chemical sympathectomy

Summary

Summary: Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.

Top Publications

  1. ncbi Modulation of visceral nociceptive responses of rat spinal dorsal horn neurons by sympathectomy
    J Kalmari
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Neuroreport 12:797-801. 2001
  2. ncbi Chemical sympathectomy alters food intake and thermogenic responses to catecholamines in rats
    Ivan Villanueva
    Departamento de Fisiologia, Escuela Nacional de Ciencias Biologicas, I P N México, 11340 Col Casco de Sto Tomás, Mexico
    Life Sci 71:789-801. 2002
  3. ncbi Rat heart GDNF: effect of chemical sympathectomy
    Patricia M Martinelli
    Department of Morphology, Institute of Biological Sciences ICB, Federal University of Minas Gerais UFMG, 31270 901 Belo Horizonte, MG, Brazil
    Histochem Cell Biol 118:337-43. 2002
  4. ncbi Positron emission imaging of cardiac sympathetic innervation and function using 18F-6-fluorodopamine: effects of chemical sympathectomy by 6-hydroxydopamine
    D S Goldstein
    Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892
    J Hypertens 9:417-23. 1991
  5. ncbi Preservation of the baroreceptor heart rate reflex by chemical sympathectomy in experimental heart failure
    Luca Mircoli
    Divisione di Cardiologia, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    Circulation 106:866-72. 2002
  6. ncbi Chemical sympathectomy inhibits periodontal disease in Fischer 344 rats
    Torbjørn Breivik
    Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    J Periodontal Res 40:325-30. 2005
  7. ncbi Sympathetic neural modulation of the immune system. I. Depression of T cell immunity in vivo and vitro following chemical sympathectomy
    K S Madden
    Department of Microbiology, University of Rochester Medical Center, New York 14642
    Brain Behav Immun 3:72-89. 1989
  8. ncbi The effects of chemical sympathectomy on testicular injury in varicocele
    H Ozturk
    Department of Paediatric Surgery, and Animal Research Center, Gulhane Military Medical Academy, Ankara, Turkey
    BJU Int 87:232-4. 2001
  9. ncbi Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion
    Robert L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Am J Physiol Endocrinol Metab 284:E778-87. 2003
  10. ncbi Chemical sympathectomy for neuropathic pain: does it work? Case report and systematic literature review
    A D Furlan
    Comprehensive Pain Program, The Toronto Western Hospital, and Institute for Work and Health, Ontario, Canada
    Clin J Pain 17:327-36. 2001

Research Grants

Detail Information

Publications205 found, 100 shown here

  1. ncbi Modulation of visceral nociceptive responses of rat spinal dorsal horn neurons by sympathectomy
    J Kalmari
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Neuroreport 12:797-801. 2001
    ....
  2. ncbi Chemical sympathectomy alters food intake and thermogenic responses to catecholamines in rats
    Ivan Villanueva
    Departamento de Fisiologia, Escuela Nacional de Ciencias Biologicas, I P N México, 11340 Col Casco de Sto Tomás, Mexico
    Life Sci 71:789-801. 2002
    ..Compared with controls, Gnt-treated rats also showed a limited thermogenic capacity not related to feeding, and a greater degree of carbohydrate oxidation, possibly due to a defect in E-induced lipolysis, which is beta-adrenergic...
  3. ncbi Rat heart GDNF: effect of chemical sympathectomy
    Patricia M Martinelli
    Department of Morphology, Institute of Biological Sciences ICB, Federal University of Minas Gerais UFMG, 31270 901 Belo Horizonte, MG, Brazil
    Histochem Cell Biol 118:337-43. 2002
    ..In this work, chemical sympathectomy by 6-hydroxydopamine provided the model for assessing heart GDNF expression during denervation and axonal ..
  4. ncbi Positron emission imaging of cardiac sympathetic innervation and function using 18F-6-fluorodopamine: effects of chemical sympathectomy by 6-hydroxydopamine
    D S Goldstein
    Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892
    J Hypertens 9:417-23. 1991
    ..PET) scanning after systemic intravenous injection of 18F-6-fluorodopamine, and the effects of chemical sympathectomy by the neurotoxin, 6-hydroxydopamine (6-OHDA)...
  5. ncbi Preservation of the baroreceptor heart rate reflex by chemical sympathectomy in experimental heart failure
    Luca Mircoli
    Divisione di Cardiologia, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    Circulation 106:866-72. 2002
    ..The purpose of the present study was to test the hypothesis that this alteration depends on the marked degree of sympathetic overactivity known to characterize the CHF syndrome...
  6. ncbi Chemical sympathectomy inhibits periodontal disease in Fischer 344 rats
    Torbjørn Breivik
    Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    J Periodontal Res 40:325-30. 2005
    ....
  7. ncbi Sympathetic neural modulation of the immune system. I. Depression of T cell immunity in vivo and vitro following chemical sympathectomy
    K S Madden
    Department of Microbiology, University of Rochester Medical Center, New York 14642
    Brain Behav Immun 3:72-89. 1989
    b>Chemical sympathectomy of adult mice with 6-hydroxydopamine (6-OHDA) either prior to or following epicutaneous sensitization with the trinitrophenyl (TNP) hapten decreased the delayed hypersensitivity (DH) response to ear challenge...
  8. ncbi The effects of chemical sympathectomy on testicular injury in varicocele
    H Ozturk
    Department of Paediatric Surgery, and Animal Research Center, Gulhane Military Medical Academy, Ankara, Turkey
    BJU Int 87:232-4. 2001
    ..To determine whether the sympathetic nervous system plays a role in the contralateral testicular deterioration encountered in varicocele...
  9. ncbi Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion
    Robert L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Am J Physiol Endocrinol Metab 284:E778-87. 2003
    ..After neonatal chemical sympathectomy, changes in weight and food intake were compared in groups of sympathectomized (SYM) and control (CON) ..
  10. ncbi Chemical sympathectomy for neuropathic pain: does it work? Case report and systematic literature review
    A D Furlan
    Comprehensive Pain Program, The Toronto Western Hospital, and Institute for Work and Health, Ontario, Canada
    Clin J Pain 17:327-36. 2001
    To determine if chemical sympathectomy successfully reduces limb neuropathic pain.
