amniocentesis

Summary

Summary: Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.

Top Publications

  1. ncbi Amniocentesis results: investigation of anxiety. The ARIA trial
    J Hewison
    Academic Unit of Psychiatry and Behavioural Sciences, University of Leeds, UK
    Health Technol Assess 10:iii, ix-x, 1-78. 2006
  2. ncbi Procedure-related complications of amniocentesis and chorionic villous sampling: a systematic review
    Faris Mujezinovic
    Department of Perinatology, University Clinical Center Maribor, Maribor, Slovenia
    Obstet Gynecol 110:687-94. 2007
  3. ncbi Microbial invasion and cytokine response in amniotic fluid in a Swedish population of women with preterm prelabor rupture of membranes
    Bo Jacobsson
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Obstet Gynecol Scand 82:423-31. 2003
  4. ncbi Amniocentesis and mother-to-child human immunodeficiency virus transmission in the Agence Nationale de Recherches sur le SIDA et les Hépatites Virales French Perinatal Cohort
    Laurent Mandelbrot
    Assistance Publique Hopitaux de Paris AP HP, Service de Gynecologie Obstetrique, Hopital Louis Mourier, Colombes, and Université Paris 7 Diderot, Paris, France
    Am J Obstet Gynecol 200:160.e1-9. 2009
  5. ncbi Amniotic fluid interleukin-6 and tumor necrosis factor-alpha at mid-trimester genetic amniocentesis: relationship to intra-amniotic microbial invasion and preterm delivery
    Nikolaos Thomakos
    1st Department of Obstetrics and Gynecology, Alexandra Maternity Hospital, Athens University, Athens, Greece
    Eur J Obstet Gynecol Reprod Biol 148:147-51. 2010
  6. ncbi An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery
    B H Yoon
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea
    Am J Obstet Gynecol 185:1162-7. 2001
  7. ncbi Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes
    B H Yoon
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea
    Am J Obstet Gynecol 185:1130-6. 2001
  8. ncbi Fetal loss rate after chorionic villus sampling and amniocentesis: an 11-year national registry study
    A Tabor
    Department of Fetal Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Ultrasound Obstet Gynecol 34:19-24. 2009
  9. pmc Performance characteristics of putative tests for subclinical chorioamnionitis
    R K Edwards
    Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville 32610-0294, USA
    Infect Dis Obstet Gynecol 9:209-14. 2001
  10. ncbi Ultrasound findings before amniocentesis in selecting the method of analysing the sample
    Karl O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Prenat Diagn 27:34-9. 2007

Detail Information

Publications307 found, 100 shown here

  1. ncbi Amniocentesis results: investigation of anxiety. The ARIA trial
    J Hewison
    Academic Unit of Psychiatry and Behavioural Sciences, University of Leeds, UK
    Health Technol Assess 10:iii, ix-x, 1-78. 2006
    The Amniocentesis Results: Investigation of Anxiety (ARIA) trial tested two hypotheses: first, that giving amniocentesis results out on a fixed date alters maternal anxiety during the waiting period, compared with a policy of telling ..
  2. ncbi Procedure-related complications of amniocentesis and chorionic villous sampling: a systematic review
    Faris Mujezinovic
    Department of Perinatology, University Clinical Center Maribor, Maribor, Slovenia
    Obstet Gynecol 110:687-94. 2007
    To compile a systematic review of complications related to genetic amniocentesis and chorionic villus sampling (CVS) to provide benchmark data for counseling and performance assessment of individual operators.
  3. ncbi Microbial invasion and cytokine response in amniotic fluid in a Swedish population of women with preterm prelabor rupture of membranes
    Bo Jacobsson
    Perinatal Center, Department of Obstetrics and Gynecology, Institute for the Health of Women and Children, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Obstet Gynecol Scand 82:423-31. 2003
    ....
  4. ncbi Amniocentesis and mother-to-child human immunodeficiency virus transmission in the Agence Nationale de Recherches sur le SIDA et les Hépatites Virales French Perinatal Cohort
    Laurent Mandelbrot
    Assistance Publique Hopitaux de Paris AP HP, Service de Gynecologie Obstetrique, Hopital Louis Mourier, Colombes, and Université Paris 7 Diderot, Paris, France
    Am J Obstet Gynecol 200:160.e1-9. 2009
    The objective of the study was to investigate whether performing an amniocentesis increased mother-to-child transmission of human immunodeficiency virus (HIV)-1 (MTCT).
  5. ncbi Amniotic fluid interleukin-6 and tumor necrosis factor-alpha at mid-trimester genetic amniocentesis: relationship to intra-amniotic microbial invasion and preterm delivery
    Nikolaos Thomakos
    1st Department of Obstetrics and Gynecology, Alexandra Maternity Hospital, Athens University, Athens, Greece
    Eur J Obstet Gynecol Reprod Biol 148:147-51. 2010
    ..To determine the value of amniotic fluid interleukin-6 (AF IL-6) and tumor necrosis factor-alpha (AF TNF-alpha) in the diagnosis of microbial invasion of the amniotic cavity and in the prediction of preterm delivery (PTD)...
  6. ncbi An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery
    B H Yoon
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea
    Am J Obstet Gynecol 185:1162-7. 2001
    ..angiogenin can identify patients at risk for spontaneous preterm delivery in patients undergoing mid-trimester amniocentesis. STUDY DESIGN: A case-control study was conducted to compare mid-trimester concentrations of amniotic fluid ..
  7. ncbi Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes
    B H Yoon
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea
    Am J Obstet Gynecol 185:1130-6. 2001
    ..STUDY DESIGN: Amniocentesis was performed in 206 patients with preterm labor and intact membranes...
  8. ncbi Fetal loss rate after chorionic villus sampling and amniocentesis: an 11-year national registry study
    A Tabor
    Department of Fetal Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Ultrasound Obstet Gynecol 34:19-24. 2009
    To assess the fetal loss rate following amniocentesis and chorionic villus sampling (CVS).
  9. pmc Performance characteristics of putative tests for subclinical chorioamnionitis
    R K Edwards
    Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville 32610-0294, USA
    Infect Dis Obstet Gynecol 9:209-14. 2001
    ..women in preterm labor at 22-35 weeks gestation with suspected subclinical chorioamnionitis underwent amniocentesis. Amniotic fluid analysis included Gram stain, culture, and determination of glucose, MMP-9, IL-6, and IL-12 ..
  10. ncbi Ultrasound findings before amniocentesis in selecting the method of analysing the sample
    Karl O Kagan
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Prenat Diagn 27:34-9. 2007
    To determine if the primary method of cytogenetic analysis in pregnant women undergoing amniocentesis should be quantitative fluorescent polymerase chain reaction (qf-PCR), with karyotyping being performed only on those with abnormal ..
  11. ncbi Chronic viral infections and invasive procedures: risk of vertical transmission and current recommendations
    Marta Lopez
    Maternal Fetal Medicine Department, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, University of Barcelona, Barcelona, Spain
    Fetal Diagn Ther 28:1-8. 2010
    ..The risk of hepatitis B transmission during amniocentesis seems to be low, but it may be increased in women with a positive HBeAg...
