thyroidectomy

Summary

Summary: Surgical removal of the thyroid gland. (Dorland, 28th ed)

Top Publications

  1. pmc Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients: pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Ann Surg 245:604-10. 2007
  2. ncbi Thyroid surgery in the geriatric patient
    Christian Passler
    Division of General Surgery Endocrine Surgery, Department of Surgery, University Hospital, Vienna, Austria
    Arch Surg 137:1243-8. 2002
  3. ncbi The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a comparative study on 1000 nerves at risk
    Wai Fan Chan
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Surgery 140:866-72; discussion 872-3. 2006
  4. doi Robot-assisted endoscopic surgery for thyroid cancer: experience with the first 100 patients
    Sang Wook Kang
    Department of Surgery, Yonsei University College of Medicine, C P O Box 8044, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, South Korea
    Surg Endosc 23:2399-406. 2009
  5. doi Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy
    M Barczynski
    Department of Endocrine Surgery, Jagiellonian University College of Medicine, Krakow, Poland
    Br J Surg 96:240-6. 2009
  6. ncbi Papillary microcarcinoma of the thyroid-Prognostic significance of lymph node metastasis and multifocality
    Sin Ming Chow
    Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, People s Republic of China
    Cancer 98:31-40. 2003
  7. pmc Staging systems for papillary thyroid carcinoma: a review and comparison
    Brian Hung Hin Lang
    Division of Endocrine Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Ann Surg 245:366-78. 2007
  8. ncbi Early malignant progression of hereditary medullary thyroid cancer
    Andreas Machens
    Klinik fUr Allgemein, Viszeral, und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg, Halle, Saale, Germany
    N Engl J Med 349:1517-25. 2003
  9. doi Subclinical lymph node metastasis in papillary thyroid microcarcinoma: a study of 551 resections
    Yoon Kyoung So
    Department of Otorhinolaryngology Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Surgery 148:526-31. 2010
  10. ncbi Transoral access for endoscopic thyroid resection
    K Witzel
    Department of Surgery, Paracelsus Medical Private University, Muellner Hauptstrasse 48, A 5020, Salzburg, Austria
    Surg Endosc 22:1871-5. 2008

Research Grants

  1. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
  2. Thyroid hormone regulation of vasculature in adult myocardium
    Anthony Martin Gerdes; Fiscal Year: 2010
  3. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2013
  4. Assessing Indeterminate Thyroid Nodules With Electrical Impedance Measurements
    Mitchell E Tublin; Fiscal Year: 2012
  5. Molecular Classification of Suspicious Thyroid Tumors
    Martha Zeiger; Fiscal Year: 2009
  6. ONTOGENY AND HORMONAL CONTROL OF CARDIAC NADH SHUTTLES
    Thomas Scholz; Fiscal Year: 2001
  7. Extracellular matrix and protease markers of malignant thyroid neoplasm
    Electron Kebebew; Fiscal Year: 2007
  8. RADIATION INDUCED THYROID CANCER
    Heinz Ulrich Weier; Fiscal Year: 2002
  9. CONTROL MECHANISMS IN INTERMEDIARY METABOLISM
    EARL SHRAGO; Fiscal Year: 1990
  10. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003

Detail Information

Publications453 found, 100 shown here

  1. pmc Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients: pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Ann Surg 245:604-10. 2007
    To investigate the pattern of nodal metastasis, morbidity, recurrence rates of papillary thyroid carcinoma (PTC), and parathyroid hormone (PTH) responses following neck dissection (ND) plus total thyroidectomy (TT).
  2. ncbi Thyroid surgery in the geriatric patient
    Christian Passler
    Division of General Surgery Endocrine Surgery, Department of Surgery, University Hospital, Vienna, Austria
    Arch Surg 137:1243-8. 2002
    ..Although age itself is no contraindication for major surgical procedures, few patients 75 years and older undergo thyroid surgery...
  3. ncbi The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a comparative study on 1000 nerves at risk
    Wai Fan Chan
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Surgery 140:866-72; discussion 872-3. 2006
    The role of intraoperative neuromonitoring of recurrent laryngeal nerve (RLN) during thyroidectomy has not been well established...
  4. doi Robot-assisted endoscopic surgery for thyroid cancer: experience with the first 100 patients
    Sang Wook Kang
    Department of Surgery, Yonsei University College of Medicine, C P O Box 8044, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, South Korea
    Surg Endosc 23:2399-406. 2009
    ..This study aimed to introduce the authors' technique of robot-assisted endoscopic thyroid surgery and to demonstrate its applicability in the surgical management of thyroid cancer...
  5. doi Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy
    M Barczynski
    Department of Endocrine Surgery, Jagiellonian University College of Medicine, Krakow, Poland
    Br J Surg 96:240-6. 2009
    ..The aim of this study was to test the hypothesis that identification of the recurrent laryngeal nerve (RLN) during thyroid surgery reduces injury, and that intraoperative nerve monitoring may be of additional benefit...
  6. ncbi Papillary microcarcinoma of the thyroid-Prognostic significance of lymph node metastasis and multifocality
    Sin Ming Chow
    Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, People s Republic of China
    Cancer 98:31-40. 2003
    ..The rising incidence of PMC among papillary thyroid carcinoma (PTC) necessitates the identification of prognostic factors and the formulation of treatment protocols...
  7. pmc Staging systems for papillary thyroid carcinoma: a review and comparison
    Brian Hung Hin Lang
    Division of Endocrine Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Ann Surg 245:366-78. 2007
    ..To find out the most predictive staging system for papillary thyroid carcinoma (PTC) currently available in the literature...
  8. ncbi Early malignant progression of hereditary medullary thyroid cancer
    Andreas Machens
    Klinik fUr Allgemein, Viszeral, und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg, Halle, Saale, Germany
    N Engl J Med 349:1517-25. 2003
    ....
  9. doi Subclinical lymph node metastasis in papillary thyroid microcarcinoma: a study of 551 resections
    Yoon Kyoung So
    Department of Otorhinolaryngology Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Surgery 148:526-31. 2010
    ..We aimed to study clinicopathologic factors associated with subclinical central LNM to be considered for determination of prophylactic CLND...
  10. ncbi Transoral access for endoscopic thyroid resection
    K Witzel
    Department of Surgery, Paracelsus Medical Private University, Muellner Hauptstrasse 48, A 5020, Salzburg, Austria
    Surg Endosc 22:1871-5. 2008
    ..The authors tested the feasibility of the sublingual transoral access, which they believe is the most promising minimally invasive endoscopic access to the thyroid gland from outside the neck region...
