ovariectomy

Summary

Summary: The surgical removal of one or both ovaries.

Top Publications

  1. pmc Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss
    Melda Onal
    Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Biol Chem 287:29851-60. 2012
  2. pmc Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity
    Nicole H Rogers
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Obesity and Metabolism, Boston, Massachusetts 02111, USA
    Endocrinology 150:2161-8. 2009
  3. ncbi The hormonal control of uterine luminal fluid secretion and absorption
    N Salleh
    Division of Reproductive Health, Endocrinology and Development, Guy s Campus, King s College, London, SE1 1UL, UK
    J Membr Biol 206:17-28. 2005
  4. ncbi Stimulation of bone formation in vitro and in rodents by statins
    G Mundy
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA
    Science 286:1946-9. 1999
  5. ncbi Oestrogen changed cardiomyocyte contraction and beta-adrenoceptor expression in rat hearts subjected to ischaemia-reperfusion
    Qin Wu
    Department of Physiology, Xuzhou Medical College, West Huaihai Road 84, Xuzhou, Jiangsu 221002, China
    Exp Physiol 93:1034-43. 2008
  6. ncbi Low-magnitude high-frequency vibration treatment augments fracture healing in ovariectomy-induced osteoporotic bone
    Hong Fei Shi
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Bone 46:1299-305. 2010
  7. pmc The laboratory rat as an animal model for osteoporosis research
    Pavlos P Lelovas
    Laboratory for Research of the Musculoskeletal System, School of Medicine, University of Athens, Greece
    Comp Med 58:424-30. 2008
  8. pmc The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1
    Amutha Selvamani
    Women s Health in Neuroscience Program, Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, Texas 77843, USA
    J Neurosci 30:6852-61. 2010
  9. ncbi Antidepressant-like effect of different estrogenic compounds in the forced swimming test
    Erika Estrada-Camarena
    Depto de Farmacobiología CINVESTAV IPN, Calzada de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, CP 14330 México DF, Mexico
    Neuropsychopharmacology 28:830-8. 2003
  10. ncbi Mice with increased angiogenesis and osteogenesis due to conditional activation of HIF pathway in osteoblasts are protected from ovariectomy induced bone loss
    Qiang Zhao
    Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese Western Medicine, Ruijin Hospital, Jiao Tong University School of Medicine, Shanghai 200025, People s Republic of China
    Bone 50:763-70. 2012

Detail Information

Publications401 found, 100 shown here

  1. pmc Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss
    Melda Onal
    Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Biol Chem 287:29851-60. 2012
    ..Herein, we examined whether RANKL expression in either B or T lymphocytes contributes to ovariectomy-induced bone loss in mice...
  2. pmc Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity
    Nicole H Rogers
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Obesity and Metabolism, Boston, Massachusetts 02111, USA
    Endocrinology 150:2161-8. 2009
    ..In summary, OVX in mice decreases energy expenditure, without altering energy intake, resulting in adipocyte hypertrophy, adipose tissue inflammation, and hepatic steatosis...
  3. ncbi The hormonal control of uterine luminal fluid secretion and absorption
    N Salleh
    Division of Reproductive Health, Endocrinology and Development, Guy s Campus, King s College, London, SE1 1UL, UK
    J Membr Biol 206:17-28. 2005
    ....
  4. ncbi Stimulation of bone formation in vitro and in rodents by statins
    G Mundy
    OsteoScreen, 2040 Babcock Road, San Antonio, TX 78229, USA
    Science 286:1946-9. 1999
    ..Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis...
  5. ncbi Oestrogen changed cardiomyocyte contraction and beta-adrenoceptor expression in rat hearts subjected to ischaemia-reperfusion
    Qin Wu
    Department of Physiology, Xuzhou Medical College, West Huaihai Road 84, Xuzhou, Jiangsu 221002, China
    Exp Physiol 93:1034-43. 2008
    ..Female Sprague-Dawley rats were subjected to bilateral ovariectomy (OVX) or sham operation (Sham)...
  6. ncbi Low-magnitude high-frequency vibration treatment augments fracture healing in ovariectomy-induced osteoporotic bone
    Hong Fei Shi
    Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Bone 46:1299-305. 2010
    ..Nine-month-old ovariectomy (OVX)-induced osteoporotic rats were randomized into control (OVX-C) or vibration group (OVX-V); age-matched ..
  7. pmc The laboratory rat as an animal model for osteoporosis research
    Pavlos P Lelovas
    Laboratory for Research of the Musculoskeletal System, School of Medicine, University of Athens, Greece
    Comp Med 58:424-30. 2008
    ..The rat has been used in many experimental protocols leading to bone loss, including hormonal interventions (ovariectomy, orchidectomy, hypophysectomy, parathyroidectomy), immobilization, and dietary manipulations...
  8. pmc The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1
    Amutha Selvamani
    Women s Health in Neuroscience Program, Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, Texas 77843, USA
    J Neurosci 30:6852-61. 2010
    ..These data support the hypothesis that stroke severity in older females is associated with decreased IGF-1 and further indicate that short-term postischemic IGF-1 therapy may be beneficial for stroke...
  9. ncbi Antidepressant-like effect of different estrogenic compounds in the forced swimming test
    Erika Estrada-Camarena
    Depto de Farmacobiología CINVESTAV IPN, Calzada de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, CP 14330 México DF, Mexico
    Neuropsychopharmacology 28:830-8. 2003
    ..The time course analysis of the actions of E(2) (10 microg/rat) and EE(2) (5 microg/rat) showed that both compounds induced an antidepressant-like effect observed 1 h after their injection lasting for 2-3 days...
  10. ncbi Mice with increased angiogenesis and osteogenesis due to conditional activation of HIF pathway in osteoblasts are protected from ovariectomy induced bone loss
    Qiang Zhao
    Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese Western Medicine, Ruijin Hospital, Jiao Tong University School of Medicine, Shanghai 200025, People s Republic of China
    Bone 50:763-70. 2012
    ..via osteoblast specific disruption of HIF degrading protein von Hippel-Lindau (VHL) (ΔVhl), are protected from ovariectomy induced bone loss...
  11. ncbi Anti-osteoporosis activity of Cibotium barometz extract on ovariectomy-induced bone loss in rats
    Xiong Zhao
    Department of Orthopeadics, Xijing Hospital, The Fourth Military Medical University, No 17 Changlexi Road, Xi an 710032, China
    J Ethnopharmacol 137:1083-8. 2011
    ..The purpose of this study is to systemically investigate the effects of Cibotium barometz extract (CBE) on ovariectomy-induced osteoporosis in rats.
  12. ncbi Experimental osteoporosis--different methods of ovariectomy in female white rats
    A Lasota
    Department of Cytophysiology, Histology and Embryology, Medical University of Lodz, Poland
    Rocz Akad Med Bialymst 49:129-31. 2004
    ..Rats are currently principal laboratory animals, used to investigate osteoporosis. The aim of the study was to present and compare two operative methods of inducing osteoporosis in rats...
