- Overwhelming postsplenectomy infection: is quality of patient knowledge enough for prevention?
Mohsen Saleh El-Alfy
Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Hematol J 5:77-80. 2004
Fulminant, potentially life-threatening infection represents a major long-term risk after splenectomy. This study examines the impact of patient's knowledge and compliance on the prevention of overwhelming postsplenectomy infection (OPSI).
- Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
Jared M Huston
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
J Exp Med 203:1623-8. 2006
- Single incision laparoscopic splenectomy: the first two cases
Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
J Gastrointest Surg 13:1520-3. 2009
..Herein we report two splenectomy cases where single incision surgery (SILS) technique was performed.
- Infections of people with complement deficiencies and patients who have undergone splenectomy
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 322, 364 Plantation Street, Worcester, MA 01605, USA
Clin Microbiol Rev 23:740-80. 2010
..Paramount to the management of patients with complement deficiencies and asplenia is educating patients about their predisposition to infection and the importance of preventive immunizations and seeking prompt medical attention...
- Single-port access: a feasible alternative to conventional laparoscopic splenectomy
Eduardo M Targarona
Hospital de Sant Pau, Barcelona, Spain
Surg Innov 16:348-52. 2009
The laparoscopic approach has become the gold standard for splenectomy despite the fact that the spleen is a solid organ located deep in the splenic fossa...
- Randomized clinical trial of splenectomy versus splenic preservation in patients with proximal gastric cancer
Department of Surgery, Kyungpook National University, Taegu 700 721, Korea
Br J Surg 93:559-63. 2006
..Preservation or removal of the spleen during total gastrectomy for proximal gastric cancer is a matter of debate...
- Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis
Department of Genetics, Biology and Biochemistry, University of Turin and the San Giovanni Battista Hospital, Turin, Italy
Blood 100:4201-8. 2002
..These data demonstrate that haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis...
- Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen size and donor type
Divisione Ematologia e Trapianto di Midollo Ospedale San Martino, Genova, Italy
Bone Marrow Transplant 45:458-63. 2010
..age and gender, Dupriez score, IPSS (International Prognostic Scoring System) score pre-transplant and splenectomy. In conclusion, PMF patients undergoing an allogeneic HSCT may be scored according to the spleen size, ..
- Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats
Hepatosplenic Surgery Center Department of General Surgery, The First Clinical College, Harbin Medical University, Peking University, Beijing, China
Surgery 141:32-40. 2007
..b>Splenectomy protects organs from intestinal I/R injury...
- Splenic injury: a rare complication of endoscopic retrograde cholangiopancreatography
Nicholas J Zyromski
Department of Surgery, Medical College of Ohio, Toledo, Ohio 43614 5807, USA
Am Surg 70:737-9. 2004
..As ERCP is being employed more frequently for the diagnosis and treatment of pancreatico-biliary disease, clinicians must be aware of this rare but potentially lethal complication to allow for early accurate diagnosis and therapy...
- Wandering spleen with chronic torsion
Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
Am J Surg 195:504-5. 2008
..Owing to the symptomatic splenomegaly with hypersplenism and chronic torsion, laparoscopic splenectomy was performed.
- The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection
J E Locke
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Transplant 7:842-6. 2007
..We review our experience using splenectomy combined with PP/IVIg as rescue therapy for patients experiencing an acute deterioration in renal function and ..
- Memory B cells in common variable immunodeficiency: clinical associations and sex differences
Department of Medicine, Pediatrics and Immunobiology Center, Mount Sinai Medical School, New York, NY 10029, USA
Clin Immunol 128:314-21. 2008
..007) and severe infections (p=0.001). We conclude that outcomes in CVID depend on an interplay of factors including sex, numbers of switched memory B cells, and baseline serum IgG and IgA levels...
- B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen
Department of Developmental Immunology, Max Planck Institute for Immunobiology, Freiburg 79108, Germany
J Exp Med 195:771-80. 2002
Splenectomized individuals are prone to overwhelming infections with encapsulated bacteria and splenectomy of mice increases susceptibility to streptococcal infections, yet the exact mechanism by which the spleen protects against such ..
- Post-splenectomy and hyposplenic states
Antonio Di Sabatino
First Department of Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S Matteo, University of Pavia, Italy
Lancet 378:86-97. 2011
..through vaccination and antibiotic prophylaxis is the basis of the management of patients who have had splenectomy or have hyposplenism...
