, many transplant centers do not list these patients for transplantation...
  50. ncbi CD26/DPP-4 inhibition recruits regenerative stem cells via stromal cell-derived factor-1 and beneficially influences ischaemia-reperfusion injury in mouse lung transplantation
    Wolfgang Jungraithmayr
    Division of Thoracic Surgery, University Hospital, Zurich, Switzerland
    Eur J Cardiothorac Surg 41:1166-73. 2012
    ..Here, we aimed to identify an important substrate of CD26/DPP-4-stromal cell-derived factor-1 (SDF-1/CXCL12)-as a key modulator for stem-cell homing together with its receptor CXCR4 in response to ischaemic injury of the lung...
  51. ncbi Primary lung transplantation after bridge with extracorporeal membrane oxygenation: a plea for a shift in our paradigms for indications
    Gyorgy Lang
    Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Transplantation 93:729-36. 2012
    The introduction of the lung allocation score has brought lung transplantation (LTX) of patients on extracorporeal membrane oxygenation (ECMO) bridge into the focus of interest...
  52. ncbi Indications, patient selection and timing of referral for lung transplantation
    A R Glanville
    The Lung Transplant Unit, St Vincent s Hospital, Sydney, New South Wales, Australia
    Eur Respir J 22:845-52. 2003
    b>Lung transplantation (LTx) is now generally accepted as a useful modality of care for patients with severe life-threatening respiratory diseases that are refractory to other medical or surgical therapies...
  53. pmc Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation
    Patrick Paulus
    Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 8:e73298. 2013
    ..Additionally, prednisolone preconditioning might also lead to macrophage polarization as a beneficial long-term effect. ..
  54. pmc Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre- and post-lung transplantation in the pig
    Jonathan C Yeung
    Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University of Toronto, Toronto, Ontario, Canada
    Mol Ther 20:1204-11. 2012
    ..In summary, ex vivo delivery of adenoviral gene therapy to the donor lung is superior to in vivo delivery in that it leads to less vector-associated inflammation and provides superior post-transplant lung function...
  55. ncbi Simplified rat lung transplantation using a new cuff technique
    Taichiro Goto
    Department of General Thoracic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Ann Thorac Surg 93:2078-80. 2012
    We introduce a new procedure for orthotopic left lung transplantation in rats. First, cuffs are attached to vessels or bronchi in both donors and recipients...
  56. pmc Longitudinal analysis of the lung microbiome in lung transplantation
    Klaudyna Borewicz
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    FEMS Microbiol Lett 339:57-65. 2013
    ..The microbiome of the transplanted lung is vastly different from that of healthy lungs, mainly due to the presence of the family Burkholderiaceae in transplant samples...
  57. pmc Prevalence and clonality of Burkholderia cepacia complex genomovars in UK patients with cystic fibrosis referred for lung transplantation
    A De Soyza
    Transplantation and Immunobiology Group, The Freeman Hospital, High Heaton, Newcastle upon Tyne NE7 7DN, UK
    Thorax 59:526-8. 2004
    It has previously been reported that patients infected with Burkholderia cenocepacia (genomovar III) before lung transplantation have a poorer outcome than those with other B. cepacia complex infections.
  58. pmc Clinical risk factors for primary graft dysfunction after lung transplantation
    Joshua M Diamond
    Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 187:527-34. 2013
    Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors.
  59. ncbi Lung transplantation in patients with cystic fibrosis and Mycobacterium abscessus infection
    Marita Gilljam
    Department of Respiratory Medicine and Allergology, Bruna Stråket 11b, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    J Cyst Fibros 9:272-6. 2010
    ..abscessus lung disease is difficult to treat and has been considered a strong relative contraindication to lung transplantation. We performed double lung transplantation in three cystic fibrosis patients with ongoing, and a fourth with ..
  60. ncbi Post-transplant lymphoproliferative disease in pediatric lung transplant recipients: recent advances in monitoring
    Okan Elidemir
    Department of Pediatrics, Division of Pediatric Pulmonology, Texas Children s Hospital, Houston, TX 77030, USA
    Pediatr Transplant 13:606-10. 2009
    ..05 for all time points). Close monitoring of EBV viral load by qPCR and the degree of immunosuppression via ImmuKnow may guide physicians to reach the diagnosis of PTLD early...
  61. ncbi Technical modification of unilateral lung transplantation in rats
    Pablo Gerardo Sanchez
    Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    J Bras Pneumol 33:448-53. 2007
    ..The model of unilateral left lung transplantation in rats has proven to be a useful alternative for those purposes...
  62. ncbi A targeted peritransplant antifungal strategy for the prevention of invasive fungal disease after lung transplantation: a sequential cohort analysis
    Sophia Koo
    Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Transplantation 94:281-6. 2012
    ..that optimally balances effective reduction of IFD with a minimum of toxicity remains undefined; universal triazole prophylaxis is common at lung transplantation (LT) centers, despite the well-known toxicities and costs of this approach.