  11. doi Robotic thyroid surgery using a gasless, transaxillary approach and the da Vinci S system: the operative outcomes of 338 consecutive patients
    Sang Wook Kang
    Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea
    Surgery 146:1048-55. 2009
    ..Herein the authors describe the technique used and its utility for the operative management of thyroid tumors...
  12. ncbi Prognostic factors in papillary and follicular thyroid carcinoma: their implications for cancer staging
    Brian Hung Hin Lang
    Division of Endocrine Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    Ann Surg Oncol 14:730-8. 2007
    ..However, this may not be an optimal approach to cancer staging...
  13. doi Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid: results of a study in 445 patients
    Giuseppe Mercante
    Department of Otolaryngology, Thyroid Disease Center Arcispedale Santa Maria Nuova of Reggio Emilia, Reggio Emilia, Italy
    Thyroid 19:707-16. 2009
    The management of thyroid papillary microcarcinoma (PMC) is controversial. Total thyroidectomy, thyroid lobectomy/isthmectomy, and even no treatment have been proposed...
  14. doi Total thyroidectomy for benign thyroid disease: is it really worthwhile?
    Marcin Barczynski
    Department of General Surgery, Jagiellonian University, Medical College, Krakow, Poland
    Ann Surg 254:724-29; discussion 729-30. 2011
    To compare the outcomes of bilateral subtotal (BST) versus total thyroidectomy (TT) for benign bilateral thyroid disease (BBTD).
  15. doi Routine central neck dissection in differentiated thyroid carcinoma: a systematic review and meta-analysis
    Cheng Xiang Shan
    Department of General Surgery, Chang Zheng Hospital Affiliated to Second Military Medical University, Shanghai, People s Republic of China
    Laryngoscope 122:797-804. 2012
    ..The role of central neck dissection (CND) remains controversial in differentiated thyroid cancer (DTC)...
  16. doi Anti-emetic effect of ondansetron and palonosetron in thyroidectomy: a prospective, randomized, double-blind study
    Y E Moon
    Department of Anaesthesiology and Pain Medicine, Seoul St Mary s Hospital, Catholic University College of Medicine, Seoul, Republic of Korea
    Br J Anaesth 108:417-22. 2012
    ..This study compared the effects of i.v. ondansetron and palonosetron administered at the end of surgery in preventing postoperative nausea and vomiting (PONV) in high-risk patients receiving i.v. PCA after thyroidectomy.
  17. doi Diagnosis of recurrent laryngeal nerve palsy after thyroidectomy: a systematic review
    J P Jeannon
    Department of Otolaryngology Head and Neck Surgery, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK
    Int J Clin Pract 63:624-9. 2009
    ..The aim of this study was to determine the reported incidence of temporary and permanent palsy after thyroid surgery using different vocal assessment methods...
  18. doi Comparative study of endoscopic thyroidectomy versus conventional open thyroidectomy in papillary thyroid microcarcinoma (PTMC) patients
    Jong Ju Jeong
    Department of Surgery, Yonsei University College of Medicine, Seodaemun gu, Seoul, South Korea
    J Surg Oncol 100:477-80. 2009
    ..The aim of this study was to evaluate and compare the early surgical outcomes of endoscopic and conventional open thyroidectomies in patients with papillary thyroid microcarcinoma (PTMC)...
  19. doi Comparison of endoscopic and robotic thyroidectomy
    J Lee
    Department of Surgery, Ajou University School of Medicine, Suwon, Korea
    Ann Surg Oncol 18:1439-46. 2011
    Endoscopic thyroidectomy is a technically challenging procedure. Robot-assisted thyroidectomy has been recently introduced and offers improved visualization and dexterity...
  20. doi Prognostic factors of disease-free survival after thyroidectomy in 170 young patients with a RET germline mutation: a multicenter study of the Groupe Francais d'Etude des Tumeurs Endocrines
    V Rohmer
    Centre Hospitalier Universitaire Angers, Endocrinologie, Faculte de Medecine, Université Angers, Angers 49933, France
    J Clin Endocrinol Metab 96:E509-18. 2011
    ..In hereditary medullary thyroid carcinoma (HMTC), prophylactic surgery is the only curative option, which should be properly defined both in time and extent...
  21. doi Is robotic surgery superior to endoscopic and open surgeries in thyroid cancer?
    Wan Wook Kim
    Department of Surgery, Kyungpook National University, Daegu, Korea
    World J Surg 35:779-84. 2011
    ..The aim of the present study was to determine whether robotic surgery is superior to endoscopic and open surgery through comparing technical aspects and surgical outcomes...
  22. pmc Impact of routine unilateral central neck dissection on preablative and postablative stimulated thyroglobulin levels after total thyroidectomy in papillary thyroid carcinoma
    Brian Hung Hin Lang
    Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong SAR, China
    Ann Surg Oncol 19:60-7. 2012
    ..Because postsurgical stimulated thyroglobulin (sTg) level is a good surrogate for recurrence, the study aimed to evaluate the impact of prophylactic CND on preablative and postablative sTg levels after total thyroidectomy.
  23. ncbi Nodal yield, morbidity, and recurrence after central neck dissection for papillary thyroid carcinoma
    Jose A Pereira
    Department of Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain
    Surgery 138:1095-100, discussion 1100-1. 2005
    The role of central neck dissection (CND) in differentiated thyroid cancer remains controversial. This study aims at elucidating the potential benefits and drawbacks of CND associated to total thyroidectomy in papillary cancer.
  24. ncbi Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe City, 650 0011, Japan
    World J Surg 30:91-9. 2006
    ....
  25. ncbi Routine ipsilateral level VI lymphadenectomy reduces postoperative thyroglobulin levels in papillary thyroid cancer
    Mark Sywak
    Endocrine Surgical Unit, University of Sydney, Sydney, Australia
    Surgery 140:1000-5; discussion 1005-7. 2006
    ..The aim of this study is to determine whether routine ipsilateral level VI lymphadenectomy (LNDVI) has advantages over total thyroidectomy (TT) alone.
  26. doi Clinical practice. Graves' disease
    Gregory A Brent
    Veterans Affairs Greater Los Angeles Healthcare System, and the Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    N Engl J Med 358:2594-605. 2008
  27. ncbi Assessment of the morbidity and complications of total thyroidectomy
    Neil Bhattacharyya
    Division of Otolaryngology, Brigham and Women s Hospital, Harvard Medical School, 333 Longwood Ave, Boston, MA 02115, USA
    Arch Otolaryngol Head Neck Surg 128:389-92. 2002
    To determine the incidence and predictive factors for complications after total thyroidectomy.
