Genomes and Genes
brain tissue transplantation
Summary: Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
Publications202 found, 100 shown here
- A multiple target neural transplantation strategy for Parkinson's diseaseArun Chander Ramachandran
Faculty of Medicine, Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
Rev Neurosci 13:243-56. 2002..A multiple target strategy may restore dopaminergic input to affected basal ganglia nuclei and improve outcomes of neural transplantation in Parkinson's disease...
- Neural transplantation for the treatment of Parkinson's diseaseAnders Bjorklund
Wallenberg Neuroscience Center, Section of Neurobiology, Lund University, Sweden
Lancet Neurol 2:437-45. 2003
- Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regionsCecilia Eriksson
Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Lund, Sweden
Exp Neurol 184:615-35. 2003....
- A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's diseaseC Warren Olanow
Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Ann Neurol 54:403-14. 2003..Fetal nigral transplantation currently cannot be recommended as a therapy for PD based on these results...
- Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's diseaseI Reuter
Academic Department of Neuroscience, Kings College Hospital, London, UK
J Neurol Neurosurg Psychiatry 79:948-51. 2008..The other patient did not improve clinically or radiologically. Our results indicate that striatal transplantation in HD may be beneficial but further studies are needed to confirm this...
- Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosisStefano Pluchino
Neuroimmunology Unit DIBIT, San Raffaele Hospital, Via Olgettina 58, 20132 Milano, Italy
Nature 422:688-94. 2003..Thus, adult neural precursor cells promote multifocal remyelination and functional recovery after intravenous or intrathecal injection in a chronic model of multiple sclerosis...
- Transplantation of embryonic dopamine neurons for severe Parkinson's diseaseC R Freed
Division of Clinical Pharmacology, University of Colorado School of Medicine, Denver 80262, USA
N Engl J Med 344:710-9. 2001..CONCLUSIONS: Human embryonic dopamine-neuron transplants survive in patients with severe Parkinson's disease and result in some clinical benefit in younger but not in older patients...
- Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's diseaseIvar Mendez
Dalhousie University and Queen Elizabeth II Health Science Center, Division of Neurosurgery and Neuroscience, Halifax, Canada
Brain 128:1498-510. 2005....
- Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up studyAnne Catherine Bachoud-Lévi
INSERM U 421, Faculte de Medecine, Creteil, France
Lancet Neurol 5:303-9. 2006..We undertook long-term follow-up of previously reported patients with the disease to ascertain the nature and extent of any secondary decline after grafting...
- Bilateral human fetal striatal transplantation in Huntington's diseaseR A Hauser
Department of Neurology, University of South Florida, Tampa, FL 33606, USA
Neurology 58:687-95. 2002..Transplanted striatal cells have been demonstrated to survive, grow, establish afferent and efferent connections, and improve behavioral signs in animal models of Huntington's disease (HD)...
- Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic strokeSoon Tae Lee
Stroke and Stem Cell Laboratory, Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Seoul, South Korea
Brain 131:616-29. 2008..In summary, early intravenous NSC injection displayed anti-inflammatory functionality that promoted neuroprotection, mainly by interrupting splenic inflammatory responses after ICH...
- The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the ratE L Lane
Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
Neurobiol Dis 22:334-45. 2006..In conclusion, robust and reproducible AIMs were evoked in rats with large grafts by blockade of monoamine reuptake. These AIMs may provide a new tool for assessing dyskinetic effects of neural grafting...
- Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesiaThomas Carlsson
Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC A11, 221 84, Lund, Sweden
Neurobiol Dis 21:657-68. 2006..The results indicate that graft-induced dyskinesias in PD patients may be linked to single, small graft deposits that provide an uneven, patchy reinnervation of the putamen...
- Clinical neurotransplantation: core assessment protocol rather than sham surgery as controlGerard J Boer
Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
Brain Res Bull 58:547-53. 2002..It is a challenge for the neuroscience community to develop CAPs for brain diseases that are eligible for neurotransplantation in the future...
- Medical terminations of pregnancy: a viable source of tissue for cell replacement therapy for neurodegenerative disordersC M Kelly
Brain Repair Group, School of Biosciences, Cardiff University, UK
Cell Transplant 20:503-13. 2011....
- Birth dating of midbrain dopamine neurons identifies A9 enriched tissue for transplantation into parkinsonian miceChristopher R Bye
Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria 3010, Australia
Exp Neurol 236:58-68. 2012..These findings demonstrate the importance of standardized methods to improve cell therapy for Parkinson's disease and have significant implications for the generation and selectivity of dopamine neurons from stem cell based sources...
- Neural transplantation in Huntington's disease: the NEST-UK donor tissue microbiological screening program and review of the literatureM Farrington
Clinical Microbiology and Public Health Laboratory, Health Protection Agency and Addenbrooke s Hospital, Cambridge, UK
Cell Transplant 15:279-94. 2006..This article therefore presents a comprehensive, logical yet pragmatic screening program that could be employed in any clinical studies that use human fetal tissue for neurotransplantation...
- Staging and preparation of human fetal striatal tissue for neural transplantation in Huntington's diseaseA E Rosser
School of Biosciences, Cardiff University, PO Box 911, Museum Av, Cardiff CF10 3US, Wales, UK
Cell Transplant 12:679-86. 2003....
