hepatectomy

Summary

Summary: Excision of all or part of the liver. (Dorland, 28th ed)

Top Publications

  1. ncbi Liver regeneration
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
    Hepatology 43:S45-53. 2006
  2. ncbi Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    D E Cressman
    Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
    Science 274:1379-83. 1996
  3. pmc Evaluation of 300 minimally invasive liver resections at a single institution: less is more
    Alan J Koffron
    Division of Transplantation, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Surg 246:385-92; discussion 392-4. 2007
  4. ncbi Laparoscopic liver resection: a systematic review
    Luca Vigano
    Department of Digestive and Hepatobiliary Surgery, Hopital Henri Mondor, Universite Paris 12, 51 Avenue du Marechal de Lattre de Tassigny, 94010, Creteil Cedex, France
    J Hepatobiliary Pancreat Surg 16:410-21. 2009
  5. pmc Liver regeneration
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Cell Physiol 213:286-300. 2007
  6. ncbi Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy
    Sheng Xian Yuan
    Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
    Hepatology 56:2231-41. 2012
  7. ncbi Liver regeneration: from myth to mechanism
    Rebecca Taub
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19004, USA
    Nat Rev Mol Cell Biol 5:836-47. 2004
  8. pmc Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma
    R Tung-Ping Poon
    Centre of Liver Diseases, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Surg 232:10-24. 2000
  9. pmc Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases
    Eddie K Abdalla
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg 239:818-25; discussion 825-7. 2004
  10. pmc Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas
    George K Michalopoulos
    University of Pittsburgh, Department of Pathology, School of Medicine, S 410 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Pathol 176:2-13. 2010