  28. ncbi Thyroid carcinoma
    Steven I Sherman
    Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Texas, Houston 77030, USA
    Lancet 361:501-11. 2003
    ....
  29. ncbi Endoscopic thyroidectomy for thyroid malignancies: comparison with conventional open thyroidectomy
    Yoo Seung Chung
    Department of Surgery, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    World J Surg 31:2302-6; discussion 2307-8. 2007
    ..We developed the bilateral axillo-breast (BAB) approach for total thyroidectomy. The aims of this study were to evaluate the completeness of this approach for total thyroidectomy and to ..
  30. doi Central neck lymph node dissection for papillary thyroid cancer: the reliability of surgeon judgment in predicting which patients will benefit
    Wen T Shen
    Department of Surgery, University of California, San Francisco Mt Zion Medical Center, San Francisco, CA 94115, USA
    Surgery 148:398-403. 2010
    ..We perform CLND for PTC only in patients with enlarged nodes as determined by preoperative ultrasound and intraoperative inspection and palpation...
  31. ncbi Skip metastases in thyroid cancer leaping the central lymph node compartment
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Arch Surg 139:43-5. 2004
    ..Discontinuous nodal metastasis, or skip metastasis, in thyroid cancer may display clinicopathologic features different from those seen in continuous nodal metastasis and thus may have a different prognosis...
  32. ncbi Complications of thyroid surgery: analysis of a multicentric study on 14,934 patients operated on in Italy over 5 years
    Lodovico Rosato
    Department of Surgery, Endocrine Surgical Unit, Ivrea Hospital, Piazza della Credenza, 2 10015 Ivrea, Italy
    World J Surg 28:271-6. 2004
    ..Among them, 3130 (20.9%) underwent total lobectomy (TL), 9599 (64.3%) total thyroidectomy (TT), 1448 (9.7%) subtotal thyroidectomy with a monolateral remnant (MRST), and 757 (5...
  33. ncbi The optimal treatment for pediatric Graves' disease is surgery
    James A Lee
    Department of Surgery, University California, San Francisco, Comprehensive Cancer Center at Mount Zion, Medical Center, 1600 Divisadero Street, Hellman Building, Room C347, San Francisco, California 94143 1764, USA
    J Clin Endocrinol Metab 92:801-3. 2007
  34. doi Sporadic hypercalcitoninemia: clinical and therapeutic consequences
    C Scheuba
    Department of Surgery, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Endocr Relat Cancer 16:243-53. 2009
    ..None of the patients was member of a known medullary thyroid carcinoma family. Thyroidectomy and bilateral central and lateral neck dissections were performed...
  35. doi Standardization of intraoperative neuromonitoring of recurrent laryngeal nerve in thyroid operation
    Feng Yu Chiang
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Kaohsiung Medical University, No 100, Tzyou First Road, Kaohsiung City, 807, Taiwan
    World J Surg 34:223-9. 2010
    ..Therefore, standardization of IONM procedures is necessary...
  36. doi Five-year follow-up of a randomized clinical trial of total thyroidectomy versus Dunhill operation versus bilateral subtotal thyroidectomy for multinodular nontoxic goiter
    Marcin Barczynski
    Department of Endocrine Surgery, 3rd Chair of General Surgery, Jagiellonian University College of Medicine, 37 Pradnicka Street, 31 202, Krakow, Poland
    World J Surg 34:1203-13. 2010
    ..The aim of the present study was to evaluate results of various thyroid resection modes, with special emphasis put on the recurrence rate and morbidity rate, in a 5-year follow-up...
  37. doi Minimally invasive video-assisted thyroidectomy: experience of 300 cases
    Youben Fan
    Department of Surgery, Sixth People s Hospital, Shanghai Jiaotong University, Shanghai, 200233, China
    Surg Endosc 24:2393-400. 2010
    We report on patients selected for minimally invasive video-assisted thyroidectomy (MIVAT) over a 3-year period and evaluate the feasibility and effects of this procedure.
  38. ncbi [Differentiated microcarcinoma of the thyroid gland]
    F Sorrentino
    A O U P Palermo, U O C di Chirurgia Generale, dell Uremico e dei Trapianti d Organo
    G Chir 31:277-8. 2010
    ..The aim of our study is to assess the frequency of microcarcinoma, the association of benign thyroid disease himself and the controversial surgery...
  39. pmc Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer
    Matthew A Nehs
    Thyroid Cancer Research Laboratory, Division of Endocrine Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Surgery 148:1154-62; discussion 1162. 2010
    ..We hypothesized that PLX4720 (an inhibitor of B-Raf(V600E)) and thyroidectomy would extend survival and would decrease tumor burden in a mouse model.
  40. doi The clinicopathologic differences in papillary thyroid carcinoma with or without co-existing chronic lymphocytic thyroiditis
    Yeo Hoon Yoon
    Department of Otolaryngology, Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University School of Medicine, 640 Daesa dong, Chung gu, Daejeon, 301 040, South Korea
    Eur Arch Otorhinolaryngol 269:1013-7. 2012
    ..We reviewed the medical records of 195 consecutive PTC patients who underwent total thyroidectomy and bilateral central lymph node dissection from April 2008 to March 2010...
  41. doi Intraoperative neuromonitoring does not reduce the incidence of recurrent laryngeal nerve palsy in thyroid reoperations: results of a retrospective comparative analysis
    Piero F Alesina
    Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Kliniken Essen Mitte, Akademisches Lehrkrankenhaus der Universität Duisburg Essen, Henricistrasse 92, 45136 Essen, Germany
    World J Surg 36:1348-53. 2012
    ..The present study is a retrospective analysis of the experience with completion thyroidectomy with and without neuromonitoring in a referral center.
  42. doi Total thyroidectomy, without prophylactic central lymph node dissection, in the treatment of differentiated thyroid cancer. Clinical retrospective study on 221 cases
    Giovanni Conzo
    Department of Anaesthesiologic, Surgical and Emergency Science, VII Division of General and Endocrine Surgery, Second University of Naples, Via Pansini 5, Build 17, 80131, Naples, Italy
    Endocrine 44:419-25. 2013
    Total thyroidectomy (TT) is the standard of care for differentiated thyroid cancer (DTC), but still there is no consensus about the role of routine use of prophylactic central lymph node dissection...
  43. ncbi Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre
    Serdar Ozbas
    Department of General Surgery, Adnan Menderes University, Aydin, Turkey
    Endocr J 52:199-205. 2005
    Purpose of the study is to compare complication rates of bilateral subtotal (BST), near total (NTT) and total thyroidectomy (TT) in a cohort of patients undergoing surgery for benign multinodular goitre (MNG)...