  63. ncbi Extended donor criteria for lung transplantation--a clinical reality
    Clemens Aigner
    Department of Cardiothoracic Surgery, Vienna Medical University, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Eur J Cardiothorac Surg 27:757-61. 2005
    ..Since the scarcity of donor organs is one of the major limitations to lung transplantation, extension of donor lung criteria might considerably increase the donor pool...
  64. ncbi Differences in CMV-specific T-cell levels and long-term susceptibility to CMV infection after kidney, heart and lung transplantation
    Urban Sester
    Medical Department IV, University of the Saarland, Homburg, Germany
    Am J Transplant 5:1483-9. 2005
    Patients after kidney, heart and lung transplantation differ in their immunosuppressive drug regimens and in susceptibility to infectious complications with cytomegalovirus (CMV)...
  65. ncbi Medium-term outcome after lung transplantation is comparable between brain-dead and cardiac-dead donors
    Stephanie I De Vleeschauwer
    Laboratory of Pneumology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Heart Lung Transplant 30:975-81. 2011
    Donation after cardiac death (DCD) to overcome the donor organ shortage is now moving into the clinical setting, but the medium-term outcome after DCD lung transplantation (LTx) remains largely unknown.
  66. ncbi Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning
    Bartlomiej Zych
    Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, UK
    J Heart Lung Transplant 31:274-81. 2012
    Ex vivo lung perfusion (EVLP) is a novel approach for extended evaluation and/or reconditioning of donor lungs not meeting standard International Society for Heart and Lung Transplantation criteria for transplantation.
  67. ncbi The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation
    Jurg Hamacher
    Internal Medicine V Pulmonary Division, University Hospital Homburg, Homburg, Germany
    Crit Care Med 38:871-8. 2010
    ..treatment for ischemia reperfusion-mediated lung injury, accompanied by a disrupted barrier integrity and a dysfunctional alveolar liquid clearance, alternative therapies restoring these parameters after lung transplantation are required.
  68. ncbi Nitrite reduces acute lung injury and improves survival in a rat lung transplantation model
    R Sugimoto
    Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Transplant 12:2938-48. 2012
    Ischemia/reperfusion injury (IRI) is the most common cause of early mortality following lung transplantation (LTx). We hypothesized that nitrite, an endogenous source of nitric oxide (NO), may protect lung grafts from IRI...
  69. pmc Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study
    David J Lederer
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Am J Respir Crit Care Med 184:1055-61. 2011
    Obesity has been linked to acute lung injury and is a risk factor for early mortality after lung transplantation.
  70. ncbi Co-expression of endothelin-1 and vascular endothelial growth factor mediates increased vascular permeability in lung grafts before reperfusion
    Shahrokh Taghavi
    Department of Cardiothoracic Surgery, University of Vienna, Vienna, Austria
    J Heart Lung Transplant 21:600-3. 2002
    ..Hypoxia and ET-1 co-upregulate VEGF-A overexpression, therefore temporary VEGF-A antagonism during graft preservation might be of benefit in lung transplantation.
  71. ncbi Antireflux surgery for patients with end-stage lung disease before and after lung transplantation
    W J Gasper
    Department of Surgery, University of California San Francisco, 521 Parnassus Avenue, Room C 341, San Francisco, CA 94143, USA
    Surg Endosc 22:495-500. 2008
    ..This study aimed to report the safety of laparoscopic fundoplication for patients with ESLD and GERD before or after lung transplantation.
  72. pmc CD4+ T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants
    Andrew E Gelman
    Division of Cardiothoracic Surgery, Department of Surgery, Washington University, St Louis, MO 63110, USA
    J Immunol 180:4754-62. 2008
    Acute rejection continues to present a major obstacle to successful lung transplantation. Although CD4(+) T lymphocytes are critical for the rejection of some solid organ grafts, the role of CD4(+) T cells in the rejection of lung ..
  73. pmc Regulatory T cells in lung transplantation--an emerging concept
    David C Neujahr
    Emory University Department of Medicine, Emory University Hospital, Atlanta, GA 30322, USA
    Semin Immunopathol 33:117-27. 2011
    b>Lung transplantation represents an option for patients with a variety of end-stage lung diseases...
  74. ncbi Antireflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation
    Toshitaka Hoppo
    Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA 15232, USA
    Arch Surg 146:1041-7. 2011
    ..GERD may cause obliterative bronchiolitis after lung transplantation (LTx), represented by a decline in forced expiratory volume in 1 second (FEV(1)).
  75. ncbi Concomitant endothelin-1 overexpression in lung transplant donors and recipients predicts primary graft dysfunction
    M Salama
    Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria
    Am J Transplant 10:628-36. 2010
    Primary graft dysfunction (PGD) causes significant morbidity following lung transplantation (LTX). Mortality is high in PGD and therapeutic strategies are limited...
