colposcopy

Summary

Summary: The examination, therapy or surgery of the cervix and vagina by means of a specially designed endoscope introduced vaginally.

Top Publications

  1. ncbi Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study
    Philip E Castle
    American Society for Clinical Pathology Institute, Washington, DC 20005, USA
    Lancet Oncol 12:880-90. 2011
  2. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007
  3. pmc Human papillomavirus testing in the prevention of cervical cancer
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 103:368-83. 2011
  4. ncbi Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3033-42. 2008
  5. pmc Performance of p16/Ki-67 immunostaining to detect cervical cancer precursors in a colposcopy referral population
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Clin Cancer Res 18:4154-62. 2012
  6. ncbi European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1
    J Jordan
    Birmingham Women s Hospital, Birmingham, UK
    Cytopathology 19:342-54. 2008
  7. ncbi Accuracy of visual inspection with acetic acid for cervical cancer screening
    Catherine Sauvaget
    Early Detection and Prevention Section, Screening Group, International Agency for Research on Cancer, Lyon, France
    Int J Gynaecol Obstet 113:14-24. 2011
  8. pmc American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer
    Debbie Saslow
    Breast and Gynecologic Cancer, Cancer Control Science Department, American Cancer Society, Atlanta, GA 30303, USA
    J Low Genit Tract Dis 16:175-204. 2012
  9. ncbi Significance of HPV 16 and 18 viral load quantitation in women referred for colposcopy
    Xavier Carcopino
    Department of Obstetrics and Gynecology, Assistance Publique des Hopitaux de Marseille, Hopital Nord, Marseille, France
    J Med Virol 84:306-13. 2012
  10. ncbi Accuracy of colposcopy-directed punch biopsies: a systematic review and meta-analysis
    M Underwood
    Department of Gynaecological Oncology, University Hospital of North Staffordshire, Stoke on Trent, UK
    BJOG 119:1293-301. 2012

Detail Information

Publications312 found, 100 shown here

  1. ncbi Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study
    Philip E Castle
    American Society for Clinical Pathology Institute, Washington, DC 20005, USA
    Lancet Oncol 12:880-90. 2011
    ..We did a subanalysis of this population to compare the screening performance of the cobas HPV test versus liquid-based cytology in women aged 25 years and older, and assess management strategies for HPV-positive women...
  2. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007
    ....
  3. pmc Human papillomavirus testing in the prevention of cervical cancer
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 103:368-83. 2011
    ..The greatest potential for reduction in cervical cancer rates from HPV screening is in low-resource regions that can implement infrequent rounds of low-cost HPV testing and treatment...
  4. ncbi Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3033-42. 2008
    ..This study compared the sensitivity and specificity of several adjunctive tests for the detection of high-grade CIN in a population referred to colposcopy because of abnormal cytology.
  5. pmc Performance of p16/Ki-67 immunostaining to detect cervical cancer precursors in a colposcopy referral population
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Clin Cancer Res 18:4154-62. 2012
    ..However, the specificity of HPV DNA testing is limited, requiring additional, more disease-specific markers for efficient screening approaches...
  6. ncbi European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1
    J Jordan
    Birmingham Women s Hospital, Birmingham, UK
    Cytopathology 19:342-54. 2008
    ..or with an equivocal cytology result and a positive human papillomavirus (HPV) test should be referred for colposcopy. The role of the colposcopist is to identify the source of the abnormal cells and to make an informed decision ..
  7. ncbi Accuracy of visual inspection with acetic acid for cervical cancer screening
    Catherine Sauvaget
    Early Detection and Prevention Section, Screening Group, International Agency for Research on Cancer, Lyon, France
    Int J Gynaecol Obstet 113:14-24. 2011
    ..To provide an updated estimation of the accuracy of visual inspection with acetic acid (VIA) in detecting true disease...
  8. pmc American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer
    Debbie Saslow
    Breast and Gynecologic Cancer, Cancer Control Science Department, American Cancer Society, Atlanta, GA 30303, USA
    J Low Genit Tract Dis 16:175-204. 2012
    ..contributions from six working groups, and a recent symposium co-sponsored by the ACS, American Society for Colposcopy and Cervical Pathology (ASCCP), and American Society for Clinical Pathology (ASCP), which was attended by 25 ..
  9. ncbi Significance of HPV 16 and 18 viral load quantitation in women referred for colposcopy
    Xavier Carcopino
    Department of Obstetrics and Gynecology, Assistance Publique des Hopitaux de Marseille, Hopital Nord, Marseille, France
    J Med Virol 84:306-13. 2012
    ..for optimal prediction of grade 2 or higher cervical intraepithelial neoplasia among patients referred to colposcopy. A total of 186 cervico-vaginal specimens harboring HPV 16 and/or 18 obtained at the time of colposcopy from ..
  10. ncbi Accuracy of colposcopy-directed punch biopsies: a systematic review and meta-analysis
    M Underwood
    Department of Gynaecological Oncology, University Hospital of North Staffordshire, Stoke on Trent, UK
    BJOG 119:1293-301. 2012
    The colposcopy-directed punch biopsy is widely used in the management of women with abnormal cervical cytology; however, its accuracy compared with definitive histology from an excision biopsy is not well established.
  11. ncbi Accuracy of visual screening for cervical neoplasia: Results from an IARC multicentre study in India and Africa
    Rengaswamy Sankaranarayanan
    Unit of Descriptive Epidemiology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 110:907-13. 2004
    ..A common protocol and questionnaire was used. For final diagnosis, all women were investigated with colposcopy and biopsies were taken when necessary...
  12. ncbi Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer
    Marie Helene Mayrand
    Department of Oncology and Epidemiology and Biostatistics, McGill University, Montreal, Canada
    N Engl J Med 357:1579-88. 2007
    ..To determine whether testing for DNA of oncogenic human papillomaviruses (HPV) is superior to the Papanicolaou (Pap) test for cervical-cancer screening, we conducted a randomized trial comparing the two methods...
  13. ncbi Colposcopically directed biopsy, random cervical biopsy, and endocervical curettage in the diagnosis of cervical intraepithelial neoplasia II or worse
    Robert G Pretorius
    Department of Obstetrics and Gynecology, Southern California Permanente Medical Group, Fontana, CA, USA
    Am J Obstet Gynecol 191:430-4. 2004
    ..Study design During a screening study, 364 women with satisfactory colposcopy and > or =CIN II were diagnosed. All colposcopically detected lesions were biopsied...
  14. ncbi The psychological impact of abnormal cytology and colposcopy
    K E Rogstad
    Department of Genitourinary Medicine, Royal Hallamshire Hospital, Sheffield, UK
    BJOG 109:364-8. 2002
  15. ncbi Adolescent sexual assault: documentation of acute injuries using photo-colposcopy
    J A Adams
    University of California, San Diego Medical Center, San Diego, CA 92103 8449, USA
    J Pediatr Adolesc Gynecol 14:175-80. 2001
    ..To document the frequency and types of genital injuries in adolescent women examined acutely following a sexual assault, and determine any historical correlates of injury...
