liver transplantation

Summary

Summary: The transference of a part of or an entire liver from one human or animal to another.

Top Publications

  1. ncbi Liver transplantation for hepatocellular carcinoma
    H Bismuth
    Centre Hepatobiliaire, Universite Paris Sud, Hopital Paul Brousse, Villejuif, France
    Semin Liver Dis 19:311-22. 1999
  2. ncbi Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival
    F Y Yao
    Department of Medicine, University of California, San Francisco 94143 0538, USA
    Hepatology 33:1394-403. 2001
  3. ncbi Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
    Zhe Yang
    Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Zhejiang, China
    Ann Surg Oncol 18:1243-50. 2011
  4. ncbi Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation
    Ming Chun Lai
    Department of Hepatobiliary and Pancreatic Surgery, Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, People s Republic of China
    Med Oncol 29:1810-6. 2012
  5. ncbi The model for end-stage liver disease (MELD)
    Patrick S Kamath
    Advanced Liver Disease Study Group, Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 45:797-805. 2007
  6. ncbi Hyponatremia and mortality among patients on the liver-transplant waiting list
    W Ray Kim
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 359:1018-26. 2008
  7. ncbi Evidence-based incorporation of serum sodium concentration into MELD
    Scott W Biggins
    University of California San Francisco, San Francisco, California, USA
    Gastroenterology 130:1652-60. 2006
  8. ncbi Liver transplantation for hepatocellular carcinoma: Hangzhou experiences
    Shu Sen Zheng
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
    Transplantation 85:1726-32. 2008
  9. ncbi Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment
    Takashi Motomura
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Hepatol 58:58-64. 2013
  10. ncbi Model for end-stage liver disease (MELD) and allocation of donor livers
    Russell Wiesner
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gastroenterology 124:91-6. 2003

Detail Information

Publications368 found, 100 shown here

  1. ncbi Liver transplantation for hepatocellular carcinoma
    H Bismuth
    Centre Hepatobiliaire, Universite Paris Sud, Hopital Paul Brousse, Villejuif, France
    Semin Liver Dis 19:311-22. 1999
    b>Liver transplantation for hepatocellular carcinoma (HCC) in patients with cirrhosis is a radical treatment of the tumor and associated precancerous state. It is potentially curative in a proportion of patients...
  2. ncbi Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival
    F Y Yao
    Department of Medicine, University of California, San Francisco 94143 0538, USA
    Hepatology 33:1394-403. 2001
    ..carcinoma (HCC) based on the size and number of lesions that predict recurrence after orthotopic liver transplantation (OLT) has not been clearly established...
  3. ncbi Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
    Zhe Yang
    Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Zhejiang, China
    Ann Surg Oncol 18:1243-50. 2011
    ..The aim of the present study is to examine the expression pattern of HOTAIR in hepatocellular carcinoma (HCC) and its clinical significance as well as its biological role in tumor progression...
  4. ncbi Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation
    Ming Chun Lai
    Department of Hepatobiliary and Pancreatic Surgery, Key Lab of Combined Multi Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, People s Republic of China
    Med Oncol 29:1810-6. 2012
    ..quantitative real-time PCR in 9 liver cancer cell lines and 112 HCC cases including 60 cases who received liver transplantation (LT) with complete follow-up data...
  5. ncbi The model for end-stage liver disease (MELD)
    Patrick S Kamath
    Advanced Liver Disease Study Group, Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 45:797-805. 2007
    ..The major use of the MELD score has been in allocation of organs for liver transplantation. However, the MELD score has also been shown to predict survival in patients with cirrhosis who have ..
  6. ncbi Hyponatremia and mortality among patients on the liver-transplant waiting list
    W Ray Kim
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 359:1018-26. 2008
    ..Under the current liver-transplantation policy, donor organs are offered to patients with the highest risk of death...
  7. ncbi Evidence-based incorporation of serum sodium concentration into MELD
    Scott W Biggins
    University of California San Francisco, San Francisco, California, USA
    Gastroenterology 130:1652-60. 2006
    Serum sodium (Na) concentrations have been suggested as a useful predictor of mortality in patients with end-stage liver disease awaiting liver transplantation.
  8. ncbi Liver transplantation for hepatocellular carcinoma: Hangzhou experiences
    Shu Sen Zheng
    Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People s Republic of China
    Transplantation 85:1726-32. 2008
    b>Liver transplantation (LT) has been the treatment of choice for patients with hepatocellular carcinoma (HCC)...
  9. ncbi Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment
    Takashi Motomura
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Hepatol 58:58-64. 2013
    Although the Milan criteria (MC) have been used to select liver transplantation candidates among patients with hepatocellular carcinoma (HCC), many patients exceeding the MC have shown good prognosis...
  10. ncbi Model for end-stage liver disease (MELD) and allocation of donor livers
    Russell Wiesner
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gastroenterology 124:91-6. 2003
    ..Our aim was to assess the capability of the Model for End-Stage Liver Disease (MELD) score to correctly rank potential liver recipients according to their severity of liver disease and mortality risk on the OPTN liver waiting list...
  11. ncbi Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation
    Waqar R R Farid
    Department of Surgery and Laboratory of Experimental Transplantation and Intestinal Surgery, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Liver Transpl 18:290-7. 2012
    ..Their usefulness in human liver transplantation, however, has not been addressed...
  12. ncbi Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning
    Hartmut Jaeschke
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Am J Physiol Gastrointest Liver Physiol 284:G15-26. 2003
    ..part, responsible for the morbidity associated with liver surgery under total vascular exclusion or after liver transplantation. The pathophysiology of hepatic ischemia-reperfusion includes a number of mechanisms that contribute to ..
  13. ncbi Resection and liver transplantation for hepatocellular carcinoma
    Josep M Llovet
    BCLC Group, Liver Unit, Digestive Disease Institute, IDIBAPS, Hospital Clinic, University of Barcelona, Catalonia, Spain
    Semin Liver Dis 25:181-200. 2005
    ..b>Liver transplantation provides excellent outcomes applying the Milan criteria (single nodule < or = 5 cm or two or three ..
  14. ncbi Relationship between the interleukin-28b gene polymorphism and the histological severity of hepatitis C virus-induced graft inflammation and the response to antiviral therapy after liver transplantation
    Dennis Eurich
    Department of General, Visceral, and Transplant Surgery, Charite, Campus Virchow, Berlin, Germany
    Liver Transpl 17:289-98. 2011
    Up to 30% of liver transplants will develop graft cirrhosis within 5 years after liver transplantation (LT) due to recurrent HCV-infection forwarding accelerated graft damage...
  15. ncbi Viral hepatitis in liver transplantation
    Gonzalo Crespo
    Liver Unit, Hospital Clinic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Gastroenterology 142:1373-1383.e1. 2012
    b>Liver transplantation is the only alternative for patients with end-stage liver disease...
  16. ncbi Identification of recurrence-related microRNAs in hepatocellular carcinoma following liver transplantation
    Zhong Bo Han
    Department of General Surgery, Shanghai First People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China
    Mol Oncol 6:445-57. 2012
    Tumor recurrence-related microRNAs (miRNAs) in hepatocellular carcinoma (HCC) following orthotopic liver transplantation (OLT) are not clear yet...