  76. pmc Acute rejection and humoral sensitization in lung transplant recipients
    Tereza Martinu
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Proc Am Thorac Soc 6:54-65. 2009
    ..BOS), a condition of progressive airflow obstruction that limits survival to only 50% at 5 years after lung transplantation. Recent evidence demonstrates that peribronchiolar mononuclear inflammation (also known as lymphocytic ..
  77. ncbi Effects of a telephone-based psychosocial intervention for patients awaiting lung transplantation
    Melissa A Napolitano
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Chest 122:1176-84. 2002
    To test the efficacy of a tailored telephone-based intervention consisting of supportive counseling and cognitive behavioral techniques for individuals awaiting lung transplantation on measures of quality of life and general well-being.
  78. ncbi Graft-protective effects of the HMG-CoA reductase inhibitor pravastatin after lung transplantation--a propensity score analysis with 23 years of follow-up
    Yijiang Li
    Hannover Thoracic Transplant Program, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
    Transplantation 92:486-92. 2011
    To determine whether the hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin has a graft-protective effect, we retrospectively analyzed 502 patients who had undergone lung transplantation in Hannover.
  79. pmc Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction
    J M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Transplant 11:561-7. 2011
    Primary graft dysfunction (PGD) is the leading cause of early posttransplant morbidity and mortality after lung transplantation. Clara cell secretory protein (CC16) is produced by the nonciliated lung epithelium and may serve as a plasma ..
  80. ncbi Recipient vascular endothelial growth factor serum levels predict primary lung graft dysfunction
    K Krenn
    Laboratory for Cardiovascular Research, Center for Anatomy and Cell Biology, Medical University of Vienna, Waehringerstrasse 13, A 1090 Vienna, Austria
    Am J Transplant 7:700-6. 2007
    Primary graft dysfunction (PGD) is a severe complication in lung transplantation. Therapeutic strategies are limited and there exist no predictive markers for PGD...
  81. ncbi Impact of U.S. Lung Allocation Score on survival after lung transplantation
    Christian A Merlo
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Heart Lung Transplant 28:769-75. 2009
    The Lung Allocation Score (LAS) dramatically changed organ allocation in lung transplantation. The impact of this change on patient outcomes is unknown...
  82. ncbi Pulmonary preservation with LPD and celsior solution in porcine lung transplantation after 24 h of cold ischemia
    Sebastian P Sommer
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, 30623 Hannover, Germany
    Eur J Cardiothorac Surg 26:151-7. 2004
    ..The purpose of the study was to compare two extracellular type solutions, low potassium dextrane (LPD) and Celsior in their ability of ameliorating lung ischemia reperfusion injury...
  83. ncbi Twenty-year experience of lung transplantation at a single center: Influence of recipient diagnosis on long-term survival
    Marc de Perrot
    Toronto Lung Transplant Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 127:1493-501. 2004
    The objective of this study was to examine the long-term patient outcomes of lung transplantation in a single center.
  84. pmc Construct validity of the definition of primary graft dysfunction after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 29:1231-9. 2010
    This study tested the discriminant validity of International Society for Heart and Lung Transplantation (ISHLT) primary graft dysfunction (PGD) grades with lung injury biomarker profiles and survival.
  85. ncbi Lung allocation score predicts survival in lung transplantation patients with pulmonary fibrosis
    Eric S Weiss
    Division of Cardiac Surgery, The Johns Hopkins Medical Institution, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 88:1757-64. 2009
    ..and Transplantation Network has used the lung allocation score (LAS) to assign organ allocation priority in lung transplantation. This study was designed to determine whether LAS predicts short-term survival for patients with pulmonary ..
  86. ncbi Severity of lymphocytic bronchiolitis predicts long-term outcome after lung transplantation
    Allan R Glanville
    The Lung Transplant Unit, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Am J Respir Crit Care Med 177:1033-40. 2008
    ..Severe and recurrent acute vascular rejection of the pulmonary allograft is an accepted major risk factor for obliterative bronchiolitis...
  87. ncbi Translational research: animal models of obliterative bronchiolitis after lung transplantation
    M Sato
    Latner Thoracic Research Laboratories, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Transplant 9:1981-7. 2009
    ..bronchiolitis (OB) or chronic graft dysfunction remains the major limitation to long-term success of lung transplantation. Investigation using animal models is a critical component of research to understand the underlying ..
  88. ncbi Impact of lung transplantation on serum lipids in adults with cystic fibrosis
    Edward F Nash
    Toronto Adult Cystic Fibrosis Centre, University Health Network, Toronto, Ontario, Canada
    J Heart Lung Transplant 30:188-93. 2011
    ..that causes progressive respiratory failure and is the third most common indication for adult bilateral lung transplantation. Post-transplant hyperlipidemia commonly affects lung transplant recipients, but the impact of lung ..
