Genomes and Genes
Summary: Sympathectomy using chemicals (e.g., 6-hydroxydopamine or guanethidine) which selectively and reversibly destroy adrenergic nerve endings while leaving cholinergic nerve endings intact.
Publications205 found, 100 shown here
- Modulation of visceral nociceptive responses of rat spinal dorsal horn neurons by sympathectomyJ Kalmari
Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
Neuroreport 12:797-801. 2001....
- Chemical sympathectomy alters food intake and thermogenic responses to catecholamines in ratsIvan Villanueva
Departamento de Fisiologia, Escuela Nacional de Ciencias Biologicas, I P N México, 11340 Col Casco de Sto Tomás, Mexico
Life Sci 71:789-801. 2002..Compared with controls, Gnt-treated rats also showed a limited thermogenic capacity not related to feeding, and a greater degree of carbohydrate oxidation, possibly due to a defect in E-induced lipolysis, which is beta-adrenergic...
- Rat heart GDNF: effect of chemical sympathectomyPatricia M Martinelli
Department of Morphology, Institute of Biological Sciences ICB, Federal University of Minas Gerais UFMG, 31270 901 Belo Horizonte, MG, Brazil
Histochem Cell Biol 118:337-43. 2002..In this work, chemical sympathectomy by 6-hydroxydopamine provided the model for assessing heart GDNF expression during denervation and axonal ..
- Positron emission imaging of cardiac sympathetic innervation and function using 18F-6-fluorodopamine: effects of chemical sympathectomy by 6-hydroxydopamineD S Goldstein
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892
J Hypertens 9:417-23. 1991..PET) scanning after systemic intravenous injection of 18F-6-fluorodopamine, and the effects of chemical sympathectomy by the neurotoxin, 6-hydroxydopamine (6-OHDA)...
- Preservation of the baroreceptor heart rate reflex by chemical sympathectomy in experimental heart failureLuca Mircoli
Divisione di Cardiologia, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
Circulation 106:866-72. 2002..The purpose of the present study was to test the hypothesis that this alteration depends on the marked degree of sympathetic overactivity known to characterize the CHF syndrome...
- Chemical sympathectomy inhibits periodontal disease in Fischer 344 ratsTorbjørn Breivik
Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway
J Periodontal Res 40:325-30. 2005....
- Sympathetic neural modulation of the immune system. I. Depression of T cell immunity in vivo and vitro following chemical sympathectomyK S Madden
Department of Microbiology, University of Rochester Medical Center, New York 14642
Brain Behav Immun 3:72-89. 1989b>Chemical sympathectomy of adult mice with 6-hydroxydopamine (6-OHDA) either prior to or following epicutaneous sensitization with the trinitrophenyl (TNP) hapten decreased the delayed hypersensitivity (DH) response to ear challenge...
- The effects of chemical sympathectomy on testicular injury in varicoceleH Ozturk
Department of Paediatric Surgery, and Animal Research Center, Gulhane Military Medical Academy, Ankara, Turkey
BJU Int 87:232-4. 2001..To determine whether the sympathetic nervous system plays a role in the contralateral testicular deterioration encountered in varicocele...
- Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusionRobert L Dobbins
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
Am J Physiol Endocrinol Metab 284:E778-87. 2003..After neonatal chemical sympathectomy, changes in weight and food intake were compared in groups of sympathectomized (SYM) and control (CON) ..
- Chemical sympathectomy for neuropathic pain: does it work? Case report and systematic literature reviewA D Furlan
Comprehensive Pain Program, The Toronto Western Hospital, and Institute for Work and Health, Ontario, Canada
Clin J Pain 17:327-36. 2001To determine if chemical sympathectomy successfully reduces limb neuropathic pain.
- The influence of chemical sympathectomy on pain responsivity and alpha 2-adrenergic antinociception in neuropathic animalsH Wei
Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Neuroscience 114:655-68. 2002We studied the effect of chemical sympathectomy by 6-hydroxydopamine (6-OHDA) on pain behavior and alpha(2)-adrenergic antinociception in rats with a spinal nerve ligation-induced neuropathy...
- Chemical sympathectomy-induced changes in TH-, VIP-, and CGRP-immunoreactive fibers in the rat mandible periosteum: influence on bone resorptionM Cherruau
Laboratoire de Biologie et Physiopathologie Cranio faciales, Faculte de Chirurgie Dentaire, Universite Rene Descartes Paris 5, Arnoux Montrouge, France
J Cell Physiol 194:341-8. 2003..Nevertheless, these fibers did not originate from the SCG, contrary to TH-IR fibers...
- Monoamine oxidase (MAO) in pancreatic islets of the mouse: some characteristics and the effect of chemical sympathectomyA Stenstrom
Department of Pharmacology University of Umea, Sweden
Diabetes Res 11:81-4. 1989We have previously observed that chemical sympathectomy in the guinea pig induced an increase in the intensity of serotonin fluorescence in the insulin cells of the pancreatic islets...
- Pulmonary vascular responses to surgical chemodenervation and chemical sympathectomy in dogsR Naeije
Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
J Appl Physiol (1985) 66:42-50. 1989We investigated the effects of surgical peripheral chemoreceptor denervation, chemical sympathectomy with 6-hydroxydopamine (6-OHDA), and the peripheral chemoreceptor stimulant almitrine on multipoint pulmonary arterial pressure-cardiac ..
