tracheostomy

Summary

Summary: Surgical formation of an opening into the trachea through the neck, or the opening so created.

Top Publications

  1. doi Endobrochial blockade through a tracheostomy tube for lung isolation
    George Vretzakis
    Department of Anesthesiology, University Hospital of Larissa, Greece
    Anesth Analg 107:1644-5. 2008
  2. ncbi Ultrasound-guided percutaneous dilatational tracheostomy: a safe method to avoid cranial misplacement of the tracheostomy tube
    A Sustic
    Department of Anaesthesiology and ICU, University Hospital Rijeka, Croatia
    Intensive Care Med 26:1379-81. 2000
  3. ncbi Percutaneous tracheostomy: ciaglia blue rhino versus the basic ciaglia technique of percutaneous dilational tracheostomy
    C Byhahn
    Department of Anesthesiology, Intensive Care Medicine and Pain Control, J W Goethe University Hospital, Frankfurt, Germany
    Anesth Analg 91:882-6. 2000
  4. doi Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial
    Duncan Young
    Adult Intensive Care Unit, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, England
    JAMA 309:2121-9. 2013
  5. ncbi [Analysis of early tracheostomy and its impact on development of pneumonia, use of resources and mortality in neurocritically ill patients]
    F Gandía-Martínez
    Servicio de Medicina Intensiva, Hospital Clinico Universitario de Valladolid
    Neurocirugia (Astur) 21:211-21. 2010
  6. ncbi Mandibular distraction in neonates: a strategy to avoid tracheostomy
    Arlen Denny
    Medical College of Wisconsin, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Plast Reconstr Surg 109:896-904; discussion 905-6. 2002
  7. ncbi A new simple method for percutaneous tracheostomy: controlled rotating dilation. A preliminary report
    G Frova
    Department of Anaesthesia and Intensive Care, Spedali Civili Brescia, Brescia, Italy
    Intensive Care Med 28:299-303. 2002
  8. ncbi Cricoid palpability as a selection criterion for bedside tracheostomy
    Omar F Husein
    Department of Otolaryngology, The Ohio State University, Columbus, OH, USA
    Otolaryngol Head Neck Surg 133:839-44. 2005
  9. ncbi The incidence of tracheoarterial fistula in patients with chronic tracheostomy tubes: a retrospective study of 544 patients in a long-term care facility
    Paul Scalise
    Department of Pulmonary Medicine, Hospital for Special Care, 2150 Corbin Ave, New Britain, CT 06053, USA
    Chest 128:3906-9. 2005
  10. ncbi Indications, timing, and techniques of tracheostomy in 152 French ICUs
    François Blot
    Service de Reanimation Polyvalente, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Chest 127:1347-52. 2005

Detail Information

Publications356 found, 100 shown here

  1. doi Endobrochial blockade through a tracheostomy tube for lung isolation
    George Vretzakis
    Department of Anesthesiology, University Hospital of Larissa, Greece
    Anesth Analg 107:1644-5. 2008
    We present an alternative technique for one-lung ventilation as safe way of treating patients with tracheostomy using a fiberoptic bronchoscope and a Fogarty catheter.
  2. ncbi Ultrasound-guided percutaneous dilatational tracheostomy: a safe method to avoid cranial misplacement of the tracheostomy tube
    A Sustic
    Department of Anaesthesiology and ICU, University Hospital Rijeka, Croatia
    Intensive Care Med 26:1379-81. 2000
    ..The aim of this investigation was to evaluate the role of ultrasonography in avoiding cranial misplacement of the tracheostomy tube and tracheal ring fractures during percutaneous dilatational tracheostomy (PDT)...
  3. ncbi Percutaneous tracheostomy: ciaglia blue rhino versus the basic ciaglia technique of percutaneous dilational tracheostomy
    C Byhahn
    Department of Anesthesiology, Intensive Care Medicine and Pain Control, J W Goethe University Hospital, Frankfurt, Germany
    Anesth Analg 91:882-6. 2000
    Percutaneous dilational tracheostomy (PDT), according to Ciaglia's technique described in 1985, has become the most popular technique for percutaneous tracheostomy and is demonstrably as safe as surgical tracheostomy...
  4. doi Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial
    Duncan Young
    Adult Intensive Care Unit, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, England
    JAMA 309:2121-9. 2013
    b>Tracheostomy is a widely used intervention in adult critical care units. There is little evidence to guide clinicians regarding the optimal timing for this procedure.
  5. ncbi [Analysis of early tracheostomy and its impact on development of pneumonia, use of resources and mortality in neurocritically ill patients]
    F Gandía-Martínez
    Servicio de Medicina Intensiva, Hospital Clinico Universitario de Valladolid
    Neurocirugia (Astur) 21:211-21. 2010
    We analyze the most suitable time to perform tracheostomy in neurocritically ill patients...
  6. ncbi Mandibular distraction in neonates: a strategy to avoid tracheostomy
    Arlen Denny
    Medical College of Wisconsin, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Plast Reconstr Surg 109:896-904; discussion 905-6. 2002
    ..past 5 years, the authors developed an application of mandibular distraction osteogenesis to eliminate existing tracheostomy. That experience led the authors to attempt mandibular distraction osteogenesis in neonates as an alternative ..
  7. ncbi A new simple method for percutaneous tracheostomy: controlled rotating dilation. A preliminary report
    G Frova
    Department of Anaesthesia and Intensive Care, Spedali Civili Brescia, Brescia, Italy
    Intensive Care Med 28:299-303. 2002
    To describe and introduce a new technique for percutaneous dilational tracheostomy.
  8. ncbi Cricoid palpability as a selection criterion for bedside tracheostomy
    Omar F Husein
    Department of Otolaryngology, The Ohio State University, Columbus, OH, USA
    Otolaryngol Head Neck Surg 133:839-44. 2005
    To prospectively evaluate the significance of cricoid cartilage palpability as a selection criterion for bedside tracheostomy and to prospectively compare a cohort of patients undergoing bedside tracheostomy with another cohort receiving ..
  9. ncbi The incidence of tracheoarterial fistula in patients with chronic tracheostomy tubes: a retrospective study of 544 patients in a long-term care facility
    Paul Scalise
    Department of Pulmonary Medicine, Hospital for Special Care, 2150 Corbin Ave, New Britain, CT 06053, USA
    Chest 128:3906-9. 2005
    The incidence of tracheoarterial fistula (TAF) in patients with short-term tracheostomy tubes has been reported between 0.6% and 0.7%...
  10. ncbi Indications, timing, and techniques of tracheostomy in 152 French ICUs
    François Blot
    Service de Reanimation Polyvalente, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Chest 127:1347-52. 2005
    To investigate the current practice of tracheostomy in French ICUs, focusing on the frequency, timing, indications, and techniques.
