lymph node excision

Summary

Summary: Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)

Top Publications

  1. ncbi Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction
    J S Macdonald
    St Vincent's Comprehensive Cancer Center, New York, USA
    N Engl J Med 345:725-30. 2001
  2. ncbi Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial
    Ilfet Songun
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Lancet Oncol 11:439-49. 2010
  3. ncbi Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial
    Jeeyun Lee
    Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam gu, Seoul 135 710 Korea
    J Clin Oncol 30:268-73. 2012
  4. ncbi Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089
    T E Le Voyer
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 21:2912-9. 2003
  5. pmc Gastric adenocarcinoma: review and considerations for future directions
    Bryan J Dicken
    Department of Surgery, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada
    Ann Surg 241:27-39. 2005
  6. ncbi Advantages of totally laparoscopic distal gastrectomy over laparoscopically assisted distal gastrectomy for gastric cancer
    Osamu Ikeda
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Notame 3 1 1, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Endosc 23:2374-9. 2009
  7. ncbi A prospective randomized study comparing open vs laparoscopy-assisted distal gastrectomy in early gastric cancer: early results
    J H Lee
    Department of Surgery, Ewha Woman s University College of Medicine, Seoul, Korea
    Surg Endosc 19:168-73. 2005
  8. ncbi A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer
    Umberto Veronesi
    Division of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 349:546-53. 2003
  9. ncbi A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy
    Kimberly J Van Zee
    Departments of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg Oncol 10:1140-51. 2003
  10. ncbi Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials
    Marie Overgaard
    Department of Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 82:247-53. 2007

Research Grants

Detail Information

Publications300 found, 100 shown here

  1. ncbi Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction
    J S Macdonald
    St Vincent's Comprehensive Cancer Center, New York, USA
    N Engl J Med 345:725-30. 2001
    ..CONCLUSIONS: Postoperative chemoradiotherapy should be considered for all patients at high risk for recurrence of adenocarcinoma of the stomach or gastroesophageal junction who have undergone curative resection...
  2. ncbi Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial
    Ilfet Songun
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Lancet Oncol 11:439-49. 2010
    ..The aim of the study was to assess the effect of D2 compared with D1 surgery on disease recurrence and survival in patients treated with curative intent...
  3. ncbi Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial
    Jeeyun Lee
    Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong Kangnam gu, Seoul 135 710 Korea
    J Clin Oncol 30:268-73. 2012
    ..This trial was designed to compare postoperative treatment with capecitabine plus cisplatin (XP) versus XP plus radiotherapy with capecitabine (XP/XRT/XP)...
  4. ncbi Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089
    T E Le Voyer
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 21:2912-9. 2003
    ..To determine the relationship, in patients with adenocarcinoma of the colon, between survival and the number of lymph nodes analyzed from surgical specimens...
  5. pmc Gastric adenocarcinoma: review and considerations for future directions
    Bryan J Dicken
    Department of Surgery, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada
    Ann Surg 241:27-39. 2005
    ..We provide the relevance of outcome data to surgical decision-making and discuss the application of gene-expression analysis to clinical practice...
  6. ncbi Advantages of totally laparoscopic distal gastrectomy over laparoscopically assisted distal gastrectomy for gastric cancer
    Osamu Ikeda
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Notame 3 1 1, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Endosc 23:2374-9. 2009
    ..Although laparoscopically assisted distal gastrectomy (LADG) has several advantages over open distal gastrectomy, little has been reported about the safety and feasibility of totally laparoscopic distal gastrectomy (TLDG)...
  7. ncbi A prospective randomized study comparing open vs laparoscopy-assisted distal gastrectomy in early gastric cancer: early results
    J H Lee
    Department of Surgery, Ewha Woman s University College of Medicine, Seoul, Korea
    Surg Endosc 19:168-73. 2005
    ..We conducted a prospective randomized trial to compare laparoscopy-assisted distal gastrectomy (LADG) including lymphadenectomy with open distal gastrectomy for the management of early gastric cancer (EGC)...
  8. ncbi A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer
    Umberto Veronesi
    Division of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 349:546-53. 2003
    ..Although numerous studies have shown that the status of the sentinel node is an accurate predictor of the status of the axillary nodes in breast cancer, the efficacy and safety of sentinel-node biopsy require validation...
  9. ncbi A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy
    Kimberly J Van Zee
    Departments of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg Oncol 10:1140-51. 2003
    ..Accurate estimates of the likelihood of additional disease in the axilla could assist greatly in decision-making regarding further treatment...
  10. ncbi Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials
    Marie Overgaard
    Department of Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 82:247-53. 2007
    ..A subgroup analysis of the DBCG 82 b&c trials was performed to evaluate the loco-regional recurrence rate and survival in relation to number of positive nodes...
  11. ncbi Nodal dissection for patients with gastric cancer: a randomised controlled trial
    Chew Wun Wu
    Department of Surgery, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Lancet Oncol 7:309-15. 2006
    ..We aimed to do a single-institution randomised trial to compare D1 (ie, level 1) lymphadenectomy with that of D3 (ie, levels 1, 2, and 3) dissection for gastric cancer in terms of overall survival and disease-free survival...
  12. pmc Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Surgical Co-operative Group
    A Cuschieri
    University Department of Surgery, Ninewells Hospital and Medical School, Dundee, UK
    Br J Cancer 79:1522-30. 1999
    ..However, the possibility that D2 resection without pancreatico-splenectomy may be better than standard D1 resection cannot be dismissed by the results of this trial...
