laparotomy

Summary

Top Publications

  1. pmc Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group Study LAP2
    Joan L Walker
    University of Oklahoma, Oklahoma City, OK 73190, USA
    J Clin Oncol 27:5331-6. 2009
  2. ncbi Safety of laparoscopy versus laparotomy in early-stage endometrial cancer: a randomised trial
    Marian J E Mourits
    Department of Gynaecology, University Medical Center Groningen, University of Groningen, The Netherlands
    Lancet Oncol 11:763-71. 2010
  3. pmc Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia
    Jacobus W A Burger
    Department of General Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Surg 240:578-83; discussion 583-5. 2004
  4. ncbi Peritoneal negative pressure therapy prevents multiple organ injury in a chronic porcine sepsis and ischemia/reperfusion model
    Brian D Kubiak
    Department of Surgery, Upstate University Hospital, Syracuse, New York 13210, USA
    Shock 34:525-34. 2010
  5. ncbi Damage control resuscitation in combination with damage control laparotomy: a survival advantage
    Juan C Duchesne
    Section of Trauma and Critical Care Surgery, Department of Surgery, Emergency Medicine and Anesthesia, Tulane University Health Science Center, New Orleans, Louisiana 70112 2699, USA
    J Trauma 69:46-52. 2010
  6. ncbi Robotic radical hysterectomy: comparison with laparoscopy and laparotomy
    Javier F Magrina
    Division of Obstetrics and Gynecology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, Arizona 85054, USA
    Gynecol Oncol 109:86-91. 2008
  7. pmc Temporary closure of the open abdomen: a systematic review on delayed primary fascial closure in patients with an open abdomen
    Pieter Boele van Hensbroek
    Department of Surgery, Academic Medical Center, P O Box 22660, Room G4 150, 1100 DD, Amsterdam, The Netherlands
    World J Surg 33:199-207. 2009
  8. ncbi Temporary abdominal closure techniques: a prospective randomized trial comparing polyglactin 910 mesh and vacuum-assisted closure
    Tiffany K Bee
    Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Trauma 65:337-42; discussion 342-4. 2008
  9. ncbi Survival and complication rates in 300 horses undergoing surgical treatment of colic. Part 1: Short-term survival following a single laparotomy
    T S Mair
    Bell Equine Veterinary Clinic, Mereworth, Maidstone, Kent ME18 5GS, UK
    Equine Vet J 37:296-302. 2005
  10. pmc Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group LAP2 Study
    Joan L Walker
    University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    J Clin Oncol 30:695-700. 2012

Detail Information

Publications320 found, 100 shown here

  1. pmc Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group Study LAP2
    Joan L Walker
    University of Oklahoma, Oklahoma City, OK 73190, USA
    J Clin Oncol 27:5331-6. 2009
    The objective was to compare laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer.
  2. ncbi Safety of laparoscopy versus laparotomy in early-stage endometrial cancer: a randomised trial
    Marian J E Mourits
    Department of Gynaecology, University Medical Center Groningen, University of Groningen, The Netherlands
    Lancet Oncol 11:763-71. 2010
    ..This study investigated the complication rate of TLH versus TAH in women with early-stage endometrial cancer...
  3. pmc Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia
    Jacobus W A Burger
    Department of General Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Surg 240:578-83; discussion 583-5. 2004
    ..The objective of this study was to determine the best treatment of incisional hernia, taking into account recurrence, complications, discomfort, cosmetic result, and patient satisfaction...
  4. ncbi Peritoneal negative pressure therapy prevents multiple organ injury in a chronic porcine sepsis and ischemia/reperfusion model
    Brian D Kubiak
    Department of Surgery, Upstate University Hospital, Syracuse, New York 13210, USA
    Shock 34:525-34. 2010
    ..Pigs (n = 12) were anesthetized and surgically instrumented for hemodynamic monitoring. Through a laparotomy, the superior mesenteric artery was clamped for 30 min...
  5. ncbi Damage control resuscitation in combination with damage control laparotomy: a survival advantage
    Juan C Duchesne
    Section of Trauma and Critical Care Surgery, Department of Surgery, Emergency Medicine and Anesthesia, Tulane University Health Science Center, New Orleans, Louisiana 70112 2699, USA
    J Trauma 69:46-52. 2010
    Damage control laparotomy (DCL) improves outcomes when used in patients with severe hemorrhage...
  6. ncbi Robotic radical hysterectomy: comparison with laparoscopy and laparotomy
    Javier F Magrina
    Division of Obstetrics and Gynecology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, Arizona 85054, USA
    Gynecol Oncol 109:86-91. 2008
    Comparison of perioperative results of patients undergoing radical hysterectomy by robotics, laparoscopy, and laparotomy.
  7. pmc Temporary closure of the open abdomen: a systematic review on delayed primary fascial closure in patients with an open abdomen
    Pieter Boele van Hensbroek
    Department of Surgery, Academic Medical Center, P O Box 22660, Room G4 150, 1100 DD, Amsterdam, The Netherlands
    World J Surg 33:199-207. 2009
    ..In some cases of abdominal trauma or infection, edema or packing precludes fascial closure after laparotomy. This "open abdomen" must then be temporarily closed. However, the FC rate varies between techniques.
  8. ncbi Temporary abdominal closure techniques: a prospective randomized trial comparing polyglactin 910 mesh and vacuum-assisted closure
    Tiffany K Bee
    Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Trauma 65:337-42; discussion 342-4. 2008
    The options for abdominal coverage after damage control laparotomy or abdominal compartment syndrome vary by institution, surgeon preference, and type of patient...
  9. ncbi Survival and complication rates in 300 horses undergoing surgical treatment of colic. Part 1: Short-term survival following a single laparotomy
    T S Mair
    Bell Equine Veterinary Clinic, Mereworth, Maidstone, Kent ME18 5GS, UK
    Equine Vet J 37:296-302. 2005
    ..Such information is required for owners and veterinary surgeons to make informed decisions about the most appropriate treatment for individual cases...
  10. pmc Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group LAP2 Study
    Joan L Walker
    University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    J Clin Oncol 30:695-700. 2012
    The primary objective was to establish noninferiority of laparoscopy compared with laparotomy for recurrence after surgical staging of uterine cancer.
  11. pmc Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, TX, USA
    Ann Surg 254:598-605. 2011
    To determine whether implementation of damage control resuscitation (DCR) in patients undergoing damage control laparotomy (DCL) translates into improved survival.
  12. ncbi Late fascial closure in lieu of ventral hernia: the next step in open abdomen management
    Preston R Miller
    Department of Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27514, USA
    J Trauma 53:843-9. 2002
    The use of open abdomen techniques in damage control laparotomy and abdominal compartment syndrome has led to development of several methods of temporary abdominal closure...
