psychosurgery

Summary

Summary: Treatment of chronic, severe and intractable psychiatric disorders by surgical removal or interruption of certain areas or pathways in the brain, especially in the prefrontal lobes.

Top Publications

  1. ncbi Psychosurgery for self-injurious behavior in Tourette's disorder
    Sharadamani Anandan
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 0193, USA
    J Child Adolesc Psychopharmacol 14:531-8. 2004
  2. ncbi From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research
    Joseph J Fins
    Division of Medical Ethics, Departments of Medicine and Public Health, Weill Medical College of Cornell University, New York Weill Cornell Medical Center, 525 East 68th Street, F 173, New York, NY, USA
    Neurosurg Clin N Am 14:303-19, ix-x. 2003
  3. ncbi Psychosurgery: avoiding an ethical redux while advancing a therapeutic future
    Joseph J Fins
    Division of Medical Ethics, New York Presbyterian Weill Cornell Medical Center, New York, New York 10021, USA
    Neurosurgery 59:713-6. 2006
  4. ncbi 'Psychosurgery' in renaissance art
    C G Gross
    Dept of Psychology, Princeton University, NJ 08540, USA
    Trends Neurosci 22:429-31. 1999
  5. ncbi Dr. Gottlieb Burckhardt--the pioneer of psychosurgery
    J L Stone
    Division Neurosurgery, Department of Surgery, Cook County Hospital and Hektoen Institute for Medical Research, and Loyola University, Rush Medical College, Chicago, IL, USA
    J Hist Neurosci 10:79-92. 2001
  6. ncbi Seizure outcome after temporal lobectomy: current research practice and findings
    A M McIntosh
    Epilepsy Research Institute, Austin and Repatriation Medical Centre, Heidelberg, Melbourne, Australia
    Epilepsia 42:1288-307. 2001
  7. doi Neural stimulation successfully treats depression in patients with prior ablative cingulotomy
    Joseph S Neimat
    Toronto Western Hospital, 399 Bathurst St, WW4 425, Toronto, Ontario M5T 2S8, Canada
    Am J Psychiatry 165:687-93. 2008
  8. ncbi Psychosurgery and deep brain stimulation as ultima ratio treatment for refractory depression
    Georg Juckel
    Department of Psychiatry Psychotherapy and Psychosomatic Medicine, Ruhr University, Alexandrinenstr 1, Bochum 44791, Germany
    Eur Arch Psychiatry Clin Neurosci 259:1-7. 2009
  9. ncbi Magnetic resonance imaging-guided stereotactic limbic leukotomy for treatment of intractable psychiatric disease
    Alonso Montoya
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neurosurgery 50:1043-9; discussion 1049-52. 2002
  10. ncbi Emotion recognition from dynamic emotional displays following anterior cingulotomy and anterior capsulotomy for chronic depression
    Nathan Ridout
    Clinical and Cognitive Neurosciences, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Neuropsychologia 45:1735-43. 2007

Research Grants

  1. PHYSIOLOGIC STUDIES OF ANGER IN DEPRESSED PATIENTS
    Darin Dougherty; Fiscal Year: 2002
  2. BRAIN ACTIVATION PROFILES IN DYSLEXIA--A MEG STUDY
    Andrew Papanicolaou; Fiscal Year: 2003
  3. CONTRIBUTIONS OF MEG TO THE SURGICAL MGMT OF EPILEPSY
    Andrew Papanicolaou; Fiscal Year: 2003
  4. Integration of MSI/fMRI Studies of Reading
    Andrew Papanicolaou; Fiscal Year: 2004
  5. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
  6. DISORDERS OF NEURONAL MIGRATION AND EPILEPSY
    STEVEN ROPER; Fiscal Year: 2005
  7. Semantic Memory and MRI Volumetrics in Epilepsy
    Brian Bell; Fiscal Year: 2005
  8. Improving Learning in MS: A Randomized Clinical Trial
    Nancy Chiaravalloti; Fiscal Year: 2008

Detail Information

Publications174 found, 100 shown here

  1. ncbi Psychosurgery for self-injurious behavior in Tourette's disorder
    Sharadamani Anandan
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch at Galveston, Galveston, Texas 77555 0193, USA
    J Child Adolesc Psychopharmacol 14:531-8. 2004
    ..Understandably, there are few reports concerning psychosurgery in children and adolescents for any condition or disorder...
  2. ncbi From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research
    Joseph J Fins
    Division of Medical Ethics, Departments of Medicine and Public Health, Weill Medical College of Cornell University, New York Weill Cornell Medical Center, 525 East 68th Street, F 173, New York, NY, USA
    Neurosurg Clin N Am 14:303-19, ix-x. 2003
    ..That era of psychosurgery ended with widespread condemnation, congressional calls for a ban, and avow that history should never repeat ..
  3. ncbi Psychosurgery: avoiding an ethical redux while advancing a therapeutic future
    Joseph J Fins
    Division of Medical Ethics, New York Presbyterian Weill Cornell Medical Center, New York, New York 10021, USA
    Neurosurgery 59:713-6. 2006
  4. ncbi 'Psychosurgery' in renaissance art
    C G Gross
    Dept of Psychology, Princeton University, NJ 08540, USA
    Trends Neurosci 22:429-31. 1999
    ..As trepanation for head injury and mental disease was actually carried out in Europe at this time, another interpretation of these works is that they are derived from a common medical practice of the day...