- A prospective randomized study comparing D2 total gastrectomy versus D2 total gastrectomy plus splenectomy in 187 patients with gastric carcinoma
Department of Surgery, University of Chile Hospital, Santiago, Chile
Surgery 131:401-7. 2002
Classic surgical treatment of upper third gastric carcinoma is based on an extended total gastrectomy, including splenectomy. The purpose of this study was to perform a prospective randomized clinical trial comparing the early and late ..
- Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases
T S Neuhauser
Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC, USA
Mod Pathol 13:978-87. 2000
..The majority of splenic angiosarcomas coexpress histiocytic and endothelial markers by immunohistochemical analysis, which suggest that some tumors may originate from splenic lining cells...
- Palliative goals, patient selection, and perioperative platelet management: outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic
Ruben A Mesa
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer 107:361-70. 2006
Although splenectomy may palliate massive splenomegaly in patients with myelofibrosis with myeloid metaplasia, this procedure carries significant risks...
- Overwhelming infection in asplenic patients: current best practice preventive measures are not being followed
D J Waghorn
Department of Microbiology, Wycombe General Hospital, Buckinghamshire, UK
J Clin Pathol 54:214-8. 2001
..Data including the nature of the infection and vaccination/ antibiotic prophylaxis history since splenectomy were obtained. RESULTS: Seventy seven cases were reported...
- Splenectomy does not offer immunological benefits in ABO-incompatible liver transplantation with a preoperative rituximab
Department of Hepatobiliary Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto, Japan
Transplantation 93:99-105. 2012
..b>Splenectomy, an integral part of protocol for ABO-I LT, decreases anti-ABO antibodies...
- Laparoscopic splenectomy with or without devascularization of the stomach for liver cirrhosis and portal hypertension: a systematic review
Xiao Dong Chen
Department of Hepatobiliary Gastrointestinal Surgery, Sichuan Cancer Hospital and Institute, Chengdu, China
ANZ J Surg 83:122-8. 2013
Open splenectomy and devascularization are effective treatments for cirrhotic patients with severe thrombocytopenia and variceal bleeding...
- Ten years of experience with resection of left-sided pancreatic ductal adenocarcinoma: evolution and initial experience to a laparoscopic approach
Chang Moo Kang
Department of Surgery, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, Korea
Surg Endosc 24:1533-41. 2010
With increasing laparoscopic experience, laparoscopic distal pancreatectomy with or without splenectomy is being regarded as a safe and effective treatment for benign and borderline malignant lesions of the pancreas; however, its ..
- Concomitant laparoscopic splenectomy and cholecystectomy
Department of Surgery, Iwate Medical University School of Medicine, Japan
Surg Laparosc Endosc Percutan Tech 20:66-8. 2010
..The aim of this study was to assess the feasibility and outcomes of concomitant laparoscopic treatment for coexisting spleen and gallbladder diseases...
- Splenectomy changes the pattern of cytokine production in beta-thalassemic patients
Ghollam Reza Moshtaghi-Kashanian
Physiology Research center of Kerman University of Medical Sciences, Kerman, Iran
Cytokine 35:253-7. 2006
- Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins
Steven M Strasberg
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Am Coll Surg 204:244-9. 2007
..We now present results of treatment of patients with adenocarcinoma using RAMPS with particular reference to the ability of this procedure to obtain negative tangential margin rates...
- The effects of splenectomy on lipid peroxidation and neuronal loss in experimental spinal cord ischemia/reperfusion injury
Gulhane Military Medical Academy, Department of Neurosurgery, Ankara, Turkey
Turk Neurosurg 23:67-74. 2013
The aim of this study is to investigate the effects of prior splenectomy on oxidative stress and neuronal loss following spinal cord ischemia and reperfusion injury.
- Immediate splenectomy decreases mortality and improves cognitive function of rats after severe traumatic brain injury
Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China
J Trauma 71:141-7. 2011
..The purpose of this study was to evaluate the significance of the spleen in traumatic brain edema after severe TBI...
- Long-term results of resection of adenocarcinoma of the body and tail of the pancreas using radical antegrade modular pancreatosplenectomy procedure
Jonathan B Mitchem
Section of Hepato Pancreato Biliary Surgery, Washington University in St Louis, St Louis, MO 63110, USA
J Am Coll Surg 214:46-52. 2012
..The purpose of this report is to provide long-term survival results...
- Hemoglobin normalization after splenectomy in a paroxysmal nocturnal hemoglobinuria patient treated by eculizumab
Antonio M Risitano
Blood 112:449-51. 2008
- Pediatric laparoscopic splenectomy: benefits of the anterior approach
P De Lagausie
Department of Pediatric Surgery, Hospital Robert Debre, Paris XIX, France
Surg Endosc 18:80-2. 2004
b>Splenectomy is frequently performed in children for various hematologic and autoimmune disorders. We reviewed our indication for splenectomy, our technique of laparoscopic, splenectomy, and our results...
