parathyroidectomy

Summary

Summary: Excision of one or both of the parathyroid glands.

Top Publications

  1. ncbi Is total parathyroidectomy the treatment of choice for hyperparathyroidism in multiple endocrine neoplasia type 1?
    Francesco Tonelli
    Department of Clinical Physiopathology, University of Florence, Medical SchoolFlorence, Italy
    Ann Surg 246:1075-82. 2007
  2. pmc Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the third international workshop
    John P Bilezikian
    Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Endocrinol Metab 94:335-9. 2009
  3. doi Bone mineral density analysis in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 after total parathyroidectomy
    Flavia L Coutinho
    Endocrine Genetics Unit LIM 25, Division of Endocrinology, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Clin Endocrinol (Oxf) 72:462-8. 2010
  4. ncbi Results of initial operation for hyperparathyroidism in patients with multiple endocrine neoplasia type 1
    Dina M Elaraj
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Surgery 134:858-64; discussion 864-5. 2003
  5. ncbi Parathyroid surgery in familial hyperparathyroid disorders
    T Carling
    Department of Surgery, Yale University School of Medicine, New Haven, CT, USA
    J Intern Med 257:27-37. 2005
  6. ncbi Osteoporosis in multiple endocrine neoplasia type 1: severity, clinical significance, relationship to primary hyperparathyroidism, and response to parathyroidectomy
    J R Burgess
    Department of Diabetes, Royal Hobart Hospital, Australia
    Arch Surg 134:1119-23. 1999
  7. doi Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop
    Shonni J Silverberg
    Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH 8W 864, New York, New York 10032, USA
    J Clin Endocrinol Metab 94:351-65. 2009
  8. pmc Parathyroidectomy decreases systolic and diastolic blood pressure in hypertensive patients with primary hyperparathyroidism
    Aliya Heyliger
    Division of General Internal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Surgery 146:1042-7. 2009
  9. doi Long-term effects of parathyroidectomy on hypertension prevalence and circadian blood pressure profile in primary hyperparathyroidism
    Carlos A Feldstein
    Hypertension Program, Hospital de Clinicas Jose de San Martin, School of Medicine, Universidad de Buenos Aires, Buenos Aires 1120, Argentina
    Clin Exp Hypertens 32:154-8. 2010
  10. pmc The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years
    Mishaela R Rubin
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 93:3462-70. 2008

Detail Information

Publications373 found, 100 shown here

  1. ncbi Is total parathyroidectomy the treatment of choice for hyperparathyroidism in multiple endocrine neoplasia type 1?
    Francesco Tonelli
    Department of Clinical Physiopathology, University of Florence, Medical SchoolFlorence, Italy
    Ann Surg 246:1075-82. 2007
    The aim of the present report is to describe the results obtained with total parathyroidectomy (TPTX) guided by rapid intraoperative parathyroid hormone (PTH) evaluation, followed by immediate parathyroid autograft with fresh tissue.
  2. pmc Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the third international workshop
    John P Bilezikian
    Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Endocrinol Metab 94:335-9. 2009
    ..Asymptomatic primary hyperparathyroidism (PHPT) is a common clinical problem. The purpose of this report is to guide the use of diagnostics and management for this condition in clinical practice...
  3. doi Bone mineral density analysis in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 after total parathyroidectomy
    Flavia L Coutinho
    Endocrine Genetics Unit LIM 25, Division of Endocrinology, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Clin Endocrinol (Oxf) 72:462-8. 2010
    Limited data have been reported on the effect of parathyroidectomy (PTx) on bone mineral density (BMD) in the setting of patients with hyperparathyroidism (HPT) associated with multiple endocrine neoplasia type 1 (MEN1)...
  4. ncbi Results of initial operation for hyperparathyroidism in patients with multiple endocrine neoplasia type 1
    Dina M Elaraj
    Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Surgery 134:858-64; discussion 864-5. 2003
    ..neoplasia type 1 (MEN1) is characterized by multiglandular disease and a propensity for recurrence after parathyroidectomy (PTx). This study analyzes outcomes of a cohort of MEN1 patients undergoing initial PTx at one institution.
  5. ncbi Parathyroid surgery in familial hyperparathyroid disorders
    T Carling
    Department of Surgery, Yale University School of Medicine, New Haven, CT, USA
    J Intern Med 257:27-37. 2005
    ..Multiple endocrine neoplasia type 1 (MEN1) is treated with either subtotal parathyroidectomy or total parathyroidectomy with immediate heterotopic autotransplantation of parathyroid tissue...
  6. ncbi Osteoporosis in multiple endocrine neoplasia type 1: severity, clinical significance, relationship to primary hyperparathyroidism, and response to parathyroidectomy
    J R Burgess
    Department of Diabetes, Royal Hobart Hospital, Australia
    Arch Surg 134:1119-23. 1999
    ..hyperparathyroidism associated with MEN 1 is typically recurrent, despite initially successful subtotal parathyroidectomy. Osteoporosis is considered a complication of sporadic PHPT and an indication for parathyroidectomy...
  7. doi Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop
    Shonni J Silverberg
    Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH 8W 864, New York, New York 10032, USA
    J Clin Endocrinol Metab 94:351-65. 2009
    ..We present the results of a literature review on issues arising from the clinical presentation and natural history of PHPT...
  8. pmc Parathyroidectomy decreases systolic and diastolic blood pressure in hypertensive patients with primary hyperparathyroidism
    Aliya Heyliger
    Division of General Internal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Surgery 146:1042-7. 2009
    ..The purpose of this study was to determine the effect of parathyroidectomy on systolic and diastolic blood pressures (BP) in hypertensive patients with PHPT.
  9. doi Long-term effects of parathyroidectomy on hypertension prevalence and circadian blood pressure profile in primary hyperparathyroidism
    Carlos A Feldstein
    Hypertension Program, Hospital de Clinicas Jose de San Martin, School of Medicine, Universidad de Buenos Aires, Buenos Aires 1120, Argentina
    Clin Exp Hypertens 32:154-8. 2010
    ..of hypertension in patients with primary hyperparathyroidism (PHPT), previously and after follow-up of parathyroidectomy. A group of 46 consecutive patients with sporadic PHPT due to adenoma undergoing surgery were followed an ..
  10. pmc The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years
    Mishaela R Rubin
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 93:3462-70. 2008
    ..We previously reported that calciotropic indices and bone mineral density (BMD) are stable in untreated patients for up to a decade, whereas after parathyroidectomy, normalization of biochemistries and increases in BMD ensue.