  11. ncbi The influence of chemical sympathectomy on pain responsivity and alpha 2-adrenergic antinociception in neuropathic animals
    H Wei
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Neuroscience 114:655-68. 2002
    We studied the effect of chemical sympathectomy by 6-hydroxydopamine (6-OHDA) on pain behavior and alpha(2)-adrenergic antinociception in rats with a spinal nerve ligation-induced neuropathy...
  12. ncbi Chemical sympathectomy-induced changes in TH-, VIP-, and CGRP-immunoreactive fibers in the rat mandible periosteum: influence on bone resorption
    M Cherruau
    Laboratoire de Biologie et Physiopathologie Cranio faciales, Faculte de Chirurgie Dentaire, Universite Rene Descartes Paris 5, Arnoux Montrouge, France
    J Cell Physiol 194:341-8. 2003
    ..Nevertheless, these fibers did not originate from the SCG, contrary to TH-IR fibers...
  13. ncbi Monoamine oxidase (MAO) in pancreatic islets of the mouse: some characteristics and the effect of chemical sympathectomy
    A Stenstrom
    Department of Pharmacology University of Umea, Sweden
    Diabetes Res 11:81-4. 1989
    We have previously observed that chemical sympathectomy in the guinea pig induced an increase in the intensity of serotonin fluorescence in the insulin cells of the pancreatic islets...
  14. ncbi Pulmonary vascular responses to surgical chemodenervation and chemical sympathectomy in dogs
    R Naeije
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    J Appl Physiol (1985) 66:42-50. 1989
    We investigated the effects of surgical peripheral chemoreceptor denervation, chemical sympathectomy with 6-hydroxydopamine (6-OHDA), and the peripheral chemoreceptor stimulant almitrine on multipoint pulmonary arterial pressure-cardiac ..
  15. ncbi Capsaicin-induced corneal lesions in mice and the effects of chemical sympathectomy
    T Shimizu
    Department of Pharmacology, Faculty of Medicine, Kagoshima University, Japan
    J Pharmacol Exp Ther 243:690-5. 1987
    Effects of chemical sympathectomy on corneal changes induced in mice by a s.c. injection of capsaicin were investigated. Pretreatment with a s.c...
  16. ncbi Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesions
    G M Pasinetti
    Department of Psychiatry, Mt Sinai School of Medicine, New York, New York 10029 6574, USA
    Synapse 31:278-84. 1999
    ..We conclude that aging changes in striatal GFAP mRNAs do not interact with loss of dopaminergic output to the striatum from 6-OHDA lesions and may be independent of the relatively modest dopaminergic losses during normal aging...
  17. ncbi Firing regulation in dopaminergic cells: effect of the partial degeneration of nigrostriatal system in surviving neurons
    Manuel Rodriguez
    Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain
    Eur J Neurosci 18:53-60. 2003
    ..Under these conditions, small fluctuations in firing rate are not compensated for in time, which could be one of the factors responsible for the motor fluctuations often observed in advanced Parkinson's disease...
  18. ncbi In vivo stimulation of sympathetic nervous system modulates osteoblastic activity in mouse calvaria
    Ayami Kondo
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
    Am J Physiol Endocrinol Metab 285:E661-7. 2003
    ..These results indicate that in vivo adrenergic stimulation modulates the osteoblastic activity in mouse calvaria via noradrenergic nerve terminals...
  19. ncbi High frequency stimulation of the subthalamic nucleus improves treadmill locomotion in unilateral 6-hydroxydopamine lesioned rats
    Jing Yu Chang
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 983:174-84. 2003
    ..This work may provide a rodent model for deep brain stimulation (DBS) in patients with Parkinson's disease, and be suitable for further investigation of the neural mechanisms underlying the therapeutic effects of DBS...
  20. ncbi Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers
    Linda S Sorkin
    Department of Anesthesiology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Exp Neurol 184:162-8. 2003
    ..Information on pain and inflammation in the periphery is transmitted to the nervous system, where increased spinal adenosine levels can suppress peripheral inflammation...
  21. ncbi Interaction between serotonergic and noradrenergic axons during axonal regeneration
    Ying Liu
    Department of Neuroscience, Yamaguchi University School of Medicine, 755 8505, Ube, Yamaguchi, Japan
    Exp Neurol 184:169-78. 2003
    ..The differential roles of 5-HT and NA axons in axonal regeneration may play a role in a variety of physiological functions related to these monoamines and possibly in the pathophysiology of clinical depression...
  22. ncbi Cholecystokinin-8 promotes recovery of sympathectomy induced by 6-hydroxydopamine in adult mice
    L Manni
    Institute of Neurobiology (CNR, Rome, Italy
    Neuroreport 12:1621-7. 2001
    ..This latter observation suggests that the effect of CCK-8 might be mediated through the stimulation of NGF synthesis...
  23. ncbi Upregulation of striatal adenosine A2A receptor mRNA in 6-hydroxydopamine-lesioned rats intermittently treated with L-DOPA
    Masahiko Tomiyama
    Third Department of Medicine, Hirosaki University School of Medicine, Hirosaki 036 8216, Japan
    Synapse 52:218-22. 2004
    ..These results suggest that A2A receptor activation is associated with the development of motor complications induced by L-DOPA treatment...
  24. ncbi Chemical sympathectomy increases numbers of inflammatory cells in the peritoneum early in murine listeriosis
    P A Rice
    Department of Pulmonary and Critical Care Medicine, University of Maryland, 3C116, VAMC 10 N Greene Street, Baltimore, MD 21201, USA
    Brain Behav Immun 16:654-62. 2002
    ..This suggests that sympathectomy-induced decreases systemic bacterial loads are associated with increased recruitment of inflammatory cells into tissues during the innate immune response...
  25. ncbi Behaviorally conditioned immunosuppression in the rat is regulated via noradrenaline and beta-adrenoceptors
    Michael S Exton
    Department of Medical Psychology, University of Essen, Hufelandstr 55, 45122, Essen, Germany
    J Neuroimmunol 131:21-30. 2002
    ..b>Chemical sympathectomy via 6-OHDA completely blocked the conditioned suppression of splenocyte proliferation to mitogens and ..