  13. ncbi Hyaluronate carboxymethylcellulose-based bioresorbable membrane (Seprafilm) reduces adhesion under the incision to make unplanned re-laparotomy safer
    Daisuke Hashimoto
    Department of Surgery, Kumamoto Regional Medical Center, 5 16 10 Honjo, Kumamoto, 860 0811, Japan
    Surg Today 42:863-7. 2012
    ..We conducted this study to assess the effectiveness of the HC membrane in reducing the severity of adhesions in patients undergoing unplanned re-laparotomy.
  14. ncbi Robotic approach for ovarian cancer: perioperative and survival results and comparison with laparoscopy and laparotomy
    Javier F Magrina
    Department of Gynecology, Mayo Clinic in Arizona, USA
    Gynecol Oncol 121:100-5. 2011
    Comparison of perioperative outcomes and survival of patients undergoing primary surgical treatment for epithelial ovarian cancer (EOC) by a robotic, laparoscopy, or laparotomy approach.
  15. ncbi Behavioural effects of laparotomy and analgesic effects of ketoprofen and carprofen in rats
    J V Roughan
    Comparative Biology Centre, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK
    Pain 90:65-74. 2001
    Rat behaviour was studied to develop a reliable method of determining the severity and duration of post-laparotomy pain, and to assess analgesic effects of ketoprofen or carprofen...
  16. ncbi Peritoneal macrophage and blood monocyte functions after open and laparoscopic-assisted cecectomy in rats
    S W Lee
    Division of Colon and Rectal Surgery, New York Presbyterian Hospital, Cornell Weill University, New York, NY 10021, USA
    Surg Endosc 17:1996-2002. 2003
    ....
  17. ncbi Behaviour-based assessment of the duration of laparotomy-induced abdominal pain and the analgesic effects of carprofen and buprenorphine in rats
    J V Roughan
    Comparative Biology Centre, The Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
    Behav Pharmacol 15:461-72. 2004
    ..We have used a behaviour-based pain scoring system to determine the duration of pain resulting from laparotomy, and the duration of analgesia afforded by orally administered (p.o...
  18. ncbi Interrupted or continuous slowly absorbable sutures for closure of primary elective midline abdominal incisions: a multicenter randomized trial (INSECT: ISRCTN24023541)
    Christoph M Seiler
    Study Center of the German Surgical Society, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Ann Surg 249:576-82. 2009
    ..The aim of this study is to compare: (1) interrupted technique with rapidly absorbable sutures and (2) continuous techniques with different slowly absorbable sutures, focusing on the incidence of incisional hernias within 1 year...
  19. ncbi Laparoscopic and open partial nephrectomy: a matched-pair comparison of 200 patients
    Martin Marszalek
    Department of Urology and Andrology, Donauspital, Vienna, Austria
    Eur Urol 55:1171-8. 2009
    ..Laparoscopy is currently challenging the role of the open approach for nephron-sparing surgery (NSS), yet comparative studies on this issue are scant...
  20. ncbi A comparative study of 3 surgical methods for hysterectomy with staging for endometrial cancer: robotic assistance, laparoscopy, laparotomy
    John F Boggess
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Am J Obstet Gynecol 199:360.e1-9. 2008
    ..The purpose of this study was to compare outcomes in women who underwent endometrial cancer staging by different surgical techniques...
  21. ncbi Vacuum-assisted wound closure provides early fascial reapproximation in trauma patients with open abdomens
    G B Garner
    Department of Surgery, University of Texas-Houston Medical School, 6431 Fannin, Suite 4.164, Houston, TX 77030, USA
    Am J Surg 182:630-8. 2001
    ..6 VAWC dressing changes were performed. There were 2 wound infections, no eviscerations, and no enteric fistulas. CONCLUSIONS: Use of VAWC can safely achieve early fascial closure in more than 90% of trauma patients with open abdomens...
  22. ncbi Comparison of on-demand vs planned relaparotomy strategy in patients with severe peritonitis: a randomized trial
    Oddeke Van Ruler
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    JAMA 298:865-72. 2007
    ..with severe secondary peritonitis, there are 2 surgical treatment strategies following an initial emergency laparotomy: planned relaparotomy and relaparotomy only when the patient's condition demands it ("on-demand")...
  23. ncbi Laparoscopy versus laparotomy in endometrial cancer: first analysis of survival of a randomized prospective study
    Roberto Tozzi
    Department of Gynaecologic Oncology, The Royal Marsden Hospital, London, United Kingdom
    J Minim Invasive Gynecol 12:130-6. 2005
    Laparoscopy has been proved to be safe and reliable in staging of patients with endometrial cancer. It has definite advantages over laparotomy, but a comparable survival outcome is still to be verified in prospective randomized trials.
  24. ncbi The impact of patient volume on surgical trauma training in a Scandinavian trauma centre
    Christine Gaarder
    Department of Gastrointestinal Surgery, Ullevaal University Hospital, Kirkeveien 166, 0407 Oslo, Norway
    Injury 36:1288-92. 2005
    ..We wanted to document the experience of trauma team leaders at the largest trauma centre in Norway, hypothesising that the patient volume would be inadequate to secure optimal trauma care...
  25. ncbi Persistent elevation of serum interleukin-6 in intraabdominal sepsis identifies those with prolonged length of stay
    Samir Q Latifi
    Division of Pediatric Pharmacology and Critical Care Medicine, Rainbow Babies and Children s Hospital, Cleveland, OH 44106, USA
    J Pediatr Surg 39:1548-52. 2004
    ..The authors hypothesized that after surgical intervention a persistent elevation of IL-6 would more accurately reflect the inflammatory state and thus predict the subsequent time to recovery better than the preoperative value alone...
  26. ncbi Variables associated with positive findings at relaparotomy in patients with secondary peritonitis
    Oddeke Van Ruler
    Department of Surgery, Academic Medical Center University of Amsterdam, The Netherlands
    Crit Care Med 35:468-76. 2007
    ..No existing scoring system aids in this decisional process. Our aim was to search for variables that could predict positive findings at relaparotomy...
  27. ncbi Laparotomy for visceral ischemia and gangrene
    Karen Woo
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am Surg 73:1006-8. 2007
    ..We retrospectively examined all cases of exploratory laparotomy for suspected bowel ischemia over an 8.5-year period...
  28. ncbi Experience of remifentanil in extremely low-birth-weight babies undergoing laparotomy
    Maria Sammartino
    Department of Anesthesia and Intensive Care, Catholic University of Sacred Heart, Rome, Italy
    Pediatr neonatol 52:176-9. 2011
    ..cases of babies born at 26 weeks' and 27 weeks' gestation, weighing 580 g and 400 g, respectively, undergoing laparotomy for necrotizing enterocolitis. Both received midazolam bolus and remifentanil infusion at high doses...
  29. ncbi Variations in mortality after emergency laparotomy: the first report of the UK Emergency Laparotomy Network
    D I Saunders
    Department of Anaesthesia, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Br J Anaesth 109:368-75. 2012
    Emergency laparotomy is a common intra-abdominal procedure. Outcomes are generally recognized to be poor, but there is a paucity of hard UK data, and reports have mainly been confined to single-centre studies.