  12. ncbi Fetal loss rate and associated risk factors after amniocentesis, chorionic villus sampling and fetal blood sampling
    C Enzensberger
    OB and GYN, Division of Prenatal Medicine, University Gießen and Marburg
    Ultraschall Med 33:E75-9. 2012
    To assess the total and procedure-related fetal loss rate and associated risk factors following amniocentesis (AC), chorionic villus sampling (CVS) and fetal blood sampling (FBS).
  13. pmc Screening for Down's syndrome: effects, safety, and cost effectiveness of first and second trimester strategies
    R E Gilbert
    Systematic Reviews Training Unit, Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH
    BMJ 323:423-5. 2001
    ..To compare the effects, safety, and cost effectiveness of antenatal screening strategies for Down's syndrome...
  14. ncbi Mid-trimester amniocentesis fetal loss rate
    R Douglas Wilson
    J Obstet Gynaecol Can 29:586-95. 2007
    To determine the postprocedure loss rate for mid-trimester genetic amniocentesis.
  15. ncbi Prenatal diagnosis in human immunodeficiency virus-infected women: a new screening program for chromosomal anomalies
    Oriol Coll
    Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Barcelona, Spain
    Am J Obstet Gynecol 194:192-8. 2006
    ..This study was undertaken to describe a new prenatal diagnosis program among human immunodeficiency virus (HIV)-infected women, and the perinatal outcome of this program's application over a more than 2-year period...
  16. ncbi Early invasive diagnostic techniques in pregnant women who are infected with the HIV: a multicenter case series
    Edgardo Somigliana
    Department of Obstetrics Gynecology and Neonatology, L Mangiagalli Hospital, Milan, Italy
    Am J Obstet Gynecol 193:437-42. 2005
    ....
  17. ncbi Individual risk of fetal loss following routine second trimester amniocentesis: a controlled study of 20,460 cases
    P Kozlowski
    Pränatal Medizin und Genetik Duesseldorf
    Ultraschall Med 29:165-72. 2008
    The aim of this study was to evaluate the impact of maternal risk factors on excess fetal loss related to amniocentesis.
  18. ncbi Cervical length and gestational age at admission as predictors of intra-amniotic inflammation in preterm labor with intact membranes
    M Palacio
    Department of Maternal Fetal Medicine, Institute Clinic of Gynecology, Obstetrics and Neonatology, Barcelona, Spain
    Ultrasound Obstet Gynecol 34:441-7. 2009
    ..To evaluate cervical length and gestational age as predictors of intra-amniotic inflammation in patients admitted because of preterm labor and intact membranes...
  19. ncbi Antibiotic prophylaxis before second-trimester genetic amniocentesis (APGA): a single-centre open randomised controlled trial
    Claudio Giorlandino
    Department of Prenatal Diagnosis, Artemisia Fetal Maternal Medical Centre, Rome, Italy
    Prenat Diagn 29:606-12. 2009
    To compare procedure-related pregnancy loss after second-trimester genetic amniocentesis in women given an antibiotic prophylaxis and controls.
  20. ncbi Diagnostic mid trimester amniocentesis: how safe?
    John W Seeds
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Obstet Gynecol 191:607-15. 2004
    Genetic mid-trimester amniocentesis is a common invasive procedure. The origin of the commonly quoted 0...
  21. ncbi IGFBP-1 levels in cervicovaginal secretions before and after amniocentesis
    R Devlieger
    Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, Leuven, Belgium
    Gynecol Obstet Invest 67:9-13. 2009
    To evaluate the levels of insulin-like growth factor-binding protein-1 (IGFBP-1) in cervicovaginal secretions before and after midtrimester amniocentesis and relate to clinical outcome.
  22. ncbi Pregnancy loss rate after mid-trimester amniocentesis in twin pregnancies
    Alison G Cahill
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA
    Am J Obstet Gynecol 200:257.e1-6. 2009
    The purpose of this study was to estimate the attributable pregnancy loss rate of mid-trimester amniocentesis in twin pregnancies.
  23. ncbi Comparison of multiplex ligation-dependent probe amplification and karyotyping in prenatal diagnosis
    Elisabeth M Boormans
    Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Obstet Gynecol 115:297-303. 2010
    ....
  24. ncbi Effect of pre-amniocentesis counseling on maternal pain and anxiety
    Osman Balci
    Department of Obstetrics and Gynecology, Meram Medicine Faculty, Selcuk University, Konya, Turkey
    J Obstet Gynaecol Res 37:1828-32. 2011
    ..of anticipated and perceived pain and anxiety in expectant mothers at the times of pre-counseling, post-counseling, and post-amniocentesis and to investigate the effect of pre-amniocentesis counseling on the level of pain and anxiety.
  25. ncbi Maternal mortality following diagnostic 2nd-trimester amniocentesis
    Uriel Elchalal
    Department of Obstetrics and Gynecology, Hadassah University Hospital, Eim Kerem, Hebrew University, Jerusalem, Israel
    Fetal Diagn Ther 19:195-8. 2004
    We present 2 cases of maternal mortality after transabdominal amniocentesis performed during the 2nd trimester of pregnancy. In both these cases, blood cultures revealed Escherichia coli...
  26. pmc Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: temporal trends and timing of amniocentesis in pregnancy
    Morten Søndergaard Jensen
    Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Environ Health Perspect 120:897-903. 2012
    ..Measures of prenatal environmental exposures are important, and amniotic fluid levels may directly reflect fetal exposures during hypothesized windows of vulnerability...
  27. ncbi Gender differences in amniotic fluid cytokine levels
    S H Poggi
    Department of Obstetrics and Gynecology, Georgetown University Hospital, 3800 Reservoir Road, Washington, DC 20007, USA
    J Matern Fetal Neonatal Med 15:367-71. 2004
    ..We investigated whether fetal gender affects amniotic fluid levels of the inflammatory cytokines interleukin (IL)-6 and IL-10 and the pro-angiogenesis cytokine angiogenin...
  28. ncbi Fetal loss associated with second trimester amniocentesis
    Somsri Pitukkijronnakorn
    Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
    Arch Gynecol Obstet 284:793-7. 2011
    To evaluate the fetal loss rate associated with second trimester amniocentesis.
  29. ncbi Dimeric inhibins in amniotic fluid, maternal serum, and fetal serum in human pregnancy
    E M Wallace
    Department of Obstetrics and Gynecology, University of Edinburgh, United Kingdom
    J Clin Endocrinol Metab 82:218-22. 1997
    ..Further, the presence of inhibin B in male fetuses is consistent with a testicular origin, suggesting that inhibin B may be important in the development of the fetal hypothalamo-pituitary-testicular axis...
  30. ncbi A short cervix in women with preterm labor and intact membranes: a risk factor for microbial invasion of the amniotic cavity
    Ricardo Gomez
    Center for Perinatal Diagnosis and Research CEDIP, Sotero del Rio Hospital, P Universidad Catolica de Chile, Puente Alto, Chile
    Am J Obstet Gynecol 192:678-89. 2005
    ..The purpose of this study was to determine whether there was a relationship between sonographic cervical length and the presence of culture-proven microbial invasion of the amniotic cavity in women with preterm labor and intact membranes...
