splenectomy

Summary

Top Publications

  1. ncbi Overwhelming postsplenectomy infection: is quality of patient knowledge enough for prevention?
    Mohsen Saleh El-Alfy
    Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Hematol J 5:77-80. 2004
  2. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
  3. ncbi Single incision laparoscopic splenectomy: the first two cases
    Umut Barbaros
    Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
    J Gastrointest Surg 13:1520-3. 2009
  4. pmc Infections of people with complement deficiencies and patients who have undergone splenectomy
    Sanjay Ram
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 322, 364 Plantation Street, Worcester, MA 01605, USA
    Clin Microbiol Rev 23:740-80. 2010
  5. ncbi Single-port access: a feasible alternative to conventional laparoscopic splenectomy
    Eduardo M Targarona
    Hospital de Sant Pau, Barcelona, Spain
    Surg Innov 16:348-52. 2009
  6. ncbi Randomized clinical trial of splenectomy versus splenic preservation in patients with proximal gastric cancer
    W Yu
    Department of Surgery, Kyungpook National University, Taegu 700 721, Korea
    Br J Surg 93:559-63. 2006
  7. ncbi Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis
    Emanuela Tolosano
    Department of Genetics, Biology and Biochemistry, University of Turin and the San Giovanni Battista Hospital, Turin, Italy
    Blood 100:4201-8. 2002
  8. ncbi Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen size and donor type
    A Bacigalupo
    Divisione Ematologia e Trapianto di Midollo Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 45:458-63. 2010
  9. ncbi Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats
    Hongchi Jiang
    Hepatosplenic Surgery Center Department of General Surgery, The First Clinical College, Harbin Medical University, Peking University, Beijing, China
    Surgery 141:32-40. 2007
  10. ncbi Splenic injury: a rare complication of endoscopic retrograde cholangiopancreatography
    Nicholas J Zyromski
    Department of Surgery, Medical College of Ohio, Toledo, Ohio 43614 5807, USA
    Am Surg 70:737-9. 2004

Research Grants

  1. Sex differences in brain inflammation in experimental stroke
    Halina Offner; Fiscal Year: 2013
  2. Determining Optimum Medical Therapy for ITP
    JAMES BRUCE BUSSEL; Fiscal Year: 2013
  3. Pharmacology and Bioengineering of New Treatment of ITP
    Joseph P Balthasar; Fiscal Year: 2010
  4. The role of CD36 in ischemic inflammation and injury
    Sunghee Cho; Fiscal Year: 2013
  5. Mixed Chimerism in Haploidentical Non-human Primates
    Bernhard Hering; Fiscal Year: 2006
  6. PRECLINICAL BRIDGE TO HUMAN TRANSPLANT TOLERANCE
    Judith Thomas; Fiscal Year: 2000
  7. T CELL ADHESION MOLECULES IN MURINE LUPUS PNEUMONITIS
    Jeffrey Curtis; Fiscal Year: 2002
  8. B Cell Repertoire and B cell Neoplasms in Old Mice
    MARC WEKSLER; Fiscal Year: 2006
  9. COOPERATIVE STUDY OF POLYCYTHEMIA VERA
    Louis Wasserman; Fiscal Year: 1980
  10. MODELS OF THROMBOCYTOPENIA PATHOLOGY & TREATMENT
    Steven McKenzie; Fiscal Year: 2002

Detail Information

Publications342 found, 100 shown here

  1. ncbi Overwhelming postsplenectomy infection: is quality of patient knowledge enough for prevention?
    Mohsen Saleh El-Alfy
    Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Hematol J 5:77-80. 2004
    Fulminant, potentially life-threatening infection represents a major long-term risk after splenectomy. This study examines the impact of patient's knowledge and compliance on the prevention of overwhelming postsplenectomy infection (OPSI).
  2. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ....
  3. ncbi Single incision laparoscopic splenectomy: the first two cases
    Umut Barbaros
    Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
    J Gastrointest Surg 13:1520-3. 2009
    ..Herein we report two splenectomy cases where single incision surgery (SILS) technique was performed.
  4. pmc Infections of people with complement deficiencies and patients who have undergone splenectomy
    Sanjay Ram
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 322, 364 Plantation Street, Worcester, MA 01605, USA
    Clin Microbiol Rev 23:740-80. 2010
    ..Paramount to the management of patients with complement deficiencies and asplenia is educating patients about their predisposition to infection and the importance of preventive immunizations and seeking prompt medical attention...
  5. ncbi Single-port access: a feasible alternative to conventional laparoscopic splenectomy
    Eduardo M Targarona
    Hospital de Sant Pau, Barcelona, Spain
    Surg Innov 16:348-52. 2009
    The laparoscopic approach has become the gold standard for splenectomy despite the fact that the spleen is a solid organ located deep in the splenic fossa...
  6. ncbi Randomized clinical trial of splenectomy versus splenic preservation in patients with proximal gastric cancer
    W Yu
    Department of Surgery, Kyungpook National University, Taegu 700 721, Korea
    Br J Surg 93:559-63. 2006
    ..Preservation or removal of the spleen during total gastrectomy for proximal gastric cancer is a matter of debate...
  7. ncbi Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis
    Emanuela Tolosano
    Department of Genetics, Biology and Biochemistry, University of Turin and the San Giovanni Battista Hospital, Turin, Italy
    Blood 100:4201-8. 2002
    ..These data demonstrate that haptoglobin and hemopexin together are essential for protection from splenomegaly and liver fibrosis resulting from intravascular hemolysis...
  8. ncbi Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen size and donor type
    A Bacigalupo
    Divisione Ematologia e Trapianto di Midollo Ospedale San Martino, Genova, Italy
    Bone Marrow Transplant 45:458-63. 2010
    ..age and gender, Dupriez score, IPSS (International Prognostic Scoring System) score pre-transplant and splenectomy. In conclusion, PMF patients undergoing an allogeneic HSCT may be scored according to the spleen size, ..
  9. ncbi Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats
    Hongchi Jiang
    Hepatosplenic Surgery Center Department of General Surgery, The First Clinical College, Harbin Medical University, Peking University, Beijing, China
    Surgery 141:32-40. 2007
    ..b>Splenectomy protects organs from intestinal I/R injury...
  10. ncbi Splenic injury: a rare complication of endoscopic retrograde cholangiopancreatography
    Nicholas J Zyromski
    Department of Surgery, Medical College of Ohio, Toledo, Ohio 43614 5807, USA
    Am Surg 70:737-9. 2004
    ..As ERCP is being employed more frequently for the diagnosis and treatment of pancreatico-biliary disease, clinicians must be aware of this rare but potentially lethal complication to allow for early accurate diagnosis and therapy...
  11. ncbi Wandering spleen with chronic torsion
    Takeyuki Misawa
    Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Am J Surg 195:504-5. 2008
    ..Owing to the symptomatic splenomegaly with hypersplenism and chronic torsion, laparoscopic splenectomy was performed.
  12. ncbi The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection
    J E Locke
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 7:842-6. 2007
    ..We review our experience using splenectomy combined with PP/IVIg as rescue therapy for patients experiencing an acute deterioration in renal function and ..
