laser coagulation

Summary

Summary: The coagulation of tissues using lasers. These lasers produce light in the visible green wavelength that is selectively absorbed by hemoglobin, and thus it is possible to seal bleeding blood vessels.

Top Publications

  1. ncbi Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 117:2146-51. 2010
  2. pmc Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    Michael J Elman
    Elman Retina Group, PA, Baltimore, Maryland, USA
    Ophthalmology 118:609-14. 2011
  3. ncbi Primary End Point (Six Months) Results of the Ranibizumab for Edema of the mAcula in diabetes (READ-2) study
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Ophthalmology 116:2175-81.e1. 2009
  4. ncbi Prospective randomised controlled trial comparing sub-threshold micropulse diode laser photocoagulation and conventional green laser for clinically significant diabetic macular oedema
    J Figueira
    University Hospital and Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, Portugal
    Br J Ophthalmol 93:1341-4. 2009
  5. ncbi Macular grid photocoagulation after intravitreal triamcinolone acetonide for diffuse diabetic macular edema
    Se Woong Kang
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Arch Ophthalmol 124:653-8. 2006
  6. ncbi Microperimetry and fundus autofluorescence in diabetic macular edema: subthreshold micropulse diode laser versus modified early treatment diabetic retinopathy study laser photocoagulation
    Stela Vujosevic
    Fondazione GB Bietti, IRCCS, Rome, Italy
    Retina 30:908-16. 2010
  7. pmc Comparison of the modified Early Treatment Diabetic Retinopathy Study and mild macular grid laser photocoagulation strategies for diabetic macular edema
    Donald S Fong
    Arch Ophthalmol 125:469-80. 2007
  8. ncbi Aggressive posterior retinopathy of prematurity
    Kimberly A Drenser
    Associated Retinal Consultants, Royal Oak, Michigan, USA
    Retina 30:S37-40. 2010
  9. pmc Exploratory analysis of diabetic retinopathy progression through 3 years in a randomized clinical trial that compares intravitreal triamcinolone acetonide with focal/grid photocoagulation
    Neil M Bressler
    Jaeb Center for Health Research, 15310 Amberly Dr, STE 350, Tampa, FL 33647, USA
    Arch Ophthalmol 127:1566-71. 2009
  10. ncbi Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction
    Aparna Ramasubramanian
    Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Br J Ophthalmol 96:356-9. 2012

Research Grants

  1. Nonpeptide Somatostatin Agonists for Retinopathy
    Maria Grant; Fiscal Year: 2005
  2. Nonpeptide Somatostatin Agonists for Retinopathy
    Gideon Shapiro; Fiscal Year: 2003
  3. The Predictive Value of Pre-plus Disease in ROP
    David Wallace; Fiscal Year: 2008
  4. Breast Tissue ablation by Conductive Heating
    Gal Shafirstein; Fiscal Year: 2007
  5. Endothelial Progenitor Cell Biology in Type 1 Diabetes
    Timothy Crombleholme; Fiscal Year: 2008
  6. Endothelial Progenitor Cell Recruitment in Diabetic Mice
    Timothy Crombleholme; Fiscal Year: 2008
  7. Endothelial Transmigration Across the RPE Barrier
    Mary Elizabeth Hartnett; Fiscal Year: 2005
  8. Twin-Twin Transfusion Syndrome Trial
    Timothy Crombleholme; Fiscal Year: 2004
  9. DERMAL-EPIDERMAL INTERACTIONS IN DIABETIC WOUND HEALING
    Timothy Crombleholme; Fiscal Year: 2004
  10. Chitosan hemostatic device for laparoscopic applications
    Hua Xie; Fiscal Year: 2005

Detail Information

Publications264 found, 100 shown here

  1. ncbi Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 117:2146-51. 2010
    ..To determine the long-term effects of ranibizumab (RBZ) in patients with diabetic macular edema (DME)...
  2. pmc Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    Michael J Elman
    Elman Retina Group, PA, Baltimore, Maryland, USA
    Ophthalmology 118:609-14. 2011
    ..5 mg ranibizumab or 4 mg triamcinolone combined with focal/grid laser compared with focal/grid laser alone for treatment of diabetic macular edema (DME)...
  3. ncbi Primary End Point (Six Months) Results of the Ranibizumab for Edema of the mAcula in diabetes (READ-2) study
    Quan Dong Nguyen
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Ophthalmology 116:2175-81.e1. 2009
    ..To compare ranibizumab with focal/grid laser or a combination of both in diabetic macular edema (DME)...
  4. ncbi Prospective randomised controlled trial comparing sub-threshold micropulse diode laser photocoagulation and conventional green laser for clinically significant diabetic macular oedema
    J Figueira
    University Hospital and Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, Portugal
    Br J Ophthalmol 93:1341-4. 2009
    ....
  5. ncbi Macular grid photocoagulation after intravitreal triamcinolone acetonide for diffuse diabetic macular edema
    Se Woong Kang
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Arch Ophthalmol 124:653-8. 2006
    ..To evaluate the clinical outcomes of macular laser photocoagulation after the intravitreal injection of 4 mg of triamcinolone acetonide (IVTA) for diffuse diabetic macular edema (DME)...
  6. ncbi Microperimetry and fundus autofluorescence in diabetic macular edema: subthreshold micropulse diode laser versus modified early treatment diabetic retinopathy study laser photocoagulation
    Stela Vujosevic
    Fondazione GB Bietti, IRCCS, Rome, Italy
    Retina 30:908-16. 2010
    ....
  7. pmc Comparison of the modified Early Treatment Diabetic Retinopathy Study and mild macular grid laser photocoagulation strategies for diabetic macular edema
    Donald S Fong
    Arch Ophthalmol 125:469-80. 2007
    ....
  8. ncbi Aggressive posterior retinopathy of prematurity
    Kimberly A Drenser
    Associated Retinal Consultants, Royal Oak, Michigan, USA
    Retina 30:S37-40. 2010
    ..The purpose of this study was to review the anatomic and functional outcomes of aggressive posterior retinopathy of prematurity occurring at the authors' institution...
  9. pmc Exploratory analysis of diabetic retinopathy progression through 3 years in a randomized clinical trial that compares intravitreal triamcinolone acetonide with focal/grid photocoagulation
    Neil M Bressler
    Jaeb Center for Health Research, 15310 Amberly Dr, STE 350, Tampa, FL 33647, USA
    Arch Ophthalmol 127:1566-71. 2009
    ..To compare the effect of intravitreal triamcinolone acetonide with focal/grid photocoagulation on the progression of diabetic retinopathy...