  26. ncbi Chemical sympathectomy alters numbers of splenic and peritoneal leukocytes
    P A Rice
    Department of Environmental Medicine, University of Rochester School of Medicine, New York 14642, USA
    Brain Behav Immun 16:62-73. 2002
    ..Sympathectomy did not affect tumor necrosis factor-alpha, interleukin-12, or interferon-gamma production in cultured splenocytes or PEC in either infected or uninfected mice...
  27. ncbi Stereoselective effects of methylphenidate on motor hyperactivity in juvenile rats induced by neonatal 6-hydroxydopamine lesioning
    Eugen Davids
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 160:92-8. 2002
    ..The enantiomers of methylphenidate differ markedly in stimulant potency but have not been compared in the 6-OHDA lesion model...
  28. ncbi 6-Hydroxydopamine-lesioning of the nigrostriatal pathway in rats alters basal ganglia mRNA for copper, zinc- and manganese-superoxide dismutase, but not glutathione peroxidase
    G Kunikowska
    Neurodegenerative Diseases Research Centre, Division of Pharmacology and Therapeutics, Guy's, King's and St Thomas' School of Biomedical Sciences, Hodgkin Building, King's College, London SE1 1UL, UK
    Brain Res 922:51-64. 2001
    ..These findings may clarify the status of antioxidant enzymes, particularly Mn-SOD, in patients with Parkinson's disease and their relevance to disease pathogenesis...
  29. ncbi [Effect of chemical sympathectomy on myoelectric activity of the small bowel]
    B Koprowska
    Katedra Patofizjologii Collegium Medicum UJ ul. Czysta 18,
    Folia Med Cracov 42:75-81. 2001
    ..CONCLUSION: Peripheral noradrenergic system has a significant effect on the frequency and variability of slow wave and minor role on its amplitude but no on diarrhoea pattern...
  30. ncbi Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats
    Qi Mei
    Division of Endocrinology and Metabolism, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes 51:2997-3002. 2002
    ..Because eSIN occurs selectively in the islet, is rapid in onset, and is associated with autoimmune but not chemically induced diabetes, it is distinct from DAN in location, time course, and mechanism...
  31. ncbi Sympathetic nervous system plays a major role in acute cold/restraint stress inhibition of host resistance to Listeria monocytogenes
    Ling Cao
    Wadsworth Center, New York State Department of Health, Empire State Plaza, P O Box 509, Albany, NY 12201 0509, USA
    J Neuroimmunol 125:94-102. 2002
    ..of CORT and NE was investigated by pretreating mice with the CORT synthesis inhibitor metyrapone and the chemical sympathectomy drug 6-hydroxydopamine (6-OHDA), respectively...
  32. ncbi Effects of infantile/prepubertal chronic estrogen treatment and chemical sympathectomy with guanethidine on developing cholinergic nerves of the rat uterus
    Analía Richeri
    Laboratorio de Biologia Celular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    J Histochem Cytochem 50:839-50. 2002
    ..in this study we analyzed the effects of infantile/prepubertal chronic estrogen treatment, chronic chemical sympathectomy with guanethidine, and combined sympathectomy and chronic estrogen treatment on developing cholinergic ..
  33. ncbi Evaluation of the mGluR2/3 agonist LY379268 in rodent models of Parkinson's disease
    Tracey K Murray
    Lilly Research Centre, Eli Lilly and Co Ltd, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK
    Pharmacol Biochem Behav 73:455-66. 2002
    ..These data suggest that activation of Group II mGlu receptors can provide some protection in models of PD, while their role in providing functional improvement is less clear...
  34. ncbi A comparison of two behavioral measures of psychomotor activation following intravenous amphetamine or cocaine: dose- and sensitization-dependent changes
    H S Crombag
    Department of Psychology, The University of Michigan, Ann Arbor 48109 1109, USA
    Behav Pharmacol 10:205-13. 1999
    ..The data highlight the advantages and disadvantages of these measures as indices of the psychomotor activating effects of psychostimulant drugs...
  35. ncbi Fixed ratio discrimination training increases in vivo striatal dopamine in neonatal 6-OHDA-lesioned rats
    Pippa S Loupe
    Schiefelbusch Institute for Life Span Studies, 1052 Dole Human Development Center, University of Kansas, Lawrence, KS 66045, USA
    Pharmacol Biochem Behav 74:61-71. 2002
    ....
  36. ncbi Locomotor stimulant effects of nornicotine: role of dopamine
    T A Green
    Department of Psychology, University of Kentucky, Lexington, KY 40506 0044, USA
    Pharmacol Biochem Behav 74:87-94. 2002
    ....
  37. ncbi Effects of chemical sympathectomy by means of 6-hydroxydopamine on insulin secretion and islet morphology in alloxan-diabetic mice
    Martina Kvist-Reimer
    Department of Medicine, Lund University, B11 BMC, 221 84 Lund, Sweden
    Cell Tissue Res 307:203-9. 2002
    ..In this study, we tested whether elimination of sympathetic nerve activity by chemical sympathectomy with 6-hydroxydopamine (6-OHDA; 60 mg/kg) ameliorates the diabetogenic effects of alloxan (50 mg/kg) in ..
  38. ncbi PNU-96391A (OSU6162) antagonizes the development of behavioral sensitization induced by dopamine agonists in a rat model for Parkinson's disease
    N F Nichols
    Neurobiology Research, Pharmacia Corporation, Kalamazoo, MI 49001, USA
    Neuropharmacology 43:817-24. 2002
    ..These results suggest that PNU-96391A could be therapeutically useful to prevent the development of behavioral sensitization induced by DA agonists...
  39. ncbi Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleus
    Nasser Haddjeri
    Laboratory of Neuropharmacology and Neurochemistry INSERM U512, University Claude Bernard, Avenue Rockfeller, Lyon, France
    Neuropsychopharmacology 29:1800-6. 2004
    ..When the fluctuations of the function of NE neurons normally produced by WAY 100,635 were prevented, a tonic activation of 5-HT(1A) autoreceptors by endogenous 5-HT was unmasked...