  89. pmc CCR2 regulates monocyte recruitment as well as CD4 T1 allorecognition after lung transplantation
    A E Gelman
    Department of Surgery, Washington University in St Louis, St Louis, MO, USA
    Am J Transplant 10:1189-99. 2010
    Graft rejection remains a formidable problem contributing to poor outcomes after lung transplantation. Blocking chemokine pathways have yielded promising results in some organ transplant systems...
  90. ncbi Airway complications and management after lung transplantation: ischemia, dehiscence, and stenosis
    Jose Fernando Santacruz
    Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Proc Am Thorac Soc 6:79-93. 2009
    Overall survival rates of lung transplantation have improved since the first human lung transplantation was performed. A decline in the incidence of airway complications (AC) had been a key feature to achieve the current outcomes...
  91. pmc Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection
    C Agostini
    Department of Clinical and Experimental Medicine, Padua University School of Medicine, Padua, Italy
    Am J Pathol 158:1703-11. 2001
    ....
  92. ncbi A randomized trial of inhaled cyclosporine in lung-transplant recipients
    Aldo T Iacono
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA
    N Engl J Med 354:141-50. 2006
    Conventional regimens of immunosuppressive drugs often do not prevent chronic rejection after lung transplantation. Topical delivery of cyclosporine in addition to conventional systemic immunosuppression might help prevent acute and ..
  93. ncbi A mouse model of orthotopic, single-lung transplantation
    Wolfgang M Jungraithmayr
    Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland
    J Thorac Cardiovasc Surg 137:486-91. 2009
    ..To utilize the breadth of available genetic modifications in a physiologic setup, we optimized and validated a procedure of orthotopically transplanted, perfused, and ventilated single pulmonary transplantation in mice...
  94. pmc Mannose-binding lectin deficiency linked to cytomegalovirus (CMV) reactivation and survival in lung transplantation
    J M Kwakkel-van Erp
    Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Exp Immunol 165:410-6. 2011
    ..influencing T and B cell responses, the prevalence of the bronchiolitis obliterans syndrome (BOS) after lung transplantation is high...
  95. ncbi Health-related quality-of-life determinants in lung transplantation
    Helen Maria Vasiliadis
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    J Heart Lung Transplant 25:226-33. 2006
    In light of recent reviews, we examined the effect of individual and clinical factors, associated with lung transplantation (LTx), on health-related quality of life (HRQL).
  96. ncbi Lung transplantation for pulmonary langerhans' cell histiocytosis: a multicenter analysis
    Gaelle Dauriat
    Division of Pulmonary Medicine, Beaujon Hospital, Clichy, France 2 Division of Pulmonary Medicine, Louis Pradel Hospital, Lyon, France
    Transplantation 81:746-50. 2006
    b>Lung transplantation (LT) may represent a therapeutic option in case of advanced pulmonary Langerhans' cell histiocytosis (PLCH). Little is known however about the characteristics of the patients considered for LT or its results.
  97. ncbi Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD)
    S H K Oertel
    University Medicine of Berlin, Charite Campus Virchow Clinic, Department of Internal Medicine, Berlin, Germany
    Am J Transplant 5:2901-6. 2005
    ..Two patients relapsed, at intervals 3 and 5 months after obtaining complete remission. Rituximab proved to be well tolerated and effective in the treatment of PTLD...
  98. ncbi Lung transplantation in the United States, 1999-2008
    R D Yusen
    Washington University School of Medicine, St Louis, MO, USA
    Am J Transplant 10:1047-68. 2010
    This article highlights trends and changes in lung and heart-lung transplantation in the United States from 1999 to 2008...
  99. ncbi Long-term quality of life in patients surviving at least 55 months after lung transplantation
    Karin M Vermeulen
    Office for Medical Technology Assessment, Groningen University Hospital, The Netherlands
    Gen Hosp Psychiatry 25:95-102. 2003
    The aim of this study was to examine the long-term effect of lung transplantation on Health Related Quality of Life by studying 28 patients who survived at least 55 months after lung transplantation...
  100. pmc The construct validity of the health utilities index mark 3 in assessing health status in lung transplantation
    Maria Jose Santana
    Lung Transplant Program, 2E4, 31 Walter C, Mackenzie Health Sciences Centre, University of Alberta Hospital, Edmonton, T6G2B7, Alberta, Canada
    Health Qual Life Outcomes 8:110. 2010
    To assess the cross-sectional construct validity of the Health Utilities Index Mark 3 (HUI3) in lung transplantation.
  101. ncbi Cystic fibrosis
    Felix Ratjen
    Department of Paediatrics, University of Essen, Essen, Germany
    Lancet 361:681-9. 2003
    ..Here, we summarise advances in understanding and treatment of cystic fibrosis, focusing on pulmonary disease, which accounts for most morbidity and deaths...

