cardiopulmonary bypass

Summary

Summary: Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.

Top Publications

  1. ncbi Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients
    F Roques
    Service de chirurgie cardiovasculaire, CHU de Fort de France, Martinique, France
    Eur J Cardiothorac Surg 15:816-22; discussion 822-3. 1999
  2. ncbi Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction
    Kazuhiro Nakanishi
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Crit Care Med 34:1351-7. 2006
  3. ncbi Surfactant protein B and RAGE increases in the plasma during cardiopulmonary bypass: a pilot study
    P Agostoni
    Centro Cardiologico Monzino, IRCCS, Dept of Cardiovascular Sciences, University of Milan, Milan, Italy
    Eur Respir J 37:841-7. 2011
  4. ncbi Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery
    P Philippidis
    British Heart Foundation Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Circ Res 94:119-26. 2004
  5. pmc Strategies to prevent intraoperative lung injury during cardiopulmonary bypass
    Efstratios E Apostolakis
    Department of Cardiothoracic Surgery, University of Patras, School of Medicine, Patras, Greece
    J Cardiothorac Surg 5:1. 2010
  6. ncbi Meta-analysis of randomised trials comparing the effectiveness of miniaturised versus conventional cardiopulmonary bypass in adult cardiac surgery
    F Biancari
    Division of Cardio Thoracic and Vascular Surgery, Department of Surgery, Oulu University Hospital, Oulu, Finland
    Heart 95:964-9. 2009
  7. ncbi Neutrophil gelatinase associated lipocalin as a biomarker for acute kidney injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass
    A Prabhu
    Department of Biochemistry, MMM Academy of Medical Sciences, Mogapair, Chennai 600037, India
    Ann Vasc Surg 24:525-31. 2010
  8. ncbi Blood phagocyte activation during open heart surgery with cardiopulmonary bypass
    M Pavelkova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, Brno, CZ 612 65, Czech Republic
    Physiol Res 55:165-73. 2006
  9. ncbi The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine
    Serdar Gunaydin
    Department of Pediatric Cardiac Surgery, Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
    Cardiovasc Surg 10:138-45. 2002
  10. ncbi Acute kidney injury after cardiac surgery: focus on modifiable risk factors
    Keyvan Karkouti
    Department of Anesthesia and Health Policy, Management, and Evaluation, Toronto General Hospital, University of Toronto, 200 Elizabeth St, EN 3 402, Toronto, Ontario, Canada M5G 2C4
    Circulation 119:495-502. 2009

Detail Information

Publications314 found, 100 shown here

  1. ncbi Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients
    F Roques
    Service de chirurgie cardiovasculaire, CHU de Fort de France, Martinique, France
    Eur J Cardiothorac Surg 15:816-22; discussion 822-3. 1999
    ..To assess risk factors for mortality in cardiac surgical adult patients as part of a study to develop a European System for Cardiac Operative Risk Evaluation (EuroSCORE)...
  2. ncbi Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction
    Kazuhiro Nakanishi
    Department of Anesthesiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Crit Care Med 34:1351-7. 2006
    To examine the association between decreased release of proinflammatory cytokines in response to urinary trypsin inhibitor pretreatment and decreased myocardial and lung injury after cardiopulmonary bypass.
  3. ncbi Surfactant protein B and RAGE increases in the plasma during cardiopulmonary bypass: a pilot study
    P Agostoni
    Centro Cardiologico Monzino, IRCCS, Dept of Cardiovascular Sciences, University of Milan, Milan, Italy
    Eur Respir J 37:841-7. 2011
    ..b>Cardiopulmonary bypass (CPB) generates a transient lung injury...
  4. ncbi Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery
    P Philippidis
    British Heart Foundation Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Circ Res 94:119-26. 2004
    ..in cardiac surgical patients during the resolution phase of the systemic inflammatory response to cardiopulmonary bypass surgery...
  5. pmc Strategies to prevent intraoperative lung injury during cardiopulmonary bypass
    Efstratios E Apostolakis
    Department of Cardiothoracic Surgery, University of Patras, School of Medicine, Patras, Greece
    J Cardiothorac Surg 5:1. 2010
    During open heart surgery the influence of a series of factors such as cardiopulmonary bypass (CPB), hypothermia, operation and anaesthesia, as well as medication and transfusion can cause a diffuse trauma in the lungs...
  6. ncbi Meta-analysis of randomised trials comparing the effectiveness of miniaturised versus conventional cardiopulmonary bypass in adult cardiac surgery
    F Biancari
    Division of Cardio Thoracic and Vascular Surgery, Department of Surgery, Oulu University Hospital, Oulu, Finland
    Heart 95:964-9. 2009
    The aim of this meta-analysis is to summarise the results of prospective, randomised studies comparing miniaturised (Mini-CPB) versus conventional cardiopulmonary bypass (C-CPB).
  7. ncbi Neutrophil gelatinase associated lipocalin as a biomarker for acute kidney injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass
    A Prabhu
    Department of Biochemistry, MMM Academy of Medical Sciences, Mogapair, Chennai 600037, India
    Ann Vasc Surg 24:525-31. 2010
    ..plasma neutrophil gelatinase associated lipocalin (NGAL) levels as a predictor of renal injury in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) along with markers of oxidative stress.
  8. ncbi Blood phagocyte activation during open heart surgery with cardiopulmonary bypass
    M Pavelkova
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, Brno, CZ 612 65, Czech Republic
    Physiol Res 55:165-73. 2006
    Open heart surgery with a cardiopulmonary bypass (CPB) is associated with a systemic inflammatory response which significantly contributes to adverse postoperative complications...
  9. ncbi The effects of vasoactive intestinal peptide on monocrotaline induced pulmonary hypertensive rabbits following cardiopulmonary bypass: a comparative study with isoproteronol and nitroglycerine
    Serdar Gunaydin
    Department of Pediatric Cardiac Surgery, Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, Japan
    Cardiovasc Surg 10:138-45. 2002
    ..We studied in vivo effects in monocrotaline induced pulmonary hypertensive rabbits immediately after cardiopulmonary bypass (CPB) and tested them versus calcium channel and beta-blockers.
  10. ncbi Acute kidney injury after cardiac surgery: focus on modifiable risk factors
    Keyvan Karkouti
    Department of Anesthesia and Health Policy, Management, and Evaluation, Toronto General Hospital, University of Toronto, 200 Elizabeth St, EN 3 402, Toronto, Ontario, Canada M5G 2C4
    Circulation 119:495-502. 2009
    ..Lacking effective therapies, risk factor modification may offer a means of preventing this complication. The objective of the present study was to identify and determine the prognostic importance of such risk factors...
  11. ncbi Inflammatory response to cardiopulmonary bypass
    Jerrold H Levy
    Department of Anesthesiology, Emory University School of Medicine, Division of Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, Georgia, USA
    Ann Thorac Surg 75:S715-20. 2003
    ..Novel agents are under investigation to further improve outcomes in cardiac surgical patients...
  12. ncbi Computed tomography assessment of lung structure in patients undergoing cardiac surgery with cardiopulmonary bypass
    R R Rodrigues
    Divisão de Anestesia, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Av Enéas C Aguiar 25, Sao Paulo, SP, Brazil
    Braz J Med Biol Res 44:598-605. 2011
    Hypoxemia is a frequent complication after coronary artery bypass graft (CABG) with cardiopulmonary bypass (CPB), usually attributed to atelectasis...
  13. ncbi Continuous mixed venous and central venous oxygen saturation in cardiac surgery with cardiopulmonary bypass
    Pierre Yves Lequeux
    Department of Anesthesiology, Intensive Care Unit, CHU Tivoli, La Louviere, Belgium
    Eur J Anaesthesiol 27:295-9. 2010
    ..The influence of surgery, cardiopulmonary bypass and anaesthesia drugs on the relationship between SvO2 and ScvO2 has never been studied.
  14. ncbi Coagulation disorders of cardiopulmonary bypass: a review
    Domenico Paparella
    Division of Cardiac Surgery, Dipartimento di Emergenza e Trapianti di Organo, University of Bari, Piazza Giulio Cesare 11, 70100 Bari, Italy
    Intensive Care Med 30:1873-81. 2004
    ..Postoperative bleeding is one of the most common complications of cardiac surgery...