  11. doi Fiberoptic bronchoscopy-assisted percutaneous tracheostomy is safe in obese critically ill patients: a prospective and comparative study
    Carlos M Romero
    Critical Care Unit, University of Chile Clinical Hospital, Santiago Norte, Chile
    J Crit Care 24:494-500. 2009
    ..In Latin America, 10% to 35% of the population is obese. Obese critically ill patients are at greater risk for requiring intubation and prolonged mechanical ventilation; and in some cases, it is necessary to perform a tracheostomy.
  12. ncbi [Difficult airway management during emergency tracheostomy in a patient with severe rheumatoid arthritis]
    Noriko Yonemoto
    Department of Anesthesia, Bellland General Hospital, Sakai 599 8247
    Masui 54:39-41. 2005
    ..Her cervical spine was ankylosed and could not be extended at all. Tracheostomy was planned under local anesthesia because of difficulty of endotracheal intubation, possibility of airway ..
  13. ncbi Should tracheostomy be performed as early as 72 hours in patients requiring prolonged mechanical ventilation?
    Charles G Durbin
    Department of Anesthesiology, University of Virginia Health Science Center, Charlottesville, Virginia 22908 0170, USA
    Respir Care 55:76-87. 2010
    ..If intubation is projected to be longer than several weeks, tracheostomy is often recommended...
  14. pmc Early and late outcome after single step dilatational tracheostomy versus the guide wire dilating forceps technique: a prospective randomized clinical trial
    Bernard G Fikkers
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, P O Box 9600, 6500 HB, Nijmegen, The Netherlands
    Intensive Care Med 37:1103-9. 2011
    Percutaneous tracheostomy is frequently performed in long-term ventilated patients in the intensive care unit (ICU)...
  15. ncbi MDCT of the central airways: comparison with bronchoscopy in the evaluation of complications of endotracheal and tracheostomy tubes
    Maryellen Sun
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Thorac Imaging 22:136-42. 2007
    To evaluate the accuracy of multidetector row computed tomography (MDCT) compared with bronchoscopy in the assessment of airway complications related to endotracheal and tracheostomy tubes.
  16. ncbi Utilization of tracheostomy in craniomaxillofacial trauma at a level-1 trauma center
    Eric P Holmgren
    Department of Oral and Maxillofacial Surgery, Oregon Health and Science University, Portland, OR, USA
    J Oral Maxillofac Surg 65:2005-10. 2007
    The decision to perform a tracheostomy on patients with maxillofacial trauma is complex. There is little data exploring the role of tracheostomy in facial fracture management...
  17. pmc Timing of tracheostomy as a determinant of weaning success in critically ill patients: a retrospective study
    Chia Lin Hsu
    Division of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Crit Care 9:R46-52. 2005
    b>Tracheostomy is frequently performed in critically ill patients for prolonged intubation...
  18. doi The effect of tracheostomy timing during critical illness on long-term survival
    Damon C Scales
    Department of Critical Care, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada
    Crit Care Med 36:2547-57. 2008
    b>Tracheostomy is common in intensive care unit patients, but the appropriate timing is controversial.
  19. doi Bedside ultrasound screening for pretracheal vascular structures may minimize the risks of percutaneous dilatational tracheostomy
    Alexander C Flint
    Neurocritical Care and Pulmonary Critical Care, Head and Neck Surgery, Kaiser Permanente, 1150 Veterans Blvd, Redwood City, CA 94063, USA
    Neurocrit Care 11:372-6. 2009
    Percutaneous dilatational tracheostomy (PDT) continues to gain in popularity as a bedside method for tracheostomy placement in the intensive care unit...
  20. ncbi Tracheotomy: clinical review and guidelines
    Paul De Leyn
    Department of Thoracic Surgery, University Hospital Leuven, Belgium
    Eur J Cardiothorac Surg 32:412-21. 2007
    ..PDT should be considered the procedure of choice in elective non-urgent tracheotomy. There are some relative contraindications for PDT, but with growing experience, they become less frequent...
  21. ncbi A prospective, randomized study comparing percutaneous with surgical tracheostomy in critically ill patients
    B D Freeman
    Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA
    Crit Care Med 29:926-30. 2001
    OBJECTIVE: To determine the relative cost-effectiveness of percutaneous dilational tracheostomy (PDT) and surgical tracheostomy (ST) in critically ill patients. DESIGN: Prospective randomized study...
  22. ncbi Tracheo-innominate artery fistula after percutaneous tracheostomy: three case reports and a clinical review
    C A Grant
    Critical Care Unit, University Hospital, Aintree, Liverpool, UK
    Br J Anaesth 96:127-31. 2006
    Tracheo-innominate artery fistula (TIF) is an uncommon yet life threatening complication after a tracheostomy. Rates of 0.1-1% after surgical tracheostomy have been reported, with a peak incidence at 7-14 days post procedure...
  23. doi Tracheostomy in patients with long-term mechanical ventilation: a survey
    Santino Marchese
    Respiratory Intensive Care Unit, Terapia Intensiva Respiratoria, Ospedale Civico, ARNAS, Via C Lazzaro, Palermo, Italy
    Respir Med 104:749-53. 2010
    b>Tracheostomy is increasingly performed in intensive care units (ICU), with many patients transferred to respiratory ICU (RICU). Indications/timing for closing tracheostomy are discussed.
  24. doi Neurologic examination and extubation outcome in the neurocritical care unit
    Christopher D Anderson
    Neurocritical Care Service, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Neurocrit Care 15:490-7. 2011
    ..Extubation failure in the neurocritical care unit (NCCU) is difficult to predict, and is an important source of prolonged intensive care, exposure to morbidity, and increased cost...
  25. doi Tracheostomy decannulation failure rate following critical illness: a prospective descriptive study
    Kim Choate
    The Alfred, Commercial Road, Prahran, Victoria 3181, Australia
    Aust Crit Care 22:8-15. 2009
    b>Tracheostomy is a well established and practical approach to airway management for patients requiring extended periods of mechanical ventilation or airway protection...
  26. doi Early tracheostomy decreases ventilation time but has no impact on mortality of intensive care patients: a randomized study
    Tillo Koch
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Gießen, Rudolf Buchheim Straße 7, Giesen, Germany
    Langenbecks Arch Surg 397:1001-8. 2012
    ..While the influence of tracheostomy on VAP incidence, duration of ventilation, and time of hospitalization has already been analyzed in several ..
  27. ncbi Percutaneous dilational tracheostomy: an initial experience in community based teaching hospital
    S Joshi
    Department of Anaesthesiology and Critical Care, B P Koirala Institute of Health Sciences, Dharan, Nepal
    Kathmandu Univ Med J (KUMJ) 4:275-80. 2006
    Percutaneous dilational tracheostomy (PDT) is frequently performed in the intensive care unit to prevent the long term complications associated with prolonged endotracheal intubation.