- Capsaicin-induced corneal lesions in mice and the effects of chemical sympathectomyT Shimizu
Department of Pharmacology, Faculty of Medicine, Kagoshima University, Japan
J Pharmacol Exp Ther 243:690-5. 1987Effects of chemical sympathectomy on corneal changes induced in mice by a s.c. injection of capsaicin were investigated. Pretreatment with a s.c...
- Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesionsG M Pasinetti
Department of Psychiatry, Mt Sinai School of Medicine, New York, New York 10029 6574, USA
Synapse 31:278-84. 1999..We conclude that aging changes in striatal GFAP mRNAs do not interact with loss of dopaminergic output to the striatum from 6-OHDA lesions and may be independent of the relatively modest dopaminergic losses during normal aging...
- Firing regulation in dopaminergic cells: effect of the partial degeneration of nigrostriatal system in surviving neuronsManuel Rodriguez
Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain
Eur J Neurosci 18:53-60. 2003..Under these conditions, small fluctuations in firing rate are not compensated for in time, which could be one of the factors responsible for the motor fluctuations often observed in advanced Parkinson's disease...
- In vivo stimulation of sympathetic nervous system modulates osteoblastic activity in mouse calvariaAyami Kondo
Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
Am J Physiol Endocrinol Metab 285:E661-7. 2003..These results indicate that in vivo adrenergic stimulation modulates the osteoblastic activity in mouse calvaria via noradrenergic nerve terminals...
- High frequency stimulation of the subthalamic nucleus improves treadmill locomotion in unilateral 6-hydroxydopamine lesioned ratsJing Yu Chang
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Brain Res 983:174-84. 2003..This work may provide a rodent model for deep brain stimulation (DBS) in patients with Parkinson's disease, and be suitable for further investigation of the neural mechanisms underlying the therapeutic effects of DBS...
- Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibersLinda S Sorkin
Department of Anesthesiology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
Exp Neurol 184:162-8. 2003..Information on pain and inflammation in the periphery is transmitted to the nervous system, where increased spinal adenosine levels can suppress peripheral inflammation...
- Interaction between serotonergic and noradrenergic axons during axonal regenerationYing Liu
Department of Neuroscience, Yamaguchi University School of Medicine, 755 8505, Ube, Yamaguchi, Japan
Exp Neurol 184:169-78. 2003..The differential roles of 5-HT and NA axons in axonal regeneration may play a role in a variety of physiological functions related to these monoamines and possibly in the pathophysiology of clinical depression...
- Cholecystokinin-8 promotes recovery of sympathectomy induced by 6-hydroxydopamine in adult miceL Manni
Institute of Neurobiology (CNR, Rome, Italy
Neuroreport 12:1621-7. 2001..This latter observation suggests that the effect of CCK-8 might be mediated through the stimulation of NGF synthesis...
- Upregulation of striatal adenosine A2A receptor mRNA in 6-hydroxydopamine-lesioned rats intermittently treated with L-DOPAMasahiko Tomiyama
Third Department of Medicine, Hirosaki University School of Medicine, Hirosaki 036 8216, Japan
Synapse 52:218-22. 2004..These results suggest that A2A receptor activation is associated with the development of motor complications induced by L-DOPA treatment...
- Chemical sympathectomy increases numbers of inflammatory cells in the peritoneum early in murine listeriosisP A Rice
Department of Pulmonary and Critical Care Medicine, University of Maryland, 3C116, VAMC 10 N Greene Street, Baltimore, MD 21201, USA
Brain Behav Immun 16:654-62. 2002..This suggests that sympathectomy-induced decreases systemic bacterial loads are associated with increased recruitment of inflammatory cells into tissues during the innate immune response...
- Behaviorally conditioned immunosuppression in the rat is regulated via noradrenaline and beta-adrenoceptorsMichael S Exton
Department of Medical Psychology, University of Essen, Hufelandstr 55, 45122, Essen, Germany
J Neuroimmunol 131:21-30. 2002..b>Chemical sympathectomy via 6-OHDA completely blocked the conditioned suppression of splenocyte proliferation to mitogens and ..
- Chemical sympathectomy alters numbers of splenic and peritoneal leukocytesP A Rice
Department of Environmental Medicine, University of Rochester School of Medicine, New York 14642, USA
Brain Behav Immun 16:62-73. 2002..Sympathectomy did not affect tumor necrosis factor-alpha, interleukin-12, or interferon-gamma production in cultured splenocytes or PEC in either infected or uninfected mice...
- Stereoselective effects of methylphenidate on motor hyperactivity in juvenile rats induced by neonatal 6-hydroxydopamine lesioningEugen Davids
Department of Psychiatry and Neuroscience Program, Harvard Medical School and Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
Psychopharmacology (Berl) 160:92-8. 2002..The enantiomers of methylphenidate differ markedly in stimulant potency but have not been compared in the 6-OHDA lesion model...
- 6-Hydroxydopamine-lesioning of the nigrostriatal pathway in rats alters basal ganglia mRNA for copper, zinc- and manganese-superoxide dismutase, but not glutathione peroxidaseG Kunikowska
Neurodegenerative Diseases Research Centre, Division of Pharmacology and Therapeutics, Guy's, King's and St Thomas' School of Biomedical Sciences, Hodgkin Building, King's College, London SE1 1UL, UK
Brain Res 922:51-64. 2001..These findings may clarify the status of antioxidant enzymes, particularly Mn-SOD, in patients with Parkinson's disease and their relevance to disease pathogenesis...