  13. ncbi Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer
    Anne Fleissig
    Cancer Research UK Psychosocial Oncology Group, Brighton and Sussex Medical School, Falmer, UK
    Breast Cancer Res Treat 95:279-93. 2006
    ..001) and greater levels of anxiety (p < 0.01). In view of the benefits regarding arm functioning and quality of life, the data from this randomised study support the use of SNB in patients with clinically node negative breast cancer...
  14. ncbi Lymphatic mapping and sentinel lymph node biopsy in early-stage breast carcinoma: a metaanalysis
    Theodore Kim
    Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts, USA
    Cancer 106:4-16. 2006
    ..Lymphatic mapping with sentinel lymph node biopsy has the potential for reducing the morbidity associated with breast carcinoma staging. It has become a widely used technology despite limited data from controlled clinical trials...
  15. ncbi Is there a benefit of pretreatment laparoscopic transperitoneal surgical staging in patients with advanced cervical cancer?
    Simone Marnitz
    Department of Radiooncology, Charite Universitaetsmedizin, Berlin, Germany
    Gynecol Oncol 99:536-44. 2005
    ..The aim of this study is to describe the laparoscopic transperitoneal staging procedure in patients with cervical cancer and their oncologic outcome after primary chemoradiation...
  16. ncbi D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer
    Mitsuru Sasako
    Gastric Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    N Engl J Med 359:453-62. 2008
    ..We conducted a randomized, controlled trial at 24 hospitals in Japan to compare D2 lymphadenectomy alone with D2 lymphadenectomy plus PAND in patients undergoing gastrectomy for curable gastric cancer...
  17. ncbi Sentinel-node biopsy or nodal observation in melanoma
    Donald L Morton
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    N Engl J Med 355:1307-17. 2006
    ..We evaluated the contribution of sentinel-node biopsy to outcomes in patients with newly diagnosed melanoma...
  18. pmc The ratio between metastatic and examined lymph nodes (N ratio) is an independent prognostic factor in gastric cancer regardless of the type of lymphadenectomy: results from an Italian multicentric study in 1853 patients
    Alberto Marchet
    Clinica Chirurgica Generale 2, University of Padova, Padova, Italy
    Ann Surg 245:543-52. 2007
    ....
  19. pmc Risk factors for lymphedema after breast cancer treatment
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 19:2734-46. 2010
    ..As cancer treatments evolve, it is important to reevaluate their effect on lymphedema risk in breast cancer survivors...
  20. ncbi American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer
    Gary H Lyman
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Clin Oncol 23:7703-20. 2005
    ..To develop a guideline for the use of sentinel node biopsy (SNB) in early stage breast cancer...
  21. pmc Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection
    Takamaru Ashikaga
    University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Surg Oncol 102:111-8. 2010
    ....
  22. ncbi Meta-analysis of D1 versus D2 gastrectomy for gastric adenocarcinoma
    Muhammed Ashraf Memon
    Department of Surgery, Ipswich Hospital, Ipswich, Queensland, Australia
    Ann Surg 253:900-11. 2011
    ..To conduct a meta-analysis of randomized controlled trials evaluating the efficacy and drawbacks of limited (D1) versus extended lymphadenectomy (D2) for proven gastric adenocarcinoma...
  23. pmc Current management and future strategies of gastric cancer
    Joong Ho Lee
    Department of Surgery, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 53:248-57. 2012
    ....
  24. pmc Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall
    Xu Yong Lin
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang 110001, China
    Diagn Pathol 7:174. 2012
    ....
  25. ncbi Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomized Dutch gastric cancer group trial
    H H Hartgrink
    Department of Surgery, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 22:2069-77. 2004
    ..We have reviewed the results of our trial after follow-up of more than 10 years...
  26. ncbi Breast cancer related lymphedema in patients with different loco-regional treatments
    Beyza Ozcinar
    Istanbul University, Istanbul Medical Faculty, General Surgery Department, Istanbul, Turkey
    Breast 21:361-5. 2012
    ..Aim of this prospective observational study was to determine the rate of mid-term and late time period lymphedema in breast cancer patients with different loco-regional treatments, and factors associated with lymphedema...
  27. ncbi Combined axillary reverse mapping (ARM) technique for breast cancer patients requiring axillary dissection
    Claude Nos
    Department of Gynecologic and Oncologic Surgery, Hopital Europeen Georges Pompidou, 12 Rue Leblanc, 75015, Paris, France
    Ann Surg Oncol 15:2550-5. 2008
    ..The objective of axillary reverse mapping (ARM) is to preserve the main lymphatic chain-with both the nodes and the ducts-in relation to lymphatic arm drainage (LAD) during an axillary dissection (AD)...
  28. ncbi Laparoscopic assisted distal gastrectomy for early gastric cancer: is it an alternative to the open approach?
    Danny Yakoub
    Department of Biosurgery and Surgical Technology, Imperial College London, St Mary s Hospital, London, UK
    Surg Oncol 18:322-33. 2009
    ..This study aims to compare short term outcomes and oncological value of laparoscopy assisted (LADG) and open distal gastrectomy (ODG) in the treatment of early gastric cancer...
  29. ncbi Pattern of lymph node metastases of esophageal squamous cell carcinoma based on the anatomical lymphatic drainage system
    Y Tachimori
    Esophageal Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Dis Esophagus 24:33-8. 2011
    ....