  10. ncbi Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction
    Aparna Ramasubramanian
    Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Br J Ophthalmol 96:356-9. 2012
    ..To evaluate the effect of supplemental intravitreal bevacizumab for management of Coats' disease...
  11. ncbi Comparison of laser photocoagulation for diabetic retinopathy using 532-nm standard laser versus multispot pattern scan laser
    Manish Nagpal
    Retina Foundation, Near Shahibag Underbridge, Shahibag, Ahmedabad, Gujarat, India 380004
    Retina 30:452-8. 2010
    ....
  12. pmc Factors associated with improvement and worsening of visual acuity 2 years after focal/grid photocoagulation for diabetic macular edema
    Lloyd Paul Aiello
    Joslin Diabetes Center and Department of Ophthalmology, Harvard Medical School, Cambridge, Massachusetts, USA
    Ophthalmology 117:946-53. 2010
    ..net) trial comparing triamcinolone with focal/grid laser...
  13. ncbi Lipid-lowering drug atorvastatin as an adjunct in the management of diabetic macular edema
    Amod Gupta
    Department of Ophthalmology, Postgraduate Institute of Education and Research, Chandigarh, India
    Am J Ophthalmol 137:675-82. 2004
    ....
  14. ncbi Two-year results of a randomized trial of intravitreal bevacizumab alone or combined with triamcinolone versus laser in diabetic macular edema
    Masoud Soheilian
    Ophthalmology Department and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Retina 32:314-21. 2012
    ....
  15. ncbi The impact of pulse duration and burn grade on size of retinal photocoagulation lesion: implications for pattern density
    Daniel Palanker
    Department of Ophthalmology, Stanford University, Stanford, California 94305 4085, USA
    Retina 31:1664-9. 2011
    ..Smaller lesions result in fewer complications but may potentially reduce clinical efficacy. It is worthwhile to reevaluate existing standards for the number and size of lesions needed...
  16. ncbi Combined laser and intravitreal triamcinolone for proliferative diabetic retinopathy and macular edema: one-year results of a randomized clinical trial
    Otacilio O Maia
    Department of Ophthalmology, Hospital Sao Rafael, Monte Tabor Foundation, Salvador, BA, Brazil
    Am J Ophthalmol 147:291-297.e2. 2009
    ..To evaluate laser combined with intravitreal triamcinolone acetonide (IVTA) for the management of patients with proliferative diabetic retinopathy (PDR) and clinically significant macular edema (CSME)...
  17. ncbi Subthreshold micropulse diode laser photocoagulation for diabetic macular edema in Japanese patients
    Kishiko Ohkoshi
    Department of Ophthalmology, St Luke s International Hospital, Tokyo, Japan
    Am J Ophthalmol 149:133-9. 2010
    ..To assess the efficacy and safety of subthreshold micropulse diode laser photocoagulation for diabetic macular edema (ME)...
  18. ncbi Induction of nestin, Ki-67, and cyclin D1 expression in Müller cells after laser injury in adult rat retina
    Hideo Kohno
    Department of Ophthalmology, Jikei University School of Medicine, Minatoku, Tokyo 105 8461, Japan
    Graefes Arch Clin Exp Ophthalmol 244:90-5. 2006
    ..The purpose was to examine the expression of nestin, Ki-67, and cyclin D1 in Müller cells after laser injury in adult rat retina...
  19. ncbi Functional and morphological changes of macula after subthreshold micropulse diode laser photocoagulation for diabetic macular oedema
    Y Nakamura
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Eye (Lond) 24:784-8. 2010
    ..To examine the early changes of retinal sensitivity by fundus-related microperimetry after subthreshold micropulse diode laser photocoagulation (SMDLP) for diabetic macular oedema (DMO)...
  20. ncbi Triple therapy of vitrectomy, intravitreal triamcinolone, and macular laser photocoagulation for intractable diabetic macular edema
    Se Woong Kang
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Am J Ophthalmol 144:878-885. 2007
    ..To evaluate the effect of a sequentially combined triple therapy on intractable diabetic macular edema (DME)...
  21. ncbi In vivo retinal morphology after grid laser treatment in diabetic macular edema
    Matthias Bolz
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Ophthalmology 117:538-44. 2010
    ..To analyze immediate in vivo intraretinal morphologic changes secondary to standardized grid photocoagulation using spectral domain optical coherence tomography (SD OCT)...
  22. ncbi Bevacizumab-augmented retinal laser photocoagulation in proliferative diabetic retinopathy: a randomized double-masked clinical trial
    A Mirshahi
    Eye Research Center, Farabi Eye Hospital, Medical Sciences University of Tehran, Tehran, Iran
    Eur J Ophthalmol 18:263-9. 2008
    ..To evaluate the additional therapeutic effect of single intravitreal bevacizumab injection on standard laser treatment in the management of proliferative diabetic retinopathy...
  23. pmc Randomized trial evaluating short-term effects of intravitreal ranibizumab or triamcinolone acetonide on macular edema after focal/grid laser for diabetic macular edema in eyes also receiving panretinal photocoagulation
    Joseph Googe
    Southeastern Retina Associates, P C, Knoxville, Tennessee, USA
    Retina 31:1009-27. 2011
    ..To evaluate 14-week effects of intravitreal ranibizumab or triamcinolone in eyes receiving focal/grid laser for diabetic macular edema and panretinal photocoagulation...
  24. ncbi Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 27:2555-62. 2007
    ..The aim of the current study was to investigate the effect of lutein supplementation on the development of the murine model of laser-induced CNV together with underlying molecular mechanisms...
  25. ncbi Intravitreal triamcinolone plus sequential grid laser versus triamcinolone or laser alone for treating diabetic macular edema: six-month outcomes
    Dennis S C Lam
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
    Ophthalmology 114:2162-7. 2007
    ..To evaluate the efficacy of sequential intravitreal triamcinolone acetonide (TA) injection followed by grid laser photocoagulation for treating diabetic macular edema (DME)...
  26. ncbi Semiautomated patterned scanning laser for retinal photocoagulation
    Mark S Blumenkranz
    Department of Ophthalmology, Stanford University, Stanford, California 94305 5308, USA
    Retina 26:370-6. 2006
  27. ncbi Structural changes of the retina after conventional laser photocoagulation and selective retina treatment (SRT) in spectral domain OCT
    Carsten Framme
    University Eye Hospital, Regensburg, Germany
    Curr Eye Res 34:568-79. 2009
    ..This article aims to investigate the value of SD-OCT in comparing laser lesions produced by conventional laser photocoagulation and selective retina treatment (SRT)...