- [Effect of chemical sympathectomy on myoelectric activity of the small bowel]B Koprowska
Katedra Patofizjologii Collegium Medicum UJ ul. Czysta 18,
Folia Med Cracov 42:75-81. 2001..CONCLUSION: Peripheral noradrenergic system has a significant effect on the frequency and variability of slow wave and minor role on its amplitude but no on diarrhoea pattern...
- Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic ratsQi Mei
Division of Endocrinology and Metabolism, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Diabetes 51:2997-3002. 2002..Because eSIN occurs selectively in the islet, is rapid in onset, and is associated with autoimmune but not chemically induced diabetes, it is distinct from DAN in location, time course, and mechanism...
- Sympathetic nervous system plays a major role in acute cold/restraint stress inhibition of host resistance to Listeria monocytogenesLing Cao
Wadsworth Center, New York State Department of Health, Empire State Plaza, P O Box 509, Albany, NY 12201 0509, USA
J Neuroimmunol 125:94-102. 2002..of CORT and NE was investigated by pretreating mice with the CORT synthesis inhibitor metyrapone and the chemical sympathectomy drug 6-hydroxydopamine (6-OHDA), respectively...
- Effects of infantile/prepubertal chronic estrogen treatment and chemical sympathectomy with guanethidine on developing cholinergic nerves of the rat uterusAnalía Richeri
Laboratorio de Biologia Celular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
J Histochem Cytochem 50:839-50. 2002..in this study we analyzed the effects of infantile/prepubertal chronic estrogen treatment, chronic chemical sympathectomy with guanethidine, and combined sympathectomy and chronic estrogen treatment on developing cholinergic ..
- Evaluation of the mGluR2/3 agonist LY379268 in rodent models of Parkinson's diseaseTracey K Murray
Lilly Research Centre, Eli Lilly and Co Ltd, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK
Pharmacol Biochem Behav 73:455-66. 2002..These data suggest that activation of Group II mGlu receptors can provide some protection in models of PD, while their role in providing functional improvement is less clear...
- A comparison of two behavioral measures of psychomotor activation following intravenous amphetamine or cocaine: dose- and sensitization-dependent changesH S Crombag
Department of Psychology, The University of Michigan, Ann Arbor 48109 1109, USA
Behav Pharmacol 10:205-13. 1999..The data highlight the advantages and disadvantages of these measures as indices of the psychomotor activating effects of psychostimulant drugs...
- Fixed ratio discrimination training increases in vivo striatal dopamine in neonatal 6-OHDA-lesioned ratsPippa S Loupe
Schiefelbusch Institute for Life Span Studies, 1052 Dole Human Development Center, University of Kansas, Lawrence, KS 66045, USA
Pharmacol Biochem Behav 74:61-71. 2002....
- Locomotor stimulant effects of nornicotine: role of dopamineT A Green
Department of Psychology, University of Kentucky, Lexington, KY 40506 0044, USA
Pharmacol Biochem Behav 74:87-94. 2002....
- Effects of chemical sympathectomy by means of 6-hydroxydopamine on insulin secretion and islet morphology in alloxan-diabetic miceMartina Kvist-Reimer
Department of Medicine, Lund University, B11 BMC, 221 84 Lund, Sweden
Cell Tissue Res 307:203-9. 2002..In this study, we tested whether elimination of sympathetic nerve activity by chemical sympathectomy with 6-hydroxydopamine (6-OHDA; 60 mg/kg) ameliorates the diabetogenic effects of alloxan (50 mg/kg) in ..
- PNU-96391A (OSU6162) antagonizes the development of behavioral sensitization induced by dopamine agonists in a rat model for Parkinson's diseaseN F Nichols
Neurobiology Research, Pharmacia Corporation, Kalamazoo, MI 49001, USA
Neuropharmacology 43:817-24. 2002..These results suggest that PNU-96391A could be therapeutically useful to prevent the development of behavioral sensitization induced by DA agonists...
- Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleusNasser Haddjeri
Laboratory of Neuropharmacology and Neurochemistry INSERM U512, University Claude Bernard, Avenue Rockfeller, Lyon, France
Neuropsychopharmacology 29:1800-6. 2004..When the fluctuations of the function of NE neurons normally produced by WAY 100,635 were prevented, a tonic activation of 5-HT(1A) autoreceptors by endogenous 5-HT was unmasked...
- Age and gender differences in behavioral and morphological outcome after 6-hydroxydopamine-induced lesion of the substantia nigra in ratsAndrea Tamas
Department of Anatomy, Neurohumoral Regulations Research Group of the Hungarian Academy of Sciences, University Medical Faculty, Szigeti u 12, 7624 Pecs, Hungary
Behav Brain Res 158:221-9. 2005..In summary, our present results showed clear age- and gender differences in the behavioral and histological outcome following 6-OHDA lesion of the substantia nigra...
- Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administrationA H Rezvani
Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
Neuroscience 154:885-97. 2008..These results show that interfering with normal dopamine innervation of the frontal cortex during early postnatal development has persisting behavioral effects, which are sex-specific...
- Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulbBeate Winner
Department of Neurology, University of Regensburg, Regensburg, Germany
Exp Neurol 197:113-21. 2006..This study supports the accumulating evidence that neurotransmitters play a crucial role in determining survival and differentiation of newly generated neurons...
- Subchronic intermittent caffeine administration to unilaterally 6-hydroxydopamine-lesioned rats sensitizes turning behaviour in response to dopamine D(1) but not D(2) receptor agonistsOmar Cauli
Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
Behav Pharmacol 16:621-6. 2005..The results show that repeated intermittent caffeine exposure enhances the motor stimulant effects elicited by dopamine agonists by a preferential sensitization of dopamine D(1) receptors...
- Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortexS M Clinton
Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
Psychopharmacology (Berl) 183:404-12. 2006....
- A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental areaLéder Leal Xavier
Departamento de Ciencias Fisiologicas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Rua Ipiranga 6681, CEP 90619 900, Porto Alegre, RS, Brazil
Brain Res Brain Res Protoc 16:58-64. 2005..We believe that this protocol will facilitate the evaluation of mesencephalic TH immunoreactivity in various available animal models of Parkinson's disease...
- Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's diseaseNicholas M Kanaan
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Brain Res 1068:221-9. 2006..As direct neurotrophic effects of Epo were not observed in vitro, the mechanism of Epo neuroprotection remains to be elucidated...
- L-DOPA inhibits depolarization-induced [3H]GABA release in the dopamine-denervated globus pallidus of the rat: the effect is dopamine independent and mediated by D2-like receptorsI Silva
Departamento de Fisiologia, Biofísica y Neurociencias del CINVESTAV, Mexico, Mexico
J Neural Transm 113:1847-53. 2006..L-DOPA could control Parkinson's disease symptoms acting not only as dopamine precursor but also by itself...
- Changes in dopamine D2 receptors and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine uptake in the brain of 6-hydroxydopamine-lesioned ratsYasushi Ishida
Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
Neurodegener Dis 1:109-12. 2004..Therefore, the combination of a D2 antagonist and FDOPA may provide a potentially useful method for assessing the effects of dopamine depletion in Parkinson's disease...
- Nicotine's attenuation of body weight involves the perifornical hypothalamusPhillip R Kramer
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, 3302 Gaston Ave Dallas, TX 75246, USA
Life Sci 81:500-8. 2007..These results are consistent with NIC reducing food intake in part by acting through catecholaminergic neurons within or extending through the PFH...
- Requirement of intact sympathetic transmission for the ocular hypotensive effects of melatonin and 5-MCA-NATPilar Alarma-Estrany
Departamento de Bioquimica, Universidad Complutense de Madrid, 28037 Madrid, Spain
Auton Neurosci 137:63-6. 2007..After chemical sympathectomy by reserpine or 6-hydroxydopamine, the hypotensive effects of melatonin and 5-MCA-NAT are severely ..
- Locus coeruleus noradrenergic neurons and CO2 drive to breathingVivian Biancardi
Department of Animal Morphology and Physiology, Sao Paulo State University UNESP FCAV, Jaboticabal, SP, Brazil
Pflugers Arch 455:1119-28. 2008..Thus, we conclude that LC noradrenergic neurons modulate hypercapnic ventilatory response but play no role in cardiovascular and thermal regulation under resting conditions...
- [Behavioral evaluation of the unilateral lesion model in rats using 6-hydroxydopamine. Correlation between the rotations induced by D-amphetamine, apomorphine and the manual dexterity test]N Pavon
Centro Internacional de Restauracion Neurologica, CIREN, La Habana, Cuba
Rev Neurol 26:915-8. 1998....
- Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulationS Li
Biology Department, Emory University, Atlanta, GA 30322, USA
J Neurophysiol 98:3525-37. 2007..Thus antidromic resonant activation of cortical microcircuits may make an important contribution toward counteracting the overly synchronous and oscillatory activity characteristic of cortical activity in PD...
- Sympathetic pharmacological denervation in ageing rats: effects on ovulatory response and follicular populationRebeca Chávez-Genaro
Histology and Embryology Department, School of Medicine, General Flores 2125, CP 11800, Montevideo, Uruguay
Reprod Fertil Dev 19:954-60. 2007..The action of ovarian noradrenergic innervation seems to be associated with folliculogenesis and the ovarian response to gonadotrophins...
- Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6N Yamamoto
Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Room L1004, Boston, MA 02118, USA
Neuroscience 154:1088-99. 2008..They also suggest that the down-regulation of nigral GABA(A) receptors is linked to the increase in striatal GAD67 mRNA levels in the dopamine-depleted striatum...
- Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson's diseaseT P Harrower
Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
Exp Neurol 197:56-69. 2006..This demonstrates that such xenografted cells may be able to recreate the damaged circuitry in PD although strategies for dopaminergic differentiation of the porcine neural precursor cell remain to be refined...
- Ultra violet-induced localized inflammatory hyperalgesia in awake rats and the role of sensory and sympathetic innervation of the skinNayef E Saade
Department of Human Morphology, Faculty of Medicine, American University of Beirut, Riad E1 Solh Beirut, Beirut 1107 2020, Lebanon
Brain Behav Immun 22:245-56. 2008....
- Receptor binding occurrence and plasma levels of natriuretic peptides in response to sympathectomyMagnus Hansson
Department of Integrative Medical Biology, Section for Anatomy, and Department of Medical Biosciences, Section for Pathology, Umea University, SE 901 87 Umea, Sweden
Microsc Res Tech 67:90-9. 2005..In order to destruct the cardiac sympathetic nerve terminals, chemical sympathectomy with 6-hydroxydopamine was made in parallel with intravenous measurements of blood pressure and heart ..
- Serotonin 5-HT2A but not 5-HT2C receptor antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the D1 agonist SKF 82958Christopher Bishop
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield, Detroit, MI 48201, USA
Neuropharmacology 49:350-8. 2005..These results indicate that DA depletion strengthens striatal 5-HT2A/D1 receptor interactions and suggest that 5-HT2A receptor antagonists may prove useful in reducing D1-related movements...