  15. pmc Urine and serum microRNA-1 as novel biomarkers for myocardial injury in open-heart surgeries with cardiopulmonary bypass
    Xian Zhou
    Department of Internal Medicine and Anesthesiology and Critical Care Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China
    PLoS ONE 8:e62245. 2013
    ..Open-heart surgeries with cardiopulmonary bypass (CPB) are often accompanied with surgery injury and CPB-associated injury on the hearts...
  16. ncbi Comparing the effects of 5% albumin and 6% hydroxyethyl starch 130/0.4 on coagulation and inflammatory response when used as priming solutions for cardiopulmonary bypass
    Y S Choi
    Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea
    Minerva Anestesiol 76:584-91. 2010
    ..4 in the priming solution for a non-biocompatible cardiopulmonary bypass (CPB) circuit...
  17. pmc Reversal of anemia with allogenic RBC transfusion prevents post-cardiopulmonary bypass acute kidney injury in swine
    Nishith N Patel
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, UK
    Am J Physiol Renal Physiol 301:F605-14. 2011
    Anemia during cardiopulmonary bypass (CPB) is strongly associated with acute kidney injury in clinical studies; however, reversal of anemia with red blood cell (RBC) transfusions is associated with further renal injury...
  18. ncbi Lung dysfunction following cardiopulmonary bypass
    Efstratios Apostolakis
    Department of Cardiothoracic Surgery, University of Patras, School of Medicine, Patras, Greece
    J Card Surg 25:47-55. 2010
    ..The influence mainly of cardiopulmonary bypass (CPB), anesthesia, hypothermia, operation itself, as well as medication and transfusion, can cause a ..
  19. ncbi Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass
    Judith A Hudetz
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Administration Medical Center, Milwaukee, WI, USA
    J Cardiothorac Vasc Anesth 23:651-7. 2009
    To determine if ketamine attenuates postoperative delirium concomitant with an anti-inflammatory effect in patients undergoing cardiac surgery using cardiopulmonary bypass.
  20. ncbi The effect of ulinastatin on postoperative blood loss in patients undergoing open heart surgery with cardiopulmonary bypass
    J E Song
    Department of Anaesthesiology and Pain Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea
    J Int Med Res 39:1201-10. 2011
    ..on postoperative blood loss and transfusion requirements of patients undergoing open-heart surgery with cardiopulmonary bypass (CPB) and aortic cross-clamping (ACC)...
  21. ncbi Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients
    Michael Haase
    Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
    Crit Care Med 35:1324-31. 2007
    ..To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure...
  22. ncbi Subclinical changes in serum creatinine and mortality after coronary artery bypass grafting
    Daniel A Tolpin
    Division of Cardiovascular Anesthesiology, The Texas Heart Institute, St Luke s Episcopal Hospital, Houston, TX 77030, USA
    J Thorac Cardiovasc Surg 143:682-688.e1. 2012
    ..creatinine levels have been used to define acute renal injury in patients undergoing cardiac surgery with cardiopulmonary bypass. It remains unclear, however, whether subclinical increases in serum creatinine that do not meet current ..
  23. ncbi Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin-1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease
    Zhengyuan Xia
    Department of Anesthesiology, Affiliated Renmin Hospital, Wuhan University, PR China
    J Thorac Cardiovasc Surg 126:1404-10. 2003
    The endothelium-derived vasoconstrictor endothelin-1 is increased after cardiopulmonary bypass in children with congenital heart defects...
  24. pmc Surgical treatment of cardiac hydatid disease in 13 patients
    Eylem Tuncer
    Department of Cardiovascular Surgery, Kosuyolu Heart and Research Hospital, 34846 Kartal, Istanbul, Turkey
    Tex Heart Inst J 37:189-93. 2010
    ..All 13 patients underwent sternotomy and surgery under cardiopulmonary bypass. No intraoperative rupture or operative death occurred...
  25. ncbi Microcirculatory alterations in cardiac surgery: effects of cardiopulmonary bypass and anesthesia
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Ann Thorac Surg 88:1396-403. 2009
    Heterogeneity in microvascular perfusion is associated with impaired tissue oxygenation. We hypothesized that cardiac surgery with or without cardiopulmonary bypass (CPB) could induce microvascular alterations.
  26. ncbi Induction of interleukin-19 and interleukin-22 after cardiac surgery with cardiopulmonary bypass
    Chung Hsi Hsing
    Institute of Biopharmaceutical Sciences, Tainan, Taiwan
    Ann Thorac Surg 81:2196-201. 2006
    ..We aimed to analyze if serum levels of these cytokines were altered in inflammatory responses of postoperative cardiopulmonary bypass (CPB) and investigate the molecular mechanism involved in cytokine induction.
  27. ncbi Alterations in inflammatory capacity and TLR expression on monocytes and neutrophils after cardiopulmonary bypass
    Julia S Hadley
    Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Barts and UK
    Shock 27:466-73. 2007
    b>Cardiopulmonary bypass (CPB) is associated with immune paresis, which predisposes to the development of postoperative sepsis...
  28. ncbi Anti-inflammatory effects of alkaline phosphatase in coronary artery bypass surgery with cardiopulmonary bypass
    Suzanne Kats
    Catharina Hospital, Department of Cardiothoracic Surgery, Eindhoven, The Netherlands
    Recent Pat Inflamm Allergy Drug Discov 3:214-20. 2009
    ..and clinical data have implicated endotoxin as an important factor in the inflammatory response to cardiopulmonary bypass. Alkaline phosphatase prevents endotoxin-induced systemic inflammation in animals and humans...
  29. ncbi Simvastatin attenuates cardiopulmonary bypass-induced myocardial inflammatory injury in rats by activating peroxisome proliferator-activated receptor γ
    Yi Shen
    Department of Cardiothoracic Surgery, Jinling Hospital, Clinical Medicine School of Nanjing University, 305 East Zhongshan Road, 210002 Nanjing, China
    Eur J Pharmacol 649:255-62. 2010
    Statins have been shown to downregulate the systemic inflammatory response after cardiopulmonary bypass. However, the role of statins as anti-inflammatory agents in heart tissue remains unknown...
  30. ncbi The effect of biventricular pacing on cardiac function after weaning from cardiopulmonary bypass in patients with reduced left ventricular function: a pressure-volume loop analysis
    Thorsten Hanke
    Department of Cardiac and Thoracic Vascular Surgery, University of Lubeck, Lubeck, Germany
    J Thorac Cardiovasc Surg 138:148-56. 2009
    ..We hypothesized that temporary postoperative atrial synchronous biventricular pacing would improve left ventricular function after cardiopulmonary bypass.
  31. ncbi Morbid results of prolonged intubation after coronary artery bypass surgery
    A J Cohen
    Department of Cardiothoracic Surgery, Wolfson Medical Center, Holon affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Chest 118:1724-31. 2000
    ..This study evaluated the morbid results of prolonged intubation after coronary artery bypass grafting (CABG)...
  32. ncbi Pulmonary abnormalities after cardiac surgery are better explained by atelectasis than by increased permeability oedema
    J Verheij
    Department of Intensive Care, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Acta Anaesthesiol Scand 49:1302-10. 2005
    ..Cardiac surgery can be complicated by pulmonary abnormalities, but it is unclear how various manifestations interrelate...
  33. ncbi Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4
    Brit Dybdahl
    Faculty of Medicine, Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Trondheim, Norway
    Circulation 105:685-90. 2002
    Coronary artery bypass grafting with the use of cardiopulmonary bypass is known to mediate an inflammatory response...
  34. ncbi Cardiac hydatid cysts with intracavitary expansion
    M Kaplan
    Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey
    Ann Thorac Surg 71:1587-90. 2001
    ..Hydatid cyst disease is a significant health problem for undeveloped and developing countries. Although cardiac involvement is rare, early diagnosis and treatment of this situation is important...
  35. ncbi Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass
    Michael G Gaies
    University of Michigan School of Medicine, Ann Arbor, MI, USA
    Pediatr Crit Care Med 11:234-8. 2010
    ..The goal of this study was to determine the association between inotropic/vasoactive support and clinical outcome in infants after cardiac surgery...