  28. doi Tracheostomy in critically ill patients
    Abhiram Mallick
    Leeds General Infirmary, Leeds, UK
    Eur J Anaesthesiol 27:676-82. 2010
    b>Tracheostomy is performed in about a quarter of ICU patients requiring prolonged mechanical ventilation, weaning from assisted ventilation, airway suction and airway protection...
  29. doi Amelioration of pathological yawning after tracheostomy in a patient with locked-in syndrome
    C C Chang
    Eur J Neurol 15:e66-7. 2008
  30. ncbi Tracheostomy decannulation: implication on respiratory mechanics
    Dominic Dellweg
    Fachkrankenhaus Kloster Grafschaft, Annostr 1, 57392 Schmallenberg, Germany
    Head Neck 29:1121-7. 2007
    b>Tracheostomy decreases airway resistance and work of breathing. No comprehensive data are available on respiratory mechanics after tracheostomy decannulation. We evaluated respiratory mechanics after decannulation.
  31. doi Decannulation following tracheostomy for prolonged mechanical ventilation
    Heidi H O'Connor
    Pulmonary and Sleep Division, New England Sinai Hospital, Stoughton, MA 02072, USA
    J Intensive Care Med 24:187-94. 2009
    We examined the process of decannulation following tracheostomy in patients transferred to a long-term acute care (LTAC) hospital for weaning from prolonged mechanical ventilation (PMV).
  32. pmc An intensivist-led tracheostomy review team is associated with shorter decannulation time and length of stay: a prospective cohort study
    Antony E Tobin
    Intensive Care Unit, St, Vincent s Hospital Melbourne, PO Box 2900, Fitzroy VIC 3065, Australia
    Crit Care 12:R48. 2008
    Without specific strategies to address tracheostomy care on the wards, patients discharged from the intensive care unit (ICU) with a tracheostomy may receive suboptimal care...
  33. doi Predictors of successful decannulation using a tracheostomy retainer in patients with prolonged weaning and persisting respiratory failure
    Stephan Budweiser
    Division of Pulmonary and Respiratory Medicine, Department of Internal Medicine III, RoMed Clinical Center Rosenheim, Rosenheim, Germany
    Respiration 84:469-76. 2012
    ..For percutaneously tracheostomized patients with prolonged weaning and persisting respiratory failure, the adequate time point for safe decannulation and switch to noninvasive ventilation is an important clinical issue...
  34. ncbi The long-term evaluation of tracheostomy in the management of severe obstructive sleep apnea
    Gentry W Thatcher
    Department of Otolaryngology, Hennepin County Medical Center and the University of Minnesota, Minneapolis, Minnesota 55415, USA
    Laryngoscope 113:201-4. 2003
    ..To determine the long-term success and morbidity of tracheostomies for patients with severe obstructive sleep apnea...
  35. ncbi A North American survey of respiratory therapist and physician tracheostomy decannulation practices
    Henry Thomas Stelfox
    Department of Critical Care Medicine, University of Calgary, Foothills Medical Centre EG23A, 1403 29 Street NW, Calgary, Alberta T2N 2T9 Canada
    Respir Care 54:1658-64. 2009
    b>Tracheostomy is a common surgical procedure performed on critically ill patients...
  36. ncbi Decannulation and survival following tracheostomy in an intensive care unit
    Randal Leung
    Department of Head and Neck Surgery and Otolaryngology, Royal Melbourne Hospital, Parkville, Australia
    Ann Otol Rhinol Laryngol 112:853-8. 2003
    We investigated the long-term outcome of patients requiring tracheostomy in an intensive care unit (ICU) in an attempt to identify risk factors that would indicate a low probability of early decannulation...
  37. pmc Determinants of tracheostomy decannulation: an international survey
    Henry Thomas Stelfox
    Department of Critical Care Medicine, University of Calgary, Foothills Medical Centre, EG23A, 1403 29 Street NW, Calgary, AB, Canada, T2N 2T9
    Crit Care 12:R26. 2008
    Although tracheostomy is probably the most common surgical procedure performed on critically ill patients, it is unknown when a tracheostomy tube can be safely removed.
  38. ncbi [Mechanical ventilation of weaning interruption]
    Rosane Goldwasser
    J Bras Pneumol 33:S128-36. 2007
  39. pmc Survey of use of the insufflator-exsufflator in patients with spinal cord injury
    James K Schmitt
    Department of Internal Medicine, H H McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23113, USA
    J Spinal Cord Med 30:127-30. 2007
    ..However, many institutions do not use this device. The study was performed to assess use of the device and attitudes among health care providers...
  40. pmc Rapid reduction of antihypertensive medications and insulin requirements after tracheostomy in a patient with severe obstructive sleep apnea syndrome
    Arvind Bhimaraj
    Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA
    J Clin Sleep Med 3:297-9. 2007
    ..sleep apnea syndrome, diabetes mellitus, and hypertension, with postoperative complications following tracheostomy. His stormy postoperative course is presented with emphasis on glycemic control and hypertension...
  41. doi Stroke-related Early Tracheostomy versus Prolonged Orotracheal Intubation in Neurocritical Care Trial (SETPOINT): a randomized pilot trial
    Julian Bösel
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg D 69121, Germany
    Stroke 44:21-8. 2013
    Optimal timing of tracheostomy in ventilated patients with severe stroke is unclear. We aimed to investigate feasibility, safety, and potential advantages of early tracheostomy in these intensive care unit (ICU) patients.
  42. doi Incidence and clinical predictors for tracheostomy after cervical spinal cord injury: a National Trauma Databank review
    Bernardino C Branco
    Division of Trauma and Surgical Critical Care, University of Southern California, Los Angeles, California 90033, USA
    J Trauma 70:111-5. 2011
    The purpose of this study was to determine the incidence and identify clinical predictors for the need for tracheostomy after cervical spinal cord injury (CSCI).
  43. ncbi The use of cognitive task analysis to improve the learning of percutaneous tracheostomy placement
    Maura E Sullivan
    Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Am J Surg 193:96-9. 2007
    The purpose of the current study was to determine the effectiveness of using cognitive task analysis (CTA) to develop a curriculum to teach the behavioral skills and the cognitive strategies of a percutaneous tracheostomy (PT) placement.
  44. doi Tracheostomy as treatment for adult obstructive sleep apnea: a systematic review and meta-analysis
    Macario Camacho
    Department of Otolaryngology Head and Neck Surgery, Sleep Surgery Division, Stanford University Medical Center, Stanford, California, U S A
    Laryngoscope 124:803-11. 2014
    To systematically review outcomes for polysomnography, sleepiness, and mortality in patients who undergo tracheostomy for the treatment of adult obstructive sleep apnea (OSA).