  40. ncbi Age and gender differences in behavioral and morphological outcome after 6-hydroxydopamine-induced lesion of the substantia nigra in rats
    Andrea Tamas
    Department of Anatomy, Neurohumoral Regulations Research Group of the Hungarian Academy of Sciences, University Medical Faculty, Szigeti u 12, 7624 Pecs, Hungary
    Behav Brain Res 158:221-9. 2005
    ..In summary, our present results showed clear age- and gender differences in the behavioral and histological outcome following 6-OHDA lesion of the substantia nigra...
  41. pmc Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration
    A H Rezvani
    Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Neuroscience 154:885-97. 2008
    ..These results show that interfering with normal dopamine innervation of the frontal cortex during early postnatal development has persisting behavioral effects, which are sex-specific...
  42. ncbi Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb
    Beate Winner
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Exp Neurol 197:113-21. 2006
    ..This study supports the accumulating evidence that neurotransmitters play a crucial role in determining survival and differentiation of newly generated neurons...
  43. ncbi Subchronic intermittent caffeine administration to unilaterally 6-hydroxydopamine-lesioned rats sensitizes turning behaviour in response to dopamine D(1) but not D(2) receptor agonists
    Omar Cauli
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Behav Pharmacol 16:621-6. 2005
    ..The results show that repeated intermittent caffeine exposure enhances the motor stimulant effects elicited by dopamine agonists by a preferential sensitization of dopamine D(1) receptors...
  44. ncbi Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex
    S M Clinton
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Psychopharmacology (Berl) 183:404-12. 2006
    ....
  45. ncbi A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area
    Léder Leal Xavier
    Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Rua Ipiranga 6681, CEP 90619 900, Porto Alegre, RS, Brazil
    Brain Res Brain Res Protoc 16:58-64. 2005
    ..We believe that this protocol will facilitate the evaluation of mesencephalic TH immunoreactivity in various available animal models of Parkinson's disease...
  46. ncbi Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's disease
    Nicholas M Kanaan
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Brain Res 1068:221-9. 2006
    ..As direct neurotrophic effects of Epo were not observed in vitro, the mechanism of Epo neuroprotection remains to be elucidated...
  47. ncbi L-DOPA inhibits depolarization-induced [3H]GABA release in the dopamine-denervated globus pallidus of the rat: the effect is dopamine independent and mediated by D2-like receptors
    I Silva
    Departamento de Fisiologia, Biofísica y Neurociencias del CINVESTAV, Mexico, Mexico
    J Neural Transm 113:1847-53. 2006
    ..L-DOPA could control Parkinson's disease symptoms acting not only as dopamine precursor but also by itself...
  48. ncbi Changes in dopamine D2 receptors and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine uptake in the brain of 6-hydroxydopamine-lesioned rats
    Yasushi Ishida
    Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Neurodegener Dis 1:109-12. 2004
    ..Therefore, the combination of a D2 antagonist and FDOPA may provide a potentially useful method for assessing the effects of dopamine depletion in Parkinson's disease...
  49. pmc Nicotine's attenuation of body weight involves the perifornical hypothalamus
    Phillip R Kramer
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, 3302 Gaston Ave Dallas, TX 75246, USA
    Life Sci 81:500-8. 2007
    ..These results are consistent with NIC reducing food intake in part by acting through catecholaminergic neurons within or extending through the PFH...
  50. ncbi Requirement of intact sympathetic transmission for the ocular hypotensive effects of melatonin and 5-MCA-NAT
    Pilar Alarma-Estrany
    Departamento de Bioquimica, Universidad Complutense de Madrid, 28037 Madrid, Spain
    Auton Neurosci 137:63-6. 2007
    ..After chemical sympathectomy by reserpine or 6-hydroxydopamine, the hypotensive effects of melatonin and 5-MCA-NAT are severely ..
  51. ncbi Locus coeruleus noradrenergic neurons and CO2 drive to breathing
    Vivian Biancardi
    Department of Animal Morphology and Physiology, Sao Paulo State University UNESP FCAV, Jaboticabal, SP, Brazil
    Pflugers Arch 455:1119-28. 2008
    ..Thus, we conclude that LC noradrenergic neurons modulate hypercapnic ventilatory response but play no role in cardiovascular and thermal regulation under resting conditions...
  52. ncbi [Behavioral evaluation of the unilateral lesion model in rats using 6-hydroxydopamine. Correlation between the rotations induced by D-amphetamine, apomorphine and the manual dexterity test]
    N Pavon
    Centro Internacional de Restauracion Neurologica, CIREN, La Habana, Cuba
    Rev Neurol 26:915-8. 1998
    ....
  53. ncbi Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation
    S Li
    Biology Department, Emory University, Atlanta, GA 30322, USA
    J Neurophysiol 98:3525-37. 2007
    ..Thus antidromic resonant activation of cortical microcircuits may make an important contribution toward counteracting the overly synchronous and oscillatory activity characteristic of cortical activity in PD...
  54. ncbi Sympathetic pharmacological denervation in ageing rats: effects on ovulatory response and follicular population
    Rebeca Chávez-Genaro
    Histology and Embryology Department, School of Medicine, General Flores 2125, CP 11800, Montevideo, Uruguay
    Reprod Fertil Dev 19:954-60. 2007
    ..The action of ovarian noradrenergic innervation seems to be associated with folliculogenesis and the ovarian response to gonadotrophins...
  55. pmc Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6
    N Yamamoto
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Room L1004, Boston, MA 02118, USA
    Neuroscience 154:1088-99. 2008
    ..They also suggest that the down-regulation of nigral GABA(A) receptors is linked to the increase in striatal GAD67 mRNA levels in the dopamine-depleted striatum...
  56. ncbi Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson's disease
    T P Harrower
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Exp Neurol 197:56-69. 2006
    ..This demonstrates that such xenografted cells may be able to recreate the damaged circuitry in PD although strategies for dopaminergic differentiation of the porcine neural precursor cell remain to be refined...