  36. pmc Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass
    Catherine D Krawczeski
    The Heart Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Am Coll Cardiol 58:2301-9. 2011
    ....
  37. ncbi Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: a meta-analysis of randomized trials
    Richard P Whitlock
    Division of Cardiac Surgery, McMaster University, Hamilton, Ontario, Canada
    Eur Heart J 29:2592-600. 2008
    We sought to establish the efficacy and safety of prophylactic steroids in adult patients undergoing cardiopulmonary bypass (CPB)...
  38. ncbi The pathophysiology of cardiac surgery-associated acute kidney injury (CSA-AKI)
    R Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Int J Artif Organs 31:166-78. 2008
    ..The duration of cardiopulmonary bypass should be limited whenever possible. Off-pump surgery, when indicated, may decrease the risk of AKI...
  39. ncbi Intestinal ischaemia following cardiac surgery: a multivariate risk model
    Nilanjan Chaudhuri
    Department of Cardiothoracic Surgery, The Cardiothoracic Centre Liverpool, The Cardiothoracic Centre NHS Trust, Thomas Drive, Liverpool L14 3PE, United Kingdom
    Eur J Cardiothorac Surg 29:971-7. 2006
    ..Several studies have examined pre-operative and intra-operative risk factors. We aimed to develop a multivariate risk model to identify those patients at highest risk of intestinal ischaemia...
  40. ncbi [Effects of different doses of ulinastatin on inflammatory response and pulmonary function after cardiopulmonary bypass]
    Xiang you Yu
    Intensive Care Unit, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, Xinjiang, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:664-7. 2009
    ..effect of ulinastatin (UTI) on the changes in inflammatory cytokines and inflammatory response as a result of cardiopulmonary bypass (CPB) in cardiac valvular replacement surgery and to investigate the protective effect of UTI on lungs.
  41. pmc Gastrointestinal complications in patients undergoing heart operation: an analysis of 8709 consecutive cardiac surgical patients
    Abeel A Mangi
    Division of General and Gastrointestinal Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Surg 241:895-901; discussion 901-4. 2005
    ..Systematic analysis of risk factors to allow early identification of patients at risk for GI complication may lead to the development of strategies to mitigate this complication as well as to optimize management after its occurrence...
  42. ncbi Clinically diagnosed nonocclusive mesenteric ischemia after cardiopulmonary bypass: retrospective study
    Hanno Huwer
    Department of Cardiothoracic Surgery, Völklingen Heart Centre, Volklingen Saar, Germany
    Vascular 12:114-20. 2004
    ..study evaluates our experience with clinically diagnosed nonocclusive mesenteric ischemia after cardiopulmonary bypass. Twenty-three of 3,600 consecutive patients suffered from splanchnic malperfusion...
  43. pmc Controlled reoxygenation cardiopulmonary bypass is associated with reduced transcriptomic changes in cyanotic tetralogy of Fallot patients undergoing surgery
    Mohamed T Ghorbel
    Bristol Heart Institute, School of Clinical Science, University of Bristol, Bristol, United Kingdom
    Physiol Genomics 44:1098-106. 2012
    In cyanotic patients undergoing repair of heart defects, high level of oxygen during cardiopulmonary bypass (CPB) leads to greater susceptibility to myocardial ischemia and reoxygenation injury...
  44. pmc Triiodothyronine increases myocardial function and pyruvate entry into the citric acid cycle after reperfusion in a model of infant cardiopulmonary bypass
    Aaron K Olson
    Division of Cardiology, Department of Pediatrics, University of Washington, WA, USA
    Am J Physiol Heart Circ Physiol 302:H1086-93. 2012
    Triiodothyronine (T3) supplementation improves clinical outcomes in infants after cardiac surgery using cardiopulmonary bypass by unknown mechanisms...
  45. ncbi Pulmonary lactate release following cardiopulmonary bypass
    Hrvoje Gasparovic
    Department of Cardiac Surgery, University Hospital Rebro Zagreb, Zagreb, Croatia
    Eur J Cardiothorac Surg 32:882-7. 2007
    The etiology of lung injury following cardiopulmonary bypass (CPB) is multifactorial. Our study focused on quantifying the lactate release from the lungs precipitated by extracorporeal circulation at different time points after the insult...
  46. pmc Cardiopulmonary bypass increases permeability of the blood-cerebrospinal fluid barrier
    Toru Okamura
    Department of Cardiovascular Surgery, Children s National Medical Center, Washington, DC 20010, USA
    Ann Thorac Surg 89:187-94. 2010
    The integrity of the blood-cerebrospinal fluid (CSF) barrier during cardiopulmonary bypass (CPB) with hypothermic circulatory arrest (HCA) has not been systematically studied, especially in children...
  47. ncbi Comparison of urinary biomarkers for early detection of acute kidney injury after cardiopulmonary bypass surgery in infants and young children
    Jianyong Zheng
    Department of Pediatric Cardiology and Cardiac Surgery, Beijing Anzhen Hospital Capital Medical University, No 2 Anzhen Road, Beijing, 100029, People s Republic of China
    Pediatr Cardiol 34:880-6. 2013
    ..Acute kidney injury (AKI) is a potential complication for children with congenital heart disease (CHD) after cardiopulmonary bypass (CPB) surgery...
  48. ncbi Effect of anaesthesia and cardiopulmonary bypass on blood endocannabinoid concentrations during cardiac surgery
    F Weis
    Klinikum Grosshadern, Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    Br J Anaesth 105:139-44. 2010
    ..We sought to study changes in plasma endocannabinoid concentrations during cardiac surgery (CS) under general anaesthesia with isoflurane/sufentanil, and during cardiopulmonary bypass (CPB).
  49. ncbi The acute cardioprotective effect of glucocorticoid in myocardial ischemia-reperfusion injury occurring during cardiopulmonary bypass
    Yavuz Enc
    Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey
    Heart Vessels 21:152-6. 2006
    ..25 mg/kg) in the controlled in vivo model of myocardial ischemia-reperfusion injury occurring during cardiopulmonary bypass. Forty nondiabetic male patients with three-vessel disease undergoing first-time bypass surgery were ..
  50. ncbi Coronary bypass surgery performed off pump does not result in lower in-hospital morbidity than coronary artery bypass grafting performed on pump
    Jean Francois Legare
    Division of Cardiovascular Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Circulation 109:887-92. 2004
    There is increasing evidence that cardiopulmonary bypass (CPB) may be responsible for the morbidity associated with coronary artery bypass grafting (CABG) surgery...
  51. ncbi The preventative role of curcumin on the lung inflammatory response induced by cardiopulmonary bypass in rats
    Kun Liu
    Department of Cardiothoracic Surgery, Jinling Hospital, Clinical Medicine School of Nanjing University, Nanjing, China
    J Surg Res 174:73-82. 2012
    Acute lung injury is a frequent complication after cardiopulmonary bypass (CPB). Recent studies have reported that NF-κB plays an important role in the pathogenesis of post-CPB pulmonary dysfunction...
  52. ncbi Hydroxyethyl starch as a priming solution for cardiopulmonary bypass impairs hemostasis after cardiac surgery
    Anne H Kuitunen
    Department of Anesthesia and Intensive Care Medicine, Helsinki University Central Hospital, Meilahti Hospital, Helsinki, Finland
    Anesth Analg 98:291-7, table of contents. 2004
    We investigated the influence of hydroxyethyl starch (HES) as a priming solution for the cardiopulmonary bypass (CPB) circuit on postoperative hemostasis in 45 patients undergoing elective coronary artery bypass grafting...
  53. ncbi A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass
    Elliott Bennett-Guerrero
    Duke Clinical Research Institute, Duke University, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 23:324-9. 2009
    ..The purpose of this study was to assess the safety of EP administration to patients undergoing higher-risk cardiac surgery and to obtain preliminary efficacy data for the prevention of single and multisystem organ dysfunction...
  54. ncbi Perventricular [correction of Periventricular] closure of ventricular septal defects without cardiopulmonary bypass
    Z Amin
    Department of Cardiovascular Radiology, University of Minnesota, Minneapolis, USA
    Ann Thorac Surg 68:149-53; discussion 153-4. 1999
    Minimally invasive techniques are currently in use to close atrial and ventricular septal defects (VSD). Cardiopulmonary bypass (CPB) is instituted via the femoral vessels, which may cause injury to these vessels, especially in younger ..