  31. ncbi Information and decision support needs of parents considering amniocentesis: interviews with pregnant women and health professionals
    Marie Anne Durand
    Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff, UK
    Health Expect 13:125-38. 2010
    Our aim was to clarify and categorize information and decision support needs of pregnant women deciding about amniocentesis.
  32. ncbi Women of advanced maternal age undergoing amniocentesis: a period of uncertainty
    Jui Chiung Sun
    School of Nursing, National Yang Ming University, Taipei, Taiwan
    J Clin Nurs 17:2829-37. 2008
    To generate a descriptive model for understanding patterns and interpretations concerning women's experiences of amniocentesis in Taiwan.
  33. ncbi Outcome of twin pregnancies after amniocentesis
    Anita Sik Yau Kan
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hospital, Hong Kong, China
    J Obstet Gynaecol Res 38:376-82. 2012
    The aim of this study was to assess the miscarriage and fetal loss rates of twin pregnancies after amniocentesis.
  34. ncbi Cortisol and anxiety response to a relaxing intervention on pregnant women awaiting amniocentesis
    T Ventura
    Hospital Dona Estefânia, Centro Hospitalar de Lisboa Central, Rua Jacinta Marto, 1169 045 Lisbon, Portugal
    Psychoneuroendocrinology 37:148-56. 2012
    ..However, medication for stress may carry risks to the expectant mother, therefore the efficacy of non-pharmacological interventions should be investigated...
  35. ncbi Risks of third-trimester amniocentesis
    Ivica Zalud
    Department of Obstetrics Gynecology and Women s Health, Kapiolani Medical Center for Women and Children, John A Burns School of Medicine, University of Hawaii, 13419 Punahou Street, Honolulu, HI 96734, USA
    J Reprod Med 53:45-8. 2008
    To establish the risk of immediate complications from third-trimester amniocentesis.
  36. ncbi Psychological response to prenatal genetic counseling and amniocentesis
    K P Tercyak
    Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
    Patient Educ Couns 43:73-84. 2001
    ..women at increased risk for fetal genetic anomalies who were referred for prenatal genetic counseling and amniocentesis; to determine which of these factors would predict amniocentesis use; and to identify patient outcomes ..
  37. ncbi Amniotic fluid testosterone: relationship with cortisol and gestational age
    P Sarkar
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    Clin Endocrinol (Oxf) 67:743-7. 2007
    ..Although best investigated in foetal plasma, this is now difficult because of the decline in frequency of foetal blood sampling; in this study, we used amniotic fluid as a biomarker to investigate foetal exposure...
  38. ncbi Amniotic fluid matrix metalloproteinase-9 and interleukin-6 in predicting intra-amniotic infection
    Hassan Harirah
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 99:80-4. 2002
    ..To assess the potential role of amniotic fluid (AF) matrix metalloproteinase-9 and interleukin-6 in predicting intra-amniotic infection...
  39. ncbi Amniotic fluid interleukin-18 at mid-trimester genetic amniocentesis: relationship to intraamniotic microbial invasion and preterm delivery
    G Daskalakis
    First Department of Obstetrics and Gynaecology, Alexandra Maternity Hospital, and Department of Biological Chemistry, Athens University, Athens, Greece
    BJOG 116:1743-8. 2009
    ..To determine the value of amniotic fluid interleukin-18 (AF IL-18) in the diagnosis of microbial invasion of the amniotic cavity and prediction of preterm delivery (PTD)...
  40. pmc Multiplex ligation-dependent probe amplification versus karyotyping in prenatal diagnosis: the M.A.K.E. study
    Elisabeth M A Boormans
    Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, The Netherlands
    BMC Pregnancy Childbirth 8:18. 2008
    ..Multiplex ligation-dependent probe amplification (MLPA) is a new molecular genetic technique in prenatal diagnosis. Previous preclinical evidence suggests equivalence of MLPA and traditional karyotyping (TKT) regarding test performance...
  41. ncbi Rapid aneuploidy screening (FISH or QF-PCR): the changing scene in prenatal diagnosis?
    W C Leung
    Prenatal Diagnostic and Counseling Department, Tsan Yuk Hospital, University of Hong Kong, Hong Kong SAR, China
    Expert Rev Mol Diagn 4:333-7. 2004
    ..The ten most recent studies from the literature within this research theme are reviewed and the pros and cons of this new approach in prenatal diagnosis are discussed, including the suggestion of future studies...
  42. ncbi Economic evaluation of prenatal diagnosis: a methodological review
    P Shackley
    Health Economics Research Unit, Department of Public Health, Foresterhill, Aberdeen
    Prenat Diagn 16:389-95. 1996
    ..The various methods of economic evaluation are discussed in the context of amniocentesis and chorionic villus sampling...
  43. ncbi Infant morbidity following amniocentesis and chorionic villus sampling for prenatal karyotyping
    Maria Cederholm
    Department of Women s and Children s Health, Section of Obstetrics and Gynaecology, Uppsala University, SE 751 85 Uppsala, Sweden
    BJOG 112:394-402. 2005
    To investigate whether amniocentesis and chorionic villus sampling increase the risk of postural deformities, limb reduction defects, respiratory problems in the newborn, fetal and infant mortality, prematurity, low birthweight and fetal ..
  44. pmc A sonographic short cervix as the only clinical manifestation of intra-amniotic infection
    Sonia Hassan
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Wayne State University, Hutzel Women s Hospital, 3990 John R, 7 Brush North, MFM Mail Drawer 163, Detroit, MI 48201, USA
    J Perinat Med 34:13-9. 2006
    ..This study was conducted to determine the rate of MIAC and intra-amniotic inflammation in patients with a cervical length < 25 mm in the mid-trimester...
  45. ncbi Chorioamnionitis and intrauterine fetal death after second-trimester amniocentesis
    Marguerite Vigliani
    Women and Infants Hospital, Department of Obstetrics and Gynecology, Warren Alpert School of Medicine at Brown University, Providence, RI, USA marguerite_vigliani brown edu
    Fetal Diagn Ther 26:216-8. 2009
    We report an intrauterine fetal death that occurred less than 24 h after transabdominal amniocentesis. Chorioamnionitis was confirmed by amniotic fluid culture which showed multiple enteric organisms and postmortem examination of the ..
  46. ncbi Cell-free fetal DNA in maternal circulation after amniocentesis
    Osamu Samura
    Department of Obstetrics and Gynecology, Hiroshima University Faculty of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Clin Chem 49:1193-5. 2003
  47. ncbi Congenital toxoplasmosis: necessity of clinical and ultrasound follow-up despite negative amniocentesis
    Isabelle Villena
    Prenat Diagn 23:1098-9. 2003
  48. ncbi Chorionic villus sampling and amniocentesis
    Bruno Brambati
    Center of Prenatal Diagnosis, Milan, Italy
    Curr Opin Obstet Gynecol 17:197-201. 2005
    ..The advantages and disadvantages of common invasive methods for prenatal diagnosis are presented in light of new investigations...
  49. ncbi Rapid detection of chromosomal aneuploidies in uncultured amniocytes by multiplex ligation-dependent probe amplification (MLPA)
    R Hochstenbach
    Department of Biomedical Genetics, University Medical Center Utrecht, The Netherlands
    Prenat Diagn 25:1032-9. 2005
    ..To test whether multiplex ligation-dependent probe amplification (MLPA) can be used for the detection of aneuploidy of chromosomes 13, 18, 21, X, and Y in uncultured amniocytes...