  57. ncbi Ultra violet-induced localized inflammatory hyperalgesia in awake rats and the role of sensory and sympathetic innervation of the skin
    Nayef E Saade
    Department of Human Morphology, Faculty of Medicine, American University of Beirut, Riad E1 Solh Beirut, Beirut 1107 2020, Lebanon
    Brain Behav Immun 22:245-56. 2008
    ....
  58. ncbi Receptor binding occurrence and plasma levels of natriuretic peptides in response to sympathectomy
    Magnus Hansson
    Department of Integrative Medical Biology, Section for Anatomy, and Department of Medical Biosciences, Section for Pathology, Umea University, SE 901 87 Umea, Sweden
    Microsc Res Tech 67:90-9. 2005
    ..In order to destruct the cardiac sympathetic nerve terminals, chemical sympathectomy with 6-hydroxydopamine was made in parallel with intravenous measurements of blood pressure and heart ..
  59. ncbi Serotonin 5-HT2A but not 5-HT2C receptor antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the D1 agonist SKF 82958
    Christopher Bishop
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield, Detroit, MI 48201, USA
    Neuropharmacology 49:350-8. 2005
    ..These results indicate that DA depletion strengthens striatal 5-HT2A/D1 receptor interactions and suggest that 5-HT2A receptor antagonists may prove useful in reducing D1-related movements...
  60. ncbi Stress reduces the neuroprotective effect of exercise in a rat model for Parkinson's disease
    Fleur M Howells
    Division of Physiology, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Room 5 02, Anatomy Building, South Africa
    Behav Brain Res 165:210-20. 2005
    ..The behavioural results confirm a previous finding suggesting that voluntary exercise is neuroprotective. A novel finding is that mild stressors cancel the neuroprotection afforded by voluntary exercise...
  61. ncbi Sympathetic denervation does not prevent a reduction in fat pad size of rats or mice treated with peripherally administered leptin
    Cherie R Rooks
    Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30602, USA
    Am J Physiol Regul Integr Comp Physiol 289:R92-102. 2005
    ..These changes in intact pads of rats with one denervated fat pad imply communication between fat depots and suggest that both leptin and the SNS regulate the size of individual depots...
  62. ncbi The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959
    Xuechu Zhen
    Department of Physiology Pharmacology, City University of New York Medical School, 138th Street and Convent Ave New York, NY 10031, USA
    Pharmacol Biochem Behav 80:597-601. 2005
    ....
  63. ncbi Dissociation of hemi-spatial and hemi-motor impairments in a unilateral primate model of Parkinson's disease
    A L Milton
    Department of Experimental Psychology, Downing Street, Cambridge CB3 2EB, UK
    Behav Brain Res 150:55-63. 2004
    ..Patients with bilateral Parkinson's symptoms may exhibit bilateral deficits in mental representation...
  64. ncbi Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and alpha6 and beta3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat
    N P Visanji
    King s College London, Wolfson Centre for Age Related Diseases, Wolfson Wing, Hodgkin Building, UK
    Neuropharmacology 50:36-46. 2006
    ....
  65. ncbi Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism
    A Lopez-Real
    Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Neurosci Res 81:865-73. 2005
    ..Our results suggest that angiotensin-converting enzyme inhibitors may be useful for treatment of Parkinson's disease and that further investigation should focus on the neuroprotective capacity of these compounds...
  66. ncbi alpha1-Adrenoceptors in proximal segments of tail arteries from control and reserpinised rats
    Susana Y Kamikihara
    Department of Pharmacology, Instituto de Biociencias, UNESP, Botucatu, SP 18618 000, Brazil
    Naunyn Schmiedebergs Arch Pharmacol 376:117-26. 2007
    ..recently shown that the supersensitivity of distal segments of the rat tail artery to phenylephrine after chemical sympathectomy with reserpine results from the appearance of alpha(1D)-adrenoceptors...
  67. ncbi Pronociceptive response elicited by TRPA1 receptor activation in mice
    E L Andrade
    Department of Pharmacology, Federal University of Santa Catarina, CCB, Campus Universitario Trindade, 88049 900, Florianopolis, SC, Brazil
    Neuroscience 152:511-20. 2008
    ..Moreover, capsaicin and allyl isothiocyanate-induced nociception were not significantly changed by chemical sympathectomy produced by guanethidine...
  68. ncbi Role of sympathetic nervous system in experimental hypertension and diabetes mellitus
    C L Kaul
    National Institute of Pharmaceutical Education and Research, S A S Nagar Mohali, Punjab, India
    Clin Exp Hypertens 21:95-112. 1999
    ..b>Chemical sympathectomy with 6-OHDA did not show any glucose intolerance in rhesus monkeys or any effect or insulin release...
  69. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
    ..4. Chemical sympathectomy by chronically administered 6-hydroxydopamine (6-OHDA) did not inhibit bradykinin-induced plasma ..
  70. ncbi Increased dopamine-beta-hydroxylase-like immunoreactivity in non-noradrenergic axons supplying the guinea-pig uterine artery after 6-hydroxydopamine treatment
    J L Morris
    Department of Anatomy and Histology, Flinders University of South Australia, Bedford Park
    J Auton Nerv Syst 21:15-27. 1987
    ..After chemical sympathectomy with 6-OHDA, the levels of DBH immunoreactivity in axons of non-noradrenergic neurons increased, and more ..
  71. ncbi Effect of 6-hydroxydopamine on gluconeogenesis in the rat renal cortex
    C Cojocel
    Faculty of Medicine, Department of Pharmacology and Toxicology, Kuwait University, Safat, Kuwait
    Clin Exp Pharmacol Physiol 30:55-9. 2003
    ..2. 6-Hydroxydopamine is used for chemical sympathectomy because it selectively destroys adrenergic nerve endings...
  72. pmc Peripheral, but not central nervous system, type I interferon expression in mice in response to intranasal vesicular stomatitis virus infection
    Mark D Trottier
    Biology Department, New York University, New York, NY 10003, USA
    J Neurovirol 13:433-45. 2007
    ..Experiments with chemical sympathectomy, sRAGE, and neutralizing antibody to VSV were performed to investigate the mechanism(s) utilized for ..