  44. ncbi Hashimoto thyroiditis coexistent with papillary thyroid carcinoma
    Calogero Cipolla
    University of Palermo, Department of Oncology, Division of General and Oncological Surgery Policlinico P Giaccone Palermo, Italy
    Am Surg 71:874-8. 2005
    ..of 89 subjects operated on for normofunctioning goiter, and a second group of 47 patients undergoing total thyroidectomy for HT. Association with HT was found in 19 of the 71 PTC subjects (26.7%) and in 8 goiter patients (8...
  45. ncbi Serum thyroglobulin concentrations predict disease-free remission and death in differentiated thyroid carcinoma
    Karen A Heemstra
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Endocrinol (Oxf) 66:58-64. 2007
    ..The objective was to investigate the prognostic values of serum Tg for disease-free remission and death, measured at fixed time-points after initial therapy using receiver operator characteristic (ROC) curve analyses...
  46. pmc Gasless endoscopic thyroidectomy via an anterior chest wall approach using a flap-lifting system
    Young Up Cho
    Department of Surgery, Inha University Hospital, Inha University College of Medicine, 7 206 3 ga, Sinheung Dong, Jung Gu, Incheon 400 711, Korea
    Yonsei Med J 48:480-7. 2007
    Endoscopic thyroidectomy (ET) requires a proper working space for adequate visualization of anatomical structures and proper instrument manipulation...
  47. ncbi Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis
    Elliot Sampson
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
    Cancer 110:1451-6. 2007
    ..Differentiated thyroid cancer has a good prognosis and only rarely presents with distant metastasis at diagnosis. The clinical outcome of this presentation was assessed with respect to survival and factors that may determine prognosis...
  48. pmc Thyroid surgery in octogenarians is associated with higher complication rates
    Michal Mekel
    Department of Surgery and Endocrine Surgery Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Surgery 146:913-21. 2009
    ..The aim of this study was to determine whether thyroid surgery in patients > or =80 is associated with higher complication rates...
  49. doi Features of papillary thyroid carcinoma in patients older than 75 years
    Antonio Toniato
    Surgical Pathology, Department of Medical and Surgical Sciences, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Updates Surg 63:115-8. 2011
    ..0001). Although papillary thyroid cancer is widely considered a lymph-tropic tumor, it seems to have a stronger attitude to distant metastases in elderly patients with a worse prognosis due to a more advanced stage...
  50. doi Management of the solitary thyroid nodule
    Meei J Yeung
    The Alfred Hospital, Monash University Endocrine Surgery Unit, Melbourne, Australia
    Oncologist 13:105-12. 2008
    ..Surgery followed by radioactive iodine ablation is the mainstay of treatment for differentiated thyroid cancers, and the majority of patients can expect high cure rates...
  51. doi Excellence in robotic thyroid surgery: a comparative study of robot-assisted versus conventional endoscopic thyroidectomy in papillary thyroid microcarcinoma patients
    Sohee Lee
    Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea
    Ann Surg 253:1060-6. 2011
    To confirm the merits of robotic thyroid surgery by comparing the surgical outcomes of robotic-assisted and conventional endoscopic thyroidectomy in papillary thyroid microcarcinoma (PTMC) patients.
  52. doi Thyroglobulin measurement before rhTSH-aided 131I ablation in detecting metastases from differentiated thyroid carcinoma
    Luca Giovanella
    Department of Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, CH 6500 Bellinzona, Switzerland
    Clin Endocrinol (Oxf) 69:659-63. 2008
    b>Thyroidectomy followed by administration of large activities of 131-iodine ((131)I) is the treatment of choice for differentiated thyroid carcinoma (DTC)...
  53. doi A population-based study of outcomes from thyroidectomy in aging Americans: at what cost?
    Julie Ann Sosa
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Coll Surg 206:1097-105. 2008
    We wanted to evaluate clinical and economic outcomes after thyroidectomy in patients 65 years of age and older, with special analyses of those aged 80 years and older, in the US.
  54. doi Therapeutic strategy for differentiated thyroid carcinoma in Japan based on a newly established guideline managed by Japanese Society of Thyroid Surgeons and Japanese Association of Endocrine Surgeons
    Hiroshi Takami
    Department of Surgery, Teikyo University School of Medicine, Tokyo, 173 8605, Japan
    World J Surg 35:111-21. 2011
    ..Total thyroidectomy followed by radioactive iodine (RAI) ablation has been a standard therapy in Western countries, while limited ..
  55. pmc Anaplastic thyroid carcinoma: three protocols combining doxorubicin, hyperfractionated radiotherapy and surgery
    J Tennvall
    Department of Oncology, Lund University Hospital, SE 221 85 Lund, Sweden
    Br J Cancer 86:1848-53. 2002
    ..017). In the 40 patients undergoing additional surgery, no signs of local recurrence were seen in 5 out of 9 patients, 11 out of 14 patients and 17 out of 17 patients, respectively (P=0.005)...
  56. ncbi The importance of central compartment elective lymph node excision in the staging and treatment of papillary thyroid cancer
    Maisie Shindo
    Division of Otolaryngology Head and Neck Surgery, School of Medicine, State University of New York at Stony Brook, USA
    Arch Otolaryngol Head Neck Surg 132:650-4. 2006
    ..To determine the incidence of nodal involvement and assess the role of elective lymph node (LN) exploration and/or dissection in staging of tumors and treatment of patients with papillary thyroid cancer...
  57. ncbi Intraoperative parathyroid hormone assay for management of patients undergoing total thyroidectomy
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Korea
    Head Neck 28:990-7. 2006
    Rapid parathyroid hormone (PTH) assay has been applied to predict hypocalcemia after thyroidectomy compared with conventional close monitoring of serum calcium levels...
  58. doi Harmonic scalpel in multinodular goiter surgery: impact on surgery and cost analysis
    Frederic Sebag
    Department of General and Endocrine Surgery, Hopital de la Timone, Marseille, France
    J Laparoendosc Adv Surg Tech A 19:171-4. 2009
    ..The aim of this study was to evaluate the potential advantages and the general operative cost of the Harmonic Scalpel (HS) in surgery for multinodular goiter (MNG)...
  59. doi Preoperative ultrasound-guided tattooing localization of recurrences after thyroidectomy: safety and effectiveness
    Tae Wook Kang
    Departments of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam Gu, Seoul, Republic of Korea
    Ann Surg Oncol 16:1655-9. 2009
    The incidence of nonpalpable recurrence detected on follow-up ultrasound (US) after thyroidectomy has increased. However, surgical approach for nonpalpable lesions can be difficult...