  50. ncbi Detection of chromosome aberrations in the second trimester using genetic amniocentesis: experience during 1995-2004
    Jenn Jhy Tseng
    Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Hung Kuang University, Taichung, and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Taiwan J Obstet Gynecol 45:39-41. 2006
    To retrospectively investigate the 10-year experience of prenatal diagnosis of fetal chromosome aberrations by second-trimester amniocentesis.
  51. ncbi Chorionic villus sampling compared with amniocentesis and the difference in the rate of pregnancy loss
    Aaron B Caughey
    Division of Perinatal Medicine and Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA
    Obstet Gynecol 108:612-6. 2006
    To compare loss rates following amniocentesis and chorionic villus sampling (CVS) over time.
  52. ncbi Techniques for chorionic villus sampling and amniocentesis: a survey of practice in specialist UK centres
    A J Carlin
    Department of Obstetrics and Gynaecology, Liverpool Women s Hospital, Liverpool, UK
    Prenat Diagn 28:914-9. 2008
    Guidelines exist for amniocentesis and chorionic villous sampling (CVS) practice, but there is no consensus regarding individual techniques. Our survey sought to review current practice within specialist centres in the United Kingdom.
  53. ncbi Rapid prenatal diagnostic testing for Down syndrome only or longer wait for full karyotype: the views of pregnant women
    Mandy Ryan
    Health Economics Research Unit, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Prenat Diagn 25:1206-11. 2005
    ..This study investigates the value pregnant women place on these alternative prenatal diagnostic tests...
  54. ncbi [Genetic amniocentesis in high-risk populations. Experience in 3081 cases]
    Mabel Cerrillo Hinojosa
    Clinica de Reproducción y Genetica Hospital Angeles del Pedregal
    Ginecol Obstet Mex 77:173-82. 2009
    ..However, Mexico has been performed only in private hospitals and the National Medical Center November 20 ISSSTE and the National Institute of Perinatology...
  55. pmc Amniocentesis in twin pregnancies: a systematic review of the literature
    Joy Vink
    Department of Ob Gyn, Division of Maternal Fetal Medicine, Columbia University Medical Center, New York, NY 347 880 2492 USA
    Prenat Diagn 32:409-16. 2012
    Using published data, we sought to determine the amniocentesis-related loss rate in twin gestations.
  56. ncbi Does indomethacin prevent preterm birth in women with cervical dilatation in the second trimester?
    Vincenzo Berghella
    Departments of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Perinatol 26:13-9. 2009
    ..23, 1.14) suggested a possible but not significant benefit for indomethacin use. Indomethacin therapy in women with dilated cervix at 14 (0)/ (7) to 25 (6)/ (7) weeks, regardless of cerclage or not, had no effect on pregnancy outcomes...
  57. ncbi Elevated amniotic fluid C-reactive protein at the time of genetic amniocentesis is a marker for preterm delivery
    Fabio Ghezzi
    Department of Obstetrics and Gynecology, University of Insubria, Circolo Hospital, Varese, Italy
    Am J Obstet Gynecol 186:268-73. 2002
    ..The objective of this study was to investigate whether the amniotic fluid C-reactive protein level at the time of genetic amniocentesis is a marker for spontaneous preterm delivery before 34 and 37 weeks of gestation.
  58. ncbi A case of successful management of maternal septic shock with multiple organ failure following amniocentesis at midgestation
    Junzo Hamanishi
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Japan
    J Obstet Gynaecol Res 28:258-61. 2002
    Maternal sepsis is an unusual but catastrophic complication of amniocentesis. We report a case of successful treatment of maternal septic shock and multiple organ failure following amniocentesis at midgestation, possibly due to needle ..
  59. ncbi Revisiting the fetal loss rate after second-trimester genetic amniocentesis: a single center's 16-year experience
    Anthony O Odibo
    Division of Maternal Fetal Medicine, Ultrasound and Genetics, Department of Obstetrics and Gynecology, Washington University in St Louis, Missouri 63110, USA
    Obstet Gynecol 111:589-95. 2008
    To estimate an institution's specific fetal loss rate after a second-trimester genetic amniocentesis.
  60. ncbi How unexpected are unexpected findings in prenatal cytogenetic diagnosis? A literature review
    Myra C B van Zwieten
    Academic Medical Center University of Amsterdam, Division Clinical Methods and Public Health, Department of General Practice Family Medicine, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 120:15-21. 2005
    ..Before targeted testing can be applied it is necessary to establish exact criteria in order to discern unexpected findings from standard testing results...
  61. ncbi Racial-ethnic differences in genetic amniocentesis uptake
    Jennifer B Saucier
    Genzyme Genetics, Austin, Texas 78628, USA
    J Genet Couns 14:189-95. 2005
    The objective of this study was to determine the role of health beliefs in genetic amniocentesis acceptance in a diverse racial-ethnic population...
  62. ncbi Assessment of maternal anxiety levels before and after amniocentesis
    C C M Ng
    Department of Maternal Foetal Medicine, KK Women s and Children s Hospital, 100 Bukit Timah Road, Singapore
    Singapore Med J 45:370-4. 2004
    To assess anxiety levels in mothers before and after undergoing amniocentesis. The secondary aim was to see how counselling by nurse-counsellors affected maternal anxiety levels.
  63. pmc Ethnicity, bioethics, and prenatal diagnosis: the amniocentesis decisions of Mexican-origin women and their partners
    C H Browner
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024 1759, USA
    Am J Public Health 89:1658-66. 1999
    ..include ethnic minority women, who, with the exception of women from certain Asian groups, refuse amniocentesis at significantly higher rates than others...
  64. ncbi Maternal anxiety at amniocentesis and plasma cortisol
    P Sarkar
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, UK
    Prenat Diagn 26:505-9. 2006
    To assess whether anticipation of amniocentesis is linked with maternal anxiety, and whether this anxiety is associated with increased maternal plasma cortisol.
  65. ncbi Clostridium welchii infection following amniocentesis: a case report and review of the literature
    H Hamoda
    Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford, UK
    Prenat Diagn 22:783-5. 2002
    We report a case of severe Clostridium welchii infection following amniocentesis with septicaemia, haemolysis, DIC, pulmonary oedema and renal failure...
  66. ncbi Genetic amniocentesis: a risk factor for preterm delivery?
    Emanuela Medda
    Department of Epidemiology and Biostatistics, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Eur J Obstet Gynecol Reprod Biol 110:153-8. 2003
    To determine whether genetic amniocentesis performed in the second trimester of pregnancy is associated with the risk of preterm delivery.
  67. ncbi Prenatal diagnosis by amniocentesis and chorionic villus biopsy of mtDNA mutation 8993T > G
    R Pettman
    Maritime Medical Genetics Service, IWK Health Centre, Halifax, Nova Scotia, Canada
    J Inherit Metab Dis 30:404. 2007
    ..She underwent prenatal testing by both CVS and amniocentesis of the 8993T > G heteroplasmy levels. This is the first reported case in which both procedures were used...