  45. doi Definitive establishment of airway control is critical for optimal outcome in lower cervical spinal cord injury
    Victor J Hassid
    Department of Surgery, University of Florida Health Science Center, Jacksonville, Florida 32209, USA
    J Trauma 65:1328-32. 2008
    ..This study sought to determine the incidence and effect of catastrophic airway loss (CLA) and to define the need for elective intubation with subsequent tracheostomy to prevent potentially fatal outcomes.
  46. ncbi Early versus late percutaneous dilational tracheostomy in critically ill patients anticipated requiring prolonged mechanical ventilation
    Yue Zheng
    Department of Surgical Intensive Care Unit, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Chin Med J (Engl) 125:1925-30. 2012
    b>Tracheostomy should be considered to replace endotracheal intubation in patients requiring prolonged mechanical ventilation (MV). However, the optimal timing for tracheostomy is still a topic of debate...
  47. doi Performance of the coughassist insufflation-exsufflation device in the presence of an endotracheal tube or tracheostomy tube: a bench study
    Claude Guerin
    Service de Réanimation Médicale et d Assistance Respiratoire, Hopital de la Croix Rousse, Lyon, France
    Respir Care 56:1108-14. 2011
    ..The device may benefit intubated and tracheotomized patients. We assessed the impact of various artificial airways on peak expiratory flow (PEF) with the CoughAssist...
  48. ncbi Tracheostomy after anterior cervical spine fixation
    Terence O'Keeffe
    Department of Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 57:855-60. 2004
    Patients with cervical spine injury may require both anterior cervical spine fusion and tracheostomy, particularly in the setting of associated cervical spinal cord injury (SCI)...
  49. ncbi The influence of long-term tracheostomy on speech and language development in children
    D Jiang
    Department of Otolaryngology, Head and Neck Surgery, Guy s Hospital, London, UK
    Int J Pediatr Otorhinolaryngol 67:S217-20. 2003
    ..With no coexisting neurological impairment, some suggested that tracheostomy has little influence on speech development, whilst others showed a clear pattern of language disability...
  50. doi Diaphragmatic rupture due to violent cough during tracheostomy
    Hiroshi Nakanishi
    Department of Otolaryngology, Hamamatsu University School of Medicine, Handayama, and Hamamatsu Red Cross Hospital, Hamamatsu, Japan
    Auris Nasus Larynx 37:121-4. 2010
    We present herein a rare case of diaphragmatic rupture due to violent coughing during tracheostomy. A 73-year-old man was admitted with cough, hoarseness and dysphagia caused by a huge laryngeal cancer obstructing the airways...
  51. ncbi Early tracheostomy does not improve outcome in burn patients
    Jeffrey R Saffle
    Department of Surgery and the Intermountain Burn Center, University of Utah Health Center, Salt Lake City, Utah 84132, USA
    J Burn Care Rehabil 23:431-8. 2002
    Early tracheostomy (ET) has been claimed to reduce ventilator support or intensive care unit or hospital length of stay in intensive care unit patients. This study was performed to assess the potential benefits of ET in burn patients...
  52. pmc Bench-to-bedside review: early tracheostomy in critically ill trauma patients
    Nehad Shirawi
    Intensive Care Department, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
    Crit Care 10:201. 2006
    A significant proportion of trauma patients require tracheostomy during intensive care unit stay. The timing of this procedure remains a subject of debate...
  53. pmc Characterizing the need for tracheostomy placement and decannulation after cervical spinal cord injury
    Hiroaki Nakashima
    Department of Orthopaedic Surgery, Nagoya University Hospital, Graduate School of Medicine, 65 Tsurumai, Shouwa ku, Nagoya, Aichi 466 8560, Japan
    Eur Spine J 22:1526-32. 2013
    There have been few reports on the risk factors for tracheostomy and the possibility of patients for decannulation...
  54. doi Long-term azithromycin use in patients with chronic obstructive pulmonary disease and tracheostomy
    Francesco Blasi
    Dipartimento Toraco polmonare e Cardio circolatorio, University of Milan, IRCCS Fondazione Po Ma Re, Milan, Italy
    Pulm Pharmacol Ther 23:200-7. 2010
    Patients with Chronic Obstructive Pulmonary Disease (COPD) and tracheostomy are at high risk for exacerbations and hospitalizations. Macrolide treatment has shown to reduce exacerbations in moderate-to-severe COPD...
  55. ncbi Closure of laryngotracheal cavity and tracheostomy for intractable aspiration secondary to radiation encephalopathy or radiation damage of cranial nerve after radiotherapy of nasopharyngeal carcinoma
    Shenhong Qu
    Hospital of Otorhinolaryngology, First Affiliated Hospital of Sun Yat sen University, Guangzhou, People s Republic of China
    Acta Otolaryngol 126:962-6. 2006
    Closure of the laryngotracheal cavity and tracheostomy is especially suitable for intractable aspiration secondary to radiation encephalopathy or damage of cranial nerve after radiation for nasopharyngeal carcinoma (NPC).
  56. ncbi Physiological responses during a T-piece weaning trial with a deflated tube
    Piero Ceriana
    Respiratory Intensive Care Unit, Fondazione S Maugeri, IRCCS, Istituto Scientifico di Pavia, Via Ferrata 8, 27100 Pavia, Italy
    Intensive Care Med 32:1399-403. 2006
    T-piece trials and spontaneous breathing trials through the tracheostomy tube are often used as weaning techniques...
  57. doi Timing of tracheostomy after anterior cervical spine fixation
    Ranjith Babu
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Trauma Acute Care Surg 74:961-6. 2013
    Patients with cervical spinal cord injury frequently undergo early anterior cervical spine fixation (ACSF) and tracheostomy procedures to reduce further deterioration, to reduce risk of pulmonary complications, and to improve patient ..
  58. doi The effects of increasing effective airway diameter on weaning from mechanical ventilation in tracheostomized patients: a randomized controlled trial
    Gonzalo Hernandez
    Intensive Care Unit, Hospital Infanta Sofia, Madrid, Spain
    Intensive Care Med 39:1063-70. 2013
    ..To determine the effects of deflating the tracheal cuff during disconnections from mechanical ventilation (MV) in tracheostomized patients...
  59. doi The impact of tracheostomy timing in patients with severe head injury: an observational cohort study
    Hao Kuang Wang
    Department of Neurosurgery, E Da Hospital, I Shou University, Kaohsiung, Taiwan
    Injury 43:1432-6. 2012
    A retrospective analysis of 66 adults with severe head injury admitted to the neurosurgical intensive care unit (ICU) who required tracheostomy.
  60. ncbi Role of anaerobic bacteria in infections following tracheostomy, intubation, or the use of ventilatory tubes in children
    Itzhak Brook
    Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA
    Ann Otol Rhinol Laryngol 113:830-4. 2004
    Colonization of the tracheobronchial tree with microorganisms almost always follows tracheal intubation, tracheostomy, or the use of ventilatory tubes...