  30. ncbi Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: outcomes through 18 months adjusted age
    Martin L Blakely
    University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Pediatrics 117:e680-7. 2006
    ..enterocolitis (NEC) or isolated intestinal perforation (IP) are treated surgically with either initial laparotomy or peritoneal drain placement...
  31. ncbi Open abdomen after trauma and abdominal sepsis: a strategy for management
    William P Schecter
    Department of Surgery, University of California, San Francisco, San Francisco, CA, USA
    J Am Coll Surg 203:390-6. 2006
  32. ncbi Percutaneous catheter decompression in the treatment of elevated intraabdominal pressure
    Michael L Cheatham
    Department of Surgical Education, Orlando Regional Medical Center, 86 W Underwood St, Ste 201, Orlando, FL 32806, USA
    Chest 140:1428-35. 2011
    ..IAH) and abdominal compartment syndrome (ACS) traditionally have been treated surgically through emergent laparotomy. Intensivist-performed bedside drainage of free intraperitoneal fluid or blood (percutaneous catheter ..
  33. pmc Comparison of short-term outcomes between laparoscopically-assisted vs. transverse-incision open right hemicolectomy for right-sided colon cancer: a retrospective study
    Varut Lohsiriwat
    Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    World J Surg Oncol 5:49. 2007
    ..The aim of the study is to compare the short-term surgical outcomes of LRH and open right hemicolectomy through right transverse skin crease incision (ORHT) for right-sided colon cancer...
  34. ncbi Impact of closure at the first take back: complication burden and potential overutilization of damage control laparotomy
    Quinton M Hatch
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:1503-11. 2011
    Damage control laparotomy (DCL) is a lifesaving technique initially employed to minimize the lethal triad of coagulopathy, hypothermia, and acidosis...
  35. ncbi Protocol for bedside laparotomy in trauma and emergency general surgery: a low return to the operating room
    Jose J Diaz
    Section of Surgical Sciences, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    Am Surg 71:986-91. 2005
    Bedside laparotomy (BSL) was introduced as a heroic procedure in trauma patients too unstable for safe transport to the operating room (OR). We hypothesize a BSL protocol would maintain patient safety while reducing OR use...
  36. ncbi Influence of delayed staging laparotomy after laparoscopic removal of ovarian masses later found malignant
    R Lehner
    Department of Obstetrics and Gynecology, University of Vienna, Austria
    Obstet Gynecol 92:967-71. 1998
    To determine whether delayed laparotomy after attempted laparoscopic excision of an ovarian mass later found to be malignant has an impact on the stage of disease.
  37. ncbi Ten-year experience with laparoscopy on a gynecologic oncology service: analysis of risk factors for complications and conversion to laparotomy
    Dennis S Chi
    Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Am J Obstet Gynecol 191:1138-45. 2004
    The purpose of this study was to analyze our initial 10-year experience with laparoscopy and to determine risk factors for complications and conversions to laparotomy for technical difficulty.
  38. pmc Cytokine orchestration in post-operative peritoneal adhesion formation
    Ronan A Cahill
    Department of General Surgery, Cork University Hospital, Wilton, Cork, Ireland
    World J Gastroenterol 14:4861-6. 2008
    Peritoneal adhesions are a near inevitable occurrence after laparotomy and a major cause of both patient and physician misery...
  39. ncbi Clinical predictors of ongoing infection in secondary peritonitis: systematic review
    Bas Lamme
    Department of Surgery, Academic Medical Center, Meibergdreef 9, 1105 AZ, The Netherlands
    World J Surg 30:2170-81. 2006
    ..Predictive variables for positive findings at relaparotomy can generate more objective criteria to support the decision whether to perform a relaparotomy in patients with secondary peritonitis...
  40. ncbi The open abdomen and temporary abdominal closure systems--historical evolution and systematic review
    A J Quyn
    Department of General Surgery, Victoria Hospital, Fife NHS Trust, Kirkcaldy, UK
    Colorectal Dis 14:e429-38. 2012
    ..Several techniques for temporary abdominal closure have been developed. We systematically review the literature on temporary abdominal closure to ascertain whether the method can be tailored to the indication...
  41. ncbi Laparoscopic liver resection: results for 70 patients
    I Dagher
    Department of General Surgery, Antoine Beclere Hospital, Paris Sud School of Medicine, 157 Avenue de la Porte de, Trivaux, 92141, Clamart, France
    Surg Endosc 21:619-24. 2007
    ..The authors report their experience with laparoscopic liver resection, the evolution of the technique, and the results...
  42. ncbi Small intestinal nonmeckelian diverticulosis
    Konstantinos Makris
    Department of Surgery, Metropolitan Hospital, Athens, Greece
    J Clin Gastroenterol 43:201-7. 2009
    ..b>Laparotomy remains the gold standard for definite diagnosis of asymptomatic and complicated diverticula...
  43. ncbi Preventive analgesia is associated with reduced pain disability 3 weeks but not 6 months after major gynecologic surgery by laparotomy
    Joel Katz
    Department of Psychology and School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Anesthesiology 101:169-74. 2004
    ..The purpose of this study was to follow up patients who had received general anesthesia plus epidural fentanyl and lidocaine before (group 1) or after (group 2) incision or general anesthesia plus a sham epidural (group 3)...
  44. ncbi The use of vacuum-assisted closure of abdominal wounds: a word of caution
    M Rao
    Department of Colorectal Surgery, Leeds General Infirmary, Leeds, UK
    Colorectal Dis 9:266-8. 2007
    ..Vacuum-assisted closure (VAC) has been used in our centre to aid the closure of abdominal wounds. The aim of this study was to examine the clinical outcome of patients in whom VAC therapy had been used in conjunction with laparostomy...
  45. ncbi Immediate postoperative pain in orthopedic patients is more intense and requires more analgesia than in post-laparotomy patients
    Margaret P Ekstein
    Department of Anesthesia and Intensive Care Medicine, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pain Med 12:308-13. 2011
    ..To compare the immediate postoperative pain intensity between orthopedic and general surgery patients and evaluate the extent of severe pain in each group...
  46. ncbi Surgical approaches to peritonitis
    M A Boermeester
    Department of Surgery, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Br J Surg 94:1317-8. 2007
  47. ncbi Elective midline laparotomy closure: the INLINE systematic review and meta-analysis
    Markus K Diener
    Department of General, Visceral and Transplantation Surgery, Study Centre of the German Surgical Society, and Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany
    Ann Surg 251:843-56. 2010
    To evaluate the optimal technique and material for abdominal fascia closure after midline laparotomy, first by means of a precisely defined study population and follow-up period and second by the surgically driven aspects.