- Towards a protocol for the preparation and delivery of striatal tissue for clinical trials of transplantation in Huntington's diseaseC Watts
MRC Cambridge Centre for Brain Repair, Department of Neurosurgery, University of Cambridge, UK
Cell Transplant 9:223-34. 2000..Strategies aimed at minimizing the variability of tissue preparation should reduce the variability of functional outcome of striatal transplantation observed in animal models of Huntington's disease...
- Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's diseaseC Watts
Academic Department of Neurosurgery, Addenbrooke s Hospital and the University of Cambridge, Cambridge, UK
Cell Transplant 12:697-704. 2003..Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible...
- Reestablishment of damaged adult motor pathways by grafted embryonic cortical neuronsAfsaneh Gaillard
Institut de Physiologie et Biologie Cellulaires, Universite de Poitiers, Centre National de la Recherche Scientifique CNRS, 40 Avenue du Recteur Pineau, Poitiers, F 86022, France
Nat Neurosci 10:1294-9. 2007..They suggest that there is an unsuspected potential for neural cell transplantation to promote reconstruction after brain injury...
- Improving the survival of grafted dopaminergic neurons: a review over current approachesP Brundin
Wallenberg Neuroscience Center, Department of Physiological Sciences, Lund University, Sweden
Cell Transplant 9:179-95. 2000..These recent advances provide hope for improved survival of transplanted neurons in patients with Parkinson's disease, reducing the need for human embryonic donor tissue and increasing the likelihood of a successful outcome...
- The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesiasWei Li Kuan
Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
Neurobiol Dis 25:594-608. 2007..These results suggest that an A9 dopaminergic neuron-enriched transplant may be the key to an effective PD cell replacement therapy through normalisation of the altered striatal expression of Cdk5/DARPP-32...
- Time of transplantation and cell preparation determine neural stem cell survival in a mouse model of Huntington's diseaseVerena Johann
Department of Neurology, University Hospital RWTH, Pauwelsstr 30, 52074 Aachen, Germany
Exp Brain Res 177:458-70. 2007....
- Improved survival of young donor age dopamine grafts in a rat model of Parkinson's diseaseE M Torres
Department of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff CF10 3US, UK
Neuroscience 146:1606-17. 2007..We consider the in vivo conditions which allow this differentiation to occur, and the implications for the future of clinical trials based on dopamine cell replacement therapy...
- Embryonic stem cell-derived neuronally committed precursor cells with reduced teratoma formation after transplantation into the lesioned adult mouse brainMarcel Dihné
Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Germany
Stem Cells 24:1458-66. 2006..Purified SENAs that were differentiated into immature but postmitotic neurons did not form tumors up to four months after syngeneic transplantation into the acutely degenerated striatum and showed robust survival...
- Cell transplantation in Parkinson's disease: problems and perspectivesLaura E Allan
Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden
Curr Opin Neurol 23:426-32. 2010..We also highlight the challenges which remain to be met in order for cell therapy to become clinically effective and safe...
- Dyskinesias and dopamine cell replacement in Parkinson's disease: a clinical perspectivePeter Hagell
Department of Nursing, Lund University, P O Box 157, SE 221 00 Lund, Sweden
Brain Res Bull 68:4-15. 2005..Available data are scarce but allow for hypotheses to be generated that could (and should) be addressed in experimental animals...
- Neural grafting in Parkinson's disease Problems and possibilitiesPatrik Brundin
Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
Prog Brain Res 184:265-94. 2010..Finally, we discuss future possibilities offered by stem cells as potential sources of dopamine neurons that can be used for transplantation in PD...
- Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projectionsLachlan Thompson
Wallenberg Neuroscience Center, Department of Experimental Medical Research, Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University, SE 221 84 Lund, Sweden
J Neurosci 25:6467-77. 2005....
- Graft-induced dyskinesias in Parkinson's disease: what is it all about?Roger A Barker
Brain Repair Centre and Department of Neurology, University of Cambridge, Cambridge CB2 0PY, UK
Cell Stem Cell 7:148-9. 2010..Recently in Science Translational Medicine, Politis et al. (2010) demonstrate that GIDs may originate from serotoninergic neurons that are cografted in these transplants...
- Neural grafting in Parkinson's disease unraveling the mechanisms underlying graft-induced dyskinesiaEmma L Lane
Welsh School of Pharmacy, Cardiff University, South Wales, UK
Prog Brain Res 184:295-309. 2010..Based on the available clinical and preclinical data we outline strategies to avoid GID in future clinical trials using fetal cell transplants or cell preparations derived from stem cells...
- Volume and differentiation of striatal grafts in rats: relationship to the number of cells implantedC Watts
MRC Cambridge Centre for Brain Repair, and the Department of Neurosurgery, University of Cambridge, UK
Cell Transplant 9:65-72. 2000..These results have important practical implications in determining the optimum number of LGE cells to implant and hence in the design of any surgical protocol for the clinical application of this technique...
- Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's diseaseC S Lee
Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, Canada
Brain 123:1365-79. 2000....