  13. ncbi Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    Willscott E Naugler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, University of California, San Diego, CA 93093, USA
    Science 317:121-4. 2007
    ..We propose that estrogen-mediated inhibition of IL-6 production by KCs reduces liver cancer risk in females, and these findings may be used to prevent HCC in males...
  14. ncbi Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats
    Sridhar Muthusami
    Department of Endocrinology, Dr ALMPGIBMS, University of Madras, Taramani, Chennai, 600 113, India
    Clin Chim Acta 360:81-6. 2005
    ..We investigated the impact of ovariectomy (OVX) on the bone antioxidant system in rats.
  15. ncbi Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis
    Latha Devareddy
    Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA
    J Nutr Biochem 19:694-9. 2008
    ..In summary, our findings indicate that blueberry can prevent bone loss as seen by the increases in BMD and favorable changes in biomarkers of bone metabolism...
  16. ncbi Increased myocardial stiffness with maintenance of length-dependent calcium activation by female sex hormones in diabetic rats
    Tepmanas Bupha-Intr
    Faculty of Science, Department of Physiology, Mahidol University, Bangkok, Thailand
    Am J Physiol Heart Circ Physiol 300:H1661-8. 2011
    ..While ovariectomy had no effect on myocardial stiffness, collagen content, or titin ratio, a significant increase in myocardial ..
  17. pmc Chronic estradiol replacement to aged female rats reduces anxiety-like and depression-like behavior and enhances cognitive performance
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Life Sciences Research 1058, Albany, NY 12222, USA
    Psychoneuroendocrinology 34:909-16. 2009
    ..Thus, E(2)-replacement reduced anxiety and depression behavior and improved cognitive performance of aged female rats; however, delay in E(2) treatment influenced whether there were favorable effects of E(2) in some tasks...
  18. ncbi Medicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized mice
    Abdul M Tyagi
    Division of Endocrinology, Central Drug Research Institute Council of Scientific and Industrial Research, Chattar Manzil, P O Box 173, Lucknow, India
    Mol Cell Endocrinol 325:101-9. 2010
    ..Medicarpin exhibited no uterine estrogenicity. Our findings point towards direct and indirect inhibitory effects of medicarpin on osteoclastogenesis in vitro that contribute to its bone sparing effect in OVx mice...
  19. ncbi Relationship between age, skeletal site, and time post-ovariectomy on bone mineral and trabecular microarchitecture in rats
    Joy I Francisco
    Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    J Orthop Res 29:189-96. 2011
    ..The individual effects of rat age, skeletal site, and time post-ovariectomy (post-OVX) on bone have been examined. However, the relationship between them is not yet fully explored...
  20. ncbi Impact of estrogen replacement on ventricular myocyte contractile function and protein kinase B/Akt activation
    Jun Ren
    Division of Pharmaceutical Sciences, University of Wyoming College of Health Sciences, Laramie, WY 82071 3375, USA
    Am J Physiol Heart Circ Physiol 284:H1800-7. 2003
    ..Nulliparous female rats were subjected to bilateral ovariectomy (Ovx) or sham operation (sham). A subgroup of Ovx rats received estrogen (E(2)) replacement (40 microg. kg(-1)...
  21. ncbi The osteoprotective effect of Radix Dipsaci extract in ovariectomized rats
    Zhen Guo Liu
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    J Ethnopharmacol 123:74-81. 2009
    ..The objective of the present study was to systematically evaluate the effects of Radix Dipsaci extract (RDE) on postmenopausal osteoporosis...
  22. ncbi The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss
    Tae Ho Kim
    Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Jung Gu, Daegu 700 412, Republic of Korea
    J Nutr Biochem 22:8-15. 2011
    ..We further investigated the effects of luteolin on ovariectomy-induced bone loss using micro-computed tomography, biomechanical tests and serum markers assay for bone ..
  23. ncbi Estrogens maintain bone mass by regulating expression of genes controlling function and life span in mature osteoclasts
    Yuuki Imai
    Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    Ann N Y Acad Sci 1173:E31-9. 2009
    ..In conclusion, in osteoclasts, estrogens function to inhibit bone resorption activity and vitality rather than differentiation...
  24. pmc Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss
    Li Sun
    The Mount Sinai Bone Program and The Thyroid Research Unit at the Bronx Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:4289-94. 2008
    ..with the possible anabolic effects shown earlier, TSH both prevents bone loss and restores the lost bone after ovariectomy. Importantly, the osteoclast inhibitory action of TSH persists ex vivo even after therapy is stopped for 4 ..
  25. pmc A crucial role for thiol antioxidants in estrogen-deficiency bone loss
    Jenny M Lean
    Department of Cellular Pathology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom
    J Clin Invest 112:915-23. 2003
    ..the enzymes responsible for maintaining them in a reduced state, fell substantially in rodent bone marrow after ovariectomy and were rapidly normalized by exogenous 17-beta estradiol...
  26. ncbi Altered Ca(2+) handling by ryanodine receptor and Na(+)-Ca(2+) exchange in the heart from ovariectomized rats: role of protein kinase A
    Gennadi M Kravtsov
    Department of Physiology, 4 F Laboratory Block, Faculty of Medicine Bldgs, 21 Sassoon Rd, Pokfulam, Hong Kong SAR, China
    Am J Physiol Cell Physiol 292:C1625-35. 2007
    Our previous study has demonstrated that ovariectomy (Ovx) significantly increased the left ventricular developed pressure (LVDP) and the maximal rate of developed pressure over time (+/-dP/dt(max)) in the isolated perfused rat heart and ..
  27. ncbi Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum
    Tepmanas Bupha-Intr
    Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Am J Physiol Heart Circ Physiol 291:H1101-8. 2006
    ..Under hormone-deficient conditions, there was an adaptive response of SERCA that escaped the regulatory effect of phospholamban...
  28. ncbi Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium
    P Diel
    , Deutsche Sporthochschule, , Germany
    Hum Reprod 16:997-1006. 2001
    ....
  29. pmc Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids
    Maria Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    J Biol Chem 282:27285-97. 2007
    ..Loss of estrogens or androgens accelerates the effects of aging on bone by decreasing defense against oxidative stress...
  30. pmc Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance
    R E Stubbins
    Department of Nutritional Sciences, University of Texas at Austin, Austin, TX 78712, USA
    Diabetes Obes Metab 14:58-66. 2012
    ..Our aim was to assess the role oestrogen has in modulating adipocyte size, adipose tissue oxidative stress, inflammation, insulin resistance and liver steatosis...
  31. pmc Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females
    Claudia J Lagranha
    Translational Medicine Branch, NHLBI NIH 10 Center Bethesda, MD 20892, USA
    Circ Res 106:1681-91. 2010
    ..Although premenopausal females have a lower risk for cardiovascular disease, the mechanism(s) are poorly understood...
  32. ncbi Differences of three-dimensional trabecular microstructure in osteopenic rat models caused by ovariectomy and neurectomy
    M Ito
    Department of Radiology, Nagasaki University School of Medicine, Nagasaki, Japan
    Bone 30:594-8. 2002
    ..in three-dimensional microstructure of bone in cases of osteopenia caused by two different procedures: ovariectomy (ovx) and sciatic neurectomy (nx)...