  60. doi Should all papillary thyroid microcarcinomas be aggressively treated? An analysis of 18,445 cases
    Xiao Min Yu
    Department of Surgery, University of Wisconsin Madison, WI 53792, USA
    Ann Surg 254:653-60. 2011
    ..The purpose of this study was to identify the risk factors that predict papillary thyroid microcarcinoma (PTMC)-related death in a large patient population to determine which patients need aggressive treatment...
  61. ncbi Cerebral blood flow abnormalities induced by transient hypothyroidism after thyroidectomy--analysis by tc-99m-HMPAO and SPM96
    Shigeki Nagamachi
    Department of Radiology, Miyazaki Medical College, Kihara, Japan
    Ann Nucl Med 18:469-77. 2004
    ..study is an investigation of alterations in regional cerebral blood flow (rCBF) distribution in patients with transient hypothyroidism after thyroidectomy. In addition, the effects of thyroxine treatment on rCBF changes were studied.
  62. ncbi Inadvertent parathyroid excision during thyroid surgery
    T E Rix
    Department of General Surgery, William Harvey Hospital, Ashford, Kent, UK
    Surgeon 4:339-42. 2006
    b>Thyroidectomy is a commonly performed operation for the treatment of thyroid disease...
  63. doi The genetic basis of hereditary medullary thyroid cancer: clinical implications for the surgeon, with a particular emphasis on the role of prophylactic thyroidectomy
    George H Sakorafas
    From the 4th Department of Surgery, Athens University Medical School, Attikon University Hospital, Arkadias 19 21, 115 26 Athens, Greece
    Endocr Relat Cancer 15:871-84. 2008
    ..Hereditary MTC is a model of genetically determined cancer in which both diagnostic and therapeutic strategies rely on the identification of specific mutations...
  64. doi Endoscopic hemithyroidectomy with prophylactic ipsilateral central neck dissection via an unilateral axillo-breast approach without gas insufflation for unilateral micropapillary thyroid carcinoma: preliminary report
    Yoon Woo Koh
    Department of Otolaryngology Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea
    Surg Endosc 24:188-97. 2010
    ..However, few specific data exist on endoscopic thyroidectomy with central neck dissection (CND) for micropapillary thyroid carcinoma...
  65. doi Intraoperative monitoring of the recurrent laryngeal nerve in thyroid surgery
    H Dralle
    Department of General, Visceral and Vascular Surgery, Martin Luther University of Halle, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    World J Surg 32:1358-66. 2008
    ..Nevertheless, a systematic evidence-based assessment of this novel health technology has not been performed...
  66. doi Thyroidectomy for Hashimoto's thyroiditis: complications and associated cancers
    Ming Lang Shih
    Division of General Surgery, Department of Surgery, National Defense Medical Center, Taipei, Taiwan, R O C
    Thyroid 18:729-34. 2008
    Hashimoto's thyroiditis is usually treated medically; however, thyroidectomy is sometimes indicated. Thyroiditis can make thyroid dissection more difficult and possibly increase the risk of surgical complications...
  67. ncbi External laryngeal nerve in thyroid surgery: recognition and surgical implications
    E N Aina
    Department of Surgery, Kuala Lumpur Hospital, Malaysia
    ANZ J Surg 71:212-4. 2001
    ..Recognition of the potential avascular space aids the exposure and preservation of ELN. As such every attempt should be made to ensure safe dissection in order to reduce morbidity related to thyroid surgery...
  68. ncbi Total thyroidectomy is now the preferred option for the surgical management of Graves' disease
    Michael S Barakate
    University of Sydney Endocrine Surgical Unit, Department of Surgery, Australia
    ANZ J Surg 72:321-4. 2002
    Subtotal thyroidectomy has been advocated as the standard treatment for Graves' disease because of the possibility of avoiding thyroxine therapy as well as the assumed lower risk of complications compared to total thyroidectomy...
  69. ncbi Minimally invasive endoscopic thyroidectomy by a cervical approach
    W B Inabnet
    Division of Laparoscopic Surgery, Department of Surgery, Mount Sinai Medical Center, 5 East 98th Street, Box 1259, New York, NY 10029, USA
    Surg Endosc 17:1808-11. 2003
    The technique of thyroidectomy mandates adequate visualization of the operative field to identify pertinent anatomical structures...
  70. ncbi Total thyroidectomy for multinodular goiter in the elderly
    Brian Hung Hin Lang
    Division of Endocrine Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    Am J Surg 190:418-23. 2005
    Total thyroidectomy for multinodular goiter (MNG) is increasingly being performed for the elderly population and yet their perioperative and long-term outcomes remain unclear.
  71. ncbi Randomized controlled trial of harmonic scalpel use during thyroidectomy
    Paolo Miccoli
    Department of Surgery, University of Pisa, Pisa, Italy
    Arch Otolaryngol Head Neck Surg 132:1069-73. 2006
    To compare operative factors, postoperative outcomes, and surgical complications of thyroidectomy when using the harmonic scalpel (HS) vs conventional hemostasis (CH).
  72. ncbi Endoscopic thyroidectomy using a new bilateral axillo-breast approach
    Jun Ho Choe
    Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea
    World J Surg 31:601-6. 2007
    ..We modified the axillo-bilateral breast approach (ABBA) and developed the bilateral axillo-breast approach (BABA) to obtain optimal visualization for total thyroidectomy.
  73. ncbi Gasless endoscopic thyroidectomy using trans-axillary approach; surgical outcome of 581 patients
    Sang Wook Kang
    Department of Surgery, Yonsei University College of Medicine, Seodaemun gu, Seoul, South Korea
    Endocr J 56:361-9. 2009
    ..We have developed a novel method of gasless endoscopic thyroidectomy via an axillary approach...
  74. pmc A comparison of surgical outcomes between endoscopic and robotically assisted thyroidectomy: the authors' initial experience
    Brian Hung Hin Lang
    Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    Surg Endosc 25:1617-23. 2011
    The gasless, transaxillary endoscopic thyroidectomy (GTET) offers a distinct advantage over the conventional open operation by leaving no visible neck scar, and in an attempt to improve its ergonomics and surgical outcomes, the ..
