pancreatectomy

Summary

Summary: Surgical removal of the pancreas. (Dorland, 28th ed)

Top Publications

  1. ncbi Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    Yuval Dor
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 429:41-6. 2004
  2. ncbi Systematic review and meta-analysis of technique for closure of the pancreatic remnant after distal pancreatectomy
    H P Knaebel
    Department of General, Visceral and Trauma Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Br J Surg 92:539-46. 2005
  3. ncbi Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition
    Moritz N Wente
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Surgery 142:20-5. 2007
  4. pmc Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases
    Jorg Kleeff
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 245:573-82. 2007
  5. pmc Laparoscopic vs open distal pancreatectomy for solid pseudopapillary tumor of the pancreas
    Ren Chao Zhang
    Ren Chao Zhang, Jia Fei Yan, Xiao Wu Xu, Ke Chen, Harsha Ajoodhea, Yi Ping Mou, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
    World J Gastroenterol 19:6272-7. 2013
  6. ncbi Distal pancreatectomy: does the method of closure influence fistula formation?
    Maureen K Sheehan
    Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA
    Am Surg 68:264-7; discussion 267-8. 2002
  7. ncbi Robotic distal pancreatectomy: cost effective?
    Joshua A Waters
    Department of Surgery, Indiana University, Indianapolis, IN 46202, USA
    Surgery 148:814-23. 2010
  8. ncbi Islet autotransplant outcomes after total pancreatectomy: a contrast to islet allograft outcomes
    David E R Sutherland
    Department of Surgery, Division of Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 86:1799-802. 2008
  9. ncbi Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial
    Markus K Diener
    Study Centre of the German Surgical Society and Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Lancet 377:1514-22. 2011
  10. pmc Glucose metabolism in 105 children and adolescents after pancreatectomy for congenital hyperinsulinism
    Jacques Beltrand
    Pediatric Endocrinology and Diabetes, Hopital Necker Enfants Malades, Université Paris Descartes Sorbonne Paris Cité, Paris, France
    Diabetes Care 35:198-203. 2012

Detail Information

Publications354 found, 100 shown here

  1. ncbi Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    Yuval Dor
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 429:41-6. 2004
    ..rather than pluripotent stem cells, are the major source of new beta-cells during adult life and after pancreatectomy in mice...
  2. ncbi Systematic review and meta-analysis of technique for closure of the pancreatic remnant after distal pancreatectomy
    H P Knaebel
    Department of General, Visceral and Trauma Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Br J Surg 92:539-46. 2005
    Appropriate closure of the pancreatic remnant after distal pancreatectomy is still debated. A variety of procedures have been recommended to reduce the frequency of pancreatic fistula...
  3. ncbi Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition
    Moritz N Wente
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Surgery 142:20-5. 2007
    ..Because of these variations in the definition of what constitutes a PPH, the incidences of its occurrence are not comparable...
  4. pmc Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases
    Jorg Kleeff
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 245:573-82. 2007
    The objective of this study was to identify potential risk factors for mortality and morbidity after distal pancreatectomy, with special focus on the formation of pancreatic fistula.
  5. pmc Laparoscopic vs open distal pancreatectomy for solid pseudopapillary tumor of the pancreas
    Ren Chao Zhang
    Ren Chao Zhang, Jia Fei Yan, Xiao Wu Xu, Ke Chen, Harsha Ajoodhea, Yi Ping Mou, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
    World J Gastroenterol 19:6272-7. 2013
    To compare short- and long-term outcomes of laparoscopic vs open distal pancreatectomy for solid pseudopapillary tumor (SPT) of the pancreas.
  6. ncbi Distal pancreatectomy: does the method of closure influence fistula formation?
    Maureen K Sheehan
    Department of Surgery, Loyola University Medical Center, Maywood, Illinois, USA
    Am Surg 68:264-7; discussion 267-8. 2002
    The appropriate closure of the pancreatic remnant after distal pancreatectomy is still debated. Suture techniques, stapled closure, and pancreaticoenteric anastomosis all have their supporters...
  7. ncbi Robotic distal pancreatectomy: cost effective?
    Joshua A Waters
    Department of Surgery, Indiana University, Indianapolis, IN 46202, USA
    Surgery 148:814-23. 2010
    ..This study compares the costs and the outcomes of open, laparoscopic, and robotic distal pancreatectomies. We hypothesized that robotic distal pancreatectomy is cost-effective.
  8. ncbi Islet autotransplant outcomes after total pancreatectomy: a contrast to islet allograft outcomes
    David E R Sutherland
    Department of Surgery, Division of Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 86:1799-802. 2008
    ..In contrast, as shown here, islet autotransplants (IATs) show durable function and extended insulin-independence rates, despite a lower beta-cell mass...
  9. ncbi Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial
    Markus K Diener
    Study Centre of the German Surgical Society and Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Lancet 377:1514-22. 2011
    The ideal closure technique of the pancreas after distal pancreatectomy is unknown...
  10. pmc Glucose metabolism in 105 children and adolescents after pancreatectomy for congenital hyperinsulinism
    Jacques Beltrand
    Pediatric Endocrinology and Diabetes, Hopital Necker Enfants Malades, Université Paris Descartes Sorbonne Paris Cité, Paris, France
    Diabetes Care 35:198-203. 2012
    To describe the long-term metabolic outcome of children with congenital hyperinsulinism after near-total or partial elective pancreatectomy.
  11. ncbi Laparoscopic resection of exocrine carcinoma in central and distal pancreas results in a high rate of radical resections and long postoperative survival
    Irina Pavlik Marangos
    Interventional Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Surgery 151:717-23. 2012
    ..The objective of the present study was to investigate this question with the rate of R0 resection and long-term survival as endpoints...
  12. ncbi Novel method of stump closure for distal pancreatectomy with a 75% reduction in pancreatic fistula rate
    Joseph A Blansfield
    Geisinger Medical Center, Section of Surgical Oncology, 100 N Academy Avenue, MC 21 69, Danville, PA, USA
    J Gastrointest Surg 16:524-8. 2012
    Pancreatic fistula is a significant problem for patients undergoing distal pancreatectomy with fistula rates up to 61%. Fistulas lead to substantial morbidity...
  13. ncbi Solid-pseudopapillary tumor of the pancreas: CT and MRI features of 3 cases
    Dan Jun Dong
    Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
    Hepatobiliary Pancreat Dis Int 5:300-4. 2006
    ..Solid-pseudopapillary tumor of the pancreas is a rather rare but low-grade malignant tumor with good prognosis after surgical excision...
  14. ncbi Decrease in clinically relevant pancreatic fistula by coverage of the pancreatic remnant after distal pancreatectomy
    Matthias Hassenpflug
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Surgery 152:S164-71. 2012
    Pancreatic fistulas after distal pancreatectomy occur in up to 60% of patients with distal pancreatectomy...
  15. ncbi Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection?