  17. ncbi Novel advancements in the management of hepatocellular carcinoma in 2008
    Josep M Llovet
    Barcelona Clinic Liver Cancer BCLC Group, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, CIBERehd, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    J Hepatol 48:S20-37. 2008
    ..Now, the research effort faces other areas of unmet need, such as the adjuvant setting of resection/local ablation and combination therapies...
  18. ncbi Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis
    Vincenzo Mazzaferro
    National Cancer Institute, Milan, Italy
    Lancet Oncol 10:35-43. 2009
    Patients undergoing liver transplantation for hepatocellular carcinoma within the Milan criteria (single tumour </=5 cm in size or </=3 tumours each </=3 cm in size, and no macrovascular invasion) have an excellent outcome...
  19. ncbi Current strategy for staging and treatment: the BCLC update and future prospects
    Alejandro Forner
    Barcelona Clinic Liver Cancer BCLC Group, Liver Unit, ICMDM, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Semin Liver Dis 30:61-74. 2010
    ..Finally, patients at end-stage should merely receive palliative care...
  20. ncbi Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma
    Karim J Halazun
    Department of Organ Transplantation, New York Presbyterian Hospital, Columbia University, MHB 7GS 313, 177 Ft Washington Avenue, New York, NY 10032, USA
    Ann Surg 250:141-51. 2009
    ..to preoperatively assess outcome in patients with hepatocellular carcinoma (HCC) who receive orthotopic liver transplantation (OLT)...
  21. pmc A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation
    Guo Ying Wang
    Liver Transplantation Center, Third Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    PLoS ONE 6:e25295. 2011
    ..However, the cut-off values are empirical. We determined the optimal cut-off value to predict HCC recurrence after liver transplantation (LT) and further established a scoring model based on NLR.
  22. pmc Hepatitis C virus-infected women have a higher risk of advanced fibrosis and graft loss after liver transplantation than men
    Jennifer C Lai
    Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA 94143, USA
    Hepatology 54:418-24. 2011
    ..30; 95% CI, 1.01-1.67; P=0.04) and graft loss (HR, 1.31; 95% CI, 1.02-1.67; P=0.03)...
  23. ncbi Up-regulation of microRNA-155 promotes cancer cell invasion and predicts poor survival of hepatocellular carcinoma following liver transplantation
    Zhong Bo Han
    Department of General Surgery, Shanghai First People s Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China
    J Cancer Res Clin Oncol 138:153-61. 2012
    ..The aim of this study was to determine whether altered microRNA-155 expression is associated with hepatocellular carcinoma (HCC) recurrence and prognosis following orthotopic liver transplantation (OLT).
  24. pmc The significance of donor-specific HLA antibodies in rejection and ductopenia development in ABO compatible liver transplantation
    A I Musat
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Transplant 11:500-10. 2011
    The role of humoral alloreactivity in ABO-compatible liver transplantation remains unclear...
  25. pmc Urinary neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury after orthotopic liver transplantation
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Nephrol Dial Transplant 26:1717-23. 2011
    ..It predicts acute kidney injury (AKI) in multiple clinical scenarios. We hypothesized that urinary NGAL can predict AKI after liver transplantation.
  26. ncbi A practical guide to the management of HCV infection following liver transplantation
    K Watt
    Department of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, USA
    Am J Transplant 9:1707-13. 2009
    Hepatitis C-associated liver failure is the most common indication for liver transplantation, with virological recurrence near ubiquitous...
  27. pmc Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report
    Pierre Alain Clavien
    Department of Surgery, Swiss HPB and Transplant Centers, University Hospital Zurich, Zurich, Switzerland
    Lancet Oncol 13:e11-22. 2012
    Although liver transplantation is a widely accepted treatment for hepatocellular carcinoma (HCC), much controversy remains and there is no generally accepted set of guidelines...
  28. pmc Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation
    Samira Fafi-Kremer
    Institut National de la Sante et de la Recherche Medicale, Unité 748, Strasbourg, France
    J Exp Med 207:2019-31. 2010
    End-stage liver disease caused by chronic hepatitis C virus (HCV) infection is a leading cause for liver transplantation (LT)...
  29. ncbi Characteristics associated with liver graft failure: the concept of a donor risk index
    S Feng
    Department of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, California, USA
    Am J Transplant 6:783-90. 2006
    ..physicians and candidates have become increasingly aware that donor characteristics significantly impact liver transplantation outcomes...
  30. ncbi Liver transplantation in the United States, 1999-2008
    P J Thuluvath
    Mercy Medical Center, Baltimore, MD, USA
    Am J Transplant 10:1003-19. 2010
    ..The current status of liver transplantation in the United States between 1999 and 2008 was analyzed using SRTR data...
  31. ncbi Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation
    Bert Jan F de Rooij
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Hepatology 52:1100-10. 2010
    Infectious complications after orthotopic liver transplantation (OLT) are a major clinical problem. The lectin pathway of complement activation is liver-derived and a crucial effector of the innate immune defense against pathogens...
  32. ncbi Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States
    Michael R Charlton
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 141:1249-53. 2011
    The relative frequency of nonalcoholic steatohepatitis (NASH) as an indication for liver transplantation and comparative outcomes following transplantation are poorly understood.
  33. ncbi Toward optimizing the indications for orthotopic liver transplantation in hepatocellular carcinoma
    Didier Samuel
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Liver Transpl 17:S6-13. 2011
    1. Liver transplantation is currently an effective therapy for patients with HCC who meet the Milan criteria. 2...
  34. ncbi De novo internal neoplasms after liver transplantation: increased risk and aggressive behavior in recent years?
    Salvador Benlloch
    Department of Hepato Gastroenterology, Hospital Universitario La Fe, Valencia, Spain
    Am J Transplant 4:596-604. 2004
    The goal of the study was to determine the incidence and variables associated with post-liver transplantation (LT) de novo internal neoplasms development, excluding skin tumors and hepatocellular carcinoma...
  35. pmc Association of MDR1 gene SNPs and haplotypes with the tacrolimus dose requirements in Han Chinese liver transplant recipients
    Xiaobo Yu
    Key Lab of Combined Multi Organ Transplantation, The First Affiliated Hospital, School of Medicine, Zhejiang University, Ministry of Public Health, Hangzhou, Zhejiang, China
    PLoS ONE 6:e25933. 2011
    ....
  36. ncbi Should possible recurrence of disease contraindicate liver transplantation in patients with end-stage alveolar echinococcosis? A 20-year follow-up study
    Solange Bresson-Hadni
    World Health Organization Collaborating Centre for Prevention and Treatment of Human Echinococcosis, University Hospital and University of Franche Comté, Besancon, France
    Liver Transpl 17:855-65. 2011
    b>Liver transplantation (LT) is currently contraindicated in patients with residual or metastatic alveolar echinococcosis (AE) lesions...
  37. pmc Interleukin-28B polymorphisms are associated with histological recurrence and treatment response following liver transplantation in patients with hepatitis C virus infection
    Michael R Charlton
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Hepatology 53:317-24. 2011
    ..The cohort study included 189 consecutive patients infected with hepatitis C virus (HCV) who underwent liver transplantation between January 1, 1995, and January 1, 2005, at the Mayo Clinic, Rochester, MN...