  73. ncbi Role of sympathoadrenomedullary system in cardiovascular response to stress in rats
    B A Barron
    Department of Medicine, University of Kentucky, Lexington
    J Auton Nerv Syst 28:179-87. 1989
    ..responses were investigated by factoring out their influence using adrenal demedullation (DMED) and/or chemical sympathectomy with guanethidine (GUAN)...
  74. ncbi Imidazoline receptor mediated natriuresis: central and/or peripheral effect?
    D D Smyth
    Department of Pharmacology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Auton Nerv Syst 72:155-62. 1998
    ..Finally, chemical sympathectomy with reserpine did not alter the response to intrarenal moxonidine suggesting that this effect was ..
  75. ncbi Sympathetic nervous system mediates central corticotropin-releasing factor induced suppression of natural killer cytotoxicity
    M Irwin
    Department of Psychiatry, San Diego Veterans Administration Medical Center, California
    J Pharmacol Exp Ther 255:101-7. 1990
    ..Pretreatment of the animals by chemical sympathectomy (6-hydroxy-dopamine, 100 mg/kg i.p...
  76. ncbi Sympathetic histamine exerts different pre- and post-synaptic functions according to the frequencies of nerve stimulation in guinea pig vas deferens
    Gonghao He
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an, China
    J Neurochem 106:1710-9. 2008
    ..and mast cell stabilizer cromolyn, but was highly sensitive to Na(+) channel blocker tetrodotoxin and chemical sympathectomy with 6-hydroxydopamine. The neurogenically released HA evoked by 12...
  77. ncbi Effect of pre-existing inflammation on carrageenan-induced paw oedema in rats
    S K Bhattacharya
    Department of Pharmacology, Banaras Hindu University, Varanasi, India
    J Pharm Pharmacol 39:854-6. 1987
    ..inflammatory response in the contralateral paw after 24 h was antagonized by bilateral adrenalectomy and chemical sympathectomy induced by 6-hydroxydopamine...
  78. ncbi Laparoscopic lumbar sympathectomy for lower-limb disease
    S Watarida
    Second Department of Surgery, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520 2192, Japan
    Surg Endosc 16:500-3. 2002
    ..b>Chemical sympathectomy has been introduced as a less invasive means of achieving sympatholysis; however, this method is also ..
  79. ncbi Occurrence of adrenergic nerve fibers and of noradrenaline in thymus gland of juvenile and aged rats
    C Cavallotti
    Department of Cardiovascular and Respiratory Sciences, University of Rome La Sapienza, Italy
    Immunol Lett 70:53-62. 1999
    ..After chemical sympathectomy with neurotoxin 6-OH dopamine, the greater part of ANF disappeared...
  80. ncbi Catecholamine depletion by reserpine blocks the anxiolytic actions of ethanol in the rat
    Christopher J LaBuda
    Department of Psychology, Box 19528, University of Texas at Arlington, Arlington, TX 76019, USA
    Alcohol 26:55-9. 2002
    ..The present study examined the effect of chemical sympathectomy by reserpine pretreatment on the subsequent anxiolytic action of ethanol...
  81. ncbi Activity-wheel running blunts suppression of splenic natural killer cell cytotoxicity after sympathectomy and footshock
    R K Dishman
    Department of Exercise Science, The University of Georgia, 30602 6554, Athens, GA, USA
    Physiol Behav 71:297-304. 2000
    We used chemical sympathectomy by 6-hydroxydopamine (6-OHDA) to examine whether adaptation by the sympathetic nervous system (SNS) is a plausible explanation for our prior finding that activity-wheel running blunts the suppression of ..
  82. ncbi Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice
    Bo Ahren
    Department of Medicine, Lund University, B11 Biomedical Centre, SE 221 84 Lund, Sweden
    Endocrinology 145:3190-6. 2004
    ..01). Similar effects were seen after chemical sympathectomy by 6-hydroxydopamine...
  83. ncbi Lack of beneficial effect of a tachykinin receptor antagonist in experimental colitis
    J L Wallace
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Alberta, Canada
    Regul Pept 73:95-101. 1998
    ..Studies in an experimental model of colitis have demonstrated that neuromodulation, through chemical sympathectomy or administration of lidocaine, can markedly attenuate granulocyte infiltration and tissue injury...
  84. ncbi Sympathectomy-induced immune changes are not abrogated by the glucocorticoid receptor blocker RU-486
    B Kruszewska
    Center for Psychoneuroimmunology Research, University of Rochester Medical Center, Rochester, New York, 14642, USA
    Brain Behav Immun 12:181-200. 1998
    ..This examines the possible role of glucocorticoids in these previously reported changes. In both strains, chemical sympathectomy triggers an elevation of glucocorticoid levels immediately following injection of 6-OHDA, returning to ..
  85. pmc Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain
    Marie Pertin
    Anesthesiology Pain Research Unit, Department of Anesthesiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Mol Pain 3:21. 2007
    ..We investigated whether neuropathic pain-related behavior in the spared nerve injury (SNI) rat model is dependent on the sympathetic nervous system...
  86. ncbi The modulator role of the hypothalamic paraventricular nucleus on immune responsiveness
    Vasile Hefco
    Al I Cuza University, Department of Physiology, Blv Carol I, no 11, Iasi 6600, Romania
    Brain Behav Immun 18:158-65. 2004
    ..antibody reduction after PVH manipulations was similar to that observed in rats that received a peripheral chemical sympathectomy two hrs prior immunization...
  87. ncbi Purinergic supersensitivity following sympathectomy adds further support to co-transmission in the rat vas deferens
    G C Rohde
    Department of Physiology, Faculty of Biological Sciences, Catholic University of Chile
    Arch Int Pharmacodyn Ther 294:99-111. 1988
    ..b>Chemical sympathectomy following a 48 hr 6-hydroxydopamine-treatment (6-OHDA) caused a leftward displacement of the concentration-..
  88. ncbi Robust experiment design for estimating myocardial beta adrenergic receptor concentration using PET
    Cristian Salinas
    Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Med Phys 34:151-65. 2007
    ..experiment design for PET was applied to experiments with pigs before and after beta-AR upregulation by chemical sympathectomy. Estimates of beta-AR concentration were found by minimizing the difference between the model-predicted ..