  16. ncbi A novel optical imaging method for the early detection, quantitative grading, and mapping of cancerous and precancerous lesions of cervix
    C Balas
    FO R T H Institute of Electronic Structure and LASER, P O Box 1527, 71110 Heraklion Crete Greece
    IEEE Trans Biomed Eng 48:96-104. 2001
    ..The demonstrated improved sensitivity and specificity highlight the potential of the method in both clinical research and noninvasive diagnosis...
  17. ncbi Long term review of laparoscopic sacrocolpopexy
    P J Higgs
    Urogynaecology Department, Royal Women s Hospital, Melbourne, Australia
    BJOG 112:1134-8. 2005
    ..Assessment of long term outcome following laparoscopic sacrocolpopexy...
  18. ncbi Effective cervical neoplasia detection with a novel optical detection system: a randomized trial
    Ronald D Alvarez
    University of Alabama at Birmingham, Birmingham, AL, USA
    Gynecol Oncol 104:281-9. 2007
    To assess whether the use of a novel optical detection system (ODS) as an adjunct to colposcopy increases the detection of biopsy-confirmed CIN 2,3.
  19. pmc Comparison of visual inspection with acetic acid and cervical cytology to detect high-grade cervical neoplasia among HIV-infected women in India
    Vikrant V Sahasrabuddhe
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Cancer 130:234-40. 2012
    ..India, by simultaneous and independent screening with VIA and cervical cytology with disease ascertainment by colposcopy and histopathology...
  20. ncbi A prospective Swedish cohort study on psychosocial factors influencing anxiety in women referred for colposcopy
    C Hellsten
    Department of Obstetrics and Gynaecology, Malmo University Hospital, Lund University, Malmo, Sweden
    BJOG 114:32-8. 2007
    To elucidate risk factors for high state anxiety in women referred for colposcopy.
  21. ncbi Liquid compared with conventional cervical cytology: a systematic review and meta-analysis
    Marc Arbyn
    Scientific Institute of Public Health, Brussels, Belgium
    Obstet Gynecol 111:167-77. 2008
    ..To compare test performance characteristics of conventional Pap tests and liquid-based cervical cytology samples...
  22. ncbi Direct comparison of liquid-based and conventional cytology in a South African screening trial
    Sylvia Taylor
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Int J Cancer 118:957-62. 2006
    ..Directly following collection of the cytology specimen, all women underwent colposcopy with endocervical curettage and biopsy of all colposcopic abnormalities...
  23. ncbi HPV screening for cervical cancer in rural India
    Rengaswamy Sankaranarayanan
    International Agency for Research on Cancer, Lyon, France
    N Engl J Med 360:1385-94. 2009
    ....
  24. ncbi Screening and adenocarcinoma of the cervix
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London, United Kingdom
    Int J Cancer 125:525-9. 2009
    ..The impact of screening on adenosquamous carcinoma is similar to its impact on squamous carcinoma...
  25. ncbi Use of p16-INK4A overexpression to increase the specificity of human papillomavirus testing: a nested substudy of the NTCC randomised controlled trial
    Francesca Carozzi
    Centre for Cancer Study and Prevention, Florence, Italy
    Lancet Oncol 9:937-45. 2008
    ..We assessed whether HPV testing with triage by p16-INK4A overexpression can increase specificity while maintaining sensitivity...
  26. ncbi Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results
    M M Manos
    Division of Research, Northern California Kaiser Permanente Medical Group, Oakland 94611, USA
    JAMA 281:1605-10. 1999
    ..Only 5% to 10% of women with ASCUS harbor serious cervical disease, but more than one third of the high-grade squamous intraepithelial lesions (HSILs) in screening populations are identified from ASCUS Pap test results...
  27. ncbi HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancer
    T C Wright
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    JAMA 283:81-6. 2000
    ..In many other regions of the world, there is only limited access to cervical cancer screening...
  28. ncbi The Swede score: evaluation of a scoring system designed to improve the predictive value of colposcopy
    Julie Bowring
    Academic Department of Obstetrics and Gynaecology, Colposcopy Unit, Royal Free Hospital, London, UK
    J Low Genit Tract Dis 14:301-5. 2010
    It has been suggested that the accuracy of colposcopy is less reliable than once presumed...
  29. ncbi More questions about the accuracy of colposcopy: what does this mean for cervical cancer prevention?
    J Thomas Cox
    Obstet Gynecol 111:1266-7. 2008
  30. ncbi Detection of human papillomavirus genotypes among high-risk women: a comparison of hybrid capture and linear array tests
    Joseph Monsonego
    Institut Alfred Fournier Paris, France
    Sex Transm Dis 35:521-7. 2008
    ..To assess the concordance and performance of 2 different assays in detection of human papillomavirus (HPV) genotypes among women with abnormal Pap smear...
  31. ncbi The use of electrical impedance spectroscopy in the detection of cervical intraepithelial neoplasia
    S Abdul
    Sheffield Gynaecological Cancer Centre, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Int J Gynecol Cancer 16:1823-32. 2006
    ..A prospective observational study recruited women referred to colposcopy with an abnormal Papanicolaou smear...
  32. pmc Inclusion of HPV testing in routine cervical cancer screening for women above 29 years in Germany: results for 8466 patients
    K U Petry
    Abteilung für gynäkologische Onkologie MHH, Hannover, Germany
    Br J Cancer 88:1570-7. 2003
    In a prospective cohort study 8466 women attending routine cervical cancer screening were recruited. Colposcopy was performed on women with any degree of atypia on cytology and/or a positive high-risk human papillomavirus (HPV)-DNA test (..
  33. ncbi Stepwise algorithm combining HPV high-risk DNA-based assays and RNA-based assay for high grade CIN in women with abnormal smears referred to colposcopy
    Philippe Halfon
    Hopital Ambroise Pare, Marseille, France
    Cancer Biomark 7:133-9. 2010
    ..The detection of high-risk human papillomavirus (HPV) DNA provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN)...
  34. ncbi The performance of a new scoring system for colposcopy in detecting high-grade dysplasia in the uterine cervix
    Bjorn Strander
    Department of Obstetrics and Gynecology, The Sahlgrenska Academy, University of Goteborg, Goteborg, Sweden
    Acta Obstet Gynecol Scand 84:1013-7. 2005
    ..To construct a simple scoring system for colposcopic examination that can facilitate education of colposcopists and increase the accuracy of evaluation...
  35. ncbi Who defaults from colposcopy? A multi-centre, population-based, prospective cohort study of predictors of non-attendance for follow-up among women with low-grade abnormal cervical cytology
    Linda Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Eur J Obstet Gynecol Reprod Biol 165:318-25. 2012
    The success of cervical screening relies on women with abnormal cervical cytology attending for follow-up by colposcopy and related procedures. Failure to attend for colposcopy, however, is a common problem in many countries...