  30. ncbi Safety and feasibility of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a multicenter phase II trial (JCOG 0703)
    Hitoshi Katai
    National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Gastric Cancer 13:238-44. 2010
    ..We conducted a multi-institutional phase II trial to evaluate the safety of LADG with nodal dissection for clinical stage I gastric cancer patients...
  31. ncbi Number of metastatic lymph nodes, but not lymph node ratio, is an independent prognostic factor after resection of pancreatic carcinoma
    Yoshiaki Murakami
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Am Coll Surg 211:196-204. 2010
    ..This study evaluated the prognostic significance of the number of metastatic lymph nodes and the ratio of metastatic nodes to total number of examined lymph nodes (lymph node ratio, LNR) after resection of pancreatic carcinoma...
  32. ncbi Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer: a case-control study
    Marco Scatizzi
    General Surgery Unit, Ospedale Misericordia e Dolce, Piazza dell Ospedale, Prato, PO, Italy
    Updates Surg 63:17-23. 2011
    ....
  33. ncbi The effect of spleen-preserving lymphadenectomy on surgical outcomes of locally advanced proximal gastric cancer
    Sung Jin Oh
    Department of Surgery, Yonsei University College of Medicine, Seodaemun gu, Seoul, South Korea
    J Surg Oncol 99:275-80. 2009
    ..The aim of this study was to investigate the effects of D2 lymphadenectomy with spleen preservation on surgical outcomes in locally advanced proximal gastric cancer...
  34. ncbi Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma
    C L Creutzberg
    Department of Radiation Oncology, University Hospital Rotterdam Daniel den Hoed Cancer Center, The Netherlands
    Lancet 355:1404-11. 2000
    ..We did a multicentre prospective randomised trial to find whether postoperative pelvic radiotherapy improves locoregional control and survival for patients with stage-1 endometrial carcinoma...
  35. ncbi Radical vaginal trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer-cumulative pregnancy rate in a series of 123 women
    J H Shepherd
    The Gynaecological Cancer Centre, St Bartholomew s Hospital, West Smithfield, London, UK
    BJOG 113:719-24. 2006
    ..To analyse the fertility rates, complications and recurrences in a group of women who have undergone radical vaginal trachelectomy and pelvic lymphadenectomy for early-stage cervical cancer...
  36. ncbi Reduced lymph node yield in rectal carcinoma specimen after neoadjuvant radiochemotherapy has no prognostic relevance
    Dietrich Doll
    Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675, Munich, Germany
    World J Surg 33:340-7. 2009
    ..Neoadjuvant radiochemotherapy for rectal carcinoma reduces the number of lymph nodes in the resection specimen; the prognostic impact of this reduced lymph node yield has not been determined...
  37. pmc Survival results of a multicentre phase II study to evaluate D2 gastrectomy for gastric cancer
    M Degiuli
    Department of Oncology, Division of Surgery, Via Cavour 31, 10123 Turin, Italy
    Br J Cancer 90:1727-32. 2004
    ..Our results suggest a survival benefit for pancreas-preserving D2 dissection in Italian patients with gastric cancer if performed in experienced centres. A phase III trial among exclusively experienced centres is urgently needed...
  38. pmc Randomised study of systematic lymphadenectomy in patients with epithelial ovarian cancer macroscopically confined to the pelvis
    A Maggioni
    Istituto Europeo di Oncologia, Milan, Italy
    Br J Cancer 95:699-704. 2006
    ..0-9.2%) respectively for CONTROL and SL. SL detects a higher proportion of patients with metastatic lymph nodes. This trial may have lacked power to exclude clinically important effects of SL on progression free and overall survival...
  39. ncbi Outcome of patients with known metastatic gastric cancer undergoing resection with therapeutic intent
    Jason S Gold
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 14:365-72. 2007
    ..Metastatic gastric cancer has a dismal prognosis. We identified a subset of patients where surgical resection with therapeutic intent was undertaken in the setting of known metastatic disease...
  40. ncbi Morbidity, survival, and site of recurrence after mediastinal lymph-node dissection versus systematic sampling after complete resection for non-small cell lung cancer
    Didier Lardinois
    Division of Thoracic Surgery, University Hospital, Zurich, Switzerland
    Ann Thorac Surg 80:268-74; discussion 274-5. 2005
    ....
  41. ncbi Prognosis of the upper limb following surgery and radiation for breast cancer
    Teresa S Lee
    Discipline of Physiotherapy, University of Sydney, PO Box 170, Lidcombe, NSW, 2141, Australia
    Breast Cancer Res Treat 110:19-37. 2008
    ..Radiation that excludes the axilla does not appear to be a strong prognostic indicator of adverse upper limb outcomes...
  42. ncbi Laparoscopy-assisted distal gastrectomy with D2 lymph node dissection for gastric cancer: technical and oncologic aspects
    K Y Song
    Department of Surgery, The Catholic University of Korea, College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul, Korea
    Surg Endosc 22:655-9. 2008
    ....
  43. ncbi Effect of the number of uninvolved nodes on survival in early breast cancer
    Vincent Vinh-Hung
    Department of Radiotherapy, Oncologisch Centrum, AZ VUB, B 1090 Jette, Belgium
    Oncol Rep 10:363-8. 2003
    ..The incidental finding that ratio-based characterization of node involvement might be a prognostic factor will be further investigated...