  68. ncbi A review of decision support technologies for amniocentesis
    M A Durand
    Department of Primary Care and Public Health, School of Medicine, Cardiff University, Neuadd Meirionnydd, Health Park CF14 4YS, UK
    Hum Reprod Update 14:659-68. 2008
    ..The purpose of this review was to describe and evaluate existing DSTs for amniocentesis testing.
  69. ncbi Fetal loss after amniocentesis in a series of 5,780 procedures
    P Gaudry
    Department of Obstetrics and Gynecology, Hopital d Instruction des armees BEGIN, Saint Mande, France
    Fetal Diagn Ther 23:217-21. 2008
    Counseling on prenatal diagnosis requires accurate knowledge of the associated risks, including fetal loss. The objective of our study was to assess this risk of amniocentesis in a single center with several operators.
  70. ncbi Amniocentesis and women with hepatitis B, hepatitis C, or human immunodeficiency virus
    Gregory Davies
    J Obstet Gynaecol Can 25:145-48, 149-52. 2003
    To review the risk of in utero infection through amniocentesis in women with hepatitis B, hepatitis C, or human immunodeficiency virus (HIV).
  71. ncbi Value of amniocentesis versus fetal tissue for cytogenetic analysis in cases of fetal demise
    Ann E Bryant Borders
    Division of Maternal Fetal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Fetal Diagn Ther 26:81-4. 2009
    ..We reviewed our ongoing use of amniocentesis prior to uterine evacuation to determine if this provided a better source of cells for cytogenetic analysis.
  72. ncbi Fetal toxoplasmosis and negative amniocentesis: necessity of an ultrasound follow-up
    Françoise Gay-Andrieu
    Laboratoire de Parasitologie et Pathologie Exotique, Hopital de la Croix Rousse, 93 Grande Rue de la Croix Rousse, 69317 Lyon Cedex 04, France
    Prenat Diagn 23:558-60. 2003
    ..These observations confirm the necessity to continue a monthly ultrasound follow-up, even if amniocentesis is negative, in case of fetal toxoplasma infection in pregnancy.
  73. ncbi HIV detection in amniotic fluid samples. Amniocentesis can be performed in HIV pregnant women?
    Vicente Maiques
    Obstetric Service, Hospital Maternal La FE, 5 degrees Planta, Avda Campanar 21, 46009, Valencia, Spain
    Eur J Obstet Gynecol Reprod Biol 108:137-41. 2003
    To assess amniotic fluid (AF) HIV contamination as a marker of intrauterine HIV infection and to evaluate amniocentesis as a risk factor for vertical HIV transmission when the mother was under antiretroviral treatment.
  74. ncbi Chorionic villus sampling and amniocentesis in 2008
    Mark I Evans
    Fetal Medicine Foundation of America, New York, New York, USA
    Curr Opin Obstet Gynecol 20:164-8. 2008
    ..have been wide discrepancies between quoted risks of diagnostic procedures (chorionic villus sampling and amniocentesis) yet little properly controlled and randomized data to back often dogmatic assertions...
  75. ncbi The clinical significance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patients with preterm labor
    Bo Hyun Yoon
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    Am J Obstet Gynecol 189:919-24. 2003
    ..This study was undertaken to determine the clinical significance of a detection of Ureaplasma urealyticum by using the polymerase chain reaction (PCR) in the amniotic fluid of patients with preterm labor and intact membranes...
  76. ncbi Rapid prenatal diagnosis of aneuploidies and zygosity in multiple pregnancies by amniocentesis with single insertion of the needle and quantitative fluorescent PCR
    Vincenzo Cirigliano
    Department of Molecular Genetics, General Lab, Barcelona, Spain
    Prenat Diagn 23:629-33. 2003
    ....
  77. ncbi Endoscopic laser surgery versus serial amnioreduction for severe twin-to-twin transfusion syndrome
    Marie Victoire Senat
    Department of Obstetrics and Gynecology, Université Paris Ouest Versailles St Quentin, Centre Hospitalier Intercommunale Poissy St Germain, Poissy, France
    N Engl J Med 351:136-44. 2004
    ..We conducted a randomized trial to compare the efficacy and safety of these two treatments...
  78. ncbi Human cytomegalovirus (HCMV) DNAemia in the mother at amniocentesis as a risk factor for iatrogenic HCMV infection of the fetus
    Maria Grazia Revello
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Infect Dis 197:593-6. 2008
    ..73 mothers of uninfected fetuses and 22 (37%) of 59 mothers of infected fetuses were HCMV DNAemia-positive at amniocentesis. Of the 8 mothers of the 8 fetuses with false-negative amniocentesis results, 4 were DNAemia-positive and 4 ..
  79. ncbi Pregnancy loss rate following routine genetic amniocentesis at Wellington Hospital
    Michel Sangalli
    Department of Obstetrics and Gynaecology, Wellington School of Medicine and Health Sciences CCDHB, Wellington Women s Hospital, Wellington, New Zealand
    N Z Med J 117:U818. 2004
    To determine the institutional pregnancy loss rate following second-trimester genetic amniocentesis.
  80. ncbi Mid-trimester amniocentesis and antibiotic prophylaxis
    Dandolo Gramellini
    Department of Gynecology, Obstetrics and Neonatology, University of Parma, Parma, Italy
    Prenat Diagn 27:956-9. 2007
    Assuming that the rate of fetal loss after amniocentesis may be reduced in patients receiving antibiotic prophylaxis, we conducted a retrospective study on untreated versus treated patients receiving prophylactic antibiotics (amoxicillin/..
  81. ncbi Incorporating first-trimester Down syndrome studies into prenatal screening: executive summary of the National Institute of Child Health and Human Development workshop
    Uma M Reddy
    Pregnancy and Perinatology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7510, USA
    Obstet Gynecol 107:167-73. 2006
    ..These requirements include training and quality control standards for first-trimester nuchal translucency measurement and laboratory assays, access to chorionic villus sampling, and appropriate counseling regarding screening options...
  82. ncbi C-reactive protein concentration in vaginal fluid as a marker for intra-amniotic inflammation/infection in preterm premature rupture of membranes
    Soon Sup Shim
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    J Matern Fetal Neonatal Med 18:417-22. 2005
    ....
  83. ncbi Age-specific risk of fetal loss post second trimester amniocentesis: analysis of 5043 cases
    Vincenzo Mazza
    Prenatal Medicine Unit, Department of Obstetrics and Gynecology, Modena and Reggio Emilia University, Italy
    Prenat Diagn 27:180-3. 2007
    To assess the risk of fetal loss attributable to second trimester amniocentesis in singleton pregnancies through a cross-sectional study.
  84. ncbi Routine assessment of amniotic fluid alpha-Fetoprotein in early second-trimester amniocentesis is no longer justified
    Kjerstin Ferm Widlund
    Department of Obstetrics and Gynecology, Vrinnevi Hospital, Centre of Pediatrics and Obstetrics in Ostergötland, Norrkoping, Sweden
    Acta Obstet Gynecol Scand 86:167-71. 2007
    ..years there has been a routine to measure amniotic fluid alpha-Fetoprotein in conjunction with early genetic amniocentesis. The efficacy of such a screening test in a low-risk population has been questioned but never evaluated in a ..