  11. pmc Prospective study of surgery for primary hyperparathyroidism (HPT) in multiple endocrine neoplasia-type 1 and Zollinger-Ellison syndrome: long-term outcome of a more virulent form of HPT
    Jeffrey A Norton
    Department of Surgery, Stanford University Medical Center, Stanford, CA 94305, USA
    Ann Surg 247:501-10. 2008
    ..Surgery for parathyroid hyperplasia is tricky and difficult. Long-term outcome in ZES/MEN1/HPT is not well known...
  12. doi Validity and limits of intraoperative parathyroid hormone monitoring during minimally invasive parathyroidectomy: a 10-year experience
    Alexandra Ozimek
    Chirurgische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Surg Endosc 24:3156-60. 2010
    ..of intraoperative intact parathyroid hormone monitoring allows the success of minimally invasive parathyroidectomy to be ensured during the operation...
  13. ncbi Parathyroidectomy rates among United States dialysis patients: 1990-1999
    Bryan Kestenbaum
    University of Washington Department of Medicine, Division of Nephrology, Seattle, Washington 98195, USA
    Kidney Int 65:282-8. 2004
    ..It is not known how changes in medical therapy might impact the parathyroidectomy (PTX) rate among dialysis patients...
  14. ncbi Endoscopic parathyroidectomy
    Ahmad Assalia
    Department of Surgery, Mount Sinai Medical Center, New York, NY 10029, USA
    Otolaryngol Clin North Am 37:871-86, xi. 2004
    This article describes the techniques of endoscopic and endoscopic assisted parathyroidectomy, with a special emphasis on the accumulated experience as well as the advantages and drawbacks of these novel techniques.
  15. ncbi Vitamin D metabolites and skeletal consequences in primary hyperparathyroidism
    B Moosgaard
    Aarhus Bone and Mineral Research Group Department of Endocrinology and Metabolism C, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Endocrinol (Oxf) 68:707-15. 2008
    ..However, successful parathyroidectomy causes an increase in BMD especially at sites rich in trabecular bone...
  16. ncbi Subtotal parathyroidectomy as an adequate treatment for primary hyperparathyroidism in multiple endocrine neoplasia type 1
    Johnathan G H Hubbard
    Department of Endocrine Surgery, University Hospital La Timone, Marseille, France
    Arch Surg 141:235-9. 2006
    ..It has been advocated that reoperations for recurrent disease are easier to perform after total parathyroidectomy (TP) with autotransplantation than after subtotal parathyroidectomy (SP)...
  17. ncbi Consequences of targeted parathyroidectomy guided by localization studies without intraoperative parathyroid hormone monitoring
    Denise M Carneiro-Pla
    Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA
    J Am Coll Surg 202:715-22. 2006
    ....
  18. doi Surgery for asymptomatic primary hyperparathyroidism: proceedings of the third international workshop
    Robert Udelsman
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Endocrinol Metab 94:366-72. 2009
    ..An international workshop on primary hyperparathyroidism (PHPT) was convened on May 13, 2008, to review and update the previous summary statement on the management of asymptomatic PHPT published in 2002...
  19. pmc Six hundred fifty-six consecutive explorations for primary hyperparathyroidism
    Robert Udelsman
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Surg 235:665-70; discussion 670-2. 2002
    To review the outcomes of 656 consecutive parathyroid explorations performed by a single surgeon and to compare the results of conventional and minimally invasive parathyroidectomy (MIP) techniques.
  20. doi Coronary microvascular dysfunction induced by primary hyperparathyroidism is restored after parathyroidectomy
    Elena Osto
    Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padua, Italy
    Circulation 126:1031-9. 2012
    ..However, data on the association between asymptomatic PHPT and cardiovascular risk are lacking. We assessed coronary flow reserve (CFR) as a marker of coronary microvascular function in asymptomatic PHPT of recent onset...
  21. doi Minimally invasive radioguided parathyroidectomy for hyperparathyroidism
    Yoshifumi Ikeda
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Ann Nucl Med 24:233-40. 2010
    ..In patients with HPT who meet the indications for parathyroidectomy, complete surgical resection of all hyperfunctioning parathyroid tissue is essential for the curative ..
  22. ncbi The outcome of subtotal parathyroidectomy for the treatment of hyperparathyroidism in multiple endocrine neoplasia type 1
    J R Burgess
    Department of Diabetes and Endocrine Services, Royal Hobart Hospital, Australia
    Arch Surg 133:126-9. 1998
    The efficacy of subtotal parathyroidectomy for the treatment of hyperparathyroidism in multiple endocrine neoplasia type 1 (MEN 1) is unclear. The long-term outcome and optimal timing of operation remain controversial.
  23. ncbi A very high incidence of low 25 hydroxy-vitamin D serum concentration in a French population of patients with primary hyperparathyroidism
    P Boudou
    Department of Hormonal Biology, Hopital Saint Louis, Paris, France
    J Endocrinol Invest 29:511-5. 2006
    ....
  24. ncbi Elucidating mechanisms of recurrent laryngeal nerve injury during thyroidectomy and parathyroidectomy
    Samuel K Snyder
    Department of Surgery, Scott and White Memorial Hospital, Temple, TX 76508, USA
    J Am Coll Surg 206:123-30. 2008
    Intraoperative nerve monitoring during thyroidectomy, parathyroidectomy, or related central neck procedures can elucidate actual or potential mechanisms of recurrent laryngeal nerve (RLN) injury, especially visually intact nerves, which ..
  25. ncbi Comparison of intraoperative iPTH assay (QPTH) criteria in guiding parathyroidectomy: which criterion is the most accurate?
    Denise M Carneiro
    DeWitt Daughtry Family Department of Surgery, University of Miami Jackson Memorial, PO Box 016310 M 875, Miami, FL 33101, USA
    Surgery 134:973-9; discussion 979-81. 2003
    ..To improve specificity or to decrease the cost of QPTH, several criteria have been used to predict complete excision. This study compares the Miami criterion with other published QPTH criteria in predicting operative outcome...
  26. ncbi Advantages of recurrent laryngeal nerve identification in thyroidectomy and parathyroidectomy and the importance of preoperative and postoperative laryngoscopic examination in more than 1000 nerves at risk
    Martin Steurer
    Department of Otorhinolaryngology Head and Neck Surgery, Vienna Medical School, General Hospital Vienna, Waeringer Guertel 18 20, A 1090 Vienna, Austria
    Laryngoscope 112:124-33. 2002
    ..Besides, misdiagnosis is not uncommon. Therefore, preoperative and postoperative laryngoscopic examination was given attention...