  33. ncbi Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta
    Aina Martorell
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    Cardiovasc Res 84:300-8. 2009
    ....
  34. pmc Electrophysiological and neuroanatomical evidence of sexual dimorphism in aortic baroreceptor and vagal afferents in rat
    Bai Yan Li
    Department of Pharmacology, Harbin Medical University, Harbin, China
    Am J Physiol Regul Integr Comp Physiol 295:R1301-10. 2008
    ..7% vs. 3.8%, n = 169, P < 0.01), and ovariectomy does not alter its expression but does lessen neuronal excitability...
  35. ncbi Determining the optimal age for gonadectomy of dogs and cats
    Margaret V Root Kustritz
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
    J Am Vet Med Assoc 231:1665-75. 2007
    ..Increasingly, dog owners and members of the veterinary profession throughout the world have questioned the optimal age for performance of these procedures and whether these procedure should even be performed as elective surgeries...
  36. ncbi Tumor necrosis factor-alpha mediates osteopenia caused by depletion of antioxidants
    C J Jagger
    Department of Cellular Pathology, St George s Hospital Medical School, London SW17 0RE, United Kingdom
    Endocrinology 146:113-8. 2005
    ..We found that the loss of bone caused by either BSO administration or ovariectomy was inhibited by administration of soluble TNFalpha receptors and abrogated in mice deleted for TNFalpha gene ..
  37. pmc Implications of combined ovariectomy/multi-deficiency diet on rat bone with age-related variation in bone parameters and bone loss at multiple skeletal sites by DEXA
    Parameswari Govindarajan
    Laboratory of Experimental Trauma Surgery, Justus Liebig University, Department of Trauma Surgery, University Hospital of Giessen Marburg, Giessen, Germany
    Med Sci Monit Basic Res 19:76-86. 2013
    ..are imperative for disease diagnostics, the present study establishes and evaluates enhanced osteoporosis obtained through combined ovariectomy and deficient diet by DEXA (dual-energy X-ray absorptiometry) for a prolonged time period.
  38. ncbi Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
    J Biomech 40:1333-9. 2007
    ..Ideally, such mechanical signals represent a non-pharmacologic means of controlling bone mass and morphology in spite of systemic pressures for bone resorption...
  39. ncbi Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats
    Marina Komrakova
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch 40, 37075 Goettingen, Germany
    Bone 47:480-92. 2010
    ..In perspective, PTH may represent a treatment for enhancement of fracture healing. The findings need to be confirmed by follow-up studies on other animals...
  40. ncbi Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production
    R B Kimble
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 271:28890-7. 1996
    To analyze how estrogen blocks osteoclastogenesis, we investigated the effects of ovariectomy on osteoclast (OC) formation in co-cultures of purified OC precursors and purified stromal cells (SC)...
  41. ncbi Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation
    Jenny M Lean
    Department of Cellular Pathology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom
    Endocrinology 146:728-35. 2005
    ..We found that catalase prevented ovariectomy-induced bone loss...
  42. ncbi Effects of ovariectomy on bone metabolism and bone mineral density in spontaneously diabetic Torii-Lepr(fa) rats
    Shuichi Kimura
    Biological Pharmaceutical Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Takatsuki, Osaka 569 1125, Japan
    J Vet Med Sci 73:1025-9. 2011
    ..The objective of the present study was to investigate the effects of ovariectomy (OVX) on bone metabolism and bone mineral density (BMD) in the female SDT-fa/fa rat...
  43. ncbi Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys
    Peter R Rapp
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 23:5708-14. 2003
    ..Modest improvement was also observed on a delayed nonmatching-to-sample recognition memory task. In contrast, ovariectomy exacerbated age-related deficits in object discrimination learning; the magnitude of this effect was equivalent ..
  44. ncbi Reduced local blood supply to the tibial metaphysis is associated with ovariectomy-induced osteoporosis in mice
    Wen Ge Ding
    Department of Orthopaedics, Changzhou No 1 People s Hospital, Changzhou, China
    Connect Tissue Res 52:25-9. 2011
    ....
  45. ncbi In vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells
    Songlin Peng
    Department of Orthopaedics and Traumatology, The University of Hong Kong, Room 907, Lab Block, 21 Sassoon Road, Hong Kong SAR, China
    J Orthop Res 28:1208-14. 2010
    ..The effect of Sr on rat BMSCs was reproducible in human BMSCs. Taken together, this study suggests that the anabolic effect of Sr on normal or osteoporotic bones is associated with increased osteoblastic differentiation of BMSCs...
  46. pmc Dehydroepiandrosterone protects against oxidative stress-induced endothelial dysfunction in ovariectomized rats
    João Paulo Gabriel Camporez
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S ao Paulo, SP, Brazil
    J Physiol 589:2585-96. 2011
    ..The present results suggest an important action of DHEA, improving endothelial function in OVX rats by acting as an antioxidant and enhancing the NO bioavailability...
  47. ncbi Ovariectomy enhances SR Ca²⁺ release and increases Ca²⁺ spark amplitudes in isolated ventricular myocytes
    Elias Fares
    Department of Pharmacology, 5850 College Street, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    J Mol Cell Cardiol 52:32-42. 2012
    ..Ca(2+) homeostasis in ventricular myocytes from 8-month-old female C57BL/6J mice that had either a bilateral ovariectomy (OVX) or a sham surgery at 3 weeks of age...
  48. pmc Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption
    H Yoshitake
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3 10 Kanda Surugadai 2 Chome, Chiyoda ku, Tokyo, Japan
    Proc Natl Acad Sci U S A 96:8156-60. 1999
    ..We report here that osteopontin knockout mice are resistant to ovariectomy-induced bone resorption compared with wild-type mice...
  49. ncbi Cardioprotective effects of long-term treatment with raloxifene, a selective estrogen receptor modulator, on myocardial ischemia/reperfusion injury in ovariectomized rats
    Ming Ting Chung
    Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan
    Menopause 17:127-34. 2010
    ..The aim of this study was to investigate the beneficial effect of long-term treatment with raloxifene (RAL), a selective estrogen receptor modulator, on myocardial ischemia/reperfusion (MI/R) injury in ovariectomized (Ovx) rats...
  50. ncbi Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
    Alexander Elbaz
    Lady Davis Institute for Medical Research, McGill University, Montreal, QC H3T 1E2, Canada
    Biogerontology 10:747-55. 2009
    ..In addition, this evidence suggests that old individuals may show a better response to E2 administration in terms of reverting the high levels of marrow fat seen in age-related bone loss...
  51. pmc Effects of PTH treatment on tibial bone of ovariectomized rats assessed by in vivo micro-CT
    J E M Brouwers
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Osteoporos Int 20:1823-35. 2009
    ..Bone was formed in cavities, leading to restoral of nearly cleaved trabeculae. For the first time, effects in PTH-treated rats were analyzed longitudinally...