  36. ncbi 2011 colposcopic terminology of the International Federation for Cervical Pathology and Colposcopy
    Jacob Bornstein
    Nomenclature Committee of the International Federation for Cervical Pathology and Colposcopy, Department of Obstetrics and Gynecology, Western Galilee Hospital, and the Bar Ilan University Faculty of Medicine, Nahariya, Israel
    Obstet Gynecol 120:166-72. 2012
    New colposcopy terminology was prepared by the Nomenclature Committee of the International Federation of Cervical Pathology and Colposcopy after a critical review of previous terminologies, online discussions, and discussion with national ..
  37. pmc Risk of preterm birth after treatment for cervical intraepithelial neoplasia among women attending colposcopy in England: retrospective-prospective cohort study
    Alejandra Castanon
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London EC1M 6BQ, UK
    BMJ 345:e5174. 2012
    To explore the association between preterm delivery and treatment at colposcopy.
  38. ncbi The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology
    Teresa M Darragh
    Departments of Pathology and Obstetrics, Gynecology and Reproductive Science, University of California San Francisco Mt Zion Medical Center, 1600 Divisadero St, San Francisco, CA 94115, USA
    J Low Genit Tract Dis 16:205-42. 2012
    ..Terminology (LAST) Project was cosponsored by the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology and included 5 working groups; 3 work groups performed comprehensive literature reviews ..
  39. ncbi The up-to-date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia: the Cochrane colposcopy & cervical cytopathology collaborative group (C5 group) approach
    M Kyrgiou
    Department of Obstetrics and Gynaecology, Hammersmith Hospital, Queen Charlotte s and Chelsea Hospital, London W12 0HS, UK
    Cancer Treat Rev 32:516-23. 2006
    This overview presents the up-to-date evidence on colposcopy practice and other diagnostic modalities such as HPV DNA test and cytology for cervical intraepithelial neoplasia (CIN)...
  40. ncbi Subsequent risk and presentation of cervical intraepithelial neoplasia (CIN) 3 or cancer after a colposcopic diagnosis of CIN 1 or less
    Robert G Pretorius
    Department of Obstetrics and Gynecology, Southern California Permanente Medical Group, Fontana, CA 92335, USA
    Am J Obstet Gynecol 195:1260-5. 2006
    ..The purpose of this study was to determine the risk and presentation of cervical intraepithelial neoplasia (CIN) 3 or cancer after colposcopic diagnosis of CIN 1 or less...
  41. ncbi The Lower Anogenital Squamous Terminology Standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology
    Teresa M Darragh
    University of California, San Francisco, CA, USA
    Int J Gynecol Pathol 32:76-115. 2013
    ..LAST) project was co-sponsored by the College of American Pathologists (CAP) and the American Society for Colposcopy and Cervical Pathology (ASCCP) and included 5 working groups; three work groups performed comprehensive ..
  42. ncbi Have we dismissed ablative treatment too soon in colposcopy practice?
    E Paraskevaidis
    Department of Obstetrics and Gynaecology, University Hospital of Ioannina, Ioannina, Greece
    BJOG 114:3-4. 2007
  43. pmc Age-group differences in human papillomavirus types and cofactors for cervical intraepithelial neoplasia 3 among women referred to colposcopy
    Julia W Gargano
    Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, MS C09, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
    Cancer Epidemiol Biomarkers Prev 21:111-21. 2012
    ..Here, we assess age-group differences in HPV types and other risk factors for cervical intraepithelial neoplasia (CIN) grade 3 or worse (CIN3+) versus CIN0-2 in women from four colposcopy clinics.
  44. ncbi Regression of low-grade squamous intra-epithelial lesions in young women
    Anna Barbara Moscicki
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Lancet 364:1678-83. 2004
    ..The aim of this study was to assess the probability of low-grade squamous intra-epithelial lesion (LSIL) regression in young women, and to examine the factors associated with this regression...
  45. ncbi Loop excision for high-grade squamous intraepithelial lesion on cytology: correlation with colposcopic and histologic findings
    Dennis C Szurkus
    Division of Gynecologic Oncology, Naval Medical Center, PSC 1003 Box 8, San Diego FPO AE, CA 09728, USA
    Am J Obstet Gynecol 188:1180-2. 2003
    ....
  46. ncbi Chlamydia trachomatis, herpes simplex virus 2, and human T-cell lymphotrophic virus type 1 are not associated with grade of cervical neoplasia in Jamaican colposcopy patients
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Sex Transm Dis 30:575-80. 2003
    ..A few recent studies have suggested that other sexually transmitted infections may increase the likelihood of a human papillomavirus (HPV) infection progressing to high-grade cervical neoplasia and cancer...
  47. ncbi Role of P16(INK4a) expression in identifying CIN2 or more severe lesions among HPV-positive patients referred for colposcopy after abnormal cytology
    Francesca Carozzi
    Center for the Study and Prevention of Cancer, Florence, Italy
    Cancer 108:119-23. 2006
    ....
  48. ncbi Prevalence of type-specific human papillomavirus in endocervical, upper and lower vaginal, perineal and vaginal self-collected specimens: Implications for vaginal self-collection
    Jerome L Belinson
    Department of Gynecology, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Int J Cancer 127:1151-7. 2010
    ..The principal cause of the lower specificity of self-collected specimens is HR-HPV present solely in the vagina, which is not associated with > or = CIN 2...
  49. ncbi Laparoscopic sacrocolpopexy for the correction of vaginal vault prolapse
    Chandru P Sundaram
    Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Endourol 18:620-3; discussion 623-4. 2004
    ..Laparoscopic sacrocolpopexy offers a minimally invasive approach to correcting vaginal vault prolapse. We describe our operative technique and review our experience...
  50. ncbi Interobserver agreement for colposcopy quality control using digitized colposcopic images during the ALTS trial
    Daron G Ferris
    Gynecologic Cancer Prevention Center, Department of Family Medicine, The Medical College of Georgia, Augusta, GA 30912, USA
    J Low Genit Tract Dis 9:29-35. 2005
    To estimate interobserver agreement among colposcopy quality control reviewers viewing digitized cervical images during the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS).
  51. ncbi A randomised comparison of SurePath liquid-based cytology and conventional smear cytology in a colposcopy clinic setting
    P H Sykes
    Department of Obstetrics and Gynaecology, University of Otago, Christchurch, New Zealand
    BJOG 115:1375-81. 2008
    ..The objective of this study was to compare the sensitivity of cervical cytology using conventional smears and SurePath liquid-based cytology (LBC)...
  52. ncbi Regardless of skill, performing more biopsies increases the sensitivity of colposcopy
    Robert G Pretorius
    Department of Obstetrics and Gynecology, Southern California Permanente Medical Group Fontana, Fontana, CA, USA
    J Low Genit Tract Dis 15:180-8. 2011
    ..cervical intraepithelial neoplasia [CIN], or cancer) for CIN 3 or cancer (CIN 3+) among physicians and to estimate the increase in yield of CIN 3+ per colposcopy associated with "random" biopsies and/or endocervical curettage (ECC).