- A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesionsC Dirk Keene
Department of Pathology, Harborview Medical Center, University of Washington Medical Center, Seattle, 98104, USA
Acta Neuropathol 117:329-38. 2009..This report, for the first time, highlights the potential for graft overgrowth in a patient receiving fetal neural transplantation...
- Dopamine release from nigral transplants visualized in vivo in a Parkinson's patientP Piccini
MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Nat Neurosci 2:1137-40. 1999..Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief...
- How the brain repairs itself: new therapeutic strategies in inflammatory and degenerative CNS disordersGianvito Martino
Neuroimmunology Unit DIBIT and Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
Lancet Neurol 3:372-8. 2004....
- Striatal neural grafting improves cortical metabolism in Huntington's disease patientsVéronique Gaura
URA CEA CNRS 2210, 4 Place du General Leclerc, 91401 Orsay Cedex, France
Brain 127:65-72. 2004..Our results demonstrate the usefulness of PET measurements of brain glucose metabolism in understanding the effects of foetal grafts in patients with Huntington's disease...
- The morphological development of neurons derived from EGF- and FGF-2-driven human CNS precursors depends on their site of integration in the neonatal rat brainA E Rosser
Cambridge Centre for Brain Repair, Cambridge, UK
Eur J Neurosci 12:2405-13. 2000..This is important for the application of such cells in CNS repair strategies, in particular neural transplantation...
- FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrainLisa Maves
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
Development 129:3825-37. 2002..Taken together, our findings demonstrate a crucial role for FGF-mediated inter-rhombomere signaling in promoting early hindbrain patterning and underscore the significance of organizing centers in patterning the vertebrate neural plate...
- Oligodendrocyte progenitors are generated throughout the embryonic mouse brain, but differentiate in restricted fociR J Hardy
Brookdale Center for Molecular Biology, Mount Sinai Medical School, NY 10029, USA
Development 122:2059-69. 1996..By contrast, the differentiation of such cells into oligodendrocytes does occur in a restricted manner, consistent with local regulation of oligodendrocyte progenitor differentiation...
- Combined neurotrophic supplementation and caspase inhibition enhances survival of fetal hippocampal CA3 cell grafts in lesioned CA3 region of the aging hippocampusV Zaman
Medical Research Service, Veterans Affairs Medical Center, Durham, NC 27705, USA
Neuroscience 109:537-53. 2002..Thus, pre-treatment and grafting of donor cells with a combination of factors that support growth of specific donor cells may considerably enhance survival and integration of fetal grafts into the lesioned aging CNS in clinical trials...
- Normal host prion protein necessary for scrapie-induced neurotoxicityS Brandner
Department of Pathology, University Hospital, Zurich, Switzerland
Nature 379:339-43. 1996..Therefore, in addition to being resistant to scrapie infection, brain tissue devoid of PrPC is not damaged by exogenous PrPSc...
- Dyskinesias following neural transplantation in Parkinson's diseasePeter Hagell
Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
Nat Neurosci 5:627-8. 2002....
- Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington's disease patients after transplantationPasquale Gallina
Department of Neurosurgery, University of Florence, Florence, Italy
Exp Neurol 222:30-41. 2010..Further studies are necessary to assess the clinical efficacy of the human fetal striatal transplantation...
- Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475A E Rosser
School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
J Neurol Neurosurg Psychiatry 73:678-85. 2002..The authors report a safety study of unilateral transplantation of human fetal striatal tissue into the striatum of four patients with HD...
- Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian ratsEleonora Maries
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, N Chicago, IL 60064, USA
Neurobiol Dis 21:165-80. 2006..The onset of forelimb-facial stereotypy correlated with measures of increased graft function...
- Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantationT Ostenfeld
MRC Centre for Brain Repair, University of Cambridge, United Kingdom
Exp Neurol 164:215-26. 2000....
- Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's diseaseLars M Bjorklund
Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
Prog Brain Res 138:411-20. 2002
- Graft-mediated functional recovery on a skilled forelimb use paradigm in a rodent model of Parkinson's disease is dependent on reward contingencyKarina Kohn Cordeiro
Laboratory of Molecular Neurosurgery, Department of Stereotactic Neurosurgery, University Hospital Freiburg Neurocentre, Breisacher Str 64, D 79106 Freiburg, Germany
Behav Brain Res 212:187-95. 2010..Our results confirm that VM transplants can partially restore skilled forelimb sensorimotor deficits under specific testing configuration...
- Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?Curt R Freed
Departments of Medicine, Neurology, Psychiatry, and Neurosurgery Box, University of Colorado School of Medicine, 4200 East Ninth Avenue, C237, Denver, CO 80220, USA
J Neurol 250:III44-6. 2003..Neurotransplantation should be tried earlier in the clinical course of Parkinson's to see if earlier intervention can prevent progression of the disease, particularly the dyskinetic responses seen after longterm L-dopa treatment...
- Combination of bFGF, heparin and laminin induce the generation of dopaminergic neurons from rat neural stem cells both in vitro and in vivoYiqun Yu
Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 99 Shang Da Road, Shanghai 200444, China
J Neurol Sci 255:81-6. 2007..In this regard, we anticipated that this technology may advance stem cell-based therapy to replace lost neurons in neural injury or neurodegenerative disorders...
- Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhageSang Wuk Jeong
Department of Neurology, Ilsan Paik Hospital, Inje University, Ilsan, Korea
Stroke 34:2258-63. 2003..We hypothesize that intravenously transplanted human neural stem cells (NSCs) can migrate and differentiate into neurons or glial cells, thereby improving functional outcome in ICH...
- Transplantation of neurospheres after granule cell lesions in rats: cognitive improvements despite no long-term immunodetection of grafted cellsHélène Jeltsch
LN2C, UMR 7521, CNRS Université Louis Pasteur, 12 rue Goethe, F 67000, Strasbourg, France
Behav Brain Res 143:177-91. 2003....
- Interference with anoikis-induced cell death of dopamine neurons: implications for augmenting embryonic graft survival in a rat model of Parkinson's diseaseDeanna M Marchionini
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, 2422 West Harrison St, Chicago, Illinois 60612, USA
J Comp Neurol 464:172-9. 2003....
- Behavioral/neurophysiological investigation of effects of combining a quinolinic acid entopeduncular lesion with a fetal mesencephalic tissue transplant in striatum of the 6-OHDA hemilesioned ratM E Olds
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
Synapse 49:1-11. 2003....
- Both apoptosis and necrosis occur early after intracerebral grafting of ventral mesencephalic tissue: a role for protease activationM Emgard
Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Sweden
J Neurochem 86:1223-32. 2003..The present results imply that grafted cells may be victims of either an early necrotic or a later apoptotic cell death and that there is substantial cell death as early as 90 min after implantation...
- Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's diseaseHitoshi Yamada
Yokohama Neurology Clinic and School of Medicine, Yokohama City University, 1 211 1 Mutsukawa, Minami Ku, Yokohama 232 0066, Japan
Ann Neurol 54:352-9. 2003..VHL gene transduction provides a new therapeutic approach for treatment of PD...
- Dopaminergic neurons associate with blood vessels in neural transplantsDiana Casper
Department of Neurosurgery, Montefiore Medical Center and the Albert Einstein College of Medicine, New York, NY, USA
Exp Neurol 184:785-93. 2003..These patterns became more marked with time. Results suggest that rates and patterns of vascularization may be important determinants in the long-term survival of dopaminergic neurons...
- Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatumVladimer Darsalia
Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, University Hospital BMC B10, Klinikgatan 26, SE 221 84 Lund, Sweden
Eur J Neurosci 26:605-14. 2007..Based on these data, human fetal striatum- and cortex-derived NSCs could be considered potentially safe and viable for transplantation, with strong neurogenic potential, for further exploration in animal models of stroke...
- Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsyMuddanna S Rao
Department of Surgery Neurosurgery Duke University Medical Center, Durham, NC 27710, USA
Neurobiol Dis 27:117-32. 2007..In contrast, HFCs treated and grafted with BNC or FC survive robustly in the chronically epileptic hippocampus, considerably reduce the frequency of SRMS and blunt the progression of chronic TLE...
- Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's diseaseLucy Anderson
Centre for Brain Repair and Department of Clinical Neurosciences, University Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
Neurobiol Dis 27:133-40. 2007..This suggests that even in the absence of cell replacement strategies utilising immature progenitor cells could be of real therapeutic value...
- The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing diseaseNathalie Breysse
Central Nervous System Disease Modeling Unit, Section for Neuroscience, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden
J Neurosci 27:5849-56. 2007....
- Protection of dopamine neurons by bone marrow stromal cellsAki Shintani
Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan
Brain Res 1186:48-55. 2007..The present data indicate that BMSC may be a potential donor source of cell-based regenerative therapy for PD where the progressive loss of the midbrain DA neurons takes place...
- Pleiotrophin promotes functional recovery after neural transplantation in ratsHideki Hida
Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Neuroreport 18:179-83. 2007..Interestingly, the effect of pleiotrophin on the survival was additive to that of glial-cell line-derived neutropic factor. These results revealed that pleiotrophin had effects on donor cells in neural transplantation in vivo...
- Mesencephalic human neural progenitor cells transplanted into the neonatal hemiparkinsonian rat striatum differentiate into neurons and improve motor behaviourMarine Hovakimyan
Institute of Anatomy, Medical Faculty, University of Rostock, Germany
J Anat 209:721-32. 2006..To minimize donor tissue necessary for transplantation, further investigations will aim to enhance dopaminergic differentiation of transplanted cells in vivo...
- Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in cultureA E Donaldson
Farber Institute for Neurosciences, Thomas Jefferson University Medical College, Philadelphia, PA 19107, USA
Mol Cell Neurosci 30:108-17. 2005..We conclude that GFP-tagged DA neurons can be purified to homogeneity and can survive and function when grown with glial factors in vitro or after transplantation in vivo...
- Pig xenografts to the immunocompetent rat brain: Survival rates using distinct neurotoxic lesions in the nigrostriatal pathway and two rat strainsR Robichon
INSERM UPVM U 421, Plasticité cellulaire et thérapeutique, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil Cedex, France
Exp Neurol 194:333-40. 2005..We conclude that the distinct neurotoxins and host rat strains used in our experimental design are not major factors influencing the rejection time-course of primary neural xenografts...