  27. ncbi Bisphosphonates can reduce bone hunger after parathyroidectomy in patients with primary hyperparathyroidism and osteitis fibrosa cystica
    Tatiana Clementino Pinto Toscano de França
    Centro de Osteoporose de Pernambuco, Department of Endocrinology, Hospital Agamenon Magalhães SUS, Universidade de Pernambuco, Recife, PE, Brazil
    Rev Bras Reumatol 51:131-7. 2011
    To assess the effect of bisphosphonates on post-parathyroidectomy hypocalcemia in patients with osteitis fibrosa cystica.
  28. doi Pulse wave velocity in primary hyperparathyroidism and effect of surgical therapy
    Jan Rosa
    3rd Department of Internal Medicine, General Faculty Hospital, First Medical Faculty, Charles University, Prague, Czech Republic
    Hypertens Res 34:296-300. 2011
    ..Subsequently, we examined the effect of parathyroidectomy (PTX) on arterial stiffness...
  29. ncbi Early parathyroidectomy increases bone mineral density in patients with mild primary hyperparathyroidism: a prospective and randomized study
    Erik G Almqvist
    Department of Medicine, Central Hospital, SE 541 85 Skövde, Sweden
    Surgery 136:1281-8. 2004
    ..This prospective and randomized study was undertaken to evaluate skeletal effects of delayed surgical treatment in such patients...
  30. ncbi Recurrent renal hyperparathyroidism caused by parathyromatosis
    Susumu Matsuoka
    Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    World J Surg 31:299-305. 2007
    ..In renal HPT, the stimuli of the parathyroid cells persist after parathyroidectomy (PTx), and for this reason, parathyromatosis might be important in renal HPT.
  31. ncbi Parathyroid surgical failures with sufficient decline of intraoperative parathyroid hormone levels: unobserved multiple endocrine neoplasia as an explanation
    Johan Westerdahl
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Arch Surg 141:589-94. 2006
    ..A sufficient decline in levels of parathyroid hormone measured intraoperatively (ioPTH) precludes early and late surgical failures...
  32. doi High success rate of parathyroid reoperation may be achieved with improved localization diagnosis
    Ola Hessman
    Department of Surgery, University Hospital, 751 85 Uppsala, Swede
    World J Surg 32:774-81; discussion 782-3. 2008
    ..We report the use of consistently applied localization diagnosis to yield high success rates in parathyroid reoperations...
  33. doi Evolution of maxillofacial brown tumors after parathyroidectomy in primary hyperparathyroidism
    Jaime Alonso Reséndiz-Colosia
    Department of Head and Neck Surgery, Hospital de Oncologia, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    Head Neck 30:1497-504. 2008
    Brown tumor occasionally affects the facial bones. Clinically, these lesions can be mistaken for a neoplasm. Opinions are divided on the course of management of the bony lesions once parathyroidectomy has been carried out.
  34. doi The superiority of minimally invasive parathyroidectomy based on 1650 consecutive patients with primary hyperparathyroidism
    Robert Udelsman
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06525, USA
    Ann Surg 253:585-91. 2011
    To compare the results of minimally invasive parathyroidectomy (MIP) and conventional parathyroid surgery.
  35. pmc Cardiac function in mild primary hyperparathyroidism and the outcome after parathyroidectomy
    P Farahnak
    Section of Surgery, Department of Clinical Science and Education, Karolinska Institutet Södersjukhuset, S 118 83 Stockholm, Sweden
    Eur J Endocrinol 163:461-7. 2010
    ..Using sensitive echocardiographic methods, we compared cardiac structure and function in patients with mild PHPT and in healthy controls, and evaluated the changes after parathyroidectomy (PTX).
  36. ncbi Incision length for standard thyroidectomy and parathyroidectomy: when is it minimally invasive?
    Laurent Brunaud
    Department of Surgery, University of California, San Francisco, USA
    Arch Surg 138:1140-3. 2003
    Current techniques for open conventional thyroidectomy or parathyroidectomy have evolved to enable a shorter incision (main proposition), and the length of the incision is influenced by objective factors.
  37. ncbi Malignant thymic carcinoid is not prevented by transcervical thymectomy in multiple endocrine neoplasia type 1
    J R Burgess
    Department of Diabetes, Royal Hobart Hospital, Tasmania, Australia
    Clin Endocrinol (Oxf) 55:689-93. 2001
    ..This is the first report of a malignant thymic carcinoid occurring in an MEN 1 patient following prior parathyroidectomy and transcervical thymectomy...
  38. doi Minimally invasive parathyroidectomy using local anesthesia with intravenous sedation and targeted approaches
    Maisie L Shindo
    SUNY at Stony Brook, Stony Brook, NY 11794, USA
    Otolaryngol Head Neck Surg 138:381-7. 2008
    Minimally invasive parathyroidectomy (MIP) is generally performed under general anesthesia. This study evaluates the efficacy and safety of MIP performed under intravenous sedation with local anesthesia.
  39. doi Vitamin D3 deficiency is associated with late-onset hypocalcemia after minimally invasive parathyroidectomy in a vitamin D borderline area
    Brian Hung Hin Lang
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    World J Surg 34:1350-5. 2010
    ..We aimed to examine the clinicopathologic features and short-term outcomes of vitamin D(3)-deficient patients after minimally invasive parathyroidectomy (MIP).
  40. ncbi Minimally invasive focused parathyroidectomy without using intraoperative parathyroid hormone monitoring or gamma probe
    M Haciyanli
    Ataturk Training and Research Hospital, Second Surgery, Izmir, Turkey
    J Postgrad Med 55:242-6. 2009
    Minimally invasive parathyroidectomy (MIP) is widely used worldwide for the treatment of primary hyperparathyroidism (pHPT). It is usually combined with a perioperative adjunct for high success rate.
  41. ncbi Minimally invasive parathyroidectomy using cervical block: reasons for conversion to general anesthesia
    Tobias Carling
    Yale University School of Medicine, New Haven, CT 06510, USA
    Arch Surg 141:401-4; discussion 404. 2006
    We investigated the frequency and reasons for conversion from cervical block anesthesia to general anesthesia (GA) in patients undergoing minimally invasive parathyroidectomy for primary hyperparathyroidism.