  5. ncbi Dr. Gottlieb Burckhardt--the pioneer of psychosurgery
    J L Stone
    Division Neurosurgery, Department of Surgery, Cook County Hospital and Hektoen Institute for Medical Research, and Loyola University, Rush Medical College, Chicago, IL, USA
    J Hist Neurosci 10:79-92. 2001
    The first attempt at psychosurgery--intentional damage to the intact brain for the relief of mental illness--was undertaken in 1888 by the Swiss psychiatrist Gottlieb Burckhardt...
  6. ncbi Seizure outcome after temporal lobectomy: current research practice and findings
    A M McIntosh
    Epilepsy Research Institute, Austin and Repatriation Medical Centre, Heidelberg, Melbourne, Australia
    Epilepsia 42:1288-307. 2001
    ..The systematic review of possible risk factors for seizure recurrence provides a basis for planning further research...
  7. doi Neural stimulation successfully treats depression in patients with prior ablative cingulotomy
    Joseph S Neimat
    Toronto Western Hospital, 399 Bathurst St, WW4 425, Toronto, Ontario M5T 2S8, Canada
    Am J Psychiatry 165:687-93. 2008
  8. ncbi Psychosurgery and deep brain stimulation as ultima ratio treatment for refractory depression
    Georg Juckel
    Department of Psychiatry Psychotherapy and Psychosomatic Medicine, Ruhr University, Alexandrinenstr 1, Bochum 44791, Germany
    Eur Arch Psychiatry Clin Neurosci 259:1-7. 2009
    ..g., nucleus accumbens, the lateral habenula or cortical areas. Nevertheless, the reticence toward psychosurgery, even for those patients suffering from the most debilitating forms of depression, still prevails, even though ..
  9. ncbi Magnetic resonance imaging-guided stereotactic limbic leukotomy for treatment of intractable psychiatric disease
    Alonso Montoya
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neurosurgery 50:1043-9; discussion 1049-52. 2002
    ..To assess the efficacy and complication rates of magnetic resonance imaging-guided stereotactic limbic leukotomy for the treatment of intractable major depressive disorder (MDD) and obsessive-compulsive disorder (OCD)...
  10. ncbi Emotion recognition from dynamic emotional displays following anterior cingulotomy and anterior capsulotomy for chronic depression
    Nathan Ridout
    Clinical and Cognitive Neurosciences, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Neuropsychologia 45:1735-43. 2007
    ..It is plausible that the observed deficit in emotion recognition accuracy was a consequence of impaired attentional control, which may have been a result of the surgical lesions to the anterior cingulate cortex...
  11. ncbi From prefrontal leukotomy to deep brain stimulation: the historical transformation of psychosurgery and the emergence of neuroethics
    Joshua J Wind
    Department of Neurosurgery, The George Washington University School of Medicine, Washington, DC 20037, USA
    Neurosurg Focus 25:E10. 2008
    The history of psychosurgery is described and analyzed. This historical perspective largely begins with analysis of the work of Egas Moniz in the development of the leukotomy, and follows the rise and fall of its popularity in the 1900s...
  12. ncbi Review of long-term results of stereotactic psychosurgery
    Moon Chan Kim
    Department of Neurosurgery, Kangnam St Mary s Hospital, The Catholic University of Korea, College of Medicine, Seoul, ROK
    Neurol Med Chir (Tokyo) 42:365-71. 2002
    Stereotactic psychosurgery is an effective method for treating some medically intractable psychiatric illnesses. However, it is unfamiliar and the long-term clinical results have not been reported in Asia...
  13. ncbi Psychosurgery: past, present, and future
    George A Mashour
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Brain Res Brain Res Rev 48:409-19. 2005
    b>Psychosurgery, the neurosurgical treatment of psychiatric disease, has a history dating back to antiquity, and involves all of the clinical neurosciences...
  14. ncbi Sixty years of psychosurgery: its present status and its future
    P Sachdev
    Neuropsychiatric Institute, Prince Henry Hospital, Little Bay, New South Wales, Australia
    Aust N Z J Psychiatry 31:457-64. 1997
    After its introduction 60 years ago, psychosurgery witnessed a remarkable rise followed by a decline. In the 1990s, it is a marginal treatment practised by a few psychiatrists in some specialised centres around the world...
  15. ncbi Psychosurgery for obsessive-compulsive disorder -- concerns remain
    Susanne Bejerot
    Acta Psychiatr Scand 107:241-3. 2003
  16. ncbi Psychosurgery: a historical overview
    R P Feldman
    Department of Neurological Surgery, Albert Einstein College of Medicine, Yeshiva University, New York, New York, USA
    Neurosurgery 48:647-57; discussion 657-9. 2001
    ..of the spirit to the millimeter accuracy of stereotactic instruments currently used in the operating room, psychosurgery has enjoyed enthusiastic support as well as experiencing scorn...
  17. ncbi Contemporary psychosurgery and a look to the future
    R P Feldman
    Department of Neurological Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA
    J Neurosurg 95:944-56. 2001
    Despite a long and controversial history, psychosurgery has persisted as a modern treatment option for some severe, medically intractable psychiatric disorders. The goal of this study was to review the current state of psychosurgery.
  18. ncbi From psychosurgery to neuromodulation: deep brain stimulation for intractable Tourette syndrome
    Irene Neuner
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    World J Biol Psychiatry 10:366-76. 2009
    ..In intractable patients, neuromodulation using deep brain stimulation (DBS) has widely replaced psychosurgery. Three different key structures are defined for DBS, the medial portion of the thalamus, the globus pallidus ..