  28. ncbi Intravitreal dexamethasone implant in patients with persistent diabetic macular edema
    Ilaria Zucchiatti
    Department of Ophthalmology, University Scientific Institute San Raffaele, Via Olgettina 60, Milan, Italy
    Ophthalmologica 228:117-22. 2012
    ..To evaluate the effects of a single injection of Ozurdex over 6 months in eyes with persistent diabetic macular edema (DME)...
  29. ncbi Fundus autofluorescence and Fourier-domain optical coherence tomography imaging of 10 and 20 millisecond Pascal retinal photocoagulation treatment
    M M K Muqit
    Consultant Ophthalmologist and Vitreoretinal Surgeon, Manchester Royal Eye Hospital, Oxford Road, Manchester M13 9WH, UK
    Br J Ophthalmol 93:518-25. 2009
    ....
  30. ncbi Intravitreal bevacizumab plus grid laser photocoagulation or intravitreal bevacizumab or grid laser photocoagulation for diffuse diabetic macular edema: results of the Pan-american Collaborative Retina Study Group at 24 months
    J Fernando Arevalo
    Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Retina 33:403-13. 2013
    ..To evaluate the anatomical and functional outcomes at 24 months in patients with diffuse diabetic macular edema treated with primary intravitreal bevacizumab (IVB) plus grid laser photocoagulation (GLP) or primary IVB alone or GLP alone...
  31. ncbi Vitrectomy for diffuse diabetic macular edema associated with a taut premacular posterior hyaloid
    S D Pendergast
    Retina Associates of Cleveland, Inc, Beachwood, Ohio 44122, USA
    Am J Ophthalmol 130:178-86. 2000
    ..To evaluate the role of vitrectomy in eyes with diffuse diabetic macular edema associated with a taut posterior hyaloid...
  32. ncbi Polypoidal choroidal vasculopathy and treatments
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Curr Opin Ophthalmol 19:208-12. 2008
    ..This review assesses the current knowledge of the clinical characteristics of polypoidal choroidal vasculopathy and treatments...
  33. ncbi Ranibizumab for edema of the macula in diabetes study: 3-year outcomes and the need for prolonged frequent treatment
    Diana V Do
    Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    JAMA Ophthalmol 131:139-45. 2013
    ..To assess the benefit of increased follow-up and treatment with ranibizumab between months 24 and 36 in the Ranibizumab for Edema of the Macula in Diabetes (READ-2) Study...
  34. ncbi Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization
    Xuan Shi
    Department of Vitreoretinal Surgery, Center of Ophthalmology, Germany
    Exp Eye Res 83:1325-34. 2006
    ..These results suggest the involvement of TNF-alpha in the development of laser-induced CNV and its potential use as a therapeutic agent in the age-related macular degeneration...
  35. ncbi Case series of angle-closure glaucoma after laser treatment for retinopathy of prematurity
    Lucas Trigler
    Duke University Eye Center, Durham, NC, USA
    J AAPOS 9:17-21. 2005
    ..Angle-closure glaucoma after laser photocoagulation for ROP is rare. The purpose of this study was to identify additional cases of angle-closure glaucoma following laser treatment for ROP...
  36. ncbi Subthreshold diode micropulse panretinal photocoagulation for proliferative diabetic retinopathy
    J K Luttrull
    Eye (Lond) 22:607-12. 2008
    ..To report the visual acuity and clinical outcomes of a pilot study of subthreshold diode micropulse (SDM) panretinal photocoagulation (PRP) for treatment of diabetic retinopathy...
  37. ncbi Trans-scleral diode laser photocoagulation in proliferative sickle cell retinopathy
    V Seiberth
    Department of Ophthalmology, Klinikum Mannheim, Faculty for Clinical Medicine of the University of Heidelberg, Germany
    Ophthalmology 106:1828-9. 1999
    ..To demonstrate the feasibility of trans-scleral diode laser photocoagulation for the treatment of proliferative sickle cell retinopathy...
  38. pmc Subthreshold diode laser micropulse photocoagulation versus intravitreal injections of bevacizumab in the treatment of central serous chorioretinopathy
    M J Koss
    Unit of Vitreo Retinal Surgery, Department of Ophthalmology, Goethe University, Frankfurt am Main, Germany
    Eye (Lond) 26:307-14. 2012
    ..To evaluate the treatment of central serous chorioretinopathy (CSC) with either subthreshold diode laser MicroPulse (SDM) or intravitreal bevacizumab (BCZ)...
  39. ncbi Quantifying alterations of macular thickness before and after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision
    Masahiko Shimura
    Department of Ophthalmology, Tohoku Graduate School of Medicine, Sendai, Japan
    Ophthalmology 110:2386-94. 2003
    ..To investigate the alterations of macular thickness during and after panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy and good vision, and to compare the outcomes of weekly and biweekly treatments...
  40. ncbi Intravitreal triamcinolone prior to laser treatment of diabetic macular edema: 24-month results of a randomized controlled trial
    Mark C Gillies
    Save Sight Institute, The University of Sydney, Sydney, Australia
    Ophthalmology 118:866-72. 2011
    ..To report the 24 months outcomes from a clinical trial of intravitreal triamcinolone acetonide (IVTA) plus laser versus laser treatment only in eyes with diabetic macular edema (DME)...
  41. ncbi Randomized clinical trial evaluating mETDRS versus normal or high-density micropulse photocoagulation for diabetic macular edema
    Daniel Lavinsky
    Federal University of São Paulo UNIFESP Universidata Federal de São Paulo EPM Escola Paulista de Medicina, Sao Paulo, Brazil
    Invest Ophthalmol Vis Sci 52:4314-23. 2011
    ....
  42. ncbi Panretinal photocoagulation for proliferative diabetic retinopathy: pattern scan laser versus argon laser
    Aimee V Chappelow
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Ophthalmol 153:137-42.e2. 2012
    ..To evaluate the efficacy of the pattern scan laser (PASCAL) in treating newly diagnosed high-risk proliferative diabetic retinopathy (PDR)...
  43. ncbi Long-term therapeutic efficacy of the subthreshold micropulse diode laser photocoagulation for diabetic macular edema
    Yoko Takatsuna
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Jpn J Ophthalmol 55:365-9. 2011
    ..To investigate the long-term efficacy of subthreshold micropulse diode laser photocoagulation (SMDLP) on diabetic macular edema (DME)...
  44. pmc Economic considerations of macular edema therapies
    William E Smiddy
    Bascom Palmer Eye Institute, PO Box 016880, Miami, FL 33101 6880, USA
    Ophthalmology 118:1827-33. 2011
    ..To relate costs and treatment benefits for diabetic macular edema (DME), branch retinal vein occlusion (BRVO), and central retinal vein occlusion (CRVO)...