  48. ncbi Decompressive laparotomy for abdominal compartment syndrome in children: before it is too late
    Erik G Pearson
    Department of Surgery, University of Utah, Salt Lake City, UT 84113, USA
    J Pediatr Surg 45:1324-9. 2010
    ..This underrecognition can result in a critical delay in diagnosis causing increased morbidity and mortality. This study examines the clinical course of patients treated for ACS at our institution...
  49. ncbi A case matched analysis of robotic radical hysterectomy with lymphadenectomy compared with laparoscopy and laparotomy
    Ricardo Estape
    Baptist Health South Florida, South Miami Hospital, Division of Gynecologic Oncology, Miami, FL, USA
    Gynecol Oncol 113:357-61. 2009
    ..To compare robotic radical hysterectomy to laparoscopic and radical abdominal hysterectomy in the treatment of cervical cancer...
  50. ncbi Prognostic factors of the mortality of postoperative intraabdominal infections
    N Torer
    Department of General Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Infection 38:255-60. 2010
    ..We investigated the relationship between the prognostic factors of postoperative peritonitis and mortality...
  51. ncbi Robotic approach for cervical cancer: comparison with laparotomy: a case control study
    Angelo Maggioni
    Gynecology Department, European Institute of Oncology, Milan, Italy
    Gynecol Oncol 115:60-4. 2009
    ..To compare the surgical outcome of robotic radical hysterectomy (RRH) versus abdominal radical hysterectomy (ARH) for the treatment of early stage cervical cancer...
  52. ncbi Laparoscopic surgery vs laparotomy for early stage endometrial cancer: long-term data of a randomized controlled trial
    Fulvio Zullo
    Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Am J Obstet Gynecol 200:296.e1-9. 2009
    The purpose of the study was to compare the long-term safety and efficacy of laparoscopic surgery and laparotomy approaches to early stage endometrial cancer.
  53. ncbi [Relaparotomy in secondary peritonitis Planned relaparotomy or relaparotomy on demand?]
    B Lamme
    Chirurgische Klinik, Academic Medical Center, Amsterdam, Niederlande
    Chirurg 76:856-67. 2005
    ..Criteria for relaparotomy after the initial laparotomy and potential areas for further research to reduce both morbidity and mortality are discussed...
  54. ncbi The incidence and risk factors of post-laparotomy adhesive small bowel obstruction
    Galinos Barmparas
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Los Angeles County Medical Center University of Southern California, 1200 North State Street, Inpatient Tower C Room C5L100, Los Angeles, CA 90033, USA
    J Gastrointest Surg 14:1619-28. 2010
    The purpose of this review was to assess the incidence and risk factors for adhesive small bowel obstruction (SBO) following laparotomy.
  55. ncbi Intestinal perforation as a long-term complication of plug and mesh inguinal hernioplasty: case report
    M Benedetti
    Istituto di Chirurgia Generale e dei Trapianti d Organo Chirurgia Gastroenterologica e Mammaria, IRCCS Policlinico S Matteo Università degli Studi di Pavia, P le Golgi 2, 27100 Pavia, Italy
    Hernia 9:93-5. 2005
    ..We report on a case of sigmoid colon perforation due to a plug of Trabucco hernioplasty performed 2 years previously...
  56. ncbi Laparoscopic conversion rate for uterine cancer surgical staging
    James Fanning
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Pennsylvania State University, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Obstet Gynecol 116:1354-7. 2010
    ..To estimate the conversion rate of attempted laparoscopic staging for primary endometrial adenocarcinoma...
  57. ncbi Closure of the abdominal midline fascia: meta-analysis delineates the optimal technique
    J Rucinski
    Department of Surgery, New York Methodist Hospital and Weill Medical College of Cornell University, Brooklyn 11215, USA
    Am Surg 67:421-6. 2001
    ..A continuous mass (all-layer) closure with absorbable monofilament suture material is the optimal technique for fascial closure after laparotomy.
  58. ncbi Mini-laparotomy implantation of peritoneal dialysis catheters: outcome and rescue
    Po Jen Yang
    Division of General Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    Perit Dial Int 30:513-8. 2010
    ..To correct mechanical outflow obstruction after open surgical methods of catheter insertion, laparoscopic techniques are widely employed. ♢..
  59. ncbi Robot-assisted staging using three robotic arms for endometrial cancer: comparison to laparoscopy and laparotomy at a single institution
    Yong Wook Jung
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Women s Cancer Clinic, Yonsei University College of Medicine, Seoul, Korea
    J Surg Oncol 101:116-21. 2010
    ..To demonstrate the feasibility of robot-assisted staging surgery using three arms in patients with endometrial cancer...
  60. ncbi Learning curve and surgical outcome for robotic-assisted hysterectomy with lymphadenectomy: case-matched controlled comparison with laparoscopy and laparotomy for treatment of endometrial cancer
    Peter C Lim
    Center of HOPE, Renown Regional Medical Center, Department of Gynecological Oncology, 75 Pringle Way, F 11, Reno, NV 89502, USA
    J Minim Invasive Gynecol 17:739-48. 2010
    ..To determine the learning curve for robotic-assisted hysterectomy with lymphadenectomy for surgical treatment of endometrial cancer...
  61. ncbi Damage control laparotomy
    I G Finlay
    Department of General Surgery and Ministry of Defence Hospital Unit, Derriford Hospital, Plymouth, UK
    Br J Surg 91:83-5. 2004
    ..Damage Control Surgery (DCS) is well established in the management of trauma. This study assessed the results of DCS in the management of critically ill patients who had not had trauma...
  62. ncbi The management of the open abdomen in trauma and emergency general surgery: part 1-damage control
    Jose J Diaz
    Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, 1211 21st Avenue South, 404 Medical Arts Building, Nashville, TN 37212, USA
    J Trauma 68:1425-38. 2010
    ..Only damage control is presented in this study. Part 1 is divided into indications for the open abdomen, temporary abdominal closure, staged abdominal repair, and nutrition support of the open abdomen...
  63. ncbi Immunologic postoperative competence after laparoscopy versus laparotomy
    G Bolla
    Department of Surgery, Ospedale Civile of Dolo, Riviera 29 Aprile 2, 30031 DOLO, VE, Venice, Italy
    Surg Endosc 17:1247-50. 2003
    ..immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies...
  64. ncbi Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation
    R Lawrence Moss
    Section of Pediatric Surgery, Yale University School of Medicine, New Haven, Conn 06520 8062, USA
    N Engl J Med 354:2225-34. 2006
    ..We designed this multicenter randomized trial to compare outcomes of primary peritoneal drainage with laparotomy and bowel resection in preterm infants with perforated necrotizing enterocolitis.
  65. ncbi Vertical compared with transverse incisions in abdominal surgery
    T P Grantcharov
    Department of Surgical Gastroenterology, University of Copenhagen, Hvidovre Hospital, Hvidovre, Denmark
    Eur J Surg 167:260-7. 2001
    To reach an evidence-based consensus on the relative merits of vertical and transverse laparotomy incisions.