  61. ncbi Results of endoscopic tracheoplasty for treating tracheostomy-related airway stenosis
    S A R Nouraei
    Clin Otolaryngol 32:471-5. 2007
    Post-tracheostomy 'lambdoid' deformity of the trachea is a specific and uncommon variant of adult post-intubation laryngotracheal stenosis, in which airway obstruction is caused by inward collapse of over-resected tracheal cartilage as a ..
  62. ncbi Study of the effectiveness of bronchial clearance in subjects with upper spinal cord injuries: examination of a rehabilitation programme involving mechanical insufflation and exsufflation
    P Pillastrini
    Department of Neurological Sciences, Rehabilitative Sciences S S D MED 48, University of Bologna, Bologna, Italy
    Spinal Cord 44:614-6. 2006
    ..Randomized controlled trial...
  63. pmc Effect of technique and timing of tracheostomy in patients with acute traumatic spinal cord injury undergoing mechanical ventilation
    Javier Romero Ganuza
    Intensive Care Unit and Internal Medicine Department, Paraplejics National Hospital, Toledo, Spain
    J Spinal Cord Med 34:76-84. 2011
    To assess the effect of timing and techniques of tracheostomy on morbidity, mortality, and the burden of resources in patients with acute traumatic spinal cord injuries (SCls) undergoing mechanical ventilation.
  64. ncbi Unaided speech in tube-free tracheostomy: The supplementary sling procedure
    Isaac Eliachar
    Department of Otolaryngology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Otolaryngol Head Neck Surg 127:213-20. 2002
    In some patients after tube-free tracheostomy, air escape hinders voice optimization. Our objective was to determine whether a supplementary sling procedure could reduce air escape and improve unaided speech and cough in these patients.
  65. doi Does acuity matter?--Optimal timing of tracheostomy stratified by injury severity
    Jason M Schauer
    Department of Public Health Sciences, Division of Biostatistics, Penn State College of Medicine, Hershey, PA 17033, USA
    J Trauma 66:220-5. 2009
    A number of conflicting studies have been conducted to analyze the relationship between the timing of tracheostomy and mortality, intensive care unit (ICU) length of stay (LOS), hospital LOS, and the incidence of pneumonia...
  66. doi Tracheostomy in amyotrophic lateral sclerosis: a 10-year population-based study in Italy
    A Chio
    ALS Centre, Department of Neuroscience, University of Torino, Torino, Italy
    J Neurol Neurosurg Psychiatry 81:1141-3. 2010
    We evaluated the clinical characteristics and outcome of tracheostomy in amyotrophic lateral sclerosis (ALS) using data from the Piemonte and Valle d'Aosta Register for ALS, a prospective epidemiological register collecting all ALS ..
  67. ncbi Respiratory care of patients with cervical spinal cord injury: a review
    Sumesh Arora
    Prince of Wales Hospital, Sydney, NSW, Australia
    Crit Care Resusc 14:64-73. 2012
    ..Prolonged mechanical ventilation and tracheostomy are often required...
  68. doi Early tracheostomy is associated with improved outcomes in patients who require prolonged mechanical ventilation after cardiac surgery
    Jagan Devarajan
    Department of General Anesthesia, Cleveland Clinic, Cleveland, OH 44195, USA
    J Am Coll Surg 214:1008-16.e4. 2012
    The best time to perform a tracheostomy in cardiac surgery patients who require prolonged postoperative mechanical ventilation remains unknown...
  69. doi External control of exhalation for cough assistance: a method for patients with glottis dysfunction and/or tracheostomy
    Sang Chul Lee
    Department of Physical Medicine and Rehabilitation, Myongji Hospital, Kwandong University College of Medicine, Koyang, Kyunggi, Korea
    Arch Phys Med Rehabil 90:1402-7. 2009
    To investigate the effectiveness of our method of assisting a cough by mimicking the functions of the glottis in patients with bulbar muscle weakness or paralysis and/or those who had a tracheostomy tube.
  70. ncbi A permanent tube-free tracheostomy in a morbidly obese patient with severe obstructive sleep apnea syndrome
    Ron Eliashar
    Department of Otolaryngology Head and Neck Surgery, Hadassah University Hospital, Jerusalem, Israel
    Isr Med Assoc J 4:1156-7. 2002
  71. pmc Comparing percutaneous tracheostomy with open surgical tracheostomy
    Irawan Susanto
    BMJ 324:3-4. 2002
  72. ncbi Airway fire due to diathermy during tracheostomy in an intensive care patient
    S A Rogers
    Department of Anaesthesia and Intensive Care, The Cardiothoracic Centre, Liverpool, UK
    Anaesthesia 56:441-3. 2001
    We describe a case of airway fire in an 83-year-old, critically ill patient. The fire occurred during a surgical tracheostomy under general anaesthesia, following ignition of the tracheal tube by diathermy...
  73. doi Montgomery T-tube placement in the treatment of benign tracheal lesions
    Angelo Carretta
    Department of Thoracic Surgery, Vita Salute San Raffaele University, San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy
    Eur J Cardiothorac Surg 36:352-6; discussion 356. 2009
    ..We retrospectively investigated Montgomery T-tube placement as an alternative or complementary treatment to surgery...
  74. ncbi Tracheal ring fracture--dislodgement after Blue Rhino percutaneous tracheostomy
    A Thomas
    Anaesthesia 58:1241. 2003
  75. ncbi Physiologic effects of open and closed tracheostomy tubes on the pharyngeal swallow
    Roxann Diez Gross
    Department of Audiology and Speech Pathology, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA
    Ann Otol Rhinol Laryngol 112:143-52. 2003
    Studies linking aspiration and dysphagia to an open tracheostomy tube exemplify the possibility that the larynx may have an influence on oropharyngeal swallow function...
  76. ncbi Early vs late tracheostomy in critical care
    Jim Down
    University College Hospital, London
    Br J Hosp Med (Lond) 70:510-3. 2009
    This article reviews the current literature and practice of tracheostomy with consideration of timing and the benefits of early tracheostomy, taking account of the results from the recent TracMan study.
  77. ncbi Comparison of open versus bedside percutaneous dilatational tracheostomy in the cardiothoracic surgical patient: outcomes and financial analysis
    Matthew D Bacchetta
    Department of Cardiothoracic Surgery, New York Presbyterian Hospital, Cornell University, New York, New York 10021, USA
    Ann Thorac Surg 79:1879-85. 2005
    The clinical and financial outcomes of a change in practice from traditional tracheostomy (open) to bedside percutaneous dilatational tracheostomies (PDT) was evaluated in patients who underwent cardiothoracic surgery.