  45. ncbi Non-damaging retinal phototherapy: dynamic range of heat shock protein expression
    Christopher Sramek
    Hansen Experimental Physics Laboratory, Stanford University, Stanford, California, USA
    Invest Ophthalmol Vis Sci 52:1780-7. 2011
    ..To assess the range of cellular responses to sublethal hyperthermia, expression of the gene encoding a 70 kDa heat shock protein (HSP70) was evaluated after laser irradiation using a transgenic reporter mouse...
  46. ncbi Differences in the temporal expression of regulatory growth factors during choroidal neovascular development
    Wenzheng Hu
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202 5175, USA
    Exp Eye Res 88:79-91. 2009
    ....
  47. ncbi Nonvisible subthreshold micropulse diode laser (810 nm) treatment of central serous chorioretinopathy. A pilot study
    P Lanzetta
    Department of Ophthalmology, University of Udine, Udine Italy
    Eur J Ophthalmol 18:934-40. 2008
    ..To verify the efficacy of nonvisible micropulse diode laser irradiation in the treatment of central serous chorioretinopathy (CSC)...
  48. ncbi Choroidal neovascularization in retinochoroidal coloboma: thermal laser treatment achieves long-term stabilization of visual acuity
    M Spitzer
    Eye (Lond) 20:969-72. 2006
  49. ncbi Intravitreal triamcinolone for diabetic macular edema that persists after laser treatment: three-month efficacy and safety results of a prospective, randomized, double-masked, placebo-controlled clinical trial
    Florian K P Sutter
    Save Sight Institute, Department of Clinical Ophthalmology and Eye Health, The University of Sydney, Sydney, NSW, Australia
    Ophthalmology 111:2044-9. 2004
    ..To determine whether an intravitreal injection of triamcinolone acetonide for persistent diabetic macular edema after adequate laser treatment improves visual acuity...
  50. ncbi Diabetic retinopathy
    Donald S Fong
    Diabetes Care 26:S99-S102. 2003
  51. ncbi Healing of retinal photocoagulation lesions
    Yannis M Paulus
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305 5308, USA
    Invest Ophthalmol Vis Sci 49:5540-5. 2008
    ..To systematically assess the changes in retinal morphology during the healing of retinal photocoagulation lesions of various clinical grades...
  52. ncbi Micropulsed diode laser therapy: evolution and clinical applications
    Sobha Sivaprasad
    Department of Ophthalmology, King s College Hospital, London, UK
    Surv Ophthalmol 55:516-30. 2010
    ..The report includes the rationale and basic principles underlying micropulse diode laser therapy, together with a review of its current clinical applications...
  53. ncbi Experimental mouse ocular hypertension: establishment of the model
    Makoto Aihara
    Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92093, USA
    Invest Ophthalmol Vis Sci 44:4314-20. 2003
    ..To establish an experimental model of ocular hypertension in the mouse...
  54. pmc A mouse model of elevated intraocular pressure: retina and optic nerve findings
    Ronald L Gross
    Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Tex, USA
    Trans Am Ophthalmol Soc 101:163-9; discussion 169-71. 2003
    ..To develop and characterize a mouse model of elevated intraocular pressure (IOP) as a means to investigate the underlying cellular and genetic mechanisms of glaucomatous optic neuropathy...
  55. ncbi Retinopathy of prematurity in the United States
    E M Lad
    Department of Ophthalmology, Stanford University School of Medicine, 1225 Crane Street, Menlo Park, CA 94025, USA
    Br J Ophthalmol 92:320-5. 2008
    ..To determine the incidence of retinopathy of prematurity (ROP) based upon a national database and to identify baseline characteristics, demographic information, comorbidities, and surgical interventions...
  56. pmc Randomized trial of peribulbar triamcinolone acetonide with and without focal photocoagulation for mild diabetic macular edema: a pilot study
    E Chew
    Ophthalmology 114:1190-6. 2007
    ..To provide pilot data on the safety and efficacy of anterior and posterior sub-Tenon injections of triamcinolone either alone or in combination with focal photocoagulation in the treatment of mild diabetic macular edema (DME)...
  57. pmc Long term functional and structural outcomes of laser therapy for retinopathy of prematurity
    E McLoone
    The Children s Hospital, Temple Street, Dublin 1, Republic of Ireland
    Br J Ophthalmol 90:754-9. 2006
    ..To assess the long term functional and structural outcomes of premature babies who received diode laser photocoagulation for threshold retinopathy of prematurity (ROP)...
  58. ncbi A prospective, comparative study between endoscopic cyclophotocoagulation and the Ahmed drainage implant in refractory glaucoma
    Francisco E Lima
    Federal University of Goias, Goiania, GO, Brazil
    J Glaucoma 13:233-7. 2004
    ..To compare endoscopic cyclophotocoagulation (ECP) and the Ahmed drainage implant in the treatment of refractory glaucoma...
  59. ncbi Bilateral proliferative retinopathy in chronic myelogenous leukemia
    Tony H Huynh
    W K Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor 48105, USA
    Retina 27:124-5. 2007
  60. ncbi Annexin A2 promotes choroidal neovascularization by increasing vascular endothelial growth factor expression in a rat model of argon laser coagulation-induced choroidal neovascularization
    Shi Hong Zhao
    Department of Ophthalmology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Chin Med J (Engl) 123:713-21. 2010
    ..This study aimed to investigate the relationship between annexin A2 (ANXA2) and vascular endothelial growth factor (VEGF) in CNV...
  61. pmc Final visual acuity results in the early treatment for retinopathy of prematurity study
    William V Good
    Smith Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
    Arch Ophthalmol 128:663-71. 2010
    ..To compare visual acuity at 6 years of age in eyes that received early treatment for high-risk prethreshold retinopathy of prematurity (ROP) with conventionally managed eyes...
  62. ncbi Panretinal photocoagulation versus PRP plus intravitreal bevacizumab for high-risk proliferative diabetic retinopathy (IBeHi study)
    Matheus Tonello
    Department of Ophthalmology, School of Medicine of Ribeirao Preto, Ribeirao Preto, Sao Paulo, Brazil
    Acta Ophthalmol 86:385-9. 2008
    ....
  63. ncbi Why do patients still require surgery for the late complications of Proliferative Diabetic Retinopathy?
    P H Scanlon
    Gloucestershire Eye Unit, Cheltenham General Hospital, Cheltenham, UK
    Eye (Lond) 24:435-40. 2010
    ..To briefly review and discuss the literature on why patients still require surgery for the late complications of proliferative diabetic retinopathy (PDR)...