  38. ncbi Preformed antibodies detected by cytotoxic assay or multibead array decrease liver allograft survival: role of human leukocyte antigen compatibility
    Marcela Castillo-Rama
    Department of Immunology, Hospital Doce de Octubre, Madrid, Spain
    Liver Transpl 14:554-62. 2008
    The significance of human leukocyte antigen (HLA) compatibility and preformed antibodies in liver transplantation remains unclear...
  39. ncbi West Nile virus encephalitis acquired via liver transplantation and clinical response to intravenous immunoglobulin: case report and review of the literature
    C Rhee
    Department of Internal Medicine, Stanford University School of Medicine, Palo Alto, California, USA
    Transpl Infect Dis 13:312-7. 2011
    ..We review previous cases of organ-transmitted WNV, the use of IVIg for WNV encephalitis, and the issue of organ donor screening...
  40. ncbi Donor mannose-binding lectin deficiency increases the likelihood of clinically significant infection after liver transplantation
    Daniel L Worthley
    RBWH Foundation Clinical Research Centre, Royal Brisbane and Women s Hospital and Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Clin Infect Dis 48:410-7. 2009
    ..We report a large, retrospective study that examined the association between MBL status and clinically significant infection following orthotopic liver transplantation.
  41. ncbi De novo malignancies after liver transplantation: a major cause of late death
    J J Fung
    Division of Transplantation Surgery, the Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Liver Transpl 7:S109-18. 2001
    ..5. An increased incidence of de novo cancers in chronically immunocompromised liver transplant recipients demands careful long-term screening protocols to help facilitate diagnosis at an earlier stage of disease...
  42. pmc Human monoclonal antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study
    R T Chung
    Department of Transplant Surgery, Massachusetts General Hospital, Boston, MA, USA
    Am J Transplant 13:1047-54. 2013
    Rapid allograft infection complicates liver transplantation (LT) in patients with hepatitis C virus (HCV). Pegylated interferon-α and ribavirin therapy after LT has significant toxicity and limited efficacy...
  43. ncbi Increased cancer risk after liver transplantation: a population-based study
    E B Haagsma
    Department of Gastroenterology and Hepatology, University Hospital Groningen, The Netherlands
    J Hepatol 34:84-91. 2001
    Development of de novo malignancies emerges as a serious long term complication after liver transplantation.
  44. ncbi The association between hepatitis C infection and survival after orthotopic liver transplantation
    Lisa M Forman
    Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 122:889-96. 2002
    The effect of hepatitis C viral (HCV) infection on patient and allograft survival after orthotopic liver transplantation is controversial...
  45. pmc Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts
    Christopher D Anderson
    Departments of Surgery, Washington University, St Louis, MO 63110, USA
    Liver Transpl 17:189-200. 2011
    Hepatic steatosis continues to present a major challenge in liver transplantation. These organs have been shown to have increased susceptibility to cold ischemia/reperfusion (CIR) injury in comparison with otherwise comparable lean ..
  46. ncbi Stroke volume variation derived by arterial pulse contour analysis is a good indicator for preload estimation during liver transplantation
    B C Su
    Department of Anesthesia, Chang Gung Memorial Hospital Linkou, and College of Medicine, Chang Gung University, Kwei Shan Taoyuan, Taiwan, People s Republic of China
    Transplant Proc 44:429-32. 2012
    Accurate determination of preload during liver transplantation is essential...
  47. pmc MELD score and serum sodium in the prediction of survival of patients with cirrhosis awaiting liver transplantation
    Maria Carlota Londoño
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Institut de Investigacions Biomèdiques August Pi Sunyer, CIBER de Enfermedades Hepáticas y Digestivas and Centro de Investigaciones Biomédicas Esther Koplowitz, Barcelona, Spain
    Gut 56:1283-90. 2007
    ..was to assess the prognostic value of serum sodium in the prediction of survival at 3 and 12 months after listing in patients with cirrhosis awaiting liver transplantation, and to compare its predictive value with that of the MELD score.
  48. ncbi Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death
    Douglas M Heuman
    Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
    Hepatology 40:802-10. 2004
    Despite the adoption of "sickest first" liver transplantation, pretransplant death remains common, and many early deaths occur despite initially low Model for End-stage Liver Disease (MELD) scores...
  49. ncbi Experimental and clinical significance of antinuclear antibodies in liver transplantation
    Toshiaki Nakano
    Department of Surgery, Liver Transplantation Program, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Transplantation 83:1122-5. 2007
    ..present study, we aimed to evaluate the immunological role of antinuclear Abs in experimental and clinical liver transplantation. In a rat tolerogenic orthotopic liver transplantation (OLT) model, antihistone H1 and HMGB1 titers were ..
  50. ncbi Neuroendocrine tumors metastatic to the liver: how to select patients for liver transplantation?
    Vincenzo Mazzaferro
    Gastrointestinal Surgery and Liver Transplantation Unit, National Cancer Institute, Istituto Nazionale Tumori Fondazione IRCCS, Via Venezian 1, Milan 20133, Italy
    J Hepatol 47:460-6. 2007
  51. ncbi Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999
    ..Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells...
  52. ncbi MELD score and clinical type predict prognosis in hepatorenal syndrome: relevance to liver transplantation
    Carlo Alessandria
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Hepatology 41:1282-9. 2005
    ..These data can be useful in the management of patients with HRS, particularly for patients who are candidates for liver transplantation.
  53. ncbi Surgical treatment of hepatocellular carcinoma beyond Milan criteria. Results of liver resection, salvage transplantation, and primary liver transplantation
    Marcelo E Facciuto
    Liver Transplant and Hepatobiliary Service, Westchester Medical Center, New York Medical College, 95 Grasslands Road, Valhalla, New York 10595, USA
    Ann Surg Oncol 15:1383-91. 2008
    ..There is no clear consensus regarding the best treatment strategy for patients with advanced hepatocellular carcinoma (HCC)...
  54. ncbi Effect of different immunosuppressive schedules on recurrence-free survival after liver transplantation for hepatocellular carcinoma
    Marco Vivarelli
    Department of Surgery and Transplantation, University of Bologna, S Orsola Hospital, Bologna, Italy
    Transplantation 89:227-31. 2010
    Tumor recurrence represents the main limitation of liver transplantation in patients with hepatocellular carcinoma (HCC) and can be favored by exposure to calcineurin inhibitors.
  55. ncbi Predictors of long-term survival after liver transplantation for metastatic endocrine tumors: an 85-case French multicentric report
    Y P Le Treut
    Department of Surgery, Hopital la Conception, Marseille, France
    Am J Transplant 8:1205-13. 2008
    b>Liver transplantation (LTx) for metastatic endocrine tumors (MET) remains controversial due to the lack of clear selection criteria. From 1989 to 2005, 85 patients underwent LTx for MET...
  56. ncbi Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation
    Lee H Bouwman
    Department of Surgery, Leiden University Medical Center, The Netherlands
    Gastroenterology 129:408-14. 2005
    Infection is the primary cause of death after liver transplantation. Mannose binding lectin (MBL) is a recognition molecule of the lectin pathway of complement and a key component of innate immunity...