  55. ncbi Antioxidant trace element reduction in an in vitro cardiopulmonary bypass circuit
    Charles I McDonald
    Critical Care Research Group, The University of Queensland, The Prince Charles Hospital, Chermside, Australia
    ASAIO J 58:217-22. 2012
    ..It was hypothesized that circulation of blood through the cardiopulmonary bypass (CPB) circuit would 1) reduce trace element levels and antioxidant function, 2) increase oxidative stress, ..
  56. ncbi Genotype and interleukin-10 responses after cardiopulmonary bypass
    H F Galley
    Academic Unit of Anaesthesia and Intensive Care, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Br J Anaesth 91:424-6. 2003
    ..and anti-inflammatory cytokine balance has been implicated in outcome from inflammatory conditions, and cardiopulmonary bypass is associated with a marked inflammatory response...
  57. ncbi Actual knowledge of systemic inflammation reaction during cardiopulmonary bypass
    Asmae Belhaj
    Department of Cardio Pulmonary Transplantation, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik, 808 1070 Brussels, Belgium
    Recent Pat Cardiovasc Drug Discov 7:165-9. 2012
    ..This phenomenon is well described during cardiac surgery under cardiopulmonary bypass but also in the context of off-pump cardiac surhery...
  58. ncbi Large-dose propofol during cardiopulmonary bypass decreases biochemical markers of myocardial injury in coronary surgery patients: a comparison with isoflurane
    Zhengyuan Xia
    Anesthesiology Research Laboratory, Department of Anesthesiology, Renmin Hospital, Wuhan University, 238 Jiefang Rd, Wuhan, 430060, PR China
    Anesth Analg 103:527-32. 2006
    We investigated if increasing propofol's dosage to augment its antioxidant capacity during cardiopulmonary bypass (CPB) could confer cardiac protection...
  59. ncbi Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: should current practice be changed?
    Robert H Habib
    Cardiovascular Surgery, St Vincent Mercy Medical Center, Toledo, Ohio, 43608, USA
    J Thorac Cardiovasc Surg 125:1438-50. 2003
    Hemodilutional anemia during cardiopulmonary bypass can lead to inadequate oxygen delivery and, consequently, to ischemic organ injury...
  60. ncbi Effect of dexamethasone on perioperative renal function impairment during cardiac surgery with cardiopulmonary bypass
    B G Loef
    Cardiothoracic Intensive Care Unit, University Hospital Groningen, Groningen, The Netherlands
    Br J Anaesth 93:793-8. 2004
    In cardiac surgery with cardiopulmonary bypass (CPB), corticosteroids are administered to attenuate the physiological changes caused by the systemic inflammatory response...
  61. ncbi Effect of cardiopulmonary bypass on myocardial function, damage and inflammation after cardiac surgery in newborns and children
    S Hammer
    Department of Paediatric Cardiology and Intensive Care Medicine, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    Thorac Cardiovasc Surg 49:349-54. 2001
    ..and procalcitonin reflects myocardial damage and systemic inflammatory response after cardiac surgery with cardiopulmonary bypass in children...
  62. ncbi The effects of sevoflurane on cerebral blood flow autoregulation and flow-metabolism coupling during cardiopulmonary bypass
    B Reinsfelt
    Department of Cardiothoracic Anaesthesia and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden
    Acta Anaesthesiol Scand 55:118-23. 2011
    ..The effects of sevoflurane on cerebral blood flow (CBF) autoregulation and flow-metabolism coupling during cardiopulmonary bypass (CPB) have not been studied previously.
  63. ncbi Prevention of post-cardiopulmonary bypass acute kidney injury by endothelin A receptor blockade
    Nishith N Patel
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Crit Care Med 39:793-802. 2011
    The aim of this study was to determine whether administration of a specific endothelin A receptor antagonist, sitaxsentan sodium, would prevent the development of post-cardiopulmonary bypass acute kidney injury in swine.
  64. ncbi Coagulation considerations for infants and children undergoing cardiopulmonary bypass
    Michael P Eaton
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Paediatr Anaesth 21:31-42. 2011
    Cardiac surgery involving cardiopulmonary bypass imposes a significant pathophysiologic burden on patients...
  65. ncbi Manual repositioning of intra-atrial kidney cancer tumor thrombus: a technique reducing the need for cardiopulmonary bypass
    Meike Schneider
    Department of Urology, University of Heidelberg, Heidelberg, Germany
    Urology 81:909-14. 2013
    To describe a feasible surgical technique for patients with renal cell carcinoma associated with a supradiaphragmatic tumor thrombus that avoids cardiopulmonary bypass procedure.
  66. ncbi The inflammatory effect of cardiopulmonary bypass on leukocyte extravasation in vivo
    B J Evans
    British Heart Foundation, Cardiothoracic Surgery Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 135:999-1006. 2008
    ..organs is thought to play a major role in the pathophysiologic mechanisms of the inflammatory response to cardiopulmonary bypass, yet leukocyte extravasation is difficult to study clinically...
  67. pmc Inflammatory response and cardioprotection during open-heart surgery: the importance of anaesthetics
    M S Suleiman
    Bristol Heart Institute and Department of Anaesthesia, Faculty of Medicine and Dentistry, Bristol Royal Infirmary, University of Bristol, Bristol, UK
    Br J Pharmacol 153:21-33. 2008
    Open-heart surgery triggers an inflammatory response that is largely the result of surgical trauma, cardiopulmonary bypass, and organ reperfusion injury (e.g. heart)...
  68. ncbi The effect of mannitol on renal function after cardiopulmonary bypass in patients with established renal dysfunction
    M N A Smith
    Department of Anaesthesia, Wessex Cardiothoracic Centre, South Hampton General Hospital, Southampton, UK
    Anaesthesia 63:701-4. 2008
    The usefulness of mannitol in the priming fluid for cardiopulmonary bypass is uncertain in patients with normal renal function, and has not been studied in patients with established renal dysfunction...
  69. ncbi Hippocampus bcl-2 and bax expression and neuronal apoptosis after moderate hypothermic cardiopulmonary bypass in rats
    Ting Jie Zhang
    Department of Anesthesiology, Ren Ji Hospital, Shanghai Second Medicine University, China
    Anesth Analg 102:1018-25. 2006
    Using a rat model of moderate hypothermic (26 degrees C-28 degrees C) cardiopulmonary bypass (CPB) with hemodilution, we investigated hippocampal apoptotic gene expression and neuronal apoptosis up to 6 h after CPB...
  70. ncbi Association of interleukin 18 gene polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery
    S Chen
    Department of Thoracic Surgery, Jiangsu Province Tumor Hospital, Nanjing Medical University, Nanjing, PR China
    Tissue Antigens 76:245-9. 2010
    ..promoter were examined to investigate the association with susceptibility to the development of ALI after cardiopulmonary bypass (CPB) surgery in this study...
  71. ncbi Case report: management of immediate post-cardiopulmonary bypass massive intra-cardiac thrombosis
    Victor M Neira
    Department of Anesthesia HSC 2U1, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Can J Anaesth 54:461-6. 2007
    ..To describe the management of severe acute intracardiac thrombosis in a patient who underwent redo multiple valve replacement and valvular repair. The diagnostic features, associated risk factors, and anesthetic management are reviewed...
  72. pmc Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the Pediatric Health Information Systems database
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 122:2123-30. 2010
    Children undergoing congenital heart surgery often receive corticosteroids with the aim of reducing the inflammatory response after cardiopulmonary bypass; however, the value of this approach is unclear.
  73. ncbi Efficacy and safety of 10% HES 130/0.4 versus 10% HES 200/0.5 for plasma volume expansion in cardiac surgery patients
    C Ertmer
    Department of Anesthesiology, Intensive Care and Pain Therapy, University Hospital of Muenster Muenster, Germany
    Minerva Med 103:111-22. 2012
    ..g., HES 130/0.4, are characterised by improved pharmacological properties. The present study was designed to compare the efficacy and safety of 10% HES 130/0.4 and 10% HES 200/0.5...