  44. ncbi A surgical and pathological based classification of resective treatment of pancreatic cancer. Summary of an international workshop on surgical procedures in pancreatic cancer
    S Pedrazzoli
    Dipartimento di Scienze Mediche e Chirurgiche, Semeiotica Chirurgica, University of Padova, Italy
    Dig Surg 16:337-45. 1999
    ..The extent of pancreatic resection and lymphadenectomy, both for Kausch-Whipple pancreatoduodenectomy and for left pancreatectomy, is variable between surgeons, according to their training...
  45. ncbi Self-reported arm-lymphedema and functional impairment after breast cancer treatment--a nationwide study of prevalence and associated factors
    Rune Gärtner
    Department of Breast Surgery, Rigshospitalet 3103, Copenhagen University, 2100 Copenhagen, Denmark
    Breast 19:506-15. 2010
    ..Giving up activities was associated with pain and swelling/heaviness, younger age, ALND, chemotherapy, time elapsed since surgery, and surgery on the dominant side. Radiotherapy and type of breast surgery were of no importance...
  46. pmc Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality
    Charles J Yeo
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Surg 236:355-66; discussion 366-8. 2002
    ..To evaluate, in a prospective, randomized single-institution trial, the end points of operative morbidity, operative mortality, and survival in patients undergoing standard versus radical (extended) pancreaticoduodenectomy...
  47. ncbi A micromorphometry-based concept for routine classification of sentinel lymph node metastases and its clinical relevance for patients with melanoma
    H Starz
    Department of Dermatology and Allergology, Klinikum Augsburg, Augsburg, Germany
    Cancer 91:2110-21. 2001
    ..Correspondingly high standards in terms of specificity, sensitivity, and microstaging are required for the evaluation of SLNs...
  48. ncbi Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO)
    Marcos Ballester
    Department of Obstetrics and Gynaecology, Tenon University Hospital, Paris, France
    Lancet Oncol 12:469-76. 2011
    ..We did a prospective, multicentre cohort study to assess the detection rate and diagnostic accuracy of the SLN procedure in predicting the pathological pelvic-node status in patients with early stage endometrial cancer...
  49. ncbi Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection
    Claude Nos
    Department of Gynecologic and Oncologic Surgery, Hopital Europeen Georges Pompidou, Paris, France
    Ann Surg Oncol 14:2490-6. 2007
    ....
  50. ncbi ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer
    Didier Lardinois
    Department of Thoracic Surgery, University Hospital, Zurich, Switzerland
    Eur J Cardiothorac Surg 30:787-92. 2006
    ..The adherence to these guidelines will standardize the intraoperative lymph node staging and pathologic evaluation, and improve pathologic staging, which will help decide on the best adjuvant therapy...
  51. ncbi Risk factors for arm lymphedema following breast cancer diagnosis in Black women and White women
    Kathleen A Meeske
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Breast Cancer Res Treat 113:383-91. 2009
    ....
  52. ncbi Individualization of lymph node dissection in RET (rearranged during transfection) carriers at risk for medullary thyroid cancer: value of pretherapeutic calcitonin levels
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Germany
    Ann Surg 250:305-10. 2009
    ..This study sought to define the need for lymph node dissection in Rearranged during Transfection (RET) carriers at risk for hereditary medullary thyroid cancer...
  53. pmc Treatment of node-positive endometrial cancer with complete node dissection, chemotherapy and radiation therapy
    T Onda
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
    Br J Cancer 75:1836-41. 1997
    ..In summary, aortic and pelvic lymphadenectomy and subsequent chemotherapy and radiation therapy based on node status seem to improve the survival of endometrial cancer patients with positive nodes...
  54. pmc New metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinoma
    Ugwuji N Maduekwe
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 17:1267-77. 2010
    ..The ratio of metastatic to examined nodes (N ratio) is an effective prognostic tool, but has not been examined in Western patients undergoing primarily D1 lymphadenectomy...
  55. ncbi Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis
    J A Petrek
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer 92:1368-77. 2001
    ..The current study provides further support for treatments that limit lymph node dissection. The authors are prospectively evaluating patients undergoing sentinel lymph node biopsy...
  56. ncbi Number of nodes examined and staging accuracy in colorectal carcinoma
    J H Wong
    Department of Surgery, University of Hawaii School of Medicine, and Research Administration and Department of Pathology, Queen s Medical Center, Honolulu, HI 96813, USA
    J Clin Oncol 17:2896-900. 1999
    ..The objective of this study was to determine the number of nodes that need to be examined to accurately reflect the histology of the regional lymphatics in colorectal carcinoma...
  57. ncbi Survival effect of para-aortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective cohort analysis
    Yukiharu Todo
    Division of Gynaecologic Oncology, National Hospital Organization, Hokkaido Cancer Centre, Sapporo, Japan
    Lancet 375:1165-72. 2010
    ....
  58. ncbi Axillary reverse mapping (ARM): a new concept to identify and enhance lymphatic preservation
    Margaret Thompson
    Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Ann Surg Oncol 14:1890-5. 2007
    ..Mapping the drainage of the arm with blue dye (axillary reverse mapping, ARM) decreases the likelihood of disruption of lymphatics and subsequent lymphedema...
  59. pmc Role of axillary clearance after a tumor-positive sentinel node in the administration of adjuvant therapy in early breast cancer
    Marieke E Straver
    The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands
    J Clin Oncol 28:731-7. 2010
    ..CONCLUSION Absence of knowledge regarding the extent of nodal involvement in the ART arm appears to have no major impact on the administration of adjuvant therapy...