  64. ncbi Combined rhegmatogenous and traction retinal detachment in proliferative diabetic retinopathy: clinical manifestations and surgical outcome
    Chung May Yang
    Department of Ophthalmology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Can J Ophthalmol 43:192-8. 2008
    ..Combined rhegmatogenous and traction retinal detachment (combined detachment) is a serious complication in proliferative diabetic retinopathy. The common clinical findings and surgical results of this complication were investigated...
  65. ncbi Rhegmatogenous retinal detachment in phakic eyes after posterior chamber phakic intraocular lens implantation for severe myopia
    Vicente Martinez-Castillo
    Instituto Oftalmológico de Barcelona, Universidad Autonoma de Barcelona, Barcelona, Spain Vall d Hebrón Hospital, Universidad Autonoma de Barcelona, Barcelona, Spain
    Ophthalmology 112:580-5. 2005
    ..To report the clinical presentation, surgical management, and outcomes of rhegmatogenous retinal detachment (RRD) in patients with severe myopia corrected by posterior chamber phakic (PCP) intraocular lens (IOL) implantation...
  66. ncbi Combined intravitreal injection of triamcinolone acetonide and panretinal photocoagulation for concomitant diabetic macular edema and proliferative diabetic retinopathy
    David N Zacks
    The Retina Service, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Retina 25:135-40. 2005
    ....
  67. ncbi Intravitreal triamcinolone as an adjunct to standard laser therapy in coexisting high-risk proliferative diabetic retinopathy and clinically significant macular edema
    Ahmad Mirshahi
    Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Retina 30:254-9. 2010
    ....
  68. ncbi Posterior sub-Tenon's capsule triamcinolone injection combined with focal laser photocoagulation for diabetic macular edema
    Murat Tunc
    Department of Ophthalmology, Abant Izzet Baysal University Duzce Medical School, Duzce, Turkey
    Ophthalmology 112:1086-91. 2005
    ..To investigate the efficacy of posterior sub-Tenon's capsule triamcinolone injection (PSTI) combined with focal laser (FL) photocoagulation in treatment of diffuse clinically significant diabetic macular edema (CSME)...
  69. ncbi Pigment-epithelium-derived factor is upregulated in photocoagulated human retinal pigment epithelial cells
    Lars Olof Hattenbach
    Klinik fur Augenheilkunde, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Deutschland
    Ophthalmic Res 37:341-6. 2005
    ..According to our results, PEDF mRNA and protein are significantly upregulated after photocoagulation. Moreover, PEDF protein was found to be secreted in the cell culture medium...
  70. ncbi Peripheral retinal nonperfusion associated with chronic myeloid leukemia
    Siamak Nobacht
    Department of Ophthalmology, University Medical Centre, Nijmegen, The Netherlands
    Am J Ophthalmol 135:404-6. 2003
    ..To report a case of peripheral retinal nonperfusion and chronic myeloid leukemia in a 23-year-old woman...
  71. ncbi Panretinal photocoagulation combined with intravitreal bevacizumab in high-risk proliferative diabetic retinopathy
    Won Bin Cho
    Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea
    Retina 29:516-22. 2009
    ..To evaluate the efficacy and safety of intravitreal bevacizumab as an adjunctive treatment to panretinal photocoagulation (PRP) for high-risk proliferative diabetic retinopathy with or without clinically significant macular edema (CSME)...
  72. ncbi Intravitreal injection of pegaptanib sodium for proliferative diabetic retinopathy
    V H Gonzalez
    Valley Retina Institute, PA, McAllen, TX 78503, USA
    Br J Ophthalmol 93:1474-8. 2009
    ..To compare the efficacy of intravitreal pegaptanib (IVP) with panretinal laser photocoagulation (PRP) in the treatment of active proliferative diabetic retinopathy (PDR)...
  73. ncbi Visual acuity after intravitreal triamcinolone for diabetic macular edema refractory to laser treatment: a meta-analysis
    Christopher J Rudnisky
    University of Alberta, Edmonton, Alta
    Can J Ophthalmol 44:587-93. 2009
    ..To quantify the effect on visual acuity of intravitreal triamcinolone for the treatment of laser-refractory diabetic macular edema (DME)...
  74. pmc Intravitreal bevacizumab alone versus combined with macular photocoagulation in diabetic macular edema
    Soo Jeong Lee
    Department of Ophthalmology, Inha University School of Medicine, Incheon, Korea
    Korean J Ophthalmol 25:299-304. 2011
    ..In addtion, changes of DME type were researched using optical coherence tomography...
  75. ncbi Contrast sensitivity as an outcome measure in patients with subfoveal choroidal neovascularisation due to age-related macular degeneration
    J Mones
    Instituto de Microcirugia Ocular de Barcelona, Barcelona, Spain
    Eye (Lond) 19:1142-50. 2005
    ..This paper reviews the evidence for using contrast sensitivity as a measure of visual function and as an outcome measure in clinical trials in patients with subfoveal CNV due to AMD...
  76. ncbi Optimal current and future treatments for diabetic macular oedema
    M S Blumenkranz
    Department of Ophthalmology, Stanford University, Stanford, CA 94305, USA
    Eye (Lond) 24:428-34. 2010
    ..Finally, multi-modality therapy may play an increasingly important role...
  77. ncbi Does laser still have a role in the management of retinal vascular and neovascular diseases?
    Ankur M Shah
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Ophthalmol 152:332-339.e1. 2011
    ..To discuss the current role of laser therapies in the management of retinal vascular and neovascular diseases...
  78. ncbi Saphenous ablation: what are the choices, laser or RF energy
    Nick Morrison
    Morrison Vein Institute, Scottsdale, AZ 85258, USA
    Semin Vasc Surg 18:15-8. 2005
    ..Without this level of commitment, one will be left with poor results and a dissatisfied patient...
  79. ncbi Five-year follow-up of endometrial ablation: endometrial coagulation versus endometrial resection
    Vibeke Hartvig Boujida
    Department of Gynecology and Obstetrics, Holbaek County Hospital, Smedelundsgade 60, DK 4300, Holbaek, Denmark
    Obstet Gynecol 99:988-92. 2002
    ....
  80. ncbi Can optical coherence tomography predict the outcome of laser photocoagulation for diabetic macular edema?
    Elizabeth J Estabrook
    University of Southampton, Southampton, United Kingdom
    Ophthalmic Surg Lasers Imaging 38:478-83. 2007
    ..To assess the outcome of laser photocoagulation in patients with diabetic macular edema...
  81. ncbi Transscleral diode laser retinal photocoagulation for the treatment of threshold retinopathy of prematurity
    Mohammad Mehdi Parvaresh
    Eye Research Center, Iran University of Medical Sciences, Tehran, Iran
    J AAPOS 13:535-8. 2009
    ..To evaluate the outcomes of transscleral diode laser photocoagulation for treatment of threshold retinopathy of prematurity (ROP)...