    Alessandro Zerbi
    Pancreas Unit, Department of Surgery, S Raffaele Scientific Institute, V Olgettina 60, 20132, Milan, Italy
    Ann Surg Oncol 15:1161-8. 2008
    ..Pancreas is a possible site of metastases from renal cell carcinoma (RCC). The aim of this study was to define the role of surgery in their treatment...
  16. ncbi Can preoperative CA19-9 and CEA levels predict the resectability of patients with pancreatic adenocarcinoma?
    Young Choon Kim
    Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, Korea
    J Gastroenterol Hepatol 24:1869-75. 2009
    ..We aimed to explore the predictive ability of preoperative carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) levels for assessing tumor resectability (R0 resection) in patients with pancreatic adenocarcinoma...
  17. ncbi Distal pancreatectomy with preservation of the spleen
    Andrew L Warshaw
    Department of Surgery, Massachusetts General Hospital, 55 Fruit St, WHT506, Boston, MA 02114 2696, USA
    J Hepatobiliary Pancreat Sci 17:808-12. 2010
    Distal pancreatectomy (resection of the pancreatic body and tail) can be performed with or without preservation of the spleen...
  18. ncbi A surgical and pathological based classification of resective treatment of pancreatic cancer. Summary of an international workshop on surgical procedures in pancreatic cancer
    S Pedrazzoli
    Dipartimento di Scienze Mediche e Chirurgiche, Semeiotica Chirurgica, University of Padova, Italy
    Dig Surg 16:337-45. 1999
    The extent of pancreatic resection and lymphadenectomy, both for Kausch-Whipple pancreatoduodenectomy and for left pancreatectomy, is variable between surgeons, according to their training.
  19. ncbi Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases
    Laura H Tang
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 29:512-9. 2005
    ..The possibility that these tumors represent high-grade malignant transformation of a conventional low-grade SPT is proposed...
  20. ncbi Conventional laparoscopic and robot-assisted spleen-preserving pancreatectomy: does da Vinci have clinical advantages?
    Chang Moo Kang
    Division of Biliopancreas, Department of Surgery, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul, 120 752, Korea
    Surg Endosc 25:2004-9. 2011
    Function-preserving minimally invasive pancreatectomy is thought to be an ideal approach for pancreatic benign and borderline malignant lesions requiring pancreatectomy...
  21. ncbi Prognostic score predicting survival after resection of pancreatic neuroendocrine tumors: analysis of 3851 patients
    Karl Y Bilimoria
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Ann Surg 247:490-500. 2008
    ..The objective of this study was to identify factors predicting survival after pancreatectomy for PNETs and to establish a postresection prognostic score.
  22. pmc A selective approach to the resection of cystic lesions of the pancreas: results from 539 consecutive patients
    Peter J Allen
    Memorial Sloan Kettering Cancer Center, USA
    Ann Surg 244:572-82. 2006
    ..To define a group of patients with pancreatic cysts who do not require resection...
  23. ncbi Pancreatic resection of isolated metastases from nonpancreatic primary cancers
    Sushanth Reddy
    Department of Surgery, The Johns Hopkins University, 600 North Wolfe Street, Carnegie 681, Baltimore, Maryland 21287, USA
    Ann Surg Oncol 15:3199-206. 2008
    ..The goal of this study is to report the safety and efficacy of pancreatic resection for isolated metastatic cancers from nonpancreatic primary disease...
  24. ncbi The surgical management of congenital hyperinsulinemic hypoglycemia in infancy
    C Nihoul Fékété
    Department of Pediatric Surgery, Hopital des Enfants Malades, Paris, France
    J Pediatr Surg 39:267-9. 2004
    ..it leads to complete recovery without diabetes; on the contrary, diffuse CHI can only be cured by near-total pancreatectomy, and medical treatment, if efficient, is preferable...
  25. ncbi Influence of resection margins and treatment on survival in patients with pancreatic cancer: meta-analysis of randomized controlled trials
    Giovanni Butturini
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, 5th Floor, UCD Bldg, Daulby St, Liverpool L69 3GA, England
    Arch Surg 143:75-83; discussion 83. 2008
    ..To assess the influence of resection margins and adjuvant chemoradiotherapy or chemotherapy on survival for patients with pancreatic cancer by meta-analysis of individual data from randomized controlled trials...
  26. pmc Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma
    K Motojima
    Second Department of Surgery, Nagasaki University School of Medicine, Japan
    Ann Surg 217:138-43. 1993
    ..These results imply that total pancreatectomy for eliminating tumor recurrence due to multicentricity may not be warranted.
  27. ncbi Pancreatic resection for M1 pancreatic ductal adenocarcinoma
    Shailesh V Shrikhande
    Department of Gastrointestinal Surgical Oncology, Tata Memorial Hospital, Ernest Borges Marg, Parel, Mumbai, 400012, India
    Ann Surg Oncol 14:118-27. 2007
    ..Improved safety of pancreatic surgery has led to consideration of more aggressive approaches, such as resection for primary pancreatic ductal adenocarcinoma (PDAC) with metastatic disease (M1)...
  28. pmc National failure to operate on early stage pancreatic cancer
    Karl Y Bilimoria
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Ann Surg 246:173-80. 2007
    ..Our objective was to evaluate utilization of surgery in early stage disease and identify factors predicting failure to undergo surgery...
  29. ncbi Renal cell carcinoma metastatic to the pancreas: results of surgical management
    T A Sohn
    Department of Surgery, The Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Baltimore, MD 21287
    J Gastrointest Surg 5:346-51. 2001
    ..Of those, six underwent pancreaticoduodenectomy and two underwent distal pancreatectomy, whereas the two remaining patients underwent total pancreatectomy for extensive tumor involvement throughout ..
  30. ncbi Middle pancreatectomy: safety and long-term results
    Toshio Shikano
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Surgery 147:21-9. 2010
    Pancreaticoduodenectomy and distal pancreatectomy for lesions of the neck or body of the pancreas sacrifice a large amount of normal pancreatic tissue...
  31. ncbi Vascular resection and reconstruction for pancreatic malignancy: a single center survival study
    Mohammad Al-Haddad
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    J Gastrointest Surg 11:1168-74. 2007
    ..Recently, several centers have introduced portal and superior mesenteric vein resection and reconstruction during extended pancreatectomy, rendering the previously inoperable cases resectable.
  32. ncbi Totally laparoscopic Roux-en-Y duct-to-mucosa pancreaticojejunostomy after middle pancreatectomy: a consecutive nine-case series at a single institution
    Fernando Rotellar
    Departments of General and Abdominal Surgery, University Clinic of Navarre, University of Navarre, Pamplona, Spain
    Ann Surg 247:938-44. 2008
    ..To present the results of a series of laparoscopic middle pancreatectomies with roux-en-Y duct-to-mucosa pancreaticojejunostomy...