  60. ncbi Pattern and clinical predictors of lymph node metastases in epithelial ovarian cancer
    P Harter
    Department of Gynecology, Dr Horst Schmidt Klinik HSK, Wiesbaden, Germany
    Int J Gynecol Cancer 17:1238-44. 2007
    ..Systematic pelvic and para-aortic lymphadenectomy remains part of staging in EOC. Patients with EOC should be offered the opportunity to receive state-of-the-art treatment including surgery...
  61. ncbi Lymphedema following axillary lymph node dissection for breast cancer
    George H Sakorafas
    4th Department of Surgery, Attikon University Hospital, Athens University, Medical School, Arkadias 19 21, GR 115 26 Athens, Greece
    Surg Oncol 15:153-65. 2006
    ..Prevention is of key importance to avoid lymphedema formation. The application of the sentinel lymph node biopsy in the management of breast cancer has been associated with a reduced incidence of lymphedema formation...
  62. ncbi Clinical impact of lymphadenectomy extent in resectable gastric cancer of advanced stage
    Roderich E Schwarz
    Division of Surgical Oncology RES, The Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA
    Ann Surg Oncol 14:317-28. 2007
    ..The value of an extended lymph node dissection (ELND) remains unclear in this setting...
  63. ncbi Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial
    Pierluigi Benedetti Panici
    Department of Obstetrics and Gynecology, La Sapienza University of Rome, Rome, Italy
    J Natl Cancer Inst 100:1707-16. 2008
    ..We conducted a randomized clinical trial to determine whether the addition of pelvic systematic lymphadenectomy to standard hysterectomy with bilateral salpingo-oophorectomy improves overall and disease-free survival...
  64. ncbi Hospital lymph node examination rates and survival after resection for colon cancer
    Sandra L Wong
    MS, 1500 E Medical Center Dr, 3310 CCC, Ann Arbor, MI 48109
    JAMA 298:2149-54. 2007
    ..The National Quality Forum and other organizations recently endorsed a 12-node minimum as a measure of hospital quality...
  65. ncbi Lymphedema and quality of life in survivors of early-stage breast cancer
    Sarah M Beaulac
    Department of Epidemiology, Boston University Medical Center, Mass, USA
    Arch Surg 137:1253-7. 2002
    ..Despite increased use of breast-conserving surgery, lymphedema rates are similar to those with more radical surgery...
  66. ncbi Central cervical nodal metastasis from papillary thyroid microcarcinoma: pattern and factors predictive of nodal metastasis
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Pungnap dong, Songpa Gu, Seoul, 138 736, South Korea
    Ann Surg Oncol 15:2482-6. 2008
    ..We evaluated the pattern and factors predictive of central cervical metastasis from PTMC...
  67. ncbi Ratio between positive lymph nodes and total dissected axillaries lymph nodes as an independent prognostic factor for disease-free survival in patients with breast cancer
    Luciano José Megale Costa
    Department of Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Am J Clin Oncol 27:304-6. 2004
    ..213; p < 0.001). It is concluded that P/D ratio could become a simple, inexpensive, and easily available prognostic factor for patients undergoing conventional chemotherapy for BC...
  68. ncbi Lymph node recoveries from 2427 pT3 colorectal resection specimens spanning 45 years: recommendations for a minimum number of recovered lymph nodes based on predictive probabilities
    Neal S Goldstein
    Department of Anatomic Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, U S A
    Am J Surg Pathol 26:179-89. 2002
    ..Thus, all palpable lymph nodes should be recovered, including those that are 1 or 2 mm...
  69. pmc Risk factors for short- and long-term complications after groin surgery in vulvar cancer
    F Hinten
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    Br J Cancer 105:1279-87. 2011
    ....
  70. ncbi Sentinel lymph node biopsy compared with axillary lymph node dissection in early breast cancer: a meta-analysis
    Zhen Wang
    Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China
    Breast Cancer Res Treat 129:675-89. 2011
    ..In conclusion, SLNB can be recommended as preferred care for SLN-negative patients and selected patients with SLN-micrometastasis. Despite this, ALND remains the standard management in breast cancer patients with SLN-macrometastasis...
  71. ncbi First 100 early endometrial cancer cases treated with laparoendoscopic single-site surgery: a multicentric retrospective study
    Anna Fagotti
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy
    Am J Obstet Gynecol 206:353.e1-6. 2012
    ..We sought to assess feasibility and perioperative outcomes for laparoendoscopic single-site surgery (LESS) in early endometrial cancer...
  72. ncbi Prognostic significance of the metastatic lymph node ratio in patients with gastric cancer
    Sung Ryol Lee
    Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung dong, Jongno Ku, Seoul, 110 746, South Korea
    World J Surg 36:1096-101. 2012
    ....
  73. pmc Lymphadenectomy and histologic subtype affect overall survival of soft tissue sarcoma patients with nodal metastases
    Chigusa Sawamura
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Clin Orthop Relat Res 471:926-31. 2013
    ..The survival is believed to be poor if lymph node metastases occur and the potential benefit of lymphadenectomy is unclear...
  74. ncbi Phase 3 trial of postoperative chemotherapy alone versus chemoradiation therapy in stage III-IV gastric cancer treated with R0 gastrectomy and D2 lymph node dissection
    Tae Hyun Kim
    Research Institute and Hospital, National Cancer Center, Goyang, Korea
    Int J Radiat Oncol Biol Phys 84:e585-92. 2012
    ..To compare chemotherapy alone with chemoradiation therapy in stage III-IV(M0) gastric cancer treated with R0 gastrectomy and D2 lymph node dissection...