Research Grants72

  1. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..R-503, intended for the prevention of lung ischemia-reperfusion injury (LIRI) associated with orthotopic lung transplantation. LIRI results from an acute reperfusion-induced alteration in the synthesis of the free radical superoxide ..
  2. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..injury (IRI) is an acute lung injury that contributes to morbidity and mortality following lung transplantation (LTX)...
  3. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    ..Syndrome (BOS), is the most significant long term cause of morbidity and mortality following human lung transplantation (LTx)...
  4. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..a novel cytoprotective agent (R-801) for the prevention of ischemia-reperfusion injury (IRI) following lung transplantation (LTX)...
  5. Novel Diagnostics to Detect Lung Injury
    Elizabeth R Jacobs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Experts in lung transplantation agree that ischemia is a recognized risk factor for all postlung transplant problems...
  6. Role of TLR-4 in Lung Reperfusion Injury
    MICHAEL SCOTT MULLIGAN; Fiscal Year: 2013
    ..Statement Regarding Relevance to Public Health: Lung transplantation is complicated by the development of tissue injury in the transplanted lung after reconstitution of blood ..
  7. Periostin Regulation of Lung Fibrosis
    Bethany B Moore; Fiscal Year: 2013
    ..Unfortunately, the disease is fatal and there are no effective therapies other than lung transplantation. The most potent profibrotic mediator studied to date is transforming growth factor (TGF) b and TGFb is ..
  8. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis A Ortiz; Fiscal Year: 2012
    ..During the previous cycle of this grant we showed that patients with silicosis have poor response to lung transplantation. We also showed that silica promotes activation of p42 MAPK/ERK and induces phosphorylation of TNFR1, a ..
  9. CTRIP: Molecular phenotypes of rapidly progressive idiopathic pulmonary fibrosis
    Galen B Toews; Fiscal Year: 2010
    ..diagnosis drives overall prognosis and is crucial to selecting the limited available therapies, including lung transplantation. An additional major challenge in the care of IPF patients is determining prognosis...
  10. Effects of lymphangiogenesis stimulation on lung allograft rejection
    Souheil El-Chemaly; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lung transplantation remains the only therapy proven to prolong survival and improve quality of life in advanced lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic ..
  11. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    ..Lung I-R is likely the inciting event leading to acute lung injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema, all of which lead to ..
  12. RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem Cells
    Luis A Ortiz; Fiscal Year: 2013
    ..I clinical trial of MSCs for patients afflicted with progressive IPF who experience severe PAH and for whom lung transplantation in not an option...
  13. The Effects of Lung Transplant on Disability and Health-Related Quality of Life
    Jonathan Paul Singer; Fiscal Year: 2013
    ..goal is to become a successful independent investigator of patient-oriented outcomes in recipients of lung transplantation, specifically disability and health related quality of life (HRQL)...
  14. Obesity, Inflammation, and Lung Injury After Lung Transplantation
    David J Lederer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lung transplantation is a life-saving therapy for adults with advanced lung diseases, such as interstitial lung disease and chronic obstructive pulmonary disease...
  15. The effect of TLR4 inhibition on lung transplant ischemia-reperfusion injury
    PERRY ARTHUR GENOVA; Fiscal Year: 2010
    ..b>Lung transplantation (LTX) has extended and improved the lives of thousands of patients with end-stage lung disease, but is ..
  16. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    b>Lung transplantation (LTX) reduces morbidity and mortality from respiratory failure, but acute and long-term outcomes remain poor...
  17. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lung transplantation is a life-saving option for selected patients with end-stage lung disease...
  18. Role of IL-17 in the Induction of Epithelial to Mesenchymal Transition
    Ragini Vittal; Fiscal Year: 2013
    ..Although lung transplantation is the only definitive therapy for many end stage pulmonary diseases including IPF, chronic rejection (OB) ..
  19. SP-D as an immunomodulatory protein in acute rejection in lung transplantation
    KAREN D SIMS; Fiscal Year: 2010
    b>Lung transplantation has become the standard of care and last therapeutic option for many patients with end-stage lung diseases...
  20. Genome Transplant Dynamics: non-invasive sequencing-based diagnosis of rejection
    HANNAH AUGUSTA contact VALANTINE; Fiscal Year: 2010
    ..AIM 3: Test this approach in lung transplantation and determine whether donor:recipient DNA ratio can differentiate between graft dysfunction due to ..
  21. Novel Cellular Immune Profiles to Predict Lung Disease Outcomes
    Scott M Palmer; Fiscal Year: 2012
    ..application focuses on bronchiolitis obliterans syndrome (BOS), a fibrotic disease that occurs after human lung transplantation and is the primary reason for poor long-term survival among lung transplant recipients...