  82. ncbi Monochorionic twins with selective intrauterine growth restriction and intermittent absent or reversed end-diastolic flow (Type III): feasibility and perinatal outcome of fetoscopic placental laser coagulation
    E Gratacos
    Department of Maternal Fetal Medicine ICGON and Fetal and Perinatal Research Group IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Ultrasound Obstet Gynecol 31:669-75. 2008
    To assess the feasibility and impact on perinatal outcome of fetoscopic laser coagulation of placental anastomoses in monochorionic twins with selective intrauterine growth restriction (sIUGR) and intermittent absent or reversed end-..
  83. ncbi Interstitial laser coagulation versus transurethral resection of the prostate for benign prostatic enlargement--a prospective randomized study
    Fredrik Liedberg
    Department of Urology, Lund University Hospital, Sweden
    Scand J Urol Nephrol 37:494-7. 2003
    Interstitial laser coagulation (ILC) of the prostate is a minimally invasive method for treating symptomatic benign prostatic enlargement (BPE)...
  84. ncbi Pseudoamniotic band syndrome: a rare complication of monochorionic twins with fetofetal transfusion syndrome treated by laser coagulation
    Norbert Winer
    Department of Obstetrics and Gynecology, Université Paris Ouest Versailles St Quentin, Centre Hospitalier Intercommunal Poissy St Germain, Poissy, France
    Am J Obstet Gynecol 198:393.e1-5. 2008
    ....
  85. ncbi A randomised controlled trial comparing the Cavaterm endometrial ablation system with the Nd:YAG laser for the treatment of dysfunctional uterine bleeding
    Jed Hawe
    Department of Obstetrics and Gynaecology, Countess of Chester Hospital, UK
    BJOG 110:350-7. 2003
    ..To compare the effectiveness of the Cavaterm thermal balloon endometrial ablation system with the Nd:YAG laser for the treatment of dysfunctional uterine bleeding...
  86. ncbi Long-term safety, high-resolution imaging, and tissue temperature modeling of subvisible diode micropulse photocoagulation for retinovascular macular edema
    Jeffrey K Luttrull
    Department of Ophthalmology, School of Medicine and Hansen Experimental Physics Laboratory, Stanford University, Palo Alto, California, USA
    Retina 32:375-86. 2012
    ....
  87. ncbi Visual dysfunction after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision
    Masahiko Shimura
    Department of Ophthalmology, NTT East Japan Tohoku Hospital, Miyagi
    Am J Ophthalmol 140:8-15. 2005
    ....
  88. ncbi Accuracy of MR phase mapping for temperature monitoring during interstitial laser coagulation (ILC) in the liver at rest and simulated respiration
    J Heisterkamp
    Department of Surgery, Erasmus University and University Hospital Rotterdam Dijkzigt, The Netherlands
    Magn Reson Med 41:919-25. 1999
    ..The accuracy of magnetic resonance (MR) phase mapping for temperature monitoring of interstitial laser coagulation (ILC) was therefore investigated in two ex vivo models with simulated respiration...
  89. ncbi [Laser coagulation in the treatment of different-type retinopathy of prematures]
    I B Astasheva
    Vestn Oftalmol 121:31-4. 2005
    b>Laser coagulation of the retina was made in 126 children (238 eyes) with retinopathy of prematures (RP) by an 810 nm diode laser ophthalmocoagulator. The methods of transscleral, transpapillary and combined coagulation were applied...
  90. ncbi Ultrastructural analysis of rabbit retina irradiated with a new 670-nm diode red laser at different powers
    Paolo Lanzetta
    Department of Ophthalmology, University of Udine, Udine, Italy
    Retina 25:1039-45. 2005
    ..We verified the structural and ultrastructural effects of diode red laser emissions at 670 nm on pigmented rabbit retina...
  91. ncbi [Combined surgical and pharmacological treatment of diabetic maculopathy]
    Jacek Robaszkiewicz
    Kliniki Okulistycznej Wojskowego Instytutu Medycznego w Warszawie
    Klin Oczna 112:19-23. 2010
    ..Growing body evidence indicates that VEGF acts also on nonvascular cells, it plays survival role on Müller cells and photoreceptors. Therefore anti-VEGF therapies should be administered with caution...
  92. ncbi Durability of probes for interstitial laser coagulation: impact of power setting and probe design
    Oliver Reich
    Department of Urology, Ludwig Maximilians University, Munich, Germany
    J Endourol 18:299-302. 2004
    Interstitial laser coagulation (ILC) is a well-established treatment option for patients suffering from benign prostatic hyperplasia (BPH). The vulnerability of the current fibers adds to the high cost of the procedure...
  93. ncbi Retinal pigment epithelium produces matrix metalloproteinases after laser treatment
    Christina Flaxel
    Glaucoma Service, Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239 4197, USA
    Retina 27:629-34. 2007
    ..To evaluate production of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) after panretinal photocoagulation (PRP) of human retinal pigment epithelium (RPE) explants...
  94. ncbi Growth after intrauterine laser coagulation for twin-twin transfusion syndrome
    C Maschke
    Department of Neonatology, University Childrens Hospital, Adenauerallee 119, Bonn 53113, Germany
    Arch Dis Child Fetal Neonatal Ed 95:F115-7. 2010
    The aim of this study was to investigate prenatal and postnatal growth of twins with twin-twin transfusion syndrome (TTTS) after intrauterine laser coagulation.
  95. ncbi Subthreshold grid laser treatment of macular edema secondary to branch retinal vein occlusion with micropulse infrared (810 nanometer) diode laser
    Maurizio Battaglia Parodi
    Eye Clinic, Azienda Ospedaliero Universitaria di Trieste, Trieste, Italy
    Ophthalmology 113:2237-42. 2006
    ..To compare the effectiveness of subthreshold grid laser treatment (SGLT) with an infrared micropulse diode laser with that of threshold grid laser treatment (TGLT) for macular edema secondary to branch retinal vein occlusion (BRVO)...
  96. ncbi Long-term results of the management of silicone oil-induced raised intraocular pressure by diode laser cycloablation
    S M S Ghazi-Nouri
    Vitreoretinal Research Department, Moorfields Eye Hospital, City Road, London, UK
    Eye (Lond) 19:765-9. 2005
    ..To analyse the effectiveness and safety of cyclodiode treatment in eyes with silicone oil-related raised intraocular pressure (IOP) and to correlate the results with clinical features of treated eyes...
  97. ncbi Modeling of laser coagulation of tissue with MRI temperature monitoring
    Xin Chen
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    J Biomech Eng 132:064503. 2010
    ..This report deals with mathematical modeling and analysis of laser coagulation of tissue...