  33. ncbi Robotic spleen-preserving distal pancreatectomy. A case report
    C Vasilescu
    Department of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania
    Acta Chir Belg 109:396-9. 2009
    Distal pancreatectomy (DP) is the removal of the pancreatic tissue at the left side of the superior mesenteric vein and it is traditionally approached by an open or laparoscopic exposure...
  34. ncbi A multicenter analysis of distal pancreatectomy for adenocarcinoma: is laparoscopic resection appropriate?
    David A Kooby
    Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Am Coll Surg 210:779-85, 786-7. 2010
    As compared with open distal pancreatectomy (ODP), laparoscopic distal pancreatectomy (LDP) affords improved perioperative outcomes. The role of LDP for patients with pancreatic ductal adenocarcinoma (PDAC) is not defined.
  35. ncbi Early versus late drain removal after standard pancreatic resections: results of a prospective randomized trial
    Claudio Bassi
    Department of Surgery, G B Rossi Hospital, University of Verona, Verona, Italy
    Ann Surg 252:207-14. 2010
    ..The role of surgically placed intra-abdominal drainages after pancreatic resections has not been clearly established. In particular, their effect on morbidity rates and the optimal timing for their removal remains controversial...
  36. ncbi Risk factors for pancreatic leak after distal pancreatectomy
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Surg 250:277-81. 2009
    ..We sought to evaluate the incidence of and identify risk factors for the development of PL in patients undergoing distal pancreatectomy (DP) at a single high-volume institution.
  37. ncbi Prognostic factors for survival after extended pancreatectomy for pancreatic head cancer: influence of resection margin status on survival
    Koichi Kato
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pancreas 38:605-12. 2009
    ..The aim of this study was to examine the influence of resection margin status on survival after extended radical resection for pancreatic head cancer...
  38. pmc Implications and cost of pancreatic leak following distal pancreatic resection
    J Ruben Rodriguez
    Center for Clinical Effectiveness in Surgery, Harvard Medical School, Boston, USA
    Arch Surg 141:361-5; discussion 366. 2006
    ..We sought to provide an economic framework for potential interventions aimed at reducing its occurrence...
  39. ncbi Laparoscopic distal pancreatectomy and open distal pancreatectomy: a nonrandomized comparative study
    Toshifumi Matsumoto
    Department of Surgery I, Oita University Faculty of Medicine, Oita, Japan
    Surg Laparosc Endosc Percutan Tech 18:340-3. 2008
    Although laparoscopic distal pancreatectomy (LDP) is technically feasible, its benefits remain uncertain. The purpose of this study was to compare the clinical results of LDP and open distal pancreatectomy (ODP)...
  40. ncbi Laparoscopic central pancreatectomy: single institution experience of 6 patients
    Antonio Sa Cunha
    Department of Digestive Surgery, Haut Leveque Hospital, CHU Bordeaux, Bordeaux, France
    Surgery 142:405-9. 2007
    Medial pancreatectomy is an alternative technique for benign or low-grade malignant tumors of the neck of the pancreas. We describe our experience of laparoscopic central pancreatectomy.
  41. ncbi Curative laparoscopic resection for pancreatic neoplasms: a critical analysis from a single institution
    Laureano Fernandez-Cruz
    Surgical Department, ICMD Hospital Clínic de Barcelona, Villarroel, 170, 08036 Barcelona, Spain
    J Gastrointest Surg 11:1607-21; discussion 1621-2. 2007
    ..6%). Laparoscopic spleen-preserving distal pancreatectomy (Lap SPDP) was performed in 52 patients (63...
  42. ncbi Intramuscular autotransplantation of pancreatic islets in a 7-year-old child: a 2-year follow-up
    E Rafael
    Department of Surgery, Karolinska Institutet, Karolinska University Hospital in Huddinge, Stockholm, Sweden
    Am J Transplant 8:458-62. 2008
    A 7-year-old girl with severe hereditary pancreatitis underwent total pancreatectomy. A total of 160,000 islet equivalents (6400 islet/kg) were transplanted to the brachioradialis muscle of the right forearm...
  43. ncbi Peri-operative mortality and long-term survival after total pancreatectomy for pancreatic adenocarcinoma: a population-based perspective
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Surg Oncol 99:87-92. 2009
    Many surgeons perceive total pancreatectomy (TP) for pancreatic adenocarcinoma to be associated with inferior outcomes compared to partial pancreatectomy (PP), such as pancreaticoduodenectomy (PD) and distal pancreatectomy (DP)...
  44. ncbi A single-institution prospective study of laparoscopic pancreatic resection
    Antonio Sa Cunha
    Department of Digestive Surgery, Centre Hospitalier Universitaire de Bordeaux, Avenue de Magellan, Pessac 33604, France
    Arch Surg 143:289-95; discussion 295. 2008
    ..Laparoscopic pancreatic resection can safely duplicate all of the open pancreatic procedures...
  45. ncbi Radical antegrade modular pancreatosplenectomy procedure for adenocarcinoma of the body and tail of the pancreas: ability to obtain negative tangential margins
    Steven M Strasberg
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 204:244-9. 2007
    ..We now present results of treatment of patients with adenocarcinoma using RAMPS with particular reference to the ability of this procedure to obtain negative tangential margin rates...
  46. pmc Laparoscopic distal pancreatectomy is as safe and feasible as open procedure: a meta-analysis
    Kun Xie
    Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
    World J Gastroenterol 18:1959-67. 2012
    To evaluate the feasibility and safety of laparoscopic distal pancreatectomy (LDP) compared with open distal pancreatectomy (ODP).
  47. ncbi β-Cell replication and islet neogenesis following partial pancreatectomy
    Seung Hee Lee
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Islets 3:188-95. 2011
    Partial pancreatectomy is one of the most commonly used models in the study of β-cell regeneration...
  48. ncbi [Distal pancreatic resection--indications, techniques and complications]
    U Adam
    , Germany
    Zentralbl Chir 126:908-12. 2001
    ..METHODS: We analyzed the prospectively documented perioperative data of 41 patients undergoing distal pancreatectomy between 1994 and 2001...
  49. ncbi Robotic left pancreatectomy for pancreatic solid pseudopapillary tumor
    Dimitrios Ntourakis
    Pôle des Pathologies Digestives, Hépatiques et de la Transplantation, Hôpital de Hautepierre Hôpitaux Universitaires de Strasbourg, Universite de Strasbourg, Strasbourg, France
    Ann Surg Oncol 18:642-3. 2011
    ..1,2 Its resection could be performed by robotic technique with respect to oncological principles to avoid tumor cell dissemination.3..
  50. ncbi Robotic versus open pancreatectomy: a systematic review and meta-analysis
    Jie Zhang
    Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Ann Surg Oncol 20:1774-80. 2013
    ..The objective of this meta-analysis is to compare the clinical and oncologic safety and efficacy of robotic versus open pancreatectomy.
