Genomes and Genes
Summary: Surgical removal of the pancreas. (Dorland, 28th ed)
Publications354 found, 100 shown here
- Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiationYuval Dor
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nature 429:41-6. 2004..rather than pluripotent stem cells, are the major source of new beta-cells during adult life and after pancreatectomy in mice...
- Systematic review and meta-analysis of technique for closure of the pancreatic remnant after distal pancreatectomyH P Knaebel
Department of General, Visceral and Trauma Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
Br J Surg 92:539-46. 2005Appropriate closure of the pancreatic remnant after distal pancreatectomy is still debated. A variety of procedures have been recommended to reduce the frequency of pancreatic fistula...
- Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definitionMoritz N Wente
Department of General Surgery, University of Heidelberg, Heidelberg, Germany
Surgery 142:20-5. 2007..Because of these variations in the definition of what constitutes a PPH, the incidences of its occurrence are not comparable...
- Distal pancreatectomy: risk factors for surgical failure in 302 consecutive casesJorg Kleeff
Department of General Surgery, University of Heidelberg, Heidelberg, Germany
Ann Surg 245:573-82. 2007The objective of this study was to identify potential risk factors for mortality and morbidity after distal pancreatectomy, with special focus on the formation of pancreatic fistula.
- Laparoscopic vs open distal pancreatectomy for solid pseudopapillary tumor of the pancreasRen Chao Zhang
Ren Chao Zhang, Jia Fei Yan, Xiao Wu Xu, Ke Chen, Harsha Ajoodhea, Yi Ping Mou, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
World J Gastroenterol 19:6272-7. 2013To compare short- and long-term outcomes of laparoscopic vs open distal pancreatectomy for solid pseudopapillary tumor (SPT) of the pancreas.
- Distal pancreatectomy: does the method of closure influence fistula formation?Maureen K Sheehan
Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA
Am Surg 68:264-7; discussion 267-8. 2002The appropriate closure of the pancreatic remnant after distal pancreatectomy is still debated. Suture techniques, stapled closure, and pancreaticoenteric anastomosis all have their supporters...
- Robotic distal pancreatectomy: cost effective?Joshua A Waters
Department of Surgery, Indiana University, Indianapolis, IN 46202, USA
Surgery 148:814-23. 2010..This study compares the costs and the outcomes of open, laparoscopic, and robotic distal pancreatectomies. We hypothesized that robotic distal pancreatectomy is cost-effective.
- Islet autotransplant outcomes after total pancreatectomy: a contrast to islet allograft outcomesDavid E R Sutherland
Department of Surgery, Division of Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Transplantation 86:1799-802. 2008..In contrast, as shown here, islet autotransplants (IATs) show durable function and extended insulin-independence rates, despite a lower beta-cell mass...
- Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trialMarkus K Diener
Study Centre of the German Surgical Society and Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
Lancet 377:1514-22. 2011The ideal closure technique of the pancreas after distal pancreatectomy is unknown...
- Glucose metabolism in 105 children and adolescents after pancreatectomy for congenital hyperinsulinismJacques Beltrand
Pediatric Endocrinology and Diabetes, Hopital Necker Enfants Malades, Université Paris Descartes Sorbonne Paris Cité, Paris, France
Diabetes Care 35:198-203. 2012To describe the long-term metabolic outcome of children with congenital hyperinsulinism after near-total or partial elective pancreatectomy.
- Laparoscopic resection of exocrine carcinoma in central and distal pancreas results in a high rate of radical resections and long postoperative survivalIrina Pavlik Marangos
Interventional Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Surgery 151:717-23. 2012..The objective of the present study was to investigate this question with the rate of R0 resection and long-term survival as endpoints...
- Novel method of stump closure for distal pancreatectomy with a 75% reduction in pancreatic fistula rateJoseph A Blansfield
Geisinger Medical Center, Section of Surgical Oncology, 100 N Academy Avenue, MC 21 69, Danville, PA, USA
J Gastrointest Surg 16:524-8. 2012Pancreatic fistula is a significant problem for patients undergoing distal pancreatectomy with fistula rates up to 61%. Fistulas lead to substantial morbidity...
- Solid-pseudopapillary tumor of the pancreas: CT and MRI features of 3 casesDan Jun Dong
Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
Hepatobiliary Pancreat Dis Int 5:300-4. 2006..Solid-pseudopapillary tumor of the pancreas is a rather rare but low-grade malignant tumor with good prognosis after surgical excision...
- Decrease in clinically relevant pancreatic fistula by coverage of the pancreatic remnant after distal pancreatectomyMatthias Hassenpflug
Department of General Surgery, University of Heidelberg, Heidelberg, Germany
Surgery 152:S164-71. 2012Pancreatic fistulas after distal pancreatectomy occur in up to 60% of patients with distal pancreatectomy...
- Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection?Alessandro Zerbi
Pancreas Unit, Department of Surgery, S Raffaele Scientific Institute, V Olgettina 60, 20132, Milan, Italy
Ann Surg Oncol 15:1161-8. 2008..Pancreas is a possible site of metastases from renal cell carcinoma (RCC). The aim of this study was to define the role of surgery in their treatment...
- Can preoperative CA19-9 and CEA levels predict the resectability of patients with pancreatic adenocarcinoma?Young Choon Kim
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, Korea
J Gastroenterol Hepatol 24:1869-75. 2009..We aimed to explore the predictive ability of preoperative carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) levels for assessing tumor resectability (R0 resection) in patients with pancreatic adenocarcinoma...
- Distal pancreatectomy with preservation of the spleenAndrew L Warshaw
Department of Surgery, Massachusetts General Hospital, 55 Fruit St, WHT506, Boston, MA 02114 2696, USA
J Hepatobiliary Pancreat Sci 17:808-12. 2010Distal pancreatectomy (resection of the pancreatic body and tail) can be performed with or without preservation of the spleen...
- A surgical and pathological based classification of resective treatment of pancreatic cancer. Summary of an international workshop on surgical procedures in pancreatic cancerS Pedrazzoli
Dipartimento di Scienze Mediche e Chirurgiche, Semeiotica Chirurgica, University of Padova, Italy
Dig Surg 16:337-45. 1999The extent of pancreatic resection and lymphadenectomy, both for Kausch-Whipple pancreatoduodenectomy and for left pancreatectomy, is variable between surgeons, according to their training.
- Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional casesLaura H Tang
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Am J Surg Pathol 29:512-9. 2005..The possibility that these tumors represent high-grade malignant transformation of a conventional low-grade SPT is proposed...
- Conventional laparoscopic and robot-assisted spleen-preserving pancreatectomy: does da Vinci have clinical advantages?Chang Moo Kang
Division of Biliopancreas, Department of Surgery, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, Korea
Surg Endosc 25:2004-9. 2011Function-preserving minimally invasive pancreatectomy is thought to be an ideal approach for pancreatic benign and borderline malignant lesions requiring pancreatectomy...
- Prognostic score predicting survival after resection of pancreatic neuroendocrine tumors: analysis of 3851 patientsKarl Y Bilimoria
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Ann Surg 247:490-500. 2008..The objective of this study was to identify factors predicting survival after pancreatectomy for PNETs and to establish a postresection prognostic score.
- A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patientsPeter J Allen
Memorial Sloan Kettering Cancer Center, USA
Ann Surg 244:572-82. 2006..To define a group of patients with pancreatic cysts who do not require resection...
- Pancreatic resection of isolated metastases from nonpancreatic primary cancersSushanth Reddy
Department of Surgery, The Johns Hopkins University, 600 North Wolfe Street, Carnegie 681, Baltimore, Maryland 21287, USA
Ann Surg Oncol 15:3199-206. 2008..The goal of this study is to report the safety and efficacy of pancreatic resection for isolated metastatic cancers from nonpancreatic primary disease...
- The surgical management of congenital hyperinsulinemic hypoglycemia in infancyC Nihoul Fékété
Department of Pediatric Surgery, Hopital des Enfants Malades, Paris, France
J Pediatr Surg 39:267-9. 2004..it leads to complete recovery without diabetes; on the contrary, diffuse CHI can only be cured by near-total pancreatectomy, and medical treatment, if efficient, is preferable...
- Influence of resection margins and treatment on survival in patients with pancreatic cancer: meta-analysis of randomized controlled trialsGiovanni Butturini
Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, 5th Floor, UCD Bldg, Daulby St, Liverpool L69 3GA, England
Arch Surg 143:75-83; discussion 83. 2008..To assess the influence of resection margins and adjuvant chemoradiotherapy or chemotherapy on survival for patients with pancreatic cancer by meta-analysis of individual data from randomized controlled trials...
- Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinomaK Motojima
Second Department of Surgery, Nagasaki University School of Medicine, Japan
Ann Surg 217:138-43. 1993..These results imply that total pancreatectomy for eliminating tumor recurrence due to multicentricity may not be warranted.
- Pancreatic resection for M1 pancreatic ductal adenocarcinomaShailesh V Shrikhande
Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai, 400012, India
Ann Surg Oncol 14:118-27. 2007..Improved safety of pancreatic surgery has led to consideration of more aggressive approaches, such as resection for primary pancreatic ductal adenocarcinoma (PDAC) with metastatic disease (M1)...
- National failure to operate on early stage pancreatic cancerKarl Y Bilimoria
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Ann Surg 246:173-80. 2007..Our objective was to evaluate utilization of surgery in early stage disease and identify factors predicting failure to undergo surgery...
- Renal cell carcinoma metastatic to the pancreas: results of surgical managementT A Sohn
Department of Surgery, The Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Baltimore, MD 21287
J Gastrointest Surg 5:346-51. 2001..Of those, six underwent pancreaticoduodenectomy and two underwent distal pancreatectomy, whereas the two remaining patients underwent total pancreatectomy for extensive tumor involvement throughout ..
- Middle pancreatectomy: safety and long-term resultsToshio Shikano
Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
Surgery 147:21-9. 2010Pancreaticoduodenectomy and distal pancreatectomy for lesions of the neck or body of the pancreas sacrifice a large amount of normal pancreatic tissue...
- Vascular resection and reconstruction for pancreatic malignancy: a single center survival studyMohammad Al-Haddad
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
J Gastrointest Surg 11:1168-74. 2007..Recently, several centers have introduced portal and superior mesenteric vein resection and reconstruction during extended pancreatectomy, rendering the previously inoperable cases resectable.
- Totally laparoscopic Roux-en-Y duct-to-mucosa pancreaticojejunostomy after middle pancreatectomy: a consecutive nine-case series at a single institutionFernando Rotellar
Departments of General and Abdominal Surgery, University Clinic of Navarre, University of Navarre, Pamplona, Spain
Ann Surg 247:938-44. 2008..To present the results of a series of laparoscopic middle pancreatectomies with roux-en-Y duct-to-mucosa pancreaticojejunostomy...
- Robotic spleen-preserving distal pancreatectomy. A case reportC Vasilescu
Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania
Acta Chir Belg 109:396-9. 2009Distal pancreatectomy (DP) is the removal of the pancreatic tissue at the left side of the superior mesenteric vein and it is traditionally approached by an open or laparoscopic exposure...
- A multicenter analysis of distal pancreatectomy for adenocarcinoma: is laparoscopic resection appropriate?David A Kooby
Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
J Am Coll Surg 210:779-85, 786-7. 2010As compared with open distal pancreatectomy (ODP), laparoscopic distal pancreatectomy (LDP) affords improved perioperative outcomes. The role of LDP for patients with pancreatic ductal adenocarcinoma (PDAC) is not defined.
- Early versus late drain removal after standard pancreatic resections: results of a prospective randomized trialClaudio Bassi
Department of Surgery, G B Rossi Hospital, University of Verona, Verona, Italy
Ann Surg 252:207-14. 2010..The role of surgically placed intra-abdominal drainages after pancreatic resections has not been clearly established. In particular, their effect on morbidity rates and the optimal timing for their removal remains controversial...
- Risk factors for pancreatic leak after distal pancreatectomyHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann Surg 250:277-81. 2009..We sought to evaluate the incidence of and identify risk factors for the development of PL in patients undergoing distal pancreatectomy (DP) at a single high-volume institution.
- Prognostic factors for survival after extended pancreatectomy for pancreatic head cancer: influence of resection margin status on survivalKoichi Kato
Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
Pancreas 38:605-12. 2009..The aim of this study was to examine the influence of resection margin status on survival after extended radical resection for pancreatic head cancer...