  22. Role of T Regulatory Cells in Preventing Human BOS
    Aric L Gregson; Fiscal Year: 2013
    ..The research plan is focused on lymphocytes, chemokines, cytokines and long-term graft survival. Lung transplantation is a therapeutic option for end-stage lung disorders...
  23. Telephone-based coping skills training for COPD
    James A Blumenthal; Fiscal Year: 2012
    ..previous work demonstrated that a telephone-based coping skills intervention (CST) with patients awaiting lung transplantation was effective in improving quality of life but did not improve physical functioning or survival...
  24. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lung transplantation (LTx) is a treatment option for end-stage pulmonary parenchymal and vascular diseases...
  25. Circulating biomarkers of IPAH.
    Allen D Everett; Fiscal Year: 2012
    ..of patients do not respond to vasodilators and non-responders have a poor prognosis eventually requiring lung transplantation. As the pathobiology is unknown, vasodilator therapy has significant morbidity and cost and specific ..
  26. Mechanisms and Antigen Identification in a Novel Model of Autoimmune Lung Disease
    Anthony Shum; Fiscal Year: 2013
    ..of systemic autoimmune diseases, often requiring aggressive treatment with high dose immunosuppression or lung transplantation. Despite the significant clinical impact, little is understood about the pathogenesis of lung disease in ..
  27. The Lymphangioleiomyomatosis (LAM)Genome Atlas
    DAVID J contact KWIATKOWSKI; Fiscal Year: 2010
    ..RELEVANCE: Lymphangioleiomyomatosis (LAM) is a rare disease affecting almost exclusively women, for which lung transplantation is the only proven treatment...
  28. INNATE IMMUNE REGULATION OF PRIMARY GRAFT DYSFUNCTION
    Howard J Huang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT ABSTRACT Acute lung injury within 72 hours of lung transplantation, termed Primary Graft Dysfunction (PGD), is a major cause of early post-transplant morbidity and mortality...
  29. TREATMENT OF ANTI-HLA ANTIBODIES TO PREVENT BOS AFTER LUNG TRANSPLANTATION
    Roger D Yusen; Fiscal Year: 2011
    ..or bronchiolitis obliterans syndrome (BOS) has emerged as the primary obstacle to long- term survival after lung transplantation. Though the cause of BOS after lung transplantation remains unclear, identified clinical risk factors ..
  30. Vascular Endothelium Directs the Development of Regulatory T Cells
    Daniel Kreisel; Fiscal Year: 2010
    ..in developing strategies to induce immunological tolerance to solid organ grafts with a particular focus on lung transplantation. Environment: The environment at Washington University in St...
  31. Lung Transplant donor: prediction, evaluation, and mechanism
    Edward Cantu; Fiscal Year: 2013
    ..by applicant): Primary graft dysfunction (PGD) is the most common cause of morbidity and mortality after lung transplantation. Recent data indicate participation of a few specific pathways in acute lung injury models and post-..
  32. Methionine Aminopeptidase 2 in Pulmonary Fibrosis
    DANIEL J KASS; Fiscal Year: 2012
    ..8 years from the onset of symptoms. There are no known effective therapies, except possibly lung transplantation. "Fibroblastic foci," tufts of fibroblasts and myofibroblasts adjacent to injured alveolar epithelium, seen ..
  33. More and Better Lungs: Ex-Vivo Perfusion of Lungs from Non-Heart-Beating Donors
    Thomas M Egan; Fiscal Year: 2013
    ..Lung transplant could improve quality of life and enhance survival in many lung disease patients. However, lung transplantation is severely limited by an inadequate number of suitable lungs for transplant from conventional organ donors ..
  34. Matrix and Bioreactors for Human Lung Regeneration
    Eric S White; Fiscal Year: 2013
    ..Although lung transplantation is a viable alternative for some patients, the 5-year survival rate of approximately 50% (primarily due to ..
  35. Role of anti-Col (V) immunity in primary graft dysfunction
    David S Wilkes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary Graft Dysfunction (PGD) is severe acute lung injury after lung transplantation. PGD has a major impact on outcomes following lung transplantation, markedly increasing morbidity, mortality, and ..
  36. 4D MRI Development for Cardiovascular Imaging
    Jing Liu; Fiscal Year: 2013
    ..inconsistencies and consequent slice-to-slice spatial misregistration, particularly when patients, such as lung transplantation candidates, are unable to perform even a short breath-hold...
  37. RESULT Trial-REflux SUrgery in Lung Transplantation
    Scott M Palmer; Fiscal Year: 2011
    ..This proposal, we have one broad aim, Develop a randomized study, RESULT (Reflux Surgery in Lung Transplantation ) to determine if prevention of GERD related aspiration by surgical fundoplication improves lung allograft ..
  38. Biomimetic Design and Construction of an Artificial Lung
    Jeffrey T Borenstein; Fiscal Year: 2012
    ..no long-term solutions for chronic diseases such as Chronic Obstructive Pulmonary Disease (COPD) other than lung transplantation, and a severe shortage of donor organs limits this approach, leaving most patients relying on home oxygen ..