  74. ncbi Modifiable and nonmodifiable risk factors for postoperative delirium after cardiac surgery with cardiopulmonary bypass
    Christoph S Burkhart
    Department of Anesthesia and Intensive Care Medicine, University Hospital Basel, Basel, Switzerland
    J Cardiothorac Vasc Anesth 24:555-9. 2010
    ....
  75. ncbi Induced interleukin-19 contributes to cell-mediated immunosuppression in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass
    Ching Hua Yeh
    Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan
    Ann Thorac Surg 92:1252-9. 2011
    Coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) promotes immunosuppression, which predisposes patients to infectious complications...
  76. ncbi Frequency, characteristics, and predictors of microbiologically documented nosocomial infections after cardiac surgery
    Argyris Michalopoulos
    Intensive Care Unit, Henry Dunant Hospital, 107 Mesogeion Ave, 11526 Athens, Greece
    Eur J Cardiothorac Surg 29:456-60. 2006
    ..Nosocomial infections still remain a serious problem in patients undergoing open heart surgery. The objective of this study was to evaluate frequency, characteristics, and predictors of nosocomial infections after cardiac surgery...
  77. ncbi Cyclosporine A prevents apoptosis-related mitochondrial dysfunction after neonatal cardioplegic arrest
    Norihiko Oka
    Division of Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 135:123-30, 130.e1-2. 2008
    ..We tested whether inhibition of mitochondrial permeability transition pore opening with cyclosporine A prevented apoptosis-related alterations in mitochondrial structure and function after cardioplegic arrest...
  78. ncbi Should the "elephant trunk" be skeletonized? Total arch replacement combined with stented elephant trunk implantation for Stanford type A aortic dissection
    Zhi Gang Liu
    Department of Cardiovascular Surgery, Cardiovascular Institute and Fuwai Hospital, Chinese Academe of Medical Science and Peking Union Medical College, Beijing, China
    J Thorac Cardiovasc Surg 131:107-13. 2006
    ....
  79. ncbi Modulation of systemic inflammatory response after cardiac surgery
    Shahzad G Raja
    Department of Cardiac Surgery, Royal Hospital for Sick Children, Yorkhill NHS Trust, Dalnair Street, Glasgow G3 8SJ, Scotland, United Kingdom
    Asian Cardiovasc Thorac Ann 13:382-95. 2005
    Cardiac surgery and cardiopulmonary bypass initiate a systemic inflammatory response largely determined by blood contact with foreign surfaces and the activation of complement...
  80. ncbi Effects of circuit miniaturization in reducing inflammatory response to infant cardiopulmonary bypass by elimination of allogeneic blood products
    Edward Hickey
    Division of Pediatric Cardiac Surgery, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    Ann Thorac Surg 81:S2367-72. 2006
    Conventional neonatal cardiopulmonary bypass requires the use of large volumes of allogeneic blood to prevent unacceptable hemodilution...
  81. ncbi Optimal perfusion during cardiopulmonary bypass: an evidence-based approach
    Glenn S Murphy
    Department of Anesthesiology, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Anesth Analg 108:1394-417. 2009
    In this review, we summarize the best available evidence to guide the conduct of adult cardiopulmonary bypass (CPB) to achieve "optimal" perfusion...
  82. ncbi Increased concentrations of L-lactate in the rectal lumen in patients undergoing cardiopulmonary bypass
    A Perner
    Department of Anaesthesia and Intensive Care, Herlev Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    Br J Anaesth 95:764-8. 2005
    Gut ischaemia may contribute to morbidity in patients after cardiopulmonary bypass (CPB), but little is known about the metabolic state of the large bowel in such patients...
  83. ncbi Effects of insulin therapy on inflammatory mediators in infants undergoing cardiac surgery with cardiopulmonary bypass
    Chun Hu Gu
    Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, 15 Changle West Road, Xi an 710032, Shaanxi, China
    Cytokine 44:96-100. 2008
    ..administration modulates the systemic inflammatory response in infants undergoing cardiac surgery with cardiopulmonary bypass, 60 infants undergoing cardiopulmonary bypass were randomly assigned into a routine therapy group or to an ..
  84. ncbi Temporary biventricular pacing postcardiopulmonary bypass in patients with reduced ejection fraction
    Jochen D Muehlschlegel
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Card Surg 23:324-30. 2008
    ..fraction (EF) undergoing myocardial revascularization frequently require ventricular pacing following cardiopulmonary bypass (CPB)...
  85. ncbi Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial
    Niels Rahe-Meyer
    Clinic for Anesthesiology and Intensive Care Medicine, Franziskus Hospital, Bielefeld, Germany
    Anesthesiology 118:40-50. 2013
    ..The authors assessed whether fibrinogen concentrate can reduce blood transfusion when given as intraoperative, targeted, first-line hemostatic therapy in bleeding patients undergoing aortic replacement surgery...
  86. ncbi Off-pump versus on-pump coronary artery revascularization: effects on pulmonary function
    Ana M R P e Silva
    Department of Surgery, Santa Casa de Sao Paulo, Faculty of Medical Sciences, Sao Paulo, Brazil
    Interact Cardiovasc Thorac Surg 11:42-5. 2010
    ..The results suggest that different changes occur in pulmonary function when the surgery is performed with or without cardiopulmonary bypass. The off-pump patients showed significantly greater improvement than the on-pump group.
  87. pmc Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Biomarkers 14:423-31. 2009
    ..lipocalin (NGAL), interleukin (IL)-18, cystatin C and alpha-1 microglobulin, measured 2 h following cardiopulmonary bypass (CPB) for the early detection of acute kidney injury (AKI) in a prospective cohort of patients undergoing ..
  88. ncbi Comparative assessment of coagulation changes induced by two different types of heart-lung machine
    Niels Rahe-Meyer
    Department of Anesthesiology, Hannover Medical School, Hannover, Germany
    Artif Organs 34:3-12. 2010
    The cardiopulmonary bypass (CPB) used in heart surgery has a deleterious effect on hemostasis...
  89. ncbi Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: a pilot randomized, double-blind, placebo-controlled trial
    Adnan T Bhutta
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Pediatr Crit Care Med 13:328-37. 2012
    Infants are potentially more susceptible to cell death mediated via glutamate excitotoxicity attributed to cardiopulmonary bypass. We hypothesized that ketamine, via N-methyl D-aspartate receptor blockade and anti-inflammatory effects, ..
  90. pmc Plasma acetate, gluconate and interleukin-6 profiles during and after cardiopulmonary bypass: a comparison of Plasma-Lyte 148 with a bicarbonate-balanced solution
    Paul G Davies
    DDepartment of Anaesthesia, Princess Alexandra Hospital, University of Queensland, Ipswich Road, Woolloongabba, QLD 4102, Australia
    Crit Care 15:R21. 2011
    ..No published data exist on the peak plasma acetate and gluconate concentrations resulting from the use of Plasma-Lyte 148 during CPB...
  91. ncbi Fibrin formation is more impaired than thrombin generation and platelets immediately following cardiac surgery
    Cristina Solomon
    Department of Anaesthesiology and Intensive Care, Salzburger Landeskliniken SALK, Salzburg, Austria
    Thromb Res 128:277-82. 2011
    ..The effects of haemostatic therapy with fresh frozen plasma (FFP) and platelet concentrate on these parameters were also evaluated...
  92. ncbi Tumor necrosis factor-alpha production in whole blood after cardiopulmonary bypass: downregulation caused by circulating cytokine-inhibitory activities
    J Borgermann
    Department of Cardiac and Thoracic Surgery, Martin Luther University Halle Wittenberg, Halle Saale, and the Department of Surgery, Clinical Research Group Shock and MOF, University Hospital of Essen, Essen, Germany
    J Thorac Cardiovasc Surg 124:608-17. 2002
    b>Cardiopulmonary bypass is associated with the release of proinflammatory cytokines (tumor necrosis factor alpha, interleukin 1beta, interleukin 6, and interleukin 8) and anti-inflammatory cytokines (interleukin 10 and transforming growth ..
  93. ncbi A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery
    Shahid M Nimjee
    University Program in Genetics and Genomics, Duke University Medical Center, Durham, NC 27710, USA
    Mol Ther 14:408-15. 2006
    Heparin and protamine are the standard anticoagulant-antidote regimen used in almost every cardiopulmonary bypass (CPB) procedure even though both are associated with an array of complications and toxicities...