  13. pmc Memory B cells in common variable immunodeficiency: clinical associations and sex differences
    Silvia Sánchez-Ramón
    Department of Medicine, Pediatrics and Immunobiology Center, Mount Sinai Medical School, New York, NY 10029, USA
    Clin Immunol 128:314-21. 2008
    ..007) and severe infections (p=0.001). We conclude that outcomes in CVID depend on an interplay of factors including sex, numbers of switched memory B cells, and baseline serum IgG and IgA levels...
  14. pmc B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen
    Hedda Wardemann
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Freiburg 79108, Germany
    J Exp Med 195:771-80. 2002
    Splenectomized individuals are prone to overwhelming infections with encapsulated bacteria and splenectomy of mice increases susceptibility to streptococcal infections, yet the exact mechanism by which the spleen protects against such ..
  15. ncbi Post-splenectomy and hyposplenic states
    Antonio Di Sabatino
    First Department of Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S Matteo, University of Pavia, Italy
    Lancet 378:86-97. 2011
    ..through vaccination and antibiotic prophylaxis is the basis of the management of patients who have had splenectomy or have hyposplenism...
  16. ncbi A prospective randomized study comparing D2 total gastrectomy versus D2 total gastrectomy plus splenectomy in 187 patients with gastric carcinoma
    Attila Csendes
    Department of Surgery, University of Chile Hospital, Santiago, Chile
    Surgery 131:401-7. 2002
    Classic surgical treatment of upper third gastric carcinoma is based on an extended total gastrectomy, including splenectomy. The purpose of this study was to perform a prospective randomized clinical trial comparing the early and late ..
  17. ncbi Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases
    T S Neuhauser
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Mod Pathol 13:978-87. 2000
    ..The majority of splenic angiosarcomas coexpress histiocytic and endothelial markers by immunohistochemical analysis, which suggest that some tumors may originate from splenic lining cells...
  18. ncbi Palliative goals, patient selection, and perioperative platelet management: outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic
    Ruben A Mesa
    Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 107:361-70. 2006
    Although splenectomy may palliate massive splenomegaly in patients with myelofibrosis with myeloid metaplasia, this procedure carries significant risks...
  19. pmc Overwhelming infection in asplenic patients: current best practice preventive measures are not being followed
    D J Waghorn
    Department of Microbiology, Wycombe General Hospital, Buckinghamshire, UK
    J Clin Pathol 54:214-8. 2001
    ..Data including the nature of the infection and vaccination/ antibiotic prophylaxis history since splenectomy were obtained. RESULTS: Seventy seven cases were reported...
  20. ncbi Splenectomy does not offer immunological benefits in ABO-incompatible liver transplantation with a preoperative rituximab
    Vikram Raut
    Department of Hepatobiliary Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo ku, Kyoto, Japan
    Transplantation 93:99-105. 2012
    ..b>Splenectomy, an integral part of protocol for ABO-I LT, decreases anti-ABO antibodies...
  21. ncbi Laparoscopic splenectomy with or without devascularization of the stomach for liver cirrhosis and portal hypertension: a systematic review
    Xiao Dong Chen
    Department of Hepatobiliary Gastrointestinal Surgery, Sichuan Cancer Hospital and Institute, Chengdu, China
    ANZ J Surg 83:122-8. 2013
    Open splenectomy and devascularization are effective treatments for cirrhotic patients with severe thrombocytopenia and variceal bleeding...
  22. ncbi Ten years of experience with resection of left-sided pancreatic ductal adenocarcinoma: evolution and initial experience to a laparoscopic approach
    Chang Moo Kang
    Department of Surgery, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, Korea
    Surg Endosc 24:1533-41. 2010
    With increasing laparoscopic experience, laparoscopic distal pancreatectomy with or without splenectomy is being regarded as a safe and effective treatment for benign and borderline malignant lesions of the pancreas; however, its ..
  23. ncbi Concomitant laparoscopic splenectomy and cholecystectomy
    Akira Sasaki
    Department of Surgery, Iwate Medical University School of Medicine, Japan
    Surg Laparosc Endosc Percutan Tech 20:66-8. 2010
    ..The aim of this study was to assess the feasibility and outcomes of concomitant laparoscopic treatment for coexisting spleen and gallbladder diseases...
  24. ncbi Splenectomy changes the pattern of cytokine production in beta-thalassemic patients
    Ghollam Reza Moshtaghi-Kashanian
    Physiology Research center of Kerman University of Medical Sciences, Kerman, Iran
    Cytokine 35:253-7. 2006
    ....
  25. ncbi Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins
    Steven M Strasberg
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 204:244-9. 2007
    ..We now present results of treatment of patients with adenocarcinoma using RAMPS with particular reference to the ability of this procedure to obtain negative tangential margin rates...
  26. ncbi The effects of splenectomy on lipid peroxidation and neuronal loss in experimental spinal cord ischemia/reperfusion injury
    Caglar Temiz
    Gulhane Military Medical Academy, Department of Neurosurgery, Ankara, Turkey
    Turk Neurosurg 23:67-74. 2013
    The aim of this study is to investigate the effects of prior splenectomy on oxidative stress and neuronal loss following spinal cord ischemia and reperfusion injury.
  27. ncbi Immediate splenectomy decreases mortality and improves cognitive function of rats after severe traumatic brain injury
    Mei Li
    Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China
    J Trauma 71:141-7. 2011
    ..The purpose of this study was to evaluate the significance of the spleen in traumatic brain edema after severe TBI...
  28. ncbi Long-term results of resection of adenocarcinoma of the body and tail of the pancreas using radical antegrade modular pancreatosplenectomy procedure
    Jonathan B Mitchem
    Section of Hepato Pancreato Biliary Surgery, Washington University in St Louis, St Louis, MO 63110, USA
    J Am Coll Surg 214:46-52. 2012
    ..The purpose of this report is to provide long-term survival results...
  29. doi Hemoglobin normalization after splenectomy in a paroxysmal nocturnal hemoglobinuria patient treated by eculizumab
    Antonio M Risitano
    Blood 112:449-51. 2008
  30. ncbi Pediatric laparoscopic splenectomy: benefits of the anterior approach
    P De Lagausie
    Department of Pediatric Surgery, Hospital Robert Debre, Paris XIX, France
    Surg Endosc 18:80-2. 2004
    b>Splenectomy is frequently performed in children for various hematologic and autoimmune disorders. We reviewed our indication for splenectomy, our technique of laparoscopic, splenectomy, and our results...
  31. ncbi Murine models of anaemia of inflammation: extramedullary haematopoiesis represents a species specific difference to human anaemia of inflammation that can be eliminated by splenectomy
    T E O Schubert
    Department of Pathology, University of Regensburg, Regensburg, Germany
    Int J Immunopathol Pharmacol 21:577-84. 2008
    ..Our results demonstrate that murine AI differs from human AI with respect to increased splenic extramedullary haematopoiesis. Our data demonstrate that induction of AI in splenectomised mice represents a good way to model human AI...