- Implications and cost of pancreatic leak following distal pancreatic resectionJ Ruben Rodriguez
Center for Clinical Effectiveness in Surgery, Harvard Medical School, Boston, USA
Arch Surg 141:361-5; discussion 366. 2006..We sought to provide an economic framework for potential interventions aimed at reducing its occurrence...
- Laparoscopic distal pancreatectomy and open distal pancreatectomy: a nonrandomized comparative studyToshifumi Matsumoto
Department of Surgery I, Oita University Faculty of Medicine, Oita, Japan
Surg Laparosc Endosc Percutan Tech 18:340-3. 2008Although laparoscopic distal pancreatectomy (LDP) is technically feasible, its benefits remain uncertain. The purpose of this study was to compare the clinical results of LDP and open distal pancreatectomy (ODP)...
- Laparoscopic central pancreatectomy: single institution experience of 6 patientsAntonio Sa Cunha
Department of Digestive Surgery, Haut Leveque Hospital, CHU Bordeaux, Bordeaux, France
Surgery 142:405-9. 2007Medial pancreatectomy is an alternative technique for benign or low-grade malignant tumors of the neck of the pancreas. We describe our experience of laparoscopic central pancreatectomy.
- Curative laparoscopic resection for pancreatic neoplasms: a critical analysis from a single institutionLaureano Fernandez-Cruz
Surgical Department, ICMD Hospital Clínic de Barcelona, Villarroel, 170, 08036 Barcelona, Spain
J Gastrointest Surg 11:1607-21; discussion 1621-2. 2007..6%). Laparoscopic spleen-preserving distal pancreatectomy (Lap SPDP) was performed in 52 patients (63...
- Intramuscular autotransplantation of pancreatic islets in a 7-year-old child: a 2-year follow-upE Rafael
Department of Surgery, Karolinska Institutet, Karolinska University Hospital in Huddinge, Stockholm, Sweden
Am J Transplant 8:458-62. 2008A 7-year-old girl with severe hereditary pancreatitis underwent total pancreatectomy. A total of 160,000 islet equivalents (6400 islet/kg) were transplanted to the brachioradialis muscle of the right forearm...
- Peri-operative mortality and long-term survival after total pancreatectomy for pancreatic adenocarcinoma: a population-based perspectiveHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Surg Oncol 99:87-92. 2009Many surgeons perceive total pancreatectomy (TP) for pancreatic adenocarcinoma to be associated with inferior outcomes compared to partial pancreatectomy (PP), such as pancreaticoduodenectomy (PD) and distal pancreatectomy (DP)...
- A single-institution prospective study of laparoscopic pancreatic resectionAntonio Sa Cunha
Department of Digestive Surgery, Centre Hospitalier Universitaire de Bordeaux, Avenue de Magellan, Pessac 33604, France
Arch Surg 143:289-95; discussion 295. 2008..Laparoscopic pancreatic resection can safely duplicate all of the open pancreatic procedures...
- Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential marginsSteven M Strasberg
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Am Coll Surg 204:244-9. 2007..We now present results of treatment of patients with adenocarcinoma using RAMPS with particular reference to the ability of this procedure to obtain negative tangential margin rates...
- Laparoscopic distal pancreatectomy is as safe and feasible as open procedure: a meta-analysisKun Xie
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
World J Gastroenterol 18:1959-67. 2012To evaluate the feasibility and safety of laparoscopic distal pancreatectomy (LDP) compared with open distal pancreatectomy (ODP).
- β-Cell replication and islet neogenesis following partial pancreatectomySeung Hee Lee
Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
Islets 3:188-95. 2011Partial pancreatectomy is one of the most commonly used models in the study of β-cell regeneration...
- [Distal pancreatic resection--indications, techniques and complications]U Adam
Zentralbl Chir 126:908-12. 2001..METHODS: We analyzed the prospectively documented perioperative data of 41 patients undergoing distal pancreatectomy between 1994 and 2001...
- Robotic left pancreatectomy for pancreatic solid pseudopapillary tumorDimitrios Ntourakis
Pôle des Pathologies Digestives, Hépatiques et de la Transplantation, Hôpital de Hautepierre Hôpitaux Universitaires de Strasbourg, Universite de Strasbourg, Strasbourg, France
Ann Surg Oncol 18:642-3. 2011..1,2 Its resection could be performed by robotic technique with respect to oncological principles to avoid tumor cell dissemination.3..
- Robotic versus open pancreatectomy: a systematic review and meta-analysisJie Zhang
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Ann Surg Oncol 20:1774-80. 2013..The objective of this meta-analysis is to compare the clinical and oncologic safety and efficacy of robotic versus open pancreatectomy.
- A noninvasive mucinous cystic neoplasm with intermediate-grade dysplasia of the pancreas and extensive squamous metaplasia: a case report with clinicopathological correlationPeifeng Li
Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi an, Shaanxi, 710032, People s Republic of China
Diagn Pathol 7:89. 2012..The patient underwent cystojejunostomy, laparotomy and distal pancreatectomy consecutively because of the initial diagnosis of "pancreatic cyst"...
- Long-term results of resection of adenocarcinoma of the body and tail of the pancreas using radical antegrade modular pancreatosplenectomy procedureJonathan B Mitchem
Section of Hepato Pancreato Biliary Surgery, Washington University in St Louis, St Louis, MO 63110, USA
J Am Coll Surg 214:46-52. 2012..The purpose of this report is to provide long-term survival results...
- Robot-assisted minimally invasive distal pancreatectomy is superior to the laparoscopic techniqueMustapha Daouadi
Division of GI Surgical Oncology, General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
Ann Surg 257:128-32. 2013Laparoscopic distal pancreatectomy (LDP) reduces postoperative morbidity, hospital stay, and recovery as compared with open distal pancreatectomy...
- Is it worthwhile to preserve adult spleen in laparoscopic distal pancreatectomy? Perioperative and patient-reported outcome analysisSung Hoon Choi
Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, Ludlow Faculty Research Building 204, 50 Yonsei ro, Seodaemun gu, Seoul, 120 752, Korea
Surg Endosc 26:3149-56. 2012Despite the emphasis on its role, the spleen has commonly been removed in distal pancreatectomy. We designed this study to evaluate the efficacy of spleen salvage during laparoscopic distal pancreatectomy for patients with benign and ..