- Stress reduces the neuroprotective effect of exercise in a rat model for Parkinson's diseaseFleur M Howells
Division of Physiology, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Room 5 02, Anatomy Building, South Africa
Behav Brain Res 165:210-20. 2005..The behavioural results confirm a previous finding suggesting that voluntary exercise is neuroprotective. A novel finding is that mild stressors cancel the neuroprotection afforded by voluntary exercise...
- Sympathetic denervation does not prevent a reduction in fat pad size of rats or mice treated with peripherally administered leptinCherie R Rooks
Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30602, USA
Am J Physiol Regul Integr Comp Physiol 289:R92-102. 2005..These changes in intact pads of rats with one denervated fat pad imply communication between fat depots and suggest that both leptin and the SNS regulate the size of individual depots...
- The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959Xuechu Zhen
Department of Physiology Pharmacology, City University of New York Medical School, 138th Street and Convent Ave New York, NY 10031, USA
Pharmacol Biochem Behav 80:597-601. 2005....
- Dissociation of hemi-spatial and hemi-motor impairments in a unilateral primate model of Parkinson's diseaseA L Milton
Department of Experimental Psychology, Downing Street, Cambridge CB3 2EB, UK
Behav Brain Res 150:55-63. 2004..Patients with bilateral Parkinson's symptoms may exhibit bilateral deficits in mental representation...
- Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and alpha6 and beta3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the ratN P Visanji
King s College London, Wolfson Centre for Age Related Diseases, Wolfson Wing, Hodgkin Building, UK
Neuropharmacology 50:36-46. 2006....
- Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of ParkinsonismA Lopez-Real
Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
J Neurosci Res 81:865-73. 2005..Our results suggest that angiotensin-converting enzyme inhibitors may be useful for treatment of Parkinson's disease and that further investigation should focus on the neuroprotective capacity of these compounds...
- alpha1-Adrenoceptors in proximal segments of tail arteries from control and reserpinised ratsSusana Y Kamikihara
Department of Pharmacology, Instituto de Biociencias, UNESP, Botucatu, SP 18618 000, Brazil
Naunyn Schmiedebergs Arch Pharmacol 376:117-26. 2007..recently shown that the supersensitivity of distal segments of the rat tail artery to phenylephrine after chemical sympathectomy with reserpine results from the appearance of alpha(1D)-adrenoceptors...
- Pronociceptive response elicited by TRPA1 receptor activation in miceE L Andrade
Department of Pharmacology, Federal University of Santa Catarina, CCB, Campus Universitario Trindade, 88049 900, Florianopolis, SC, Brazil
Neuroscience 152:511-20. 2008..Moreover, capsaicin and allyl isothiocyanate-induced nociception were not significantly changed by chemical sympathectomy produced by guanethidine...
- Role of sympathetic nervous system in experimental hypertension and diabetes mellitusC L Kaul
National Institute of Pharmaceutical Education and Research, S A S Nagar Mohali, Punjab, India
Clin Exp Hypertens 21:95-112. 1999..b>Chemical sympathectomy with 6-OHDA did not show any glucose intolerance in rhesus monkeys or any effect or insulin release...
- Mechanism of bradykinin-induced plasma extravasation in the rat knee jointH Cambridge
Pharmacology Group, King s College London
Br J Pharmacol 115:641-7. 1995..4. Chemical sympathectomy by chronically administered 6-hydroxydopamine (6-OHDA) did not inhibit bradykinin-induced plasma ..
- Increased dopamine-beta-hydroxylase-like immunoreactivity in non-noradrenergic axons supplying the guinea-pig uterine artery after 6-hydroxydopamine treatmentJ L Morris
Department of Anatomy and Histology, Flinders University of South Australia, Bedford Park
J Auton Nerv Syst 21:15-27. 1987..After chemical sympathectomy with 6-OHDA, the levels of DBH immunoreactivity in axons of non-noradrenergic neurons increased, and more ..
- Effect of 6-hydroxydopamine on gluconeogenesis in the rat renal cortexC Cojocel
Faculty of Medicine, Department of Pharmacology and Toxicology, Kuwait University, Safat, Kuwait
Clin Exp Pharmacol Physiol 30:55-9. 2003..2. 6-Hydroxydopamine is used for chemical sympathectomy because it selectively destroys adrenergic nerve endings...
- Peripheral, but not central nervous system, type I interferon expression in mice in response to intranasal vesicular stomatitis virus infectionMark D Trottier
Biology Department, New York University, New York, NY 10003, USA
J Neurovirol 13:433-45. 2007..Experiments with chemical sympathectomy, sRAGE, and neutralizing antibody to VSV were performed to investigate the mechanism(s) utilized for ..
- Role of sympathoadrenomedullary system in cardiovascular response to stress in ratsB A Barron
Department of Medicine, University of Kentucky, Lexington
J Auton Nerv Syst 28:179-87. 1989..responses were investigated by factoring out their influence using adrenal demedullation (DMED) and/or chemical sympathectomy with guanethidine (GUAN)...
- Imidazoline receptor mediated natriuresis: central and/or peripheral effect?D D Smyth
Department of Pharmacology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
J Auton Nerv Syst 72:155-62. 1998..Finally, chemical sympathectomy with reserpine did not alter the response to intrarenal moxonidine suggesting that this effect was ..
- Sympathetic nervous system mediates central corticotropin-releasing factor induced suppression of natural killer cytotoxicityM Irwin
Department of Psychiatry, San Diego Veterans Administration Medical Center, California
J Pharmacol Exp Ther 255:101-7. 1990..Pretreatment of the animals by chemical sympathectomy (6-hydroxy-dopamine, 100 mg/kg i.p...