  66. ncbi Temporary closure of open abdominal wounds by the modified sandwich-vacuum pack technique
    P H Navsaria
    Trauma Unit, Department of Surgery, Groote Schuur Hospital and the University of Cape Town, Cape Town, South Africa
    Br J Surg 90:718-22. 2003
    ..A 5-year experience with the modified sandwich-vacuum pack technique, using an opened 3-litre urological irrigation bag and continuous high-pressure suction, for temporary abdominal wall closure is presented...
  67. ncbi Incisional hernia after open versus laparoscopic sigmoid resection
    Lars Peter Holst Andersen
    Department of Surgical Gastroenterology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
    Surg Endosc 22:2026-9. 2008
    ..Data regarding the long-term hernia risk after laparoscopic colonic surgery are lacking in the literature. In the present study we compared the long-term hernia incidence after laparoscopic versus open sigmoid resection...
  68. ncbi One hundred percent fascial approximation with sequential abdominal closure of the open abdomen
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center, MC 0206, CO 80204, USA
    Am J Surg 192:238-42. 2006
    ..We performed a modification of the vacuum-assisted closure (VAC) technique that provided constant fascial tension, hypothesizing this would result in a higher rate of primary fascial closure...
  69. ncbi Transmural migration of a retained laparotomy sponge
    Jasbir S Dhillon
    Department of Surgery, University of Kentucky, Lexington 40536 0293, USA
    Am Surg 68:603-5. 2002
    The most common surgically retained foreign body is the laparotomy sponge...
  70. ncbi Bodypacking--an increasing problem in The Netherlands: conservative or surgical treatment?
    A A W van Geloven
    Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Surg 168:404-9. 2002
    ..Evaluation of diagnostic work-up and treatment of bodypackers. Identification of predictive factors for surgical treatment...
  71. ncbi Temporary abdominal closure followed by definitive abdominal wall reconstruction of the open abdomen
    Thomas R Howdieshell
    Department of Surgery, Trauma Surgical Critical Care, University of New Mexico Health Sciences Center, MSC10 5610, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Surg 188:301-6. 2004
    Inability to close the abdominal wall after laparotomy for trauma may occur as a result of visceral edema, retroperitoneal hematoma, use of packing, and traumatic loss of tissue...
  72. ncbi Complications after 344 damage-control open celiotomies
    Richard S Miller
    Section of Surgical Sciences, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    J Trauma 59:1365-71; discussion 1371-4. 2005
    ..We reviewed our experience with the open abdomen and hypothesized that the known high wound complication rates were related to the timing and method of wound closure...
  73. ncbi Laparoscopic hysterectomy is preferred over laparotomy in early endometrial cancer patients, however not cost effective in the very obese
    Claudia B M Bijen
    Department of Gynaecology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Cancer 47:2158-65. 2011
    ..In non-randomised data it is often hypothesised that older and obese patients benefit most from TLH. Aim of this study is to analyse whether data support this assumption to advice patients, clinicians and policy makers...
  74. ncbi Smoking is a risk factor for incisional hernia
    Lars Tue Sørensen
    Department of Surgery, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Arch Surg 140:119-23. 2005
    ..Based on previous findings of smoking as a risk factor for wound complications and recurrence of groin hernia, we studied whether smoking is associated with incisional hernia...
  75. ncbi Robot-assisted laparoscopic myomectomy is an improvement over laparotomy in women with a limited number of myomas
    Charles J Ascher-Walsh
    Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY, USA
    J Minim Invasive Gynecol 17:306-10. 2010
    To compare surgical and immediate postoperative results of robot-assisted laparoscopic myomectomy vs myomectomy via laparotomy in patients with 3 myomas or fewer.
  76. ncbi Robotic-assisted hysterectomy for endometrial cancer compared with traditional laparoscopic and laparotomy approaches: a systematic review
    Giorgia Gaia
    Department of Obstetrics and Gynaecology, IRCCS Fondazione Policlinico San Matteo and University of Pavia, Pavia, Italy
    Obstet Gynecol 116:1422-31. 2010
    To summarize comparative studies describing clinical outcomes of robotic-assisted surgeries compared with traditional laparoscopic or laparotomy techniques for the treatment of endometrial cancer.
  77. ncbi Effect of stitch length on wound complications after closure of midline incisions: a randomized controlled trial
    Daniel Millbourn
    Department of Surgery, Sundsvall Hospital, Sundsvall, Sweden
    Arch Surg 144:1056-9. 2009
    ..In midline incisions closed with a single-layer running suture, the rate of wound complications is lower when a suture length to wound length ratio of at least 4 is accomplished with a short stitch length rather than with a long one...
  78. ncbi Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients
    A M Lower
    Isis Fertility Centre, Colchester CO4 9YA, UK
    Hum Reprod 19:1877-85. 2004
    ..This study evaluated the epidemiology of adhesion-related readmissions following open and laparoscopic procedures...
  79. pmc Quality of life of patients with endometrial cancer undergoing laparoscopic international federation of gynecology and obstetrics staging compared with laparotomy: a Gynecologic Oncology Group study
    Alice B Kornblith
    Division of Women s Cancers, Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 27:5337-42. 2009
    The study's objective was to compare the quality of life (QoL) of patients with endometrial cancer undergoing surgical staging via laparoscopy versus laparotomy.
  80. ncbi Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Anesthesiology 101:191-203. 2004
    ..Analgesics display a number of limiting side effects, including sedation, cognitive impairment, and ileus. Although several postoperative rodent models have been developed, these models do not address these concerns...
  81. ncbi How should we treat mucinous appendiceal neoplasm? By laparoscopy or laparotomy? A case report
    G Liberale
    Surgical Department, Institut Jules Bordet, Centre des Tumeurs de l Universite Libre de Bruxelles, Belgique
    Acta Chir Belg 110:203-7. 2010
    ....
  82. ncbi A ten-year review of enterocutaneous fistulas after laparotomy for trauma
    Peter E Fischer
    Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Trauma 67:924-8. 2009
    ..This study is the largest series of ECFs reported exclusively caused by trauma and examines the characteristics unique to this population...
  83. ncbi A case of herniated gravid uterus through a laparotomy scar
    Radha S Rao
    Department of Obstetrics and Gynaecology, Bangalore Medical College, Fort Road, Bangalore 560002, India
    Indian J Med Sci 60:154-7. 2006
    ..Incisional hernia is a frequent complication of abdominal wall closure and the management of pregnancy with a large incisional hernia with gravid uterus in its sac is challenging...
  84. pmc Assessment of post-laparotomy pain in laboratory mice by telemetric recording of heart rate and heart rate variability
    Margarete Arras
    University of Zurich, Institute of Laboratory Animal Science, Zurich, Switzerland
    BMC Vet Res 3:16. 2007
    ..In this study, we investigated the use of telemetry to identify indicators of mild-to-moderate post-laparotomy pain.