  32. ncbi Portal vein thrombosis after laparoscopic splenectomy: the size of the risk
    Eduard M Targarona
    Service of General and Digestive Surgery, Hospital de Sant Pau, Autonomous University of Barcelona, Spain
    Surg Innov 15:266-70. 2008
    Portal vein thrombosis (PVT) after splenectomy is a potentially life-threatening complication. Clinical symptoms may be insidious, and progression can lead to intestinal infarction and portal hypertension...
  33. ncbi Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring
    T M Cox
    Department of Medicine, University of Cambridge, Addenbrooke s NHS Foundation Hospitals Trust, Cambridge, UK
    J Inherit Metab Dis 31:319-36. 2008
    ..This review makes recommendations related specifically to the management of pregnancy; the appropriate use of splenectomy and bisphosphonate treatment; the relevance of biochemical markers to disease monitoring; and the use of semi-..
  34. ncbi Localized, splenic, diffuse large B-cell lymphoma presenting with hypersplenism: risk and benefit of splenectomy
    Noriyoshi Iriyama
    Department of Internal Medicine, Nihon University School of Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan
    Intern Med 49:1027-30. 2010
    Herein we report a case of a localized, massive, diffuse large B-cell splenic lymphoma diagnosed by splenectomy. A 57-year-old man complaining of weight loss and abdominal pain, was admitted to our hospital...
  35. pmc Pre- and postoperative systemic hemodynamic evaluation in patients subjected to esophagogastric devascularization plus splenectomy and distal splenorenal shunt: a comparative study in schistomomal portal hypertension
    Roberto de Cleva
    Gastroenterology Department, University of Sao Paulo Medical School, Rua Cel Artur Godoy 125, Apto 152 Vila Mariana, Sao Paulo, SP 04018 050, Brazil
    World J Gastroenterol 13:5471-5. 2007
    ..To investigate the systemic hemodynamic effects of two surgical procedures largely employed for treatment of schistosomal portal hypertension...
  36. ncbi Splenectomy leads to a persistent hypercoagulable state after trauma
    Jennifer M Watters
    Department of Surgery, Division of Trauma, Critical Care and Acute Care Surgery, Oregon Health and Science University, Portland, OR, USA
    Am J Surg 199:646-51. 2010
    It was hypothesized that splenectomy following trauma results in hypercoagulability.
  37. pmc Laparoendoscopic single site (LESS) splenectomy with a conventional laparoscope and instruments
    Modesto J Colon
    Division of General Surgery, Department of Surgery, Mount Sinai School of Medicine, New York, New York, USA
    JSLS 15:384-6. 2011
    We present 2 cases of laparoendoscopic single site surgery (LESS) splenectomy performed with a conventional laparoscope and instruments, and the use of a novel internal retraction device.
  38. ncbi En-bloc stapling of the splenic hilum in laparoscopic splenectomy
    Rahsan Vargun
    Department of Pediatric Surgery, Ankara University School of Medicine, Ankara, Turkey
    Minim Invasive Ther Allied Technol 16:360-2. 2007
    ..A retrospective chart review was performed of 17 consecutive children undergoing laparoscopic splenectomy between June 2003 and June 2005 by a single surgeon. A routine four-trocar technique was used in all patients...
  39. ncbi Laparoscopic splenectomy with peginterferon and ribavirin therapy for patients with hepatitis C virus cirrhosis and hypersplenism
    Tomohiko Akahoshi
    Department of Surgery, Fukuoka City Hospital, 13 1 of Yoshizukahonmachi, Hakata Ku, Fukuoka 812 0046, Japan
    Surg Endosc 24:680-5. 2010
    This study aimed to evaluate whether laparoscopic splenectomy (Lap-Sp) contributes to the completion and curability of combined peginterferon and ribavirin (peg-IFN + RIB) therapy for cirrhotic patients with pancytopenia due to ..
  40. ncbi Combined subcutaneous, intrathoracic and abdominal splenosis
    Reza Javadrashid
    Department of Radiology, Tabriz University of Medical Sciences, Imam Reza Hospital, Golbad Ave, Tabriz, East Azerbaijan, Iran
    Arch Iran Med 13:436-9. 2010
    ..The patient's past medical history included a splenectomy due to abdominal trauma and years later, a lung lobectomy due to recurrent pneumonia...
  41. ncbi Splenectomy improves liver function in patients with liver cirrhosis
    Kazumoto Murata
    Clinical Medicine and Biomedical Science, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Hepatogastroenterology 55:1407-11. 2008
    Partial splenic embolization or splenectomy has been reported to improve liver function as well as hypersplenism. The aim of this study was to evaluate the effects of splenectomy in patients with liver cirrhosis (LC) on liver function.
  42. pmc Total gastrectomy with simultaneous pancreaticosplenectomy or splenectomy in patients with advanced gastric carcinoma
    E Otsuji
    First Department of Surgery, Kyoto Prefectural University of Medicine, Japan
    Br J Cancer 79:1789-93. 1999
    A splenectomy or distal pancreaticosplenectomy is often performed simultaneously with total gastrectomy in the treatment of gastric carcinoma to facilitate dissection of the lymph nodes around the splenic artery and splenic hilus...
  43. ncbi Randomized controlled trial to evaluate splenectomy in total gastrectomy for proximal gastric carcinoma: Japan clinical oncology group study JCOG 0110-MF
    Takeshi Sano
    Gastric Surgery Division, National Cancer Center Hospital and Cancer Information and Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan
    Jpn J Clin Oncol 32:363-4. 2002
    A randomized controlled trial has started in Japan to evaluate the role of splenectomy in the surgical management of gastric cancer...
  44. ncbi Laparoscopic partial splenectomy
    S Uranues
    Department of Surgery, Lehigh Valley Hospital, Penn State University Clinical Campus, 1240 South Cedar Crest Boulevard, Suite 210, Allentown, PA 18103, USA
    Surg Endosc 21:57-60. 2007
    The immunologic function of the spleen and its important role in immune defense has led to splenic-preserving surgery. This study aimed to evaluate whether laparoscopic partial splenectomy is safe.
  45. ncbi Early experience with single incision laparoscopic surgery: eliminating the scar from abdominal operations
    Sanjeev Dutta
    Division of Pediatric Surgery, Department of Surgery, Lucile Packard Children s Hospital, Stanford University Medical Center, Stanford, CA 94305, USA
    J Pediatr Surg 44:1741-5. 2009
    ..The primary goal is to avoid visible scarring. This is the first report of SILS cholecystectomy in children and the first report in the literature of SILS splenectomy.
  46. pmc Life expectancy in Gaucher disease type 1
    Neal J Weinreb
    University Research Foundation for Lysosomal Storage Diseases, Northwest Oncology Hematology Associates PA, 8170 Royal Palm Boulevard, Coral Springs, Florida 33065, USA
    Am J Hematol 83:896-900. 2008
    ..Estimated life expectancy at birth for GD1 patients was approximately 9 y less than reference population. Malignancies did not contribute to shortened life expectancy...