  78. ncbi Prospective randomized trial comparing the effect of early suturing of tracheostomy sites on postoperative patient swallowing and rehabilitation
    James T Brookes
    Division of Otolaryngology Head and Neck Surgery, University of Alberta, Edmonton, Alberta
    J Otolaryngol 35:77-82. 2006
    This study was designed to evaluate the effect of tracheostomy site suturing after decannulation on swallowing rehabilitation, the incidence of postoperative complications, the length of hospital stay, and overall cost saving in patients ..
  79. ncbi Ciaglia percutaneous dilational tracheostomy. Early and late complications and follow-up
    G Gambale
    CU 118, Emergency Department, Ospedale Maggiore, Bologna, Italy
    Minerva Anestesiol 69:825-30; 830-3. 2003
    Evaluation of the safety of percutaneous dilational tracheostomy (PDT) for perioperative, early and late complications.
  80. doi Safety, efficiency, and cost-effectiveness of a multidisciplinary percutaneous tracheostomy program
    Marek A Mirski
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA
    Crit Care Med 40:1827-34. 2012
    ..Prioritizing patient safety, a tracheostomy team was created at our institution to provide bedside expertise in surgery, anesthesiology, respiratory, and ..
  81. ncbi Assessment of ventilation during the performance of elective endoscopic-guided percutaneous tracheostomy: clinical evaluation of a new method
    Fausto Ferraro
    Dipartimento di Scienze Anestesiologiche, Chirurgiche e dell Emergenza, Servizio di Terapia Intensiva, Seconda Universita degli Studi di Napoli, Naples, Italy
    Chest 126:159-64. 2004
    To evaluate the feasibility of uninterrupted translaryngeal open ventilation delivered through a pediatric, uncuffed endotracheal tube during percutaneous endoscopic tracheostomy (PET).
  82. doi Submental intubation versus tracheostomy in maxillofacial trauma patients
    Petr Schutz
    Oral and Maxillofacial Surgery Unit, Al Adan Dental Center and the Oral and Maxillofacial Surgery Department, Ministry of Health, State of Kuwait
    J Oral Maxillofac Surg 66:1404-9. 2008
    To evaluate the indications and outcomes of airway management by submental intubation or tracheostomy in patients with maxillofacial trauma, and to describe the technique of submental intubation in detail and discuss its latest refinements...
  83. ncbi Alternative to tracheostomy: submental intubation in craniomaxillofacial trauma
    Karen F Kim
    Division of Plastic Surgery, Georgetown University Medical Center, Washington, DC 20007, USA
    J Craniofac Surg 16:498-500. 2005
    ..As described by Altemir in 1986, submental intubation is a useful technique as an alternative to tracheostomy in selected trauma patients...
  84. doi Percutaneous dilatational tracheostomy: review of technique and evidence for its use
    Srinivas M Susarla
    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    J Oral Maxillofac Surg 70:74-82. 2012
    b>Tracheostomy is a technique for airway management commonly used by surgeons who care for critically ill patients...
  85. pmc Tracheostomy and mechanical ventilation weaning in children affected by respiratory virus according to a weaning protocol in a pediatric intensive care unit in Argentina: an observational restrospective trial
    Gustavo Caprotta
    Head of Pediatric Intensive Care Unit of Hospital de Trauma y Emergencia Dr Federico Abete, Malvinas Argentinas Buenos Aires, Argentina
    Ital J Pediatr 37:5. 2011
    ..Although the spontaneous breathing trials were successful, the patients failed all extubations. Therefore a tracheostomy was performed and the weaning plan was begun...
  86. ncbi Modified technique of percutaneous dilational tracheostomy in 600 cases
    Geogios Leptidis
    Emergency Department, General Hospital of Nikea Piraeus, D Mantouvalou 3, Nikea 18454, Greece
    World J Surg 26:1214-6. 2002
    b>Tracheostomy is frequently required for the treatment of critically ill patients to prevent the complications with prolonged translaryngeal intubation...
  87. ncbi Preventing bleeding complications in percutaneous tracheostomy--another role for portable ultrasound in intensive care
    D King
    Br J Anaesth 91:607; author reply 607-8. 2003
  88. ncbi Translaryngeal tracheostomy: experience of 340 cases
    Michael D Sharpe
    Department of Anesthesia, London Health Sciences Centre University Campus, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    Laryngoscope 113:530-6. 2003
    To describe the authors' initial experience with a new and innovative dilational translaryngeal tracheostomy bedside technique.
  89. ncbi Dilatative percutaneous tracheostomy during double antiplatelet therapy: two consecutive cases
    L Cabrini
    Department of Intensive Care, San Raffaele Hospital and Vita Salute University of Milan, Milan, Italy
    Minerva Anestesiol 74:565-7. 2008
    This article reports two cases of dilatative percutaneous tracheostomy performed on patients treated with double antiplatelet therapy. Both patients had cardiac arrest following myocardial infarction...
  90. ncbi Facilitating speech in the patient with a tracheostomy
    Dean R Hess
    Department of Respiratory Care, Ellison 401, Massachusetts General Hospital, 55 Fruit Street, Boston MA 02114, USA
    Respir Care 50:519-25. 2005
    A tracheostomy tube decreases the ability of the patient to communicate effectively. The ability to speak provides an important improvement in the quality of life for a patient with a tracheostomy...
  91. ncbi Percutaneous dilational tracheostomy kit: an aid to submental intubation
    Binay Kumar Biswas
    Anesth Analg 103:1055. 2006
  92. ncbi [PercuTwist dilational tracheostomy. Prospective evaluation of 54 consecutive patients]
    M Grundling
    Klinik und Poliklinik für Anästhesiologie und Intensivmedizin, Klinikum der Ernst Moritz Arndt Universität Greifswald
    Anaesthesist 53:434-40. 2004
    Percutaneous dilational tracheostomy (PDT) is considered to be an accepted method in intensive care patients. In 2002 Frova and Quintel described a method of dilation that employed controlled rotation of the PercuTwist dilational device...
  93. ncbi Percutaneous tracheostomy tube obstruction: warning
    Steven J Trottier
    Department of Critical Care Medicine, St John s Mercy Medical Center, St Louis University, Tower B 4006, 621 South New Ballas Road, St Louis, MO 63141, USA
    Chest 122:1377-81. 2002
    To determine the patency of standard and modified Portex tracheostomy tubes inserted by the percutaneous dilatational technique.
  94. ncbi Tracheostomy tube ignition during microlaryngeal surgery using diode laser: a case report
    Hsun Mo Wang
    Department of Otolaryngology, Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 22:199-202. 2006
    ..using a diode laser under general anesthesia via 60% FiO2, with an airway fire occurring at the tracheostomy tube and causing tubal damage and obstruction...
  95. doi The impact of time to tracheostomy on mechanical ventilation duration, length of stay, and mortality in intensive care unit patients
    Yaseen M Arabi
    Department of Intensive Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia
    J Crit Care 24:435-40. 2009
    This study examined the potential effects of time to tracheostomy on mechanical ventilation duration, intensive care unit (ICU), and hospital length of stay (LOS), and ICU and hospital mortality.