  51. pmc A noninvasive mucinous cystic neoplasm with intermediate-grade dysplasia of the pancreas and extensive squamous metaplasia: a case report with clinicopathological correlation
    Peifeng Li
    Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi an, Shaanxi, 710032, People s Republic of China
    Diagn Pathol 7:89. 2012
    ..The patient underwent cystojejunostomy, laparotomy and distal pancreatectomy consecutively because of the initial diagnosis of "pancreatic cyst"...
  52. ncbi Long-term results of resection of adenocarcinoma of the body and tail of the pancreas using radical antegrade modular pancreatosplenectomy procedure
    Jonathan B Mitchem
    Section of Hepato Pancreato Biliary Surgery, Washington University in St Louis, St Louis, MO 63110, USA
    J Am Coll Surg 214:46-52. 2012
    ..The purpose of this report is to provide long-term survival results...
  53. ncbi Robot-assisted minimally invasive distal pancreatectomy is superior to the laparoscopic technique
    Mustapha Daouadi
    Division of GI Surgical Oncology, General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
    Ann Surg 257:128-32. 2013
    Laparoscopic distal pancreatectomy (LDP) reduces postoperative morbidity, hospital stay, and recovery as compared with open distal pancreatectomy...
  54. ncbi Is it worthwhile to preserve adult spleen in laparoscopic distal pancreatectomy? Perioperative and patient-reported outcome analysis
    Sung Hoon Choi
    Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, Ludlow Faculty Research Building 204, 50 Yonsei ro, Seodaemun gu, Seoul, 120 752, Korea
    Surg Endosc 26:3149-56. 2012
    Despite the emphasis on its role, the spleen has commonly been removed in distal pancreatectomy. We designed this study to evaluate the efficacy of spleen salvage during laparoscopic distal pancreatectomy for patients with benign and ..
  55. ncbi Efficacy of an absorbable fibrin sealant patch (TachoSil) after distal pancreatectomy: a multicenter, randomized, controlled trial
    Marco Montorsi
    Department of General Surgery, University of Milan, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy
    Ann Surg 256:853-9; discussion 859-60. 2012
    To evaluate the role of an absorbable fibrin sealant patch (TachoSil) in reducing postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).
  56. pmc Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entity
    T A Sohn
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-4606, USA
    Ann Surg 234:313-21; discussion 321-2. 2001
    ..pancreas or diffusely involved the gland, with 70% being resected via pancreaticoduodenectomy, 22% via total pancreatectomy, and 8% via distal pancreatectomy...
  57. ncbi Management of remnant pancreatic stump fto prevent the development of postoperative pancreatic fistulas after distal pancreatectomy: current evidence and our strategy
    Isamu Makino
    Department of Gastroenterologic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Surg Today 43:595-602. 2013
    Distal pancreatectomy (DP) is the most common surgical procedure for treating benign and malignant lesions in the body or tail of the pancreas...
  58. ncbi Current status of robot-assisted laparoscopic pancreaticoduodenectomy and distal pancreatectomy: a comprehensive review
    Eric C H Lai
    Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China
    Asian J Endosc Surg 6:158-64. 2013
    This article reviews the current status of robot-assisted laparoscopic pancreaticoduodenectomy and distal pancreatectomy.
  59. ncbi High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinoma
    C Bassi
    Pancreatic Unit, Department of Surgical and Gastroenterological Sciences, Policlinico B Roma, Verona University, Verona, Italy
    Br J Surg 90:555-9. 2003
    ..Pancreatic metastases from renal cell carcinoma are rare but highly resectable. The aim of this study was to review a series of patients with this condition...
  60. pmc Incidental intraoperative discovery of a pancreatic neuroendocrine tumor associated with chronic pancreatitis
    Valeriu Surlin
    Department of Surgery, University of Medicine and Pharmacy of Craiova, Petru Rares 2, 200393 Craiova, Romania
    Diagn Pathol 7:132. 2012
    ..The tumor of 1.5 cm size was well differentiated and confined to the pancreas, and was resected by a distal splenopancreatectomy...
  61. ncbi Robot-assisted spleen-preserving distal pancreatectomy: a single surgeon's experiences and proposal of clinical application
    Ho Kyoung Hwang
    Division of Hepatobiliary and Pancreas, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul 120 752, South Korea
    Surg Endosc 27:774-81. 2013
    ..laparoscopic techniques are usually required for safe and successful laparoscopic spleen-preserving distal pancreatectomy. The unique characteristics of robotic surgical system are thought to be useful for this minimally invasive ..
  62. ncbi Enucleation in pancreatic surgery: indications, technique, and outcome compared to standard pancreatic resections
    Thilo Hackert
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Langenbecks Arch Surg 396:1197-203. 2011
    ..The aim of the study was to evaluate the indications, technique, and outcome of this limited local approach compared to major resections...
  63. ncbi Laparoscopic distal pancreatectomy: evolution of a technique at a single institution
    Shiva Jayaraman
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Am Coll Surg 211:503-9. 2010
    ..The pancreas remains an organ for which routine laparoscopic resection is uncommon...
  64. ncbi Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients
    Feng Yang
    Pancreatic Disease Institute, Department of Surgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
    Am J Surg 198:210-5. 2009
    ..The aim of this study is to describe the clinicopathologic features and surgical management of this disease in our institution...
  65. ncbi Perioperative and long-term results after left pancreatectomy: a single-institution, non-randomized, comparative study between open and laparoscopic approach
    Giovanni Butturini
    Department of Surgery, G B Rossi Hospital, University of Verona, P le L A Scuro 10, 37134 Verona, Italy
    Surg Endosc 25:2871-8. 2011
    ..In this study, we provide a nonrandomized comparison between laparoscopic and open left pancreatectomy (OLP) for benign and borderline tumors, focusing on both perioperative and long-term results.
  66. ncbi A simple and safe anastomosis in pancreaticogastrostomy using mattress sutures
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Am J Surg 196:130-4. 2008
    ..Postoperative amylase levels in the drainage fluid decreased significantly and none of the 17 patients developed pancreatic fistula formation. The technique is simple and shortens the time required for anastomosis...
  67. ncbi Blind distal pancreatectomy for occult insulinoma, an inadvisable procedure
    Boaz Hirshberg
    Division of Intramural Research, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    J Am Coll Surg 194:761-4. 2002
    ..Blind distal pancreatectomy has been advocated for occult insulinomas not detected on imaging studies or during abdominal exploration...
  68. ncbi Parenchyma-preserving resections for small nonfunctioning pancreatic endocrine tumors
    Massimo Falconi
    Chirurgia Generale B Pancreas Unit, Department of Surgery, University of Verona, Policlinico GB Rossi, Verona, Italy
    Ann Surg Oncol 17:1621-7. 2010
    Parenchyma-preserving resections (PPRs), including enucleation and middle pancreatectomy (MP), are accepted procedures for insulinomas, but their role in the treatment of nonfunctioning pancreatic endocrine tumors (NF-PETs) is debated...