  52. pmc Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms
    Wipawee Winuthayanon
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Environ Health Perspect 117:1155-61. 2009
    ..Diarylheptanoids isolated from Curcuma comosa Roxb. have been recently identified as phyto estrogens. However, the mechanism underlying their actions has not yet been identified...
  53. ncbi Modulation of insulin resistance in ovariectomized rats by endurance exercise training and estrogen replacement
    Vitoon Saengsirisuwan
    Exercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Metabolism 58:38-47. 2009
    ..These findings indicate that 12 weeks of ovariectomy caused metabolic alterations mimicking features of the insulin resistance syndrome...
  54. ncbi Effects of α-tocopherol on the early phase of osteoporotic fracture healing
    Ahmad Nazrun Shuid
    Faculty of Medicine, Department of Pharmacology, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz 50300 KL, Malaysia
    J Orthop Res 29:1732-8. 2011
    ..The improvement in fracture healing may be due to the increased activities of the anti-oxidatant enzymes in the bone during the early phase of fracture healing of osteoporotic bone...
  55. ncbi Increased fat due to estrogen deficiency induces bone loss by elevating monocyte chemoattractant protein-1 (MCP-1) production
    Youn Young Kim
    Department of Biological Sciences Brain Korea 21 Program and the Immunomodulation Research Center, University of Ulsan, Ulsan, 680 749, Korea
    Mol Cells 29:277-82. 2010
    b>Ovariectomy (OVX)-induced estrogen withdrawal resulted in both bone loss and an increase in fat...
  56. pmc Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice
    Firas M Kara
    New York University School of Medicine, New York, NY, USA
    Arthritis Rheum 62:534-41. 2010
    ....
  57. ncbi Effects of repeated electroacupuncture on beta-endorphin and adrencorticotropic hormone levels in the hypothalamus and pituitary in rats with chronic pain and ovariectomy
    Jun ling Liu
    Department of Physiology, Institute of Acu moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
    Chin J Integr Med 16:315-23. 2010
    To explore the mechanism of electroacupuncture (EA)-induced cumulative analgesic effects on chronic pain in rats with or without ovariectomy (OVX).
  58. ncbi Strontium ranelate does not stimulate bone formation in ovariectomized rats
    R K Fuchs
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Osteoporos Int 19:1331-41. 2008
    ..We evaluated the effects of SrR on the skeleton in ovariectomized (OVX) rats and evaluated the influence of dietary calcium...
  59. pmc Ovariectomy-associated changes in bone mineral density and bone marrow haematopoiesis in rats
    Zhu Lei
    Department of Hematology, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China
    Int J Exp Pathol 90:512-9. 2009
    ..Our studies demonstrated a reciprocal correlation between bone-forming osteoblasts and marrow adipose tissue and suggest that OVX rats may be valuable as an animal model to study hypohaemopoiesis...
  60. pmc Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice
    Jenna C Carroll
    University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191
    Endocrinology 151:2713-22. 2010
    ..We found that ovariectomy-induced hormone depletion increases AD-like pathology in female 3xTg-AD mice, including accumulation of beta-..
  61. ncbi The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice
    S H Windahl
    Institute of Medicine, Sahlgrenska Academy, Goteborg University, Goteborg
    Am J Physiol Endocrinol Metab 296:E490-6. 2009
    ..These in vivo findings demonstrate that GPR30 is not required for normal estrogenic responses on several major well-known estrogen-regulated parameters. In contrast, GPR30 is required for a normal estrogenic response in the growth plate...
  62. ncbi The effect of L-arginine and L-NAME on pentylenetetrazole induced seizures in ovariectomized rats, an in vivo study
    Mahmoud Hosseini
    Dept of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Seizure 18:695-8. 2009
    ..This NO effect might be differing in the presence or absence of ovarian hormones, but further investigations need to be done...
  63. pmc Neuronal estrogen receptor-alpha mediates neuroprotection by 17beta-estradiol
    Joachim G Elzer
    Division of Molecular Biology of the Cell 1, German Cancer Research Center, Heidelberg, Germany
    J Cereb Blood Flow Metab 30:935-42. 2010
    ..We conclude that neuronal ER alpha in female and male mice mediates neuroprotective estrogen effects in an in vivo mouse model of stroke, whereas microglial ER alpha is dispensable...
  64. pmc Oophorectomy, menopause, estrogen, and cognitive aging: the timing hypothesis
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurodegener Dis 7:163-6. 2010
    ..The concept of neuroprotective effects of estrogen in women remains controversial...
  65. pmc Recovery of trabecular and cortical bone turnover after discontinuation of risedronate and alendronate therapy in ovariectomized rats
    Robyn K Fuchs
    Department of Anatomy and Cell Biology, Indiana University Medical School, Indianapolis, Indiana, USA
    J Bone Miner Res 23:1689-97. 2008
    ..Despite reductions in BMD and increases in bone turnover, ultimate force of the fifth lumbar vertebra remained significantly higher in all drug-treated animals through 16 wk after withdrawal...
  66. ncbi Rapid enhancement of visual and place memory by estrogens in rats
    Victoria N Luine
    Department of Psychology, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Endocrinology 144:2836-44. 2003
    ..Thus, these results provide the first demonstration of rapid memory enhancements by estrogen and implicate nongenomic mechanisms, possibly an extranuclear receptor(s), in mediating the response...
  67. pmc Improvement of trochanteric bone quality in an osteoporosis model after short-term treatment with parathyroid hormone: a new mechanical test for trochanteric region of rat femur
    M Tezval
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Osteoporos Int 21:251-61. 2010
    ..We have developed a reproducible biomechanical test and produced trochanteric fractures to evaluate stiffness and strength of this region in addition to histomorphometry...
  68. ncbi Effects of ovariectomy on PPAR alpha, SREBP-1c, and SCD-1 gene expression in the rat liver
    Amélie Paquette
    Département de Kinésiologie, Universite de Montreal, Montreal, Quebec, Canada
    Menopause 15:1169-75. 2008
    ..To investigate whether estrogen deficiency modifies the expression of important genes involved in hepatic lipid regulation, PPAR alpha, SREBP-1c, and SCD-1, in association with fat accumulation in the liver of ovariectomized rats...
  69. ncbi Estrogen-dependent abdominal hyperalgesia induced by ovariectomy in adult mice: a model of functional abdominal pain
    Raul Sanoja
    Anesthesia Research Unit Faculty of Medicine, Faculty of Dentistry and McGill Center for Pain Research, McGill University, Montreal, Quebec, Canada
    Pain 118:243-53. 2005
    ..abdominal pain in females we studied the time course and estrogen dependency of a hyperalgesic state induced by ovariectomy in adult mice...
  70. pmc Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity
    Eniko A Kramar
    Department of Psychiatry, University of California, Irvine, California 92697, USA
    J Neurosci 29:12982-93. 2009
    ..Finally, ovariectomy depressed RhoA activity, spine cytoskeletal plasticity, and LTP, whereas brief infusions of estrogen rescued ..