  57. ncbi Fatty liver in liver transplantation and surgery
    M Selzner
    Department of Visceral Surgery and Transplantation, , , , Switzerland
    Semin Liver Dis 21:105-13. 2001
    Steatosis of the liver is common in Western countries, affecting about 25% of donors for liver transplantation and 20% of patients undergoing liver resection...
  58. ncbi Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries
    U Baccarani
    Department of Tissue and Organ Transplantation, University Hospital of Udine, Italy
    Dig Liver Dis 42:55-60. 2010
    ..The purpose of this study is to describe de novo post-liver transplant malignancies and compare their frequency with incidence rates from Italian cancer registries...
  59. ncbi Hepatic ischemia/reperfusion injury--a fresh look
    Constantino Fondevila
    Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Exp Mol Pathol 74:86-93. 2003
    Ischemia/reperfusion (I/R) injury is a multifactorial process that affects graft function after liver transplantation. An understanding of the mechanisms involved in I/R injury is essential for the design of therapeutic strategies to ..
  60. pmc Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: a multicenter study of 412 patients
    Thomas Decaens
    Service d hépatologie et de gastroentérologie, AP HP, Hopital Henri Mondor, Creteil, Unite INSERM 581, France
    World J Gastroenterol 12:7319-25. 2006
    To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or controlled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver ..
  61. ncbi Plasma microRNA, a potential biomarker for acute rejection after liver transplantation
    Jie Hu
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion Fudan University, the Chinese Ministry of Education, and Shanghai Key Laboratory for Organ Transplantation, Shanghai, PR China
    Transplantation 95:991-9. 2013
    ..Acute rejection (AR) of an organ transplant is a life-threatening complication. Currently, there are few diagnostic biomarkers suitable for clinical application. We aim to determine the potential of plasma microRNAs as biomarkers for AR...
  62. ncbi Liver transplantation using fatty livers: always feasible?
    Lucas McCormack
    Hepatobiliary Surgery and Liver Transplant Unit, Hospital Aleman of Buenos Aires, Buenos Aires, Argentina
    J Hepatol 54:1055-62. 2011
    ..significantly to the inconsistent results of studies reporting on graft steatosis and the outcome of liver transplantation. In this review, various definitions, prevalence and methods of quantification of liver steatosis will be ..
  63. ncbi Positive lymphocytotoxic crossmatch does not adversely affect survival in living donor liver transplantation
    Yasuhiko Sugawara
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Dig Surg 26:482-6. 2009
    The influence of lymphocytotoxic crossmatch on survival or acute rejection in liver transplantation remains controversial. Data regarding graft survival and acute rejection of living donor liver transplantation (LDLT) are limited.
  64. ncbi Parenteral nutrition-associated liver disease and the role for isolated intestine and intestine/liver transplantation
    Alan L Buchman
    Division of Gastroenterology, Northwestern Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Hepatology 43:9-19. 2006
    ..If these interventions fail, intestinal transplantation should be performed expeditiously before development of ESLD mandates simultaneous inclusion of a liver graft as well...
  65. ncbi Acute kidney injury following liver transplantation: definition and outcome
    Yousri M Barri
    Baylor Regional Transplant Institute, Dallas, TX 75246, USA
    Liver Transpl 15:475-83. 2009
    The incidence of acute kidney injury (AKI) has been reported to vary between 17% and 95% post-orthotopic liver transplantation. This variability may be related to the absence of a uniform definition of AKI in this setting...
  66. ncbi Comparison between living donor liver transplantation recipients who met the Milan and UCSF criteria after successful downstaging therapies
    Jy Lei
    Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, China
    J Gastrointest Surg 16:2120-5. 2012
    ..downstaging therapies were introduced to liver recipients who could not meet the relative criteria for liver transplantation, and many endpoints were reported...
  67. ncbi Living vs. deceased donor liver transplantation for hepatocellular carcinoma: a systematic review and meta-analysis
    Robert C Grant
    Department of Surgery, University of Toronto, Toronto, ON, Canada
    Clin Transplant 27:140-7. 2013
    ..However, clinical studies report conflicting results comparing living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) for HCC...
  68. ncbi Diagnosis and management of alcoholic liver disease
    Arthur J McCullough
    Department of Gastroenterology and Hepatology and The Digestive Disease Institute and the Cleveland Clinic Lerner College of Medicine at Case Western University, Cleveland, Ohio 44195, USA
    J Dig Dis 12:257-62. 2011
    ..Patients with endstage liver disease should be considered for liver transplantation. Six months of abstinence is considered to be a requirement prior to transplant, but this length of time ..
  69. ncbi Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants
    Sandy Feng
    Division of Transplantation, Department of Surgery, University of California, San Francisco, CA 94143, USA
    JAMA 307:283-93. 2012
    Although life-saving, liver transplantation burdens children with lifelong immunosuppression and substantial potential for morbidity and mortality.
  70. ncbi Progressive histological damage in liver allografts following pediatric liver transplantation
    Helen M Evans
    Liver Unit, Birmingham Children s Hospital, Birmingham, United Kingdom
    Hepatology 43:1109-17. 2006
    The long-term histological outcome after pediatric liver transplantation (OLT) is not yet fully understood...
  71. ncbi Liver regeneration in donors and adult recipients after living donor liver transplantation
    Junko Haga
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Liver Transpl 14:1718-24. 2008
    In living donor liver transplantation, the safety of the donor operation is the highest priority. The introduction of the right lobe graft was late because of concerns about donor safety...
  72. ncbi Evolving frequency and outcomes of liver transplantation based on etiology of liver disease
    Ashwani K Singal
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Transplantation 95:755-60. 2013
    ..for specific liver diseases and listing of nonalcoholic steatohepatitis (NASH) as an etiology for liver transplantation (LT), data are unclear on the impact of disease etiology on the frequency of LT and liver ..
  73. ncbi Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection
    Christian M Lange
    Medizinische Klinik 1, Klinikum der J W Goethe Universität Frankfurt am Main, D 60590 Frankfurt am Main, Germany
    J Hepatol 55:322-7. 2011
    ..We therefore, aimed to explore the impact of donor and recipient genotypes of these polymorphisms on hepatitis C virus (HCV) liver graft reinfection...
  74. ncbi Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival
    Frederike G I van Vilsteren
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Liver Transpl 12:448-56. 2006
    b>Liver transplantation for gastroenteropancreatic neuroendocrine cancer (GEP) is controversial. The aim of this study was to assess patient outcomes after liver transplantation for hepatic metastases from GEP...
  75. pmc Robotic liver resection as a bridge to liver transplantation
    Fabrizio Panaro
    Centre de Chirurgie Viscerale et de Transplantation, Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    JSLS 15:86-9. 2011
    ..Robotic surgery for hepatic resection has not yet been extensively reported. The aim of this article is to report the first known case of liver resection with the use of a robot in France...