  69. ncbi Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients
    Marcel C C Machado
    Department of Gastroenterology, University of Sao Paulo, Sao Paulo, Brazil
    Surgery 143:29-34. 2008
    ..Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential. This study examines clinical differences and prognosis between male and female patients...
  70. ncbi Postoperative pancreatic fistulas are not equivalent after proximal, distal, and central pancreatectomy
    Wande Pratt
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Gastrointest Surg 10:1264-78; discussion 1278-9. 2006
    ..and grade A patients were identical across resection types, though grade A fistula was more common in distal pancreatectomy. For each resection type, length of stay and costs progressively increased with grades B and C...
  71. ncbi Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival
    Chandrajit P Raut
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Ann Surg Oncol 13:582-94. 2006
    ..This study evaluated the outcome after pancreatectomy for IPMN according to the pancreatic transection margin status and the presence or absence of invasive ..
  72. ncbi Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy
    Keiko Y Hayashi
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Arch Histol Cytol 66:163-74. 2003
    ..and differentiation dynamics of pancreatic endocrine cells in the rat pancreas 1 to 28 days after a 90% pancreatectomy. Regeneration of endocrine cells started immediately after pancreatectomy...
  73. ncbi Laparoscopic distal pancreatectomy: a comparative study
    C N Tang
    Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
    Hepatogastroenterology 54:265-71. 2007
    This article aims to describe the different techniques of laparoscopic distal pancreatectomy and to compare the results of our series of 9 laparoscopic resections against the historical open control in the same institution...
  74. ncbi Systematic review of minimally invasive pancreatic resection
    Christopher D Briggs
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, Bio centre, University of Leicester, University Road, Leicester LE1 7RH, UK
    J Gastrointest Surg 13:1129-37. 2009
    ..This article reviews the current published literature on the safety and efficacy of minimally invasive surgery of the pancreas...
  75. ncbi National complication rates after pancreatectomy: beyond mere mortality
    Jessica P Simons
    Department of Surgery, UMass Surgical Outcomes Analysis and Research, University of Massachusetts Medical School, 55 Lake Avenue North, Suite S3 752, Worcester, MA 01655, USA
    J Gastrointest Surg 13:1798-805. 2009
    ..National studies on in-hospital pancreatic outcomes have focused on mortality. Non-fatal morbidity affects a greater proportion of patients...
  76. pmc Intraductal papillary mucinous neoplasms of the pancreas: an updated experience
    Taylor A Sohn
    Departments of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ann Surg 239:788-97; discussion 797-9. 2004
    ..To update the authors' experience with intraductal papillary mucinous neoplasms (IPMNs) of the pancreas...
  77. pmc Clinical value of serum CA19-9 levels in evaluating resectability of pancreatic carcinoma
    Shun Zhang
    Department of Hepatobiliary Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China
    World J Gastroenterol 14:3750-3. 2008
    ..To evaluate the clinical value of serum CA19-9 levels in predicting the respectability of pancreatic carcinoma according to receiver operating characteristic (ROC) curve analysis...
  78. pmc Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional series
    Sushanth Reddy
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Am Coll Surg 208:950-7; discussion 957-9. 2009
    ..Solid-pseudopapillary neoplasms (SPNs) are rare pancreatic tumors with malignant potential. Clinicopathologic characteristics and outcomes of patients with SPN were reviewed...
  79. ncbi Outcome after pancreatectomy and islet autotransplantation in a pediatric population
    Melena D Bellin
    Department of Pediatrics, Division of Endocrinology, University of Minnesota, 516 Delaware St SE, Minneapolis, MN 55455, USA
    J Pediatr Gastroenterol Nutr 47:37-44. 2008
    Little is known regarding outcomes after pancreatectomy and islet autotransplantation for chronic pancreatitis in pediatric patients...
  80. ncbi Significance of splenic vein thrombosis in chronic pancreatitis
    Anil K Agarwal
    Department of Gastrointestinal Surgery, Gobind Ballabh Pant Hospital and Maulana Azad Medical College, New Delhi 110002, India
    Am J Surg 196:149-54. 2008
    ..Splenic vein thrombosis leading to sinistral portal hypertension and variceal bleeding is a complication of chronic pancreatitis. The management of these patients without variceal bleeding remains controversial...
  81. ncbi Tumor-node-metastasis staging of pancreatic adenocarcinoma
    Matthew H G Katz
    Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 58:111-25. 2008
    ....
  82. ncbi Surgical treatment of pancreatic serous cystadenoma: aggressive for operations but limited resections
    Ji Shiang Hung
    Department of Surgery, National Taiwan University Hospital Yunlin Branch, Yunlin County, Taiwan, Republic of China
    Pancreas 35:358-60. 2007
    ..Serous cystadenomas of the pancreas are being increasingly identified as the advancement of the diagnostic abdominal imaging. However, the optimal timing of surgical intervention for this disease remains controversial...
  83. pmc The effect of age on short-term outcomes after pancreatic resection: a population-based study
    Taylor S Riall
    Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0542, USA
    Ann Surg 248:459-67. 2008
    ..To use a large population-based cohort to determine age-dependent short-term outcomes after pancreatic resection...
  84. ncbi Metaanalysis of trials comparing minimally invasive and open distal pancreatectomies
    Giuseppe R Nigri
    Department of Surgery, St Andrea Hospital, Sapienza University of Rome, 5 Ovest, Via di Grottarossa 1035, 00189, Rome, Italy
    Surg Endosc 25:1642-51. 2011
    The current literature suggests that minimally invasive distal pancreatectomy (MIDP) is associated with faster recovery and less morbidity than open surgery...
  85. ncbi Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia
    F Menni
    , , Centre Hospitalier Universitaire Necker-Enfants Malades, Paris, France
    Pediatrics 107:476-9. 2001
    ..Thirty-six patients had infancy-onset hyperinsulinism, of whom 19 were treated medically and 17 underwent pancreatectomy (10 patients for a focal adenomatous hyperplasia and 7 for diffuse hyperinsulinism)...
  86. ncbi Single-center experience of laparoscopic left pancreatic resection in 359 consecutive patients: changing the surgical paradigm of left pancreatic resection
    Ki Byung Song
    Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Songpa Ku, Seoul, South Korea
    Surg Endosc 25:3364-72. 2011
    Laparoscopic distal pancreatectomy (LDP) is increasingly performed for lesions of the body and tail of the pancreas...
  87. ncbi Multiple proinsulin-secreting tumors of the pancreas treated by laparoscopic distal pancreatectomy and splenectomy
    Gary Clark
    Department of Surgery, Kaiser Permanente, Richmond, CA, USA
    World J Surg 33:397-9. 2009
    ..Laboratory testing can frequently result in data challenging to the clinician to confirm the biochemical diagnosis. Proinsulin, in addition to insulin levels, may be essential in evaluating and diagnosing an insulinoma...