  85. ncbi A pilot study comparing percutaneous decompression with decompressive laparotomy for acute abdominal compartment syndrome in thermal injury
    Barbara A Latenser
    Department of Trauma, Cook County Hospital Burn Center, 700 S Wood Street, Chicago, IL, USA
    J Burn Care Rehabil 23:190-5. 2002
    Abdominal Compartment Syndrome (ACS) has multiple causes, and decompressive laparotomy has been the most frequent modality to prevent worsening cardiovascular, respiratory, and renal function...
  86. ncbi Does means of access affect the incidence of small bowel obstruction and ventral hernia after bowel resection? Laparoscopy versus laparotomy
    Hans Joachim Duepree
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Am Coll Surg 197:177-81. 2003
    b>Laparotomy for bowel resection is causally related to the development of small bowel obstruction (SBO) and ventral hernia, with incidences approaching 12% to 15% each...
  87. ncbi Feasibility of laparoscopic debulking with electrosurgical loop excision procedure and argon beam coagulator at recurrence in patients with previous laparotomy debulking
    Huong Trinh
    Department of Obstetrics and Gynecology, Medical College of the Ohio, Toledo, Ohio, USA
    Am J Obstet Gynecol 190:1394-7. 2004
    ..Our purpose is to assess the feasibility and success of laparoscopic ovarian debulking with electrosurgical loop excision procedure (LEEP) and argon beam coagulator (ABC)...
  88. ncbi Damage-control laparotomy
    John C Lee
    Department of Surgery, University of Pittsburgh, UPMC Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Crit Care 12:346-50. 2006
    This article summarizes the current state of damage-control laparotomy as practiced in trauma surgery. Since the first description of deliberately abbreviated laparotomy 20 years ago, damage-control laparotomy has been widely applied...
  89. ncbi Laparoscopic cholecystectomy versus mini-laparotomy cholecystectomy: a meta-analysis of randomised control trials
    Sanjay Purkayastha
    Department of Biosurgery and Surgical Technology, Imperial College, St Mary s Hospital, London, UK
    Surg Endosc 21:1294-300. 2007
    ..To use meta-analytic techniques to compare peri-operative and short term post-operative outcomes for patients undergoing cholecystectomy via the laparoscopic or mini-open approach...
  90. ncbi Laparoscopy versus laparotomy for the surgical management of apparent early stage ovarian cancer
    Fabio Ghezzi
    Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Piazza Biroldi 1, 21100 Varese, Italy
    Gynecol Oncol 105:409-13. 2007
    To compare the results of laparoscopic staging of apparent early ovarian cancer (EOC) with those obtained with comprehensive surgical staging via laparotomy.
  91. ncbi Cytokine response in the postoperative period after surgical treatment of benign adnexal masses: comparison between laparoscopy and laparotomy
    A Torres
    Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20 094, Lublin, Poland
    Surg Endosc 21:1841-8. 2007
    ..study was the comparative assessment in sera of patients with benign adnexal masses treated by laparoscopy or laparotomy of the following proinflammatory and anti-inflammatory cytokines: interleukin (IL)-1beta, IL-6, IL-8, tumor ..
  92. ncbi Surgery of borderline tumors of the ovary: retrospective comparison of short-term outcome after laparoscopy or laparotomy
    Elin Ødegaard
    Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway
    Acta Obstet Gynecol Scand 86:620-6. 2007
    ..Laparoscopic management of borderline ovarian tumors is controversial...
  93. ncbi Transverse versus midline incision for upper abdominal surgery
    Jan Martin Proske
    Department of General, Vascular, Thoracic and Visceral Surgery, Charite, Campus Mitte, Humboldt University Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Surg Today 35:117-21. 2005
    Transverse and midline abdominal incisions are both commonly used for laparotomy to perform surgery on the pancreas and stomach, but comparative data are limited, especially from prospective randomized trials.
  94. ncbi Open-window laparotomy during a transperitoneal approach to the lower lumbar vertebrae: new method for reducing complications
    S Carilli
    General Surgery Department, V K F American Hospital, Istanbul, Turkey
    Minim Invasive Neurosurg 49:227-9. 2006
    ..Isolation of the peritoneal cavity and its contents with this technique can reduce peri- and postoperative abdominal complications...
  95. ncbi Changes in short-term health-related quality of life in women undergoing gynecologic oncologic laparotomy: an associated factor analysis
    Lucas Minig
    Gynecology Department, European Institute of Oncology, Milan, Italy
    Support Care Cancer 21:715-26. 2013
    The primary purpose of this study is to evaluate health-related quality of life (HR-QOL) of gynecologic cancer patients undergoing laparotomy.
  96. pmc Decompressive laparotomy with temporary abdominal closure versus percutaneous puncture with placement of abdominal catheter in patients with abdominal compartment syndrome during acute pancreatitis: background and design of multicenter, randomised, contro
    Dejan V Radenkovic
    Center for Emergency Surgery, Clinical Center of Serbia, University of Belgrade, Serbia
    BMC Surg 10:22. 2010
    ..The aim of DECOMPRESS study was to compare decompresive laparotomy with temporary abdominal closure and percutaneus puncture with placement of abdominal catheter in these patients.
  97. ncbi Comparison of perioperative outcomes and cost of robotic-assisted laparoscopy, laparoscopy and laparotomy for endometrial cancer
    Pluvio J Coronado
    Department of Obstetrics and Gynecology, Hospital Clinico San Carlos, Complutense University of Madrid, Spain
    Eur J Obstet Gynecol Reprod Biol 165:289-94. 2012
    To analyze the perioperative outcomes and cost of three surgical approaches in the treatment of endometrial cancer: robotic, laparoscopy and laparotomy.
  98. ncbi Surgical outcome of robotic surgery in morbidly obese patient with endometrial cancer compared to laparotomy
    Marcus Q Bernardini
    Division of Gynecologic Oncology, Princess Margaret Hospital, Ontario, Canada
    Int J Gynecol Cancer 22:76-81. 2012
    ..surgery at our institution, most obese women of class 2 or greater (body mass index [BMI] >35) underwent a laparotomy for the management of endometrial cancer...
  99. ncbi Safety and efficacy of unidirectional barbed suture in mini-laparotomy myomectomy
    Ming Chao Huang
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Taiwan J Obstet Gynecol 52:53-6. 2013
    To estimate the safety and effectiveness of unidirectional knotless barbed suture compared to the traditional suture for repair of uterine wall defects through myomectomy via mini-laparotomy.
  100. ncbi Influence of laparotomy closure technique on collagen synthesis in the incisional region
    J J Höer
    Surgical University Hospital, Rhenish Westfalian Technical University Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 6:93-8. 2002
    Variations of suture technique have an influence on the mechanical strength of laparotomy wounds...
  101. ncbi Analgesic effects of tramadol, carprofen or multimodal analgesia in rats undergoing ventral laparotomy
    Coralie Zegre Cannon
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Lab Anim (NY) 40:85-93. 2011
    ..carprofen (a nonsteroidal anti-inflammatory drug) and a combination of both drugs (multimodal therapy) in a rat laparotomy model...