- Efficacy of an absorbable fibrin sealant patch (TachoSil) after distal pancreatectomy: a multicenter, randomized, controlled trialMarco Montorsi
Department of General Surgery, University of Milan, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy
Ann Surg 256:853-9; discussion 859-60. 2012To evaluate the role of an absorbable fibrin sealant patch (TachoSil) in reducing postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).
- Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entityT A Sohn
Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-4606, USA
Ann Surg 234:313-21; discussion 321-2. 2001..pancreas or diffusely involved the gland, with 70% being resected via pancreaticoduodenectomy, 22% via total pancreatectomy, and 8% via distal pancreatectomy...
- Management of remnant pancreatic stump fto prevent the development of postoperative pancreatic fistulas after distal pancreatectomy: current evidence and our strategyIsamu Makino
Department of Gastroenterologic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
Surg Today 43:595-602. 2013Distal pancreatectomy (DP) is the most common surgical procedure for treating benign and malignant lesions in the body or tail of the pancreas...
- Current status of robot-assisted laparoscopic pancreaticoduodenectomy and distal pancreatectomy: a comprehensive reviewEric C H Lai
Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China
Asian J Endosc Surg 6:158-64. 2013This article reviews the current status of robot-assisted laparoscopic pancreaticoduodenectomy and distal pancreatectomy.
- High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinomaC Bassi
Pancreatic Unit, Department of Surgical and Gastroenterological Sciences, Policlinico B Roma, Verona University, Verona, Italy
Br J Surg 90:555-9. 2003..Pancreatic metastases from renal cell carcinoma are rare but highly resectable. The aim of this study was to review a series of patients with this condition...
- Incidental intraoperative discovery of a pancreatic neuroendocrine tumor associated with chronic pancreatitisValeriu Surlin
Department of Surgery, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200393 Craiova, Romania
Diagn Pathol 7:132. 2012..The tumor of 1.5 cm size was well differentiated and confined to the pancreas, and was resected by a distal splenopancreatectomy...
- Robot-assisted spleen-preserving distal pancreatectomy: a single surgeon's experiences and proposal of clinical applicationHo Kyoung Hwang
Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul 120 752, South Korea
Surg Endosc 27:774-81. 2013..laparoscopic techniques are usually required for safe and successful laparoscopic spleen-preserving distal pancreatectomy. The unique characteristics of robotic surgical system are thought to be useful for this minimally invasive ..
- Enucleation in pancreatic surgery: indications, technique, and outcome compared to standard pancreatic resectionsThilo Hackert
Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
Langenbecks Arch Surg 396:1197-203. 2011..The aim of the study was to evaluate the indications, technique, and outcome of this limited local approach compared to major resections...
- Laparoscopic distal pancreatectomy: evolution of a technique at a single institutionShiva Jayaraman
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Am Coll Surg 211:503-9. 2010..The pancreas remains an organ for which routine laparoscopic resection is uncommon...
- Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patientsFeng Yang
Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Am J Surg 198:210-5. 2009..The aim of this study is to describe the clinicopathologic features and surgical management of this disease in our institution...
- Perioperative and long-term results after left pancreatectomy: a single-institution, non-randomized, comparative study between open and laparoscopic approachGiovanni Butturini
Department of Surgery, G B Rossi Hospital, University of Verona, P le L A Scuro 10, 37134 Verona, Italy
Surg Endosc 25:2871-8. 2011..In this study, we provide a nonrandomized comparison between laparoscopic and open left pancreatectomy (OLP) for benign and borderline tumors, focusing on both perioperative and long-term results.
- A simple and safe anastomosis in pancreaticogastrostomy using mattress suturesHiroaki Ohigashi
Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
Am J Surg 196:130-4. 2008..Postoperative amylase levels in the drainage fluid decreased significantly and none of the 17 patients developed pancreatic fistula formation. The technique is simple and shortens the time required for anastomosis...
- Blind distal pancreatectomy for occult insulinoma, an inadvisable procedureBoaz Hirshberg
Division of Intramural Research, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
J Am Coll Surg 194:761-4. 2002..Blind distal pancreatectomy has been advocated for occult insulinomas not detected on imaging studies or during abdominal exploration...
- Parenchyma-preserving resections for small nonfunctioning pancreatic endocrine tumorsMassimo Falconi
Chirurgia Generale B Pancreas Unit, Department of Surgery, University of Verona, Policlinico GB Rossi, Verona, Italy
Ann Surg Oncol 17:1621-7. 2010Parenchyma-preserving resections (PPRs), including enucleation and middle pancreatectomy (MP), are accepted procedures for insulinomas, but their role in the treatment of nonfunctioning pancreatic endocrine tumors (NF-PETs) is debated...
- Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patientsMarcel C C Machado
Department of Gastroenterology, University of Sao Paulo, Sao Paulo, Brazil
Surgery 143:29-34. 2008..Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential. This study examines clinical differences and prognosis between male and female patients...
- Postoperative pancreatic fistulas are not equivalent after proximal, distal, and central pancreatectomyWande Pratt
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Gastrointest Surg 10:1264-78; discussion 1278-9. 2006..and grade A patients were identical across resection types, though grade A fistula was more common in distal pancreatectomy. For each resection type, length of stay and costs progressively increased with grades B and C...
- Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survivalChandrajit P Raut
Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Ann Surg Oncol 13:582-94. 2006..This study evaluated the outcome after pancreatectomy for IPMN according to the pancreatic transection margin status and the presence or absence of invasive ..
- Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomyKeiko Y Hayashi
Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
Arch Histol Cytol 66:163-74. 2003..and differentiation dynamics of pancreatic endocrine cells in the rat pancreas 1 to 28 days after a 90% pancreatectomy. Regeneration of endocrine cells started immediately after pancreatectomy...
- Laparoscopic distal pancreatectomy: a comparative studyC N Tang
Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
Hepatogastroenterology 54:265-71. 2007This article aims to describe the different techniques of laparoscopic distal pancreatectomy and to compare the results of our series of 9 laparoscopic resections against the historical open control in the same institution...