  71. pmc Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice
    S H Windahl
    Department of Biosciences, Karolinska Institute, Novum, S 14157 Huddinge, Sweden
    J Clin Invest 104:895-901. 1999
    b>Ovariectomy in young, growing rodents results in decreased trabecular bone mineral density (BMD) and increased radial growth of the cortical bone. Both of these effects are reversed by treatment with estrogen...
  72. ncbi Effects of ovariectomy and 17 beta-oestradiol replacement on [Ca2+]i in female rat cardiac myocytes
    Claire L Curl
    Department of Physiology, Monash University, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 30:489-94. 2003
    1. The present study investigated the effects of ovariectomy (OVX) and 17beta-oestradiol replacement on [Ca2+]i in rat freshly isolated cardiac myocytes. 2...
  73. ncbi Upregulation of beta 1-adrenergic receptors in ovariectomized rat hearts
    Ariyaporn Thawornkaiwong
    Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Life Sci 72:1813-24. 2003
    ..These results suggest a possible direct suppressive effect of ovarian sex hormones on the expression of cardiac beta(1)-adrenergic receptors...
  74. ncbi Hormonal activity of combinations of genistein, bisphenol A and 17beta-estradiol in the female Wistar rat
    Simone Schmidt
    Institut Kreislaufforschung und für Sportmedizin, Abt molekulare und zelluläre Sportmedizin, Deutsche Sporthochschule Koln, Carl Diem Weg 6, 50933 Cologne, Germany
    Arch Toxicol 80:839-45. 2006
    ..This is not the case for Gen. Our results point to the involvement of complex molecular mechanisms in the action of Gen. These mechanisms, especially the role of ERbeta have to be characterized in further investigations...
  75. ncbi Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    J Nutr Biochem 17:282-9. 2006
    ....
  76. ncbi Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells
    Kathryn Backholer
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Endocrinology 151:2233-43. 2010
    ..This network between the three cell types could coordinate brain control of reproduction and metabolic homeostatic systems...
  77. ncbi Regulation of Kiss1 gene expression in the brain of the female mouse
    Jeremy T Smith
    Department of Physiology and Biophysics, Health Sciences Building, G 424, School of Medicine, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Endocrinology 146:3686-92. 2005
    ..In the arcuate nucleus (Arc), KiSS-1 expression increased after ovariectomy and decreased with E2 treatment...
  78. ncbi The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin
    D L French
    Department of Radiology, McMaster University, Hamilton, Ontario, Canada
    Phytomedicine 15:1069-78. 2008
    ..Bone mineral density was measured at the spine, femur and whole body before and at 2, 4 and 6 months after ovariectomy in each of 40 mature rats...
  79. ncbi Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats
    R Zhang
    Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi an 710032, PR China
    Bone 45:553-9. 2009
    ..3-month-old female Sprague-Dawley rats were used and randomly assigned into sham-operated group (Sham) and five ovariectomy (OVX) subgroups, i.e...
  80. pmc PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    Toru Akune
    Department of Orthopaedic Surgery, University of Tokyo, Japan
    J Clin Invest 113:846-55. 2004
    ..The osteogenic effect of PPARgamma haploinsufficiency became prominent with aging but was not changed upon ovariectomy. The PPARgamma haploinsufficiency was confirmed to enhance osteoblastogenesis in the bone marrow cell culture ..
  81. ncbi The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening
    M S Mahendroo
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    Mol Endocrinol 13:981-92. 1999
    ....
  82. ncbi Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice
    Junko Mori-Okamoto
    School of Health and Social Services, Saitama Prefectural University, Saitama 343 8540, Japan
    J Ethnopharmacol 92:93-101. 2004
    ..Prolongation of the immobility time in forced swimming test, an index of depression, was measured 14 days after ovariectomy. The bone mineral density (BMD) of the tibia was measured by X-ray absorptiometry and the structure and ..
  83. ncbi Labisia pumila extract regulates body weight and adipokines in ovariectomized rats
    Mansor Fazliana
    Department of Molecular Medicine and Surgery, M1 03, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Maturitas 62:91-7. 2009
    ..alata (LPva), and compared to estrogen replacement (ERT), on body weight gain, uterus weight, adipose tissue mRNA and protein levels of adipokines in ovariectomized (OVX) rats...
  84. pmc Osteocyte apoptosis and control of bone resorption following ovariectomy in mice
    K B Emerton
    Department of Biomedical Engineering, The City College of New York, USA
    Bone 46:577-83. 2010
    ..of this study was to characterize the patterns of osteocyte apoptosis in relation to bone resorption following ovariectomy to test whether osteocyte apoptosis occurs preferentially in areas known to activate resorption...
  85. ncbi Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation
    Mario M Zaiss
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 62:2328-38. 2010
    ..The aim of this study was to determine whether immune regulatory mechanisms, such as naturally occurring Treg cells, also extend their protective effects to bone homeostasis in vivo...
  86. pmc Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Brain Res 1379:188-98. 2011
    ..Therefore, women who underwent bilateral oophorectomy before the onset of menopause or women who experienced premature or early natural menopause should be considered for hormonal treatment until approximately age 51 years...
  87. ncbi Protective actions of soy isoflavones and n-3 PUFAs on bone mass in ovariectomized rats
    Bruce A Watkins
    Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907 2009, USA
    J Nutr Biochem 16:479-88. 2005
    b>Ovariectomy (OVX) in female rats precipitates a marked reduction in endogenous estrogen concentrations and induces bone remodeling abnormalities that augment bone loss and increase the risk of developing osteopenia...
  88. ncbi Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland
    Michael D Johnson
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Nat Med 9:1081-4. 2003
    ..In utero exposure to the metal also mimicked the effects of estrogens. Female offspring experienced an earlier onset of puberty and an increase in the epithelial area and the number of terminal end buds in the mammary gland...
  89. ncbi 17Alpha-estradiol and 17beta-estradiol treatments are effective in lowering cerebral amyloid-beta levels in AbetaPPSWE transgenic mice
    Justine A Levin-Allerhand
    The Rockefeller University, New York, NY, USA
    J Alzheimers Dis 4:449-57. 2002
    ..Compared to sham ovariectomized mice, ovariectomy with placebo did not alter Abeta levels; however, the levels of Abeta were decreased by 27% and 38% in mice ..
  90. pmc High levels of estrogen enhance associative memory formation in ovariectomized females
    B Leuner
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, 152 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Psychoneuroendocrinology 29:883-90. 2004
    ..They are discussed with reference to hormone replacement and its effects on cognitive processes...
  91. ncbi Quality-of-life effects of prophylactic salpingo-oophorectomy versus gynecologic screening among women at increased risk of hereditary ovarian cancer
    Joanna B Madalinska
    Division of Psychosocial Research and Epidemiology, Department of Gynecology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 23:6890-8. 2005
    ..The aim of the current study was to determine the quality-of-life (QOL) effects of PBSO versus GS...
  92. pmc Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions
    Shotaro Suzuki
    Department of Physiology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 104:6013-8. 2007
    ..We report that E(2) exerts profound neuroprotective action when administered immediately upon ovariectomy, but not when administered after 10 weeks of hypoestrogenicity...