- Murine models of anaemia of inflammation: extramedullary haematopoiesis represents a species specific difference to human anaemia of inflammation that can be eliminated by splenectomy
T E O Schubert
Department of Pathology, University of Regensburg, Regensburg, Germany
Int J Immunopathol Pharmacol 21:577-84. 2008
..Our results demonstrate that murine AI differs from human AI with respect to increased splenic extramedullary haematopoiesis. Our data demonstrate that induction of AI in splenectomised mice represents a good way to model human AI...
- Portal vein thrombosis after laparoscopic splenectomy: the size of the risk
Eduard M Targarona
Service of General and Digestive Surgery, Hospital de Sant Pau, Autonomous University of Barcelona, Spain
Surg Innov 15:266-70. 2008
Portal vein thrombosis (PVT) after splenectomy is a potentially life-threatening complication. Clinical symptoms may be insidious, and progression can lead to intestinal infarction and portal hypertension...
- Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring
T M Cox
Department of Medicine, University of Cambridge, Addenbrooke s NHS Foundation Hospitals Trust, Cambridge, UK
J Inherit Metab Dis 31:319-36. 2008
..This review makes recommendations related specifically to the management of pregnancy; the appropriate use of splenectomy and bisphosphonate treatment; the relevance of biochemical markers to disease monitoring; and the use of semi-..
- Localized, splenic, diffuse large B-cell lymphoma presenting with hypersplenism: risk and benefit of splenectomy
Department of Internal Medicine, Nihon University School of Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan
Intern Med 49:1027-30. 2010
Herein we report a case of a localized, massive, diffuse large B-cell splenic lymphoma diagnosed by splenectomy. A 57-year-old man complaining of weight loss and abdominal pain, was admitted to our hospital...
- Pre- and postoperative systemic hemodynamic evaluation in patients subjected to esophagogastric devascularization plus splenectomy and distal splenorenal shunt: a comparative study in schistomomal portal hypertension
Roberto de Cleva
Gastroenterology Department, University of Sao Paulo Medical School, Rua Cel Artur Godoy 125, Apto 152 Vila Mariana, Sao Paulo, SP 04018 050, Brazil
World J Gastroenterol 13:5471-5. 2007
..To investigate the systemic hemodynamic effects of two surgical procedures largely employed for treatment of schistosomal portal hypertension...
- Splenectomy leads to a persistent hypercoagulable state after trauma
Jennifer M Watters
Department of Surgery, Division of Trauma, Critical Care and Acute Care Surgery, Oregon Health and Science University, Portland, OR, USA
Am J Surg 199:646-51. 2010
It was hypothesized that splenectomy following trauma results in hypercoagulability.
- Laparoendoscopic single site (LESS) splenectomy with a conventional laparoscope and instruments
Modesto J Colon
Division of General Surgery, Department of Surgery, Mount Sinai School of Medicine, New York, New York, USA
JSLS 15:384-6. 2011
We present 2 cases of laparoendoscopic single site surgery (LESS) splenectomy performed with a conventional laparoscope and instruments, and the use of a novel internal retraction device.
- En-bloc stapling of the splenic hilum in laparoscopic splenectomy
Department of Pediatric Surgery, Ankara University School of Medicine, Ankara, Turkey
Minim Invasive Ther Allied Technol 16:360-2. 2007
..A retrospective chart review was performed of 17 consecutive children undergoing laparoscopic splenectomy between June 2003 and June 2005 by a single surgeon. A routine four-trocar technique was used in all patients...
- Laparoscopic splenectomy with peginterferon and ribavirin therapy for patients with hepatitis C virus cirrhosis and hypersplenism
Department of Surgery, Fukuoka City Hospital, 13 1 of Yoshizukahonmachi, Hakata Ku, Fukuoka 812 0046, Japan
Surg Endosc 24:680-5. 2010
This study aimed to evaluate whether laparoscopic splenectomy (Lap-Sp) contributes to the completion and curability of combined peginterferon and ribavirin (peg-IFN + RIB) therapy for cirrhotic patients with pancytopenia due to ..
- Combined subcutaneous, intrathoracic and abdominal splenosis
Department of Radiology, Tabriz University of Medical Sciences, Imam Reza Hospital, Golbad Ave, Tabriz, East Azerbaijan, Iran
Arch Iran Med 13:436-9. 2010
..The patient's past medical history included a splenectomy due to abdominal trauma and years later, a lung lobectomy due to recurrent pneumonia...