- Systematic review of minimally invasive pancreatic resectionChristopher D Briggs
Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Bio centre, University of Leicester, University Road, Leicester LE1 7RH, UK
J Gastrointest Surg 13:1129-37. 2009..This article reviews the current published literature on the safety and efficacy of minimally invasive surgery of the pancreas...
- National complication rates after pancreatectomy: beyond mere mortalityJessica P Simons
Department of Surgery, UMass Surgical Outcomes Analysis and Research, University of Massachusetts Medical School, 55 Lake Avenue North, Suite S3 752, Worcester, MA 01655, USA
J Gastrointest Surg 13:1798-805. 2009..National studies on in-hospital pancreatic outcomes have focused on mortality. Non-fatal morbidity affects a greater proportion of patients...
- Intraductal papillary mucinous neoplasms of the pancreas: an updated experienceTaylor A Sohn
Departments of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Ann Surg 239:788-97; discussion 797-9. 2004..To update the authors' experience with intraductal papillary mucinous neoplasms (IPMNs) of the pancreas...
- Clinical value of serum CA19-9 levels in evaluating resectability of pancreatic carcinomaShun Zhang
Department of Hepatobiliary Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China
World J Gastroenterol 14:3750-3. 2008..To evaluate the clinical value of serum CA19-9 levels in predicting the respectability of pancreatic carcinoma according to receiver operating characteristic (ROC) curve analysis...
- Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional seriesSushanth Reddy
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Am Coll Surg 208:950-7; discussion 957-9. 2009..Solid-pseudopapillary neoplasms (SPNs) are rare pancreatic tumors with malignant potential. Clinicopathologic characteristics and outcomes of patients with SPN were reviewed...
- Outcome after pancreatectomy and islet autotransplantation in a pediatric populationMelena D Bellin
Department of Pediatrics, Division of Endocrinology, University of Minnesota, 516 Delaware St SE, Minneapolis, MN 55455, USA
J Pediatr Gastroenterol Nutr 47:37-44. 2008Little is known regarding outcomes after pancreatectomy and islet autotransplantation for chronic pancreatitis in pediatric patients...
- Significance of splenic vein thrombosis in chronic pancreatitisAnil K Agarwal
Department of Gastrointestinal Surgery, Gobind Ballabh Pant Hospital and Maulana Azad Medical College, New Delhi 110002, India
Am J Surg 196:149-54. 2008..Splenic vein thrombosis leading to sinistral portal hypertension and variceal bleeding is a complication of chronic pancreatitis. The management of these patients without variceal bleeding remains controversial...
- Tumor-node-metastasis staging of pancreatic adenocarcinomaMatthew H G Katz
Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
CA Cancer J Clin 58:111-25. 2008....
- Surgical treatment of pancreatic serous cystadenoma: aggressive for operations but limited resectionsJi Shiang Hung
Department of Surgery, National Taiwan University Hospital Yunlin Branch, Yunlin County, Taiwan, Republic of China
Pancreas 35:358-60. 2007..Serous cystadenomas of the pancreas are being increasingly identified as the advancement of the diagnostic abdominal imaging. However, the optimal timing of surgical intervention for this disease remains controversial...
- The effect of age on short-term outcomes after pancreatic resection: a population-based studyTaylor S Riall
Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0542, USA
Ann Surg 248:459-67. 2008..To use a large population-based cohort to determine age-dependent short-term outcomes after pancreatic resection...
- Metaanalysis of trials comparing minimally invasive and open distal pancreatectomiesGiuseppe R Nigri
Department of Surgery, St Andrea Hospital, Sapienza University of Rome, 5 Ovest, Via di Grottarossa 1035, 00189, Rome, Italy
Surg Endosc 25:1642-51. 2011The current literature suggests that minimally invasive distal pancreatectomy (MIDP) is associated with faster recovery and less morbidity than open surgery...
- Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemiaF Menni
, , Centre Hospitalier Universitaire Necker-Enfants Malades, Paris, France
Pediatrics 107:476-9. 2001..Thirty-six patients had infancy-onset hyperinsulinism, of whom 19 were treated medically and 17 underwent pancreatectomy (10 patients for a focal adenomatous hyperplasia and 7 for diffuse hyperinsulinism)...
- Single-center experience of laparoscopic left pancreatic resection in 359 consecutive patients: changing the surgical paradigm of left pancreatic resectionKi Byung Song
Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Songpa Ku, Seoul, South Korea
Surg Endosc 25:3364-72. 2011Laparoscopic distal pancreatectomy (LDP) is increasingly performed for lesions of the body and tail of the pancreas...
- Multiple proinsulin-secreting tumors of the pancreas treated by laparoscopic distal pancreatectomy and splenectomyGary Clark
Department of Surgery, Kaiser Permanente, Richmond, CA, USA
World J Surg 33:397-9. 2009..Laboratory testing can frequently result in data challenging to the clinician to confirm the biochemical diagnosis. Proinsulin, in addition to insulin levels, may be essential in evaluating and diagnosing an insulinoma...
- Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancerAndrew V Biankin
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
Gastroenterology 137:558-68, 568.e1-11. 2009Current methods of preoperative staging and predicting outcome following pancreatectomy for pancreatic cancer (PC) are inadequate...
- Pancreatic leak after left pancreatectomy is reduced following main pancreatic duct ligationM M Bilimoria
Department of Surgical Oncology, Box 444, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 4009, USA
Br J Surg 90:190-6. 2003Although much is known about the long-term outcome of patients undergoing left (distal) pancreatectomy for malignancy, comparatively little is known about the optimal management strategy for the residual transected pancreatic parenchyma ..
- Laparoscopic left pancreatectomy: complication risk score correlates with morbidity and risk for pancreatic fistulaSharon M Weber
Section of Surgical Oncology, Department of Surgery, H4 752 Clinical Science Center, University of Wisconsin Hospital, Madison, WI, USA
Ann Surg Oncol 16:2825-33. 2009Surgeons are performing laparoscopic left pancreatectomy (LLP) with increasing frequency; however, determinants of perioperative outcome after LLP are not well defined. We evaluated factors contributing to morbidity after LLP.
- Surgery insight: surgical management of pancreatic cancerChristoph W Michalski
Department of Surgery, University of Heidelberg, Heidelberg, Germany
Nat Clin Pract Oncol 4:526-35. 2007..This Review describes the current status of surgical treatment for pancreatic ductal adenocarcinoma, and highlights the new developments in this field...