  53. pmc Detection of cervical infections in colposcopy clinic patients
    S Lanham
    Department of Molecular Microbiology, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Clin Microbiol 39:2946-50. 2001
    ..The presence of human herpesvirus 7 may increase the oncogenic potential of moderate-risk human papillomavirus types...
  54. doi Heterogeneity in CIN3 diagnosis
    Mark Schiffman
    Lancet Oncol 9:404-6. 2008
  55. ncbi Visual inspection for cervical cancer screening: evaluation by doctor versus paramedical worker
    N Bhatla
    Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi 110 029, India
    Indian J Cancer 41:32-6. 2004
    ..In the absence of an effective cervical cancer screening programme, efforts are being made to explore the feasibility of using the existing infrastructure to develop effective low-cost screening methods...
  56. ncbi Digital tools for collecting data from cervigrams for research and training in colposcopy
    Jose Jeronimo
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute, Bethesda, MD 20892, USA
    J Low Genit Tract Dis 10:16-25. 2006
    b>Colposcopy is a critical part of gynecologic practice but has documented deficiencies, including lack of correlation between the colposcopic appearance and the severity of underlying neoplasia, limited reproducibility, and difficulty in ..
  57. ncbi Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study
    Margaret R E McCredie
    Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
    Lancet Oncol 9:425-34. 2008
    ..We aimed to estimate the long-term risk of invasive cancer in these two groups of women. A judicial inquiry referred for independent clinical review in 1988 all women for whom there remained doubt about the adequacy of their management...
  58. ncbi Randomized healthservices study of human papillomavirus-based management of low-grade cytological abnormalities
    Lena Dillner
    Department of Clinical Microbiology, WHO HPVLabNet Global Reference laboratory, Lund University, Malmo University Hospital, SE 20502 Malmo, Sweden
    Int J Cancer 129:151-9. 2011
    ..screening program in Stockholm, Sweden screening program were randomized to either continue with prior policy (colposcopy of all women with ASCUS/CINI) or to implement a policy with HPV triaging and colposcopy only of HPV-positive ..
  59. ncbi A randomized trial of basing treatment on human papillomavirus and/or cytology results in low-grade cervical lesion triage
    Pontus Bjerre
    Department of Obstetrics and Gynecology, Central Hospital, Karlstad, Sweden
    Am J Obstet Gynecol 199:24.e1-7. 2008
    ..This study was undertaken to compare management algorithms that base treatment with loop electrosurgical excision procedure on human papillomavirus and/or repeat Papanicolaou test smear results...
  60. ncbi A 2-year follow-up study of anxiety and depression in women referred for colposcopy after an abnormal cervical smear
    C Hellsten
    Department of Obstetrics and Gynaecology, Malmo University Hospital, Lund University, Malmo, Sweden
    BJOG 115:212-8. 2008
    The aim of this study was to determine if there were any long-lasting elevated anxiety levels in women attending colposcopy after an abnormal cervical smear.
  61. ncbi Underlying pathology of women with "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" smears, in a region with a high incidence of cervical cancer
    Chumnan Kietpeerakool
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    J Obstet Gynaecol Res 34:204-9. 2008
    ..To evaluate the histopathology of women who had "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions" (ASC-H) on cervical cytology in a region with high incidence of cervical cancer...
  62. ncbi Human papillomavirus testing in women with mild cytologic atypia
    C Bergeron
    Laboratoire Pasteur Cerba, Cergy Pontoise, France
    Obstet Gynecol 95:821-7. 2000
    ....
  63. pmc Can human papillomavirus DNA testing of self-collected vaginal samples compare with physician-collected cervical samples and cytology for cervical cancer screening in developing countries?
    Neerja Bhatla
    Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Cancer Epidemiol 33:446-50. 2009
    ....
  64. pmc Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:113-20. 2009
    ..Investigations on the molecular distinctions along the disease continuum of cervical pathogenesis by HPV type are needed...
  65. pmc The accuracy of colposcopic grading for detection of high-grade cervical intraepithelial neoplasia
    L Stewart Massad
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Low Genit Tract Dis 13:137-44. 2009
    ..To relate aspects of online colposcopic image assessment to the diagnosis of grades 2 and 3 cervical intraepithelial neoplasia (CIN 2+)...
  66. ncbi Diagnostic accuracy of guided cervical biopsies: a prospective multicenter study comparing the histopathology of simultaneous biopsy and cone specimen
    Christian Zuchna
    Department of Obstetrics and Gynecology, Paracelsus Medical University, Salzburg, Austria
    Am J Obstet Gynecol 203:321.e1-6. 2010
    ..We sought to determine the validity of colposcopically directed cervical biopsies as a diagnostic test to define the degree of cervical intraepithelial neoplasia (CIN)...
  67. pmc The probability for a Pap test to be abnormal is directly proportional to HPV viral load: results from a Swiss study comparing HPV testing and liquid-based cytology to detect cervical cancer precursors in 13,842 women
    G Bigras
    Laboratoire Cytopath, Unilabs SA, 12 Place Cornavin, Genève 1, CH 1211, Switzerland
    Br J Cancer 93:575-81. 2005
    ..A total of 1334 women were found to be positive for one or both tests and were invited for colposcopy with biopsy...
  68. ncbi Direct visual inspection for cervical cancer screening: an analysis of factors influencing test performance
    Lynette Denny
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Cancer 94:1699-707. 2002
    ..The authors evaluated direct visual inspection of the cervix after the application of 5% acetic acid (DVI) as a cervical cancer screening test for use in low-resource settings...
  69. ncbi Visual inspection as a cervical cancer screening method in a primary health care setting in Africa
    Ghislain Sangwa-Lugoma
    Department of Obstetrics and Gynecology, University of Kinshasa, Kinshasa, Democratic Republic of Congo
    Int J Cancer 119:1389-95. 2006
    ..samples were obtained from women with abnormal colposcopies and from 290 randomly chosen women with normal colposcopy. Cytological and histological examinations were performed in Lyon and Montreal, respectively...
  70. ncbi A long-term study of women with normal colposcopy after referral with low-grade cytological abnormalities
    M C G Smith
    Department of Gynaecological Oncology, Hammersmith Hospital, London, UK
    BJOG 113:1321-8. 2006
    About 50,000 women are referred annually to colposcopy in England because of a low-grade smear...
  71. ncbi Efficacy of human papillomavirus-based screen-and-treat for cervical cancer prevention among HIV-infected women
    Louise Kuhn
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    AIDS 24:2553-61. 2010
    ..Here, we evaluate the efficacy among HIV-infected women of a simpler, screen-and-treat strategy in which all women with a positive screening test are treated with cryotherapy...
  72. pmc Prevalence and predictors of colposcopic-histopathologically confirmed cervical intraepithelial neoplasia in HIV-infected women in India
    Vikrant V Sahasrabuddhe
    Institute for Global Health, Vanderbilt University, Nashville, Tennessee, USA
    PLoS ONE 5:e8634. 2010
    ..We sought to better establish prevalence estimates and evaluate risk factors of CIN among HIV-infected women in Pune, India using colposcopy and histopathology as diagnostic tools.