  47. ncbi Laparoscopic splenectomy with interferon therapy in 100 hepatitis-C-virus-cirrhotic patients with hypersplenism and thrombocytopenia
    Tomohiko Akahoshi
    Department of Surgery and Science, Kyushu University, Fukuoka, Japan
    J Gastroenterol Hepatol 27:286-90. 2012
    We intended to determine whether laparoscopic splenectomy (Lap-Sp) contributes to treatment with interferon therapy in hepatitis C virus (HCV)-cirrhotic patients with thrombocytopenia caused by hypersplenism.
  48. ncbi Unusual subcutaneous splenosis occurring in a gunshot wound scar: pathology and immunohistochemical identification
    Chi Ju Yeh
    Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kwei San, Taoyuan, Taiwan
    Pathol Int 56:336-9. 2006
    ..of subcutaneous splenosis developed in an exit gunshot wound scar on the left lower chest wall 9 years after splenectomy. The lesion presented as an asymptomatic subcutaneous nodule, which was excised under the impression of a skin ..
  49. ncbi Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenism
    Morimasa Tomikawa
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Gastroenterol Hepatol 25:397-402. 2010
    To evaluate and compare laparoscopic splenectomy and partial splenic embolization as supportive intervention for cirrhotic patients with hypersplenism to overcome peripheral cytopenia before the initiation of and during interferon ..
  50. ncbi [Splenic rupture in infectious disease: splenectomy or conservative treatment? Report of three cases]
    C Rapp
    Service des Maladies Infectieuses et Tropicales, Hopital d Instruction des armees BEGIN, 69, avenue de Paris, 94160 Saint Mande, France
    Rev Med Interne 23:85-91. 2002
    Spontaneous splenic ruptures are rare but life-threatening complications of infectious diseases. Splenectomy is still the treatment of choice but numerous recent reports have documented favorable outcome with conservative treatment.
  51. ncbi CT and MRI of intraperitoneal splenosis
    Ioannis Tsitouridis
    Department of Diagnostic and Interventional Radiology, Papageorgiou General Hospital, Thessaloniki, Greece
    Diagn Interv Radiol 16:145-9. 2010
    ..locations due to heterotopic auto-transplantation and implantation of splenic tissue after splenic trauma or splenectomy. It is a benign condition that is often misdiagnosed as a tumor; therefore, knowledge of this condition is ..
  52. ncbi Spleen is a primary site for activation of platelet-reactive T and B cells in patients with immune thrombocytopenic purpura
    Masataka Kuwana
    Institute for Advanced Medical Research and Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Immunol 168:3675-82. 2002
    ..T and B cells were evaluated in the peripheral blood and spleen obtained from nine IMTP patients undergoing splenectomy. There was no difference in gpIIb-IIIa-reactive T cell frequencies between peripheral blood and spleen (6...
  53. ncbi Single incision approach for splenic diseases: a preliminary report on a series of 8 cases
    Eduardo M Targarona
    Service of Surgery, Hospital de Sant Pau, UAB, Mas Casanovas 90, Barcelona, Spain
    Surg Endosc 24:2236-40. 2010
    ..We describe our initial experience using SILS for the management of splenic diseases...
  54. ncbi Modified radical lymphadenectomy without splenectomy in patients with proximal gastric cancer: comparison with standard D2 lymphadenectomy for distal gastric cancer
    Oh Cheong
    Department of Surgery, Chonnam National University College of Medicine, Hwasun Cancer Center, Gwangju, Korea
    J Surg Oncol 98:500-4. 2008
    We assessed the optimal extent of lymph node dissection and the effect of splenectomy in patients with proximal gastric cancer.
  55. pmc Single access laparoscopic splenectomy
    Preeti Malladi
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    JSLS 13:601-4. 2009
    Laparoscopic splenectomy has been performed in a standard fashion with 4 to 5 trocars since the early 1990s. Single access laparoscopy has recently gained interest, but single access laparoscopic splenectomy has not been reported to date...
  56. pmc Single port access (SPA) splenectomy
    Steven J Rottman
    Drexel University College of Medicine, Department of Surgery, Philadelphia, Pennsylvania, USA
    JSLS 14:48-52. 2010
    Over the last decade, laparoscopic splenectomy has become the standard of care for spleen removal. Elimination of a large incision and difficult exposure has decreased postoperative morbidity and length of stay...
  57. pmc An audit of post-splenectomy prophylaxis--are we following the guidelines?
    Jyothi Ramachandra
    Department of General Medicine, Salisbury District Hospital, Salisbury, Wiltshire, UK
    Ann R Coll Surg Engl 85:252-5. 2003
    ..g. Streptococcus pneumoniae). This is an audit to look at a district general hospital's compliance with published guidelines for immunisations and antibiotic prophylaxis post-splenectomy.
  58. pmc Effectiveness and safety of splenectomy for gastric carcinoma: a meta-analysis
    Kun Yang
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 15:5352-9. 2009
    To evaluate the impact of splenectomy on long-term survival, postoperative morbidity and mortality of patients with gastric cancer by performing a meta-analysis.
  59. ncbi Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation
    Hulya Ozsahin
    Department of Pediatrics, Geneva University Hospital, Geneva, Switzerland
    Blood 111:439-45. 2008
    ..Infectious complications (6%) related to splenectomy were also significant and may warrant a more restrictive approach to performing splenectomy in WAS patients...
  60. pmc Timing of initiation of enzyme replacement therapy after diagnosis of type 1 Gaucher disease: effect on incidence of avascular necrosis
    Pramod K Mistry
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Br J Haematol 147:561-70. 2009
    ..The adjusted incidence rate ratio was 0.59 [95% confidence interval (CI) 0.36-0.96, P = 0.0343]. Splenectomy was an independent risk factor for AVN (adjusted incidence rate ratio 2.23, 95% CI 1.61-3.08, P < 0.0001)...
  61. ncbi Perioperative outcomes of laparoscopic versus open splenectomy: a meta-analysis with an emphasis on complications
    Emily R Winslow
    Department of Surgery, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Surgery 134:647-53; discussion 654-5. 2003
    The purpose of this study was to analyze the published perioperative results of laparoscopic splenectomy (LS) compared to open splenectomy (OS), and to determine the impact of LS on the incidence and type of splenectomy-related ..
  62. ncbi Role of the spleen in peripheral memory B-cell homeostasis in patients with autoimmune thrombocytopenia purpura
    Lorena Martinez-Gamboa
    Charité Center 14 for Tumor Medicine, Institute for Transfusion Medicine and Immune Hematology, Charite University Hospital, Berlin, Germany
    Clin Immunol 130:199-212. 2009
    The effect of splenectomy on circulating memory B cells in autoimmune thrombocytopenia purpura (AITP) patients has not yet been addressed...
  63. ncbi Laparoscopic splenectomy: the clinical practice guidelines of the European Association for Endoscopic Surgery (EAES)
    B Habermalz
    Institute for Research in Operative Medicine, University Witten Herdecke, Witten Herdecke, IFOM, Ostmerheimer Strasse 200, 51109, Koln, Germany
    Surg Endosc 22:821-48. 2008
    Although laparoscopic splenectomy (LS) has become the standard approach for most splenectomy cases, some areas still remain controversial. To date, the indications that preclude laparoscopic splenectomy are not clearly defined...