- Solid pseudopapillary neoplasms of the pancreas: an updated experienceBrian K P Goh
Department of Surgery, Singapore General Hospital, Singapore
J Surg Oncol 95:640-4. 2007..The aim of this study is to report an update of the surgical experience at a single institution with these unusual tumors...
- Necrotizing pancreatitis: contemporary analysis of 99 consecutive casesS W Ashley
Department of Surgery, Brigham and Women s Hospital Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Ann Surg 234:572-9; discussion 579-80. 2001..To analyze the impact of a conservative strategy of management in patients with necrotizing pancreatitis, reserving intervention for patients with documented infection or the late complications of organized necrosis...
- Outcome of paraaortic node-positive pancreatic head and bile duct adenocarcinomaTakanori Yoshida
Department of Surgery I, Oita University Faculty of Medicine, Oita, Japan
Am J Surg 187:736-40. 2004..This retrospective study aimed to identify the clinicopathologic features and surgical results of paraaortic node-positive periampullary adenocarcinoma...
- The role of total pancreatectomy and islet autotransplantation for chronic pancreatitisJuan J Blondet
Division of Surgical Critical Care Trauma, Department of Surgery, University of Minnesota, MMC 11, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
Surg Clin North Am 87:1477-501, x. 2007Total pancreatectomy and islet autotransplantation are done for chronic pancreatitis with intractable pain when other treatment measures have failed, allowing insulin secretory capacity to be preserved, minimizing or preventing diabetes, ..
- Treatment guidelines for branch duct type intraductal papillary mucinous neoplasms of the pancreas: when can we operate or observe?Jin Young Jang
Department of Surgery, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, South Korea
Ann Surg Oncol 15:199-205. 2008..However, no definite treatment guideline (with respect to surgery or observation) has been issued on the management of branch duct type IPMN...
- Single-centre experience of laparoscopic pancreatic surgeryB I Røsok
Division of Surgery, Section for Gastrointestinal Surgery, Oslo University Hospital OUH, Rikshospitalet, 0027 Oslo, Norway
Br J Surg 97:902-9. 2010..Laparoscopic resection is regarded as safe and feasible in selected patients with benign pancreatic tumours. Few data exist on laparoscopic surgery for malignant lesions and larger neoplasms in unselected patients...
- Surgical versus non-surgical treatment of congenital hyperinsulinismKineret Mazor-Aronovitch
Pediatric Endocrinology Unit, Edmond Safra Pediatric Medical Center, Tel Hashomer, Israel
Pediatr Endocrinol Rev 6:424-30. 2009..In its diffuse severe form, it is traditionally treated with over 95% pancreatectomy. However, even after this procedure normoglycemia is not always achieved...
- Total pancreatectomy with and without islet cell transplantation for chronic pancreatitis: a series of 85 consecutive patientsGiuseppe Garcea
Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, United Kingdom
Pancreas 38:1-7. 2009This study examined 85 consecutive patients undergoing total pancreatectomy (+/-islet cell transplant), examining pain relief, insulin requirements, and glycemic control postoperatively.
- Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for surgical treatment of chronic pancreatitis: a systematic review and meta-analysisMarkus K Diener
Department of General, Visceral and Trauma Surgery, University of Heidelberg, Heidelberg, Germany
Ann Surg 247:950-61. 2008....
- The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trialMicheal G Sarr
Gastroenterology Research Unit AL 2 436, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
J Am Coll Surg 196:556-64; discussion 564-5; author reply 565. 2003b>Pancreatectomy can be complicated by pancreatic anastomotic leakage, causing major morbidity.
- Beta Cell Adaptation to Stress in Baboon Pancreas After Partial PancreatectomyFRANCO BATTISTA FOLLI; Fiscal Year: 2010..IR) baboons;(2) to examine the effects of an acute increase in insulin secretory demand (achieved by partial pancreatectomy, PPx) on [unreadable]-cell function, morphology and ultrastructure (with particular emphasis on IAPP and A[..
- Beta-cell Compensation in Partial Pancreatectomy MiceJOHN L LEAHY; Fiscal Year: 2013..such as occurs in evolving type 1 diabetes, likely also type 2 diabetes, using the experimental model of 60% pancreatectomy (Px) in normally insulin sensitive rodents...
- Intervention of Pancreatic Oncogenic Pathways with Dietary TocotrienolMokenge P Malafa; Fiscal Year: 2012..3) To perform a phase 1 a/b trial to investigate whether consumption of 4-tocotrienol for 2 weeks prior to pancreatectomy will induce p27 and alter Mek/Erk and PI3K/Akt signaling pathways leading to an inhibition of proliferation ..
- Novel Strategies to Increase Insulin Independence after Islet AutotransplantationHongjun Wang; Fiscal Year: 2013DESCRIPTION (provided by applicant): Total pancreatectomy with islet autotransplantation (TP-IAT) is currently being performed to treat intractable pain and to prevent "brittle" diabetes in well-selected patients with chronic pancreatitis...
- Islet and Mesenchymal Stem Cell Co-transplantation Prevents Onset of DiabetesHongjun Wang; Fiscal Year: 2013DESCRIPTION (provided by applicant): Total pancreatectomy and islet autotransplantation (TP-IAT) are currently being performed to treat intractable pain in selected patients with chronic pancreatitis (CP)...
- PANCREAS AND ISLET TRANSPLANTATION IN HUMANSRODERICK PAUL ROBERTSON; Fiscal Year: 2013..Our approach is to study intrahepatic islet function in patients with chronic pancreatitis who undergo total pancreatectomy and autoislet transplantation (TP/AIT) in both hepatic and nonhepatic sites...
- Islet Dysregulation in Infants with Congenital HyperinsulinismCHARLES ALFRED STANLEY; Fiscal Year: 2013..This includes one-third of diffuse HI cases that require pancreatectomy and half of cases that are responsive to medical treatment with diazoxide...
- Role of GLP-1 in Congenital HyperinsulinismDIVA DEL CARMEN DE LEON; Fiscal Year: 2010..Most patients are unresponsive to available medical therapy and require partial pancreatectomy to control the hypoglycemia, resulting in prolonged hospitalization, high risk for life-threatening ..