  73. ncbi Human papillomavirus DNA testing for the detection of cervical intraepithelial neoplasia grade 3 and cancer: 5-year follow-up of a randomised controlled implementation trial
    N W J Bulkmans
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet 370:1764-72. 2007
    ..Our aim was to determine whether the effectiveness of cervical screening improves when HPV DNA testing is implemented...
  74. ncbi Vaginal mesh erosion after abdominal sacral colpopexy
    A G Visco
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA
    Am J Obstet Gynecol 184:297-302. 2001
    ..Our goal was to compare the prevalence of vaginal mesh erosion between abdominal sacral colpopexy and various sacral colpoperineopexy procedures...
  75. ncbi High-risk human papillomavirus DNA test and p16(INK4a) in the triage of LSIL: a prospective diagnostic study
    I Tsoumpou
    Department of Obstetrics and Gynecology, University Hospitals of South Manchester, Manchester, UK
    Gynecol Oncol 121:49-53. 2011
    ....
  76. ncbi Accuracy of visual inspection with acetic acid (VIA) for cervical cancer screening: a systematic review
    Paskorn Sritipsukho
    Postgraduate Studies Program, Faculty ofMedicine, Thammasat University, Pathumthani, Thailand
    J Med Assoc Thai 93:S254-61. 2010
    ..To systematically review the performance characteristics of VIA in cervical cancer screening...
  77. ncbi International terminology of colposcopy: an updated report from the International Federation for Cervical Pathology and Colposcopy
    P Walker
    Royal Free Hospital, London, United Kingdom
    Obstet Gynecol 101:175-7. 2003
  78. ncbi Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting
    Maarit Leinonen
    Mass Screening Registry, Finnish Cancer Registry, Pieni Roobertinkatu 9, FI 00130 Helsinki, Finland
    J Natl Cancer Inst 101:1612-23. 2009
    ..We compared the age-specific performance of primary HPV DNA screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in Finland...
  79. ncbi Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy
    J Thomas Cox
    University of California, Santa Barbara, USA
    Am J Obstet Gynecol 188:1406-12. 2003
    ..to determine the risk of cumulative cervical intraepithelial neoplasia (CIN) grade 2 or 3 according to initial colposcopy and directed biopsy results among women with low-grade squamous intraepithelial lesions (LSIL) or human ..
  80. ncbi Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: a randomized clinical trial
    Cornelis J A Hogewoning
    Department of Gynaecology and Obstetrics, Albert Schweitzer Hospital, Dordrecht, The Netherlands
    Int J Cancer 107:811-6. 2003
    ..They were conservatively managed and followed every 3-6 months by colposcopy, cytology and HPV testing by GP5+/6+ PCR. Baseline cervical biopsy specimens were taken...
  81. ncbi Evaluation of colposcopy vs cytology as secondary test to triage women found positive on visual inspection test
    S A Pimple
    Department of Preventive Oncology, Tata Memorial Hospital, Mumbai, India
    Indian J Cancer 47:308-13. 2010
    ..Colposcopic evaluation and guided biopsy is an important diagnostic step and standard of management for abnormal cytology smears in developed countries...
  82. ncbi Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive women
    Henry Kitchener
    Academic Unit of Obstetrics and Gynaecology, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Int J Cancer 121:2484-91. 2007
    ..women and determine the best management system by comparing cervical pathology according to results of cytology, colposcopy and human papillomavirus (HPV) testing at baseline and throughout follow-up. A...
  83. ncbi Papanicolaou and thin-layer cervical cytology with colposcopic biopsy control. A comparison
    C Blair Harkness
    Department of Obstetrics and Gynecology, Mountain Area Health Education Center, Pathologists Medical Laboratory, PA, Asheville, North Carolina, USA
    J Reprod Med 48:681-6. 2003
    ..To compare the accuracy of conventional Papanicolaou and fluid-based, thin-layer cervical cytology...
  84. ncbi Cervical cytology of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): characteristics and histologic outcomes
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Cancer 108:298-305. 2006
    ....
  85. ncbi A prospective evaluation of "see and treat" in women with HSIL Pap smear results: is this an appropriate strategy?
    T Michael Numnum
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294 7333, USA
    J Low Genit Tract Dis 9:2-6. 2005
    ..The objective of this study was to determine the incidence of CIN 2 and CIN 3 in patients with an HSIL (CIN 2) Pap smear using a see-and-treat protocol...
  86. ncbi The impact of the distribution of human papillomavirus types and associated high-risk lesions in a colposcopy population for monitoring vaccine efficacy
    Nick A Antonishyn
    Department of Chemistry and Biochemistry, University of Regina, Regina, Saskatchewan, Canada
    Arch Pathol Lab Med 132:54-60. 2008
    ..Vaccine cross protection for other important oncogenic HPV types and the emergence of potential genotype replacements require the knowledge of the prevaccine epidemiology of HPV...
  87. ncbi Atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): a result not to be ignored
    Drew Barreth
    Department of Obstetrics and Gynaecology, University of Alberta, Edmonton
    J Obstet Gynaecol Can 28:1095-8. 2006
    ....
  88. ncbi Safety, tolerability, and pharmacokinetics of SPL7013 gel (VivaGel): a dose ranging, phase I study
    John O'Loughlin
    Royal Adelaide Hospital, Adelaide, Australia
    Sex Transm Dis 37:100-4. 2010
    ..To evaluate safety, tolerability and systemic pharmacokinetics of escalating doses of SPL7013 Gel in healthy women...
  89. pmc Follow-up testing after colposcopy: five-year risk of CIN 2+ after a colposcopic diagnosis of CIN 1 or less
    Hormuzd A Katki
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, Bethesda, MD 20892, USA
    J Low Genit Tract Dis 17:S69-77. 2013
    Most women referred for colposcopy are not diagnosed with cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) but, nonetheless, are typically asked to return much sooner than their next routine screening interval in 3 to 5 years...
  90. ncbi Accuracy of physician and nurse practitioner colposcopy to effect improved surveillance of cervical cancer
    G Kilic
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX, USA
    Eur J Gynaecol Oncol 33:183-6. 2012
    To compare physician and nurse practitioner accuracy in recognizing cervical dysplasia during colposcopy.
  91. pmc Neither one-time negative screening tests nor negative colposcopy provides absolute reassurance against cervical cancer
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7234, USA
    Int J Cancer 125:1649-56. 2009
    ..Seven cancers represent failures of colposcopy to diagnose cancer or a precancerous lesion in screen-positive women...
  92. ncbi p16/Ki-67 dual staining in cervico-vaginal cytology: correlation with histology, Human Papillomavirus detection and genotyping in women undergoing colposcopy
    Maria Gabriella Donà
    STI Unit, San Gallicano Dermatological Institute, Via Elio Chianesi 53, 00144, Rome, Italy
    Gynecol Oncol 126:198-202. 2012
    ....