  85. ncbi Does local anesthesia decrease pain perception in women undergoing amniocentesis?
    Michael C Gordon
    Department of Obstetrics and Gynecology, Wilford Hall United Stated Air Force Medical Center, Lackland Air Force Base, TX, USA
    Am J Obstet Gynecol 196:55.e1-4. 2007
    The null hypothesis is that local anesthesia does not decrease pain perception during amniocentesis.
  86. ncbi An elevated maternal plasma, but not amniotic fluid, soluble fms-like tyrosine kinase-1 (sFlt-1) at the time of mid-trimester genetic amniocentesis is a risk factor for preeclampsia
    Chan Wook Park
    Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea
    Am J Obstet Gynecol 193:984-9. 2005
    ..The purpose of this study was to determine if an elevated concentration of soluble fms-like tyrosine kinase-1(sFlt-1) in maternal plasma and amniotic fluid is a risk factor for the subsequent development of preeclampsia...
  87. ncbi Prenatal detection of Down's syndrome by rapid aneuploidy testing for chromosomes 13, 18, and 21 by FISH or PCR without a full karyotype: a cytogenetic risk assessment
    Allan Caine
    Regional Cytogenetics Unit, St James University Hospital, Leeds, UK
    Lancet 366:123-8. 2005
    ..The UKNSC also recommended that FISH or PCR tests should only include trisomies 13, 18, and 21. We undertook a retrospective cytogenetic audit to assess the probable clinical effect of these proposed policy changes...
  88. ncbi Proteomic biomarkers that predict the clinical success of rescue cerclage
    Carl P Weiner
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201 1559, USA
    Am J Obstet Gynecol 192:710-8. 2005
    ..We tested amniotic fluid from women who were preparing to undergo rescue cerclage for proteomic biomarkers and correlated their presence with clinical outcome...
  89. ncbi FastFISH: technique for ultrarapid fluorescence in situ hybridization on uncultured amniocytes yielding results within 2 h of amniocentesis
    M Choolani
    Diagnostic Biomarker Discovery Laboratory, Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, 119074 Singapore
    Mol Hum Reprod 13:355-9. 2007
    ..fluorescence in situ hybridization (FISH) method (FastFISH) that releases accurate results on the same day as amniocentesis. FastFISH was optimized to be completed within 2 h of sample collection using CEP and LSI probes for ..
  90. ncbi Prenatal diagnostic testing and Down Syndrome in Victoria 1992--2002
    Evelyne E Muggli
    Public Health Genetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Victoria
    Aust N Z J Public Health 28:465-70. 2004
    ..To describe patterns of uptake of prenatal diagnostic testing and prenatal detection rates for Down syndrome in Victoria with regard to maternal age and prenatal screening practices...
  91. ncbi Risk factors for procedure-related fetal losses after mid-trimester genetic amniocentesis
    Choy Wah Kong
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong Shatin, Hong Kong SAR, China
    Prenat Diagn 26:925-30. 2006
    ..of this study was to determine the institutional pregnancy loss rate following second-trimester genetic amniocentesis and to ascertain whether factors exist which would identify pregnancies at increased risk of having a ..
  92. ncbi Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, Connecticut 06520 8063, USA
    BJOG 112:173-81. 2005
    ..We applied proteomic technology (SELDI: surface-enhanced laser desorption ionisation) to identify the proteomic profile of intra-amniotic inflammation...
  93. ncbi Doppler ultrasonography versus amniocentesis to predict fetal anemia
    Dick Oepkes
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 355:156-64. 2006
    Pregnancies complicated by Rh alloimmunization have been evaluated with the use of serial invasive amniocentesis to determine bilirubin levels by measuring in the amniotic fluid the change in optical density at a wavelength of 450 nm (..
  94. ncbi Proteomics technology for the accurate diagnosis of inflammation in twin pregnancies
    Irina A Buhimschi
    Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    BJOG 112:250-5. 2005
  95. ncbi Pregnancy loss rates after midtrimester amniocentesis
    Keith A Eddleman
    Mount Sinai School of Medicine, New York, New York, USA
    Obstet Gynecol 108:1067-72. 2006
    The purpose of this study was to quantify the contemporary procedure-related loss rate after midtrimester amniocentesis using a database generated from patients who were recruited to the First And Second Trimester Evaluation of Risk for ..
  96. ncbi Complications of third-trimester amniocentesis using continuous ultrasound guidance
    Michael C Gordon
    Wilford Hall Medical Center, Lackland Air Force Base, Texas, USA
    Obstet Gynecol 99:255-9. 2002
    The objective of the study was to estimate the risks of third-trimester amniocentesis with continuous ultrasound guidance.
  97. ncbi Decisions about amniocentesis by advanced maternal age patients following maternal serum screening may not always correlate clinically with screening results: need for improvement in informed consent process
    Tina Marini
    Baystate Medical Center, Laboratory Genetics, Western Campus Tuft Medical School, Springfield, Massachusetts, USA
    Am J Med Genet 109:171-5. 2002
    ..who underwent serum screening to assess how screening results correlated with their decisions regarding amniocentesis. A 6-year review (1994-1999) of laboratory records identified 2,456 AMA patients who underwent multiple-marker ..
  98. ncbi Accuracy of the TDx-FLM assay of amniotic fluid: a comparison of vaginal pool samples with amniocentesis
    J Cleary-Goldman
    Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, New York, USA
    J Matern Fetal Neonatal Med 11:374-7. 2002
    ..The purpose of this study was to evaluate the use of the TDx-FLM fluorescence polarization assay on vaginal pool fluid in patients with preterm premature rupture of membranes (PPROM)...
  99. ncbi The diagnostic performance of cytogenetic investigation in amniotic fluid cells and chorionic villi
    F J Los
    Department of Clinical Genetics, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands
    Prenat Diagn 21:1150-8. 2001
    First-trimester chorionic villus sampling has not reached the popularity of second-trimester amniocentesis in prenatal cytogenetic diagnosis, in contrast to initial expectations...
  100. ncbi Health-related quality-of-life assessment of prenatal diagnosis: chorionic villi sampling and amniocentesis
    David Feeny
    Institute of Health Economics, Edmonton, Alberta, Canada
    Genet Test 6:39-46. 2002
    ..study assesses the health-related quality-of-life (HRQL) effects of chorionic villi sampling (CVS) and genetic amniocentesis (GA), including both process and outcomes of prenatal diagnosis...
  101. ncbi Comparison of the use of amniocentesis in two countries with different policies for prenatal testing: the case of France and the United States
    Babak Khoshnood
    Epidemiological Research Unit on Perinatal and Women s Health, INSERM U149, France
    Prenat Diagn 25:14-9. 2005
    To compare maternal age- and education-specific use of amniocentesis in France and the United States.

Research Grants62

  1. F.nucleatum in Amniotic Fluid Infection
    Yiping Han; Fiscal Year: 2004
    ..nucleatum infection in AF. AF samples will be collected via amniocentesis from 400 patients in preterm labor with intact fetal membranes at a gestational age of < 32 weeks...
  2. Non-Invasive Detection of Fetal Aneuploidy by Next-Generation DNA Sequencing
    DAVID GERARD PETERS; Fiscal Year: 2013
    ..Definitive diagnosis is then undertaken using interventional procedures such as amniocentesis and chorionic villus sampling (CVS) that obtain fetal or placental cells, respectively, for karyotype analysis...