  42. ncbi Hyperparathyroidism in hereditary syndromes: special expressions and special managements
    Stephen J Marx
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892 1802, USA
    J Bone Miner Res 17:N37-43. 2002
    ..Both cause hypercalcemia from birth and atypical HPT that always and uniquely persists after subtotal parathyroidectomy. Their HPT is likely polyclonal and nonneoplastic...
  43. ncbi Surgical treatment for primary hyperparathyroidism in Hong Kong: changes in clinical pattern over 3 decades
    Chung Yau Lo
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong
    Arch Surg 139:77-82; discussion 82. 2004
    ..The clinical pattern of primary HPT has undergone a significant evolution in Western countries. A similar change can be documented in a geographic region where this condition is considered to be relatively uncommon...
  44. ncbi Long-term results of less than total parathyroidectomy for hyperparathyroidism in multiple endocrine neoplasia type 1
    Laurent C Arnalsteen
    Department of General and Endocrine Surgery, University Hospital of Lille, 1 rue Michel Polonovski, 59037 Lille Cedex, France
    Surgery 132:1119-24; discussion 1124-5. 2002
    Our aim was to assess long-term results after less than total parathyroidectomy for hyperparathyroidism in multiple endocrine neoplasia type 1.
  45. doi An 18-month open-label trial of teriparatide in patients with previous parathyroidectomy at continued risk for osteoporotic fractures: an exploratory study
    Barry S Horowitz
    Metabolic Research Institute, Inc, West Palm Beach, FL, USA
    Endocr Pract 17:377-83. 2011
    To determine whether teriparatide increases lumbar spine bone mineral density (BMD) in patients who have undergone parathyroidectomy for primary hyperparathyroidism (PHPT) and are at continued risk for fracture.
  46. doi Randomized clinical trial comparing open with video-assisted minimally invasive parathyroid surgery for primary hyperparathyroidism
    O Hessman
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
    Br J Surg 97:177-84. 2010
    Previous studies of video-assisted techniques for parathyroidectomy in patients with primary hyperparathyroidism have found similar or better results compared with bilateral neck exploration...
  47. ncbi Persistent parathyroid hormone elevation following curative parathyroidectomy for primary hyperparathyroidism
    Elizabeth A Mittendorf
    Department of Surgery, MetroHealth Medical Center, 2500 MetroHealth Dr, H920, Cleveland, OH 44109 1998, USA
    Arch Otolaryngol Head Neck Surg 128:275-9. 2002
    Persistent elevation of parathyroid hormone (PTH) levels following parathyroidectomy may indicate residual abnormal parathyroid tissue.
  48. doi Elevated parathyroid hormone levels after parathyroidectomy for primary hyperparathyroidism
    Aviram Mizrachi
    Department of Otorhinolaryngology Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Head Neck 31:1456-60. 2009
    Curative parathyroidectomy is associated with elevated levels of parathyroid hormone (PTH) with eucalcemia. This study sought to determine the frequency, clinical significance, and risk factors of this finding.
  49. ncbi Quick intraoperative parathyroid hormone assay: surgical adjunct to allow limited parathyroidectomy, improve success rate, and predict outcome
    George L Irvin
    DeWitt Daughtry Family Department of Surgery, University of Miami Jackson Memorial Hospital, P O Box 016310 M 875, Miami, FL 33101, USA
    World J Surg 28:1287-92. 2004
    ..The QPTH-guided limited parathyroidectomy (LPX) must be able to identify multiglandular disease (MGD), predict a successful outcome, and have a low ..
  50. ncbi Randomized clinical trial comparing regional and general anaesthesia in minimally invasive video-assisted parathyroidectomy
    P Miccoli
    Department of Surgery, Ospedale Santa Chiara, University of Pisa, Italy
    Br J Surg 92:814-8. 2005
    This randomized clinical trial was performed in a single institution to compare the results of minimally invasive video-assisted parathyroidectomy (MIVAP) conducted under regional anaesthesia (RA) or general anaesthesia (GA).
  51. doi Reoperative parathyroidectomy: an algorithm for imaging and monitoring of intraoperative parathyroid hormone levels that results in a successful focused approach
    Tina W F Yen
    Section of Endocrine Surgery, Division of General Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Surgery 144:611-9; discussion 619-21. 2008
    ..and use of intraoperative parathyroid hormone (IOPTH) levels are changing the approach to reoperative parathyroidectomy (ReopPTX)...
  52. ncbi Risks and consequences of incidental parathyroidectomy during thyroid resection
    Rebecca S Sippel
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    ANZ J Surg 77:33-6. 2007
    ..Inadvertent removal of the parathyroid glands during elective thyroid surgery occurs more frequently in certain high-risk patients and can lead to symptomatic hypocalcaemia...
  53. ncbi Rapid intraoperative immunoassay of parathyroid hormone and other hormones: a new paradigm for point-of-care testing
    Lori J Sokoll
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Chem 50:1126-35. 2004
    ..of the use of a rapid assay for the measurement of intact parathyroid hormone (PTH) in patients undergoing parathyroidectomy for hyperparathyroidism was reported in 1988...
  54. ncbi Incidental parathyroidectomy during thyroid surgery: an underappreciated complication of thyroidectomy
    George H Sakorafas
    Department of Surgery, 251 Hellenic Air Force Hospital, 19 21 Arkadias Street, Athens, GR 115 26, Greece
    World J Surg 29:1539-43. 2005
    The aim of this study was to investigate the incidence, risk factors, and clinical relevance of incidental parathyroidectomy during thyroid surgery...
  55. doi Minimally invasive parathyroidectomy: benefits and requirements of localization, diagnosis, and intraoperative PTH monitoring. long-term results
    Douglas L Fraker
    Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    World J Surg 33:2256-65. 2009
    Surgery is the only curative treatment for primary hyperparathyroidism. Initial parathyroidectomy procedures fail due to ectopic gland location and unappreciated multigland disease.
  56. doi Evaluation for concomitant thyroid nodules and primary hyperparathyroidism in patients undergoing parathyroidectomy or thyroidectomy
    Shane Y Morita
    Endocrine Surgery Section, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Surgery 144:862-6; discussion 866-8. 2008
    ..In this article, we present a single-center experience with the incidence of concomitant thyroid nodular disease and primary hyperparathyroidism in patients who underwent parathyroidectomy or thyroidectomy.