  93. ncbi Illumination, optics, and clinical performance of a hand-held magnified visual inspection device (AviScope): a comparison with colposcopy
    John W Sellors
    Program for Appropriate Technology in Health, Seattle, WA, USA
    J Acquir Immune Defic Syndr 37:S160-6. 2004
    b>Colposcopy is the reference standard for a visual inspection device in terms of illumination, optics, and clinical performance...
  94. ncbi Can visual inspection with acetic acid under magnification substitute colposcopy in detecting cervical intraepithelial neoplasia in low-resource settings?
    Pakhee Aggarwal
    Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Flat No 1119, Vasto, Mahagun Mansion, 1 4, Vaibhav Khand, Indirapuram, Ghaziabad 201014, Uttar Pradesh, India
    Arch Gynecol Obstet 284:397-403. 2011
    ..and negative predictive values and accuracy of visual inspection with acetic acid under magnification (VIAM) and colposcopy for detecting cervical intraepithelial neoplasia (CIN) to determine if VIAM can substitute colposcopy in ..
  95. ncbi Accuracy of colposcopy in the diagnostic setting compared with the screening setting
    Scott B Cantor
    Department of Biostatistics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Obstet Gynecol 111:7-14. 2008
    To estimate the accuracy of colposcopy to identify cervical precancer in screening and diagnostic settings.
  96. ncbi Should women with postcoital bleeding be referred for colposcopy?
    J Abu
    Department of Obstetrics and Gynaecology, University Hospital of Leicester, Leicester Royal Infirmary, Leicester, UK
    J Obstet Gynaecol 26:45-7. 2006
    ..was to determine the risk of finding significant cervical pathological abnormality in women referred to the colposcopy clinic primarily because of postcoital bleeding...
  97. ncbi Accuracy of colposcopy management to detect CIN3 and invasive cancer in women with abnormal screening tests: results from a primary HPV screening project from 2006 to 2011 in Wolfsburg, Germany
    Karl Ulrich Petry
    Department of Obstetrics and Gynecology, Klinikum Wolfsburg, Wolfsburg, Germany
    Gynecol Oncol 128:282-7. 2013
    ..We examined if this phenomenon may compromise the accuracy of colposcopy.
  98. ncbi A descriptive analysis of prevalent vs incident cervical intraepithelial neoplasia grade 3 following minor cytologic abnormalities
    Philip E Castle
    American Society for Clinical Pathology Institute, Washington, DC 20005, USA
    Am J Clin Pathol 138:241-6. 2012
    ..We concluded that most CIN 3 cases diagnosed within the 2-year time frame were prevalent cases, and most incident CIN 3 cases followed a prevalently detected HPV infection...
  99. ncbi Treatment of high-grade squamous intraepithelial lesions: a "see and treat" versus a three-step approach
    Oscar Sadan
    Cervical Clinic, Maccabi Health Services, Tel Aviv, Israel
    Eur J Obstet Gynecol Reprod Biol 131:73-5. 2007
    ....
  100. pmc Comparison of conventional cervical cytology versus visual inspection with acetic acid among human immunodeficiency virus-infected women in Western Kenya
    Hillary Mabeya
    United States Agency for International Development Academic Model Providing Access to Healthcare Partnership, Moi University School of Medicine, Eldoret, Kenya
    J Low Genit Tract Dis 16:92-7. 2012
    ..This study aimed to determine the accuracy of visual inspection with acetic acid (VIA) versus conventional Pap smear as a screening tool for cervical intraepithelial neoplasia/cancer among human immunodeficiency virus (HIV)-infected women...
  101. pmc Switch from cytology-based to human papillomavirus test-based cervical screening: implications for colposcopy
    Carolina Porras
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 130:1879-87. 2012
    ..is to evaluate the clinical implications of a switch to HPV test-based screening on performance and workload of colposcopy. Women in the population-based, 7-year Guanacaste cohort study were screened at enrollment using cytology...

Research Grants63

  1. Human papillomavirus as a risk factor for HIV infection
    PETER CHIN HONG; Fiscal Year: 2007
    ..Women will also undergo the same procedures as well as cervical PAP smears and colposcopy. To control for potential confounding, self reports regarding sexual behavior, drug use, STD history and ..
  2. Cervical Cancer Screening in HIV-infected women in India
    Sten Vermund; Fiscal Year: 2006
    ..of test performance of VIA and HPV-testing in comparison with conventional cytology to detect screen-positive or colposcopy-suggestive, histologically-confirmed HSIL among HIV+ women in Pune, India and 2...
  3. Human Papillomavirus Infection in Perinatally HIV-infected Adolescents in Asia
    Annette H Sohn; Fiscal Year: 2013
    ..monitor for cervical squamous intraepithelial lesions and intraepithelial neoplasia with cytology testing and colposcopy-directed cervical biopsy...
  4. Improving screening tools to better predict high-grade anal dysplasia for MSM
    Dorothy J Wiley; Fiscal Year: 2013
    ..to better predict high-grade cervical dysplasia in older females without atypias &to triage women to colposcopy with atypical squamous cells on cytology;they are not calibrated for IAC screening...
  5. Epigenetic changes predict disease course of HPV-related lesions in women 16-24
    NANCY B contact KIVIAT; Fiscal Year: 2010
    ..Aim 3: Follow enrolled women every 6 months (for up to 18 months) by colposcopy and collection of exfoliated cell samples for cytology and testing to determine whether changes in methylation ..
  6. Nano-architecture Based Biomarkers for Cervical Cancer Screening
    Yang Liu; Fiscal Year: 2013
    ..squamous cells of undetermined significance (ASC-US)", but HGCIN is confirmed on a subsequent follow-up colposcopy biopsy for only less than 5% of patients receiving this diagnosis...
  7. HPV Methylation as a Biomarker of Viral Persistence and Risk of Cervical Disease
    Michael D Wyatt; Fiscal Year: 2013
    ..The current false positive rate of pap test screening (~1 in 10 are "abnormal"), results in follow up colposcopy and biopsy that are financially and emotionally costly...
  8. Diagnosis of Cervical Precancers Using Raman Spectroscopy
    Anita Mahadevan-Jansen; Fiscal Year: 2012
    ..Existing screening and detection techniques, the Pap smear and colposcopy, have several deficiencies that prevent efficient management of an otherwise controllable disease...
  9. High-resolution optical imaging assessment of microbicide toxicity
    Massoud Motamedi; Fiscal Year: 2011
    ..Unfortunately, current imaging technology such as white light colposcopy or colonoscopy cannot provide high resolution images of epithelial injury and cannot probe below the surface ..
  10. High-throughput molecular-specific cell nanocytology for cancer screening
    Hariharan Subramanian; Fiscal Year: 2013
    ..women due to the introduction of the Pap- smear as an initial screening test that is followed by a more invasive colposcopy. However, no such two-tier screening paradigm is available for other cancers...
  11. Commercialization of the OncoE6TM Cervical Test for detection of HPV induced mali
    JOHANNES G SCHWEIZER; Fiscal Year: 2013
    ..cervical cancer prevalence has diminished by implementation of Pap testing (Cytology), followed by colposcopy and histology examination if the Pap test is positive...