  98. ncbi Inhibition of laser-induced choroidal neovascularization by atorvastatin by downregulation of monocyte chemotactic protein-1 synthesis in mice
    Kiyoshi Yamada
    Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Invest Ophthalmol Vis Sci 48:1839-43. 2007
    ..To determine the effect of atorvastatin, an HMG CoA reductase inhibitor, on experimental choroidal neovascularization (CNV) induced by laser photocoagulation in mice...
  99. ncbi Magnetic resonance thermometry for predicting thermal damage: an application of interstitial laser coagulation in an in vivo canine prostate model
    R D Peters
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Magn Reson Med 44:873-83. 2000
    ..Results are presented on interstitial laser coagulation of two canine prostate models which are shown to provide an opportunity to evaluate three models of thermal ..
  100. pmc Double masked randomised controlled trial to assess the effectiveness of paracetamol in reducing pain in panretinal photocoagulation
    D Vaideanu
    Sunderland Eye Infirmary, Queen Alexandra Road, Sunderland, UK
    Br J Ophthalmol 90:713-7. 2006
    ..To assess the effectiveness of pre-emptive analgesia with paracetamol in reducing pain associated with panretinal photocoagulation (PRP) in a prospective, double masked, randomised controlled trial...
  101. ncbi Laser treatment of Coats' disease
    Stephen S Couvillion
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Pediatr Ophthalmol Strabismus 42:367-8. 2005
    ..He underwent three sessions of large-spot diode laser for the treatment of Coats' disease. Serial examinations and fundus photography documented an excellent involutional response with an improvement in visual acuity...

Research Grants58

  1. Nonpeptide Somatostatin Agonists for Retinopathy
    Maria Grant; Fiscal Year: 2005
    ..Currently, there is no drug treatment for either DR or ARMD patients, with panretinal laser coagulation surgery as the only option to delay blindness...
  2. Nonpeptide Somatostatin Agonists for Retinopathy
    Gideon Shapiro; Fiscal Year: 2003
    ..Currently, there is no drug treatment for DR patients and pannretinal laser coagulation surgery is the only option to delay blindness...
  3. The Predictive Value of Pre-plus Disease in ROP
    David Wallace; Fiscal Year: 2008
    ..abstract_text> ..
  4. Breast Tissue ablation by Conductive Heating
    Gal Shafirstein; Fiscal Year: 2007
    ..It can also be applied, through further research, to other types of cancers (e.g. lung, kidney, head and neck) that involve surgical resection of solid tumors. [unreadable] [unreadable] [unreadable]..
  5. Endothelial Progenitor Cell Biology in Type 1 Diabetes
    Timothy Crombleholme; Fiscal Year: 2008
    ..3. To determine the mechanisms by which type I diabetes alters EPC gene expression and function. ..
  6. Endothelial Progenitor Cell Recruitment in Diabetic Mice
    Timothy Crombleholme; Fiscal Year: 2008
    ..To determine the mechanisms by which EPCs orchestrate the local angiogenic response by interaction with resident cellular milieu. ..
  7. Endothelial Transmigration Across the RPE Barrier
    Mary Elizabeth Hartnett; Fiscal Year: 2005
    ..Increased knowledge of the mechanisms that cause this destructive phenomenon may lead to future means to prevent CNV in the neurosensory retina, and thus, reduce vision loss in AMD. ..
  8. Twin-Twin Transfusion Syndrome Trial
    Timothy Crombleholme; Fiscal Year: 2004
    ..The overall goal of the study is to improve the outcomes of twins with TTTS by determining which treatment for TTTS has a better survival as well as cardiac, neurologic, and developmental outcome. ..
  9. DERMAL-EPIDERMAL INTERACTIONS IN DIABETIC WOUND HEALING
    Timothy Crombleholme; Fiscal Year: 2004
    ..abstract_text> ..
  10. Chitosan hemostatic device for laparoscopic applications
    Hua Xie; Fiscal Year: 2005
    ..abstract_text> ..
  11. AGE-RELATED MACULAR DEGENERATION PREVENTION TRIAL
    Stuart Fine; Fiscal Year: 2006
    ..In addition, the participating patients will be described with by their scores on both general and vision specific quality of life assessments. ..
  12. Manufacturing Process for Albumin-ICG Solder & Denatured Albumin Scaffold
    Yasmin Wadia; Fiscal Year: 2006
    ..3) Blood conservation by reducing transfusion requirements. 4) Can be used laparoscopically for elective surgeries on liver and kidney. [unreadable] [unreadable]..
  13. Minimally Invasive Surgical Therapies for BPH - Treatme*
    Robert Donnell; Fiscal Year: 2005
    ..In summary, this proposal outlines what we believe to be the outstanding credentials of the Division of Urology, the Medical College of Wisconsin to serve as a clinical center in this multi-institutional trial. ..
  14. Imaging the vascular response to implants
    Jennifer Barton; Fiscal Year: 2006
    ..This aim includes developing miniature probes for intravascular and external use, increasing acquisition speed, and performing signal and image processing to measure perfusion, shear rate, and tissue image texture. ..
  15. Pulsed Electron Avalanche Knife: Intraocular Microsurg.
    Daniel Palanker; Fiscal Year: 2006
    ..The low cost and small size of this system combined with high precision, reliability and versatility should allow for a widespread acceptance into operating practice. ..
  16. Apoptosis in Retinal Detachments
    David Zacks; Fiscal Year: 2006
    ..This will allow us to develop and test new neuroprotective therapies for improving visual outcomes in retinal disease. ..
  17. PROTEOMIC ANALYSIS OF AGE-RELATED MACULAR DEGENERATION
    TONGALP TEZEL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. The Role of Polycystins in the Regulation of Intracellular Calcium and Vascular R
    Qi Qian; Fiscal Year: 2007
    ..The information gained from the proposed study will greatly enhance our understanding in the pathogenesis of vascular complications in ADPKD and provide potential areas for therapeutic targets. [unreadable] [unreadable]..
  19. Statistical Analysis of Longitudinal Medical Cost Data
    Lei Liu; Fiscal Year: 2008
    ..unreadable] [unreadable] Finally, we will develop ready-to-use software to facilitate the application of our methods in practical data analysis. [unreadable] [unreadable] [unreadable]..
  20. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  21. Heart Failure: Epidemiology & Outcomes in the Elderly
    Lesley Curtis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. UGI Hemorrhage and Barrett's Epithelium
    Dennis Jensen; Fiscal Year: 2008
    ..This award will continue to enhance the applicant's research productivity and provide skilled mentoring for young investigators, so they can become independent patient-oriented investigators in digestive diseases. ..