  57. ncbi Evaluation of serum calcium levels in predicting hypoparathyroidism after total/near-total thyroidectomy or parathyroidectomy
    D J Bentrem
    Division of Gastrointestinal and Endocrine Surgery, Northwestern University Medical School, Chicago, Illinois, USA
    Am Surg 67:249-51; discussion 251-2. 2001
    ..We analyzed 120 consecutive patients having total/near-total thyroidectomy and/or parathyroidectomy between April 1998 and October 1999...
  58. ncbi Evaluation of the performance and clinical impact of a rapid intraoperative parathyroid hormone assay in conjunction with preoperative imaging and concise parathyroidectomy
    L R Johnson
    Washington University School of Medicine, Department of Pathology and Immunology, Barnes-Jewish Hospital, St. Louis, MO 63110, USA
    Clin Chem 47:919-25. 2001
    ..stay, and pre- and postoperative calcium values were compared between a group of 49 patients undergoing parathyroidectomy where the intraoperative PTH assay was used in conjunction with preoperative imaging, and a historical ..
  59. ncbi Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism
    Tetsuhiko Sato
    Department of Surgery, Renal Center, Nagoya Second Red Cross Hospital, Nagoya, Japan
    Am J Kidney Dis 44:481-7. 2004
    ..The aim of this study is to examine the association of advanced secondary hyperparathyroidism with circulating FGF-23 levels...
  60. ncbi Medical observation, compared with parathyroidectomy, for asymptomatic primary hyperparathyroidism: a prospective, randomized trial
    Jens Bollerslev
    Section of Endocrinology, Department of Medicine, Rikshospitalet Radiumhospitalet Medical Center, National University Hospital, N 0027 Oslo, Norway
    J Clin Endocrinol Metab 92:1687-92. 2007
    ..The clinical presentation of primary hyperparathyroidism (pHPT) has changed during the last half century, and the diagnosis is now more often made by chance in patients with no specific symptoms...
  61. ncbi Fracture risk after parathyroidectomy among chronic hemodialysis patients
    Kyle D Rudser
    Division of Biostatistics, Harborview Medical Center, University of Washington, Seattle, WA 98104 2499, USA
    J Am Soc Nephrol 18:2401-7. 2007
    The impact of parathyroidectomy (PTX) on the long-term risks for hip and other fractures is unknown. Uncontrolled case series have reported an increase in bone mineral density after PTX...
  62. doi Surgery for multiple endocrine neoplasia type 1-associated primary hyperparathyroidism
    J Waldmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg, Marburg, Germany
    Br J Surg 97:1528-34. 2010
    ..It is uncertain which operative procedure provides the best outcome with regard to long-term normocalcaemia...
  63. pmc Unilateral versus bilateral neck exploration for primary hyperparathyroidism: a prospective randomized controlled trial
    Anders Bergenfelz
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Ann Surg 236:543-51. 2002
    ..To compare unilateral and bilateral neck exploration for primary hyperparathyroidism in a prospective randomized controlled trial...
  64. doi Evaluation of Halle, Miami, Rome, and Vienna intraoperative iPTH assay criteria in guiding minimally invasive parathyroidectomy
    Marcin Barczynski
    Department of Endocrine Surgery, Jagiellonian University College of Medicine, 37 Pradnicka Street, 31 202, Krakow, Poland
    Langenbecks Arch Surg 394:843-9. 2009
    Intraoperative parathyroid hormone assay (IOPTH) has been used during minimally invasive parathyroidectomy (MIP) to predict operative success...
  65. ncbi Is intraoperative parathyroid hormone assay mandatory for the success of targeted parathyroidectomy?
    Alejandra Gil-Cárdenas
    Department of Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    J Am Coll Surg 204:286-90. 2007
    Minimally invasive parathyroidectomy has become the first surgical option for patients with primary hyperparathyroidism (HPT) in many places...
  66. ncbi The surgeon's armamentarium to the surgical treatment of primary hyperparathyroidism
    James A Lee
    Department of Surgery, College of Physicians and Surgeons of Columbia University, New York Presbyterian Hospital, New York, New York, USA
    J Surg Oncol 89:130-5. 2005
    b>Parathyroidectomy cures the vast majority of patients with primary hyperparathyroidism (HPT)...
  67. ncbi Reassessment of parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism after 2 preoperative localization studies
    Atul A Gawande
    Harvard School of Public Health, Boston, MA, USA
    Arch Surg 141:381-4; discussion 384. 2006
    ..with 2 localization studies showing the same single location of parathyroid disease, use of intraoperative parathyroid hormone (IOPTH) measurement does not significantly increase the success of minimally invasive parathyroidectomy.
  68. doi Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia
    Fabiana G Graciolli
    Nephrology Division, Department of Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Nephrol Dial Transplant 24:1416-21. 2009
    ..In addition, Runx2 has been detected in calcified arteries of CKD patients. However, the in vivo effect of phosphate and PTH on Runx2 expression remains unknown...
  69. ncbi Up-to-date on parathyroid carcinoma: analysis of an experience of 19 cases
    Maurizio Iacobone
    Endocrine Surgery Unit, Department of Surgical and Gastroenterological Sciences, University of Padua, School of Medicine, Padova, Italy
    J Surg Oncol 88:223-8. 2004
    ..Parathyroid carcinoma (PC) is a rare disease; experience with its management is limited. The aim of this retrospective study was to evaluate a relatively large series of patients suffering from PC...
  70. doi The optimal surgical treatment for primary hyperparathyroidism in MEN1 patients: a systematic review
    Jennifer M J Schreinemakers
    Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands
    World J Surg 35:1993-2005. 2011
    ..The optimal surgical approach for patients with primary hyperparathyroidism (pHPT) and multiple endocrine neoplasia 1 (MEN1) is controversial. We sought to determine the optimal type of surgery for pHPT in MEN1...
  71. ncbi Asymptomatic hyperparathyroidism: a medical misnomer?
    Nancy D Perrier
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard 444, Houston, TX 77030, USA
    Surgery 137:127-31. 2005
  72. ncbi Focused cervical exploration for primary hyperparathyroidism without intraoperative parathyroid hormone monitoring or use of the gamma probe
    Steven R Jacobson
    Division of Gastroenterologic and General Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    World J Surg 28:1127-31. 2004
    ..Further experience with this surgical approach seems warranted to determine the overall cure rate, operative morbidity, and the sensitivity and specificity of preoperative localization studies...