  19. ncbi Lateralization of epileptic foci by neuropsychological testing in mesial temporal lobe epilepsy
    Hongkeun Kim
    Department of Rehabilitation Psychology, Daegu University, Daegu, South Korea
    Neuropsychology 18:141-51. 2004
    ..With a stringent cutoff criterion, the multiple neuropsychological predictors considered in combination yielded a sensitivity of 15% and a PPV of 93%, and with a less stringent cutoff criterion, a sensitivity of 37% and a PPV of 83%...
  20. ncbi Memory for faces dissociates from memory for location following anterior temporal lobectomy
    Nancy D Chiaravalloti
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Brain Cogn 54:35-42. 2004
    ..Lesions in the right MTL, adjacent to the cortical structures believed to be specialized for facial recognition, specifically impair the memory encoding of new faces, but not spatial locations...
  21. ncbi Foramen ovale recordings: a presurgical investigation in epilepsy
    U C Wieshmann
    Magnetic Resonance and Image Analysis Research Centre, Walton Centre for Neurology and Neurosurgery, University of Liverpool, UK
    Eur Neurol 49:3-7. 2003
    ..No useful localizing information was added with foramen ovale recordings in MRI-negative patients...
  22. ncbi Prognostic implications of seizure recurrence in the first year after anterior temporal lobectomy
    Kurupath Radhakrishnan
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Epilepsia 44:77-80. 2003
    ..Seizure recurrence after anterior temporal lobectomy (ATL) incites concerns of whether seizures will eventually be successfully controlled. Our study evaluated the prognostic significance of seizure recurrence in the first year after ATL...
  23. ncbi Material-specific memory in temporal lobe epilepsy: effects of seizure laterality and language dominance
    Hongkeun Kim
    Department of Rehabilitation Psychology, Daegu University, South Korea
    Neuropsychology 17:59-68. 2003
    ..Relative sparing of verbal memory capacity in LTLE patients with NLHLD may reflect interhemispheric reorganization of verbal memory function...
  24. ncbi Lateralized-temporal-lobe-lesion effects on learning and memory: examining the contributions of stimulus novelty and presentation mode
    Marie Antoinette Redoblado
    Department of Psychology, Macquarie University, Sydney, Australia
    J Clin Exp Neuropsychol 25:36-48. 2003
    ..written) on word-list learning was examined. We found that novelty enhanced material-specific-side-of lesion effects and that the LTL group had greater difficulty in learning spoken than written words...
  25. ncbi Hamartomas and epilepsy: clinical and imaging characteristics
    B Diehl
    Department of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Seizure 12:307-11. 2003
    ..We present the clinical presentation and imaging findings of this rare entity...
  26. ncbi Long-term outcome of nonsurgical candidates with medically refractory localization-related epilepsy
    Linda M Selwa
    Department of Neurology, University of Michigan Medical School, 1500 East Medical Center Drive, 1914 0316 Taubman, Ann Arbor, MI 48109 0316, USA
    Epilepsia 44:1568-72. 2003
    ..In this study, we evaluated the outcome of medical treatment in patients with medically refractory partial epilepsy who were evaluated for possible epilepsy surgery but deemed to be inadequate surgical candidates...
  27. ncbi Panic attack semiology in right temporal lobe epilepsy
    Mona Sazgar
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
    Epileptic Disord 5:93-100. 2003
    ..We present a case series to demonstrate the association of ictal panic and anxiety symptoms with partial seizures lateralized to the right temporal lobe...
  28. ncbi The goal of epilepsy therapy: no seizures, no side effects, as soon as possible
    Jerome Engel
    Department of Neurology, David Geffen School of Medicine, University of Califorina, Los Angeles, Los Angeles, Califorina, USA
    CNS Spectr 9:95-7. 2004
  29. ncbi Stereotactic treatment of refractory obsessive compulsive disorder by bilateral capsulotomy with 3 years follow-up
    Kangyong Liu
    Department of Neurology, Affiliated Second Hospital, Soochow University, Suzhou, Jiangsu, China
    J Clin Neurosci 15:622-9. 2008
    ..This promising technique may also improve anxiety and depression in addition to OCD. OCD patients who have not responded to medication, psychotherapy or behavioral therapy might benefit from MRI-guided stereotactic bilateral capsulotomy...
  30. ncbi The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy
    John F Kerrigan
    Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Semin Pediatr Neurol 12:119-31. 2005
    ..Refractory epilepsy associated with HH is the premier human model for subcortical epilepsy and an excellent model for secondary epileptogenesis and epileptic encephalopathy...
  31. ncbi Hippocampal transection for treatment of left temporal lobe epilepsy with preservation of verbal memory
    Hiroyuki Shimizu
    Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu, Tokyo 183 0042, Japan
    J Clin Neurosci 13:322-8. 2006
    ..The accumulation of cases and follow-up of greater duration will be necessary to precisely confirm the efficacy of this new technique...
  32. ncbi Tuberous sclerosis complex: a review of the management of epilepsy with emphasis on surgical aspects
    Mary B Connolly
    Division of Pediatric Neurology, Department of Pediatrics, University of British Columbia and British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Childs Nerv Syst 22:896-908. 2006
    ..To review the management of epilepsy in patients with tuberous sclerosis complex (TSC) with an emphasis on surgical aspects, neuropathology, and pathogenesis...
  33. ncbi Pediatric intractable epilepsy syndromes: reason for early surgical intervention
    Shiyong Liu
    Department of Neurosurgery, Xinqiao Hospital, The Third Military Medical University, Chongqing, PR China
    Brain Dev 29:69-78. 2007
    ....