- Sympathetic histamine exerts different pre- and post-synaptic functions according to the frequencies of nerve stimulation in guinea pig vas deferensGonghao He
Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an, China
J Neurochem 106:1710-9. 2008..and mast cell stabilizer cromolyn, but was highly sensitive to Na(+) channel blocker tetrodotoxin and chemical sympathectomy with 6-hydroxydopamine. The neurogenically released HA evoked by 12...
- Effect of pre-existing inflammation on carrageenan-induced paw oedema in ratsS K Bhattacharya
Department of Pharmacology, Banaras Hindu University, Varanasi, India
J Pharm Pharmacol 39:854-6. 1987..inflammatory response in the contralateral paw after 24 h was antagonized by bilateral adrenalectomy and chemical sympathectomy induced by 6-hydroxydopamine...
- Laparoscopic lumbar sympathectomy for lower-limb diseaseS Watarida
Second Department of Surgery, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520 2192, Japan
Surg Endosc 16:500-3. 2002..b>Chemical sympathectomy has been introduced as a less invasive means of achieving sympatholysis; however, this method is also ..
- Occurrence of adrenergic nerve fibers and of noradrenaline in thymus gland of juvenile and aged ratsC Cavallotti
Department of Cardiovascular and Respiratory Sciences, University of Rome La Sapienza, Italy
Immunol Lett 70:53-62. 1999..After chemical sympathectomy with neurotoxin 6-OH dopamine, the greater part of ANF disappeared...
- Catecholamine depletion by reserpine blocks the anxiolytic actions of ethanol in the ratChristopher J LaBuda
Department of Psychology, Box 19528, University of Texas at Arlington, Arlington, TX 76019, USA
Alcohol 26:55-9. 2002..The present study examined the effect of chemical sympathectomy by reserpine pretreatment on the subsequent anxiolytic action of ethanol...
- Activity-wheel running blunts suppression of splenic natural killer cell cytotoxicity after sympathectomy and footshockR K Dishman
Department of Exercise Science, The University of Georgia, 30602 6554, Athens, GA, USA
Physiol Behav 71:297-304. 2000We used chemical sympathectomy by 6-hydroxydopamine (6-OHDA) to examine whether adaptation by the sympathetic nervous system (SNS) is a plausible explanation for our prior finding that activity-wheel running blunts the suppression of ..
- Loss-of-function mutation of the galanin gene is associated with perturbed islet function in miceBo Ahren
Department of Medicine, Lund University, B11 Biomedical Centre, SE 221 84 Lund, Sweden
Endocrinology 145:3190-6. 2004..01). Similar effects were seen after chemical sympathectomy by 6-hydroxydopamine...
- Lack of beneficial effect of a tachykinin receptor antagonist in experimental colitisJ L Wallace
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Alberta, Canada
Regul Pept 73:95-101. 1998..Studies in an experimental model of colitis have demonstrated that neuromodulation, through chemical sympathectomy or administration of lidocaine, can markedly attenuate granulocyte infiltration and tissue injury...
- Sympathectomy-induced immune changes are not abrogated by the glucocorticoid receptor blocker RU-486B Kruszewska
Center for Psychoneuroimmunology Research, University of Rochester Medical Center, Rochester, New York, 14642, USA
Brain Behav Immun 12:181-200. 1998..This examines the possible role of glucocorticoids in these previously reported changes. In both strains, chemical sympathectomy triggers an elevation of glucocorticoid levels immediately following injection of 6-OHDA, returning to ..
- Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic painMarie Pertin
Anesthesiology Pain Research Unit, Department of Anesthesiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
Mol Pain 3:21. 2007..We investigated whether neuropathic pain-related behavior in the spared nerve injury (SNI) rat model is dependent on the sympathetic nervous system...
- The modulator role of the hypothalamic paraventricular nucleus on immune responsivenessVasile Hefco
Al I Cuza University, Department of Physiology, Blv Carol I, no 11, Iasi 6600, Romania
Brain Behav Immun 18:158-65. 2004..antibody reduction after PVH manipulations was similar to that observed in rats that received a peripheral chemical sympathectomy two hrs prior immunization...
- Purinergic supersensitivity following sympathectomy adds further support to co-transmission in the rat vas deferensG C Rohde
Department of Physiology, Faculty of Biological Sciences, Catholic University of Chile
Arch Int Pharmacodyn Ther 294:99-111. 1988..b>Chemical sympathectomy following a 48 hr 6-hydroxydopamine-treatment (6-OHDA) caused a leftward displacement of the concentration-..
- Robust experiment design for estimating myocardial beta adrenergic receptor concentration using PETCristian Salinas
Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
Med Phys 34:151-65. 2007..experiment design for PET was applied to experiments with pigs before and after beta-AR upregulation by chemical sympathectomy. Estimates of beta-AR concentration were found by minimizing the difference between the model-predicted ..
- Histochemical study of cardiac mast cells degranulation and collagen deposition: interaction with the cathecolaminergic system in the ratA Facoetti
Department of Animal Biology, University of Pavia, Italy
Eur J Histochem 50:133-40. 2006..increase in mast cell activation associated with a lower extent of collagen deposition when compared to chemical sympathectomy. These data are the first demonstration of a close relationship between rat cardiac mast cell activation ..