Detail Information

Publications307 found, 100 shown here

  1. ncbi Liver regeneration
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
    Hepatology 43:S45-53. 2006
    During liver regeneration after partial hepatectomy, normally quiescent hepatocytes undergo one or two rounds of replication to restore the liver mass by a process of compensatory hyperplasia...
  2. ncbi Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    D E Cressman
    Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
    Science 274:1379-83. 1996
    ....
  3. pmc Evaluation of 300 minimally invasive liver resections at a single institution: less is more
    Alan J Koffron
    Division of Transplantation, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Surg 246:385-92; discussion 392-4. 2007
    ..We present the largest, most comprehensive, single center experience to date of minimally invasive liver resection (MILR)...
  4. ncbi Laparoscopic liver resection: a systematic review
    Luca Vigano
    Department of Digestive and Hepatobiliary Surgery, Hopital Henri Mondor, Universite Paris 12, 51 Avenue du Marechal de Lattre de Tassigny, 94010, Creteil Cedex, France
    J Hepatobiliary Pancreat Surg 16:410-21. 2009
    ..Outcomes of laparoscopic liver resection (LLR) are not clarified. The objective of this article is to depict the state of the art of LLR by means of a systematic review of the literature...
  5. pmc Liver regeneration
    George K Michalopoulos
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Cell Physiol 213:286-300. 2007
    Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types...
  6. ncbi Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy
    Sheng Xian Yuan
    Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
    Hepatology 56:2231-41. 2012
    ..Additionally, in 65 HCC samples, MVIH expression was inversely correlated with the serum level of PGK1 and positively correlated with the microvessel density...
  7. ncbi Liver regeneration: from myth to mechanism
    Rebecca Taub
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19004, USA
    Nat Rev Mol Cell Biol 5:836-47. 2004
    ..So what is known about this process at present and which questions remain?..
  8. pmc Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma
    R Tung-Ping Poon
    Centre of Liver Diseases, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Surg 232:10-24. 2000
    ..To evaluate the current knowledge on the risk factors for recurrence, efficacy of adjuvant therapy in preventing recurrence, and the optimal management of recurrence after resection of hepatocellular carcinoma (HCC)...
  9. pmc Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases
    Eddie K Abdalla
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg 239:818-25; discussion 825-7. 2004
    ..To examine recurrence and survival rates for patients treated with hepatic resection only, radiofrequency ablation (RFA) plus resection or RFA only for colorectal liver metastases...
  10. pmc Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas
    George K Michalopoulos
    University of Pittsburgh, Department of Pathology, School of Medicine, S 410 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Pathol 176:2-13. 2010
    Liver regeneration after partial hepatectomy is one of the most studied models of cell, organ, and tissue regeneration...
  11. ncbi World review of laparoscopic liver resection-2,804 patients
    Kevin Tri Nguyen
    Department of Surgery, UPMC Liver Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Ann Surg 250:831-41. 2009
    ..To provide a review of the world literature on laparoscopic liver resection...
  12. pmc Epidemiology and management of liver metastases from colorectal cancer
    Sylvain Manfredi
    Registre Bourguignon des Cancers Digestifs, Faculte de Medecine, Dijon Cedex, France
    Ann Surg 244:254-9. 2006
    ..The aim of this population-based study was to report on the incidence, treatment, and prognosis of synchronous and metachronous liver metastases...
  13. ncbi Current strategy for staging and treatment: the BCLC update and future prospects
    Alejandro Forner
    Barcelona Clinic Liver Cancer BCLC Group, Liver Unit, ICMDM, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Semin Liver Dis 30:61-74. 2010
    ..Finally, patients at end-stage should merely receive palliative care...
  14. pmc A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma
    Min shan Chen
    Department of Hepatobiliary Surgery, Cancer Centre of Sun Yat sen University, Guangzhou, China
    Ann Surg 243:321-8. 2006
    ..To compare the results of percutaneous local ablative therapy (PLAT) with surgical resection in the treatment of solitary and small hepatocellular carcinoma (HCC)...
  15. pmc Liver resection for hepatocellular carcinoma on cirrhosis: univariate and multivariate analysis of risk factors for intrahepatic recurrence
    Giorgio Ercolani
    Department of Surgery and Transplantation, Surgical Unit, S Orsola Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Ann Surg 237:536-43. 2003
    ..To evaluate prognostic factors that could affect disease-free survival and recurrence after liver resection for hepatocellular carcinoma (HCC) on cirrhosis...
  16. ncbi Continuous improvement of survival outcomes of resection of hepatocellular carcinoma: a 20-year experience
    Sheung Tat Fan
    State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong
    Ann Surg 253:745-58. 2011
    ..To investigate the trend of the posthepatectomy survival outcomes of hepatocellular carcinoma (HCC) patients by analysis of a prospective cohort of 1198 patients over a 20-year period...