- Splenectomy improves liver function in patients with liver cirrhosis
Clinical Medicine and Biomedical Science, Mie University Graduate School of Medicine, Tsu, Mie, Japan
Hepatogastroenterology 55:1407-11. 2008
Partial splenic embolization or splenectomy has been reported to improve liver function as well as hypersplenism. The aim of this study was to evaluate the effects of splenectomy in patients with liver cirrhosis (LC) on liver function.
- Total gastrectomy with simultaneous pancreaticosplenectomy or splenectomy in patients with advanced gastric carcinoma
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan
Br J Cancer 79:1789-93. 1999
A splenectomy or distal pancreaticosplenectomy is often performed simultaneously with total gastrectomy in the treatment of gastric carcinoma to facilitate dissection of the lymph nodes around the splenic artery and splenic hilus...
- Randomized controlled trial to evaluate splenectomy in total gastrectomy for proximal gastric carcinoma: Japan clinical oncology group study JCOG 0110-MF
Gastric Surgery Division, National Cancer Center Hospital and Cancer Information and Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan
Jpn J Clin Oncol 32:363-4. 2002
A randomized controlled trial has started in Japan to evaluate the role of splenectomy in the surgical management of gastric cancer...
- Laparoscopic partial splenectomy
Department of Surgery, Lehigh Valley Hospital, Penn State University Clinical Campus, 1240 South Cedar Crest Boulevard, Suite 210, Allentown, PA 18103, USA
Surg Endosc 21:57-60. 2007
The immunologic function of the spleen and its important role in immune defense has led to splenic-preserving surgery. This study aimed to evaluate whether laparoscopic partial splenectomy is safe.
- Early experience with single incision laparoscopic surgery: eliminating the scar from abdominal operations
Division of Pediatric Surgery, Department of Surgery, Lucile Packard Children s Hospital, Stanford University Medical Center, Stanford, CA 94305, USA
J Pediatr Surg 44:1741-5. 2009
..The primary goal is to avoid visible scarring. This is the first report of SILS cholecystectomy in children and the first report in the literature of SILS splenectomy.
- Life expectancy in Gaucher disease type 1
Neal J Weinreb
University Research Foundation for Lysosomal Storage Diseases, Northwest Oncology Hematology Associates PA, 8170 Royal Palm Boulevard, Coral Springs, Florida 33065, USA
Am J Hematol 83:896-900. 2008
..Estimated life expectancy at birth for GD1 patients was approximately 9 y less than reference population. Malignancies did not contribute to shortened life expectancy...
- Laparoscopic splenectomy with interferon therapy in 100 hepatitis-C-virus-cirrhotic patients with hypersplenism and thrombocytopenia
Department of Surgery and Science, Kyushu University, Fukuoka, Japan
J Gastroenterol Hepatol 27:286-90. 2012
We intended to determine whether laparoscopic splenectomy (Lap-Sp) contributes to treatment with interferon therapy in hepatitis C virus (HCV)-cirrhotic patients with thrombocytopenia caused by hypersplenism.
- Unusual subcutaneous splenosis occurring in a gunshot wound scar: pathology and immunohistochemical identification
Chi Ju Yeh
Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kwei San, Taoyuan, Taiwan
Pathol Int 56:336-9. 2006
..of subcutaneous splenosis developed in an exit gunshot wound scar on the left lower chest wall 9 years after splenectomy. The lesion presented as an asymptomatic subcutaneous nodule, which was excised under the impression of a skin ..
- Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenism
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Gastroenterol Hepatol 25:397-402. 2010
To evaluate and compare laparoscopic splenectomy and partial splenic embolization as supportive intervention for cirrhotic patients with hypersplenism to overcome peripheral cytopenia before the initiation of and during interferon ..
- [Splenic rupture in infectious disease: splenectomy or conservative treatment? Report of three cases]
Service des Maladies Infectieuses et Tropicales, Hopital d Instruction des armees BEGIN, 69, avenue de Paris, 94160 Saint Mande, France
Rev Med Interne 23:85-91. 2002
Spontaneous splenic ruptures are rare but life-threatening complications of infectious diseases. Splenectomy is still the treatment of choice but numerous recent reports have documented favorable outcome with conservative treatment.
- CT and MRI of intraperitoneal splenosis
Department of Diagnostic and Interventional Radiology, Papageorgiou General Hospital, Thessaloniki, Greece
Diagn Interv Radiol 16:145-9. 2010
..locations due to heterotopic auto-transplantation and implantation of splenic tissue after splenic trauma or splenectomy. It is a benign condition that is often misdiagnosed as a tumor; therefore, knowledge of this condition is ..