  93. ncbi Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats
    Michelle M Adams
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Henry L Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 22:3608-14. 2002
    ..Such a role for spinous ER-alpha has important implications for age-related attenuation of estrogen-induced hippocampal plasticity...
  94. ncbi Age differentially influences estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) gene expression in specific regions of the rat brain
    Melinda E Wilson
    Department of Physiology, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Mech Ageing Dev 123:593-601. 2002
    ..In summary, the expression of ERalpha and ERbeta mRNAs is differentially modulated in the aging brain and changes are region specific...
  95. ncbi Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection
    Louise D McCullough
    Department of Neurology and Anesthesiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 4961, USA
    J Neurosci 23:8701-5. 2003
    ....
  96. ncbi Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice
    Hye Kyeong Kim
    Department of Animal and Diary Science, Medical College of Georgia, Augusta, GA 30912, USA
    J Nutr 136:409-14. 2006
    ..Thus, genistein may be useful in treating or preventing increased adiposity after menopause...
  97. pmc Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator
    Simone Cenci
    Division of Endocrinology and Metabolism, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 100:10405-10. 2003
    ..Here we show that ovariectomy up-regulates IFN-gamma-induced class II transactivator, a multitarget immune modulator, resulting in increased ..
  98. ncbi Ovariectomy and 17beta-estradiol modulate disease progression of a mouse model of ALS
    G J Groeneveld
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, G 03 228, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Brain Res 1021:128-31. 2004
    ..We therefore determined the effect of ovariectomy on female G93A mSOD1 transgenic mice, and the effect of subsequent treatment with 17beta-estradiol (E2)...
  99. ncbi Non-genomic actions of estrogens and their interaction with genomic actions in the brain
    Nandini Vasudevan
    Cell and Molecular Biology Department, Tulane University, LA 70118, USA
    Front Neuroendocrinol 29:238-57. 2008
    ..The idea that coupling between membrane-initiated and genomic actions of hormones is a novel idea in neuroendocrinology and provides us with a unified view of hormone action in the central nervous system...
  100. ncbi A protective effect of Curcuma comosa Roxb. on bone loss in estrogen deficient mice
    Jittima Weerachayaphorn
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    J Ethnopharmacol 137:956-62. 2011
    ..Curcuma comosa Roxb. or Wan chak motluk is an indigenous medicinal herb and has traditionally been used among postmenopausal women for relief of unpleasant menopausal symptoms...
  101. pmc Extragonadal aromatization increases with time after ovariectomy in rats
    Hong Zhao
    Department of Neurobiology and Integrative Medicine, Institute of Acupuncture Research, WHO Collaborating Centre for Traditional Medicine, Shanghai Medical College of Fudan University, Shanghai, P R China
    Reprod Biol Endocrinol 3:6. 2005
    The circulating estrogen concentration elevated gradually along with time after ovariectomy in rats...

Research Grants65

  1. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..signaling in osteoclasts of pre-pubertal male and female PTP-oc transgenic mice, 2) evaluating the effects of ovariectomy and estrogen replacement on the osteoclastic phenotype of adult female PTP-oc transgenic mice, and 3) ..
  2. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..produg for E2, and is likely to be a safe and effective treatment of conditions due to the lack of estrogens (ovariectomy) or low levels of estrogens (menopause)...
  3. Endocrine Targets for Prevention of Lung Cancer
    Robert M Bigsby; Fiscal Year: 2012
    ..b>Ovariectomy abrogates these sex differences and estrogen treatment restores tumor number but not tumor grade, indicating ..
  4. Estrogens, androgens, aging, and bone loss in males
    Stavros C Manolagas; Fiscal Year: 2013
    ..of estradiol on osteoclasts and osteoblasts;and is as potent as estradiol in preventing oxidative stress and ovariectomy-induced bone loss, without affecting uterine weight...
  5. Neural Control of the Circulation: Sex and Hypertension
    Baojian Xue; Fiscal Year: 2013
    ..In addition, we find that ovariectomy (OVX) abolishes these female-related antihypertensive effects and that administration of estrogen or estrogen ..
  6. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2012
    ..b>Ovariectomy causes a significant fall in DA neuron number, while castration of males results in a surprising increase in ..
  7. The Role of Estradiol and Sex in the Effects of Ghrelin on Meal Patterns and Fos-
    PETER BUTERA; Fiscal Year: 2009
    ..are particularly striking in female rats, which show large increases in food intake and body weight after ovariectomy (Wade, 1975)...
  8. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..At maturity (150 days of age) the experimental rats will undergo ovariectomy surgery to 27 model post menopausal bone loss...
  9. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Physiological changes including menopause and ovariectomy induce irreversible changes in the cardiovascular system that frequently result in diminished endothelium-dependent regulation of vascular ..
  10. Interaction of Estrogen and AMPK in the Hypothalamus
    Jessica Healy; Fiscal Year: 2012
    ..presence and absence of estradiol, utilizing cell culture, transfection, Western blotting, quantitative RT-PCR, ovariectomy and intracerebroventricular injection...
  11. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    ..Aim 1 will determine if, after surgical menopause induced by ovariectomy, Val/Met mice experience even greater anxiety and memory problems and less BDNF signaling that Val/Val (control)..
  12. Impact of Estrogens and Menopause on Interacting Monoamine Neurotransmitters in t
    Jeffrey K Yao; Fiscal Year: 2013
    ..Models of menopause will include ovariectomy (a model of surgical menopause), and treatment with 4-vinylcyclohexene diepoxide (VCD;a model of natural ..
  13. Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapy
    Yu Zhang; Fiscal Year: 2012
    ..as a supplement or by injection prevented bone loss induced by mineral deficiency or estrogen deficiency (ovariectomy) in rats...
  14. Gender Specific Complications of Diabetic Autonomic Neuropathy: A New Mouse Model
    JONAS BERNARD GALPER; Fiscal Year: 2010
    ..Specifically, we will test the hypotheses 1) that ovariectomy of female Akita mice results in the development of the diabetic phenotype and secondary effects of diabetes as ..
  15. Low birth weight, the kidney, and hypertension
    Barbara T Alexander; Fiscal Year: 2013
    ..Importantly, castration abolishes hypertension in male IUGR;ovariectomy (OVX) induces a marked increase in blood pressure (BP) in female IUGR...
  16. Coloney Stimulating Factor 1 regulation and role in bone
    KARL LEONARD INSOGNA; Fiscal Year: 2010
    ..Surprisingly, following ovariectomy, sCSF-op/op mice lost significantly more bone than the mCSF1-op/op mice, suggesting that sCSF1 plays a more ..
  17. Gonadotropins in a female model of age-induced hypertension
    KATHRYN L SANDBERG; Fiscal Year: 2012
    ..We have previously shown that ovariectomy accelerates the age-induced increase in BP and BW in this model and that 172-estradiol (E2) prevents these ..
  18. Role of Mitochondria in Estrogen Action and Cellular Senescence
    Michael C Velarde; Fiscal Year: 2013
    ..cells;and (d) test the physiological impact of estrogen action during the aging process in skin by using an ovariectomy mouse model...