  75. ncbi Prophylactic central neck dissection and local recurrence in papillary thyroid cancer: a meta-analysis
    Tarek Zetoune
    Department of Surgery, Weill Cornell Medical College, New York, NY, USA
    Ann Surg Oncol 17:3287-93. 2010
    ..We performed a meta-analysis to assess the effect of pCND on local recurrence in PTC...
  76. ncbi Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial
    Robert E Mansel
    Department of Surgery, Cardiff University, Cardiff, UK
    J Natl Cancer Inst 98:599-609. 2006
    ....
  77. ncbi The risk of developing arm lymphedema among breast cancer survivors: a meta-analysis of treatment factors
    REBECCA J TSAI
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA
    Ann Surg Oncol 16:1959-72. 2009
    ..Numerous studies have attempted to identify treatment and prognostic factors for arm lymphedema, yet the magnitude of these associations remains inconsistent...
  78. ncbi Lymph node involvement in epithelial ovarian cancer: analysis of 276 pelvic and paraaortic lymphadenectomies and surgical implications
    Philippe Morice
    Department of Surgery, Institut Gustave Roussy, Villejuif, France
    J Am Coll Surg 197:198-205. 2003
    ..The purpose was to determine the factors influencing nodal involvement and topography of pelvic and paraaortic node involvement in ovarian carcinoma...
  79. pmc Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma
    Harue Tada
    Department of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Sakyo ku, Kyoto, Japan
    BMC Cancer 9:47. 2009
    ..We aimed to identify the factors that are associated with the occurrence of lymphedema after lymph node dissection for the treatment of ovarian or uterine carcinoma...
  80. ncbi A comparison of quality of life between vulvar cancer patients after sentinel lymph node procedure only and inguinofemoral lymphadenectomy
    M H M Oonk
    Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands
    Gynecol Oncol 113:301-5. 2009
    ..Moreover, it was evaluated what patients would advise relatives on the application of the SLN-procedure in light of possible false negative results...
  81. pmc Number of lymph nodes examined and prognosis among pathologically lymph node-negative patients after preoperative chemoradiation therapy for rectal adenocarcinoma
    Chiaojung Jillian Tsai
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 117:3713-22. 2011
    ....
  82. ncbi Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non-small cell carcinoma: results of the American College of Surgery Oncology Group Z0030 Trial
    Gail E Darling
    University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 141:662-70. 2011
    ..To determine whether mediastinal lymph node dissection improves survival compared with mediastinal lymph node sampling in patients undergoing resection for N0 or nonhilar N1, T1, or T2 non-small cell lung cancer...
  83. ncbi Axillary reverse mapping for breast cancer
    Masakuni Noguchi
    Department of Breast and Endocrine Surgery, Kanazawa Medical University Hospital, Uchinada daigaku 1 1, Ishikawa 920 0293, Japan
    Breast Cancer Res Treat 119:529-35. 2010
    ..The success of ARM in reducing lymphedema has not yet been determined. Further studies are needed before this can be accepted as a standard procedure in surgical management of breast cancer...
  84. ncbi Complications of lymphadenectomy for gynecologic cancer
    A Achouri
    Service de Chirurgie Cancérologique Gynécologique et du Sein, Hopital Europeen Georges Pompidou, AP HP, Paris, France
    Eur J Surg Oncol 39:81-6. 2013
    ..Here, our objective was to evaluate the incidence and risk factors of SPOLs and LLL after pelvic and/or aortocaval lymphadenectomy for gynecologic malignancies...
  85. ncbi Lymphatic drainage pathways of the breast and the upper limb
    Tom Bennett Britton
    Department of Academic Oncology, King s College London, UK
    Nucl Med Commun 30:427-30. 2009
    ..To determine how often the sentinel lymph node (SLN) draining the breast is the same node as the SLN draining the upper limb. A common SLN might increase the risk of upper limb breast cancer-related lymphoedema after SLN biopsy...
  86. ncbi Prognostic significance of lymph node metastases in pancreatic head cancer treated with extended lymphadenectomy: not just a matter of numbers
    Paolo Massucco
    Unit of Hepato biliary pancreatic and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy
    Ann Surg Oncol 16:3323-32. 2009
    ....
  87. ncbi Different patterns of recurrence in gastric cancer depending on Lauren's histological type: longitudinal study
    Daniele Marrelli
    Chirurgia Oncologica, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    World J Surg 26:1160-5. 2002
    ..The notable difference in the risk of peritoneal recurrence between the intestinal and diffuse types should be taken into consideration in the therapeutic approach to gastric cancer...
  88. pmc Positive nonsentinel node status predicts mortality in patients with cutaneous melanoma
    Charlotte Ariyan
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg Oncol 16:186-90. 2009
    ..5). We conclude that positive NSLN is an independent predictor of disease-specific survival in patients with cutaneous melanoma...
  89. ncbi Recurrence pattern of squamous cell carcinoma of the thoracic esophagus after extended radical esophagectomy with three-field lymphadenectomy
    Satoru Nakagawa
    The Division of Digestive and General Surgery, Niigata Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8122, Japan
    J Am Coll Surg 198:205-11. 2004
    ..But even if this operation is performed, some patients still experience relapse of the disease. The purpose of this study was to clarify the pattern and timing of recurrence after extended radical esophagectomy...
  90. ncbi Complete axillary lymph node dissection versus clinical follow-up in breast cancer patients with sentinel node micrometastasis: final results from the multicenter clinical trial AATRM 048/13/2000
    Montserrat Solà
    Hospital Universitari Germans Trias i Pujol de Badalona, Barcelona, Spain
    Ann Surg Oncol 20:120-7. 2013
    ....