- Spleen is a primary site for activation of platelet-reactive T and B cells in patients with immune thrombocytopenic purpura
Institute for Advanced Medical Research and Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
J Immunol 168:3675-82. 2002
..T and B cells were evaluated in the peripheral blood and spleen obtained from nine IMTP patients undergoing splenectomy. There was no difference in gpIIb-IIIa-reactive T cell frequencies between peripheral blood and spleen (6...
- Single incision approach for splenic diseases: a preliminary report on a series of 8 cases
Eduardo M Targarona
Service of Surgery, Hospital de Sant Pau, UAB, Mas Casanovas 90, Barcelona, Spain
Surg Endosc 24:2236-40. 2010
..We describe our initial experience using SILS for the management of splenic diseases...
- Modified radical lymphadenectomy without splenectomy in patients with proximal gastric cancer: comparison with standard D2 lymphadenectomy for distal gastric cancer
Department of Surgery, Chonnam National University College of Medicine, Hwasun Cancer Center, Gwangju, Korea
J Surg Oncol 98:500-4. 2008
We assessed the optimal extent of lymph node dissection and the effect of splenectomy in patients with proximal gastric cancer.
- Single access laparoscopic splenectomy
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
JSLS 13:601-4. 2009
Laparoscopic splenectomy has been performed in a standard fashion with 4 to 5 trocars since the early 1990s. Single access laparoscopy has recently gained interest, but single access laparoscopic splenectomy has not been reported to date...
- Single port access (SPA) splenectomy
Steven J Rottman
Drexel University College of Medicine, Department of Surgery, Philadelphia, Pennsylvania, USA
JSLS 14:48-52. 2010
Over the last decade, laparoscopic splenectomy has become the standard of care for spleen removal. Elimination of a large incision and difficult exposure has decreased postoperative morbidity and length of stay...
- An audit of post-splenectomy prophylaxis--are we following the guidelines?
Department of General Medicine, Salisbury District Hospital, Salisbury, Wiltshire, UK
Ann R Coll Surg Engl 85:252-5. 2003
..g. Streptococcus pneumoniae). This is an audit to look at a district general hospital's compliance with published guidelines for immunisations and antibiotic prophylaxis post-splenectomy.
- Effectiveness and safety of splenectomy for gastric carcinoma: a meta-analysis
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, China
World J Gastroenterol 15:5352-9. 2009
To evaluate the impact of splenectomy on long-term survival, postoperative morbidity and mortality of patients with gastric cancer by performing a meta-analysis.
- Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation
Department of Pediatrics, Geneva University Hospital, Geneva, Switzerland
Blood 111:439-45. 2008
..Infectious complications (6%) related to splenectomy were also significant and may warrant a more restrictive approach to performing splenectomy in WAS patients...
- Timing of initiation of enzyme replacement therapy after diagnosis of type 1 Gaucher disease: effect on incidence of avascular necrosis
Pramod K Mistry
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
Br J Haematol 147:561-70. 2009
..The adjusted incidence rate ratio was 0.59 [95% confidence interval (CI) 0.36-0.96, P = 0.0343]. Splenectomy was an independent risk factor for AVN (adjusted incidence rate ratio 2.23, 95% CI 1.61-3.08, P < 0.0001)...
- Perioperative outcomes of laparoscopic versus open splenectomy: a meta-analysis with an emphasis on complications
Emily R Winslow
Department of Surgery, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
Surgery 134:647-53; discussion 654-5. 2003
The purpose of this study was to analyze the published perioperative results of laparoscopic splenectomy (LS) compared to open splenectomy (OS), and to determine the impact of LS on the incidence and type of splenectomy-related ..
- Role of the spleen in peripheral memory B-cell homeostasis in patients with autoimmune thrombocytopenia purpura
Charité Center 14 for Tumor Medicine, Institute for Transfusion Medicine and Immune Hematology, Charite University Hospital, Berlin, Germany
Clin Immunol 130:199-212. 2009
The effect of splenectomy on circulating memory B cells in autoimmune thrombocytopenia purpura (AITP) patients has not yet been addressed...
- Laparoscopic splenectomy: the clinical practice guidelines of the European Association for Endoscopic Surgery (EAES)
Institute for Research in Operative Medicine, University Witten Herdecke, Witten Herdecke, IFOM, Ostmerheimer Strasse 200, 51109, Koln, Germany
Surg Endosc 22:821-48. 2008
Although laparoscopic splenectomy (LS) has become the standard approach for most splenectomy cases, some areas still remain controversial. To date, the indications that preclude laparoscopic splenectomy are not clearly defined...