  64. ncbi Clinical manifestation of beta-thalassemia/hemoglobin E disease
    S Fucharoen
    Thalassemia Research Center, Institute of Science and Technology for Research and Development, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Puttamonthon, Nakornpathorm, Thailand
    J Pediatr Hematol Oncol 22:552-7. 2000
    ..To review the clinical manifestation and changes in hematologic parameters of patients with beta-thalassemia/hemoglobin (Hb) E...
  65. ncbi Splenectomy in proximal gastric cancer: frequency of lymph node metastasis to the splenic hilus
    S P Mönig
    Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
    J Surg Oncol 76:89-92. 2001
    The indication for splenectomy in proximal gastric cancer remains controversial. Splenectomy is performed because of possible lymph node metastasis of the splenic hilus or infiltration/metastasis of the spleen...
  66. ncbi Splenectomy and sepsis: the role of the spleen in the immune-mediated bacterial clearance
    M Altamura
    Department of Internal Medicine, Immunology and Infectious Diseases, Castellana Grotte, Bari, Italy
    Immunopharmacol Immunotoxicol 23:153-61. 2001
    Over the past few years, many observations of overwhelming post splenectomy bacterial infections have been reported...
  67. ncbi Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors
    Jeffrey A Norton
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    Arch Surg 138:859-66. 2003
    ..Aggressive surgery remains a potentially efficacious antitumor therapy but is rarely performed because of its possible morbidity and mortality...
  68. ncbi Splenectomy and thrombosis: the case of thalassemia intermedia
    A T Taher
    Department of Internal Medicine, Hematology Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon
    J Thromb Haemost 8:2152-8. 2010
    ..However, clinical and laboratory characteristics of patients who eventually develop overt thromboembolic events (TEE) are poorly studied...
  69. ncbi Single-center experience of laparoscopic left pancreatic resection in 359 consecutive patients: changing the surgical paradigm of left pancreatic resection
    Ki Byung Song
    Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Songpa Ku, Seoul, South Korea
    Surg Endosc 25:3364-72. 2011
    ..We analyzed the clinical characteristics of the largest series of patients to date who underwent LDP at a single center, as well as their outcomes, to reassess the surgical paradigm for left pancreatic resection...
  70. ncbi Osseous manifestations of adult Gaucher disease in the era of enzyme replacement therapy
    Patrick B Deegan
    Lysosomal Disorders Unit, Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom patrick deegan addenbrookes nhs uk
    Medicine (Baltimore) 90:52-60. 2011
    ..Osteonecrosis was associated with age of presentation and with splenectomy-indeed, we observed a strong temporal association between splenectomy and incidence of osteonecrosis...
  71. ncbi Delayed growth and puberty in patients with Gaucher disease type 1: natural history and effect of splenectomy and/or enzyme replacement therapy
    R Kauli
    Institute of Endocrinology and Diabetes, Schneider Children s Medical Center of Israel, Petah Tiqva, Israel
    Isr Med Assoc J 2:158-63. 2000
    ..Growth retardation in childhood was only recently recognized as a prominent feature of Gaucher disease type 1, but there are few data on both the pubertal development and the final outcome of growth and sexual maturation...
  72. ncbi Severe hepatosplenic schistosomiasis: clinicopathologic study of 102 cases undergoing splenectomy
    Yuesheng Li
    Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Centre for Research and Control on Schistosomiasis on Lake Region, Yueyang, Hunan Province 414000, The People s Republic of China
    Hum Pathol 42:111-9. 2011
    We present the preoperative findings of 102 patients who underwent successful splenectomy for advanced schistosomiasis japonica...
  73. ncbi Successful rescue of refractory, severe antibody mediated rejection with splenectomy
    Bruce Kaplan
    Division of Transplant Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Transplantation 83:99-100. 2007
    ..We report a case series of four patients with AMR refractory to standard therapy (ST) who resolved after splenectomy. Four living donor kidney transplant recipients were diagnosed with AMR...
  74. ncbi Solitary splenic metastasis of an adenocarcinoma of the lung 2 years postoperatively
    I Van Hul
    Department of General Surgery, Sint Vincentiusziekenhuis, Antwerp, Belgium
    Acta Chir Belg 108:462-3. 2008
    ..Most patients with splenic metastases have widely disseminated metastatic disease. We report a case of an asymptomatic, isolated splenic metastasis in a 67-year-old man diagnosed 2 years after resection of an adenocarcinoma of the lung...
  75. ncbi Preconditioning regimen consisting of anti-CD20 monoclonal antibody infusions, splenectomy and DFPP-enabled non-responders to undergo ABO-incompatible kidney transplantation
    Tokihiko Sawada
    Second Department of Surgery, Dokkyo University School of Medicine, Tochigi, Japan
    Clin Transplant 18:254-60. 2004
    ..we developed a new preconditioning regimen consisting of anti-CD20 monoclonal antibody (rituximab) infusions, a splenectomy, and DFPP...
  76. ncbi Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
    Soon Tae Lee
    Stroke and Stem Cell Laboratory, Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
    Brain 131:616-29. 2008
    ..To investigate whether NSCs interact with spleen to reduce cerebral inflammation, we performed a splenectomy prior to ICH induction, which eliminated the effect of NSCs-iv-2 h transplantation on brain water content and ..
  77. ncbi Plasmodium berghei: parasite clearance after treatment with dihydroartemisinin in an asplenic murine malaria model
    Brioni R Moore
    School of Pharmacy, Curtin University of Technology, P O Box U1987, Perth, WA 6845, Australia
    Exp Parasitol 118:458-67. 2008
    ..The asplenic murine malaria model could be used in pre-clinical studies of splenic function and clearance of malaria parasites, pathophysiological studies or antimalarial drug efficacy in asplenia...
  78. ncbi Laparoscopic splenectomy for massive splenomegaly
    Kent W Kercher
    Department of General Surgery, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232, USA
    Am J Surg 183:192-6. 2002
    Laparoscopic splenectomy (LS) is the preferred operative approach for diseases involving normal-sized spleens. Our experience with laparoscopic splenectomy in the setting of massive splenomegaly is presented.
  79. ncbi Report of the Spanish Gaucher's disease registry: clinical and genetic characteristics
    P Giraldo
    Servicio de Hematologia y Hemoterapia, Hospital Universitario Miguel Servet, P masculine Isabel La Católica 1 3, 50009 Zaragoza, Spain
    Haematologica 85:792-9. 2000
    ..Some statistical analyses of these data are reported concerning the distribution, clinical and genetic characteristics of GD in Spain and the response to enzyme replacement therapy (ERT) is evaluated...
  80. ncbi Splenectomy for immune thrombocytopenic purpura: long-term results and treatment of postsplenectomy relapses
    S Kumar
    Division of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Ann Hematol 81:312-9. 2002
    Information regarding prognostic determinants of outcome after splenectomy for adult immune thrombocytopenic purpura (ITP) and the management of postsplenectomy relapse is limited...