  89. ncbi Histochemical study of cardiac mast cells degranulation and collagen deposition: interaction with the cathecolaminergic system in the rat
    A Facoetti
    Department of Animal Biology, University of Pavia, Italy
    Eur J Histochem 50:133-40. 2006
    ..increase in mast cell activation associated with a lower extent of collagen deposition when compared to chemical sympathectomy. These data are the first demonstration of a close relationship between rat cardiac mast cell activation ..
  90. ncbi Effects of 6-hydroxydopamine on oxidative phosphorylation of mitochondria from rat striatum, cortex, and liver
    J H Thakar
    Parkinson s Disease Research Laboratory, Ottawa Civic Hospital, Ont, Canada
    Can J Physiol Pharmacol 66:376-9. 1988
    The catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) has been used to produce cardiac chemical sympathectomy as well as a model of parkinsonism...
  91. ncbi Innervation of immune cells: evidence for neuroimmunomodulation in the liver
    Winfried L Neuhuber
    Institute of Anatomy, University of Erlangen Nuremberg, Erlangen, Germany
    Anat Rec A Discov Mol Cell Evol Biol 280:884-92. 2004
    ..This was evidenced by recording morphological and functional parameters upon chemical sympathectomy and application of beta-adrenergic agonists, and capsaicin depletion of afferents, neurokinin receptor ..
  92. ncbi Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP38 content in the rat adrenals
    W J Ginda
    Department of Histology and Embryology, School of Medicine, Poznan, Poland
    Horm Metab Res 31:367-9. 1999
    ..In contrast, chemical sympathectomy, obtained by administering newborn rats with 6-hydroxydopamine, was ineffective...
  93. ncbi Non-neuronal dopamine in the gastrointestinal system
    E Mezey
    Basic Neuroscience Program, NINDS, Bethesda, Maryland 20892, USA
    Clin Exp Pharmacol Physiol Suppl 26:S14-22. 1999
    ..2. We found very high concentrations of DA that persisted after chemical sympathectomy (CS) in the gastric juice, the stomach mucosa and in the pancreas...
  94. ncbi S-100-immunoreactive nerves in the guinea-pig uterus with reference to ultrastructural correlations: effects of chemical sympathectomy and pregnancy
    L M Lundberg
    Department of Pathology, University of Lund, Sweden
    Cell Tissue Res 250:241-9. 1987
    ..In contrast, chemical sympathectomy produced by 6-hydroxydopamine did not change S-100 immunoreactivity of uterine nerves...
  95. ncbi Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers
    A Pertovaara
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Eur J Pharmacol 429:139-45. 2001
    ..Following chemical sympathectomy with 6-hydroxydopamine, antinociception was achieved at a lower dose ipsilaterally, than contralaterally, ..
  96. ncbi Autoradiographic localization of vascular dopamine receptors
    F Amenta
    Dipartimento di Scienze Neurologiche, , Rome, Italy
    Am J Hypertens 3:34S-36S. 1990
    ..Moreover, 3H-SCH 23390 binding sites were not sensitive to chemical sympathectomy, suggesting postjunctional localization of DA-1 receptors...
  97. ncbi [Repeated percutaneous chemical sympathectomy as a therapeutic option for treating PAD II]
    P Gaus
    Abteilung für Anästhesie und Intensivmedizin, Kliniken Dr Erler gGmbH, Kontumazgarten 4 18, 90429 Nürnberg, Deutschland
    Schmerz 24:625-8. 2010
    ..The case is an occasion to call for larger controlled studies designed to find out the efficacy of LSE for the treatment of stage II PAD. Mechanisms and available data are discussed...
  98. ncbi Radiation-induced brachial plexopathy in women treated for carcinoma of the breast
    Edward Fathers
    Department of Neurology, Derriford Hospital, Plymouth, UK
    Clin Rehabil 16:160-5. 2002
    ..To study the clinical presentation and natural history of radiation-induced brachial plexopathy in 33 women treated for carcinoma of the breast...
  99. ncbi Autoradiographic localization of dopamine DA-2 receptor sites in rat mesenteric vascular tree
    A Ricci
    Dipartimento di Scienze Neurologiche, Universita La Sapienza, Roma, Italy
    J Pharmacol Exp Ther 254:750-5. 1990
    ..In contrast, chemical sympathectomy was without effect on intimal [3H]spiroperidol binding sites...
  100. ncbi Neuropeptide tyrosine (NPY)-induced potentiation of the pressor activity of catecholamines in conscious rats
    L F Lopez
    Department of Physiology, Faculty of Biological Sciences, Catholic University, Santiago, Chile
    Peptides 10:551-8. 1989
    ..b>Chemical sympathectomy following 6-hydroxydopamine caused a marked supersensitivity to the catecholamines and NPY but obliterated ..
  101. ncbi A proposed role for nerve growth factor in the etiology of multiple sclerosis
    R C Olson
    Med Hypotheses 51:493-8. 1998
    ..They become more sensitive than controls to noradrenaline after chemical sympathectomy. Continued exposure to high noradrenaline can result in sympathectomy-like effects, heightening ..

Research Grants31

  1. Mechanisms mediating circadian oscillations of leukocyte migration
    Paul S Frenette; Fiscal Year: 2012
    ..Furthermore, using chemical sympathectomy and surgical denervation, we have found that the fluctuations of leukocyte recruitment were abolished in ..
  2. The Role of the Autonomic Nervous System in HSV Infection
    Andrea S Bertke; Fiscal Year: 2013
    ..model in vitro, by reactivating autonomic neurons from latently infected mice ex vivo, and by using a chemical sympathectomy model in vivo to determine if pathway ablation alters infection and reactivation patterns;and 3) to ..
  3. MECHANISM OF TRH EFFECTS IN FETAL LUNG DEVELOPMENT
    UDAY DEVASKAR; Fiscal Year: 1999
    ..TRH therapy in the HYT/HYT mouse with & without prior treatment with 6- hydroxydopamine (6-OHDA, chemical sympathectomy) or Propranolol (beta- adrenergic blockade) respectively: Absence of TRH effects on the lung in 6-OHDA or ..