  76. ncbi Robot-assisted right lobe donor hepatectomy
    Pier Cristoforo Giulianotti
    Division of Minimally Invasive, General Surgery and Robotic Surgery, University of Illinois at Chicago, Chicago, IL, USA
    Transpl Int 25:e5-9. 2012
    ..To our knowledge, this is the first case reported in the literature. The technical feasibility of this minimally invasive approach is demonstrated, exemplifying the novel exciting opportunities offered by robotic technology...
  77. pmc The impact of sirolimus on hepatitis C recurrence after liver transplantation
    Sonal Asthana
    Department of Surgery, University of Alberta, Edmonton, Alberta
    Can J Gastroenterol 25:28-34. 2011
    While some immunosuppression strategies may accelerate hepatitis C virus (HCV) recurrence after liver transplantation (LT), the impact of sirolimus (SRL) is not known.
  78. ncbi High viremia, prolonged Lamivudine therapy and recurrent hepatocellular carcinoma predict posttransplant hepatitis B recurrence
    J Chun
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Korea
    Am J Transplant 10:1649-59. 2010
    Hepatitis B virus (HBV) recurrence following orthotopic liver transplantation (OLT) is generally preventable by prophylaxis with hepatitis B immunoglobulin (HBIG) and lamivudine (LAM)...
  79. ncbi Outcomes of neoadjuvant transarterial chemoembolization to downstage hepatocellular carcinoma before liver transplantation
    William C Chapman
    Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Surg 248:617-25. 2008
    ....
  80. ncbi Ischemic cholangiopathy after controlled donation after cardiac death liver transplantation: a meta-analysis
    Colleen L Jay
    Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Ann Surg 253:259-64. 2011
    ..a meta-analysis to enhance understanding of the risks of biliary complications, particularly ischemic cholangiopathy (IC), after donation after cardiac death (DCD) compared with donation after brain death (DBD) liver transplantation.
  81. ncbi Temporary placement of partially covered self-expandable metal stents for anastomotic biliary strictures after liver transplantation: a prospective, multicenter study
    Ulriikka Chaput
    Hepato Gastroenterology Department, Hopital Cochin, Paris Descartes University, Paris, France
    Gastrointest Endosc 72:1167-74. 2010
    Management of anastomotic biliary strictures after liver transplantation deserves optimization.
  82. ncbi Meta-analysis of performance of Kings's College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure
    Mark J W McPhail
    Liver Intensive Therapy Unit, Institute of Liver Studies, Kings College Hospital, London SE5 9RS, UK
    J Hepatol 53:492-9. 2010
    Current techniques for predicting outcome and requirement for emergency liver transplantation (ELT) in acute liver failure (ALF) are imperfect, though The Kings College Criteria (KCC) are the most commonly applied tools for this purpose...
  83. ncbi Effect of calcineurin inhibitors in the outcome of liver transplantation in hepatitis C virus-positive recipients
    Marina Berenguer
    Hospital Universitari La Fe, Avda Campanar, Valencia, Spain
    Transplantation 90:1204-9. 2010
    ..There is a paucity of good studies evaluating the impact of calcineurin inhibitors on posttransplantation outcome in hepatitis C virus (HCV)-infected liver transplant (LT) recipients...
  84. ncbi Factors influencing renal function after liver transplantation. Results from the MOST, an international observational study
    P Burra
    Gastroenterology, Department of Surgical and Gastroenterological Sciences, University Hospital Padova, Padova, Italy
    Dig Liver Dis 41:350-6. 2009
    Renal failure, both acute and chronic, is a common complication after liver transplantation and can seriously jeopardise long-term outcome...
  85. ncbi Sorafenib as adjuvant therapy for high-risk hepatocellular carcinoma in liver transplant recipients: feasibility and efficacy
    Sammy Saab
    Departments of Medicine, The University of California at Los Angeles, Los Angeles, CA, USA
    Exp Clin Transplant 8:307-13. 2010
    ..Liver transplant can be a definitive treatment for hepatocellular carcinoma. However, recurrence limits long-term survival. Sorafenib is the first agent to improve survival for patients with advanced hepatocellular carcinoma...
  86. pmc PHOENIX: A randomized controlled trial of peginterferon alfa-2a plus ribavirin as a prophylactic treatment after liver transplantation for hepatitis C virus
    Natalie Bzowej
    California Pacific Medical Center, San Francisco, CA, USA
    Liver Transpl 17:528-38. 2011
    The efficacy, tolerability, and safety of the prophylactic treatment of hepatitis C virus (HCV) after liver transplantation (LT) with peginterferon alfa-2a and ribavirin are not known...
  87. ncbi Burden of liver disease in the United States: summary of a workshop
    W Ray Kim
    Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Hepatology 36:227-42. 2002
  88. ncbi Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation--a randomized, double-blind trial
    Nada Rayes
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Am J Transplant 5:125-30. 2005
    Bacterial infections frequently occur early after liver transplantation. We recently reported significant progress with a synbiotic composition, consisting of one lactic acid bacteria (LAB) and one fiber, which reduced the infection rate ..
  89. ncbi Determination of IL28B polymorphisms in liver biopsies obtained after liver transplantation
    Mairene Coto-Llerena
    Liver Unit, Hospital Clinic, CIBERehd, IDIBAPS, Barcelona, Spain
    J Hepatol 56:355-8. 2012
    ..donor IL28B polymorphisms seem to play an important role in the response to hepatitis C treatment after liver transplantation (LT)...
  90. ncbi Covered metal stents for the treatment of biliary complications after orthotopic liver transplantation
    F García-Pajares
    Gastroenterology Service, Liver Transplantation Unit, Rio Hortega Hospital, Valladolid, Spain
    Transplant Proc 42:2966-9. 2010
    Biliary complications, a major source of morbidity after orthotopic liver transplantation (OLT), are increasingly being treated by endoscopic retrograde cholangiopancreatography (ERCP)...
  91. ncbi m-TOR inhibitors: what role in liver transplantation?
    Toshiyasu Kawahara
    Division of Transplantation, Department of Surgery, University of Alberta, Canada
    J Hepatol 55:1441-51. 2011
    ..of calcineurin inhibitors (CNIs) led to marked improvements in patient and graft survival after liver transplantation (LTx)...
  92. ncbi Hypothermic machine preservation in human liver transplantation: the first clinical series
    J V Guarrera
    Center for Liver Disease and Transplantation, Department of Surgery, Columbia University Medical Center, New York, NY, USA
    Am J Transplant 10:372-81. 2010
    ..9 +/- 4.7 days vs. 15.3 +/- 4.9 days in the CS group, p = 0.006). HMP of donor livers provided safe and reliable preservation in this pilot case-controlled series. Further multicenter HMP trials are now warranted...
  93. pmc Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation
    Seung H Kang
    Division of Infectious Diseases, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Infect Dis 205:639-46. 2012
    ..homozygosity for TLR2 R753Q SNP is a marker for CMV disease risk, especially for tissue-invasive disease, after liver transplantation. This observation supports the critical role of TLR2 in the pathogenesis of CMV disease in humans.
  94. ncbi Sevoflurane protects against acute kidney injury in a small-size liver transplantation model
    H Y Kong
    Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China
    Am J Nephrol 32:347-55. 2010
    Living donor liver transplantation (LDLT) patients run the risk of developing acute kidney injury (AKI) and subsequent chronic kidney disease, affecting morbidity and mortality...