  94. ncbi Prevention of TNFalpha-associated myocardial dysfunction resulting from cardiopulmonary bypass and cardioplegic arrest by glucocorticoid treatment
    Oliver J Liakopoulos
    Department of Thoracic and Cardiovascular Surgery, University of Gottingen, Germany
    Eur J Cardiothorac Surg 30:263-70. 2006
    Cardiac surgery on cardiopulmonary bypass (CPB) results in progressive myocardial dysfunction, despite unimpaired coronary blood flow, and is associated with increased myocardial tumor necrosis factor-alpha (TNFalpha) expression...
  95. ncbi Activation of the hemostatic system during cardiopulmonary bypass
    Roman M Sniecinski
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia, Emory University School of Medicine, Atlanta, Georgia, USA
    Anesth Analg 113:1319-33. 2011
    b>Cardiopulmonary bypass (CPB) is a unique clinical scenario that results in widespread activation of the hemostatic system...
  96. ncbi Impact of different pacing modes on left ventricular function following cardiopulmonary bypass
    O Dzemali
    Department for Cardiothoracic Surgery, J W Goethe University Hospital, Frankfurt am Main, Germany
    Thorac Cardiovasc Surg 56:87-92. 2008
    ..This prospective study investigates hemodynamic effects and outcomes of perioperative temporary biventricular pacing in patients with heart failure undergoing heart surgery...
  97. ncbi Dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass
    Todd M Umstead
    Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Pediatr Res 67:641-9. 2010
    Plasma samples from pediatric cardiac patients undergoing cardiopulmonary bypass (CPB) procedures were used to identify and characterize patterns of changes in potential biomarkers related to tissue damage and inflammation...
  98. ncbi Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-alpha, IL-6, IL-8, IL-10
    Jale Bengi Celik
    Department of Cardiovascular Surgery, Meram Medical School of Selcuk University, Meram, Konya, Turkey
    Perfusion 19:185-91. 2004
    ..This study examined the correlation between tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-8, IL-10 and methylprednisolone pretreatment...
  99. ncbi The inflammatory response to colloids and crystalloids used for pump priming during cardiopulmonary bypass
    E Tamayo
    Department of Anaesthesiology and Reanimation, Valladolid University Hospital, Valladolid, Spain
    Acta Anaesthesiol Scand 52:1204-12. 2008
    ..This study tests the hypothesis that the priming of the extracorporeal circuit with colloid solutions results in less inflammation in patients undergoing cardiac surgery than priming with crystalloid solutions...
  100. ncbi Measurement of cardiac output before and after cardiopulmonary bypass: Comparison among aortic transit-time ultrasound, thermodilution, and noninvasive partial CO2 rebreathing
    Monica Botero
    Department of Anesthesiology, University of Florida College of Medicine and the Gainesville Veterans Affairs Medical Center, Gainesville, FL, USA
    J Cardiothorac Vasc Anesth 18:563-72. 2004
    ..this study was to compare the agreement among NICO, bolus (TDCO), and continuous thermodilution (CCO), with transit-time flowmetry of the ascending aorta using an ultrasonic flow probe (UFP) before and after cardiopulmonary bypass (CPB).
  101. ncbi Prospective study on cardiopulmonary bypass prime reduction and its effect on intraoperative blood product and hemoconcentrator use
    Michael A Sobieski
    Division of Cardiac Surgery, Advocate Christ Medical Center, Oak Lawn, IL, USA
    Perfusion 20:31-7. 2005
    Evaluate the feasibility and clinical significance of crystalloid prime reduction during the initiation of cardiopulmonary bypass (CPB) using a modified bridge on the cardioplegia delivery system.

Research Grants72

  1. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009
    ..morbidity and to prolongation of hospital stay, complicates 20 40% of surgical procedures requiring cardiopulmonary bypass. While recent randomized clinical trials indicate interruption of the renin-angiotensin-aldosterone system ..
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..tissues or organs has deleterious consequences in various clinical settings such as thrombolytic therapy, cardiopulmonary bypass, organ transplantation, and acute percutaneous coronary angioplasty...
  3. Right ventricular contractile dysfunction after pressure overload
    CLIFFORD RUSSELL GREYSON; Fiscal Year: 2013
    ..in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation, but effective therapeutic strategies are not currently available...
  4. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..IRI is a detrimental feature of many clinical events such as organ transplants, cardiopulmonary bypass (CPB) used in cardiac surgery, myocardial infarction (MI), and stroke...
  5. Clinical and genomic responses to remote ischemic preconditioning
    Brian W McCrindle; Fiscal Year: 2010
    The use of cardiopulmonary bypass for cardiac surgery in children results in important morbidity and sometimes mortality related to the adverse effects of bypass induced by hypothermia, hemolysis, acid-base management, hemodilution and ..
  6. Research Center for Pharmacology &Drug Toxicology
    L Jackson Roberts; Fiscal Year: 2013
    ..of acetaminophen to inhibit hemoglobin and myoglobin induced oxidative stress in patients undergoing cardiopulmonary bypass surgery...
  7. Effect of cardioplegia and cardiopulmonary Bypass on coronary microvascular react
    Frank W Sellke; Fiscal Year: 2013
    ..This is especially true after heart operations involving cardiopulmonary bypass (CPB)...
  8. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    William Brown; Fiscal Year: 2009
    ..We will investigate air emboli introduced into the cardiopulmonary bypass (CPB) circuit in two locations, in three forms: air in the venous cannula; agitated air in water in the ..
  9. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    David Stump; Fiscal Year: 2013
    ..We will investigate air emboli introduced into the cardiopulmonary bypass (CPB) circuit in two locations, in three forms: air in the venous cannula;agitated air in water in the ..
  10. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..ACD) proposed here affords a very effective ventricular decompression and unloading without requiring cardiopulmonary bypass or a sternotomy. The role of VADs has evolved since their clinical introduction...
  11. Vascular and Neural Mechanisms of Serotonin-induced Reduction in Blood Pressure
    Stephanie W Watts; Fiscal Year: 2013
    ..These include anaphylactic shock, cardiopulmonary bypass, carcinoid cancer and hemodialysis, all of which presents with a fall in blood pressure...
  12. A NEW TECHNIQUE FOR TREATING HEMORRHAGIC SHOCK
    Sufan Chien; Fiscal Year: 2013
    ..may also benefit various clinical conditions, such as coronary heart disease, stroke, spinal cord injury, cardiopulmonary bypass, organ transplant, chronic wounds, and many other conditions where ischemia is involved...
  13. Novel Biomarkers Predictive of Heparin-Induced Thrombocytopenia
    Barbara A Konkle; Fiscal Year: 2010
    ..increased risks of bleeding and increased costs, and have not replaced UFH for common surgeries requiring cardiopulmonary bypass (CPB)...
  14. The effect of TLR4 inhibition on lung transplant ischemia-reperfusion injury
    PERRY ARTHUR GENOVA; Fiscal Year: 2010
    ..IRI is also a major problem in many clinical scenarios, including cardiopulmonary bypass (CPB) used in cardiac surgery, myocardial infarction (MI), and stroke...
  15. Excitotoxicity in Circulatory Arrest ? Brain Injury
    WILLIAM ANTHONY BAUMGARTNER; Fiscal Year: 2012
    ..work in which we have investigated the mechanisms of neurologic injury in a clinically relevant model of cardiopulmonary bypass (CPB) and HCA...
  16. Effects of glycemic control on immunity
    Thomas P Shanley; Fiscal Year: 2012
    Abstract: Cardiopulmonary bypass (CPB) is necessary to repair complex congenital heart disease (CHD), but also contributes to the morbidity and mortality in children surviving surgical repair...
  17. GENES AND FIBRINOLYTIC CAPACITY OF HUMAN ENDOTHELIUM
    Mias Pretorius; Fiscal Year: 2012
    ..in the human forearm vasculature and contributes to the fibrinolytic and inflammatory response to cardiopulmonary bypass, a procedure similar to hemodialysis in terms of blood-membrane interactions...