- Role of Neurogenic Inflammation in Pancreatic CancerBrian M Davis; Fiscal Year: 2013..The link between CP and PDAC is so strong that physicians often recommend prophylactic pancreatectomy for patients with severe CP. The mechanistic link between pancreatic inflammation and cancer is not known...
- Sitagliptin therapy to improve outcomes after islet autotransplantation.Melena D Bellin; Fiscal Year: 2013..a randomized double-blinded controlled trial evaluating the effect of sitagliptin treatment following total pancreatectomy and islet autotransplant on insulin independence and islet function...
- Cell Lineage and Homeostasis of Pancreatic Beta Cells in the AgedJAKE ALDEN KUSHNER; Fiscal Year: 2013..We will quantify beta-cell mass expansion of aged mice in response to regenerative stimuli, injury (partial pancreatectomy, pancreatic ductal ligation, streptozotocin mediated beta-cell loss) or diabetes therapies (exendin- 4, ..
- Characterizing the Role of Pancreatic Progenitors in RegenerationMichael Parsons; Fiscal Year: 2013..destroying the acinar tissue;iii) A surgical procedure to remove a large portion of the pancreas (partial pancreatectomy)...
- Phase 2A Study of Exendin for the Treatment of Congenital HyperinsulinismDIVA DEL CARMEN DE LEON; Fiscal Year: 2013..Children affected by the most common form of CHI are unresponsive to medical therapy and require a near-total pancreatectomy shortly after birth for intractable hypoglycemia...
- Fuel Metabolism and insulin secretion in KATP-hyperinsulinism human isletsChanghong Li; Fiscal Year: 2013..Children with KATPHI are usually unresponsive to medical therapy and require pancreatectomy to control the hypoglycemia and prevent permanent brain damage...
- Role of Pulsatile Insulin SecretionPETER CAWOOD BUTLER; Fiscal Year: 2012..In the proposed studies, we will first examine humans with an ~50% pancreatectomy and those with IFG/IGT compared to controls for pulsatile insulin secretion and insulin sensitivity...
- Antibody bead array technology for diagnosis of pre-invasive pancreatic cancerPeter Allen; Fiscal Year: 2012..high-risk lesions to be resected prior to the development of an essentially incurable disease, and enable patients with low-risk lesions to avoid operation and spare them the physical, emotional, and financial costs of pancreatectomy.
- Smad regulation of pancreatic islet formationGeorge K Gittes; Fiscal Year: 2012..inhibitory smad7, in the regeneration of new beta cells in the adult mouse pancreas in response to a partial pancreatectomy. It appears that most new beta cells form from previous beta cells, but little or nothing is know about ..
- Magnetic Flow Sorter for Pancreatic Islet IsolationPaul W Todd; Fiscal Year: 2013..of human pancreatic islets of Langerhans for therapeutic transplantation for the prevention of diabetes in pancreatectomy patients...
- Program Project,Restoration of Endocrine Pancreas Funct*JOEL HABENER; Fiscal Year: 2004..of beta-cells via transplantation of stem/progenitor cells in animal models of diabetes (rat partial pancreatectomy). Project 2: Modulation of pancreatic islets for transplantation (PI: Dr...
- Pancreatic Intra-Islet DuctsGeorge K Gittes; Fiscal Year: 2013..however, in a genetically altered mouse model in which [unreadable]-cells do not proliferate after partial pancreatectomy, we describe a fairly dramatic sprouting of new ductal structures from existing large ducts after partial ..
- A Novel Method to Isolate Islet CellsJERRY KNOBELOCH; Fiscal Year: 2007..In addition, auto-islet transplantation for persons undergoing pancreatectomy for chronic pancreatitis has been performed with increasing success...
- INSULIN AND PROTEIN SYNTHESIS AFTER RESISTANCE EXERCISEPETER FARRELL; Fiscal Year: 1999..and the ability of muscle to hypertrophy due to chronic exercise will be elucidated using 70 and 90% partial pancreatectomy of mature (250g) rats...
- Data and Statistical Coordinating Center (DSCC) for the Collaborative Islet TransDonald M Stablein; Fiscal Year: 2012..episodes in persons with Type 1 diabetes or lacking pancreatic islets for any reason including therapeutic pancreatectomy or any loss of islet cell function...
- ISLET-KIDNEY TRANSPLANTS FOR TREATMENT OF DIABETIC ESRDDavid Sachs; Fiscal Year: 2006..to reverse hyperglycemia in diabetic baboons; and 4) Develop non-invasive techniques for partial pancreatectomy, preparation of IK and IK removal for transplantation...
- Effects of brain-death on islet recovery and functional*John Thompson; Fiscal Year: 2006..end, islets obtained from BD-donors will be compared with islets recovered from human patients subjected to pancreatectomy for benign pancreatic tumors...
- International Medical Conference of Congenital HyperinsulinismCharles Stanley; Fiscal Year: 2006..Many require surgical treatment with near-total pancreatectomy to control hypoglycemia...
- ISLET-KIDNEY TRANSPLANTS FOR TREATMENT OF DIABETIC ESRDDavid Sachs; Fiscal Year: 2003..Specifically, in phase I (R21) we will: 1) Determine the optimal donor pancreatectomy requirements for clinical applicability; 2) Compare the efficacy of IK in maintaining euglycemia following ..
- Islet Transplantation with Chimeric Donor PigsWilliam Beschorner; Fiscal Year: 2007..In a pilot study, we have cured two diabetic rhesus monkeys (total pancreatectomy) with pig islet transplants...
- ISLET TOLERANCE INDUCTION BASED ON ANTI-CD154 ANTIBODYAldo Rossini; Fiscal Year: 2006..antibody will induce permanent islet allograft survival in humans with diabetes mellitus secondary to surgical pancreatectomy. We further hypothesize that these islet allografts will survive in the absence of chronic immunosuppression...
- Foxm 1b endocrine pancreas growth and regenerationMaureen Gannon; Fiscal Year: 2009..mice with a pancreas-specific Foxml deletion to examine its role in pancreas regeneration following partial pancreatectomy. Mice lacking Foxml in their entire pancreas were glucose intolerant at 6 weeks of age and overtly diabetic by ..