  3. Genetic Analysis of Human First Trimester Trophoblast in Ongoing Pregnancies
    Michael Peter Diamond; Fiscal Year: 2013
    ..The most common methods of retrieving fetal tissue for prenatal diagnosis, amniocentesis and chorionic villous sampling, are invasive, with a risk of fetal loss...
  4. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..NHP AFS cell lines will be derived after amniocentesis of pregnant mothers...
  5. Non-invasive Aneuploidy Screening of Circulating Fetal Cells for Prenatal Diagnos
    Matthew Rabinowitz; Fiscal Year: 2012
    ..Although the widely used first trimester chorionic villus sampling (CVS) and second trimester amniocentesis are relatively safe, both procedures are not without negligible risks...
  6. Rapid non-invasive prenatal Down syndrome detection using a DNA-molecule counter
    Glenn Fu; Fiscal Year: 2013
    ..and blood sample measurements are inaccurate, and confirmatory tests such as chorionic villus sampling and amniocentesis are invasive procedures that can cause miscarriage...
  7. Co-Operative Multicenter Trials in Obstetrics &Maternal Fetal Medicine
    Yoram Sorokin; Fiscal Year: 2013
    ..will reduce the risk of spontaneous preterm birth (SPTB) among women that (Uu) undergo mid-trimester genetic amniocentesis for clinical indications, and have Ureaplasma urealyticum detected in amniotic fluid, by polymerase chain ..
  8. Novel Optical Technique for Recovery of Fetal Cells in Maternal Blood
    Lev T Perelman; Fiscal Year: 2012
    Project Summary Present cell-based techniques of prenatal diagnosis such as amniocentesis, chorionic villus sampling (CVS) and percutaneous umbilical blood sampling (PUBS) are invasive and present significant risks of fetal loss...
  9. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    ROBERT DESNICK; Fiscal Year: 1990
    ..comparing the safety and accuracy of chorionic villus sampling (CVS) in the first trimester of pregnancy with amniocentesis in the second trimester for the prenatal diagnosis of genetic disorders...
  10. PRENATAL DOWN SYNDROME SCREENING
    Rachel Fisher; Fiscal Year: 1993
    ..The risk of delivering a baby with Down syndrome (DS) increases with increasing maternal age [2]. By offering amniocentesis to women 35 and over, approximately 20% of DS pregnancies can be detected...
  11. FETAL ERYTHROID CELLS IN MATERNAL CIRCULATION
    STEPHEN GRANT; Fiscal Year: 1999
    ..Such a maternal blood test could ultimately complement, or perhaps even replace such invasive procedures as amniocentesis and chorionic villus sampling...
  12. IN SITU HYBRIDIZATION IN PRENATAL DIAGNOSIS
    Kenneth Castleman; Fiscal Year: 1993
    ..techniques for detecting the most commonly occurring cytogenetic abnormalities in interphase cells obtained by amniocentesis or chorionic villus sampling (CVS)...
  13. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    Eugene Pergament; Fiscal Year: 1990
    ..overall aim of this proposal is to compare the safety and the accuracy of Chorionic Villi Sampling (CVS) with amniocentesis by means of a multicenter, cooperative clinical study...
  14. Miniature Laser Therapy Endoscope
    Guillermo Tearney; Fiscal Year: 2009
    ..of our device will be 350 [unreadable]m, small enough to be introduced into the amniotic cavity through an amniocentesis needle (22-gauge), which should provide a 10-fold reduction in complication rate...
  15. EVALULATION OF PRENATAL TESTS FOR CHROMOSOMAL DISORDERS
    A Washington; Fiscal Year: 1993
    ..of the appropriate clinical use of prenatal diagnostic tests for chromosomal abnormalities, focusing on amniocentesis and chorionic villus sampling (CVS)...
  16. IMPROVED CLASSIFIERS FOR AUTOMATED MULTIPLEX FISH
    Kenneth Castleman; Fiscal Year: 2001
    ..fully and test the system in routine clinical use on prenatal, postnatal and cancer specimens from amniocentesis, peripheral blood, and bone marrow...
  17. Holographic Sonic Flashlighlt for Guiding Interventional Procedures
    George Stetten; Fiscal Year: 2009
    ..Thus certain ultrasound-guided procedures such as liver biopsy and amniocentesis are not practical with the SF, because attaching such a large display would make a hand-held transducer ..
  18. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    David Ledbetter; Fiscal Year: 1990
    b>Amniocentesis for prenatal diagnosis is currently utilized by 30 to 40 percent of women becoming pregnant over age 35. It's safety and accuracy are well documented. However, it can not be performed until 16 weeks gestation...
  19. The demographic trajectory of the sex ratio in human pregnancy
    STEVEN ORZACK; Fiscal Year: 2009
    ..the sex ratio at a defined time just after conception, 2) analyze data from chorionic-villus sampling and from amniocentesis in order to make accurate estimates of the sex ratio at well-defined times later during pregnancy, 3) analyze ..
  20. RANDOMIZED TRIAL OF 11-14 WEEK AMNIOCENTESIS AND TA CVS
    Elizabeth Thom; Fiscal Year: 1999
    This application accompanies a proposal entitled "Randomized Trial of 11-14 Week Amniocentesis and TA CVS" submitted by Dr. Laird Jackson leading a group of twelve clinical centers...
  21. Improved Classifiers for Multiplex FISH
    Kenneth Castleman; Fiscal Year: 2004
    ..fully and test the system in routine clinical use on prenatal, postnatal and cancer specimens from amniocentesis, peripheral blood, and bone marrow...
  22. SCANNING CYTOMETRY TO SORT FETAL NRBCS IN MATERNAL BLOOD
    Jeffrey Price; Fiscal Year: 2002
    ..Genetic anomalies are to be detected by ultrasound, amniocentesis and chorionic villus sampling...
  23. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    Joe Simpson; Fiscal Year: 1990
    ..After randomization into two groups (chorionic villus sampling vs amniocentesis), we will detail medical history, prior pregnancies, genetic history and socioeconomic factors (Forms B,C,D)...
  24. EVALUATING A DECISION TOOL FOR PRENATAL TESTING
    Miriam Kuppermann; Fiscal Year: 2002
    ..testing for fetal chromosomal abnormalities, including maternal serum screening, chorionic villus sampling, amniocentesis, ultrasonography and no testing...
  25. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    Maurice Mahoney; Fiscal Year: 1990
    ..20 per month for 2-1/2 years who will accept randomization of their diagnostic procedure between CVB and amniocentesis. These women, through the cooperation of their obstetricians, will be identified by the eighth week of ..
  26. ISOLATION OF HUMAN FETAL CELLS FROM MATERNAL BLOOD
    James Leary; Fiscal Year: 1992
    ..Such cells could be obtained as early as the first 8-10 weeks of pregnancy and, unlike chorion villus and amniocentesis assays, represents no risk to either mother or fetus...
  27. Development Psychopharmacology
    DONALD NEWPORT; Fiscal Year: 2005
    ..milk and serum of nursing infants, and prenatal exposure via collection of amniotic fluid in the event of amniocentesis. Pediatric records will be obtained annually to monitor child developmental milestones...