  12. Molecular Methods to Improve Cervical Cancer Screening in HIV+ Women
    Howard D Strickler; Fiscal Year: 2013
    ..e., CIN-2+). Thus, most cervical colposcopy/biopsy are conducted unnecessarily at great expense to the health care system, as well as risk of bleeding, pain,..
  13. Development of a FISH-Based HPV-Associated Cancer Detection Test
    Jane Houldsworth; Fiscal Year: 2013
    ..detected, so providing additional triage of the approximately 2,000,000 women each year in the US who undergo colposcopy for follow-up of abnormal cytology...
  14. Cytology vs at home HPV screening for detection of CIN 2,3,CIS
    Shalini L Kulasingam; Fiscal Year: 2013
    ..are tested for high risk (HR)-HPV DNA followed by in-clinic cytology for triage of HR- HPV positive women to colposcopy. We will also explore the potential utility of triage of HR-HPV positive women by HPV genotyping and/or ..
  15. Clinical Evaluation of Polarized Light Assisted Colposcopy
    Daron G Ferris; Fiscal Year: 2012
    ..b>Colposcopy is the procedure used to evaluate women with abnormal Pap test results...
  16. Emory WIHS CRS - Longitudinal Cohort
    GINA MARIA WINGOOD; Fiscal Year: 2013
    ..HVTN) trials, and from the availability of state-of-the-art research capacity relevant to women's health (colposcopy, DXA and fMRI, carotid intima ultrasound, cardiac CT, local specimen repository, etc.)...
  17. Smart Optical Sensor for Detection of Cervical Cancer In the Developing World
    David Keith Walmer; Fiscal Year: 2012
    ..The desired replacement for cytology and colposcopy would be a low cost, portable and clinically-compatible sensor that can survey the entire cervix and identify ..
  18. When Less is More: Changing Cervical Cancer Screening Guidelines
    Michelle Silver; Fiscal Year: 2013
    ..In 2012, the US Preventive Service Task Force (USPTF), American Cancer Association (ACS), American Society for Colposcopy and Cervical Cytology (ASCCP), and American Society for Clinical Pathology (ASCP) updated the guidelines for ..
  19. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    ..b) Assessment of CAP distribution after vaginal application in monkeys using chemically tagged CAP and colposcopy, and magnetic resonance imaging (MRI); and c) Evaluate the efficacy of CAP against infection with pathogenic X4- ..
  20. DNA methylation markers for cervical intraepithelial neoplasia III
    Qinghua Feng; Fiscal Year: 2009
    ..higher sensitivity and specificity than cytology and HR-HPV tests, and will have clinical utility in reducing colposcopy referral rate for women with a cytology diagnosis of ASC-US and a positive HR-HPV test...
  21. Economic spectroscopic evaluation of Cervical Cancer
    Mark Faupel; Fiscal Year: 2011
    ..Our test is intended for use prior to colposcopy by a trained healthcare professional (e.g...
  22. Development of a FISH-Based HPV-Associated Cancer Detection Test
    Jane Houldsworth; Fiscal Year: 2009
    ..detected, so providing additional triage of the approximately 2,000,000 women each year in the US who undergo colposcopy for follow-up of abnormal cytology...
  23. Development of Dendrimer and Combination Microbicides
    Jeremy Paull; Fiscal Year: 2009
    ..Unfortunately colposcopy is relatively insensitive and biopsies are invasive...
  24. PREGNANCY OUTCOME AFTER TREATMENT OF CERVICAL DYSPLASIA
    Lynn Sadler; Fiscal Year: 2001
    ..The cohort will consist of all women less than 45 years of age seen at the Colposcopy Clinic of Greenlane Hospital in Auckland, New Zealand, from 1989 through June 1998 who subsequently carried a ..
  25. Folate, Smoking, Race and Cervical Cancer Risk
    Capri Mara Fillmore; Fiscal Year: 2004
    ..At three colposcopy clinics, 1500 women (50 percent black and 50 percent white race) will fill out a questionnaire on frequency of ..
  26. RETINIODS AND INTERMEDIATE BIOMARKERS FOR CIN I AND II
    Mack Ruffin; Fiscal Year: 1999
    ..Subjects will undergo colposcopy with biopsy at baseline and three months after four day therapy with atRA...
  27. LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS
    Michael Berns; Fiscal Year: 2002
    ..Eligible patients will undergo colposcopy, cytology, and photographic documentation, and colposcopic guided biopsy of abnormal lesions...
  28. EFFICACY OF TELEMEDICINE COLPOSCOPY
    Daron Ferris; Fiscal Year: 1999
    ..on the Health Belief Model and simulated case scenarios administered after the initial and cross validation colposcopy sessions...
  29. Guidelines--Manage Cervical Cytological Abnormalities
    Thomas Wright; Fiscal Year: 2001
    ..The American Society of Colposcopy and Cervical Pathology (ASCAP) will hold a workshop on September 6-9, 2001 in Bethesda, MD at the NIH to develop ..
  30. HPV and HTLV Infection in Female Sex Workers in Peru
    Joseph Zunt; Fiscal Year: 2009
    ..Cervical and serological samples will be obtained to test for HPV,HTLV, and other STI. Digital colposcopy will be performed to evaluate for cervical ectopy...
  31. SPONTANEOUS REGRESSION BIOMARKERS IN CERVIX DYSPLASIA
    Gloria Ho; Fiscal Year: 2003
    ..Women will be recruited from the colposcopy clinics of 3 hospitals associated with the Albert Einstein College of Medicine and followed at 3-month intervals ..
  32. Telecolposcopy in a Primary Care Women's Health Clinic
    Ana Maria Lopez; Fiscal Year: 2006
    ..Patients with an abnormal Pap smear and no visible lesion on visual cervical inspection are referred to colposcopy. The colposcope is a magnifying instrument that can directly detect dysplastic lesions of the cervix...
  33. DETROIT CANCER CONTROL INTERVENTION PROJECT
    Robert Burack; Fiscal Year: 1993
    ..The project will a) establish accessible and reduced-cost cervical cytology, colposcopy and mammography units, b) prompt procedure-due patients (via mailed notices) to visit a primary care study site, ..
  34. Time-Resolved Imaging of Cervical Cancer Acetowhitening
    KEVIN SCHOMACKER; Fiscal Year: 2003
    ..of timed image acquisition, wavelength filtered light and ace to whitening kinetics to improve the accuracy of colposcopy for the routine clinical diagnosis of cervical cancer...
  35. Improved Macaque Safety Model for Topical Microbicides: Post-coital Assessments
    Dorothy L Patton; Fiscal Year: 2011
    ..In this model, measures of product safety include cervicovaginal colposcopy, vaginal microbiologic evaluation, and vaginal pH monitoring...
  36. Impact of LEEP on cervical length and secretions
    Audrey Saftlas; Fiscal Year: 2007
    ..For this aim, untreated women (n=50) who had a colposcopy with punch biopsy will be recruited from the same clinic to serve as a comparison group...