- Effects of 6-hydroxydopamine on oxidative phosphorylation of mitochondria from rat striatum, cortex, and liverJ H Thakar
Parkinson s Disease Research Laboratory, Ottawa Civic Hospital, Ont, Canada
Can J Physiol Pharmacol 66:376-9. 1988The catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) has been used to produce cardiac chemical sympathectomy as well as a model of parkinsonism...
- Innervation of immune cells: evidence for neuroimmunomodulation in the liverWinfried L Neuhuber
Institute of Anatomy, University of Erlangen Nuremberg, Erlangen, Germany
Anat Rec A Discov Mol Cell Evol Biol 280:884-92. 2004..This was evidenced by recording morphological and functional parameters upon chemical sympathectomy and application of beta-adrenergic agonists, and capsaicin depletion of afferents, neurokinin receptor ..
- Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP38 content in the rat adrenalsW J Ginda
Department of Histology and Embryology, School of Medicine, Poznan, Poland
Horm Metab Res 31:367-9. 1999..In contrast, chemical sympathectomy, obtained by administering newborn rats with 6-hydroxydopamine, was ineffective...
- Non-neuronal dopamine in the gastrointestinal systemE Mezey
Basic Neuroscience Program, NINDS, Bethesda, Maryland 20892, USA
Clin Exp Pharmacol Physiol Suppl 26:S14-22. 1999..2. We found very high concentrations of DA that persisted after chemical sympathectomy (CS) in the gastric juice, the stomach mucosa and in the pancreas...
- S-100-immunoreactive nerves in the guinea-pig uterus with reference to ultrastructural correlations: effects of chemical sympathectomy and pregnancyL M Lundberg
Department of Pathology, University of Lund, Sweden
Cell Tissue Res 250:241-9. 1987..In contrast, chemical sympathectomy produced by 6-hydroxydopamine did not change S-100 immunoreactivity of uterine nerves...
- Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibersA Pertovaara
Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
Eur J Pharmacol 429:139-45. 2001..Following chemical sympathectomy with 6-hydroxydopamine, antinociception was achieved at a lower dose ipsilaterally, than contralaterally, ..
- Autoradiographic localization of vascular dopamine receptorsF Amenta
Dipartimento di Scienze Neurologiche, , Rome, Italy
Am J Hypertens 3:34S-36S. 1990..Moreover, 3H-SCH 23390 binding sites were not sensitive to chemical sympathectomy, suggesting postjunctional localization of DA-1 receptors...
- [Repeated percutaneous chemical sympathectomy as a therapeutic option for treating PAD II]P Gaus
Abteilung für Anästhesie und Intensivmedizin, Kliniken Dr Erler gGmbH, Kontumazgarten 4 18, 90429 Nürnberg, Deutschland
Schmerz 24:625-8. 2010..The case is an occasion to call for larger controlled studies designed to find out the efficacy of LSE for the treatment of stage II PAD. Mechanisms and available data are discussed...
- Radiation-induced brachial plexopathy in women treated for carcinoma of the breastEdward Fathers
Department of Neurology, Derriford Hospital, Plymouth, UK
Clin Rehabil 16:160-5. 2002..To study the clinical presentation and natural history of radiation-induced brachial plexopathy in 33 women treated for carcinoma of the breast...
- Autoradiographic localization of dopamine DA-2 receptor sites in rat mesenteric vascular treeA Ricci
Dipartimento di Scienze Neurologiche, Universita La Sapienza, Roma, Italy
J Pharmacol Exp Ther 254:750-5. 1990..In contrast, chemical sympathectomy was without effect on intimal [3H]spiroperidol binding sites...
- Neuropeptide tyrosine (NPY)-induced potentiation of the pressor activity of catecholamines in conscious ratsL F Lopez
Department of Physiology, Faculty of Biological Sciences, Catholic University, Santiago, Chile
Peptides 10:551-8. 1989..b>Chemical sympathectomy following 6-hydroxydopamine caused a marked supersensitivity to the catecholamines and NPY but obliterated ..
- A proposed role for nerve growth factor in the etiology of multiple sclerosisR C Olson
Med Hypotheses 51:493-8. 1998..They become more sensitive than controls to noradrenaline after chemical sympathectomy. Continued exposure to high noradrenaline can result in sympathectomy-like effects, heightening ..
- Mechanisms mediating circadian oscillations of leukocyte migrationPaul S Frenette; Fiscal Year: 2012..Furthermore, using chemical sympathectomy and surgical denervation, we have found that the fluctuations of leukocyte recruitment were abolished in ..
- The Role of the Autonomic Nervous System in HSV InfectionAndrea S Bertke; Fiscal Year: 2013..model in vitro, by reactivating autonomic neurons from latently infected mice ex vivo, and by using a chemical sympathectomy model in vivo to determine if pathway ablation alters infection and reactivation patterns;and 3) to ..
- MECHANISM OF TRH EFFECTS IN FETAL LUNG DEVELOPMENTUDAY DEVASKAR; Fiscal Year: 1999..TRH therapy in the HYT/HYT mouse with & without prior treatment with 6- hydroxydopamine (6-OHDA, chemical sympathectomy) or Propranolol (beta- adrenergic blockade) respectively: Absence of TRH effects on the lung in 6-OHDA or ..
- AUTONOMIC CONTROL OF LACRIMAL GLAND FUNCTIONBARRY BROMBERG; Fiscal Year: 1980..Parasympathectomy will be attempted by cauterization of the facial nerve. Chemical sympathectomy will be by systemic release of atropine from subcutaneous or intraperitoneal minipump or by direct ..