  88. ncbi Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer
    Andrew V Biankin
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
    Gastroenterology 137:558-68, 568.e1-11. 2009
    Current methods of preoperative staging and predicting outcome following pancreatectomy for pancreatic cancer (PC) are inadequate...
  89. ncbi Pancreatic leak after left pancreatectomy is reduced following main pancreatic duct ligation
    M M Bilimoria
    Department of Surgical Oncology, Box 444, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 4009, USA
    Br J Surg 90:190-6. 2003
    Although much is known about the long-term outcome of patients undergoing left (distal) pancreatectomy for malignancy, comparatively little is known about the optimal management strategy for the residual transected pancreatic parenchyma ..
  90. ncbi Laparoscopic left pancreatectomy: complication risk score correlates with morbidity and risk for pancreatic fistula
    Sharon M Weber
    Section of Surgical Oncology, Department of Surgery, H4 752 Clinical Science Center, University of Wisconsin Hospital, Madison, WI, USA
    Ann Surg Oncol 16:2825-33. 2009
    Surgeons are performing laparoscopic left pancreatectomy (LLP) with increasing frequency; however, determinants of perioperative outcome after LLP are not well defined. We evaluated factors contributing to morbidity after LLP.
  91. ncbi Surgery insight: surgical management of pancreatic cancer
    Christoph W Michalski
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Nat Clin Pract Oncol 4:526-35. 2007
    ..This Review describes the current status of surgical treatment for pancreatic ductal adenocarcinoma, and highlights the new developments in this field...
  92. ncbi Solid pseudopapillary neoplasms of the pancreas: an updated experience
    Brian K P Goh
    Department of Surgery, Singapore General Hospital, Singapore
    J Surg Oncol 95:640-4. 2007
    ..The aim of this study is to report an update of the surgical experience at a single institution with these unusual tumors...
  93. pmc Necrotizing pancreatitis: contemporary analysis of 99 consecutive cases
    S W Ashley
    Department of Surgery, Brigham and Women s Hospital Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Ann Surg 234:572-9; discussion 579-80. 2001
    ..To analyze the impact of a conservative strategy of management in patients with necrotizing pancreatitis, reserving intervention for patients with documented infection or the late complications of organized necrosis...
  94. ncbi Outcome of paraaortic node-positive pancreatic head and bile duct adenocarcinoma
    Takanori Yoshida
    Department of Surgery I, Oita University Faculty of Medicine, Oita, Japan
    Am J Surg 187:736-40. 2004
    ..This retrospective study aimed to identify the clinicopathologic features and surgical results of paraaortic node-positive periampullary adenocarcinoma...
  95. ncbi The role of total pancreatectomy and islet autotransplantation for chronic pancreatitis
    Juan J Blondet
    Division of Surgical Critical Care Trauma, Department of Surgery, University of Minnesota, MMC 11, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Surg Clin North Am 87:1477-501, x. 2007
    Total pancreatectomy and islet autotransplantation are done for chronic pancreatitis with intractable pain when other treatment measures have failed, allowing insulin secretory capacity to be preserved, minimizing or preventing diabetes, ..
  96. ncbi Treatment guidelines for branch duct type intraductal papillary mucinous neoplasms of the pancreas: when can we operate or observe?
    Jin Young Jang
    Department of Surgery, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, South Korea
    Ann Surg Oncol 15:199-205. 2008
    ..However, no definite treatment guideline (with respect to surgery or observation) has been issued on the management of branch duct type IPMN...
  97. ncbi Single-centre experience of laparoscopic pancreatic surgery
    B I Røsok
    Division of Surgery, Section for Gastrointestinal Surgery, Oslo University Hospital OUH, Rikshospitalet, 0027 Oslo, Norway
    Br J Surg 97:902-9. 2010
    ..Laparoscopic resection is regarded as safe and feasible in selected patients with benign pancreatic tumours. Few data exist on laparoscopic surgery for malignant lesions and larger neoplasms in unselected patients...
  98. ncbi Surgical versus non-surgical treatment of congenital hyperinsulinism
    Kineret Mazor-Aronovitch
    Pediatric Endocrinology Unit, Edmond Safra Pediatric Medical Center, Tel Hashomer, Israel
    Pediatr Endocrinol Rev 6:424-30. 2009
    ..In its diffuse severe form, it is traditionally treated with over 95% pancreatectomy. However, even after this procedure normoglycemia is not always achieved...
  99. ncbi Total pancreatectomy with and without islet cell transplantation for chronic pancreatitis: a series of 85 consecutive patients
    Giuseppe Garcea
    Department of Hepatobiliary and Pancreatic Surgery, Leicester General Hospital, Leicester, United Kingdom
    Pancreas 38:1-7. 2009
    This study examined 85 consecutive patients undergoing total pancreatectomy (+/-islet cell transplant), examining pain relief, insulin requirements, and glycemic control postoperatively.
  100. ncbi Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for surgical treatment of chronic pancreatitis: a systematic review and meta-analysis
    Markus K Diener
    Department of General, Visceral and Trauma Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg 247:950-61. 2008
    ....
  101. ncbi The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial
    Micheal G Sarr
    Gastroenterology Research Unit AL 2 436, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Am Coll Surg 196:556-64; discussion 564-5; author reply 565. 2003
    b>Pancreatectomy can be complicated by pancreatic anastomotic leakage, causing major morbidity.

Research Grants63

  1. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010
    ..IR) baboons;(2) to examine the effects of an acute increase in insulin secretory demand (achieved by partial pancreatectomy, PPx) on [unreadable]-cell function, morphology and ultrastructure (with particular emphasis on IAPP and A[..
  2. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2013
    ..such as occurs in evolving type 1 diabetes, likely also type 2 diabetes, using the experimental model of 60% pancreatectomy (Px) in normally insulin sensitive rodents...
  3. Intervention of Pancreatic Oncogenic Pathways with Dietary Tocotrienol
    Mokenge P Malafa; Fiscal Year: 2012
    ..3) To perform a phase 1 a/b trial to investigate whether consumption of 4-tocotrienol for 2 weeks prior to pancreatectomy will induce p27 and alter Mek/Erk and PI3K/Akt signaling pathways leading to an inhibition of proliferation ..
  4. Novel Strategies to Increase Insulin Independence after Islet Autotransplantation
    Hongjun Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Total pancreatectomy with islet autotransplantation (TP-IAT) is currently being performed to treat intractable pain and to prevent "brittle" diabetes in well-selected patients with chronic pancreatitis...
  5. Islet and Mesenchymal Stem Cell Co-transplantation Prevents Onset of Diabetes
    Hongjun Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Total pancreatectomy and islet autotransplantation (TP-IAT) are currently being performed to treat intractable pain in selected patients with chronic pancreatitis (CP)...
  6. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    RODERICK PAUL ROBERTSON; Fiscal Year: 2013
    ..Our approach is to study intrahepatic islet function in patients with chronic pancreatitis who undergo total pancreatectomy and autoislet transplantation (TP/AIT) in both hepatic and nonhepatic sites...