  95. ncbi Liver transplantation for hepatocellular carcinoma: comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria
    Francis Y Yao
    Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0538, USA
    Liver Transpl 8:765-74. 2002
    We previously proposed modified staging criteria for predicting acceptable outcome after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). These were solitary tumor < or = 6...
  96. ncbi Hepatitis C virus treatment pre- and post-liver transplantation
    Bruno Roche
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France France
    Liver Int 32:120-8. 2012
    Liver disease caused by the hepatitis C virus is the main indication for liver transplantation in Western countries...
  97. ncbi Antiviral therapy increases the risk of bacterial infections in HCV-infected cirrhotic patients awaiting liver transplantation: A retrospective study
    José A Carrión
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Ciberehd and IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 50:719-28. 2009
    Recurrence of hepatitis C after liver transplantation (LT) is universal and may cause premature graft loss. We evaluated the efficacy and safety of antiviral therapy in HCV-infected patients with decompensated cirrhosis awaiting LT.
  98. ncbi Surgical treatment of Klatskin tumor: liver resection versus transplantation
    Gernot M Kaiser
    Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Hepatogastroenterology 57:1337-40. 2010
    Our objective was to evaluate liver transplantation as a treatment option for Klatskin tumor. Results for transplanted patients suffering from hilar cholangiocarcinoma were therefore compared to patients after hemihepatectomy.
  99. ncbi The significance of acute phase small-for-size graft injury on tumor growth and invasiveness after liver transplantation
    Kwan Man
    Departments of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg 247:1049-57. 2008
    To test the hypothesis that acute phase small-for-size graft injury may promote late phase tumor recurrence after liver transplantation.
  100. ncbi Inaccuracies of creatinine and creatinine-based equations in candidates for liver transplantation with low creatinine: impact on the model for end-stage liver disease score
    Claire Francoz
    Hepatology and Liver Intensive Care Unit, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3
    Liver Transpl 16:1169-77. 2010
    ..True GFR seems to have a better prognostic value than creatinine and creatinine-based equations. Specific equations are needed in patients with cirrhosis to improve prognostic scores...
  101. ncbi Early liver transplantation for severe alcoholic hepatitis
    Philippe Mathurin
    Hopital Claude Huriez, Services Maladies de l Appareil Digestif and INSERM Unité 995, Centre Hospitalier Universitaire, de Lille and Université Nord de France, Lille
    N Engl J Med 365:1790-800. 2011
    ..from alcohol is usually required before patients with severe alcoholic hepatitis are considered for liver transplantation. Patients whose hepatitis is not responding to medical therapy have a 6-month survival rate of ..

Research Grants71

  1. Biomarker for liver ischemia/reperfusion-induced injury
    MONIKA OLI; Fiscal Year: 2006
    ..cause of liver failure during multiple trauma, thermal injury, hemorrhagic and septic shock, and liver transplantation, which contributes significantly to multiple organ failure and mortality...
  2. STUDIES OF THE NATURAL HISTORY OF HEPATITIS C IN LIVER
    Robert Carithers; Fiscal Year: 2002
    ..As a consequence, liver failure from chronic hepatitis C has become the leading indication for liver transplantation both in the United States and Europe...
  3. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..with alpha-1-antitrypsin (A1AT) deficiency develop liver fibrosis/cirrhosis many times resulting in liver transplantation, the transgenic mouse model carrying mutant human genes shows an extremely mild phenotype...
  4. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..multi-organ failure caused by complex trauma including blast injury, septic shock, and graft failure after liver transplantation often leading to death of the patient...
  5. LIVER PRESERVATION FOR TRANSPLANTATION
    John J Lemasters; Fiscal Year: 2012
    ..During the previous period of support, we showed that JNK activation occurs after liver transplantation and that pharmacological inhibition of JNK decreases graft injury and improves graft survival...
  6. Heat Shock Protein Synthesis Inhibitor Treatment of Hepatitis C Viral Infection
    SAMUEL WHEELER FRENCH; Fiscal Year: 2013
    ..Hepatitis C virus (HCV) infection has a worldwide prevalence of 3% and is the main entity responsible for liver transplantation in developed countries for treatment of cirrhosis...
  7. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2012
    ..IRP) injury is an important clinical problem, which determines morbidity and mortality after liver transplantation, liver surgery and hemorrhagic or septic shock. IRP injury is an even bigger issue in steatotic livers...
  8. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    ..liver disease (CFLD) negatively impacts the quality of life and survival of CF patients, and may require liver transplantation, however, the pathogenesis of this condition is not well understood...
  9. Detection of Liver Fibrosis Using IVIM Diffusion and DCE MRI in HCV
    Bachir Taouli; Fiscal Year: 2013
    ..and cirrhosis, which may eventually lead to hepatocellular carcinoma and end-stage liver disease requiring liver transplantation. This disease is/will be the source of enormous health care costs and morbidity/mortality...
  10. Deriving hepatocytes from disease specific iPS to treat metabolic liver disorders
    Namita Roy-Chowdhury; Fiscal Year: 2013
    ..by applicant): Hepatocyte transplantation is being developed as a minimally invasive alternative to liver transplantation for patients with liver failure or inherite metabolic disorders...
  11. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..antivirals, are largely ineffective in treating the underlying fibrosis, and in the majority of cases, liver transplantation is the only effective cure...
  12. Hepatocarcinogenesis Secondary to Hepatitis C
    Srikanta Dash; Fiscal Year: 2012
    ..It is the most common cause of liver transplantation. It is now believed that long-standing chronic inflammation secondary to HCV infection is the main cause ..
  13. GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREE
    GIANFRANCO D ALPINI; Fiscal Year: 2010
    ..Cholangiopathies cause morbidity and mortality and are a major public health concern leading to liver transplantation. Cholangiopathies are characterized by cholangiocyte loss requiring the heterogeneous growth of different ..
  14. Biliary Atresia, Cholestatic Liver Diseases, and Cystic Fibrosis: Indiana Univers
    Jean Pappas Molleston; Fiscal Year: 2013
    ..Relevance: Pediatric liver disease, associated with chronic illness, malnutrition, and the need for liver transplantation, has significant public health impact...
  15. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ..These cholangiopathies cause morbidity and mortality and are a major reason for liver transplantation. During the progression of cholangiopathies, proliferation of cholangiocytes is critical for the ..
  16. The Pittsburgh Cholestatic Liver Disease Consortium
    Benjamin L Shneider; Fiscal Year: 2013
    ..cholestasis, lead to significant morbidity and mortality in childhood and frequently necessitate liver transplantation. No single United States clinical center sees a large enough number of patients with these disorders to ..
  17. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
    ..hepatic fibrosis-a reversible condition-that can lead to cirrhosis, hepatocellular carcinoma, and need for liver transplantation. Our preliminary data and the current proposal are consistent with the long-term objectives of this ..
  18. Colorado Center for Childhood Liver Disease Research and Education
    Ronald J Sokol; Fiscal Year: 2013
    ..This study will help to discover new diagnostic tests and treatments for children with liver disease and those who undergo liver transplantation. We will also train the researchers of the future who will study these rare diseases.