- Implantation of pure cultured olfactory ensheathing cells in an animal model of parkinsonismD Dewar
Division of Clinical Neuroscience, Wellcome Surgical Institute, Beatson Labs, Garscube Estate, University of Glasgow, Glasgow, UK
Acta Neurochir (Wien) 149:407-14. 2007..In the present study we have examined the potential of olfactory ensheathing cells (OEC) to promote brain repair after surgical implantation in a rodent model of parkinsonism...
- Fate of cloned embryonic neuroectodermal cells implanted into the adult, newborn and embryonic forebrainK Demeter
Institute of Experimental Medicine of Hung Acad Sci, Budapest, Hungary
Exp Neurol 188:254-67. 2004..The data suggest that noncommitted, proliferating neuroectodermal progenitors can integrate into the brain tissue at time and site of tissue genesis...
- Comparison of embryonic stem cell-derived dopamine neuron grafts and fetal ventral mesencephalic tissue grafts: morphology and functionDavid M Yurek
Department of Surgery Neurosurgery, University of Kentucky College of Medicine, Lexington, KY 40536 0305, USA
Cell Transplant 13:295-306. 2004..These data suggest there are similarities and also distinct differences in the manner in which ESC and VM grafts interact with the denervated striatum...
- Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoformsMarco Timmer
Department of Neuroanatomy, Center of Anatomy, OE 4140, Hannover Medical School, D 30623 Hannover, Germany
Exp Neurol 187:118-36. 2004..We propose that administration of HMW FGF-2 may be used to improve function in the rat Parkinson's disease model...
- An in vitro interval before transplantation of mesencephalic reaggregates does not compromise survival or functionalityCaryl E Sortwell
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Exp Neurol 187:58-64. 2004..This ex vivo reaggregate system allows for extended pretreatment (3 days) of mesencephalic cells with survival-promoting agents and immunological screening of tissue before transplantation...
- The future of cell-based transplantation therapies for neurodegenerative disordersStanley E Lazic
Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK
J Hematother Stem Cell Res 12:635-42. 2003..Finally we will discuss the prospect of using stem cells to deliver drugs and neurotrophic factors involved in neuroprotective and neuroreparative strategies in Parkinson's disease and other neurodegenerative conditions...
- Comparison of pure and mixed populations of human fetal-derived neural progenitors transplanted into intact adult rat brainDarin J Messina
Program in Neuroscience, The Keck Center for Tissue Engineering, University of Utah, Salt Lake City, UT 84112, USA
Exp Neurol 184:816-29. 2003....
- Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neuronsBrian T Terpstra
Department of Neurology, University of Cincinnati, PO Box 670525, Cincinnati, OH 45267 0525, United States
J Neurosci Methods 166:13-9. 2007..These data have the potential to identify optimal transplantation parameters that can be applied to procedures utilizing stem cells, neural progenitors, and primary mesencephalic cells...
- [Effects of simultaneous transplant of foetal mesencephalic cells in the striatum and the subthalamic nucleus of hemiparkinsonian rats]N Pavón-Fuentes
Centro Internacional de Restauracion Neurologica CIREN, La Habana, 11300, Cuba
Rev Neurol 34:917-23. 2002..A series of data from pharmacological and physiological studies offer strong evidence that the dopamine released in these nuclei may play an important role in regulating the output nuclei of the basal ganglia...
- Induction of tyrosine hydroxylase expression in rat fetal striatal precursor cells following transplantationZhongshu Tang
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, 200031, PR China
Neurosci Lett 324:13-6. 2002..The results further exemplify the potential of neural stem cells and the property of site-specific differentiation when the cells were transplanted to the dopaminergic system of the adult brain...
- Morphological changes in immunopositive cells of ionotropic glutamate receptor subunits during the development of transplanted fetal ventral mesencephalic neuronsYasushi Ishida
Department of Psychiatry, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki gun, 889 1692, Miyazaki, Japan
Brain Res 940:79-85. 2002..These results suggest that the ionotropic glutamate receptors have differential roles during the developmental period of the intrastriatal VM grafts...
- Cellular replacement therapy for Parkinson's disease--where we are today?D Eugene Redmond
Department of Psychiatry, Yale University School of Medicine, USA
Neuroscientist 8:457-88. 2002..New sources of replacement cells and stem cells may provide additional advantages for the future. Full recovery from parkinsonism appears not only to be possible, but a reliable cell replacement treatment may finally be near...
- IL-1 beta is released from the host brain following transplantation but does not compromise embryonic dopaminergic neuron survivalDeborah J Clarke
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, OX1 3QX, Oxford, UK
Brain Res 952:78-85. 2002..Modulation of IL-1 beta activity, therefore, will not offer significant improvements to neural transplantation as a treatment for PD...
- The controlled conversion of human neural progenitor cells derived from foetal ventral mesencephalon into dopaminergic neurons in vitroSamina S Riaz
Department of Biochemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, South Kensington, London, SW7 2AY, UK
Brain Res Dev Brain Res 136:27-34. 2002....
- Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activationC B Hurelbrink
Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
Exp Neurol 171:46-58. 2001..This implies that strategies to improve dopaminergic cell survival in clinical programmes of transplantation for PD will need to target other pathways of cell death...