  34. ncbi Right hemisphere language mapping in patients with bilateral language
    Rosette A Jabbour
    Minnesota Epilepsy Group, PA, St Paul, MN, USA
    Epilepsy Behav 6:587-92. 2005
    ..Herein, we report six patients who underwent electrocortical stimulation (ECS) for language mapping following implantation of a right subdural electrode array (SEA)...
  35. ncbi Memory and intelligence outcome following surgery for intractable temporal lobe epilepsy: relationship to seizure outcome and evaluation using a customized neuropsychological battery
    Sujoy K Sanyal
    Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi 110 029, India
    Epilepsy Behav 6:147-55. 2005
    ..The same finding was not observed in patients undergoing left temporal surgery...
  36. ncbi Frontal lobe epilepsy
    Christoph Kellinghaus
    Dept of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epileptic Disord 6:223-39. 2004
    ..Patients with frontal lobe epilepsy who do not respond to anticonvulsive medication, and who are not eligible for epilepsy surgery may benefit from alternative approaches such as electrical brain stimulation...
  37. ncbi [Surgical treatment of lesional temporal lobe epilepsy]
    Li Xin Cai
    Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, The Capital University of Medical Sciences, Beijing 100053, China
    Zhonghua Wai Ke Za Zhi 45:103-5. 2007
    ..To discuss the presurgical evaluation and surgical treatment of lesional temporal lobe epilepsy (LTLE)...
  38. ncbi Personality changes following temporal lobectomy for epilepsy. 1957
    Denis Hill
    Epilepsy Behav 5:603-10. 2004
  39. ncbi Commentary on "Personality changes following temporal lobectomy for epilepsy"
    Alan B Ettinger
    Division of EEG and Epilepsy, Department of Neurology, Long Island Jewish Medical Center, 270 05 76th Avenue, New Hyde Park, NY 11040, USA
    Epilepsy Behav 5:601-2. 2004
  40. ncbi Resection extent versus postoperative outcomes of seizure and memory in mesial temporal lobe epilepsy
    Eun Yeon Joo
    Department of Neurology, Samsung Medical Center and Center for Clinical Medicine, SBRI, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, Korea
    Seizure 14:541-51. 2005
    ..To investigate the effects of the resection of hippocampus and temporal neocortex on postsurgical seizure and memory outcomes in mesial temporal lobe epilepsy (mTLE) patients...
  41. ncbi Interictal triple ECoG characteristics of temporal lobe epilepsies: An intraoperative ECoG analysis correlated with surgical outcome
    H Stefan
    Epilepsy Center, Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Clin Neurophysiol 119:642-52. 2008
    ..We have systematically investigated different characteristic epileptiform activities in intraoperative ECoG and correlated them to postoperative outcome...
  42. ncbi Temporal lobotomy in the surgical management of epilepsy: technical report
    Joseph R Smith
    Department of Neurosurgery, Medical College of Georgia, Augusta, 30912, USA
    Neurosurgery 54:1531-4; discussion 1534-6. 2004
    ..To describe the technique of temporal lobotomy and demonstrate that it may produce results equivalent to anterior temporal lobectomy in the control of drug-resistant complex partial seizures of anterior temporal lobe origin...
  43. ncbi Extratemporal resection for childhood epilepsy
    D Barry Sinclair
    Comprehensive Epilepsy Program, University of Alberta, Edmonton, Alberta, Canada
    Pediatr Neurol 30:177-85. 2004
    ..A wide range of developmental pathology was observed including focal cortical dysplasia, brain tumors, and lesions with neurocutaneous syndromes. Many families reported improvement in behavior and psychosocial function after surgery...
  44. ncbi Frontal lobe epilepsy in childhood
    D Barry Sinclair
    Comprehensive Epilepsy Program, University of Alberta, Edmonton, Alberta, Canada
    Pediatr Neurol 30:169-76. 2004
    ..The condition is often misdiagnosed as a sleep disorder or psychiatric problem. Seizures are difficult to control but may respond to carbamazepine, valproic acid, or epilepsy surgery...
  45. ncbi Remifentanil-induced spike activity as a diagnostic tool in epilepsy surgery
    L Grønlykke
    Deaprtment of Clinical Neurophysiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Acta Neurol Scand 117:90-3. 2008
    ..To assess the value of remifentanil in intraoperative evaluation of spike activity in patients undergoing surgery for mesial temporal lobe epilepsy (MTLE)...
  46. pmc Hemifacial motor and crying seizures of temporal lobe onset: case report and review of electro-clinical localisation
    R E Hogan
    Department of Neurology, Saint Louis University School of Medicine, Epilepsy Offices, St Louis, MO 63104, USA
    J Neurol Neurosurg Psychiatry 77:107-10. 2006
    ..To report a case of temporal lobe epilepsy with clinical presentation of paroxysmal episodes of "tightness" over the right hemiface, and ictal crying, and review electroclinical localisation of this phenomenon...
  47. ncbi Surgical versus medical treatment for severe epilepsy: consequences for intellectual functioning in children and adults. A follow-up study
    Helge Bjørnaes
    The National Centre for Epilepsy, Sandvika, Norway
    Seizure 11:473-82. 2002
    ....
  48. ncbi [Localizing and prognosis value of 99Tcm-ECD spect in patients with refractory temporal lobe epilepsies]
    A Crespel
    Service Explorations Neurologiques et Epileptologie, , Montpelier
    Rev Neurol (Paris) 157:639-48. 2001
    ..Unilateral mesial temporal hyperperfusion associated with hypoperfusion of contralateral mesial structures evidenced by ictal SPECTs appear to be preoperative criteria for a successful outcome after surgery...