  39. Matrix Metalloproteinase-8 in Obliterative Bronchiolitis Post Lung Transplant
    Meera Subramaniam; Fiscal Year: 2010
    Obliterative bronchiolitis (OB) is a process of chronic rejection after lung transplantation and is a major challenge for long-term survival...
  40. THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTION
    Daniel Kreisel; Fiscal Year: 2013
    Outcomes after lung transplantation remain significantly worse than after transplantation of other organs...
  41. 2013 LAM Symposium
    FRANCIS XAVIER MCCORMACK; Fiscal Year: 2013
    ..sessions, to address difficult management issues in LAM, including hormonal therapy, air travel, pregnancy, lung transplantation and pleural complications...
  42. Overcoming Barriers to Bioengineering 3-D Human Lung
    Doris A Taylor; Fiscal Year: 2013
    ..Major obstacles to lung transplantation include the paucity of donor lungs available, chronic rejection the requirement for lifelong ..
  43. Use of 3-D Culture and Stretch to Develop Lung from MSCs, ESCs, and iPS
    Daniel J Weiss; Fiscal Year: 2010
    ..the prevalence of this devastating lung disease is increasing worldwide and there remains no cure save for lung transplantation. We propose that novel tissue engineering approaches utilizing embryonic stem cells (ESCs), adult ..
  44. Career Development for Genomic/Genetic Studies in Lung Diseases
    ALLAN IAN PACK; Fiscal Year: 2012
    ..of lung diseases (obstructive sleep apnea, asthma, COPD, interstitial disease, lung cancer, sarcoidosis, lung transplantation) and for many of these diseases there are already DMA samples in a large well characterized patient ..
  45. Subclinical Interstitial Lung Disease in MESA
    David J Lederer; Fiscal Year: 2013
    ..unknown cause that has surpassed chronic obstructive pulmonary disease to become the leading indication for lung transplantation in the United States. No medical therapy has been proven to slow or reverse lung fibrosis...
  46. Indoleamine 2,3-dioxygenase protective role in lung transplantation
    Gary A Visner; Fiscal Year: 2010
    ..goal of this proposal is to improve long-term survival of organ transplants with particular emphasis on lung transplantation. This is particularly relevant to the mission of the agency since 5 year survival (40-50%) of lung ..
  47. T cell-mediated lung ischemia-reperfusion injury
    Victor E Laubach; Fiscal Year: 2013
    ..provided by applicant): Ischemia-reperfusion (IR) injury remains a major source of early mortality after lung transplantation. The objective of this proposal is to better understand the cellular mechanisms that initiate and mediate ..
  48. AMELIORATION OF THE DELETERIOUS EFFECTS OF DONOR BRAIN DEATH
    LUCIA MADARIAGA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The success of lung transplantation in patients with end-stage lung disease has been limited by a high incidence of chronic rejection, which has only been partially ameliorated by the use of ..
  49. A Critical Role for the Microvasculature in Airway Transplantation
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: While lung transplantation is a cure for end-stage pulmonary disease, the majority of patients undergoing this procedure will ..
  50. Compliant Thoracic Artificial Lungs
    KEITH ELLIOT COOK; Fiscal Year: 2012
    ..As a bridge to lung transplantation, a cTAL would allow for more patients to be transplanted and improve outcomes...
  51. High-specificity, non-invasive methods for monitoring lung transplants
    JOHN FREDERIC BEAUSANG; Fiscal Year: 2013
    ..propose to extend this technology, termed the Genome Transplant Dynamics (GTD) method, to the setting of lung transplantation. In this application, dDNA from the lung will be used to detect rejection (Specific Aim #1) and ..
  52. Autologous Lung Multipotent Stromal Cell Therapy for Emphysema
    Edward P Ingenito; Fiscal Year: 2013
    ..2) Initiate Phase 1 trials of autologous LMSC transplantation in emphysema patients awaiting lung transplantation. This trial design will allow us to recover the LMSC-treated organ for histological analysis to ..
  53. EVALUATION OF ENDOBRONCHIAL INTERVENTIONS FOR COPD VIA CT AND 3HE MRI
    Jason C Woods; Fiscal Year: 2011
    ..dyspnea in patients with severe emphysema, for which there is no therapeutic treatment option other than lung transplantation and, for a few, lung volume reduction surgery...
  54. Understanding Barriers to Living Donor Lung Transplantation
    Maryam Valapour; Fiscal Year: 2010
    ..This proposal is designed to: 1) promote Dr. Valapour s development as a scholar in the field of lung transplantation ethics and policymaking by extending her prior training in pulmonary medicine and bioethics, and by adding ..