- Clinical manifestation of beta-thalassemia/hemoglobin E disease
Thalassemia Research Center, Institute of Science and Technology for Research and Development, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Puttamonthon, Nakornpathorm, Thailand
J Pediatr Hematol Oncol 22:552-7. 2000
..To review the clinical manifestation and changes in hematologic parameters of patients with beta-thalassemia/hemoglobin (Hb) E...
- Splenectomy in proximal gastric cancer: frequency of lymph node metastasis to the splenic hilus
S P Mönig
Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
J Surg Oncol 76:89-92. 2001
The indication for splenectomy in proximal gastric cancer remains controversial. Splenectomy is performed because of possible lymph node metastasis of the splenic hilus or infiltration/metastasis of the spleen...
- Splenectomy and sepsis: the role of the spleen in the immune-mediated bacterial clearance
Department of Internal Medicine, Immunology and Infectious Diseases, Castellana Grotte, Bari, Italy
Immunopharmacol Immunotoxicol 23:153-61. 2001
Over the past few years, many observations of overwhelming post splenectomy bacterial infections have been reported...
- Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors
Jeffrey A Norton
Department of Surgery, University of California, San Francisco, CA 94143, USA
Arch Surg 138:859-66. 2003
..Aggressive surgery remains a potentially efficacious antitumor therapy but is rarely performed because of its possible morbidity and mortality...
- Splenectomy and thrombosis: the case of thalassemia intermedia
A T Taher
Department of Internal Medicine, Hematology Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon
J Thromb Haemost 8:2152-8. 2010
..However, clinical and laboratory characteristics of patients who eventually develop overt thromboembolic events (TEE) are poorly studied...
- Single-center experience of laparoscopic left pancreatic resection in 359 consecutive patients: changing the surgical paradigm of left pancreatic resection
Ki Byung Song
Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Songpa Ku, Seoul, South Korea
Surg Endosc 25:3364-72. 2011
..We analyzed the clinical characteristics of the largest series of patients to date who underwent LDP at a single center, as well as their outcomes, to reassess the surgical paradigm for left pancreatic resection...
- Osseous manifestations of adult Gaucher disease in the era of enzyme replacement therapy
Patrick B Deegan
Lysosomal Disorders Unit, Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom patrick deegan addenbrookes nhs uk
Medicine (Baltimore) 90:52-60. 2011
..Osteonecrosis was associated with age of presentation and with splenectomy-indeed, we observed a strong temporal association between splenectomy and incidence of osteonecrosis...
- Delayed growth and puberty in patients with Gaucher disease type 1: natural history and effect of splenectomy and/or enzyme replacement therapy
Institute of Endocrinology and Diabetes, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
Isr Med Assoc J 2:158-63. 2000
..Growth retardation in childhood was only recently recognized as a prominent feature of Gaucher disease type 1, but there are few data on both the pubertal development and the final outcome of growth and sexual maturation...
- Severe hepatosplenic schistosomiasis: clinicopathologic study of 102 cases undergoing splenectomy
Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Centre for Research and Control on Schistosomiasis on Lake Region, Yueyang, Hunan Province 414000, The People s Republic of China
Hum Pathol 42:111-9. 2011
We present the preoperative findings of 102 patients who underwent successful splenectomy for advanced schistosomiasis japonica...
- Successful rescue of refractory, severe antibody mediated rejection with splenectomy
Division of Transplant Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Transplantation 83:99-100. 2007
..We report a case series of four patients with AMR refractory to standard therapy (ST) who resolved after splenectomy. Four living donor kidney transplant recipients were diagnosed with AMR...
- Solitary splenic metastasis of an adenocarcinoma of the lung 2 years postoperatively
I Van Hul
Department of General Surgery, Sint Vincentiusziekenhuis, Antwerp, Belgium
Acta Chir Belg 108:462-3. 2008
..Most patients with splenic metastases have widely disseminated metastatic disease. We report a case of an asymptomatic, isolated splenic metastasis in a 67-year-old man diagnosed 2 years after resection of an adenocarcinoma of the lung...
- Preconditioning regimen consisting of anti-CD20 monoclonal antibody infusions, splenectomy and DFPP-enabled non-responders to undergo ABO-incompatible kidney transplantation
Second Department of Surgery, Dokkyo University School of Medicine, Tochigi, Japan
Clin Transplant 18:254-60. 2004
..we developed a new preconditioning regimen consisting of anti-CD20 monoclonal antibody (rituximab) infusions, a splenectomy, and DFPP...
- Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
Soon Tae Lee
Stroke and Stem Cell Laboratory, Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
Brain 131:616-29. 2008
..To investigate whether NSCs interact with spleen to reduce cerebral inflammation, we performed a splenectomy prior to ICH induction, which eliminated the effect of NSCs-iv-2 h transplantation on brain water content and ..
- Plasmodium berghei: parasite clearance after treatment with dihydroartemisinin in an asplenic murine malaria model
Brioni R Moore
School of Pharmacy, Curtin University of Technology, P O Box U1987, Perth, WA 6845, Australia
Exp Parasitol 118:458-67. 2008
..The asplenic murine malaria model could be used in pre-clinical studies of splenic function and clearance of malaria parasites, pathophysiological studies or antimalarial drug efficacy in asplenia...
- Laparoscopic splenectomy for massive splenomegaly
Kent W Kercher
Department of General Surgery, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232, USA
Am J Surg 183:192-6. 2002
Laparoscopic splenectomy (LS) is the preferred operative approach for diseases involving normal-sized spleens. Our experience with laparoscopic splenectomy in the setting of massive splenomegaly is presented.
- Report of the Spanish Gaucher's disease registry: clinical and genetic characteristics
Servicio de Hematologia y Hemoterapia, Hospital Universitario Miguel Servet, P masculine Isabel La Católica 1 3, 50009 Zaragoza, Spain
Haematologica 85:792-9. 2000
..Some statistical analyses of these data are reported concerning the distribution, clinical and genetic characteristics of GD in Spain and the response to enzyme replacement therapy (ERT) is evaluated...
- Splenectomy for immune thrombocytopenic purpura: long-term results and treatment of postsplenectomy relapses
Division of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Ann Hematol 81:312-9. 2002
Information regarding prognostic determinants of outcome after splenectomy for adult immune thrombocytopenic purpura (ITP) and the management of postsplenectomy relapse is limited...
- Reactivation versus primary CMV infection after splenectomy in immunocompetent patients
Sieff Government Hospital Liver Unit, Safed, Israel
Dig Dis Sci 52:3477-9. 2007
..We present a case of CMV infection in a previously healthy man who just had splenectomy for blunt trauma: a short incubation of the CMV disease, a strongly positive CMV antigenemia, severity of the ..
- Overwhelming postsplenectomy infection syndrome in adults - a clinically preventable disease
Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi 783 8505, Japan
World J Gastroenterol 14:176-9. 2008
..However, recognition and clinical management of OPSI is not well established. The prevalence of splenectomy increased recently because it was a clinically effective treatment for hepatitis C virus-associated ..
- ABO incompatible high-titer renal transplantation without splenectomy or anti-CD20 treatment
Dorry L Segev
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Transplant 5:2570-5. 2005
Most successful protocols for renal transplantation across ABO incompatible (ABOi) barriers have utilized splenectomy as part of the pre-conditioning process...
- Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature
M de Fost
Department of Endocrinology and Metabolism, F4 279, University of Amsterdam, Academic Medical Center, P O Box 22700, 1100 DD Amsterdam, The Netherlands
Ann Hematol 87:439-49. 2008
..A beneficial effect of ERT on the occurrence and progression of gammopathies was suggested from longitudinal data...
- Portal vein thrombosis after laparoscopic and open splenectomy
Department of Surgery, University of Catania, Catania, Italy
J Laparoendosc Adv Surg Tech A 21:71-5. 2011
Portal vein thrombosis (PVT) could be a life-threatening complication after splenectomy if not diagnosed promptly and treated properly. Risk factors of PVT are not completely clarified...
- Indication of splenectomy for gastric carcinoma involving the proximal part of the stomach
First Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, 634-8522, Japan
Hepatogastroenterology 48:603-5. 2001
BACKGROUND/AIMS: The role of splenectomy in the surgical management of gastric carcinoma is controversial and there is no consensus of opinion regarding the therapeutic value of splenectomy...
- Laparoscopic splenectomy for the treatment of wandering spleen
A O Monaldi, Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione, U O C di Chirurgia Generale, Naples, Italy
Surg Endosc 18:554-6. 2004
..A case of wandering spleen treated with laparoscopic splenectomy is described and compared with other similar reports in the literature...
- On the mechanism of post-splenectomy leukocytosis in mice
Tel Aviv University, Tel Aviv, Hadassah University Hospital, Jerusalem, Israel
Eur J Clin Invest 33:811-7. 2003
..Increased number of peripheral white blood cells (PWBCs) has been noted after removal of the spleen...