  49. ncbi The effects of remifentanil on epileptiform discharges during intraoperative electrocorticography in patients undergoing epilepsy surgery
    C T Wass
    Department of Anesthesiology, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905, USA
    Epilepsia 42:1340-4. 2001
    ..Should this be the case, we envision remifentanil has the potential to supplant other opioids (e.g., alfentanil) during ECoG-guided ES...
  50. ncbi Material-specific deficits in "remembering" in patients with unilateral temporal lobe epilepsy and excisions
    David A Moscovitch
    Department of Psychology, University of Toronto, Toronto, Canada
    Neuropsychologia 40:1335-42. 2002
    ..We offer this as a novel interpretation of the "remember-know" literature...
  51. ncbi Seizures in family members of patients with hippocampal sclerosis
    R S Briellmann
    Epilepsy Research Institute, Austin and Repatriation Medical Center, University of Melbourne, Australia
    Neurology 57:1800-4. 2001
    ..CONCLUSION: FH of seizures, particularly febrile convulsions, are a risk factor for TLE with HS. These data suggest that a variety of genes contributing to epilepsy phenotypes in relatives may be involved in the pathogenesis of HS...
  52. ncbi A selective deficit for living things after temporal lobectomy for relief of epileptic seizures
    L Luckhurst
    University of Kent, Canterbury, Kent, United Kingdom
    Brain Lang 79:266-96. 2001
    ..We argue that damage to the temporal lobe impairs lexical retrieval most strongly for living things and that the anterior temporal cortices are convergence zones particularly necessary for retrieving the names of living things...
  53. pmc Human "memories" can be evoked by stimulation of the lateral temporal cortex after ipsilateral medial temporal lobe resection
    J L Moriarity
    Department of Neurosurgery, Meyer Building 7-113, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287-7713, USA
    J Neurol Neurosurg Psychiatry 71:549-51. 2001
    ..To our knowledge, this is the first documented case of experiential phenomena evoked by cortical stimulation in the absence of the ipsilateral medial temporal lobe...
  54. ncbi Effect of age of onset of temporal lobe epilepsy on the severity and the nature of preoperative memory deficits
    Véronique Lespinet
    Laboratoire de Sciences Cognitives, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Neuropsychologia 40:1591-600. 2002
    ..These results may be interpreted in the framework of ontogenesis theories of hemispheric specialization...
  55. ncbi Category-specific naming deficits for objects and actions: semantic attribute and grammatical role hypotheses
    Lisa H Lu
    Department of Psychology, Chung Yuan Christian University, Chung Li, Taiwan, TOC
    Neuropsychologia 40:1608-21. 2002
    ..These connections may mediate activation of action-related information (i.e. movement plan and/or motor use) that facilitates the retrieval of names for tools/implements and human actions...
  56. ncbi [Memory disorders after unilateral cerebral lesions]
    P Metzler
    Unfallkrankenhaus Berlin, Klinik für Neurologie mit Stroke Unit und Frührehabilitation, Warener Strasse 7, 12683 Berlin
    Nervenarzt 73:355-63. 2002
    ..Possible reasons for these differing results with visual-spatial memory deficits are still under discussion...
  57. ncbi Quantitative and qualitative interpretation of neuropsychological data in the assessment of temporal lobectomy candidates
    M Ogden-Epker
    University of Texas Southwestern Medical Center, Neurospychology, Dallas, TX 75390-8898, USA
    Clin Neuropsychol 15:183-95. 2001
    ....
  58. ncbi Quantification of F-18 FDG PET images in temporal lobe epilepsy patients using probabilistic brain atlas
    K W Kang
    Department of Nuclear Medicine, Seoul National University College of Medicine, Korea
    Neuroimage 14:1-6. 2001
    ..The asymmetric indices obtained by taking the product of the statistical probability anatomical map and FDG PET, correlated well with visual assessment in mTLE patients. SPAM is useful for the quantification of VOIs in functional images...
  59. ncbi Spanish language mapping using MEG: a validation study
    Fernando Maestu
    Magnetoencephalography Center, Dr Pérez Modrego, Cognitive Process, Universidad Complutense Madrid, Madrid, Spain
    Neuroimage 17:1579-86. 2002
    ..These results suggests that MEG-based language mapping can play an important role in presurgical clinical evaluation...
  60. ncbi Surgical treatment of epilepsies
    J Zentner
    Department of Neurosurgery, University of Freiburg, Freiburg, Germany
    Acta Neurochir Suppl 84:27-35. 2002
    ..Major problems include the definition of the epileptogenic area with respect to optimal seizure control and minimum neurological and neuropsychological impairment after surgery...
  61. ncbi Lateralizing ability of single-voxel proton mr spectroscopy in hippocampal sclerosis: comparison with mr imaging and positron emission tomography
    S W Park
    Department of Radiology, Seoul National University College of Medicine, Korea
    AJNR Am J Neuroradiol 22:625-31. 2001
    ..CONCLUSION: MRS may be used as an adjunct tool in the evaluation of hippocampal sclerosis, like PET, although its sensitivity has to be improved and the clinical significance of bilateral abnormality is still to be determined...
  62. ncbi Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MR imaging
    R L Wolf
    Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    AJNR Am J Neuroradiol 22:1334-41. 2001
    ..This technique is readily combined with routine structural assessment and potentially offers an inexpensive and noninvasive means of screening for asymmetries in interictal mesial temporal lobe function...