  19. MECHANISMS OF LIVER INJURY BY HEPATITIS C AND ALCOHOL
    Steven A Weinman; Fiscal Year: 2013
    ..isoelectric focusing assay for FOXO3 PTMs, examination of liver explants samples from patients undergoing liver transplantation for hepatocellular carcinoma, and cellular and mouse models of HCV-alcohol interactions...
  20. Adipose Organ Transplant for Treatment of Maple Syrup Urine Disease
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2012
    ..Indeed, published studies as well as others underway indicate great promise for elective liver transplantation in MSUD, with many subjects resuming a normal diet...
  21. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
    ..ALF), which has a high mortality and for which therapeutic options are largely limited to an emergency liver transplantation. It is generally believed that ammonia is responsible for the edema in ALF, and that the edema is ..
  22. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..is an obstacle to recovery from liver disease and for patients who receive grafts through living-donor liver transplantation. Improved understanding of the mechanisms that regulate liver regeneration will facilitate the development ..
  23. High-Tc susceptometer to monitor transfusional iron overload (NSR device)
    Gary M Brittenham; Fiscal Year: 2012
    ..results of biochemical analysis of tissue from liver explants from adult and pediatric patients undergoing liver transplantation and from clinically indicated liver biopsy;and (2) to prospectively validate the high-Tc susceptometer ..
  24. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
    ..obstruction of the extrahepatic biliary tree and the most common indication for pediatric liver transplantation worldwide...
  25. Multiple Molecular Mechanisms for Adiponectin Therapy in Hepatic Fibrogenesis
    Frank A Anania; Fiscal Year: 2013
    ..and cellular basis for the development of hepatic fibrosis that can lead to cirrhosis, and need for liver transplantation. Our work in the prior funding period focused on the role of two key adipocytokines-leptin and adiponectin-..
  26. L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicity
    W Ray Kim; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Liver transplantation (LTx) is now well-established as a means of restoring health in patients with liver failure, the 10th leading cause of death in the US...
  27. Aromatase Inhibitors in Pulmonary Vascular Complications of Liver Disease
    Steven M Kawut; Fiscal Year: 2013
    ..no known disease mechanism, limited, non-specific therapies, and may greatly complicate, delay, or prevent liver transplantation. Hepatopulmonary syndrome (HPS) is characterized by pulmonary microvascular dilations and impaired gas ..
  28. Development of PAR2 Inhibitors for the Treatment of Nonalcoholic steatohepatitis
    Athan Kuliopulos; Fiscal Year: 2013
    ..b>Liver transplantation is currently the only therapeutic approach for severe NASH or other forms of liver fibrosis with no ..
  29. Heme Oxygenase Polymorphisms and Hepatopulmonary Syndrome
    KARI EVAN ROBERTS; Fiscal Year: 2012
    ..HPS;presence of HPS portends a worse survival for patients with advanced liver disease, with or without liver transplantation. Recent evidence from animal and human HPS implicates abnormal heme oxygenase and carbon monoxide ..
  30. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..patients with Hepatitis C cirrhosis, were decreased to the levels seen in healthy people two weeks after liver transplantation. This data suggests that the levels of circulating EMP may be useful as a biomarker of EC function in ..
  31. Transgenic mouse models of HCV infection and replication
    Jieyun Jiang; Fiscal Year: 2012
    ..HCV- associated end-stage of liver diseases is the leading indication for liver transplantation. Advances on HCV research have been significantly hampered by the lack of a robust cell culture HCV ..
  32. Molecular Determinants of Tumor Progression in A Steatolic Liver Microenvironment
    Harold L Moses; Fiscal Year: 2013
    ..In vivo techniques of bone marrow and liver transplantation are proposed to examine cellular mechanisms of action of these MMPs...
  33. Liver Tissue Engineering Through Three-Dimensional Hepatocyte Culture
    Tammy T Chang; Fiscal Year: 2013
    ..b>Liver transplantation is currently the only treatment for patients with end-stage liver disease (ESLD), which is the 12th ..
  34. Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virus
    Charles M Rice; Fiscal Year: 2013
    ..newly diagnosed hepatocellular carcinomas in the United States and is currently the leading indicator for liver transplantation worldwide...
  35. Functional attributes of CD8+ T cells in recovery of hepatitis C virus infection
    HUGO RAMON ROSEN; Fiscal Year: 2013
    ..HCV is a leading etiology of liver cancer and cause for liver transplantation. Although new therapies have improved the rates of sustained response, a large proportion of patients (~50%..
  36. Estrogen signaling in portopulmonary hypertension
    Steven M Kawut; Fiscal Year: 2013
    ..PPHTN is found in ~6% of patients evaluated for liver transplantation (totaling almost 170,000 Americans with PPHTN) and significantly increases mortality...
  37. Regulation of hepcidin and iron metabolism in liver disease
    Julia Goodnough; Fiscal Year: 2011
    ..hepatic disease in the United States: CHC is the leading cause of cirrhosis, hepatocellular carcinoma, and liver transplantation. It is increasingly evident that liver iron loading is a significant contributive factor in the ..
  38. Novel prognostic microRNA biomarkers for primary sclerosing cholangitis
    Kris Kowdley; Fiscal Year: 2013
    ..Without an effective therapeutic option, liver transplantation is currently considered the only curative option for PSC and results an excellent 5 year survival rate of ..
  39. Immunologic dysfunction in biliary atresia
    Jorge A Bezerra; Fiscal Year: 2013
    ..is the most common cause of end-stage cirrhosis in children and the number one indication for pediatric liver transplantation. It results from an inflammatory and fibrosing obstruction of extrahepatic bile ducts that presents as ..
  40. Access to Liver Transplantation for Patients with Primary Sclerosing Cholangitis
    David Seth Goldberg; Fiscal Year: 2011
    ..PSC) is a chronic liver disease that has no treatment and is an otherwise fatal disease without liver transplantation. Patients with PSC face unique complications as compared to other patients with end-stage liver disease, ..
  41. T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    CARA LYNN MACK; Fiscal Year: 2011
    ..Intrahepatic biliary inflammation and sclerosis progresses in most patients with the resulting need for liver transplantation in 80% of patients, accounting for half of all pediatric liver transplants...
  42. Underlying Mechanisms of ApoE in HCV Infection and Assembly
    GUANGXIANG GEORGE LUO; Fiscal Year: 2013
    ..HCV infection is the most common indication for liver transplantation in the United States...
  43. MR Spectroscopy to Evaluate Liver Repopulation by Transplanted Hepatocytes
    Chandan Guha; Fiscal Year: 2009
    Hepatocyte transplantation (HT) could be an alternative to orthotopic liver transplantation in the treatment of both inherited and acquired liver diseases...
  44. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    ..that interact with maternal immune cells, may have a 'tolerogenic'function in heart, kidney, and liver transplantation, where HLA-G expression is associated with graft survival...
  45. Mechanisms of Liver Failure
    Chandrashekhar R Gandhi; Fiscal Year: 2013
    ..for the "irreversible" ALF are generally known, due to the lack of effective pharmacologic treatment, liver transplantation continues to be the only life-saving choice...