  55. miR-101 Control of Pulmonary Fibrosis
    Lin Liu; Fiscal Year: 2013
    ..There is no effective therapy except lung transplantation. The pathological hallmark of IPF is the formation of fibroblastic foci consisting of a large number of ..
  56. Treatment of Pulmonary Edema in Organ Donors
    Lorraine B Ware; Fiscal Year: 2012
    ..In response to the barriers to clinical research identified by a recent NHLBI Workshop on lung transplantation, this proposal strives to move the field of clinical lung transplantation forward with a novel, large, ..
  57. Balance of Type 1 and 17 T cell Responses in Airway Rejection: The Role of T-bet
    ELIZABETH ANN LENDERMON; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Lung transplantation is the final therapeutic option for select patients with end-stage lung disease...
  58. Mentored Patient Oriented Research in Lung Transplantation
    Jason D Christie; Fiscal Year: 2013
    ..Dr. Christie's successful research program investigating acute lung injury following lung transplantation (termed primary graft dysfunction, PGD) will be expanded to provide trainees with an intensive research ..
  59. IL-17 and Lung Transplant Obliterative Bronchiolitis
    Rebecca A Shilling; Fiscal Year: 2013
    ..We have now developed a novel mouse model of orthotopic lung transplantation, which unlike other models of lung transplant in rodents, develops reproducible obliteration of the airways ..
  60. Metabolic Reprogramming in LAM: Novel Therapeutic Strategies
    Elizabeth P Henske; Fiscal Year: 2013
    ..in the lungs with cystic destruction of the lung parenchyma, often leading to oxygen-dependency, lung transplantation, and/or death in young adulthood...
  61. Multidisciplinary Training Program in Pediatric Pulmonary
    Pamela L Zeitlin; Fiscal Year: 2013
    ..training in six Research Discipline Groups: (1) lung injury and development;(2) epithelial transport, lung transplantation and cystic fibrosis;(3) sleep disorder;(4) clinical outcomes in pediatric pulmonary diseases;(5) infectious ..
  62. Midcareer Investigator Award in Patient-Oriented Research in Acute Lung Injury
    Lorraine B Ware; Fiscal Year: 2013
    ..Specifically, she will build on studies of organ donors and ALI (primary graft dysfunction, PGD) after lung transplantation, as well as ongoing studies of the mechanistic role of alterations in coagulation and fibrinolysis in ALI...
  63. PATHOPHYSIOLOGY OF ISCHEMIA-REPERFUSION LUNG INJURY
    AUBREY TAYLOR; Fiscal Year: 1992
    ..Ischemia- reperfusion may play an etiological role in acute lung injury following lung transplantation, cardiopulmonary bypass, and removal of thrombotic obstruction of major pulmonary arteries, and may be a ..
  64. NF-kB Inhibition of Lung Ischemia Repurfusion Injury
    Patrick Flood; Fiscal Year: 2009
    ..b>Lung transplantation (LTX) has extended and improved the lives of thousands of patients with end-stage lung disease, but is ..
  65. ISCHEMIA-REPERFUSION INJURY AFTER LUNG TRANSPLANTATION
    Joel Cooper; Fiscal Year: 1991
    A clinical program has been developed that includes single lung transplantation for end-stage pulmonary fibrosis, double lung transplantation for emphysema and crystic fibrosis, and combined lung-heart transplantation for individuals with ..
  66. Modulation of innate immunity in lung transplantation
    Sadis Matalon; Fiscal Year: 2005
    ..and azathioprine in reducing the incidence of acute rejection during the first twelve months after lung transplantation. Infection is a secondary endpoint and is assessed throughout the trial (i.e...
  67. Paracorporeal Artificial Lung Development
    Scott Merz; Fiscal Year: 2001
    ..Verbatim from the Applicant's Abstract): Despite the widespread success and enthusiasm f single and double lung transplantation, demand for donor lungs has steadily outgrown supply...
  68. Molecular Pathogenesis of Cystic Fibrosis Liver Disease
    Martin Carey; Fiscal Year: 2007
    ..cause of morbidity and premature death in CF, and when pulmonary disease is controlled with or without lung transplantation, liver disease is the leading cause of death...
  69. VENTING FOR REDUCTION OF HYPERINFLATION IN EMPHYSEMA
    Joel Cooper; Fiscal Year: 2005
    ..Once medical therapy has been maximized, further therapeutic strategies are limited, apart from lung transplantation, and lung volume reduction surgery, both of which are applicable to only a small subsegment of end-stage ..
  70. Innovative Methods for Immune Tolerance in Lung Transpl*
    David Wilkes; Fiscal Year: 2003
    b>Lung transplantation is the only definitive treatment modality for end stage pulmonary diseases. However, the lung is rejected more frequently than other solid organ allografts...
  71. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2004
    b>Lung transplantation (LTx) is a common treatment option in a variety of end-stage pulmonary Parenchymal and vas diseases...
  72. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..