- Functional, life-threatening disorders and splenectomy following liver transplantation
Department of General, Abdominal and Transplant Surgery, University of Gent, Belgium
Clin Transplant 13:380-8. 1999
b>Splenectomy (SPL) in cirrhotic patients undergoing liver transplantation (LTx) may resolve specific problems related to the procedure itself, in case of functional and life-threatening clinical situations often occurring as a result of ..
- Splenectomy and chronic thromboembolic pulmonary hypertension
UPRES EA 2705, Centre des Maladies Vasculaires Pulmonaires, Service de Pneumologie et Reanimation Respiratoire, Hopital Antoine Beclere, 157 rue de la Porte de Trivaux, 92140 Clamart, France
Thorax 60:1031-4. 2005
An increased prevalence of splenectomy has been reported in patients with idiopathic pulmonary arterial hypertension...
- Rituximab before splenectomy in adults with primary idiopathic thrombocytopenic purpura: a meta-analysis
Haematology Department, University Hospital Saint Eloi, Montpellier, France
Br J Haematol 158:386-98. 2012
..Corticosteroids are the standard initial treatment. Splenectomy is the main second-line treatment...
- Bolus versus continuous fluid resuscitation and splenectomy for treatment of uncontrolled hemorrhagic shock after massive splenic injury
Michael M Krausz
Department of Surgery, Rambam Medical Center, Haifa, Israel
J Trauma 55:62-8. 2003
..hemorrhagic shock induced by massive splenic injury (MSI), we compared bolus infusion of Ringer's lactate (RL) and hypertonic saline (HTS), combined with splenectomy, to continuous infusion of these solutions and splenectomy in rats.
- Dapsone, danazol, and intrapartum splenectomy in refractory ITP complicating pregnancy
Obstetrics and Gynecology Unit 1, Christian Medical College, Ida Scudder Road, Vellore, India
Indian J Med Sci 62:452-5. 2008
..Our patient with chronic ITP complicating pregnancy, who was refractory to steroids, dapsone, and danazol, was treated successfully with intrapartum splenectomy.
- Laparoscopic splenectomy for autoimmune hemolytic anemia in patients with chronic lymphocytic leukemia: a case series and review of the literature
Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Hematol 75:134-8. 2004
The purpose of this study was to evaluate the safety and efficacy of laparoscopic splenectomy in patients with chronic lymphocytic leukemia (CLL) complicated by autoimmune hemolytic anemia...
- The significance of inadvertent splenectomy during colorectal cancer resection
Marcia L McGory
Center for Surgical Outcomes and Quality, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 72 215 Center for Health Sciences, Los Angeles, CA 90095 6904, USA
Arch Surg 142:668-74. 2007
To examine the frequency, predictors, and outcomes following inadvertent splenectomy during colorectal cancer resection.
- Upper abdominal surgical procedures: liver mobilization and diaphragm peritonectomy/resection, splenectomy, and distal pancreatectomy
Siobhan M Kehoe
Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Gynecol Oncol 111:S51-5. 2008
..A comprehensive approach to surgical cytoreduction, which has been associated with improved survival in patients with advanced ovarian cancer, should incorporate upper abdominal resection...
- Successful rescue of refractory acute antibody-mediated renal allograft rejection with splenectomy--a case report
Pediatric Nephrology and Transplantation Transplant Surgery, Saint Barnabas Medical Center, Livingston, NJ 07039, USA
Pediatr Transplant 16:E49-52. 2012
..He failed to respond to standard therapy and needed an urgent splenectomy as rescue therapy...
- Delayed traumatic diaphragmatic hernia after open splenectomy: report of a case
Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
Surg Today 38:352-4. 2008
..man experienced sudden chest pain radiating into his left shoulder about 16 months after undergoing an open splenectomy for malignant splenic lymphoma...
- Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels
Jared M Huston
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
J Immunol 181:3535-9. 2008
..In this study, we report that splenectomy significantly reduces systemic HMGB1 release and improves survival in mice with polymicrobial sepsis...
- Laparoscopic splenectomy with the da Vinci robot
Department of General and Transplant Surgery, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
J Laparoendosc Adv Surg Tech A 15:1-5. 2005
..We report our first series of minimally invasive splenectomies with a robotic surgical system...
- Hospital experience, body image, and cosmesis after laparoscopic or open splenectomy
Aras Emre Canda
Department of Surgery, Manisa State Hospital, Manisa, Turkey
Surg Laparosc Endosc Percutan Tech 19:479-83. 2009
Laparoscopic splenectomy (LS) is becoming the "gold standard" technique for splenectomy. The aim of this study was to evaluate the hospital experience, body image, and cosmesis after LS or open splenectomy (OS).