  18. Protection of Developing White Matter during Cardiac Surgery
    Richard A Jonas; Fiscal Year: 2013
    ..causative factors of WMI in the newborn include a unique susceptibility to the deleterious effects of cardiopulmonary bypass (CPB) including an exaggerated systemic inflammatory response as well as a risk of ischemia/reperfusion...
  19. Hepcidin Lateral Flow Device for Prediction of Acute Kidney Injury
    MARK EDWARD WESTERMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute kidney injury (AKI) is a common, severe complication of cardiopulmonary bypass (CPB) assisted surgeries, and include coronary artery bypass grafts, valve replacements, aortic aneurisms, and ..
  20. Brain metabolism and neuroprotection in cardiopulmonary bypass
    Anna Pastuszko; Fiscal Year: 2012
    ..Support techniques integral to cardiac surgery include cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA)...
  21. Preoperative Therapy for Prevention of Postoperative Low Cardiac Output Syndrome
    D Woodrow Benson; Fiscal Year: 2010
    ..LCOS remains an important clinical problem with an estimated incidence of ~25% in infants undergoing cardiopulmonary bypass. This application proposes a multi-center, randomized, double blind, placebo-controlled clinical trial, to ..
  22. Antithrombotic Aptamers and Antidotes
    BRUCE ALAN SULLENGER; Fiscal Year: 2013
    ..3) To determine which anticoagulant aptamers can effectively inhibit coagulation in the setting of cardiopulmonary bypass surgery and determine if oligonucleotide and universal antidotes can rapidly and safely reverse the ..
  23. Perinatal Pulmonary Hypertension: Developmental Mediators
    Jeffrey R Fineman; Fiscal Year: 2013
    ..pulmonary vascular disease, however perioperative pulmonary vascular dysfunction, particularly following cardiopulmonary bypass (CPB), continues to contribute to the morbidity and mortality of these patients...
  24. Continuous monitoring of anti-fibrinolytic therapy in cardiovascular surgery
    Francis G Spinale; Fiscal Year: 2012
    ..to demonstrate the application and utility of this validated prototype in a large animal model of cardiopulmonary bypass. The outcomes from the technology refinement and animal testing will be a complete system that can be ..
  25. Randomized Clinical Trials for Pediatric Heart Disease
    J Philip Saul; Fiscal Year: 2010
    ..Protocol: Randomized Trial of Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass (CPB)...
  26. Neurodevelopmental Outcomes in Infants with HLHS after Hybrid Stage I Palliation
    Sharon L Hill; Fiscal Year: 2011
    ..are performed during the first 2-3 years of life, requiring profound hypothermic circulatory arrest and cardiopulmonary bypass. Neurodevelopmental outcomes in this cohort of patients remain suboptimal...
  27. Metabolism During Mechanical Circulatory Support in the Developing Heart
    Michael A Portman; Fiscal Year: 2013
    ..homeostasis, such as decreases in circulating levels of thyroid hormones, occur during both shorter term cardiopulmonary bypass (CPB) and longer term ECMO...
  28. Efficacy of Kunitz Domain 1 variants of TFPI-2 as novel antifibrinolytic agents
    MADHU SATYA BAJAJ; Fiscal Year: 2010
    ..In fact, aprotinin was the only FDA-approved drug to reduce blood transfusion in cardiac surgery with cardiopulmonary bypass. Three meta-analyses of aprotinin reported in 1999 indicated that aprotinin decreased mortality (by two ..
  29. Determining the Effect of Altered Pulse Pressure on Artery Structure and Function
    DANIKA HAYMAN; Fiscal Year: 2010
    ..Conversely, pulse pressure decreases with the use of axial flow left ventricular assist devices and cardiopulmonary bypass machines, which have been shown to alter systemic vascular behavior...
  30. Cerebral Autoregulation Monitoring to Reduce Brain Injury from Cardiac Surgery
    OLA ARVID SELNES; Fiscal Year: 2013
    ..current practices of targeting low mean arterial blood pressure empirically (usually 50-70 mmHg) during cardiopulmonary bypass may expose patients with impaired cerebral autoregulation to cerebral hypoperfusion...
  31. S1P Deficiency Prolongs Endothelial Barrier Recovery After Fontan Operation
    SINAI CHOI ZYBLEWSKI; Fiscal Year: 2013
    ..experience derangements in vascular permeability secondary to the profound inflammatory effects of cardiopulmonary bypass (CPB)...
  32. Apical Access System with Universal Connector for Beating Heart LVAD Implantation
    Jorge Hernan Jimenez; Fiscal Year: 2013
    ..to be implanted suture-less through a minimally invasive incision without placing the patient on cardiopulmonary bypass (CPB)...
  33. INTRACELLULAR ENERGY DELIVERY AND DIABETIC WOUNDS
    Sufan Chien; Fiscal Year: 2010
    ..wound care, but also help our treatment to various ischemic conditions, such as severe trauma, shock, stroke, heart attack, spinal cord injury, cardiopulmonary bypass, organ transplant, and many other acute and chronic ischemic diseases.
  34. Activation of clotting & cell adhesion: gas embolism
    David M Eckmann; Fiscal Year: 2010
    Vascular gas embolism contributes to cerebral dysfunction in over 300,000 cardiopulmonary bypass patients in the US annually. Transient and permanent brain abnormalities occur...
  35. Small heat shock proteins in surgically-induced myocardial stunning
    Richard T Clements; Fiscal Year: 2012
    The majority of coronary artery bypass grafting (CABG) and valve repair surgeries use cardioplegia and cardiopulmonary bypass (CP/CPB) to respectively arrest the heart and systemically circulate oxygenated blood...
  36. Neurodevelopmental Outcome after Cardiac Intensive Care
    DAVID LLOYD WESSEL; Fiscal Year: 2013
    ..Neonates undergoing cardiac surgery requiring cardiopulmonary bypass will have NIRS monitoring preoperatively, intraoperatively and postoperatively...
  37. University of Montreal Cardiac Surgery Clinical Investigation Group
    LOUIS PAUL PERRAULT; Fiscal Year: 2013
    ..treatment option for severe ischemic mitral regurgitation and a second project test a new pharmacological management of pulmonary hypertension in patients experiencing difficult separation from cardiopulmonary bypass. (End of Abstract)
  38. Etiologic and therapeutic studies of heparin-induced thrombocytopenia (HIT)
    Mortimer Poncz; Fiscal Year: 2011
    ..Around half of heparinized patients develop such antibodies after cardiopulmonary bypass (CPB), yet only 1-5% of them develop HIT...
  39. Inhibition of Cardiac Device Induced Cellular Dysfunction in Pigs
    REKHA BANSAL; Fiscal Year: 2012
    ..We would like to extend these novel findings utilizing a pig model of cardiopulmonary bypass with an induced occlusion of the descending coronary artery to mimic the clinical setting...
  40. Clinical Significance of protamine/heparin antibodies after CPB
    Gowthami M Arepally; Fiscal Year: 2012
    ..PRT) sulfate is the only commercially approved therapy for the reversal of heparin anticoagulation after cardiopulmonary bypass (CPB)...
  41. Pediatric Heart Network Prairieland Consortium
    Catherine Dent Krawczeski; Fiscal Year: 2013
    ..Acute kidney injury (AKI) is a common complication of cardiopulmonary bypass (CPB), affecting adult and pediatric patients and significantly increasing the risk of mortality and ..
  42. Randomized, placebo-controlled, double-blind trial of T3 in infant heart surgery
    Jane W Newburger; Fiscal Year: 2010
    ..applicant): Sick euthyroid syndrome is common among infants and children following cardiac surgery using cardiopulmonary bypass. Recent data suggest that triiodothyronine (T3) supplementation after cardiac surgery may improve ..
  43. ADHD (Attention Deficit Hyperactivity Disorder) after Surgery for Congenital Hear
    Victoria L Vetter; Fiscal Year: 2010
    ..1) to determine the prevalence of ADHD in the population of children with CHD undergoing surgery using cardiopulmonary bypass in infancy or early childhood;2) to compare the prevalence rates of ADHD associated with age of exposure ..
  44. SUMO Conjugation and Deep Hypothermia-Induced Organ Protection
    Wulf Paschen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Various pediatric and adult cardiovascular operations involve cardiopulmonary bypass (CPB) procedures that require a period of circulatory arrest...