  75. ncbi Advantages of recurrent laryngeal nerve identification in thyroidectomy and parathyroidectomy and the importance of preoperative and postoperative laryngoscopic examination in more than 1000 nerves at risk
    Martin Steurer
    Department of Otorhinolaryngology Head and Neck Surgery, Vienna Medical School, General Hospital Vienna, Waeringer Guertel 18 20, A 1090 Vienna, Austria
    Laryngoscope 112:124-33. 2002
    ..Besides, misdiagnosis is not uncommon. Therefore, preoperative and postoperative laryngoscopic examination was given attention...
  76. ncbi Ultrasonographically and anatomopathologically detectable node metastases in the lateral compartment as indicators of worse relapse-free survival in patients with papillary thyroid carcinoma
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, Chuo Ku, Kobe, Japan
    World J Surg 29:917-20. 2005
    ..AP)-detectable metastasis] in 560 patients with papillary carcinoma >1 cm in diameter, who underwent thyroidectomy with modified radical neck dissection at our hospital...
  77. ncbi Hyperthyroidism
    David S Cooper
    Division of Endocrinology, Sinai Hospital of Baltimore, Johns Hopkins University School of Medicine, MD 21215 5271, USA
    Lancet 362:459-68. 2003
    ..The more unusual causes of hyperthyroidism, including struma ovarii, thyrotropin-secreting tumours, choriocarcinoma, and amiodarone-induced thyrotoxicosis are, more often than not, a challenge to diagnose and treat...
  78. ncbi Intraoperative electromyographic monitoring of the recurrent laryngeal nerve in reoperative thyroid and parathyroid surgery
    Donald E Yarbrough
    Department of Surgery, College of Medicine, Mayo Clinic, Mayo Building W6, 200 First Street SW, Rochester, MN 55905, USA
    Surgery 136:1107-15. 2004
    ..The use of continuous, intraoperative electromyographic monitoring of the RLN has been suggested to improve the safety of cervical explorations...
  79. doi Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone
    Edward J Chisholm
    Department of ENT and Thyroid Surgery, St Mary s Hospital, Imperial College Hospitals NHS Trust, London, UK
    Laryngoscope 119:1135-9. 2009
    Meta-analysis to assess the increased morbidity of performing a central neck dissection with thyroidectomy to thyroidectomy alone.
  80. ncbi Implications of prognostic factors and risk groups in the management of differentiated thyroid cancer
    Ashok R Shaha
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Laryngoscope 114:393-402. 2004
    ..The study describes the author's treatment approach related to the extent of thyroidectomy and adjuvant therapy based on various risk groups and the long-term survival.
  81. ncbi Long-term outcome in 46 gene carriers of hereditary medullary thyroid carcinoma after prophylactic thyroidectomy: impact of individual RET genotype
    K Frank-Raue
    Endokrinologische Gemeinschaftspraxis, 69120 Heidelberg, Germany
    Eur J Endocrinol 155:229-36. 2006
    ..proto-oncogene mutation, curative treatment of medullary thyroid carcinoma (MTC) is possible by prophylactic thyroidectomy. Recommendations on the timing and extent of thyroidectomy are based upon a model that utilises genotype-..
  82. ncbi Aggressiveness and outcome of papillary thyroid carcinoma (PTC) versus microcarcinoma (PMC): a mono-institutional experience
    C Cappelli
    Department of Medical and Surgical Sciences, Internal Medicine and Endocrinology Unit, University of Brescia, Brescia, Italy
    J Surg Oncol 95:555-60. 2007
    ....
  83. doi Clinical and economic outcomes of thyroid and parathyroid surgery in children
    Julie Ann Sosa
    Department of Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, Wisconsin 53226, USA
    J Clin Endocrinol Metab 93:3058-65. 2008
    Clinical and economic outcomes after thyroidectomy/parathyroidectomy in adults have demonstrated disparities based on patient age and race/ethnicity; there is a paucity of literature on pediatric endocrine outcomes.
  84. doi Central cervical nodal metastasis from papillary thyroid microcarcinoma: pattern and factors predictive of nodal metastasis
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Pungnap dong, Songpa Gu, Seoul, 138 736, South Korea
    Ann Surg Oncol 15:2482-6. 2008
    ..We evaluated the pattern and factors predictive of central cervical metastasis from PTMC...
  85. doi Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissection
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Cancer 115:251-8. 2009
    ..supplementation may prevent hypocalcemic crisis, but its efficacy has not been studied in patients undergoing thyroidectomy plus central neck dissection (CND)...
  86. ncbi Outcomes of patients with differentiated thyroid carcinoma following initial therapy
    Jacqueline Jonklaas
    Georgetown University Medical Center, Washington, DC 20007, USA
    Thyroid 16:1229-42. 2006
    ..Treatments employed included near-total thyroidectomy, administration of radioactive iodine, and thyroid hormone suppression therapy...
  87. ncbi Impact of RET proto-oncogene analysis on the clinical management of multiple endocrine neoplasia type 2
    Sergio Pereira de Almeida Toledo
    Genetic Endocrinology Unit LIM 25, Internal Medicine Department, Sao Paulo University Medical School, Sao Paulo SP, Brazil
    Clinics (Sao Paulo) 61:59-70. 2006
    ..Further, prophylactic total thyroidectomy is indicated in all cases harboring activating gametic RET mutations...
  88. ncbi Central lymph node dissection in differentiated thyroid cancer
    Matthew L White
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    World J Surg 31:895-904. 2007
    ..A comprehensive review of this body of literature using evidence-based methodology is pending...
  89. ncbi The advantage of total thyroidectomy to avoid reoperation for incidental thyroid cancer in multinodular goiter
    Yasemin Giles
    Departments of Surgery and Endocrinology, Istanbul Medical Faculty, Istanbul, Turkey
    Arch Surg 139:179-82. 2004
    To investigate the impact of total thyroidectomy on the rate of completion thyroidectomy for incidentally found thyroid cancer in euthyroid multinodular goiter.
  90. ncbi Current strategies for surgical management and adjuvant treatment of childhood papillary thyroid carcinoma
    Geoffrey B Thompson
    Department of Surgery, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    World J Surg 28:1187-98. 2004
    ..Optimal initial treatment of childhood papillary thyroid carcinoma should include total or near-total thyroidectomy and central compartment node clearance...
  91. ncbi Serum levels of the interferon-gamma-inducible alpha chemokine CXCL10 in patients with active Graves' disease, and modulation by methimazole therapy and thyroidectomy
    A Antonelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Br J Surg 93:1226-31. 2006
    ..The aim of this study was to measure serum levels of CXCL10 in relation to thyroid function and treatment...