  63. ncbi Therapeutic options for treatment-resistant depression
    Richard C Shelton
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    CNS Drugs 24:131-61. 2010
    ..Other nonpharmacological options, such as repetitive transcranial stimulation, deep brain stimulation or psychosurgery, remain experimental and are not widely available...
  64. ncbi A patient with a resistant major depression disorder treated with deep brain stimulation in the inferior thalamic peduncle
    Fiacro Jiménez
    Functional Neurosurgery and Radiosurgery, General Hospital of Mexico, National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    Neurosurgery 57:585-93; discussion 585-93. 2005
    ..The present report explored the effect of electrical stimulation on the inferior thalamic peduncle in a patient with resistant major depression disorder (MDD)...
  65. ncbi Amygdaloid neurosurgery for aggressive behaviour, Sydney, 1967-1977: societal, scientific, ethical and other factors
    Richard White
    Discipline of Psychological Medicine, University of Sydney, Sydney, NSW, Australia
    Australas Psychiatry 17:410-6. 2009
    In 1967, despite escalating international hostility towards psychosurgery, a program of amygdaloid neurosurgery for the reduction of aggressive and self-harming behaviour commenced in Sydney...
  66. ncbi The interaction of delirium and seizures
    M Fink
    Research Department, Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY, USA
    Semin Clin Neuropsychiatry 5:93-7. 2000
    ..delirium is a feature of modern electroconvulsive therapy (ECT), and was a feature of insulin coma therapy and psychosurgery. Case material explores the relationship between psychosis, mania, seizures, and electroencephalogram...
  67. ncbi Amygdaloid neurosurgery for aggressive behaviour, Sydney, 1967-1977: chronological narrative
    Richard White
    Discipline of Psychological Medicine, University of Sydney, Sydney, NSW, Australia
    Australas Psychiatry 17:405-9. 2009
    ..In this paper, this is denoted the Amygdaloid Neurosurgery Project (ANP). The goal of the project was to ameliorate aggressive or self-harming behaviour by selective ablative surgery on the amygdaloid nucleus...
  68. ncbi Neurosurgeons' perspectives on psychosurgery and neuroenhancement: a qualitative study at one center
    Daniel Mendelsohn
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Ontario, Canada
    J Neurosurg 113:1212-8. 2010
    ..The authors sought to gauge the opinions of neurosurgical staff and trainees toward various uses of neuromodulation technology including psychosurgery and neuroenhancement.
  69. ncbi Bilateral stereotactic amygdalotomy for self-mutilation disorder. Case report and review of the literature
    Kostas N Fountas
    Department of Neurosurgery, Medical College of Georgia, Augusta, USA
    Stereotact Funct Neurosurg 85:121-8. 2007
    ..The advances of psychopharmacology along with the existent skepticism of the medical community in regards to psychosurgery have resulted in a dramatic decrease in the number of amygdalotomies performed worldwide...
  70. ncbi Ethical issues in neuroscience
    Thomas Fuchs
    Psychiatric Department, University of Heidelberg, Heidelberg, Germany
    Curr Opin Psychiatry 19:600-7. 2006
    ..The study gives an overview of ethical questions raised by the progress of neuroscience in identifying and intervening in neural correlates of the mind...
  71. ncbi Deep brain stimulation as a new therapeutic approach in therapy-resistant mental disorders: ethical aspects of investigational treatment
    Jens Kuhn
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S135-41. 2009
    ..psychiatric patients raise ethical considerations not only based on the disreputable experiences of the era of psychosurgery. Therefore, it is necessary to implement transparent and well-defined regulations for the protection of the ..
  72. ncbi [Intervening between brain and mind: an ethical analysis of the new possibilities of the neurosciences]
    M Synofzik
    Institut für Ethik und Geschichte in der Medizin, Universitat Tubingen
    Fortschr Neurol Psychiatr 73:596-604. 2005
    ..neuroethical fields: neuroscientific research, neural grafting, psychopharmacology, neuroimaging, neuro- and psychosurgery, and allocation in neuroscience...
  73. ncbi Dr William Sargant (1907-88) and the emergence of physical treatments in British psychiatry
    John A S Beard
    University of Oxford
    J Med Biogr 17:23-9. 2009
    ..Sargant was a flag-bearer for the new treatment methods of insulin coma, electroconvulsive therapy (ECT), psychosurgery and intensive drug therapy...
  74. ncbi [Two Nobel prizes for psychiatry]
    Aleksandar Knezevic
    Institut za psihijatriju, Klinicki centar Vojvodine Novi Sad
    Med Pregl 61:651-2. 2008
    ..Modern achievements in psychiatry have suppresed both psychosurgery of Egas Moniz and malaria treatment of Wagner-Jauregg as methods in the treatment of mental diseases.
  75. ncbi Stereotactic lesioning for mental illness
    M C Kim
    Department of Neurosurgery, College of Medicine, Kangnam St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Acta Neurochir Suppl 101:39-43. 2008
    ..The authors report stereotactically created lesioning by radiofrequency or Cyberknife radiosurgery for patients with mental illness...
  76. ncbi Deep brain stimulation: from neurology to psychiatry?
    Paul Krack
    Movement Disorders Unit, Department of Psychiatry and Neurology, University Hospital Grenoble, France
    Trends Neurosci 33:474-84. 2010
    ..The advent of neuroleptics led to a drastic decline in psychosurgery for several decades...