Research Grants63

  1. Clinical Development of Hemostatic Agent ClotFoam for Severe Hemorrhage
    Maja Nowakowski; Fiscal Year: 2013
    ..a suitable alternative to open surgery-can be extremely difficult, and often results in conversion to open laparotomy. Intraoperative hemorrhage during liver resection and other laparoscopic procedures remain a major risk which ..
  2. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..biologically significantly attenuate the in vivo immunosuppressive and tumor-enhancing effects of experimental laparotomy and normalize exploratory behavior. Inclusion of females in my experimental designs is a mainstay...
  3. REDUCING LAPAROTOMY WOUND FAILURE
    Sufan Chien; Fiscal Year: 2013
    ..The success of this product will benefit millions of patients who undergo abdominal surgery each year. The usage of this technique may be expanded to other surgical repair procedures and acute wounds. The potential impact is high. ..
  4. RISK FACTORS AS PREDICTORS OF ECTOPIC PREGNANCY
    Kurt T Barnhart; Fiscal Year: 2010
    ..Moreover, an EP of large size is not amenable to medical therapy, may require major surgery (laparotomy) instead of laparoscopy and can cause greater damage to fallopian tube (and greater impairment of fertility), ..
  5. Complex Ventral Hernia Repair
    HOBART WHITAKER HARRIS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ventral hernias occur following 11-23% of laparotomy (abdominal wall) incisions...
  6. Fluorophore-Conjugated Antibodies for Imaging and Resection of GI Tumors
    Meng Yang; Fiscal Year: 2013
    ..cancerous tissue pre-operatively via laparoscopy can eliminate the morbidity from an unnecessary laparotomy and direct subsequent treatment of pancreatic and colon cancer...
  7. Cooperative Multicenter Network of Neontal Intensive Care Units
    Seetha Shankaran; Fiscal Year: 2013
    ..of anesthesia and surgery in contributing to the outcome of ELBW infants participating in the ongoing NRN RCT of Laparotomy versus Drain for Necrotizing Enterocolitis or Isolated Intestinal Perforations and Dr...
  8. Role of mechanical strain in incisional hernia fibroblast function.
    ERIC J CULBERTSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Description: Incisional hernias occur in 7-11% of laparotomy wounds, a substantial health care burden with an annual cost of $2.5 billion. Our laboratory found that a fibroblast wound ...
  9. ENVIRONMENT CHEMICALS AND GYNECOLOGIC HEALTH (ENDO STUDY)
    Matthew Peterson; Fiscal Year: 2009
    ..Approximately 850 women undergoing laparoscopy or laparotomy will be recruited along with approximately 200 women undergoing MRIs from the geographic areas served by the ..
  10. Sutureless Resorbable Anti-Adhesion Films
    MICHAEL J DANILICH; Fiscal Year: 2010
    ..Immediate applications include prevention of adhesions after laparotomy and laparoscopy, but the material can be adapted easily to create a family of adhesives or sealants with ..
  11. Long Term Outcomes of Open Versus Endovascular AAA Repair
    Marc Schermerhorn; Fiscal Year: 2013
    ..of those undergoing endovascular repair;and 3) To rigorously define, quantify, and measure the impact of laparotomy related complications in the case of open AAA repair and graft-related complications in the case of endovascular ..
  12. Minimally Invasive Vaginal Prolapse Repair
    WALTER VON PECHMANN; Fiscal Year: 2012
    ..The current gold standard operation for this disorder is the sacral colpopexy, primarily performed via laparotomy in which a relatively large abdominal incision is made to access the area in a manner similar to that performed ..
  13. Improved Surgical Treatment of Pelvic Organ Prolapse
    KEITH LIPFORD; Fiscal Year: 2009
    ..This procedure is typically performed via laparotomy in which a relatively large abdominal incision is made to access the area in a manner similar to that performed ..
  14. A Shear Force Transfer Coupling for Soft Tissue Repair
    MARK BYRNE; Fiscal Year: 2003
    ..We will use an established wound-healing experimental model: midline laparotomy in New Zealand White rabbits, modified by removal of adjacent fascial sheath...
  15. Radioimmunotherapy: An Anti-Neoplastic Strategy
    Andres Forero; Fiscal Year: 2006
    ..More than 50% of the patients with a laparotomy-confirmed complete response will relapse...
  16. TRIIODOTHYRONINE RECEPTORS AND NONTHYROIDAL DISEASES
    Martin Surks; Fiscal Year: 1990
    ..Walker 256 carcinoma and experimental laparotomy will be used in rats with acute and chronic experimental thyrotoxicosis...
  17. Host response to post-operative pneumonia
    Paul Knight; Fiscal Year: 2005
    ..We predict that laparotomy during influenza will promote the relative expression of MCP-1 and IL-10 over TNFalpha, MIP-2, and IFNgamma...
  18. DEVELOPMENT OF AN MDR-1 RESISTANCE-REVERSAL ASSAY
    John Fruehauf; Fiscal Year: 1993
    ..Patient outcome will be determined at second look laparotomy and correlated to the assay results.
  19. Neonatal Pain, Adult Biobehavioral Responses to Stress
    Gayle Page; Fiscal Year: 2005
    ..prick or paw cotton swab rub 4 times/day on separate paws 1 hour apart, or paw needle prick plus abdominal laparotomy on postnatal day 6, or remain unperturbed...
  20. DOPPLER SCREENING FOR PREGNANCY-INDUCED HYPERTENSION
    Laurence Needleman; Fiscal Year: 1992
    ..Following anesthesia, laparotomy will be performed and pressure and flow meters inserted surgically...
  21. Randomized Trial of EUS Neurolysis in Pancreas Cancer
    Michael Wallace; Fiscal Year: 2006
    ..A 1993 randomized placebo-controlled trial of surgical CRN, performed at the time of exploratory laparotomy, demonstrated CRN to be safe and effective...
  22. PROSPECTIVE CLINICAL STUDIES IN NEONATAL SURGERY
    Martin Blakely; Fiscal Year: 2005
    ..it is anticipated that a randomized trial will be designed near the end of the award period to compare simple peritoneal drainage versus formal laparotomy in infants with NEC, which is a very controversial question in neonatal surgery.
  23. CLINICAL AND BIOLOGICAL BASIS OF 18F-FDG PET IN CANCER
    Yuman Fong; Fiscal Year: 2001
    ..are found to have additional intra-abdominal disease, cannot be resected, and are therefore subjected to a laparotomy for no benefit...
  24. MODULATION OF DRUGS BY PLASMA PROTEINS
    Svein Oie; Fiscal Year: 1991
    ..cultures and in intact animals after induciton of the acute phase response by two different methods; surgery (laparotomy) and ischemia...