  92. ncbi Preoperative undetectable serum thyroglobulin in differentiated thyroid carcinoma: incidence, causes and management strategy
    Luca Giovanella
    Nuclear Medicine and Thyroid Unit, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    Clin Endocrinol (Oxf) 67:547-51. 2007
    ..Clearly, a negative Tg measurement may falsely reassure both the patient and the clinician in these cases...
  93. doi Risk factors for transient vocal cord palsy after thyroidectomy
    J J Sancho
    Endocrine Surgery Unit, Department of Surgery, Hospital del Mar, Barcelona, Spain
    Br J Surg 95:961-7. 2008
    Transient recurrent laryngeal nerve palsy affects to 5-10 per cent of patients after extracapsular thyroidectomy. This prospective study assessed the impact of surgical injury and extralaryngeal branching of the inferior laryngeal nerve (..
  94. doi Complications in primary and completed thyroidectomy
    Michael Vaiman
    Department of Otorhinolaryngology, Head and Neck Surgery, Assaf Harofeh Medical Center Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
    Surg Today 40:114-8. 2010
    To compare the rates of postsurgical complications following a primary and completed thyroidectomy for multinodular goiter (MNG).
  95. doi Do the recent American Thyroid Association (ATA) Guidelines accurately guide the timing of prophylactic thyroidectomy in MEN2A?
    Elizabeth G Grubbs
    Department of Surgical Oncology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Surgery 148:1302-9; discussion 1309-10. 2010
    In 2009, the American Thyroid Association (ATA) published consensus guidelines for timing of prophylactic thyroidectomy (PrThy) for treatment of hereditary medullary thyroid cancer (MTC)...
  96. doi Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy
    Eva K Wirth
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 165:555-61. 2011
    ..MCT8 contributes to hormone release from the thyroid gland...
  97. doi The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center
    Rossella Elisei
    Department of Endocrinology and Metabolism, World Health Organization Collaborating Center for the Diagnosis and Treatment of Thyroid Cancer and Other Thyroid Diseases, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 97:426-35. 2012
    ..In hereditary cases, a germline RET mutation is found in 98% of families. Because MTC is cured only if intrathyroidal, prophylactic thyroidectomy is recommended in the gene carrier (GC).
  98. ncbi Thyroidectomy of house sparrows (Passer domesticus) prevents photo-induced testicular growth but not the increased hypothalamic gonadotrophin-releasing hormone
    A Dawson
    Institute of Terrestrial Ecology, Huntingdon, Cambridgeshire, United Kingdom
    Gen Comp Endocrinol 110:196-200. 1998
    b>Thyroidectomy of starlings (Sturnus vulgaris) prevents the decrease in hypothalamic gonadotrophin-releasing hormone (GnRH) which normally occurs at the onset of photorefractoriness...
  99. ncbi Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers
    Gabriela E Sanso
    Centro de Investgaciones Endocrinológicas, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Cancer 94:323-30. 2002
    ..Its prognosis is dependent on the appearance and spread of medullary thyroid carcinoma (MTC). Relatives at risk can be identified before clinical or biochemical signs of the disease become evident...
  100. ncbi Effect of hypothyreosis on the content of ceramides in rat tissues
    M Gorska
    Department of Gerontology, Medical University of Białystok, Białystok, Poland
    J Physiol Pharmacol 54:89-97. 2003
    ..The control rats were sham operated. 30 days after thyroidectomy or sham operation the rats were anaesthetized and samples of the liver, white and red vastus lateralis and ..
  101. ncbi Efficacy of anti-adhesive barriers in secondary thyroidectomy: an experimental study
    Ozgur Yigit
    Department of Otorhinolaryngology, Head and Neck Surgery, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
    Laryngoscope 114:1668-73. 2004
    ..compare the effectiveness of two anti-adhesive barriers (Seprafilm and Interceed) for reducing adhesions after thyroidectomy in a rat model...

Research Grants48

  1. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..ago, we and our collaborators in Germany began to archive thyroid tumor tissues from patients who underwent thyroidectomy near the site of the power plant, among them 214 specimens from children...
  2. Thyroid hormone regulation of vasculature in adult myocardium
    Anthony Martin Gerdes; Fiscal Year: 2010
    ..After demonstrating that hypothyroidism induced by either thyroidectomy or propylthioruacil (PTU) leads to a dramatic loss of myocardial arterioles within 6 weeks, we have shown a ..
  3. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2013
    ..therapy for patients with MTC, almost all patients will have persistent or recurrent disease after total thyroidectomy and central lymph node dissection...
  4. Assessing Indeterminate Thyroid Nodules With Electrical Impedance Measurements
    Mitchell E Tublin; Fiscal Year: 2012
    ..Many of these patients will require at least partial thyroidectomy purely for the purpose of obtaining a definitive diagnosis...
  5. Molecular Classification of Suspicious Thyroid Tumors
    Martha Zeiger; Fiscal Year: 2009
    ..may undergo unnecessary surgery and some with malignant lesions may require a second operation for completion thyroidectomy once a diagnosis of malignancy is rendered on permanent histological section...
  6. ONTOGENY AND HORMONAL CONTROL OF CARDIAC NADH SHUTTLES
    Thomas Scholz; Fiscal Year: 2001
    ..fetal sheet will receive saline infusion (control twin) or infusion of either insulin or triiodothyronine or thyroidectomy (test twin). Shuttle capacities will be measured using isolated cardiac mitochondria from these animals...
  7. Extracellular matrix and protease markers of malignant thyroid neoplasm
    Electron Kebebew; Fiscal Year: 2007
    ..enough to determine which patients with suspicious or indeterminate FNA cytologic findings should undergo thyroidectomy. Consequently, all of these patients require a diagnostic thyroidectomy in order to accurately diagnose their ..
  8. RADIATION INDUCED THYROID CANCER
    Heinz Ulrich Weier; Fiscal Year: 2002
    ..Eight years ago, we began to archive thyroid tumor tissues from patients who underwent thyroidectomy near the site of the power plant, among them 214 specimens from children...
  9. CONTROL MECHANISMS IN INTERMEDIARY METABOLISM
    EARL SHRAGO; Fiscal Year: 1990
    ..of studies the animals will be pretreated by dietary manipulation, streptozotocin to produce diabetes and thyroidectomy, in order to alter the lipid composition of the inner mitochondrial membrane which, in turn, influences the ..
  10. A1-ADENOSINE RECEPTOR ACTION IN HIPPOCAMPUS
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate these studies will lead to new insights into the mechanisms of A1AR action. We also anticipate that these studies will identify A1ARs as an important regulator of axon growth. ..
  11. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..
  12. Scott A Rivkees; Fiscal Year: 2015
    ....