  45. Development of transapical MVAD for heart failure therapy
    Daniel Tamez; Fiscal Year: 2013
    ..It requires a major operative intervention, arrested heart with cardiopulmonary bypass (CPB), and blood component exposure, which have been associated with significant adverse event rates and ..
  46. Hybernia Safety Catheter for Neuroprotection via Selective Hypothermia
    JOHN MARTIN PILE-SPELLMAN; Fiscal Year: 2011
    ..Hypothermia is a powerful neuroprotective treatment for ischemic injury and is indicated for use in cardiopulmonary bypass, cardiac arrest, and neonatal hypoxia...
  47. Cardioscopy New Platform for Less Invasive Surgery on the Beating Heart
    Tomislav Mihaljevic; Fiscal Year: 2013
    ..The primary cardiopulmonary bypass circuit secures hemodynamic stability by providing systemic and coronary perfusion...
  48. Cell Therapy for Septic Shock
    Deborah A Buffington; Fiscal Year: 2010
    ..SIRS, is a catastrophic sequela of a variety of clinical insults, including infection, pancreatitis, and cardiopulmonary bypass, and claims over forty thousand lives in the U.S. each year...
  49. Development of Percutaneous DLC for Total Cavo-pulmonary Assistance
    Dongfang Wang; Fiscal Year: 2011
    ..ultimate goal is to develop a CPA system that avoids the need for an open surgical procedure or the use of cardiopulmonary bypass (CPB)...
  50. Role of NCKX2 in the activation of toxic Zn2+ influx in ischemic neurons
    Lech Kiedrowski; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: About 32% of the very commonly performed cardiac surgeries involving cardiopulmonary bypass (CPB) cause ischemic events in the brain and carry a significant risk of post-operative cognitive deficits...
  51. Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass
    Eric M Graham; Fiscal Year: 2013
    ..b>Cardiopulmonary bypass (CPB) is critical to cardiac surgery, but the pathophysiologic processes engendered by CPB play an ..
  52. Shared Resource for Disease Model Surgical Critical Care and Data Mangement
    Hansell H Stedman; Fiscal Year: 2010
    ..machines with built-in critical care monitoring and data storage/retrieval/analysis function for use with cardiopulmonary bypass in one setting and MRI in the other setting...
  53. Baylor/Texas Children's Hospital Pediatric Heart Network
    LARA SEVANNE SHEKERDEMIAN; Fiscal Year: 2013
    ..DHCA. RELEVANCE: This large multicentered study is designed to determine the preferred method of cardiopulmonary bypass for neonatal aortic arch reconstruction...
  54. Neurocognitive Function and Cerebral Perfusion in Cardiac Surgery
    Daniel C Lee; Fiscal Year: 2011
    ..The brain is the organ most susceptible to damage from inadequate perfusion during cardiopulmonary bypass (CPB, i.e...
  55. Fifth International Conference on Pediatric Cardiac Devices
    Akif Undar; Fiscal Year: 2010
    ..include: pediatric cardiac assist devices;axial, centrifugal, rotary, and pulsatile pumps;ECMO;pediatric cardiopulmonary bypass, pediatric heart-lung machines and membrane oxygenators;pulsatile versus non-pulsatile perfusion;..
  56. Mannose binding lectin and outcomes following CABG
    GREGORY L contact STAHL; Fiscal Year: 2010
    ..therapy, percutaneous transluminal coronary angioplasty and coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB)...
  57. PATHOPHYSIOLOGY OF ISCHEMIA-REPERFUSION LUNG INJURY
    AUBREY TAYLOR; Fiscal Year: 1992
    ..Ischemia- reperfusion may play an etiological role in acute lung injury following lung transplantation, cardiopulmonary bypass, and removal of thrombotic obstruction of major pulmonary arteries, and may be a factor in re-expansion ..
  58. Operative Strategies To Reduce Cerebral Embolic Events During CABG
    Michael Halkos; Fiscal Year: 2013
    ..Manipulation of the aorta during CABG occurs during aortic cannulation, institution and maintenance of cardiopulmonary bypass, and during aortic clamping and unclamping with either a cross-clamp, partial-occluding clamp, or both...
  59. PumpKIN Preclinical Program
    JANET SIMONS; Fiscal Year: 2011
    ..use for up to 30 days in patients weighing 3-25 kg who 1) are not sufficiently stable to be weaned from cardiopulmonary bypass after surgery;2) have severe primary respiratory failure or secondary failure associated with cardiac ..
  60. PumpKIN Preclinical Program
    Bartley Griffith; Fiscal Year: 2013
    ..use for up to 30 days in patients weighing 3-25 kg who 1) are not sufficiently stable to be weaned from cardiopulmonary bypass after surgery;2) have severe primary respiratory failure or secondary failure associated with cardiac ..
  61. PumpKIN Preclinical Program
    JANET SIMONS; Fiscal Year: 2010
    ..use for up to 30 days in patients weighing 3-25 kg who 1) are not sufficiently stable to be weaned from cardiopulmonary bypass after surgery;2) have severe primary respiratory failure or secondary failure associated with cardiac ..
  62. PumpKIN Preclinical Program
    Bartley Griffith; Fiscal Year: 2012
    ..use for up to 30 days in patients weighing 3-25 kg who 1) are not sufficiently stable to be weaned from cardiopulmonary bypass after surgery;2) have severe primary respiratory failure or secondary failure associated with cardiac ..
  63. Mechanism of Vasopressin-Mediated Placental Vascular Resistance after Fetal Bypas
    Pirooz Eghtesady; Fiscal Year: 2010
    ..Certain interventions require in utero open-heart surgery, which in turn necessitates cardiopulmonary bypass support...
  64. RIGHT VENTRICULAR DYSFUNCTION AFTER PRESSURE OVERLOAD
    Clifford Greyson; Fiscal Year: 2006
    ..in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation...
  65. PREVENTION OF ORGAN INJURY DURING CARDIOPULMONARY BYPASS
    DUKE CAMERON; Fiscal Year: 1993
    ..examine the roles of complement and leukocytes in the pathogenesis of "post-perfusion syndome" (PPS) after cardiopulmonary bypass (CPB) and to determine if inhibition of complement activation and depletion of leukocytes by mechanical ..
  66. CLINICAL TRIAL OF HEMATOCRIT STRATEGY IN HEART SURGERY
    Jane Newburger; Fiscal Year: 2004
    The optimal degree of hemodilution during profoundly hypothermic cardiopulmonary bypass (CPB) remain controversial, and widely disparate hemodilution protocols have evolved at centers undertaking infant cardiac surgery...
  67. SURGICAL CORDIOPULMONARY BYPASS AND CEREBRAL RESISTANCE
    William Johnston; Fiscal Year: 1993
    ..Although embolization of gaseous and particulate matter has been observed during cardiopulmonary bypass, impaired cerebral perfusion during bypass contributes significantly to the severity of the deficit...
  68. APOLIPOPROTEIN E AND THE ISCHEMIC BRAIN
    David Warner; Fiscal Year: 2001
    ..Patients undergoing cardiopulmonary bypass surgical procedures, and those recovering form intracranial hemorrhagic stroke or head trauma have poorer ..
  69. Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
    Mias Pretorius; Fiscal Year: 2010
    Each year over a million patients worldwide undergo cardiac surgery requiring cardiopulmonary bypass (CPB)...
  70. Pediatric Thin-Film TiNi Catheter-Based Heart Valve
    Daniel Levi; Fiscal Year: 2005
    Heart valve replacement in pediatric patients continues to require an invasive surgical approach including cardiopulmonary bypass, a midline sternotomy, and significant rehabilitation...
  71. A minimally invasive cardiac assist device
    Walid Aboulhosn; Fiscal Year: 2004
    ..Existing devices for mechanical circulatory support require open chest surgery, cardiopulmonary bypass and cannulation of the heart and major vessels for device implantation, and are associated with high ..
  72. A novel nonthrombogenic vascular circuit
    Garry Southan; Fiscal Year: 2001
    ..surface for the prevention of post-operative platelet dysfunction and consumption induced by cardiopulmonary bypass surgery...