  96. ncbi Tracheostomy protocol compliance: herding cats?
    Linda Liu
    Crit Care Med 36:1959-60. 2008
  97. ncbi Impact of early vs. late tracheostomy on weaning: a retrospective analysis
    J Bickenbach
    Department of Intensive Care, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
    Minerva Anestesiol 77:1176-83. 2011
    Early tracheostomy has been advocated for a number of reasons. Especially in association with weaning from mechanical ventilation, it is known that an early timepoint can help patients being weaned more rapidly from the ventilator...
  98. ncbi Tracheostomy: current practice on timing, correction of coagulation disorders and peri-operative management - a postal survey in the Netherlands
    D P Veelo
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam
    Acta Anaesthesiol Scand 51:1231-6. 2007
    Several factors may delay tracheostomy. As many critically ill patients either suffer from coagulation abnormalities or are being treated with anticoagulants, fear of bleeding complications during the procedure may also delay tracheostomy...
  99. ncbi Flooding with carbon dioxide prevents airway fire induced by diathermy during open tracheostomy
    Anthony M H Ho
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, SAR
    J Trauma 63:228-31. 2007
    Open tracheostomy is commonly performed during head and neck surgery, and in critically ill patients. Diathermy-induced airway fire during tracheotomy is rare but may have grave implications...
  100. pmc Sending children home on tracheostomy dependent ventilation: pitfalls and outcomes
    E A Edwards
    Great Ormond Street Hospital for Children NHS Trust, London, UK
    Arch Dis Child 89:251-5. 2004
    ..review will enable health practitioners and local health providers to anticipate the hurdles, address the problems early, and expedite the process of discharging home children who are dependent on long term ventilation via tracheostomy.
  101. pmc Percutaneous tracheostomy in patients with severe liver disease and a high incidence of refractory coagulopathy: a prospective trial
    Georg Auzinger
    Institute of Liver Studies, Liver Intensive Care Unit, King s College Hospital, London SE5 9RS, United Kingdom
    Crit Care 11:R110. 2007
    To assess the safety of percutaneous dilational tracheostomy (PDT) performed by experienced operators in critically ill patients with liver disease and coagulopathy.

Research Grants55

  1. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..SGS and other ICU acquired laryngeal and upper airway diseases that lead to failed extubation and ultimately tracheostomy. PUBLIC HEALTH RELEVANCE: Subglottic stenosis is the most common indication for tracheostomy in critically ill ..
  2. Effectiveness of ICP Monitoring in Pediatric Traumatic Brain Injury
    TELLEN BENNETT; Fiscal Year: 2013
    ..the accuracy of database codes in the linked dataset and a proxy poor functional outcome, survival with tracheostomy and gastrostomy, by conducting a three-year prospective cohort study at a single, high volume, pediatric trauma ..
  3. Manipulating Macrophage Phenotype in Laryngeal Nerve Repair
    Jonathan Cheetham; Fiscal Year: 2013
    ..Bilateral injury to the RLN can result in potentially life- threatening airway obstruction and the need for tracheostomy. The RLN can regenerate some of its axons, but more than half of patients with paralysis require some form of ..
  4. Phase II/III Study of Arimoclomol in the Treatment of SOD1 Positive Familial?.
    Merit E Cudkowicz; Fiscal Year: 2013
    ..Secondary outcome measures include time to tracheostomy or permanent assisted ventilation, forced vital capacity, negative inspiratory force, strength, long-term ..
  5. Intra-pulmonary aerosol delivery for intubated pediatric patients
    AMIR A NAQWI; Fiscal Year: 2013
    ..improved method for intra-pulmonary drug delivery in pediatric patients who are intubated or have a tracheostomy. Currently available aerosolizing devices are limited in that only certain agents and only a small fraction (..
  6. Dysregulation of RGS2 Protein and Airway Hyperresponsiveness in Asthma
    Yaping Tu; Fiscal Year: 2013
    ..We will first determine effects of RGS2 KO on house dust mite (HDM)-induced mouse AHR using invasive tracheostomy and precision-cut lung slices...
  7. Health-care Providers Roles in Decision Making in Pediatric Palliative Care
    Savithri Nageswaran; Fiscal Year: 2013
    ..1 and 2, we will conduct in-depth, semi-structured interviews of 40 caregivers of children who have received tracheostomy or chronic mechanical ventilation...
  8. Improving Healthcare Integration for Children with Tracheostomy
    JAY GRIFFIN BERRY; Fiscal Year: 2013
    ..study the impact of an internet-based care plan application to improve healthcare integration for children with tracheostomy, and improve health outcomes for these children...
  9. REDUCING ENDOTRACHEAL TUBE INFECTION USING IGG
    JEFFREY SLUNT; Fiscal Year: 1999
    Endotracheal tubes are a common biomedical device in widespread use for anesthesiology and tracheostomy procedures and for long-term ventilation...
  10. Pulmonary Airflow Monitor in Tracheostomized Children
    MALVERN BENJAMIN; Fiscal Year: 2003
    ..high fidelity flow sensor to continuously monitor tracheal gas flow in infants and young children who require a tracheostomy tube for relief of airway obstruction or chronic respiratory failure...
  11. FUNCTION AND CONTROL OF THE LARYNX IN THE NEONATE
    Alastair Hutchison; Fiscal Year: 1991
    ..Since anesthesia and the presence of a tracheostomy can profoundly affect laryngeal muscle function, we shall study the lambs unanesthetized, with intact airways...
  12. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..of cardiac function in mice, investigators were limited to invasive measurements requiring heavy anesthesia, tracheostomy, and catheterization...
  13. Pulmonary Airflow Monitor in Tracheostomized Children
    MALVERN BENJAMIN; Fiscal Year: 2007
    ..life threatening emergencies, highly complex surgery, and acute respiratory failure and subsequently require a tracheostomy for months or sometimes years...
  14. Molecular genetics of familial laryngeal paralysis
    Jose Manaligod; Fiscal Year: 2006
    Laryngeal paralysis is a frequent cause of stridor and airway obstruction in infants, often requiring tracheostomy or other surgical procedures to provide an adequate airway...
  15. DETERMINANTS OF CARDIAC ABNORMALITIES IN ALCOHOLICS
    Timothy Regan; Fiscal Year: 1980
    ..In view of the fact that long-term tracheostomy preparations in the large mongrel dog are not feasible and since chronic nicotine administration qualitatively ..
  16. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2008
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  17. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2003
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  18. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2004
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  19. PHARMACOGENETICS IN SURGICAL CRITICAL CARE
    Bradley Freeman; Fiscal Year: 2004
    ..The environment for this project is Washington University School of Medicine, an institution with access to a large clinical volume and established expertise in genomic research. ..