  19. Complement and Osteoporosis
    Feng Lin; Fiscal Year: 2013
    ..revealed that mice lacking the C3 component of the complement system were protected from bone loss after ovariectomy (OVX), as shown by micro-computed tomography (microCT) analysis...
  20. Estrogen: Neuroprotection in the Perimenopause
    Anne M Etgen; Fiscal Year: 2010
    ..at various intervals prior to insult, or ovariectomized and treated with estradiol at various intervals after ovariectomy. If estradiol does not preserve neurons and cognitive function in older hormone-deprived animals, we, will also ..
  21. Ginger Extracts in the Prevention of Metabolic Bone Disease
    LAURA ELIZABETH WRIGHT; Fiscal Year: 2011
    ..In the ovariectomy (OVX) model of postmenopausal osteoporosis, female Sprague Dawley rats will undergo sham-operation or OVX, and ..
  22. Functional Analysis of NHA-oc/NHA2 in vivo
    RICARDO ANIBAL BATTAGLINO; Fiscal Year: 2010
    ..For that, we will compare bone loss induced by ovariectomy in wild type and homozygous mutant mice...
  23. A Narrowed Window for Targeting Metabolic Flexibility in Breast Cancer Prevention
    Pepper J Schedin; Fiscal Year: 2013
    ..models of breast cancer (methylnitrosourea), obesity (obesity-prone rats) and menopause (surgical ovariectomy, OVX) were merged to create an experimental paradigm for studying obesity-associated tumor promotion after ..
  24. Mechanistic basis of probiotic prevention of osteoporosis
    Narayanan Parameswaran; Fiscal Year: 2013
    ..We have identified, for the first time that estrogen deficiency (induced by ovariectomy, ovx) leads to intestinal inflammation and causes dysbiosis of the intestinal microbiota in mice...
  25. Hepatic Estrogen Signaling and Protection Against Insulin Resistance
    MELISSA NICOLE MARTINEZ; Fiscal Year: 2013
    ..in the liver despite high-fat feeding and decreased insulin action to AKT, but that after surgical menopause by ovariectomy this protection from insulin resistance is lost...
  26. Harnessing mechanical signals to control mesenchymal stem cell fate
    JANET E RUBIN; Fiscal Year: 2013
    ..and scheduling suppresses the fat phenotype in mouse models of diet-induced obesity and estrogen deficiency (ovariectomy), achieved through the regulation of MSC activity, and the extent to which downstream complications of ..
  27. Mechanisms of estrogen action on bone marrow-derived stem stromal cells
    Charlotte Kuperwasser; Fiscal Year: 2011
    ..Moreover, it is well established that ovariectomy prevents the formation of both ER-positive as well as ER-negative breast cancers in women, further highlighting ..
  28. OVARIECTOMY UPREGULATES BONE TURNOVER THROUGH T CELL-STROMAL CROSSTALK
    Roberto Pacifici; Fiscal Year: 2012
    The cessation of estrogen (E) production induced by natural menopause or ovariectomy (ovx) is followed by a period of rapid bone loss which is instrumental for the development of postmenopausal osteoporosis...
  29. Postmenopausal Monkey Resource
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..We hypothesize that estrogen (E) replacement will be beneficial when started immediately after ovariectomy/hysterectomy (Ovx), but delayed treatment will have no beneficial, or even adverse, effects on many of the ..
  30. Translational Insights into Estrogen Receptor alpha-Positive Luminal Breast Cance
    ROBERT DAVID SCHREIBER; Fiscal Year: 2013
    ..JAK2-STAT3/5 signaling and gene expression in STAT1-/- ER?+ (luminal) mammary tumors that grow out following ovariectomy of tumor bearing mice, and explore the underlying mechanisms for this progression...
  31. Differential Impact of Resveratrol and Resveratrol Mimetics Upon Aging Bone
    Bruce R Troen; Fiscal Year: 2013
    ..this aim will answer the critical questions of whether or not in vivo RSV and SyRMs prevent age-related and/or ovariectomy-induced bone loss, whether RSV and SyRMs exert either anabolic and anti-resorptive effects on bone or both, and ..
  32. Role of FSH in Osreoclast Formation and Function
    Mone Zaidi; Fiscal Year: 2012
    ..We will also examine whether selective FSHR deletion in the osteoclast will prevent ovariectomy-induced bone loss, and whether transgenic reconstitution of the FSHR in FSHR-/- osteoclasts will restore ..
  33. Mechanisms of Hypovitaminosis D Pain: Role of Nociceptor Sprouting.
    SARAH ELIZABETH TAGUE; Fiscal Year: 2010
    ..Therefore the expression levels of these proteins will be examined in staged cycling and ovariectomy induced menopause rats...
  34. Role of Macrophage Migration Inhibitory Factor in Osteoclastogenesis
    Sun Kyeong Lee; Fiscal Year: 2013
    ..mice exhibited a high turnover osteoporotic bone phenotype and MIF deficient mice were protected from ovariectomy-induced bone loss. These studies imply that MIF plays an important role in the pathogenesis of osteoporosis...
  35. TSH and Bone
    Mone Zaidi; Fiscal Year: 2013
    ..we observed that TSH, when injected intermittently as far apart as once every two weeks, prevented and restored ovariectomy-induced bone loss by inhibiting bone resorption and stimulating bone formation...
  36. Ovariectomy Induced T Cell Inflammatory Cytokines/Bone Loss in Young & Old Mice
    Roberto Pacifici; Fiscal Year: 2010
    ....
  37. Estrogen regulation of channels involved in the control of energy homeostasis
    TROY ADAM ROEPKE; Fiscal Year: 2010
    ..homeostasis through ER? and mER because STX, a selective ligand for the mER, attenuates body weight gain post-ovariectomy. Estradiol also alters neuronal excitability of POMC arcuate neurons through the mER...
  38. High-resolution ex vivo micro-computerized tomography system
    Mary F Barbe; Fiscal Year: 2010
    ..of genetically engineered mice (transgenic and knockout models), pathological bone remodeling (such as after ovariectomy and low calcium diet), and after head trauma fracture...
  39. Black Bear Parathyroid Hormone as an Anabolic Agent for Bone
    SETH WARNER DONAHUE; Fiscal Year: 2011
    ..perform a dose-response study in ovariectomized mice to evaluate the efficacy of bear PTH 1-84 at reversing ovariectomy induced bone loss...
  40. Intracranial Aneurysm Pathogenesis-Roles of Vascular Remodeling and Inflammation
    Tomoki Hashimoto; Fiscal Year: 2013
    ..Our preliminary data using a newly developed mouse model of intracranial aneurysm show that ovariectomy (surgical menopause) increased the incidence of intracranial aneurysms in female mice...
  41. Hormonal Regulation of Fat Deposition
    Jonathan M Graff; Fiscal Year: 2013
    ..By integrating surgical (ovariectomy), pharmacological (estrogen), and genetic (adipose lineage specific estrogen receptor knockouts) manipulations, ..