  77. ncbi [Stereotactic multi-target operation for patients with affective disorder]
    Lian Zhong Wang
    Institute of Psychosurgery of Chinese People s Liberation Army, Department of Neurosurgery, No 463 Hospital of People s Liberation Army, Shenyang 110042, China
    Zhonghua Wai Ke Za Zhi 45:1676-8. 2007
    ..To explore the efficacy and complication of bilateral multi-target radiofrequency lesion operation in patients with affective disorder...
  78. ncbi Lennart Heimer: concepts of the ventral striatum and extended amygdala
    W Jeff Elias
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Neurosurg Focus 25:E8. 2008
    ..of Swedish descent, died last year but left a legacy that will impact the neurosciences and potentially psychosurgery for years to come...
  79. ncbi [Change, transformation, evolution]
    J M Barthélémy
    Universite de Savoie
    Bull Soc Sci Med Grand Duche Luxemb . 2010
    ..and pathological development throughout childhood or at the critical moment of the adolescence period, in psychosurgery or psychobiological practices, then in cases of appearing and disappearing of delusional processes, in the ..
  80. ncbi Treatment-resistant depression: clinical significance, concept and management
    P Sharan
    Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Natl Med J India 11:69-79. 1998
    ..Somatotherapy should be combined in all cases with depression-specific psychotherapy. Psychosurgery should be considered only in truly intractable cases...
  81. ncbi Mental health legislation and psychiatric treatments in NSW: electroconvulsive therapy and deep brain stimulation
    Colleen Loo
    School of Psychiatry, University of NSW, St George Hospital, Gray Street, Kogarah, NSW 2217, Australia
    Australas Psychiatry 18:417-25. 2010
    ..of electroconvulsive therapy (ECT) to the treatment of psychiatric disorders and the prohibition of psychosurgery and deep brain stimulation (DBS) in the NSW Mental Health Act 2007 (MHA), and to examine these restrictions ..
  82. ncbi Neurosurgery for obsessive-compulsive disorder: contemporary approaches
    Renee E Bear
    School of Psychology, Deakin University, Burwood, Victoria, Australia
    J Clin Neurosci 17:1-5. 2010
    ..and non-destructive technique known as deep brain stimulation has coincided with a resurgence in interest in psychosurgery. Contemporary approaches to the surgical management of obsessive-compulsive disorder are discussed, together ..
  83. ncbi A review of the treatment for refractory obsessive-compulsive disorder: from medicine to deep brain stimulation
    David S Husted
    Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL 32610 0256, USA
    CNS Spectr 9:833-47. 2004
    ..magnetic stimulation, invasive but the potentially reversible deep brain stimulation, and irreversible lesioning with ablative psychosurgery. A discussion of the role of psychotherapy in the treatment of OCD is also included.
  84. ncbi Sing the mind electric - principles of deep brain stimulation
    Morten L Kringelbach
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 32:1070-9. 2010
    ..At the same time, it is important to proceed with caution and not repeat the errors from the era of psychosurgery.
  85. ncbi Anterior motor strip displacement in a boy with right frontal gray matter heterotopia undergoing epilepsy surgery
    Andrew S Little
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    Epilepsy Behav 11:241-6. 2007
    ..In addition, he is one of the few reported cases of focal cortical dysplasia resection with resultant improved behavior. These observations of unusual cortical representations have implications in epilepsy surgery planning...
  86. ncbi Gottlieb Burckhardt and Egas Moniz--two beginnings of psychosurgery
    Zbigniew Kotowicz
    Department of History, Goldsmiths College, University of London, New Cross, UK
    Gesnerus 62:77-101. 2005
    This article compares the repercussions of the two attempts at psychosurgery, the first in 1888 by the Swiss psychiatrist Gottlieb Burckhardt and the second by the Portuguese neurologist Egas Moniz...
  87. ncbi Comparability of the expanded WMS-III standardization protocol to the published WMS-III among right and left temporal lobectomy patients
    R C Doss
    Section of Neuropsychology, Cleveland Clinic Foundation, OH, USA
    Clin Neuropsychol 14:468-73. 2000
    ..The current study indicates that temporal lobectomy patients obtained comparable scores on the two versions of the WMS-III...
  88. ncbi Stereotactic lesions for the treatment of psychiatric disorders
    James W Leiphart
    Department of Neurological Surgery, The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
    J Neurosurg 113:1204-11. 2010
    ....
  89. ncbi [Rasnmussen syndrome. 7 years' follow-up. Aspects related to cerebral plasticity in epilepsy]
    Francisco Aguilar Rebolledo
    Universidad Nacional Autonoma de Mexico
    Rev Invest Clin 54:209-17. 2002
    ..This patient is a good example of neuronal plasticity in epilepsy surgery...
  90. ncbi Stereotactic neurosurgical treatment of drug addiction
    Lin Lu
    National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Beijing 100083, China
    Am J Drug Alcohol Abuse 35:391-3. 2009
    ..Stereotactic neurosurgery is a well-developed and accepted treatment for movement disorders like Parkinson's disease...
  91. ncbi Chapter 35: the frontal lobes
    Christopher M Filley
    Behavioral Neurology Section, Departments of Neurology and Psychiatry, University of Colorado Denver School of Medicine and Denver Veterans Medical Center, Denver, CO 80045, USA
    Handb Clin Neurol 95:557-70. 2010
    ..In the 20th century, progress came with Luria's observations of frontal lobe injuries and from the psychosurgery era, followed by contributions of behavioral neurology, neuroimaging, and neuroanatomy, which helped delineate ..