- Engraftment of sorted/expanded human central nervous system stem cells from fetal brainStanley Tamaki
StemCells, Inc, Palo Alto, California
J Neurosci Res 69:976-86. 2002..Thus, marking human CNS-SC with reporter genes introduced by lentiviral vectors is a useful tool with which to characterize migration and differentiation of human cells in this mouse transplantation model...
- Immunohistochemical and electron microscopic study of invasion and differentiation in spinal cord lesion of neural stem cells grafted through cerebrospinal fluid in ratSufan Wu
Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
J Neurosci Res 69:940-5. 2002....
- Additive effect of glial cell line-derived neurotrophic factor and neurotrophin-4/5 on rat fetal nigral explant culturesM Meyer
Department of Neurosurgery, University of Bern, Inselspital, Bern, Switzerland
Neuroscience 108:273-84. 2001..These results indicate that combined treatment with GDNF and NT4/5 may be beneficial for embryonic nigral donor tissue either prior to, or in conjunction with, intrastriatal transplantation in Parkinson's disease...
- Astrocytes from cerebral cortex or striatum attract adult host serotoninergic axons into intrastriatal ventral mesencephalic co-graftsA Petit
, , , , , Canada H3C 3J7
J Neurosci 21:7182-93. 2001..It should now be feasible to identify the molecules expressed by cultured cortical or striatal, but not by ventral mesencephalic, astrocytes that have these tropic actions on 5-HT axons of the neostriatum...
- Neuroscience. Versatile cells against intractable diseasesConstance Holden
Science 297:500-2. 2002
- A sequential intrastriatal dopaminergic graft strategy in the rodent model for Parkinson's disease: implications for graft survival and targetingK A Baker
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
Cell Transplant 11:185-93. 2002..These results are further discussed in relation to their important clinical implication for neural transplantation in PD...
- A role for tumor necrosis factor alpha in death of dopaminergic neurons following neural transplantationDeborah J Clarke
Department of Human Anatomy and Genetics, South Parks Road, Oxford, United Kingdom
Exp Neurol 176:154-62. 2002..Use of this therapeutic antibody approach may offer significant improvements to neural transplantation as a treatment for PD...
- Combined inhibition of apoptosis and complement improves neural graft survival of embryonic rat and porcine mesencephalon in the rat brainF Cicchetti
Neuroregeneration Laboratories, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
Exp Neurol 177:376-84. 2002..These studies indicate that more than one mechanism can mediate cell death during neural cell transplantation and that a combined treatment using caspase and complement inhibition can significantly improve cell survival...
- Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projectionsUlrica Englund
Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, S 221 84 Lund, Sweden
Exp Neurol 173:1-21. 2002..The extensive integration and differentiation of in vitro-expanded human neural progenitor cells indicate that multipotent progenitors are capable of responding in a regionally specific manner to cues present in the developing rat brain...
- Neural stem cells and Parkinson's diseaseAlexander Storch
Department of Neurology, University of Ulm, 89081 Ulm, Germany
J Neurol 249:III/30-2. 2002..These cells will hopefully enable restorative treatment of patients with Parkinson's disease in the near future...
- Current state of stem cell research for the treatment of Parkinson's diseaseM Gerlach
Klinische Neurochemie, Universitätsklinik für Kinder und Jugendpsychiatrie und Psychotherapie, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
J Neurol 249:III/33-5. 2002..The problem is controlling cell growth and differentiation. We will briefly review the current state of stem cell research and will critically discuss the potential of stem cells for the treatment of PD...
- Fetal striatal transplants restore electrophysiological sensitivity to dopamine in the lesioned striatum of rats with experimental Huntington's diseaseGuann Juh Chen
Department of Neurological Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
J Biomed Sci 9:303-10. 2002..In conclusion, our data demonstrate that fetal striatal transplants restore electrophysiological sensitivity to DA in the lesioned striatum of animals with experimental HD...
- Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brainCecilia Lundberg
Wallenberg Neuroscience Center, Lund University, S 221 84, Sweden
Exp Neurol 175:370-87. 2002....
- Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgeneK Sawamoto
Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
J Neurosci 21:3895-903. 2001..Together, these findings indicate that precursor cells harvested from the embryonic ventral mesencephalon can generate dopaminergic neurons able to restore function to the chemically denervated adult striatum...
- Diminished survival of mesencephalic dopamine neurons grafted into aged hosts occurs during the immediate postgrafting intervalC E Sortwell
Department of Neurological Sciences, Research Center for Brain Repair, Rush-Presbyterian-St. Luke's Medical Center, Suite 200, 2242 West Harrison Street, Chicago, Illinois, 60612, USA
Exp Neurol 169:23-9. 2001....
- Retinal integration of grafts of brain-derived precursor cell lines implanted subretinally into adult, normal ratsK Warfvinge
Wallenberg Retina Center, Lund University Hospital, Lund, Sweden
Exp Neurol 169:1-12. 2001..Our results suggest that these and other similar neural cell lines could be very useful in the continuous experiments in models of retinal disorders to further assess both the cell replacement and ex vivo gene therapy approaches...