  73. ncbi Results of video-assisted parathyroidectomy: single institution's six-year experience
    Paolo Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    World J Surg 28:1216-8. 2004
    Endoscopic surgery for primary hyperparathyroidism (PHPT) started in 1996 with a parathyroidectomy performed by Michel Gagner...
  74. ncbi Surgery or surveillance for mild asymptomatic primary hyperparathyroidism: a prospective, randomized clinical trial
    Elena Ambrogini
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 92:3114-21. 2007
    It is unclear whether patients with asymptomatic primary hyperparathyroidism (PHPT) do better with parathyroidectomy (PTx) as compared with conservative medical management.
  75. doi Effect of treatment with depot somatostatin analogue octreotide on primary hyperparathyroidism (PHP) in multiple endocrine neoplasia type 1 (MEN1) patients
    Antongiulio Faggiano
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 69:756-62. 2008
    ....
  76. ncbi Intraoperative parathyroid hormone monitoring
    William B Inabnet
    Department of Surgery, Section of Endocrine Surgery, College of Physicians and Surgeons of Columbia University, New York Presbyterian Hospital, 161 Fort Washington Avenue, Room 820, New York, NY 10032, USA
    World J Surg 28:1212-5. 2004
    The principles of minimally invasive parathyroidectomy include the successful preoperative localization of a solitary adenoma, a targeted operative approach that does not disturb the normal parathyroid glands, and intraoperative ..
  77. ncbi Conventional bilateral cervical exploration versus open minimally invasive parathyroidectomy under local anaesthesia for primary hyperparathyroidism
    A Bergenfelz
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Br J Surg 92:190-7. 2005
    Minimally invasive parathyroidectomy (MIP) has been introduced for the treatment of patients with primary hyperparathyroidism (pHPT)...
  78. ncbi Randomized controlled clinical trial of surgery versus no surgery in patients with mild asymptomatic primary hyperparathyroidism
    D Sudhaker Rao
    Division Head, Bone and Mineral Metabolism, Department of Internal Medicine, Henry Ford Hospital, Room E 1607, 2799 West Grand Boulevard, Detroit, Michigan 48202 2689, USA
    J Clin Endocrinol Metab 89:5415-22. 2004
    b>Parathyroidectomy is the definitive therapy for patients with symptomatic primary hyperparathyroidism. However, the role of surgery in mild asymptomatic primary hyperparathyroidism remains controversial...
  79. ncbi Metabolic abnormalities in patients with normocalcemic hyperparathyroidism detected at a population-based screening
    Emil Hagström
    Endocrine Unit, Department of Surgical Sciences, Uppsala University, University Hospital, SE 751 85 Uppsala, Sweden
    Eur J Endocrinol 155:33-9. 2006
    ..aim was to explore the occurrence of these metabolic abnormalities in individuals with normocalcemic pHPT identified in a population-based screening, and the effects of parathyroidectomy vs conservative treatment on metabolic variables.
  80. ncbi Minimally invasive parathyroidectomy without intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism
    R Mihai
    Department of Endocrine Surgery, John Radcliffe Hospital, Oxford, UK
    Br J Surg 94:42-7. 2007
    Minimally invasive parathyroidectomy (MIP) is the preferred operation for patients with primary hyperparathyroidism (HPT) and positive preoperative imaging...
  81. doi Outpatient minimally invasive parathyroidectomy is safe for elderly patients
    Susanna H Shin
    Department of Surgery, Eastern Virginia Medical School, Norfolk, VA, USA
    J Am Coll Surg 208:1071-6. 2009
    ..Because PHPT is more common in the elderly, we sought to compare indications and complications of minimally invasive parathyroidectomy in patients 70 years of age and older (elderly) with their younger counterparts.
  82. ncbi Minimally invasive parathyroidectomy using the lateral focused mini-incision technique without intraoperative parathyroid hormone monitoring
    T Pang
    University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia
    Br J Surg 94:315-9. 2007
    Minimally invasive parathyroidectomy (MIP) involves scan-directed removal of a single adenoma through a 2.0-cm mini-incision without intraoperative monitoring...
  83. ncbi Hyperparathyroidism in patients over 80: clinical characteristics and their ability to undergo outpatient parathyroidectomy
    Douglas Politz
    Norman Endocrine Surgery Clinic, Tampa, Florida 33613, USA
    Thyroid 17:333-9. 2007
    ..We evaluated the presentation of patients over 80 with primary hyperparathyroidism (PHPT) and their ability to tolerate outpatient, minimally invasive parathyroidectomy.
  84. doi What is the clinical significance of an elevated parathyroid hormone level after curative surgery for primary hyperparathyroidism?
    Li Ning
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, and the University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA
    Ann Surg 249:469-72. 2009
    ..To determine the clinical significance of ePTH and if it is a potential risk factor for recurrent HPT, we reviewed our experience...
  85. ncbi What is the link between nonlocalizing sestamibi scans, multigland disease, and persistent hypercalcemia? A study of 401 consecutive patients undergoing parathyroidectomy
    Bill Chiu
    Department of Surgery, Division of Gastrointestinal and Endocrine Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Surgery 140:418-22. 2006
    ..We hypothesized that nonlocalizing sestamibi scans would correlate with multigland disease and persistent primary hyperparathyroidism...
  86. doi Focused approach to parathyroidectomy
    Tobias Carling
    Department of Surgery, Yale University School of Medicine, 330 Cedar Street, FMB 102, Box 208062, New Haven, CT 06510, USA
    World J Surg 32:1512-7. 2008
    Minimally invasive parathyroidectomy is performed after preoperative parathyroid localization-usually with high-quality sestamibi scans and/or ultrasonography-often under cervical block anesthesia during which a limited exploration is ..
  87. ncbi Video-assisted parathyroidectomy via the lateral approach vs conventional surgery in the treatment of sporadic primary hyperparathyroidism: results of a case-control study
    J F Henry
    Department of General and Endocrine Surgery, University Hospital La Timone, Boulevard Jean Moulin, 13385 Marseilles Cedex 5, France
    Surg Endosc 15:1116-9. 2001
    We previously demonstrated that minimally invasive video-assisted parathyroidectomy (VAP) can be performed via a lateral approach on the line of the sternocleidomastoid muscle...
  88. ncbi Minimally invasive video-assisted parathyroidectomy versus open minimally invasive parathyroidectomy for a solitary parathyroid adenoma: a prospective, randomized, blinded trial
    Marcin Barczynski
    Department of Endocrine Surgery, 3rd Chair of General Surgery, Jagiellonian University College of Medicine, 37 Pradnicka Street, Krakow, 31 202, Poland
    World J Surg 30:721-31. 2006
    A variety of minimally invasive parathyroidectomy (MIP) techniques have been currently introduced to surgical management of primary hyperparathyroidism (pHPT) caused by a solitary parathyroid adenoma...