  20. Outcomes of Prolonged Mechanical Ventilation
    Shannon Carson; Fiscal Year: 2006
    ..In addition, these data will inform future cohort studies and randomized controlled trials designed to improve outcomes for this growing patient population. ..
  21. Metabolomic Signatures in ALS
    Merit Cudkowicz; Fiscal Year: 2005
    ..abstract_text> ..
  22. Speech Intelligibility Testing in Children with Repaired Cleft Palate
    David Zajac; Fiscal Year: 2007
    ..abstract_text> ..
  23. cGMP Compartmentalization in Pulmonary Endothelial Barrier Dysfunction
    Eric Schmidt; Fiscal Year: 2008
    ..Understanding how cGMP worsens endothelial leakiness could lead to better therapies of acute lung injury. [unreadable] [unreadable] [unreadable] [unreadable]..
  24. DOUBLE BLIND STUDY OF MINOCYCLINE IN HD
    Merit Cudkowicz; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  25. Dose Study of thymus Transplantation
    MARY MARKERT; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  26. Critical Role of Alveolar Fibrin in Acute Lung Injury
    Gilman Allen; Fiscal Year: 2008
    ..abstract_text> ..
  27. CLINICAL TRIAL OF TOPIRAMATE IN ALS
    Merit Cudkowicz; Fiscal Year: 2003
    ..Secondary outcome measures include grip strength, forced vital capacity, the ALS functional rating scale, and the safety and tolerability of topiramate in this population. ..
  28. Phase I Serum-free cultured thymus transplantation in DiGeorge anomaly, IND9836,
    MARY MARKERT; Fiscal Year: 2009
    ..The focus of these experiments is the development of thymopoiesis and normal presentation of promiscuously expressed antigens in the thymus. ..
  29. Symptom Management, Patient-Caregiver Communication, and Outcomes in ICU
    MARY HAPP; Fiscal Year: 2009
    ....
  30. Gene Polymorphisms, Inflammation and Outcome from Trauma
    GRANT O KEEFE; Fiscal Year: 2007
    ..This information will allow clinicians and researchers to more rationally investigate and use specific therapies aimed at reducing the devastating consequences of severe injury and infection. ..
  31. Respiratory activities of intrinsic tongue muscles
    E Bailey; Fiscal Year: 2004
    ....
  32. SPEECH AND RESPIRATORY AERODYNAMICS IN CLEFT PALATE
    David Zajac; Fiscal Year: 2003
    ..It is possible, for example, that therapeutic techniques may be developed that incorporate specific respiratory strategies employed by speakers with cleft palate who exhibit acceptable speech characteristics. ..
  33. Ventilator Weaning:Processes of Care and Communication
    MARY HAPP; Fiscal Year: 2003
    ....
  34. Early Assessment of Infants with Cleft Palate Following Surgical Repair
    David Zajac; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Clinical Trial of Ceftriaxone in ALS
    Merit Cudkowicz; Fiscal Year: 2004
    ..The primary outcome measure for the STAGE III study will be time to death, tracheostomy or permanent assisted ventilation...
  36. Coenzyme Q10 in Huntington's Disease
    Merit Cudkowicz; Fiscal Year: 2007
    ..abstract_text> ..
  37. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  38. Cardiovascular Disease (C/V) in Children with Obstructive Sleep Apnea (OSA)
    Raouf Amin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  39. Parathyroid and Thymus Transplants in DiGeorge Syndrome
    MARY MARKERT; Fiscal Year: 2005
    ..Indirect allorecognition as a mechanism of graft rejection will be assessed by ELISpot. The third aim will assess safety and tolerability. ..
  40. Chronic Lung Allograft Rejection in MHC-Defined Swine
    James Allan; Fiscal Year: 2005
    ..abstract_text> ..
  41. Dynamics of TCR Repertoire Following Thymus Transplant
    MARY MARKERT; Fiscal Year: 2008
    ..These findings will have application to thymus and bone marrow transplantation for immunodeficiency and cancer. ..
  42. COPD Clinical Research Network & Clinical Research Skills Core Development
    Gerard Criner; Fiscal Year: 2007
    ..abstract_text> ..
  43. MMP-9-Dependent Vessel Wall Remodeling is NO-Dependent
    Gilbert Upchurch; Fiscal Year: 2005
    ....
  44. Identification and characterization of the DFNB17 gene
    John Greinwald; Fiscal Year: 2006
    ....
  45. COGNITIVE AND PHYSICAL BASIS OF DISABLEMENT
    Steven Albert; Fiscal Year: 2005
    ..g., mild disabled) than others. This finding would suggest that disability may be reduced through remediation of motor and cognitive/process skills, as well as by efforts to reduce impairment. ..
  46. Vascular Functions in Children with Sleep Disorder Breathing
    Raouf S Amin; Fiscal Year: 2010
    ....
  47. Effect of leukoreduction on infection risk in trauma
    Avery Nathens; Fiscal Year: 2004
    ..abstract_text> ..
  48. Improving Communication with NonSpeaking ICU Patients
    MARY HAPP; Fiscal Year: 2007
    ..Statistical analysis will involve hierarchical generalized linear modeling (HGLM) by outcome groups and planned group comparisons using linear contrasts within the context of the HGLM. ..
  49. IGF-I/ALS Trial
    Eric Sorenson; Fiscal Year: 2007
    ..Secondary endpoints will be tracheostomy free survival and change in ALSFRS score over the 2 year study period...
  50. DEPRESSION AND DISABILITY IN PATIENTS WITH HEART FAILURE
    Carolyn Turvey; Fiscal Year: 2004
    ..Her long-term career goal is to develop interventions that promote healthy aging amongst elders faced with functional decline. ..
  51. Bcl-2 and Ca2+ Homeostasis in Cardiac Dysfunction
    Ulrich Schmidt; Fiscal Year: 2006
    ..The ability to modify apoptosis and contractile properties in heart failure would represent an important step towards developing new therapeutic approaches for heart failure. ..
  52. QUANTITATIVE FUNCTION IN MOTOR NEURON DISEASE
    Eric Sorenson; Fiscal Year: 2004
    ..This will become increasingly important as our population ages, increasing demands for medical and social resources. ..
  53. DEPRESSION AND END OF LIFE CARE IN ALS
    Steven Albert; Fiscal Year: 2003
    ..In the final 6-9 months of life, patients must choose (either explicitly or by default) palliation or tracheostomy and long-term mechanical ventilation (LTMV)...
  54. Interpersonal Psychotherapy for Depression in Heart Failure
    Carolyn Turvey; Fiscal Year: 2008
    ..Although the focus of the treatment study is patients with heart failure, the long-term goal is to develop a treatment that reduces depression in elders suffering from irreversible loss in function. [unreadable] [unreadable] [unreadable]..