  17. pmc Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival
    Rene Adam
    Centre Hépato Biliaire and Inserm E0354 Cancer Chronotherapeutics, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris Université Paris, Sud Villejuif, France
    Ann Surg 240:644-57; discussion 657-8. 2004
    ....
  18. ncbi Postoperative interferon alpha treatment postponed recurrence and improved overall survival in patients after curative resection of HBV-related hepatocellular carcinoma: a randomized clinical trial
    Hui Chuan Sun
    Liver Cancer Institute and Zhong Shan Hospital, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, People s Republic of China
    J Cancer Res Clin Oncol 132:458-65. 2006
    ..This study evaluated the effect of postoperative interferon alpha (IFN alpha) treatment on recurrence and survival in patients with hepatitis B virus (HBV)-related HCC...
  19. ncbi Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial
    Gunnar Folprecht
    University Hospital Carl Gustav Carus, Medical Department I University Cancer Center, Dresden, Germany
    Lancet Oncol 11:38-47. 2010
    ..Neoadjuvant chemotherapy for unresectable colorectal liver metastases can downsize tumours for curative resection. We assessed the effectiveness of cetuximab combined with chemotherapy in this setting...
  20. ncbi Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy
    Hiroshi Imamura
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 38:200-7. 2003
    ..We conducted a retrospective cohort study to investigate factors to early and late phase recurrence of hepatocellular carcinoma (HCC)...
  21. ncbi Effect of hepatocyte growth factor on progression of liver metastasis in colorectal cancer
    Shinji Osada
    Surgical Oncology, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Hepatogastroenterology 57:76-80. 2010
    ..To evaluate therapeutic approaches, the biological responses associated with hepatectomy were studied with a focus on hepatocyte growth factor (HGF).
  22. ncbi miRNA regulation of liver growth after 50% partial hepatectomy and small size grafts in rats
    Xiaoli Chen
    Department of Internal Medicine, Transplant Research Program, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Transplantation 91:293-9. 2011
    ..The aim of this study is to identify critical miRNA species that modulate the growth of small grafts and the remaining livers after partial hepatectomy (PH).
  23. ncbi Robotic hepatobiliary and pancreatic surgery: a cohort study
    Oliver C Y Chan
    Department of Surgery, Pamela Youde Nethersole Eastern Hospital, 3, Lok Man Road, Hong Kong SAR, China
    J Hepatobiliary Pancreat Sci 18:471-80. 2011
    ..This article aims to evaluate the efficacy and outcomes of robotic HBP surgery in a single surgical center...
  24. pmc Trends in long-term survival following liver resection for hepatic colorectal metastases
    Michael A Choti
    Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ann Surg 235:759-66. 2002
    ..To examine trends in outcomes of patients undergoing resection at a single tertiary care referral center over a 16-year period...
  25. ncbi Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients
    Myrddin Rees
    Department of Hepatobiliary Surgery, North Hampshire Hospital, Aldermaston Road, Basingstoke, Hampshire, United Kingdom
    Ann Surg 247:125-35. 2008
    ..To identify risk factors associated with cancer-specific survival and develop a predictive model for patients undergoing primary hepatic resection for metastatic colorectal cancer...
  26. ncbi Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
    Wendong Huang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 312:233-6. 2006
    ..FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth...
  27. ncbi The international position on laparoscopic liver surgery: The Louisville Statement, 2008
    Joseph F Buell
    Department of Surgery, Director of Transplantation, Jewish Hospital Transplant Center, 200 Abraham Flexner Way, Louisville, KY 40202, USA
    Ann Surg 250:825-30. 2009
    ..To summarize the current world position on laparoscopic liver surgery...
  28. ncbi Improving resectability of hepatic colorectal metastases: expert consensus statement
    Eddie K Abdalla
    The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Ann Surg Oncol 13:1271-80. 2006
  29. ncbi Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer
    L Rubbia-Brandt
    Division of Clinical Pathology, University Hospital, Geneva, Switzerland
    Ann Oncol 15:460-6. 2004
    ..The objective of this study was to assess the effects of preoperative systemic chemotherapy on the morphology of non-tumoral liver...
  30. pmc Laparoscopic liver resections: a feasibility study in 30 patients
    D Cherqui
    Departments of General and Digestive Surgery and Anesthesiology, H opital Henri Mondor Université Paris XII, Creteil, France
    Ann Surg 232:753-62. 2000
    ..To assess the feasibility and safety of laparoscopic liver resections...
  31. ncbi Resection of hepatocellular carcinoma with tumor thrombus in the major vasculature. A European case-control series
    Y Patrice Le Treut
    Department of Surgery and Liver Transplantation, Hopital de la Conception, 147 Boulevard Baille, 13385 Marseille Cedex 5, France
    J Gastrointest Surg 10:855-62. 2006
    ..Surgical technique was comparable in the VT and control group with regard to extent of hepatectomy, procedure duration, and transfusion requirements. Early postoperative outcome was also comparable...