  25. NITROGEN POOLS AND TURNOVER IN SURGICAL PATIENTS
    T Stein; Fiscal Year: 1991
    ..II Man. Patients (20) with inflammatory bowel disease on TPN requiring an exploratory laparotomy will be randomized into two groups, G and L...
  26. ENDOSCOPIC INSTRUMENTS FOR CONTROL OF BLEEDING
    DAVID AUTH; Fiscal Year: 1980
    ..must be carefully tested in an adequate number of animals by: (1) application to intact normal gastric mucosa at laparotomy to determine optimal performance parameters; (2) use in laparotomy experiments to determine efficacy and safety ..
  27. ULTRASONIC CHARACTERIZATION OF ABDOMINAL TISSUES
    Frank Sommer; Fiscal Year: 1991
    ..second major clinical project will involve the acquisition of RF data from spleens of patients prior to staging laparotomy to determine the possibility of non-invasive determination of splenic involvement with lymphoma...
  28. COOPERATIVE STUDY OF HODGKIN'S DISEASE
    GEORGE HUTCHISON; Fiscal Year: 1980
    ..in terms of initial characteristics of age, sex, stage of disease, symptomatology, histologic type, use of laparotomy in staging, and use of abdominal radiotherapy fields...
  29. Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Thomas Martin; Fiscal Year: 2009
    ....
  30. Mechanical Failure Induces a Chronic Wound Phenotype in Laparotomy Incisions
    Michael Franz; Fiscal Year: 2009
    b>Laparotomy incisions fail to heal 11% of the time and progress to incisional hernias. Incisional hernia repairs fail to heal 24-58% of the time. Incisional hernias are now the most common complication of abdominal surgery...
  31. Hepatic Arterial Flouridine and IV Bevacizumab for Primary Hepatic Malignancy
    William Jarnagin; Fiscal Year: 2008
    ..Furthermore, several important clinical issues are addressed by the proposed correlative studies, the results of which would be of broad general interest in clinical oncology. [unreadable] [unreadable] [unreadable]..
  32. Videoscopic Drainage of Infected Pancreatic Collections
    Karen Horvath; Fiscal Year: 2004
    ..The long-term goal is to use data obtained from this study as the basis for a multicenter, Phase III, randomized study comparing the VARD to the current standard of care, open surgical necrosectomy. ..
  33. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2009
    ..To investigate this hypothesis, we will examine specific MIP-2-related mechanisms of hepatocyte proliferation and apoptosis following 70% hepatectomy, as well as IP-10's modulating effects in this system. ..
  34. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..These studies will help to elucidate novel mechanisms in SCF-mediated hepatocyte protection and regeneration in a clinically relevant liver resection and toxicity model. ..
  35. Purchase of Ventilated Caging Systems and Workstations
    Debra Hickman; Fiscal Year: 2006
    ..We currently have 5 rooms that house rodents in ventilated filter-top caging but do not have access to a workstation. ..
  36. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2001
    ..abstract_text> ..
  37. TRAUMA-RELATED ERYTHROPOIETIC SUPPRESSION
    David Livingston; Fiscal Year: 2003
    ..Understanding the mechanisms behind post-trauma anemia will allow therapeutic interventions improving endogenous erythropoiesis to be targeted. ..
  38. PERIOPERATIVE PAIN, IMMUNE FUNCTION, AND METASTASIS
    Gayle Page; Fiscal Year: 2001
    ..Fischer 344 males and females in proestrus/estrus and metestrus/diestrus undergo either a standard laparotomy and anesthesia or anesthesia only and receive either the intervention or vehicle...
  39. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
  40. MOLECULAR AND BIOCHEMICAL STUDY OF COLLAGEN IN PROLAPSE
    Anthony Visco; Fiscal Year: 2002
    ..This study would be the first large-scale comprehensive description of collagen cross-linking, lysine hydroxylation, and of genes coding for enzymes involved in the cross-linking process, in patients with pelvic organ prolapse. ..
  41. Targeting Calcium Cycling in a Pre-Clinical Model of Cardiac Dysfunction
    ROGER JOSEPH HAJJAR; Fiscal Year: 2010
    ....
  42. RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 2002
    ..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  43. Regression of cardiac hypertrophy
    ROGER JOSEPH HAJJAR; Fiscal Year: 2010
    ..An understanding of the role of these novel and specific signaling pathways linking events at the level of the membranes to the reversal of hypertrophy would help identify targets for future therapeutic efforts. ..
  44. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2002
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  45. NITRIC OXIDE REGULATORY SYSTEM IN THE PENIS
    Arthur Burnett; Fiscal Year: 2002
    ....
  46. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    ..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
  47. Adenoviral Gene Transfer of Ca2+ ATPase in Heart Failure
    Roger Hajjar; Fiscal Year: 2005
    ....
  48. Discovery of novel fluorescent reporter genes
    Ming Zhao; Fiscal Year: 2004
    ..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
  49. STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLs
    Stephen Nakada; Fiscal Year: 2005
    ..abstract_text> ..
  50. Transgene Induced HIV-Associated Nephropathy
    Vincent Gattone; Fiscal Year: 2004
    ..By studying this HIV-transgenic rat, we should be able to identify additional factors that contribute to the HIV-induced phenotype in GECs and provide new information that will lead to a rational treatment for HIVAN. ..
  51. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2004
    ..We will then test the hypothesis that this novel protocol, by preventing the hypersecretion of luteal products in gonadotropin-induced pregnancies, will result in safer infertility therapy. ..
  52. Management of Chronic Pain in Rehabilitation Medicine
    Mark Jensen; Fiscal Year: 2006
    ..A Scientific Core will provide scientific direction, project coordination, data collection and management, statistical support, and shared scientific expertise. ..
  53. SURGERY FOR NEC IN HUMAN INFANTS-- A RANDOMIZED TRIAL
    R Moss; Fiscal Year: 2002
    ..Traditional surgical therapy includes laparotomy, bowel resection, and creation of intestinal stomas (LAP)...
  54. PDE3 Inhibitors: Selective Blockers of Oocyte Maturation
    Jeffrey Jensen; Fiscal Year: 2007
    ..This approach is expected to provide a foundation for future Phase 1 trials of PDE3 inhibitors in humans. ..
  55. Dual-color tumor-host imaging models
    Meng Yang; Fiscal Year: 2007
    ..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
  56. Prevention of Infection in Indian Neonates
    Pinaki Panigrahi; Fiscal Year: 2006
    ..abstract_text> ..
  57. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
  58. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2008
    ..abstract_text> ..
  59. Pathogenesis of wpk-induced Renal and Cerebral Disease
    Vincent Gattone; Fiscal Year: 2008
    ..abstract_text> ..
  60. TRPV1 Expressing Sensory Afferents in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2009
    ..A separate pathway, likely an A-fiber mediated pathway, is sufficient to transmit the enhanced mechanical responses. ..
  61. PICOT and Cardiac Hypertrophy
    ROGER JOSEPH HAJJAR; Fiscal Year: 2010
    ....