- SYSTEMIC AND LOCAL REGULATION OF MYOMETRIAL ACTIVITYJorge Figueroa; Fiscal Year: 1993..the role of the SAS in the initiation and/or modulation of ACTH induced parturition in sheep following chemical sympathectomy. Specific Aim 2: Study the effects of chemical sympathectomy in non-pregnant sheep on: in vivo response of ..
- BILE SECRETORY STUDIES IN THE TRANSPLANTED LIVERWilliam Meyers; Fiscal Year: 1993..Selective chemical sympathectomy caused a marked reduction in biliary cholesterol, phospholipi , and bile salt secretion during ..
- ANTI INFARCTION EFFECTS IN THE DENERVATED HEARTPATRICIA GWIRTZ; Fiscal Year: 1993..Four new studies are proposed: Study 10 will use conscious dogs and will examine whether chronic chemical sympathectomy [by topical application of phenol] exerts the same influence on the coronary collateral circulation as ..
- A CELL CYCLE STUDY OF DEVELOPING RAT SALIVARY GLANDSRobert Klein; Fiscal Year: 1980..sympatholytic, and parasympatholytic drugs as well as by actual surgical denervation procedures and chemical sympathectomy. The normal cell cycle curve of each of the major salivary glands will be used as a foundation upon which ..
- EXERCISE AND ANIMAL MODELS OF HYPERTENSIONCHARLES TIPTON; Fiscal Year: 1992..b>Chemical sympathectomy and central injections of "putative transmitters" will be used to determine changes in the functioning of ..
- INACTIVATION OF NOREPINEPHRINE IN VASCULAR TISSUEJEROME LEVIN; Fiscal Year: 1980..Standard regimens with 6-hydroxydopamine do not produce a good chemical sympathectomy in blood vessels...
- Effects of Maternal Diet on SNS Development in OffspringJames Young; Fiscal Year: 2009..Studies will examine effects of pharmacological interventions on the developing SNS, employing chemical sympathectomy in circumstances of increased SNS and neuroprotective agents in settings of decreased SNS, and assessing ..
- Cytokine and MAP Kinase Involvement in Neuropathic PainLinda Sorkin; Fiscal Year: 2008..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
- Chronic Alcohol & AIDS Impact on Muscle WastingPatricia Molina; Fiscal Year: 2006..abstract_text> ..
- RENAL ANGIOTENSIN II RECEPTOR AND SODIUM INTAKEDonna Wang; Fiscal Year: 2007..abstract_text> ..
- Ca permeable non-NMDAr: New spinal sensitization pathwayLinda Sorkin; Fiscal Year: 2005..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
- Annual Meeting of the American Pain SocietyLinda Sorkin; Fiscal Year: 2005..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
- ENVIRONMENTAL TEMPERATURE, SNS DEVELOPMENT AND OBESITYJames Young; Fiscal Year: 2005..The potential impact of changes in sympathetic activity regulated by RPa for glucose and energy metabolism will also be examined. ..
- Molecular Basis of D1 and D2 PrimingAlexia Pollack; Fiscal Year: 2003..Elucidation of this mechanism could lead to treatment strategies aimed to prevent these dyskinesias, which would, in turn, lengthen the time that dopamine replacement therapy is effective to treat patients with PD. ..
- EPIDERMAL GROWTH FACTOR, OBESITY & INSULIN RESISTANCEJames Young; Fiscal Year: 2001..A principal tenet of this proposal is that early life events which predispose animals to become obese differ from those which promote subsequent development in insulin resistance. ..
- BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSIONDavid Wirtshafter; Fiscal Year: 2003..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
- Cannabinoid effects on HIV/AIDSPatricia E Molina; Fiscal Year: 2010....
- Alcoholism and Disease: Immune /Pathological MechanismsPatricia Molina; Fiscal Year: 2002..The proceedings of these symposia will be published and a summary report to the NIAAA will be prepared. ..
- Molecular Sensing of Sodium Homeostasis: Anandamide RoleDonna Wang; Fiscal Year: 2009....
- IMPROVED CELL COUNTING USING THE OPTICAL DISECTORCHRISTOPHER VON BARTHELD; Fiscal Year: 2004....
- Lateral Hypothalamus, Dopamine and Ingestive BehaviorDavid Wirtshafter; Fiscal Year: 2007..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
- Estrogenic LXR Alpha Response /Cholesterol HomeostasisPhillip Kramer; Fiscal Year: 2003..abstract_text> ..
- WAGES: Workplace Activity for Employee Goal SettingRODNEY DISHMAN; Fiscal Year: 2006..The project will implement and rigorously evaluate a multilevel physical activity intervention that has potential for broad application to workplace health promotion. ..
- NEURAL MECHANISMS OF CYCLOSPORINE-INDUCED HYPERTENSIONRobert Augustyniak; Fiscal Year: 2003..abstract_text> ..
- PERINATAL HYPOXIA: ADRENOCORTICAL-METABOLIC ADAPTATIONSHershel Raff; Fiscal Year: 2006..Characterization of the hypothalamic-pituitary-adrenal and metabolic adaptations to perinatal hypoxia can lead to new diagnostic approaches and therapies to minimize morbidity and mortality. ..
- Estrogenic Regulation of Inflammation Related to TMJDPhillip Kramer; Fiscal Year: 2006..The function of estrogen receptors ER alpha and/or ER beta will be directly addressed pharmacologically (e.g., antiestrogen) and through mutation studies of the Fc gamma RIIIA promoter. ..
- Volatile Anesthetic Action in Vertebrate Locomotor SystemsSteven L Jinks; Fiscal Year: 2010..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..