  91. ncbi Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients
    M R Pelizzo
    Department of Medical and Surgical Sciences, Institute of Surgical Pathology, University of Padova, Padova, Italy
    Eur J Surg Oncol 33:493-7. 2007
    ....
  92. ncbi Prognostic factors for recurrence and survival in primary vulvar squamous cell cancer
    Ali Ayhan
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Baskent University Faculty of Medicine, Ankara, Sihhiye, Turkey
    Acta Obstet Gynecol Scand 87:1143-9. 2008
    ..To evaluate survival estimates and clinico-pathological variables in women with primary vulvar squamous cancer...
  93. ncbi Impact of prophylactic central neck lymph node dissection on early recurrence in papillary thyroid carcinoma
    Tracy Ann Moo
    Department of Surgery, New York Presbyterian Hospital Cornell, 525 East 68th Street, New York, NY 10065, USA
    World J Surg 34:1187-91. 2010
    ..The present study compares local recurrence rates in PTC patients undergoing total thyroidectomy with and without prophylactic CNLD...
  94. ncbi Long-term oncological outcome after post-chemotherapy retroperitoneal lymph node dissection in men with metastatic nonseminomatous germ cell tumour
    Aude Flechon
    Department of Medical Oncology, Centre Leon Berard, Lyon, France
    BJU Int 106:779-85. 2010
    ....
  95. ncbi The pattern and prevalence of lymphatic spread in thoracic oesophageal squamous cell carcinoma
    Junqiang Chen
    Department of Radiation Oncology, The Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, PR China
    Eur J Cardiothorac Surg 36:480-6. 2009
    ..Oesophageal squamous cell carcinoma (SCC) is a common type of cancer in China. The knowledge of its pattern of lymphatic metastasis would be of clinical value for surgical and radiation oncologists to treat this disease...
  96. ncbi Lymph node assessment in cervical cancer: prognostic and therapeutic implications
    L T Gien
    Division of Gynecologic Oncology, Odette Cancer Centre, Toronto, Ontario, Canada
    J Surg Oncol 99:242-7. 2009
    ..Finally, the prognostic and therapeutic implications of lymphadenectomy in cervical cancer will be reviewed...
  97. ncbi Axillary reverse mapping with indocyanine fluorescence imaging in patients with breast cancer
    Masakuni Noguchi
    Department of Breast and Endocrine Surgery, Kanazawa Medical University Hospital, Uchinada daigaku, Japan
    J Surg Oncol 101:217-21. 2010
    ..The ARM technique was proposed to prevent arm lymphedema after ALND and/or SLN biopsy. However, several problems remain to be resolved in the practical application of this technique...
  98. ncbi Comparison of long-term outcomes of laparoscopy-assisted and open distal gastrectomy for early gastric cancer
    Joo Ho Lee
    Department of Surgery, Ewha Medical Center, Ewha Womans University School of Medicine, 911 1 Mok Dong, Yangcheon Ku, Seoul, 158 710, Republic of Korea
    Surg Endosc 23:1759-63. 2009
    ..We evaluated the long-term outcome of LADG compared with conventional open distal gastrectomy (ODG) for EGC...
  99. pmc A contemporary, population-based study of lymphedema risk factors in older women with breast cancer
    Tina W F Yen
    Division of General Surgery, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Ann Surg Oncol 16:979-88. 2009
    ..We studied potential risk factors for lymphedema in a contemporary population of older breast cancer patients...
  100. ncbi Recent advances in breast cancer-related lymphedema of the arm: lymphatic pump failure and predisposing factors
    Anthony W B Stanton
    Division of Cardiac and Vascular Sciences, Dermatology, St George s Hospital Medical School, University of London, London, United Kingdom
    Lymphat Res Biol 7:29-45. 2009
    ..Future research must focus on prospective observations made from before surgery until BCRL develops...
  101. ncbi Sentinel lymph node biopsy in breast cancer guided by indocyanine green fluorescence
    D Murawa
    Department of Surgery and Surgical Oncology, Robert Rössle Hospital, HELIOS Hospital, Berlin, Germany
    Br J Surg 96:1289-94. 2009
    ..This study evaluated the feasibility of fluorescence detection of SLNs with indocyanine green (ICG) for lymphatic mapping and SLN biopsy...

Research Grants32

  1. Biology of Headpin (a novel serpin) in Oral Cancer
    Gary Clayman; Fiscal Year: 2006
    ..Progress in this area could lead to development of new molecular based targets for the management of oral cancer. ..
  2. Neoadjuvant Cytokine Immunotherapy by PLA Microspheres
    Michael Sabel; Fiscal Year: 2007
    ..I will pursue this area of investigation as a full-time faculty member, with full commitment from the Department of General Surgery and the Division of Surgical Oncology at the University of Michigan Medical Center. ..
  3. Radioactive Iodide Therapy of Pediatric Graves' Disease
    Scott A Rivkees; Fiscal Year: 2010
    ....
  4. Effective surveillance strategies for melanoma patients
    Janice N Cormier; Fiscal Year: 2010
    ..Collectively, the outcomes from this proposal will provide evidence-based guidelines for surveillance, which in turn will promote the cost-effective use of health care resources. ..
  5. Primary Hormonal Therapy for DCIS of the Breast
    EUN SIL HWANG; Fiscal Year: 2008
    ..If patients could safely be spared from cancer progression while avoiding the morbidity of surgery and radiation for DCIS, the full benefit of early breast cancer detection could be realized. ..