  46. A Novel Therapeutic Approach for Liver Injury
    Xiaoling Qiang; Fiscal Year: 2010
    ..of liver failure after severe trauma, thermal injury, hemorrhagic and septic shock, liver resection, or liver transplantation. Hepatic I/R contributes significantly to multiple organ failure and mortality...
  47. Cost-effective Uses of New Hepatitis C Treatments and their VA Budgetary Impact
    Douglas K Owens; Fiscal Year: 2013
    ..extremely costly to manage, and causes decompensated cirrhosis, hepatocellular carcinoma, and the need for liver transplantation. Standard two-drug HCV treatments are effective in a limited proportion of patients and can cause ..
  48. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2013
    ..This issue is of particular importance in liver transplantation where allografts face substantial ischemic, inflammatory, and immune insults that are further exacerbated ..
  49. Designing a Microenvironment Niche for Liver-Specific Differentiation of hESCs
    Alexander Revzin; Fiscal Year: 2013
    ..Currently, the only established successful treatment for end-stage liver disease is liver transplantation. However, the number of donor livers is severely inadequate and a large fraction of patients with liver ..
  50. Autophagy in liver injury
    Jae Sung Kim; Fiscal Year: 2013
    ..I/R) injury which commonly occurs during liver surgery, trauma, hemorrhagic shock and liver transplantation. Mitochondrial autophagy (mitophagy) is the only cellular process that selectively removes abnormal ..
  51. HO1 AND TLR4 IN LIVER ISCHEMIA/REPERFUSION INJURY IN TRANSPLANT RECIPIENTS
    Jerzy W Kupiec-Weglinski; Fiscal Year: 2013
    Orthotopic liver transplantation (OLT) is an effective therapeutic modality for the treatment of end-stage liver disease...
  52. A20 Gene Polymorphisms in LDLT
    Christiane Ferran; Fiscal Year: 2012
    ..the graft could serve as reliable prognostic markers for liver regeneration and function in living donor liver transplantation (LDLT)...
  53. Rare Liver Disease Network
    Ronald J Sokol; Fiscal Year: 2010
    ..These disorders have serious if not fatal consequences (without liver transplantation) and severely affect the child's normal growth and development...
  54. PDGFR and KDR Inhibitors for Liver Fibrosis
    Bert Oehlen; Fiscal Year: 2010
    ..antivirals, are largely ineffective in treating the underlying fibrosis, and in the majority of cases, liver transplantation is the only effective cure...
  55. DNA methylation in biliary development and disease
    Randolph P Matthews; Fiscal Year: 2013
    ..BA affects 1/10,000 infants and is the leading indication for liver transplantation in children...
  56. Circulating miRNA as a biomarker for biliary atresia
    Joshua R Friedman; Fiscal Year: 2013
    ..Ultimately the majority of patients with biliary atresia will require liver transplantation. s a result, biliary atresia is the most common indication for pediatric liver transplantation in the US ..
  57. Patient-Oriented Research on Hepatitis in Special Populations
    Raymond T Chung; Fiscal Year: 2013
    ..These include patients with HIV coinfection and patients undergoing liver transplantation for HCV and HBV-related complications, both of whom experience accelerated natural history of disease...
  58. Renal and Cardiovascular Events in Patients with Chronic Kidney Disease
    Akinlolu O Ojo; Fiscal Year: 2013
    ..of CKD Patients with Chronic Hepatitis C (HCV) Infection;and (b) The Prevention of Kidney Disease in Liver Transplantation. Aim 3 is to provide mentorship in POR to Dr. Fu Luan and Dr...
  59. Sorafenib for Hepatopulmonary Syndrome
    Steven M Kawut; Fiscal Year: 2013
    ..HPS occurs in 33% of patients evaluated for liver transplantation amounting to hundreds of thousands Americans with HPS...
  60. Bias in Retransplantation Survival Models: Selection Criteria and Hepatitis C
    Scott W Biggins; Fiscal Year: 2011
    ..accomplish the following goals: (1) develop expertise in outcome modeling of end-stage liver disease and liver transplantation;(2) investigate the novel application of marginal structural models (MSM) to enhance the survival benefit ..
  61. Improvement of Liver Transplantation by a Sphingosine Kinase Inhibitor
    Zhi Zhong; Fiscal Year: 2010
    Severe shortages of donor organs limit the use of orthotopic liver transplantation (LT), the only proven therapy for end-stage liver diseases...
  62. Novel therapeutic for Alcoholic Liver Disease
    Bert Oehlen; Fiscal Year: 2009
    ..b>Liver transplantation may be a treatment option of last resort for selected patients...
  63. Effect of Lactoferrin on Alcohol-Induced Dysbiosis and Gut Barrier Dysfunction
    Cynthia Ju; Fiscal Year: 2013
    ..Currently, the only effective treatment option for alcohol-induced liver cirrhosis and cancer is liver transplantation. Therefore, it is imperative to develop new therapeutic strategies...
  64. PROTEIN SYNTHESIS IN NORMAL AND REGENERATING LIVER
    David A Shafritz; Fiscal Year: 2012
    Currently, whole liver transplantation is the primary method used to treat end stage chronic liver failure...
  65. Open-Source Informatics Used to Improve Outcomes in Pediatric Liver Transplants
    STEVEN PETER BUCUVALAS; Fiscal Year: 2010
    ..Some 500 children undergo pediatric liver transplantation (PLT) annually in the U.S...
  66. Serologic test for neonatal hemochromatosis in infants with acute liver failure
    PETER FRANK WHITINGTON; Fiscal Year: 2010
    ..in infants, result in significantly improved outcome with medical therapy, and reduce the utilization of liver transplantation in pediatric patients...
  67. METHODOLOGIC RESEARCH IN SIMULATING COMPLEX DISEASE
    Mark Roberts; Fiscal Year: 1991
    ..and refine new quantitative techniques that will enhance our ability to predict the optimal timing of liver transplantation in end stage liver disease (ESLD)...
  68. RECURRENT HEPATITIS B AFTER LIVER TRANSPLANTATION
    Anna Lok; Fiscal Year: 2007
    Hepatitis B accounts for approximately 5000 deaths/yr in the United States. Early results with orthotopic liver transplantation (OLT) for hepatitis B were poor with recurrence rates of >80% and 2-year mortality rates of 50%...
  69. LIVER TRANSPLANT ASSOCIATED CYTOMEGALOVIRUS PREVENTION
    David Snydman; Fiscal Year: 1991
    Cytomegalovirus (CMV) is the single most significant viral infection complicating liver transplantation. CMV increases the mortality of liver transplant patients and may contribute to complicating fungal or parasitic superinfection...
  70. Cell Culture System for Hepatitis C Virus Genotype 1a
    Adrian Di Bisceglie; Fiscal Year: 2009
    ..Liver disease related to chronic HCV infection is now the leading indication for liver transplantation in the United States...
  71. PILOT STUDY OF PIRFENIDONE IN PBC AND PSC
    Keith Lindor; Fiscal Year: 1999
    ..eventually develop cirrhosis and/or portal hypertension with death caused by hepatic failure unless liver transplantation intervenes. No specific therapy has been proven to be totally effective in these diseases...