  81. ncbi Reactivation versus primary CMV infection after splenectomy in immunocompetent patients
    N Assy
    Sieff Government Hospital Liver Unit, Safed, Israel
    Dig Dis Sci 52:3477-9. 2007
    ..We present a case of CMV infection in a previously healthy man who just had splenectomy for blunt trauma: a short incubation of the CMV disease, a strongly positive CMV antigenemia, severity of the ..
  82. pmc Overwhelming postsplenectomy infection syndrome in adults - a clinically preventable disease
    Takehiro Okabayashi
    Department of Surgery, Kochi Medical School, Kohasu Okocho, Nankoku City, Kochi 783 8505, Japan
    World J Gastroenterol 14:176-9. 2008
    ..However, recognition and clinical management of OPSI is not well established. The prevalence of splenectomy increased recently because it was a clinically effective treatment for hepatitis C virus-associated ..
  83. ncbi ABO incompatible high-titer renal transplantation without splenectomy or anti-CD20 treatment
    Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Transplant 5:2570-5. 2005
    Most successful protocols for renal transplantation across ABO incompatible (ABOi) barriers have utilized splenectomy as part of the pre-conditioning process...
  84. pmc Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature
    M de Fost
    Department of Endocrinology and Metabolism, F4 279, University of Amsterdam, Academic Medical Center, P O Box 22700, 1100 DD Amsterdam, The Netherlands
    Ann Hematol 87:439-49. 2008
    ..A beneficial effect of ERT on the occurrence and progression of gammopathies was suggested from longitudinal data...
  85. ncbi Portal vein thrombosis after laparoscopic and open splenectomy
    Rosario Vecchio
    Department of Surgery, University of Catania, Catania, Italy
    J Laparoendosc Adv Surg Tech A 21:71-5. 2011
    Portal vein thrombosis (PVT) could be a life-threatening complication after splenectomy if not diagnosed promptly and treated properly. Risk factors of PVT are not completely clarified...
  86. ncbi Indication of splenectomy for gastric carcinoma involving the proximal part of the stomach
    T Sakaguchi
    First Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, 634-8522, Japan
    Hepatogastroenterology 48:603-5. 2001
    BACKGROUND/AIMS: The role of splenectomy in the surgical management of gastric carcinoma is controversial and there is no consensus of opinion regarding the therapeutic value of splenectomy...
  87. ncbi Laparoscopic splenectomy for the treatment of wandering spleen
    F Corcione
    A O Monaldi, Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione, U O C di Chirurgia Generale, Naples, Italy
    Surg Endosc 18:554-6. 2004
    ..A case of wandering spleen treated with laparoscopic splenectomy is described and compared with other similar reports in the literature...
  88. ncbi On the mechanism of post-splenectomy leukocytosis in mice
    M Djaldetti
    Tel Aviv University, Tel Aviv, Hadassah University Hospital, Jerusalem, Israel
    Eur J Clin Invest 33:811-7. 2003
    ..Increased number of peripheral white blood cells (PWBCs) has been noted after removal of the spleen...
  89. ncbi Functional, life-threatening disorders and splenectomy following liver transplantation
    R Troisi
    Department of General, Abdominal and Transplant Surgery, University of Gent, Belgium
    Clin Transplant 13:380-8. 1999
    b>Splenectomy (SPL) in cirrhotic patients undergoing liver transplantation (LTx) may resolve specific problems related to the procedure itself, in case of functional and life-threatening clinical situations often occurring as a result of ..
  90. pmc Splenectomy and chronic thromboembolic pulmonary hypertension
    X Jais
    UPRES EA 2705, Centre des Maladies Vasculaires Pulmonaires, Service de Pneumologie et Reanimation Respiratoire, Hopital Antoine Beclere, 157 rue de la Porte de Trivaux, 92140 Clamart, France
    Thorax 60:1031-4. 2005
    An increased prevalence of splenectomy has been reported in patients with idiopathic pulmonary arterial hypertension...
  91. ncbi Rituximab before splenectomy in adults with primary idiopathic thrombocytopenic purpura: a meta-analysis
    Sophie Auger
    Haematology Department, University Hospital Saint Eloi, Montpellier, France
    Br J Haematol 158:386-98. 2012
    ..Corticosteroids are the standard initial treatment. Splenectomy is the main second-line treatment...
  92. ncbi Bolus versus continuous fluid resuscitation and splenectomy for treatment of uncontrolled hemorrhagic shock after massive splenic injury
    Michael M Krausz
    Department of Surgery, Rambam Medical Center, Haifa, Israel
    J Trauma 55:62-8. 2003
    ..hemorrhagic shock induced by massive splenic injury (MSI), we compared bolus infusion of Ringer's lactate (RL) and hypertonic saline (HTS), combined with splenectomy, to continuous infusion of these solutions and splenectomy in rats.
  93. ncbi Dapsone, danazol, and intrapartum splenectomy in refractory ITP complicating pregnancy
    Lilly Varghese
    Obstetrics and Gynecology Unit 1, Christian Medical College, Ida Scudder Road, Vellore, India
    Indian J Med Sci 62:452-5. 2008
    ..Our patient with chronic ITP complicating pregnancy, who was refractory to steroids, dapsone, and danazol, was treated successfully with intrapartum splenectomy.
  94. ncbi Laparoscopic splenectomy for autoimmune hemolytic anemia in patients with chronic lymphocytic leukemia: a case series and review of the literature
    John Hill
    Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Hematol 75:134-8. 2004
    The purpose of this study was to evaluate the safety and efficacy of laparoscopic splenectomy in patients with chronic lymphocytic leukemia (CLL) complicated by autoimmune hemolytic anemia...
  95. ncbi The significance of inadvertent splenectomy during colorectal cancer resection
    Marcia L McGory
    Center for Surgical Outcomes and Quality, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, 72 215 Center for Health Sciences, Los Angeles, CA 90095 6904, USA
    Arch Surg 142:668-74. 2007
    To examine the frequency, predictors, and outcomes following inadvertent splenectomy during colorectal cancer resection.
  96. ncbi Upper abdominal surgical procedures: liver mobilization and diaphragm peritonectomy/resection, splenectomy, and distal pancreatectomy
    Siobhan M Kehoe
    Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Gynecol Oncol 111:S51-5. 2008
    ..A comprehensive approach to surgical cytoreduction, which has been associated with improved survival in patients with advanced ovarian cancer, should incorporate upper abdominal resection...
  97. ncbi Successful rescue of refractory acute antibody-mediated renal allograft rejection with splenectomy--a case report
    Isabel Roberti
    Pediatric Nephrology and Transplantation Transplant Surgery, Saint Barnabas Medical Center, Livingston, NJ 07039, USA
    Pediatr Transplant 16:E49-52. 2012
    ..He failed to respond to standard therapy and needed an urgent splenectomy as rescue therapy...