  92. pmc Pediatric facial burns: Is facial transplantation the new reconstructive psychosurgery?
    Mark D Hanson
    The Hospital for Sick Children, Toronto, Ontario
    Can J Plast Surg 16:205-10. 2008
    ..The present paper addresses the question "Could facial transplantation be of therapeutic benefit in the treatment of pediatric burns associated with facial disfigurement?"..
  93. ncbi Surgery of the mind and mood: a mosaic of issues in time and evolution
    A Chris Heller
    Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Neurosurgery 59:720-33; discussion 733-9. 2006
    ..Eventual coupling of cellular and molecular biology and nanotechnology with surgical enterprise is on the horizon...
  94. ncbi Differentiating between benign and less benign: epilepsy surgery in symptomatic frontal lobe epilepsy associated with benign focal epileptiform discharges of childhood
    Dirk Matthias Altenmüller
    Epilepsy Center, University of Freiburg, Freiburg, Germany
    J Child Neurol 22:456-61. 2007
    ..In symptomatic frontal lobe epilepsy, epilepsy surgery may yield an excellent outcome despite the presence of concurrent benign focal epileptiform discharges of childhood...
  95. ncbi Quality of life after surgery for temporal lobe epilepsy: a 5-year follow-up
    Inês Cunha
    Centro Hospitalar Psiquiátrico de Lisboa and Centro Hospitalar Lisboa Ocidental Egas Moniz Hospital, Lisbon, Portugal
    Epilepsy Behav 17:506-10. 2010
    ..Engels class I patients demonstrated statistically better results in the fourth and fifth years of follow-up. Neither years of disease nor patient age at surgery seemed to influence QOL...
  96. ncbi Psychosurgery: the past and present of ablation procedures
    Marek Harat
    Department of Neurosurgery and Head Surgery, 10th Military Clinical Hospital, Bydgoszcz, Poland
    Neuro Endocrinol Lett 29:105-22. 2008
    Surgical intervention to the brain has a long history, but contemporary psychosurgery started in the mid-1930s. The first psychosurgical operation was a prefrontal leucotomy...
  97. pmc Lesion analysis for cingulotomy and limbic leucotomy: comparison and correlation with clinical outcomes
    Jimmy C Yang
    Departments of Neurosurgery
    J Neurosurg 120:152-63. 2014
    ....
  98. pmc Correlation of quantitative MRI and neuropathology in epilepsy surgical resection specimens--T2 correlates with neuronal tissue in gray matter
    S H Eriksson
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, Box 29, London WC1N 3BG, UK
    Neuroimage 37:48-55. 2007
    ..This will enable better identification and delineation of the structural causes of refractory focal epilepsy, and will be of particular benefit in patients in whom current optimal MRI does not identify a relevant abnormality...
  99. ncbi Stereotactic neurosurgical treatment of addiction: minimizing the chances of another 'great and desperate cure'
    Wayne Hall
    Addiction 101:1-3. 2006
  100. ncbi [Surgical treatment of patients with therapy-resistant obsessive-compulsive disorder. Review]
    Katalin Csigo
    Nyiro Gyula Korhaz, II Pszichiátria
    Psychiatr Hung 23:94-108. 2008
    ..Two techniques, namely anterior capsulotomy and deep brain stimulation will be discussed in greater detail. Finally, we review the results of neuropsychological and personality changes associated with anterior capsulotomy...
  101. ncbi The painless brain: lobotomy, psychiatry, and the treatment of chronic pain and terminal illness
    Mical Raz
    TheVan Leer Institute, Jabotinsky 43, Jerusalem, Israel
    Perspect Biol Med 52:555-65. 2009
    ..What normalizing social function does the use of psychiatric interventions in pain treatment fulfill? This approach leads to a reexamination of perceptions of dualism in pain medicine...

Research Grants8

  1. PHYSIOLOGIC STUDIES OF ANGER IN DEPRESSED PATIENTS
    Darin Dougherty; Fiscal Year: 2002
    ..abstract_text> ..
  2. BRAIN ACTIVATION PROFILES IN DYSLEXIA--A MEG STUDY
    Andrew Papanicolaou; Fiscal Year: 2003
    ..abstract_text> ..
  3. CONTRIBUTIONS OF MEG TO THE SURGICAL MGMT OF EPILEPSY
    Andrew Papanicolaou; Fiscal Year: 2003
    ....
  4. Integration of MSI/fMRI Studies of Reading
    Andrew Papanicolaou; Fiscal Year: 2004
    ..Together these efforts will expand the interpretability of imaging data by direct comparison and integration of the techniques and lead to a more elaborated theory of the cerebral mechanisms underlying reading. ..
  5. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  6. DISORDERS OF NEURONAL MIGRATION AND EPILEPSY
    STEVEN ROPER; Fiscal Year: 2005
    ..These experiments will advance our understanding of cortical dysplasia and epilepsy and give greater insight the mechanisms that produce long-term impairment of inhibition after an isolated in utero injury. ..
  7. Semantic Memory and MRI Volumetrics in Epilepsy
    Brian Bell; Fiscal Year: 2005
    ..abstract_text> ..
  8. Improving Learning in MS: A Randomized Clinical Trial
    Nancy Chiaravalloti; Fiscal Year: 2008
    ..In addition, we will be able to draw conclusions regarding the impact of this particular memory remediation program on everyday life from questionnaires completed by the participant and a significant other. [unreadable] [unreadable]..