  23. Optical imaging of blood perfusion to predict treatment failure
    Steven Jacques; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Optical Imaging of Ovarian Carcinogenesis in a Rat Menopause Model
    Jennifer Kehlet Barton; Fiscal Year: 2011
    ..abstract_text> ..
  25. Vascular Complications of Polycystic Kidney Disease
    Qi Qian; Fiscal Year: 2007
    ..This period of laboratory based study, plus the formalized career development program, is designed to train the candidate as a physician scientist with a unique expertise in vascular aspects of ADPKD. ..
  26. Telemedical Diagnosis of Retinopathy of Prematurity
    Michael Chiang; Fiscal Year: 2007
    ..Columbia University has a strong existing framework in medical information systems, telemedicine, and public health, which will be leveraged to complete this training and research program successfully. ..
  27. CYTOKINE MODULATION IN PROLIFERATIVE VITREORETINOPATHY
    GLENN JAFFE; Fiscal Year: 2005
    ..Density-dependent effects of IL-1, TNFalpha, and specific NF-kappaB inhibitors on NF-kappaB-mediated RPE apoptosis will be quantified. IV) To determine whether specific in vivo NF-kappaB blockade inhibits PVR. ..
  28. EYE GROWTH DURING INFANCY
    Scott Lambert; Fiscal Year: 2001
    ..In addition, by understanding the mechanisms retarding ocular growth, it may be possible to modulate the excessive ocular growth which occurs in certain pathological conditions such as retinopathy of prematurity. ..
  29. PEDIATRIC LOW VISION
    WILLIAM GOOD; Fiscal Year: 2002
    ..Do strabismus and anisometropia affect different visual functions differentially? Is the combination of risk-factors more amblyogenic? ..
  30. ACTIVE THROMBOSIS, THROMBOLYSIS, AND STROKE OUTCOME
    Brant Watson; Fiscal Year: 2003
    ..Outcome at 3 days, monitored by histological evaluation of regions of frank and incomplete infarction, will be correlated with the time course of reperfusion-inducing treatments and associated molecular changes. ..
  31. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
    ..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
  32. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
  33. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  34. Optical Detection of Barrett's Under Squamous Epithelium
    Michael Kimmey; Fiscal Year: 2003
    ....
  35. The Role of Outer Retinal Injury in Glaucoma
    T Nork; Fiscal Year: 2004
    ..abstract_text> ..
  36. BIOMEDICAL OPTICS FOR MEDICAL RESEARCH AND CLINICAL CARE
    Steven Jacques; Fiscal Year: 2004
    ..The research program complements a Biomedical Optics curriculum. ..
  37. Laser Catheter for Dethrombosis of Arterial Occlusion
    Brant Watson; Fiscal Year: 2005
    ..Finally, we will examine by histologic staining and microscopy the treated portion of the CCA for residual thrombotic material. ..
  38. STUDIES OF BARRETTS ESOPHAGUS
    Gareth Dulai; Fiscal Year: 2005
    ..The applicant has no comparable source of salary for the proposed period of research and training. ..
  39. Control System for MRI Monitored Thermal Therapies
    GARY ZIENTARA; Fiscal Year: 2005
    ....
  40. Array Detectors for Accelerated Small Animal MRI
    James Bankson; Fiscal Year: 2004
    ..This collaborative effort has been established between UTMDACC and Bruker Biospin MRI out of common interest in enhancing throughput using these instruments. ..
  41. OCULAR MELANOMA
    Stuart Fine; Fiscal Year: 2004
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  42. Parallel OCT System for Endoscopic Imaging
    Jennifer Barton; Fiscal Year: 2004
    ..A series of studies will be performed to determine the value of OCT in distinguishing between normal bladder tissue, carcinoma in situ (Tis), and cancer confined to mucosa (Ta) lamina propria (Ti) and muscle (T2)...
  43. VIDEO IMAGING OF SKIN PATHOLOGY USING POLARIZED LIGHT
    Steven Jacques; Fiscal Year: 2001
    ..No human or in vivo animal studies are planned. Phantom tissues composed of polystyrene microspheres and animal tissue samples obtained from the abattoir will be studied. Computer simulations will complement experiments. ..
  44. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2010
    ..Such an approach will provide a rational basis for the development of potentially powerful and effective therapeutics for ocular neovascularization. ..
  45. RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
    Ronald Klein; Fiscal Year: 2002
    ..Data from this study will improve the understanding of the association between microvascular characteristics and cardiovascular mortality. ..
  46. WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
    Ronald Klein; Fiscal Year: 2002
    ....
  47. EARLY TMT RETINOPATHY OF PREMATURITY HEADQUARTER GRANT
    WILLIAM GOOD; Fiscal Year: 2008
    ..Outcome will be determined at a 6 month post-term ophthalmologic examination and at a 9 month post-term visual assessment examination. ..
  48. Fourth NEI Symposium on the Epidemiology of Eye Diseases and Vision Disorders
    Barbara Hawkins; Fiscal Year: 2007
    ..Guest editors from the Planning Committee will be responsible for peer review and other scientific editorial tasks for manuscripts submitted for publication in the special issue of the journal. ..
  49. IMMUNE RESPONSES IN MACULAR DEGENERATION
    Scott Cousins; Fiscal Year: 2009
    ..A new focus will be to test the hypothesis that chronic infection of monocytes with cytomegalovirus is one cause for the development of partially-activated monocytes in some ARMD patients. ..
  50. AGING AND VASCULOGENESIS IN MACULAR DEGENERATION
    Scott Cousins; Fiscal Year: 2006
    ..We will use a combination of bone marrow transplantation, adoptive transfer and depletion techniques to evaluate the role of CD34 vascular progenitors in CNV formation, and how their function changes with aging. ..
  51. The Effects of Prematurity on Visual Development
    WILLIAM GOOD; Fiscal Year: 2008
    ..A comparison of head ultrasound and DTI findings will demonstrate whether DTI should replace ultrasound for the diagnosis of neurological injury in the newborn nursery. [unreadable] [unreadable]..
  52. Novel Risk Factors for Chronic Kidney Disease
    Ronald Klein; Fiscal Year: 2008
    ..The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population. [unreadable] [unreadable] [unreadable]..
  53. Retinal Microvascular Characteristics/Vascular Disorders
    Ronald Klein; Fiscal Year: 2003
    ..abstract_text> ..
  54. OCULAR MELANOMA
    Barbara Hawkins; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  55. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2005
    ..insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities ..
  56. Microvascular - Macrovascular Disease in Type 2 Diabetes
    Ronald Klein; Fiscal Year: 2005
    ....