  89. pmc Effect of minimally invasive radioguided parathyroidectomy on efficacy, length of stay, and costs in the management of primary hyperparathyroidism
    R E Goldstein
    Divisions of Surgical Oncology and Endocrinology and the Department of Nuclear Medicine, Vanderbilt University Medical Center, and the Nashville VA Medical Center, Nashville, Tennessee 37232, USA
    Ann Surg 231:732-42. 2000
    ....
  90. pmc Radioguided parathyroidectomy for hyperparathyroidism in the reoperative neck
    Susan C Pitt
    Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA
    Surgery 146:592-8; discussion 598-9. 2009
    The purpose of this study was to determine if radioguided parathyroidectomy (RGP) is effective for hyperparathyroidism (HPT) in the reoperative neck.
  91. ncbi Management of calcium refilling post-parathyroidectomy in end-stage renal disease
    Mario Cozzolino
    Renal Unit, San Paolo Hospital, University of Milan, Milan, Italy
    J Nephrol 17:3-8. 2004
    Management of post-parathyroidectomy hypocalcemia in dialysis patients is not well defined. We reviewed published approaches to treatment in an effort to define a clinical algorithm for controlling serum calcium levels post-operatively.
  92. ncbi The fall and rise of parathyroidectomy in U.S. hemodialysis patients, 1992 to 2002
    Robert N Foley
    Chronic Disease Research Group, Minneapolis Medical Research Foundation, MN 55404, USA
    J Am Soc Nephrol 16:210-8. 2005
    ..the therapeutic approach to managing hyperparathyroidism has changed dramatically, it is unknown whether parathyroidectomy rates continue to decline in the United States...
  93. doi Minimally invasive video-assisted parathyroidectomy (MIVAP) for secondary hyperparathyroidism: report of initial experience
    Piero F Alesina
    Klinik für Chirurgie und Zentrum für Minimal Invasive Chirurgie, Kliniken Essen Mitte, Akademisches Lehrkrankenhaus der Universität Duisburg Essen, Essen, Germany
    Am J Surg 199:851-5. 2010
    Minimally invasive video-assisted parathyroidectomy (MIVAP) has become a well-accepted procedure for patients with primary hyperparathyroidism...
  94. doi Intraoperative laryngeal nerve monitoring during thyroidectomy and parathyroidectomy: A prospective study
    N Julien
    Service d ORL et de Chirurgie Cervico faciale, Hopital Beaujon, AP HP, 100 Boulevard du General Leclerc, Clichy, France Clinique Bizet, 21 rue Georges Bizet, Paris, France
    Eur Ann Otorhinolaryngol Head Neck Dis 129:69-76. 2012
    The aim of this study was to stimulate the recurrent laryngeal nerve during thyroidectomy or parathyroidectomy and to record the muscle responses in an attempt to predict postoperative vocal fold mobility.
  95. pmc Improved long-term survival of dialysis patients after near-total parathyroidectomy
    Jyotirmay Sharma
    Department of Surgery, Emory University, Atlanta, GA 30322, USA
    J Am Coll Surg 214:400-7; discussion 407-8. 2012
    ..The aim of this study was to compare short- and long-term mortality in dialysis patients who underwent near-total parathyroidectomy (NTPTX) and matched nonoperated controls.
  96. doi How does the operative strategy for primary hyperparathyroidism impact the findings and cure rate? A comparison of 800 parathyroidectomies
    Julie McGill
    Department of Surgery, Division of Gastrointestinal and Endocrine Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Am Coll Surg 207:246-9. 2008
    We hypothesized that a higher frequency of multigland disease and higher cure rate would result if routine four-gland exploration (4GL) was used as compared with focused parathyroidectomy (FP) for treatment of primary hyperparathyroidism.
  97. doi Mild primary hyperparathyroidism: vitamin D deficiency and cardiovascular risk markers
    Parastou Farahnak
    Section of Surgery, Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, Stockholm, Sweden
    J Clin Endocrinol Metab 96:2112-8. 2011
    ..The extent and clinical significance of cardiovascular (CV) abnormalities associated with mild primary hyperparathyroidism (PHPT) are still matters for discussion...
  98. pmc Radioguided parathyroidectomy is equally effective for both adenomatous and hyperplastic glands
    Herbert Chen
    University of Wisconsin Medical School Department of Surgery, H4 750 CSC 600 Highland Avenue, Madison, WI, USA
    Ann Surg 238:332-7; discussion 337-8. 2003
    To determine the utility of radioguided parathyroidectomy for patients with hyperparathyroidism, we studied the properties of 180 resected, hyperfunctioning parathyroid glands.
  99. ncbi Association between increased serum osteoprotegerin levels and improvement in bone mineral density after parathyroidectomy in hemodialysis patients
    Cai Mei Zheng
    Division of Nephrology, Department of Medicine, Taipei Medical University Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
    Tohoku J Exp Med 226:19-27. 2012
    ..HD patients with refractory SHPT can benefit from parathyroidectomy (PTX) treatment, but the changes of serum OPG, bone turnover markers and bone mineral density (BMD) ..
  100. doi Bone formation by minimodeling is more active than remodeling after parathyroidectomy
    Aiji Yajima
    Department of Nephrology, Towa Hospital, Adachi ku, Tokyo, Japan
    Kidney Int 74:775-81. 2008
    ..In patients undergoing parathyroidectomy for secondary hyperparathyroidism, we compared the contribution of minimodeling to remodeling during the ..
  101. ncbi [Radio-guided parathyroidectomy: successful intraoperative parathyroid localization diagnosis with 99mTc-sestamibi in primary and recurrent hyperparathyroidism]
    B Geissler
    , Klinikum Augsburg
    Chirurg 72:1179-85. 2001
    ..0 to 1.2 in undetected adenomas. In 67% of these patients we performed a minimally invasive open parathyroidectomy. In two cases of recurrent HPT the scan-guided detection of ectopic parathyroid tissue was efficient...

Research Grants32

  1. Non-Classical Manifestations of Primary Hyperparathyroidism
    Shonni J Silverberg; Fiscal Year: 2013
    ..in cardiovascular structure or function in patients with asymptomatic PHPT are reversible after parathyroidectomy. SA2b...