  13. DEVELOPING CIRCADIAN RHYTHMICITY
    Scott Rivkees; Fiscal Year: 2002
    ..These studies may also lead to the development of new care practices in Neonatal Intensive Care Units and extend the field of developmental chronobiology to the bedside. ..
  14. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
  15. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  16. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  17. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  18. The Role of Adenosine in Hypoglycemic Brain Injury
    Scott Rivkees; Fiscal Year: 2003
    ..We anticipate that these studies will yield new insights into the mechanisms of hypoglycemic brain injury and may lead to the development of practical strategies for reducing hypoglycemic brain injury. ..
  19. Mentored Patient-Oriented Research Career Development Award
    Jacqueline Jonklaas; Fiscal Year: 2006
    ..Participants will be euthyroid individuals scheduled for thyroidectomy for benign nodular disease or thyroid cancer...
  20. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2007
    ..Pearce's career as an independent academic clinical investigator with a focus on thyroid disease and epidemiology. ..
  21. Assessment and Validation of Tongue Fatigue for Speech
    NANCY SOLOMON; Fiscal Year: 2004
    ..This aim will provide evidence to support the clinical relevance of the exacerbation of dysarthria by fatigue and further validate the constant-effort technique as an indicator of fatigue. ..
  22. Biology of Headpin (a novel serpin) in Oral Cancer
    Gary Clayman; Fiscal Year: 2006
    ..Progress in this area could lead to development of new molecular based targets for the management of oral cancer. ..
  23. SLC2A9, A Candidate ER GLUT in Normal and Cancer Cells
    Jeffrey Moley; Fiscal Year: 2002
    ..Identification of SLC2A9 as the endoplasmic reticulum glucose transporter will improve understanding of GSDs, and of glucose metabolism in benign and malignant tissues. ..
  24. A NEURAL TRANSCRIPTION FACTOR IN LUNG CANCER EVOLUTION
    Douglas Ball; Fiscal Year: 2006
    ..The proposed studies should provide novel insights in SCLC biology and a firm basis for determining whether hASH1, and hASHl-regulated growth mechanisms, should be intensively pursued as therapeutic targets for SCLC. ..
  25. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2010
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  26. Imageable Mouse Models of Pancreatic Cancer
    Michael Bouvet; Fiscal Year: 2008
    ..Using such dual-colored imaging techniques, a better characterization of the tumor-host interactions in pancreatic cancer can be made. ..
  27. Targeting Bone Remodeling For the Treatment of Osteoporosis
    John Bilezikian; Fiscal Year: 2008
    ..The purpose of this meeting is to bring together experts from these interdisciplinary fields so as to define the direction of the future. ..
  28. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  29. MECHANISMS OF ESTROGEN RECEPTOR REGULATION
    Ronald J Weigel; Fiscal Year: 2010
    ..In the future it may be possible to develop a novel therapeutic to induce hormone response in breast cancers by specifically targeting the AP2 pathway. ..
  30. Feedback and Hormonal Regulation of Hepatic HMG-CoA Reductase
    GENE CHARLES NESS; Fiscal Year: 2010
    ....
  31. UW Stipends for Training Aspiring Researchers (STAR)
    Michael Portman; Fiscal Year: 2008
    ..increasing the numbers of underrepresented minority investigators involved in heart, lung, blood, and sleep disorder research. ..
  32. Thyrotropin Receptor Auto Antibodies in Graves' Ophthalmopathy
    Rebecca S Bahn; Fiscal Year: 2010
    ..Our studies will yield information concerning mechanisms involved in disease development, and will determine the effectiveness of a novel approach to therapy. ..
  33. SYMPATHETIC EXCITATORY RESPONSE AT BIRTH
    JEFFREY SEGAR; Fiscal Year: 2001
    ....
  34. ESTROGEN RECEPTOR CONTROL AND FUNCTION IN BREAST CANCER
    RONALD WEIGEL; Fiscal Year: 2001
    ..This will be accomplished by cloning and sequencing cDNAs of novel ER-regulated genes and characterizing primary breast tumors for expression of these genes. ..
  35. Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2008
    ..Besides surgery, there are limited curative and palliative treatments available to patients with metastatic NE tumors, emphasizing the need for development of other forms of therapy. [unreadable] [unreadable] [unreadable]..
  36. FcR Mutations in Kawasaki Disease
    Michael Portman; Fiscal Year: 2008
    ....
  37. Thyroid Hormone Receptor Isoform-Specific Actions
    Gregory Brent; Fiscal Year: 2008
    ..abstract_text> ..
  38. Fetal Cardiac Hypertrophy: Vascular/Metabolic Adaptation
    JEFFREY SEGAR; Fiscal Year: 2004
    ..The end result is hoped to be that the infant with a more 'normal' heart and circulatory physiology will have improved survival with less morbidity. ..
  39. Nuclear cofactors in Human Thyroid Disease
    Roy Weiss; Fiscal Year: 2007
    ..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..
  40. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2007
    ..unreadable]..
  41. Thyrocytes Express Inflammatory Mediators
    Andrew Gianoukakis; Fiscal Year: 2006
    ..The candidate will develop the scientific knowledge base, problem solving abilities, and technical skills which will allow him to develop into a independent physician/scientiist. ..
  42. EYE IN GRAVES DISEASE--ROLE OF ORBITAL FIBROBLASTS
    Rebecca Bahn; Fiscal Year: 2004
    ..The main goal of the research program is to increase understanding of the orbital immune response in GO in order that novel and more specific therapeutic and preventive strategies for this condition might be developed. ..
  43. Signaling Pathways in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2004
    ..abstract_text> ..
  44. Fetal Programming of Coronary Artery Disease
    JEFFREY SEGAR; Fiscal Year: 2005
    ..Only when the causes and mechanisms of hypertension and cardiovascular disease are understood in the context of a developmental process will it be possible to develop strategies for primary prevention. ..
  45. Thyroid Hormone Receptor Isoforms & Coactivators In Vivo
    Roy Weiss; Fiscal Year: 2005
    ..Such information would generate important leads in understanding the specific mechanistic aspects of TH action. ..
  46. Novel Signaling Targets in GI Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2005
    ..The possibility that raf-l-mediated hormone suppression could be induced by a soluble factor would provide a plausible, therapeutic delivery method. ..
  47. MYOCYTE REMODELING IN HEART FAILURE
    ANTHONY GERDES; Fiscal Year: 2004
    ..These studies will fill a critical void in our understanding of the cellular and molecular mechanisms underlying a key pathophysiologic cellular alteration that contributes to, or may actually cause, heart failure. ..