  98. ncbi Delayed traumatic diaphragmatic hernia after open splenectomy: report of a case
    Kazuto Tsuboi
    Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Surg Today 38:352-4. 2008
    ..man experienced sudden chest pain radiating into his left shoulder about 16 months after undergoing an open splenectomy for malignant splenic lymphoma...
  99. ncbi Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Immunol 181:3535-9. 2008
    ..In this study, we report that splenectomy significantly reduces systemic HMGB1 release and improves survival in mice with polymicrobial sepsis...
  100. ncbi Laparoscopic splenectomy with the da Vinci robot
    Johannes Bodner
    Department of General and Transplant Surgery, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Laparoendosc Adv Surg Tech A 15:1-5. 2005
    ..We report our first series of minimally invasive splenectomies with a robotic surgical system...
  101. ncbi Hospital experience, body image, and cosmesis after laparoscopic or open splenectomy
    Aras Emre Canda
    Department of Surgery, Manisa State Hospital, Manisa, Turkey
    Surg Laparosc Endosc Percutan Tech 19:479-83. 2009
    Laparoscopic splenectomy (LS) is becoming the "gold standard" technique for splenectomy. The aim of this study was to evaluate the hospital experience, body image, and cosmesis after LS or open splenectomy (OS).

Research Grants62

  1. Sex differences in brain inflammation in experimental stroke
    Halina Offner; Fiscal Year: 2013
    ..These hypotheses predict that (a) while splenectomy benefits the injured brain of both sexes by eliminating immunocytes nurtured within the spleen, adoptive ..
  2. Determining Optimum Medical Therapy for ITP
    JAMES BRUCE BUSSEL; Fiscal Year: 2013
    ..more high dose steroids, rituximab (ritux), or thrombopoietic agents (TPO agents);or the surgical option, splenectomy. Prednisone leads to lasting effects in very few patients following a second course;high dose dexamethasone (..
  3. Pharmacology and Bioengineering of New Treatment of ITP
    Joseph P Balthasar; Fiscal Year: 2010
    ..25-30% of chronic ITP patients are refractory to standard therapy (corticosteroid immunosuppression and splenectomy) and are at high risk for fatal hemorrhage...
  4. The role of CD36 in ischemic inflammation and injury
    Sunghee Cho; Fiscal Year: 2013
    ..The necessity and sufficiency of spleen monocytes will be investigated in mice that have undergone a splenectomy and in splenectomized mice that have received exogenous spleen monocytes via adoptive transfer...
  5. Mixed Chimerism in Haploidentical Non-human Primates
    Bernhard Hering; Fiscal Year: 2006
    ..across partial major histocompatibility barriers without the need for T cell depletion, thymic irradiation, and splenectomy. It is also hypothesized that the use of highdose hematopoietic cell transplantation overcomes the need for ..
  6. PRECLINICAL BRIDGE TO HUMAN TRANSPLANT TOLERANCE
    Judith Thomas; Fiscal Year: 2000
    ..posttransplant rabbit antithymocyte globulin (RATG), subtotal fractionated limited lymphoid irradiation and splenectomy (LLlI/splx), followed by infusion of a subpopulation of donor bone marrow cells (DBMC)) have demonstrated ..
  7. T CELL ADHESION MOLECULES IN MURINE LUPUS PNEUMONITIS
    Jeffrey Curtis; Fiscal Year: 2002
    ..b>Splenectomy abrogates disease activity in all organs except the lungs, indicating that pathology in this organ does not ..
  8. B Cell Repertoire and B cell Neoplasms in Old Mice
    MARC WEKSLER; Fiscal Year: 2006
    ..transient or stable antigen-specific BLCE will be isolated from cryopreserved, spleen cells obtained by partial splenectomy of 4-6- and 14-18-month-old mice...
  9. COOPERATIVE STUDY OF POLYCYTHEMIA VERA
    Louis Wasserman; Fiscal Year: 1980
    ..in preventing thrombosis in polycythemia vera, 2) to determine the best available form of treatment (drugs, splenectomy, radiation) specifically designed according to the major clinical manifestations, in patients with ..
  10. MODELS OF THROMBOCYTOPENIA PATHOLOGY & TREATMENT
    Steven McKenzie; Fiscal Year: 2002
    ..Major treatment options include splenectomy and intravenous immunoglobulin (IVIG)...
  11. GENDER-SPECIFIC T CELL HOMING AND AUTOIMMUNITY
    Bruce Richardson; Fiscal Year: 2003
    ..Finally, splenectomy prevents the development of autoimmunity...
  12. MONOCLONAL ITP AUTOANTIBODIES--PARADIGM FOR AUTOIMMUNITY
    Donald Siegel; Fiscal Year: 2002
    ..at modifying the humoral immune response are most frequently utilized, such as steroids and chemotherapy, IVIG, splenectomy and, more experimentally, Staph protein A columns...
  13. CELLULAR IMMUNE RESPONSES TO SYNGENEIC TUMORS
    SEI TOKUDA; Fiscal Year: 1980
    ..We have recently demonstrated that splenectomy performed three weeks prior to tumor challenge reduces the mortality from 60-80% to 20-40%...
  14. Training in Transplantation Immunology
    Kenneth Christopher; Fiscal Year: 2003
    ..After splenectomy, LTbeta-R deficient mice ultimately reject allografts with extremely prolonged kinetics...
  15. B(A)P-METABOLISM & MODIFICATION OF DNA IN SKIN XENOGRAFT
    GEORGE MILO; Fiscal Year: 1992
    ..in establishing human skin xenograft, using neonatal foreskins, on nude mice further immunosuppressed by splenectomy. Our several years of experience in studying the metabolism of BP as well as BPDE- DNA adducts in human cells ..
  16. Nuclear translocation of urokinase/nucleolin complexes
    Douglas Cines; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Apoptosis in myelofibrosis with myeloid metaplasia
    Ruben Mesa; Fiscal Year: 2006
    ..abstract_text> ..
  18. DEFENSIN AND THE PATHOGENESIS OF ATHEROSCLEROSIS
    Douglas Cines; Fiscal Year: 2002
    ..Finally, the interaction between endogenous defensin and endogenous Lp(a) will be examined in a novel transgenic mouse than overexpresses both human defensin and human Lp(a). ..
  19. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2002
    ..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..
  20. STRUCTURE/FUNCTION ANALYSIS OF THE UROKINASE RECEPTOR
    Douglas Cines; Fiscal Year: 2002
    ..abstract_text> ..
  21. Bioengineering Methods to Study Blood Substitutes
    Anthony Cheung; Fiscal Year: 2004
    ..abstract_text> ..
  22. Clinical Research Training Institute
    James George; Fiscal Year: 2005
    ..It is through this near one to one ratio with the trainees that ASH intends to foster and sustain interest in clinical hematologic research and thereby help stimulate the career development of future clinical researchers in hematology. ..
  23. 2006 Clinical Research Training Institute
    James George; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  24. Molecular Biology of Erythrocyte Ankyrin
    Patrick G Gallagher; Fiscal Year: 2010
    ..These studies may provide important information to be used for diagnosis and treatment of patients with this disorder. ..