- N-acetylcysteine enhances production of dopaminergic neurons from mesencephalic-derived precursor cellsJ Rodriguez-Pallares
Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Neuroreport 12:3935-8. 2001..The results suggest that NAC is effective in the production of DA cells from precursors, and that this may be related to enhancement of generation and/or survival of DA cells...
- Trophic support of mouse inner ear by neural stem cell transplantationFukuichiro Iguchi
Department of Otolaryngology Head and Neck Surgery, Kyoto University Graduate School of Medicine, Japan
Neuroreport 14:77-80. 2003..These findings indicate that transplantation of neural stem cells can be a useful strategy for application of neurotrophins in inner ear...
- Enhancement of IRB Education & TechnologyJOHN SLADEK; Fiscal Year: 2003..We believe this comprehensive program will provide our institution with a higher level of quality, investigator participation and efficiency in review and oversight of human subject research. ..
- BRAIN TISSUE TRANSPLANTATION--FUNCTIONAL ACTIVITYJill Becker; Fiscal Year: 1990....
- Behavior of Stem Cells in the Lesioned Aging HippocampusAshok Shetty; Fiscal Year: 2006..abstract_text> ..
- Repair of Chronially Injured Hippocampus by GraftsAshok Shetty; Fiscal Year: 2006..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
- Improving neural graft function in parkinsonian monkeys.DONALD REDMOND; Fiscal Year: 2007..abstract_text> ..
- HUMAN NEURAL STEM CELLS IN PRIMATE PARKINSON'S MODELDONALD REDMOND; Fiscal Year: 2004..The results will also advance understanding of useful methods for studying and treating a broad range of neurodegenerative, genetic, and traumatic conditions of the nervous system. ..
- GDNF Delivery to MPTP Monkeys by EIAV lentivirus and AAVDONALD REDMOND; Fiscal Year: 2008..These studies aim to provide the necessary data to initiate successful clinical trials in Parkinson's patients at the earliest possible time. ..
- EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISMCurt Freed; Fiscal Year: 2005..Brains will be stained with H+E and immunostained for tyrosine hydroxylase and B and T cell markers. Stereologically corrected counts of TH-positive neurons will be determined. ..
- Gene Therapy, Neural Grafts & Parkinson's DiseaseDAVID YUREK; Fiscal Year: 2005..These studies will also determine if combinations of viral vectors expressing different neurotrophic factors can be used to improve the therapeutic effects of dopamine grafts. ..
- Stem Cell Adaptability in Parkinson' DiseaseDAVID YUREK; Fiscal Year: 2009..The variable of host age on ESC-derived dopamine neuron adaptability will be studied. ..
- DOUBLE-BLIND CONTROLLED TRIAL OF NIGRAL GRAFTING IN PDC Olanow; Fiscal Year: 2003..abstract_text> ..
- Investigation of the Placebo Effect in a Longitudinal Double-Blind Surgical TrialCynthia McRae; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Marrow stromal cell deliver to repair the spinal cordJeffery Kocsis; Fiscal Year: 2007..abstract_text> ..
- Experience modulates brain plasticity in adult primatesYevgenia Kozorovitskiy; Fiscal Year: 2007..unreadable] [unreadable]..
- DYSKINESIAS IN LENTI-GDNF TREATED PARKINSONIAN MONKEYSJeffrey Kordower; Fiscal Year: 2006..This application will determine whether potent dopaminergic gene therapies influence dyskinesias in the best animal model of PD. ..
- An animal model for age-related degenerationANN CHARLOTTE ESTHER GRANHOLM; Fiscal Year: 2010..The overall purpose of these studies is to investigate endogenous defense mechanisms as well as the degenerative process in itself, to explore if early intervention strategies can be employed. ..
- Analgesic effects of adrenal chromaffin cell transplantsGeorge Pappas; Fiscal Year: 2007..abstract_text> ..
- Evaluating Striatal Function in a Murine HD ModelRoger Albin; Fiscal Year: 2007..Validation of these methods will provide new and useful behavioral tools for evaluating murine disease models. [unreadable] [unreadable] [unreadable]..
- Stem cell-mediated delivery of neurotrophic factors for treatment of glaucomaDonald S Sakaguchi; Fiscal Year: 2010..Furthermore, these cells can survive in the environment of the eye and have the ability to integrate within the inner retina to serve as delivery vehicles for therapeutic proteins. ..
- Beneficial Effects of Blueberries on Neural TransplantsLauren Willis; Fiscal Year: 2007..In addition, these experiments focus on nutritional intervention in improving survival of transplanted neural tissue to a middle-aged host animal, a new focus in the field of aging and alternative medicine. ..
- Regulatable Gene Transfer for Spinal Cord InjuryArmin Blesch; Fiscal Year: 2010..If successful, these studies will establish practical strategies for growth factor delivery to the injured spinal cord that can lead to the development of novel therapies for spinal cord injury. ..
- Mechanisms of neurotrophin-improved cognition in agingANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2007..abstract_text> ..
- Reconstruction of nigrostriatal pathway by photopolymerized neurotrophin...Kimberly Bjugstad; Fiscal Year: 2008..While we are using an animal model of PD to test this hypothesis, if successful, it could have implications for other neurodegenerative disorders, including Huntington's Disease or stroke. [unreadable] [unreadable] [unreadable]..