  4. AUTONOMIC CONTROL OF LACRIMAL GLAND FUNCTION
    BARRY BROMBERG; Fiscal Year: 1980
    ..Parasympathectomy will be attempted by cauterization of the facial nerve. Chemical sympathectomy will be by systemic release of atropine from subcutaneous or intraperitoneal minipump or by direct ..
  5. SYSTEMIC AND LOCAL REGULATION OF MYOMETRIAL ACTIVITY
    Jorge Figueroa; Fiscal Year: 1993
    ..the role of the SAS in the initiation and/or modulation of ACTH induced parturition in sheep following chemical sympathectomy. Specific Aim 2: Study the effects of chemical sympathectomy in non-pregnant sheep on: in vivo response of ..
  6. BILE SECRETORY STUDIES IN THE TRANSPLANTED LIVER
    William Meyers; Fiscal Year: 1993
    ..Selective chemical sympathectomy caused a marked reduction in biliary cholesterol, phospholipi , and bile salt secretion during ..
  7. ANTI INFARCTION EFFECTS IN THE DENERVATED HEART
    PATRICIA GWIRTZ; Fiscal Year: 1993
    ..Four new studies are proposed: Study 10 will use conscious dogs and will examine whether chronic chemical sympathectomy [by topical application of phenol] exerts the same influence on the coronary collateral circulation as ..
  8. A CELL CYCLE STUDY OF DEVELOPING RAT SALIVARY GLANDS
    Robert Klein; Fiscal Year: 1980
    ..sympatholytic, and parasympatholytic drugs as well as by actual surgical denervation procedures and chemical sympathectomy. The normal cell cycle curve of each of the major salivary glands will be used as a foundation upon which ..
  9. EXERCISE AND ANIMAL MODELS OF HYPERTENSION
    CHARLES TIPTON; Fiscal Year: 1992
    ..b>Chemical sympathectomy and central injections of "putative transmitters" will be used to determine changes in the functioning of ..
  10. INACTIVATION OF NOREPINEPHRINE IN VASCULAR TISSUE
    JEROME LEVIN; Fiscal Year: 1980
    ..Standard regimens with 6-hydroxydopamine do not produce a good chemical sympathectomy in blood vessels...
  11. Effects of Maternal Diet on SNS Development in Offspring
    James Young; Fiscal Year: 2009
    ..Studies will examine effects of pharmacological interventions on the developing SNS, employing chemical sympathectomy in circumstances of increased SNS and neuroprotective agents in settings of decreased SNS, and assessing ..
  12. Cytokine and MAP Kinase Involvement in Neuropathic Pain
    Linda Sorkin; Fiscal Year: 2008
    ..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
  13. Chronic Alcohol & AIDS Impact on Muscle Wasting
    Patricia Molina; Fiscal Year: 2006
    ..abstract_text> ..
  14. RENAL ANGIOTENSIN II RECEPTOR AND SODIUM INTAKE
    Donna Wang; Fiscal Year: 2007
    ..abstract_text> ..
  15. Ca permeable non-NMDAr: New spinal sensitization pathway
    Linda Sorkin; Fiscal Year: 2005
    ..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
  16. Annual Meeting of the American Pain Society
    Linda Sorkin; Fiscal Year: 2005
    ..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
  17. ENVIRONMENTAL TEMPERATURE, SNS DEVELOPMENT AND OBESITY
    James Young; Fiscal Year: 2005
    ..The potential impact of changes in sympathetic activity regulated by RPa for glucose and energy metabolism will also be examined. ..
  18. Molecular Basis of D1 and D2 Priming
    Alexia Pollack; Fiscal Year: 2003
    ..Elucidation of this mechanism could lead to treatment strategies aimed to prevent these dyskinesias, which would, in turn, lengthen the time that dopamine replacement therapy is effective to treat patients with PD. ..
  19. EPIDERMAL GROWTH FACTOR, OBESITY & INSULIN RESISTANCE
    James Young; Fiscal Year: 2001
    ..A principal tenet of this proposal is that early life events which predispose animals to become obese differ from those which promote subsequent development in insulin resistance. ..
  20. BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSION
    David Wirtshafter; Fiscal Year: 2003
    ..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
  21. Cannabinoid effects on HIV/AIDS
    Patricia E Molina; Fiscal Year: 2010
    ....
  22. Alcoholism and Disease: Immune /Pathological Mechanisms
    Patricia Molina; Fiscal Year: 2002
    ..The proceedings of these symposia will be published and a summary report to the NIAAA will be prepared. ..
  23. Molecular Sensing of Sodium Homeostasis: Anandamide Role
    Donna Wang; Fiscal Year: 2009
    ....
  24. IMPROVED CELL COUNTING USING THE OPTICAL DISECTOR
    CHRISTOPHER VON BARTHELD; Fiscal Year: 2004
    ....
  25. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
    ..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
  26. Estrogenic LXR Alpha Response /Cholesterol Homeostasis
    Phillip Kramer; Fiscal Year: 2003
    ..abstract_text> ..
  27. WAGES: Workplace Activity for Employee Goal Setting
    RODNEY DISHMAN; Fiscal Year: 2006
    ..The project will implement and rigorously evaluate a multilevel physical activity intervention that has potential for broad application to workplace health promotion. ..
  28. NEURAL MECHANISMS OF CYCLOSPORINE-INDUCED HYPERTENSION
    Robert Augustyniak; Fiscal Year: 2003
    ..abstract_text> ..
  29. PERINATAL HYPOXIA: ADRENOCORTICAL-METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 2006
    ..Characterization of the hypothalamic-pituitary-adrenal and metabolic adaptations to perinatal hypoxia can lead to new diagnostic approaches and therapies to minimize morbidity and mortality. ..
  30. Estrogenic Regulation of Inflammation Related to TMJD
    Phillip Kramer; Fiscal Year: 2006
    ..The function of estrogen receptors ER alpha and/or ER beta will be directly addressed pharmacologically (e.g., antiestrogen) and through mutation studies of the Fc gamma RIIIA promoter. ..
  31. Volatile Anesthetic Action in Vertebrate Locomotor Systems
    Steven L Jinks; Fiscal Year: 2010
    ..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..