  42. Role of GPR30 in Mediating Estrogen Effects on Neurons and Cognitive Performance
    REBECCA L HAMMOND; Fiscal Year: 2012
    ..This aim was recently completed, and G-1 was found to reverse the effects of ovariectomy on acquisition of a delayed matching to position T- maze task, similar to the effects of estradiol (Hammond et ..
  43. G-protein coupled receptor EBI2 regulation of bone mass
    Erin Nevius; Fiscal Year: 2013
    ..in vitro are defective in size and EBI2 deficiency results in increased bone density and protects mice from ovariectomy- induced osteoporosis...
  44. Regulation of hemopoietic stem cell expansion by calciotrophic hormones
    Roberto Pacifici; Fiscal Year: 2013
    ..by applicant): The goal of this application is to determine how T lymphocytes increase the capacity of ovariectomy (ovx) and parathyroid hormone (PTH) to expand hemopoietic stem cells (HSCs)...
  45. The Role Of Osteoclast PODXL, A Mediator Of Cell Adhesion, In Bone Metabolism
    Merry Jo Oursler; Fiscal Year: 2013
    ..We will comprehensively phenotype the hem lineage-PODXLdel mice, establish the effects of ovariectomy on bone metabolism in hem lineage-PODXLdel mice, define the impact of loss of PODXL in early osteoclast lineage ..
  46. The Roles of Collagen and Water in the Fracture Resistance of Bone
    JEFFRY STEPHEN NYMAN; Fiscal Year: 2013
    ..type-2 diabetes on the fracture resistance of bone and 2) the protective effect of bisphosphonate treatment on ovariectomy-induced decrease in fracture resistance...
  47. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2013
    ..are sensitive to estrogen (E2), giving rise to increased risk of hypertension following menopause or surgical ovariectomy. Supported by my preliminary results showing for the first time that caveolar trafficking modulates SKS channel ..
  48. Osteocyte Integrity and Bone Remodeling
    Mitchell B Schaffler; Fiscal Year: 2012
    ..resorption previously established for remodeling of microdamage in bone hold as well for resorption induced by ovariectomy and disuse...
  49. Development of an animal model to study how to prevent progression of hormone dep
    Gudmundur Thordarson; Fiscal Year: 2009
    ..MNU)-induced rat mammary cancers either become impalpable or show more than 50% reduction in size after ovariectomy, a high percentage of these tumors show re-growth with prolonged time after ovariectomy...
  50. Estrogen regulation of channels involved in the control of energy homeostasis
    TROY ADAM ROEPKE; Fiscal Year: 2013
    ..homeostasis through ERa and mER because STX, a selective ligand for the mER, attenuates body weight gain post-ovariectomy. Estradiol also alters neuronal excitability of POMC arcuate neurons through the mER...
  51. Repair of large osteoporotic rat calvarial defects with autologous adipose stem c
    Ming Pei; Fiscal Year: 2012
    ..A total of eighty 6-month-old female Sprague-Dawley rats will be randomly assigned into either the ovariectomy group (n=40) or the sham operation group (n=40)...
  52. Role of GPR30 in Mediating Estrogen Effects on Neurons and Cognitive Performance
    REBECCA L HAMMOND; Fiscal Year: 2011
    ..Preliminary data suggest G-1 reverses effects of ovariectomy on acquisition of a delayed matching-to-position T-maze task, similar to the effects of estradiol...
  53. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..Hearts from female (q ovariectomy (OVX)), and male (q orchiectomy (ORX)) rabbits will be optically mapped (approximately 1 month later) to obtain ..
  54. Testing Direct Effects of Reproduction on Stress and Mortality via Ovariectomy
    John D Hatle; Fiscal Year: 2010
    ..Last but not least, this grant will have a profound effect on the research environment in biology at the University of North Florida, by increasing the quality and quantity of opportunites for student research in biomedical science. ..
  55. CAV-1, Stat5a Signaling, and Estrogen-Dependent Breast Cancer
    Philippe G Frank; Fiscal Year: 2012
    ..The role of estrogen will be assessed by ovariectomy and supplementation with estrogen pellets. Tamoxifen-resistance will also be investigated...
  56. Temporomandibular joint syndrome in females
    Nancy Berman; Fiscal Year: 2005
    ..phenotype of trigeminal neurons by acting upon estrogen receptors during the natural estrous cycle, following ovariectomy and during pregnancy...
  57. PRETRANSLATIONAL REGULATION OF FSH AND LH
    Margaret Wierman; Fiscal Year: 1993
    ..of steroid administration (subphysiologic to supraphysiologic), (c) the impact of the time interval following ovariectomy before replacement, and (d) the duration of steroid replacement of FSH(beta), LH(beta), and alpha subunit mRNA ..
  58. MECHANISMS GOVERNING ONSET OF OVARIAN FUNCTION
    Kathleen Ryan; Fiscal Year: 1990
    ..b>Ovariectomy, followed by timed replacement of prepubertal levels of estradiol will reveal whether the ovarian steroid ..
  59. Transgenic Models of Estrogen Receptor Activity in Bone
    Joseph Alexander; Fiscal Year: 2004
    ..In an effort to shed light on ERalpha and ERbeta function in bone, re report implementation of a mouse model of ovariectomy (OVX)-induced OP as a system for further elucidating the molecular mechanisms in hormone-dependent bone ..
  60. Neuroprotective Effects of Estrogen in Serotonin Neurons
    Jessica Henderson; Fiscal Year: 2007
    ..The objective of the proposed research is to determine the effects of estrogen administration after ovariectomy on the kynurenine pathway...
  61. MODEL FOR PELVIC FLOOR DISORDERS
    Amanda Clark; Fiscal Year: 2004
    ..The specific aims will evaluate: 1) hormone replacement immediately after ovariectomy, 2) hormonal replacement after long term estrogen deprivation, 3) the rate of matrix metalloproteinase up-..
  62. A Novel Therapeutic Agent for Postmenopausal Bone Loss
    MERVYN WEITZMANN; Fiscal Year: 2005
    ..We have recently reported that inhibiting the elevated levels of IL-7 induced by ovariectomy (ovx) in mice using a neutralizing antibody, is efficacious in preventing ovx-induced bone loss in mice in vivo...
  63. Cocaine Abuse and the Role of Gonadal Steroid Hormones
    NANCY MELLO; Fiscal Year: 2005
    ..will be studied in an own-control design across gonadal steroid treatment conditions, and before and after ovariectomy and castration...
  64. Mechanism of Estrogen's Inhibitory Effects on Feeding
    LISA ECKEL; Fiscal Year: 2004
    ..The importance of the rat's ovarian cycle in the control of food intake is revealed by ovariectomy, which increases food intake, decreases sensitivity to CCK, promotes body weight gain and, in the absence of ..
  65. Estrogen Effects on Atrophic Skeletal Muscle
    Marybeth Brown; Fiscal Year: 2009
    ..Prior studies in animals have demonstrated that a lack of circulating E2 (subsequent to ovariectomy (OVX)) impairs recovery of laboratory-induced atrophic skeletal muscle...