  37. THINPREP HPV IN SITU HYBRIDIZATION WITH PNA PROBES
    Menashi Cohenford; Fiscal Year: 1999
    ..e., requiring follow up colposcopy or biopsy. Phase III will focus on product development and clinical trials...
  38. Smoking Cessation for Women at Risk of Cervical Cancer
    Jessica Whiteley; Fiscal Year: 2004
    ..Counseling regarding smoking cessation may be of particular benefit for women undergoing screening at a colposcopy clinic for the evaluation of an abnormal Papanicolaou (Pap) smear...
  39. PSYCHOLOGICAL INFLUENCES ON IMMUNE RESPONSES TO HPV
    Carolyn Fang; Fiscal Year: 2001
    ..Sixty-two women referred for a follow-up colposcopy will complete baseline psychosocial assessments and provide a blood sample (for immune assays) prior to their ..
  40. Aberrant DNA Methylation as a Biomarker of HSIL in Liquid-based Pap Tests
    KAREN GUSTAFSON; Fiscal Year: 2007
    ..the high prevalence of oncogenic HPV (>80%) and, as a result, all women with ASC-H and LSIL are referred to colposcopy. The risk of overtreatment and unnecessary costs related to this management strategy underscore the need for ..
  41. 3D Tracking for OCT Image Fusion in Gynecological Diagnosis
    Roger McNichols; Fiscal Year: 2009
    ..The system will combine optical coherence tomography (OCT) imaging with traditional colposcopy (with or without aceto-whitening) and/or fluorescence imaging to allow highly detailed morphological analysis of ..
  42. RANDOMIZED TRIAL ON THE CLINICAL MANAGEMENT OF
    DARRON FERRIS; Fiscal Year: 1999
    ..The Contractor shall be responsible for overseeing the quality of all aspects of the Trial involving colposcopy and the taking of cervical biopsies...
  43. HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIA
    Jeffrey Weber; Fiscal Year: 2003
    ..primary end-point of the phase II trial will be digitally determined regression of the area of CIN determined at colposcopy. Other end-points will include: disappearance of the virus in a specimen resected by LEEP one month after the ..
  44. MICROHOLOGRAPHIC DIAGNOSIS OF CERVICAL NEOPLASIA
    Gil Raviv; Fiscal Year: 1990
    ..The instrument will be designed in a manner and shape that is compatible with current instrumentation in colposcopy. During Phase I of the proposed research project the main features of the design will be demonstrated and the ..
  45. SMOKING CESSATION TO REDUCE CERVICAL CANCER RISK
    Paul Greene; Fiscal Year: 2001
    ..recruit 220 current smokers ((10 cigarettes/day) with oncogenic HPV from the University of Alabama at Birmingham Colposcopy Clinic and randomly assign them to one of two treatment conditions: 1)usual care (UC); or 2) smoking cessation ..
  46. DIGITAL IMAGING COLPOSCOPY
    BRIAN CRAINE; Fiscal Year: 1990
    ..In the meantime, we will conduct a systematic analysis of the images to provide evaluation of the usefulness of the existing digital colposcope and to promote development of algorithms which will further improve the system...
  47. ACCISS: Activating Collaborative CIS Support Services
    Bonnie Spring; Fiscal Year: 2007
    ..The RCT will randomize approximately 500 women just scheduled for colposcopy at the two clinics to two conditions involving different letters from the provider...
  48. SPECTROSCOPIC COLPOSCOPY FOR TISSUE CHARACTERIZATION
    ERIC CRAINE; Fiscal Year: 1992
    ..The commercial potential is considered to be excellent since the proposed effort builds incrementally on existing clinical hardware and newly emerging research techniques...
  49. CANCER CONTROL--DEVELOPMENTAL AND SUPPORT GRANT
    RICHARD GAMS; Fiscal Year: 1980
    ..demonstration projects: an OB-GYN Nurse Practitioner Program which has graduated 104 students as of July 1978; a Colposcopy Program which has established 14 colposcopy clinics in Alabama; and a General Oncology Nurse Practitioner ..
  50. MULTIMODAL SPECTROSCOPIC EVALUATION OF CERVICAL CANCER
    Shabbir Bambot; Fiscal Year: 2001
    ..the potential to replace or aid the current Pap test as well as to replace the current methods of colposcopy, biopsy and histology. The target physician group for the cervical application is the Ob-Gyn segment...
  51. NATURAL HISTORY OF HPV--INFECTION TO NEOPLASIA
    Anna Barbara Moscicki; Fiscal Year: 2004
    ..The understanding of both local and systemic immune responses to initial and subsequent HPV infections may be key in vaccine or therapeutic developments. ..
  52. Natural History of CIN2 in Adolescents
    Anna Barbara Moscicki; Fiscal Year: 2007
    ..to observe young women with a biopsy verified CIN-2 lesion at 4 month intervals with HPV testing, cytology and colposcopy, b) examine risk factors using interview and chart review and c) examine estrogen and progesterone receptor ..
  53. Surveillance Strategies Following Treatment for CIN
    Joy Melnikow; Fiscal Year: 2007
    ..Alternative strategies for post-treatment surveillance will be evaluated. [unreadable] [unreadable] [unreadable]..
  54. TAMOXIFEN & BREAST CANCER--ACCEPTANCE/COST EFFECTIVENESS
    Joy Melnikow; Fiscal Year: 2002
    ..abstract_text> ..
  55. Mentored Investigator Award in Women's Health
    Lori Boardman; Fiscal Year: 2005
    ....
  56. A Collaborative Approach to Control Hypertension in Diabetes (COACH-D)
    MELISSA MCKEE; Fiscal Year: 2008
    ..This proposal is for secondary prevention of diabetes complications, targeting a population known for health disparities and a high burden from this chronic disease. [unreadable] [unreadable]..
  57. Vaginal Douching in Latina Women and Adolescents
    MELISSA MCKEE; Fiscal Year: 2006
    ..abstract_text> ..
  58. WIH/Brown Epidemiology/Clinical Trials Training Program
    Lori Boardman; Fiscal Year: 2006
    ..This multidisciplinary program will provide a new cadre of ob/gyn investigators who will further the scientific database in reproductive health. ..
  59. EPIDEMIOLOGY OF HPV16/18 VARIANTS IN CERVICAL NEOPLASIA
    Long Fu Xi; Fiscal Year: 2003
    ..By including data from only those women enrolled in the immediate colposcopy arm of ALTS, we will develop precise estimates of the association between HPV 1 6 and IS variants and cervical ..
  60. Injury from Sexual Assault: Addressing Health Disparity
    Marilyn S Sommers; Fiscal Year: 2010
    ..Public Health Relevance: Violence against women is a silent epidemic. The forensic exam used to collect evidence after rape needs to be equally sensitive for females with dark skin as well as females with light skin. ..
  61. Depression Screening & Treatment in Ovarian Cancer
    Eileen Shinn; Fiscal Year: 2007
    ..Drs. Rehm and Taylor will co-supervise Dr. Shinn in the CBT administration. This intervention is innovative and has not been done before with any group of cancer patients, including ovarian cancer patients. ..