- GLP-1 regulation of endocrine pancreas growthDIVA DE LEON; Fiscal Year: 2001..these hypotheses, an antagonist of GLP-l receptor will be used to block GLP-1 action in mice after partial pancreatectomy. In a parallel approach, we will evaluate pancreatic regeneration in a GLP-1 receptor null mouse model...
- GLUCOSE HOMEOSTASIS AND THE SURGICALLY ALTERED PANCREASJOHN HANKS; Fiscal Year: 1990..surgical alterations of the pancreas which have pathophysiologic consequence - reduced beta cell mass (80% pancreatectomy), systemic release of insulin (spleno-caval diversion) and denervation (autotransplantation)...
- Mechanisms of Beta cell Compensation and FailureJohn Leahy; Fiscal Year: 2007..This proposal makes use of a newly developed rat model, the 60% pancreatectomy Zucker rat that incorporates the characteristic features of human adipogenic diabetes - obesity, insulin ..
- Disparities in Surgical Outcomes and Hospital VolumeLeslie Boxer; Fiscal Year: 2005..This study will create a data-set of complex surgical care procedures (pancreatectomy for pancreatic cancer, esophageal resection for esophageal cancer, colectomy for colon cancer and lung ..
- Transcriptional Regulation of Pancreas Development and FunctionCATHERINE MAY; Fiscal Year: 2007..adult p-cell expansion in to increased metabolic demands of pregnancy, high fat diet feeding and partial pancreatectomy using an inducible Cre-recombinase system...
- Beta-cell Compensation in Partial Pancreatectomy MiceJOHN L LEAHY; Fiscal Year: 2010..such as occurs in evolving type 1 diabetes, likely also type 2 diabetes, using the experimental model of 60% pancreatectomy (Px) in normally insulin sensitive rodents...
- Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)Christian Schmidt; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Influence of Tumor Immunogenicity to ImmunotherapyJeffrey Norton; Fiscal Year: 2006..unreadable] [unreadable]..
- Effect of exendin-(9-39) on glucose metabolism in subjects with hyperinsulinismDIVA DE LEON; Fiscal Year: 2008..Most patients are unresponsive to available medical therapy and require partial pancreatectomy to control the hypoglycemia, resulting in prolonged hospital stays, high risk for life-threatening ..
- INJURY TO LIVER SINUSOIDAL ENDOTHELIAL CELLSSteven Strasberg; Fiscal Year: 2003..A potentially beneficial improvements in preservation solutions are identified they will be tested in whole isolated livers and by transplantation in the rat. ..
- Role of Somatostatin Receptors in Pancreatic CancerWilliam Fisher; Fiscal Year: 2003..Since somatostatin expression has been demonstrated in other tumor types, the findings may also be relevant to other cancers. ..
- Development of Chronic Pancreatitis BiomarkersTeresa A Brentnall; Fiscal Year: 2010..An accurate biomarker for chronic pancreatitis would be of enormous clinical benefit and could save time and costs in comparison to the current gold standard of endoscopic testing for the disease. ..
- Role of GLP-1 in disorders of carbohydrate metabolism in childrenDIVA DE LEON; Fiscal Year: 2008....
- Biomarkers of UC TumorigenesisTeresa A Brentnall; Fiscal Year: 2010..Both of these goals will help provide the underpinnings for development of cancer prevention strategies in the future. ..
- Pancreatic Cancer Protein Biomarkers for Early DetectionTeresa A Brentnall; Fiscal Year: 2010....
- A Method for Validating Gene - Disease AssociationsColin Begg; Fiscal Year: 2004..abstract_text> ..
- Sugar-sweetened Beverages and Weight Gain in ChildrenDavid Ludwig; Fiscal Year: 2003..abstract_text> ..
- Recurrence of T1D in Pancreas TransplantationGeorge Burke; Fiscal Year: 2009..The knowledge gained should also be relevant to islet cell transplantation and spontaneous disease. ..
- CLINICAL AND BIOLOGICAL BASIS OF 18F-FDG PET IN CANCERYuman Fong; Fiscal Year: 2001..abstract_text> ..
- Liver Regeneration in Man--Effects or Adjuvant TherapyYuman Fong; Fiscal Year: 2005....
- VEGF Promotes Pancreatic Tumor Cell Arrest in the LiverJason Fleming; Fiscal Year: 2005..abstract_text> ..
- ISLET OF LANGERHANS GRAFT MONITORING BY MAGNETIC RESONANCE IMAGINGThierry Berney; Fiscal Year: 2008..unreadable] [unreadable]..
- Phenotypic Analysis of Young and Old Beta CellsSusan Bonner Weir; Fiscal Year: 2008..was generated comparing the beta cell-enriched cores of new and mature islets from the same rats after partial pancreatectomy (Px) and of islets from sham operated animals. The comparison of mature vs...
- Strategies to Identify In Vitro Islet ProgenitorsSusan Bonner Weir; Fiscal Year: 2007..Identifying such cell(s) would then direct focus on the expansion and differentiation of that cell type to a sustainable source of new beta cells. [unreadable] [unreadable]..
- MOLECULAR BASIS OF A NEW FORM OF HYPERINSULINISMCHARLES ALFRED STANLEY; Fiscal Year: 2010....
- Statistical Methods for Identifying Clonal TumorsColin B Begg; Fiscal Year: 2011....
- Glucose Regulation of Pancreatic Islet Gene ExperessionRODERICK PAUL ROBERTSON; Fiscal Year: 2010..We will study whether increasing antioxidant protection protects these cells and prevents deterioration of glucose control in diabetes. ..
- Gene Expression in Prediabetes: Potential Role of PGC-1MARY PATTI; Fiscal Year: 2006..abstract_text> ..
- Glycemic Index, Obesity, Insulin Resistance and CVD RiskDavid Ludwig; Fiscal Year: 2005..The project's key personnel and consultants include individuals with a diversity of expertise and perspective, ensuring a rigorous and impartial evaluation of study hypotheses. ..
- Popular Diets, Metabolism, and CVD RiskDavid Ludwig; Fiscal Year: 2008..This study should have major public health implications to the millions of Americans currently following diets to decrease body weight and risk for CVD. ..
- SURGERY AND INTESTINAL ADAPTATIONStanley Ashley; Fiscal Year: 2005..We anticipate that the results of these studies will provide a basis for further clinical trials designed to test the therapeutic potential of GLP-2 in human disease. ..