  2. Skeletal Regulation of Cortical and Trabecular Bone by Parathyroid Hormone
    Natalie Cusano; Fiscal Year: 2013
    ..or HypoPT before and after correction of the abnormal PTH state, either by normalization of PTH levels by parathyroidectomy (PHPT) or by administration of PTH (HypoPT)...
  3. GENETIC LINKAGE MAPPING OF FAMILIAL BENIGN HYPERCALCEMIA
    Hunter Heath; Fiscal Year: 1991
    ..Subtotal parathyroidectomy does not mitigate the biochemical abnormalities...
  4. REGULATION OF PARATHYROID HORMONE AND CALCITONIN GENES
    Justin Silver; Fiscal Year: 1991
    ..iii) After unilateral parathyroidectomy there is marked compensatory hyperplasia of the contralateral parathyroid...
  5. DISORDERS OF MINERAL METABOLISM IN CHILDREN
    Thomas Carpenter; Fiscal Year: 2003
    ..study indicated successful suppression of autonomous hyperparathyroidism in 4 XLH patients considered for parathyroidectomy. Thus, a controlled trial evaluating efficacy and safety of 24,25(OH)2D3 in the management of autonomous ..
  6. INTERACTION OF ORAL CALCIUM WITH POTASSIUM IN HYPERTENSI
    JACOB PEULER; Fiscal Year: 1999
    ..1,25D protects arteries from loss of EC relaxing activity during sustained culture in 1.25D free medium. Parathyroidectomy, which markedly lowers 1,25D, impairs arterial EC relaxing activity in hypertensive rats...
  7. SPECIALIZED CENTER OF RESEARCH IN OSTEOPOROSIS
    Robert Lindsay; Fiscal Year: 2002
    ..in post-menopausal women to characterize the effects of chronically increased PTH, and its reduction (after parathyroidectomy) on skeletal homeostasis...
  8. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2010
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  9. Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2008
    ..Besides surgery, there are limited curative and palliative treatments available to patients with metastatic NE tumors, emphasizing the need for development of other forms of therapy. [unreadable] [unreadable] [unreadable]..
  10. Novel Signaling Targets in GI Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2005
    ..The possibility that raf-l-mediated hormone suppression could be induced by a soluble factor would provide a plausible, therapeutic delivery method. ..
  11. Signaling Pathways in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2004
    ..abstract_text> ..
  12. PRIMARY HYPERPARATHYROIDISM: NON-CLASSICAL MANIFESTATIONS
    Shonni Silverberg; Fiscal Year: 2009
    ..abstract_text> ..
  13. Developing Biomarker-Based Prognostics In Breast Cancer
    John Olson; Fiscal Year: 2008
    ..abstract_text> ..
  14. Improving genomic prediction models in breast cancer
    John Olson; Fiscal Year: 2005
    ....
  15. Targeting Bone Remodeling For the Treatment of Osteoporosis
    John Bilezikian; Fiscal Year: 2008
    ..The purpose of this meeting is to bring together experts from these interdisciplinary fields so as to define the direction of the future. ..
  16. Extracellular matrix and protease markers of malignant thyroid neoplasm
    Electron Kebebew; Fiscal Year: 2007
    ..We will use these results to design a multicenter clinical trial evaluating the diagnostic and prognostic value of ECM1 and TMPRSS4 expression in patients with thyroid neoplasm. [unreadable] [unreadable] [unreadable]..
  17. The long-term consequences of postoperative acute kidney injury
    Areef Ishani; Fiscal Year: 2008
    ..Once the AKI- associated burden of CKD has been precisely estimated and modifiable factors have been identified, clinical trials can be performed that may reduce this disease burden. [unreadable] [unreadable] [unreadable]..
  18. EARLY HUSBANDRY INFLUENCES ON ADULT PHENOTYPE
    MICHAEL TORDOFF; Fiscal Year: 2009
    ..The results will lead to better environmental controls in future work and, asa direct consequence, easierand more rapid progress with genetic analyses. ..
  19. Pharmacokinetics & Genomics in Glomerular Diseases
    MELANIE JOY; Fiscal Year: 2008
    ..The selection of collaborators with expertise in the areas of this grant will enhance the career development of Dr. Joy. ..
  20. Regulation of SMAD4 and BMPR1A Expression in Juvenile Polyposis
    James R Howe; Fiscal Year: 2010
    ..abstract_text> ..
  21. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ....
  22. Mineral Metabolism and Cardiovascular Risk among Older Adults
    Bryan Kestenbaum; Fiscal Year: 2009
    ..Proposed analyses aim to clarify the roles of individual mineral markers with respect to CV health among older adults and to pave the way for future trials that target these markers as a means to improve CV outcomes. ..
  23. REGULATION OF BONE TURNOVER IN RENAL OSTEODYSTROPHY
    M Langub; Fiscal Year: 2003
    ..Altogether, the study and training will foster long term scientific productivity in the trainee's chosen field of bone pathology and biology. ..
  24. Cardiac Outcomes Associated with Renal Osteodystrophy
    Bryan Kestenbaum; Fiscal Year: 2007
    ..The proposed study aims to shed light on the relationship between a common renal related metabolic disorder and the epidemic burden of CVD found among this patient population. ..
  25. Tools for mapping transcriptional networks
    Uri Alon; Fiscal Year: 2006
    ..We expect that the analysis tools and concepts developed in E. coli will be very useful in mapping complex regulatory circuits in other cell types. [unreadable] [unreadable]..
  26. Influence of Tumor Immunogenicity to Immunotherapy
    Jeffrey Norton; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  27. Biology of Headpin (a novel serpin) in Oral Cancer
    Gary Clayman; Fiscal Year: 2006
    ..Progress in this area could lead to development of new molecular based targets for the management of oral cancer. ..
  28. The Molecular Basis of Juvenile Polyposis
    James Howe; Fiscal Year: 2005
    ..These studies will also benefit JP patients by improving presymptomatic genetic testing, and identification of new therapeutic targets for polyp regression and cancer prevention in JP. ..
  29. Coronary calcification in hemodialysis patients
    William Goodman; Fiscal Year: 2005
    ....
  30. PET Imaging of the Pancreas in Murine Models of Diabetes
    Paige Clark; Fiscal Year: 2005
    ..The method could also be useful in evaluating the function of pancreatic transplants and successful engraftment of transplanted progenitor or beta cells. ..
  31. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
    ..abstract_text> ..