  7. Islet Dysregulation in Infants with Congenital Hyperinsulinism
    CHARLES ALFRED STANLEY; Fiscal Year: 2013
    ..This includes one-third of diffuse HI cases that require pancreatectomy and half of cases that are responsive to medical treatment with diazoxide...
  8. Role of GLP-1 in Congenital Hyperinsulinism
    DIVA DEL CARMEN DE LEON; Fiscal Year: 2010
    ..Most patients are unresponsive to available medical therapy and require partial pancreatectomy to control the hypoglycemia, resulting in prolonged hospitalization, high risk for life-threatening ..
  9. Role of Neurogenic Inflammation in Pancreatic Cancer
    Brian M Davis; Fiscal Year: 2013
    ..The link between CP and PDAC is so strong that physicians often recommend prophylactic pancreatectomy for patients with severe CP. The mechanistic link between pancreatic inflammation and cancer is not known...
  10. Sitagliptin therapy to improve outcomes after islet autotransplantation.
    Melena D Bellin; Fiscal Year: 2013
    ..a randomized double-blinded controlled trial evaluating the effect of sitagliptin treatment following total pancreatectomy and islet autotransplant on insulin independence and islet function...
  11. Cell Lineage and Homeostasis of Pancreatic Beta Cells in the Aged
    JAKE ALDEN KUSHNER; Fiscal Year: 2013
    ..We will quantify beta-cell mass expansion of aged mice in response to regenerative stimuli, injury (partial pancreatectomy, pancreatic ductal ligation, streptozotocin mediated beta-cell loss) or diabetes therapies (exendin- 4, ..
  12. Characterizing the Role of Pancreatic Progenitors in Regeneration
    Michael Parsons; Fiscal Year: 2013
    ..destroying the acinar tissue;iii) A surgical procedure to remove a large portion of the pancreas (partial pancreatectomy)...
  13. Phase 2A Study of Exendin for the Treatment of Congenital Hyperinsulinism
    DIVA DEL CARMEN DE LEON; Fiscal Year: 2013
    ..Children affected by the most common form of CHI are unresponsive to medical therapy and require a near-total pancreatectomy shortly after birth for intractable hypoglycemia...
  14. Fuel Metabolism and insulin secretion in KATP-hyperinsulinism human islets
    Changhong Li; Fiscal Year: 2013
    ..Children with KATPHI are usually unresponsive to medical therapy and require pancreatectomy to control the hypoglycemia and prevent permanent brain damage...
  15. Role of Pulsatile Insulin Secretion
    PETER CAWOOD BUTLER; Fiscal Year: 2012
    ..In the proposed studies, we will first examine humans with an ~50% pancreatectomy and those with IFG/IGT compared to controls for pulsatile insulin secretion and insulin sensitivity...
  16. Antibody bead array technology for diagnosis of pre-invasive pancreatic cancer
    Peter Allen; Fiscal Year: 2012
    ..high-risk lesions to be resected prior to the development of an essentially incurable disease, and enable patients with low-risk lesions to avoid operation and spare them the physical, emotional, and financial costs of pancreatectomy.
  17. Smad regulation of pancreatic islet formation
    George K Gittes; Fiscal Year: 2012
    ..inhibitory smad7, in the regeneration of new beta cells in the adult mouse pancreas in response to a partial pancreatectomy. It appears that most new beta cells form from previous beta cells, but little or nothing is know about ..
  18. Magnetic Flow Sorter for Pancreatic Islet Isolation
    Paul W Todd; Fiscal Year: 2013
    ..of human pancreatic islets of Langerhans for therapeutic transplantation for the prevention of diabetes in pancreatectomy patients...
  19. Program Project,Restoration of Endocrine Pancreas Funct*
    JOEL HABENER; Fiscal Year: 2004
    ..of beta-cells via transplantation of stem/progenitor cells in animal models of diabetes (rat partial pancreatectomy). Project 2: Modulation of pancreatic islets for transplantation (PI: Dr...
  20. Pancreatic Intra-Islet Ducts
    George K Gittes; Fiscal Year: 2013
    ..however, in a genetically altered mouse model in which [unreadable]-cells do not proliferate after partial pancreatectomy, we describe a fairly dramatic sprouting of new ductal structures from existing large ducts after partial ..
  21. A Novel Method to Isolate Islet Cells
    JERRY KNOBELOCH; Fiscal Year: 2007
    ..In addition, auto-islet transplantation for persons undergoing pancreatectomy for chronic pancreatitis has been performed with increasing success...
  22. INSULIN AND PROTEIN SYNTHESIS AFTER RESISTANCE EXERCISE
    PETER FARRELL; Fiscal Year: 1999
    ..and the ability of muscle to hypertrophy due to chronic exercise will be elucidated using 70 and 90% partial pancreatectomy of mature (250g) rats...
  23. Data and Statistical Coordinating Center (DSCC) for the Collaborative Islet Trans
    Donald M Stablein; Fiscal Year: 2012
    ..episodes in persons with Type 1 diabetes or lacking pancreatic islets for any reason including therapeutic pancreatectomy or any loss of islet cell function...
  24. ISLET-KIDNEY TRANSPLANTS FOR TREATMENT OF DIABETIC ESRD
    David Sachs; Fiscal Year: 2006
    ..to reverse hyperglycemia in diabetic baboons; and 4) Develop non-invasive techniques for partial pancreatectomy, preparation of IK and IK removal for transplantation...
  25. Effects of brain-death on islet recovery and functional*
    John Thompson; Fiscal Year: 2006
    ..end, islets obtained from BD-donors will be compared with islets recovered from human patients subjected to pancreatectomy for benign pancreatic tumors...
  26. International Medical Conference of Congenital Hyperinsulinism
    Charles Stanley; Fiscal Year: 2006
    ..Many require surgical treatment with near-total pancreatectomy to control hypoglycemia...
  27. ISLET-KIDNEY TRANSPLANTS FOR TREATMENT OF DIABETIC ESRD
    David Sachs; Fiscal Year: 2003
    ..Specifically, in phase I (R21) we will: 1) Determine the optimal donor pancreatectomy requirements for clinical applicability; 2) Compare the efficacy of IK in maintaining euglycemia following ..
  28. Islet Transplantation with Chimeric Donor Pigs
    William Beschorner; Fiscal Year: 2007
    ..In a pilot study, we have cured two diabetic rhesus monkeys (total pancreatectomy) with pig islet transplants...
  29. ISLET TOLERANCE INDUCTION BASED ON ANTI-CD154 ANTIBODY
    Aldo Rossini; Fiscal Year: 2006
    ..antibody will induce permanent islet allograft survival in humans with diabetes mellitus secondary to surgical pancreatectomy. We further hypothesize that these islet allografts will survive in the absence of chronic immunosuppression...