  25. Measuring Cytogenetic Damage in Human Blood
    Stephen Dertinger; Fiscal Year: 2003
    ..abstract_text> ..
  26. Versatile Mutation Assay Platform
    Stephen Dertinger; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  27. In vivo mutation assay based on pig-a locus
    Stephen Dertinger; Fiscal Year: 2004
    ....
  28. High Throughput Radiation Biodosimetry
    Stephen Dertinger; Fiscal Year: 2007
    ..We propose to develop such a radiation biodosimetry assay based on the extremely high analysis rates that are possible with flow cytometry instrumentation. [unreadable] [unreadable] [unreadable]..
  29. Automation of the vitro Micronucleus Assay
    Stephen Dertinger; Fiscal Year: 2004
    ..abstract_text> ..
  30. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006
    ..This work has important implications for the selective inactivation of gene function in allografts through ex vivo gene transfer. ..
  31. Rapid Screen for Genotoxicants, Chemoprotectors, and Radioprotectors
    Stephen Dertinger; Fiscal Year: 2008
    ..In addition, this assay can be used to investigate agents designed to ameliorate the effects of radiation exposure, e.g. biological response modifiers. [unreadable] [unreadable] [unreadable] [unreadable]..
  32. Measurement & modulation of the mutation rate in humans
    David Araten; Fiscal Year: 2007
    ..These studies will begin to elucidate the relationship between f and cancer risk and provide a highly relevant in vitro parameter with which to evaluate chemoprevention. ..
  33. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2007
    ..g. Alzheimer's, demyelinating diseases, brain tumors). [unreadable] [unreadable]..
  34. Modulators of Nitric Oxide Synthase Activity in Sickle Cell Disease
    Mary E Fabry; Fiscal Year: 2010
    ..These observations may be applicable to patient interventions. ..
  35. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  36. Role of Placenta Growth factor in Sickle ACS
    MALIK PUNAM; Fiscal Year: 2008
    ..VEGFR-antagonists are in clinical trials and leukotriene blockers are FDA approved and in clinical use for asthma and could be candidates for an ACS prevention trial. ..
  37. Serum markers of brain barriers
    Damir Janigro; Fiscal Year: 2010
    ..Finally, we will validate the usefulness of these markers in the early detection of recurrent brain tumors or metastases, to specifically address one of the mandates of this PA. ..
  38. A C.elegans high-throughput assay for the identification of new antifungal agents
    Eleftherios Mylonakis; Fiscal Year: 2010
    ....
  39. Influence of Tumor Immunogenicity to Immunotherapy
    Jeffrey Norton; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  40. SCOR IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
    Joseph Witztum; Fiscal Year: 2006
    ..These insights may lead to novel approaches to the treatment and prevention of atherosclerosis. ..
  41. ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDS
    Joseph Witztum; Fiscal Year: 2004
    ..g. aggressive anti-inflammatory and/or antioxidant interventions). ..
  42. MARROW REGULATION IN CYCLIC HEMATOPOIESIS
    David Dale; Fiscal Year: 2003
    ....
  43. INJURY TO LIVER SINUSOIDAL ENDOTHELIAL CELLS
    Steven Strasberg; Fiscal Year: 2003
    ..A potentially beneficial improvements in preservation solutions are identified they will be tested in whole isolated livers and by transplantation in the rat. ..
  44. REGULATION OF CEREBRAL BLOOD FLOW BY ATP
    Damir Janigro; Fiscal Year: 2003
    ..2) To elucidate the mechanisms of potassium-mediated dilations in vivo. These studies will allow better understanding on neuronal-vascular interactions and will open new perspectives for the treatment of neurological diseases. ..
  45. Complement as an Adjuvant in Polysaccharide Immunity
    SAMUEL TEST; Fiscal Year: 2003
    ..pneumoniae will be prepared and evaluated in different strains of mice. These experiments should provide new insights into the immune response to conjugate vaccines and facilitate future efforts to improve vaccine efficacy. ..
  46. B-LYMPHOCYTE MEDIATED IMMUNE MECHANISMS IN ATHEROGENESIS
    Joseph Witztum; Fiscal Year: 2001
    ..These data should provide novel information on T15 B-cell mediated mechanisms in atherogenesis and for the first time characterize "neo-self" ligands to which anti-OxLDL/T15 B cells respond. ..
  47. ERYTHROCYTAPHERESIS TO LOWER IRON LOADING IN THALASSEMIA
    Alan Cohen; Fiscal Year: 2002
    ....
  48. HETEROGENEITY OF HIPPOCAMPAL GLIA
    Damir Janigro; Fiscal Year: 2002
    ..The outcome of the proposed experiments may be useful for further extrapolations applicable to other physiological aspects of glia(c)neuronal interactions. ..
  49. Role of B-1 Lymphocytes in Athergenesis
    Joseph Witztum; Fiscal Year: 2004
    ..These data should provide novel information on T15 B-cell mediated mechanisms in atherogenesis and for the first time characterize oxidation-specific "neo-self" ligands to which anti-OxLDL/T15 B cells respond...
  50. ALCOHOL EFFECTS ON THYMIC IMMUNE RESPONSE TO HAART
    Maria Jose Miguez; Fiscal Year: 2004
    ..abstract_text> ..
  51. Modulation of type I diabetes with NKT cells
    Luc Van Kaer; Fiscal Year: 2006
    ..These studies will provide a better understanding of the immunological mechanisms that result in autoimmunity, and may lead to the development of novel agents for treatment of type I diabetes and other autoimmune diseases. ..
  52. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
    ..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
  53. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    MAMIE COATS; Fiscal Year: 2005
    ..These studies will help physicians predict which S. pneumoniae infections will progress to become HUS and avoid practices that exacerbate HUS. ..
  54. Modulation of EAE with ligand-activated NKT cells
    Luc Van Kaer; Fiscal Year: 2005
    ..These reagents will permit the selective activation of distinct adaptive immune responses in vivo, which could be exploited for therapeutic intervention in MS and other human autoimmune diseases. ..
  55. MIXED CHIMERISM AND TOLERANCE IN CYNOMOLGUS MONKEYS
    Tatsuo Kawai; Fiscal Year: 2005
    ..These analyses should provide valuable information for extending this approach to clinical allotransplantation. ..
  56. MECHANISMS OF MULTIDRUG RESISTANCE
    Damir Janigro; Fiscal Year: 2005
    ..In particular, we are investigating how changes in blood-brain barrier function may drive glia and neurons into an "epileptic" phenotype. ..
  57. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  58. gClqR/p33 in S. Aureus Endovascular Pathogenesis
    Ellinor Peerschke; Fiscal Year: 2005
    ..Results from these studies will define a novel mechanism for S. aureus interactions at sites of endovascular damage, and may identify novel targets for therapeutic intervention. ..
  59. CHILDRENS CANCER GROUP--COMPETITIVE GRANT RENEWAL
    David Baker; Fiscal Year: 2002
    ..The long term objective of the Oncology Division at PMH is to play a more pro-active role in CCG activities including steering and study committees and strategy group membership. ..