  6. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  7. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  8. BREAST CANCER PATTERNS OF CARE AND MORBIDITY
    Sandra Norman; Fiscal Year: 2007
    ..Preliminary data from the parent study suggest that only longer follow-up can capture the interplay of time-dependent risks, ongoing treatment, and patient characterisitics that occur over a longer period of time. ..
  9. INJURY TO LIVER SINUSOIDAL ENDOTHELIAL CELLS
    Steven Strasberg; Fiscal Year: 2003
    ..A potentially beneficial improvements in preservation solutions are identified they will be tested in whole isolated livers and by transplantation in the rat. ..
  10. In Vivo Selection of Ligands for Targeted Therapy
    David Krag; Fiscal Year: 2003
    ..Successful completion of this clinical study will result in demonstration of a satisfactory safety profile and short peptides that bind selectively to tumor tissue. ..
  11. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate that these studies will yield new insights into the mechanisms of hypoglycemic brain injury and may lead to the development of practical strategies for reducing hypoglycemic brain injury. ..
  12. Targeted Enzymes for Prodrug Therapy
    David Krag; Fiscal Year: 2007
    ..Successful completion of these experiments will result in demonstration of novel targeted effector molecules that bind selectively to tumors and activate cytotoxic prodrugs. ..
  13. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..These studies may also lead to the development of new care practices in Neonatal Intensive Care Units and extend the field of developmental chronobiology to the bedside. ..
  14. Bevacizumab and radiation therapy for sarcomas
    Sam Yoon; Fiscal Year: 2007
    ..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. [unreadable] [unreadable] [unreadable]..
  15. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
  16. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  17. TARGETING BREAST CANCER WITH SMALL LIGANDS
    David Krag; Fiscal Year: 2006
    ..3) Use the structure-based, homologous analog and biased library approach to make educated designs to increase the affinity of the Grb7 ligands ..
  18. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  19. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
  20. Oncology Clinical Trial Accrual Study
    ANNEKE SCHROEN; Fiscal Year: 2009
    ....
  21. Evaluating the Effectiveness of Lung Cancer Treatment in the Elderly
    Juan Wisnivesky; Fiscal Year: 2009
    ..The findings from this project will provide information that can directly impact the care of elderly patients with NSCLC and inform the design of future trials of lung cancer treatment strategies. ..
  22. Prognosis and Effectiveness of Advanced Lung Cancer Treatment in the Elderly
    Juan P Wisnivesky; Fiscal Year: 2010
    ..This study will provide information regarding the efficacy of several therapies and may help resolve several controversies regarding the staging and treatment of elderly patients with advanced stage lung cancer. ..
  23. POLYVALENT VACCINE--PHASE III TRIAL IN STAGE IV MELANOMA
    Donald Morton; Fiscal Year: 2002
    ..Determine whether there is any correlation between such responses and the clinical course of vaccine patients in a prospective multicenter trial. ..
  24. CHILDRENS CANCER GROUP
    Katherine Matthay; Fiscal Year: 2002
    ..Our strong biology research laboratories in brain tumors, neuroblastoma and myeloproliferative disorders are conducting multiple biology studies in the Group and providing new information for future studies. ..
  25. The Prevalence of Barrett's Esophagus in Patients with *
    Blair Jobe; Fiscal Year: 2004
    ..In addition, this study will enhance our understanding of the natural history of esophageal injury in patients with extraesophageal reflux and raise awareness of non-GERD risk factors. ..
  26. PATTERNS CARE FOR CANCER PATIENTS AT END OF LIFE
    Ellen McCarthy; Fiscal Year: 2002
    ..Information obtained from the study can be used to improve the quality of care for patients at the end of life and help to determine the nature and amount of resources that might be required to meet patients' needs. ..
  27. 131 I-MIBG Escalating Dose Rapid Sequence Double Infusi*
    Katherine Matthay; Fiscal Year: 2004
    ..Significance: The higher tumor-specific radiation doses possible with this protocol may provide a treatment to improve response and survival in children with resistant neuroblastoma. ..
  28. SLC2A9, A Candidate ER GLUT in Normal and Cancer Cells
    Jeffrey Moley; Fiscal Year: 2002
    ..Identification of SLC2A9 as the endoplasmic reticulum glucose transporter will improve understanding of GSDs, and of glucose metabolism in benign and malignant tissues. ..
  29. Physical Activity and Lymphedema Project (PAL Trial)
    Kathryn Schmitz; Fiscal Year: 2007
    ..The knowledge gained from this study may impact recommendations for therapeutic regimens, participation in activities of daily living, and recommendations for exercise for health promotion in BrCa survivors. ..
  30. MENTORING & ADVANCED RESEARCH TRAINING FOR WRHR SCHOLARS
    Jonathan Berek; Fiscal Year: 2008
    ..This cadre of Scholars will be among future leaders in women's reproductive health research in the United States. [unreadable] [unreadable] [unreadable]..
  31. DEVELOPING QUALITY INDICATORS FOR ADVANCED CANCER CARE
    Craig Earle; Fiscal Year: 2007
    ..Once identified, reasons could be sought and appropriate interventions, such as increasing access to palliative services, could be instituted. ..
  32. Cost-Effectiveness--Treatments--Ductal Carcinoma In Situ
    Jennifer Griggs; Fiscal Year: 2004
    ..abstract_text> ..