  28. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    MITCHELL GOLBUS; Fiscal Year: 1990
    ..Detection of genetic defects by amniocentesis has made significant contributions to medical genetics, but chorionic villus biopsy may offer access to ..
  29. RECOVERY OF FETAL CELLS IN MATERNAL BLOOD
    DAVID SAMMONS; Fiscal Year: 1999
    ..pregnancy can be recovered by charge flow separation (CFS), a method that obviates the risks associated with amniocentesis and chorionic villus sampling...
  30. PRENATAL INFECTION, BRAIN DEVELOPMENT AND SCHIZOPHRENIA
    John Gilmore; Fiscal Year: 2003
    ..A clinical study of amniotic fluid obtained at amniocentesis from human pregnancies with and without prior exposure to infection will be used to determine cytokine and ..
  31. PRENATAL DIAGNOSIS TRIALS--FETAL CELLS/MATERNAL BLOOD
    Lee Shulman; Fiscal Year: 2000
    ..The results of these peripheral blood studies will be compared to those that will be obtained from amniocentesis or chorionic villus sampling (CVS) on the same women...
  32. PRENATAL DIAGNOSIS TRIALS--FETAL CELLS/MATERNAL BLOOD
    DIANA BIANCHI; Fiscal Year: 2000
    ..The results of these peripheral blood studies will be compared to those that will be obtained from amniocentesis or chorionic villus sampling (CVS) on the same women...
  33. PRENATAL DIAGNOSIS TRIALS--FETAL CELLS/MATERNAL BLOOD
    Mark Evans; Fiscal Year: 2000
    ..The results of these peripheral blood studies will be compared to those that will be obtained from amniocentesis or chorionic villus sampling (CVS) on the same women...
  34. PRENATAL DIAGNOSIS TRIALS--FETAL CELLS/MATERNAL BLOOD
    Laird Jackson; Fiscal Year: 2000
    ..The results of these peripheral blood studies will be compared to those that will be obtained from amniocentesis or chorionic villus sampling (CVS) on the same women...
  35. COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS
    Laird Jackson; Fiscal Year: 1990
    ..undergoing amniocentesis at 16 weeks...
  36. MULTI-MEDIA TRAINING IN CYTOTECHNOLOGY
    Bruce Cameron; Fiscal Year: 1993
    ..in identification of the most commonly occurring cytogenetic abnormalities in metaphase cells obtained by amniocentesis or chorionic villus sampling...
  37. Diagnostic proteomic profiles for aneuploidy
    Ashok Reddy; Fiscal Year: 2004
    ..aneuploidies follows a two-step process: maternal screening and, if the results are positive, maternal amniocentesis with fetal karotyping. There are significant limitations to both first- and second-semester screening tests...
  38. Diagnostic proteomic profiles for aneuploidy
    Srinivasa Nagalla; Fiscal Year: 2006
    ..DS) currently involves suggestive serum tests that are subsequently validated by invasive procedures such as amniocentesis or chorionic villus sampling...
  39. ULTRASONIC EVALUATION OF FETAL LUNG MATURITY
    PAUL CARSON; Fiscal Year: 1990
    ..dates of maturation or potential to respond to glucocorticoid treatment is quite limited and the necessary amniocentesis is an invasive procedure...
  40. HIV TRANSMISSION IN NEWBORNS: STUDY IN PREGNANT
    Donald Craven; Fiscal Year: 1991
    ..fluid will also be cultured and examined for HIV antigen in women who are having a clinically indicated amniocentesis, a caesarian section, or who have not ruptured the amniotic membranes prior to delivery...
  41. Comprehensive non-invasive prenatal diagnostics
    Eugene Pergament; Fiscal Year: 2004
    ..g., amniocentesis, chroionic villus sampling) may become a new standard of care...
  42. Differential Gene expression in Down Syndrome Placentae
    Susan Gross; Fiscal Year: 2003
    ..Thus, when patients are screen positive, they are offered amniocentesis to confirm the suspicion of fetal DS...
  43. Exploiting a Cytochemical AND Gate in Hematology
    Alex Saunders; Fiscal Year: 2002
    ..A decrease in amniocentesis means a potential savings of $1.61313 to the US health care system.
  44. An Interactive Informed Consent and Education Program for Pregnant Women
    Robert Levine; Fiscal Year: 2009
    ..In Phase I, we will prototype an interactive informed consent/patient education program for amniocentesis. We have teamed with Northwestern University to develop and evaluate this program and establish proof of ..
  45. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  46. GENETIC COUNSELING STRATEGIES WITH MEXICAN-ORIGIN WOMEN
    Carole Browner; Fiscal Year: 2002
    ..abstract_text> ..
  47. Use of Genetics in Neurologists' Clinical Practices
    Carole Browner; Fiscal Year: 2006
    ..abstract_text> ..
  48. ALLOIMMUNIZATION TO PATERNAL LEUKOCYTES FOR HDN
    Kenneth Moise; Fiscal Year: 2002
    ..A monocyte monolayer assay will be performed using the spleens and sensitized red cells of the pups from the three serial breedings to determine the level of phagocytosis of the fetal reticuloendothelial system. ..
  49. Expanded Prenatal Testing Options and Informed Choice
    Miriam Kuppermann; Fiscal Year: 2010
    ..In short, this study will generate a useful decision-assisting tool and provide information for use in designing cost-effective testing programs that allow for variation in preferences. ..
  50. Intermediate Outcomes of Hysterectomy and Alternatives
    Miriam Kuppermann; Fiscal Year: 2006
    ..abstract_text> ..
  51. DNA Patent Policies at Academic Institutions
    LeRoy Walters; Fiscal Year: 2003
    ..S. and Canadian academic institutions. ..
  52. Testing Pharmacological Therapies for Pregnant Smokers
    Kathryn Pollak; Fiscal Year: 2006
    ..Moreover, the study results have immediate potential to inform clinical recommendations for integrating nicotine replacement into prenatal care. ..
  53. Outcomes in congenital toxoplasmic retinochoroiditis
    Ruth Gilbert; Fiscal Year: 2005
    ..abstract_text> ..
  54. Thyroid Hormone Receptor Isoforms & Coactivators In Vivo
    Roy Weiss; Fiscal Year: 2005
    ..Such information would generate important leads in understanding the specific mechanistic aspects of TH action. ..
  55. Clinical Phenotype of Imprinted Genes of Chromosome 14
    Vernon Sutton; Fiscal Year: 2005
    ..This phenotype delineation will lay the foundation for understanding the effects and pathogenesis of imprinted genes on chromosome 14. ..
  56. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..Women with the indication of AMA, who are referred to Mount Sinai Medical Center for a routine screening amniocentesis, will be recruited...
  57. COOPERATIVE MULTI CENTER REPRODUCTIVE MEDICINE NETWORK
    Evan Myers; Fiscal Year: 2005
    ..abstract_text> ..
  58. PROGRAM PROJECT GRANT
    Jouni Uitto; Fiscal Year: 2006
    ..abstract_text> ..
  59. Nuclear cofactors in Human Thyroid Disease
    Roy Weiss; Fiscal Year: 2007
    ..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..