  30. Foxm 1b endocrine pancreas growth and regeneration
    Maureen Gannon; Fiscal Year: 2009
    ..mice with a pancreas-specific Foxml deletion to examine its role in pancreas regeneration following partial pancreatectomy. Mice lacking Foxml in their entire pancreas were glucose intolerant at 6 weeks of age and overtly diabetic by ..
  31. GLP-1 regulation of endocrine pancreas growth
    DIVA DE LEON; Fiscal Year: 2001
    ..these hypotheses, an antagonist of GLP-l receptor will be used to block GLP-1 action in mice after partial pancreatectomy. In a parallel approach, we will evaluate pancreatic regeneration in a GLP-1 receptor null mouse model...
  32. GLUCOSE HOMEOSTASIS AND THE SURGICALLY ALTERED PANCREAS
    JOHN HANKS; Fiscal Year: 1990
    ..surgical alterations of the pancreas which have pathophysiologic consequence - reduced beta cell mass (80% pancreatectomy), systemic release of insulin (spleno-caval diversion) and denervation (autotransplantation)...
  33. Mechanisms of Beta cell Compensation and Failure
    John Leahy; Fiscal Year: 2007
    ..This proposal makes use of a newly developed rat model, the 60% pancreatectomy Zucker rat that incorporates the characteristic features of human adipogenic diabetes - obesity, insulin ..
  34. Disparities in Surgical Outcomes and Hospital Volume
    Leslie Boxer; Fiscal Year: 2005
    ..This study will create a data-set of complex surgical care procedures (pancreatectomy for pancreatic cancer, esophageal resection for esophageal cancer, colectomy for colon cancer and lung ..
  35. Transcriptional Regulation of Pancreas Development and Function
    CATHERINE MAY; Fiscal Year: 2007
    ..adult p-cell expansion in to increased metabolic demands of pregnancy, high fat diet feeding and partial pancreatectomy using an inducible Cre-recombinase system...
  36. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2010
    ..such as occurs in evolving type 1 diabetes, likely also type 2 diabetes, using the experimental model of 60% pancreatectomy (Px) in normally insulin sensitive rodents...
  37. Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)
    Christian Schmidt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. Influence of Tumor Immunogenicity to Immunotherapy
    Jeffrey Norton; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  39. Effect of exendin-(9-39) on glucose metabolism in subjects with hyperinsulinism
    DIVA DE LEON; Fiscal Year: 2008
    ..Most patients are unresponsive to available medical therapy and require partial pancreatectomy to control the hypoglycemia, resulting in prolonged hospital stays, high risk for life-threatening ..
  40. INJURY TO LIVER SINUSOIDAL ENDOTHELIAL CELLS
    Steven Strasberg; Fiscal Year: 2003
    ..A potentially beneficial improvements in preservation solutions are identified they will be tested in whole isolated livers and by transplantation in the rat. ..
  41. Role of Somatostatin Receptors in Pancreatic Cancer
    William Fisher; Fiscal Year: 2003
    ..Since somatostatin expression has been demonstrated in other tumor types, the findings may also be relevant to other cancers. ..
  42. Development of Chronic Pancreatitis Biomarkers
    Teresa A Brentnall; Fiscal Year: 2010
    ..An accurate biomarker for chronic pancreatitis would be of enormous clinical benefit and could save time and costs in comparison to the current gold standard of endoscopic testing for the disease. ..
  43. Role of GLP-1 in disorders of carbohydrate metabolism in children
    DIVA DE LEON; Fiscal Year: 2008
    ....
  44. Biomarkers of UC Tumorigenesis
    Teresa A Brentnall; Fiscal Year: 2010
    ..Both of these goals will help provide the underpinnings for development of cancer prevention strategies in the future. ..
  45. Pancreatic Cancer Protein Biomarkers for Early Detection
    Teresa A Brentnall; Fiscal Year: 2010
    ....
  46. A Method for Validating Gene - Disease Associations
    Colin Begg; Fiscal Year: 2004
    ..abstract_text> ..
  47. Sugar-sweetened Beverages and Weight Gain in Children
    David Ludwig; Fiscal Year: 2003
    ..abstract_text> ..
  48. Recurrence of T1D in Pancreas Transplantation
    George Burke; Fiscal Year: 2009
    ..The knowledge gained should also be relevant to islet cell transplantation and spontaneous disease. ..
  49. CLINICAL AND BIOLOGICAL BASIS OF 18F-FDG PET IN CANCER
    Yuman Fong; Fiscal Year: 2001
    ..abstract_text> ..
  50. Liver Regeneration in Man--Effects or Adjuvant Therapy
    Yuman Fong; Fiscal Year: 2005
    ....
  51. VEGF Promotes Pancreatic Tumor Cell Arrest in the Liver
    Jason Fleming; Fiscal Year: 2005
    ..abstract_text> ..
  52. ISLET OF LANGERHANS GRAFT MONITORING BY MAGNETIC RESONANCE IMAGING
    Thierry Berney; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  53. Phenotypic Analysis of Young and Old Beta Cells
    Susan Bonner Weir; Fiscal Year: 2008
    ..was generated comparing the beta cell-enriched cores of new and mature islets from the same rats after partial pancreatectomy (Px) and of islets from sham operated animals. The comparison of mature vs...
  54. Strategies to Identify In Vitro Islet Progenitors
    Susan Bonner Weir; Fiscal Year: 2007
    ..Identifying such cell(s) would then direct focus on the expansion and differentiation of that cell type to a sustainable source of new beta cells. [unreadable] [unreadable]..
  55. MOLECULAR BASIS OF A NEW FORM OF HYPERINSULINISM
    CHARLES ALFRED STANLEY; Fiscal Year: 2010
    ....
  56. Statistical Methods for Identifying Clonal Tumors
    Colin B Begg; Fiscal Year: 2011
    ....
  57. Glucose Regulation of Pancreatic Islet Gene Experession
    RODERICK PAUL ROBERTSON; Fiscal Year: 2010
    ..We will study whether increasing antioxidant protection protects these cells and prevents deterioration of glucose control in diabetes. ..
  58. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2006
    ..abstract_text> ..
  59. Glycemic Index, Obesity, Insulin Resistance and CVD Risk
    David Ludwig; Fiscal Year: 2005
    ..The project's key personnel and consultants include individuals with a diversity of expertise and perspective, ensuring a rigorous and impartial evaluation of study hypotheses. ..
  60. Popular Diets, Metabolism, and CVD Risk
    David Ludwig; Fiscal Year: 2008
    ..This study should have major public health implications to the millions of Americans currently following diets to decrease body weight and risk for CVD. ..
  61. SURGERY AND INTESTINAL ADAPTATION
    Stanley Ashley; Fiscal Year: 2005
    ..We anticipate that the results of these studies will provide a basis for further clinical trials designed to test the therapeutic potential of GLP-2 in human disease. ..