- TH and GTPCHI gene therapy for Parkinson's diseaseJeffrey H Kordower; Fiscal Year: 2010..These studies will determine the safety and efficacy of gene delivery of LDOPA and determine whether this approach is appropriate for clinical trials. ..
- Lifespan Metabolic Neuroprotection during HypoglycemiaDennis Turner; Fiscal Year: 2008..unreadable] [unreadable]..
- Aberrant Synaptic Plasticity: Impact of Dopamine on Graft OutcomeKathy Steece Collier; Fiscal Year: 2008..abstract_text> ..
- Effect of AADC gene transfer on L-dopa induced dyskinesia in MPTP monkeysRobert Richardson; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Olig 2 Lineage Cells Derived From ES CellsDavid Gottlieb; Fiscal Year: 2008..One strong possibility is that genetically engineered cells will be most efficacious in transplantation. The ES cell-based system is ideally suited to providing genetically engineered cells. ..
- International meeting Neural Transplantation and RepairANN CHARLOTTE GRANHOLM BENTLEY; Fiscal Year: 2002..In addition, previous statistics demonstrate that we have favored women and minorities in the past (33% of the travel award recipients for this years' meeting were women, and women serve on all the committees in our organization). ..
- MURINE MODEL OF CAG REPEAT DISEASESRoger Albin; Fiscal Year: 2002..These experiments will establish HPRT-CAG mice as important tools for understanding neurodegeneration in CAG repeat diseases and enable accurate preclinical evaluation of interventions for CAG repeat diseases. ..
- TRANSGENIC XENOTRANSPLANTS FOR HUNTINGTON'S DISEASEOle Isacson; Fiscal Year: 2002..These experiments will improve our knowledge of basal ganglia function and plasticity, as well as determine parameters for optimal cell transplantation in patients with neurological disease. ..
- Lifespan Neuronal/Glial Metabolism During HypoglycemiaDennis Turner; Fiscal Year: 2003..These in vitro slice models of hypoglycemia will contribute greatly to the understanding of neuronal metabolism, and particularly the metabolic interactions between neurons and glia as a function of lifespan. ..
- Evaluation of Stem Cell Plasticity In VivoGraca Almeida Porada; Fiscal Year: 2004..With these studies we hope to provide novel insights into the location of latent stem cell poois within the body and define the behavior and capabilities of these cells that are potentially of great clinical value. ..
- American Society for Neural Transplantation and RepairCaryl Sortwell; Fiscal Year: 2004..This application requests $15,000 in total direct costs to support travel awards for the top 15 graduate students/postdocs from US institutions that apply (awards of $1000 per student/postdoc). ..
- Regulatable Gene Therapy for Axonal RegenerationArmin Blesch; Fiscal Year: 2005..Further, this could lead to the development of therapies for clinical translation. ..
- American Society for Neural Transplantation and RepairCaryl Sortwell; Fiscal Year: 2005..This application requests $15,000 in total direct costs to support travel awards for the top 15 graduate students/postdocs from US institutions that apply (awards of $1000 per student/postdoc). ..
- Validation of rat models for resistant epilepsy therapyWolfgang Loscher; Fiscal Year: 2005..Our goal is to establish standard assays that can be employed by researchers to continue the search for treatments of drug resistant epilepsy. ..
- Demyelination Plus Transplantation to Study CNS RepairHans Keirstead; Fiscal Year: 2006..abstract_text> ..
- RECOVERY OF FUNCTION AFTER SPINAL CORD DAMAGEMarion Murray; Fiscal Year: 2005..abstract_text> ..
- In Utero Stem Cell Transplantation for Hemophilia AGraca Almeida Porada; Fiscal Year: 2006..abstract_text> ..
- Angiogenic Enhancement of Dopamine Neuron GraftsCaryl Sortwell; Fiscal Year: 2003..This strategy will be evaluated using primary mesencephalic tissue. However, results from these studies will be applicable to alternative sources of DA neurons, including stem- and progenitor-derived cells. ..
- American Society for Neural Therapy and RepairCaryl Sortwell; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Neuronal and Circuitry Mechanisms of Epileptogenesis in a Complex in Vitro ModelDennis Turner; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ANTI-INFLAMMATORY THERAPIES NEUROTOXICALLY INDUCED PDOle Isacson; Fiscal Year: 2004..Protection of the dopaminergic system by anti-inflammatory agents would be of tremendous therapeutic value for PD. ..
- Stem Cell Therapy for Motoneuron DegenerationPing Wu; Fiscal Year: 2006..abstract_text> ..
- Evaluation of Hypoxia in Grafted Dopamine NeuronsCaryl Sortwell; Fiscal Year: 2005..abstract_text> ..
- ETHANOL EFFECTS ON NEUROTRANSMISSIONFulton Crews; Fiscal Year: 2009..abstract_text> ..
- 9th Internatl Meeting on Neural Transplantation & RepairJOHN SLADEK; Fiscal Year: 2005..Thus, it will provide easier access to a large audience of scientists who may not have been able to attend the prior meetings because of geographical limitations. ..