  32. ncbi Prognostic significance of a combination of pre- and post-treatment tumor markers for hepatocellular carcinoma curatively treated with hepatectomy
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    J Hepatol 57:1251-7. 2012
    ..We investigated the prognostic value of a combination of these tumor markers for HCC, measured before and after treatment, on survival and recurrence in patients treated with hepatectomy.
  33. ncbi Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis
    Yohei Mano
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg 258:301-5. 2013
    To clarify the prognostic value of the preoperative blood neutrophil-to-lymphocyte ratio (NLR) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC).
  34. ncbi A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
    Claudia Mitchell
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Nat Protoc 3:1167-70. 2008
    ..of hepatocyte proliferation is directly proportional to the amount of resected liver tissue, and 2/3 partial hepatectomy (2/3 PH) leads to highly synchronized hepatocyte cell-cycle entry and progression...
  35. ncbi Hepatocellular carcinoma: current management and perspectives for the future
    Nuh N Rahbari
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
    Ann Surg 253:453-69. 2011
    ..To review the literature on current management of hepatocellular carcinoma (HCC)...
  36. pmc Endothelial nitric oxide synthase is a key mediator of hepatocyte proliferation in response to partial hepatectomy in mice
    Yu Mei
    Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine, and Texas Children s Liver Center, Houston, TX 77030, USA
    Hepatology 54:1777-89. 2011
    ..as one of the key humoral factors important for the initiation of liver regeneration in response to partial hepatectomy. Liver regeneration in response to partial hepatectomy is dependent on the efficiency of growth factor-mediated ..
  37. ncbi MicroRNA profiling in murine liver after partial hepatectomy
    Ioannis Chaveles
    Surgical Department, Medical School, University of Patras, 26504 Patras, Greece
    Int J Mol Med 29:747-55. 2012
    ..Multiple molecular and biochemical processes initiated after partial hepatectomy, lead to proliferation of all cells within the liver...
  38. ncbi Outcomes of hepatic resection for huge hepatocellular carcinoma (≥ 10 cm in diameter)
    Yo ichi Yamashita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Surg Oncol 104:292-8. 2011
    ..The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC) ≥ 10 cm...
  39. ncbi Liver resection for colorectal metastases
    Y Fong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 15:938-46. 1997
    ..The current study was performed to determine if liver resection for colorectal metastases is safe and effective and to evaluate predictors of outcome...
  40. ncbi A prospective, randomized, controlled trial of preoperative transarterial chemoembolization for resectable large hepatocellular carcinoma
    Wei Ping Zhou
    The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
    Ann Surg 249:195-202. 2009
    ..To evaluate the effect of preoperative transarterial chemoembolization (TACE) for resectable large hepatocellular carcinoma (HCC)...
  41. ncbi Long-term results of hepatic resection for hepatocellular carcinoma originating from the noncirrhotic liver
    Che Hua Chang
    Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, and College of Medicine, National Yang Ming University, Taipei, Taiwan
    Arch Surg 139:320-5; discussion 326. 2004
    ..In patients with hepatocellular carcinoma who do not have cirrhosis, the clinicopathologic characteristics and long-term postresectional outcomes must be clarified and liver transplantation may also have a role in future treatment strategy...
  42. ncbi Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Radiology 247:260-6. 2008
    To retrospectively evaluate the long-term results of radiofrequency (RF) ablation combined with chemoembolization (combination therapy) as compared with hepatectomy for the treatment of early-stage hepatocellular carcinoma (HCC).
  43. pmc Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma
    Masami Minagawa
    Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Ann Surg 238:703-10. 2003
    ..The purpose of this study was to evaluate prognostic factors in patients with recurrence after curative resection of hepatocellular carcinoma (HCC) and to identify selection criteria for repeat resection...
  44. pmc Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
    Y Yamada
    Department of Pathology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 94:1441-6. 1997
    ..are involved in the initiation of liver growth, we studied the regeneration of the liver after partial hepatectomy (PH) in mice lacking type I tumor necrosis factor receptor (TNFR-I)...
  45. ncbi Laparoscopic vs open hepatic resection: a comparative study
    M Morino
    Second Department of General Surgery, University of Turin, C so A M Dogliotti 14, 10126 Turin, Italy
    Surg Endosc 17:1914-8. 2003
    ..Although the feasibility of minor laparoscopic liver resections (LLR) has been demonstrated, data comparing the open vs the laparoscopic approach to liver resection are lacking...
  46. ncbi Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy
    T Sakamoto
    Thomas E Starzl Transplantation Institute, Division of Transplantation, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 29:403-11. 1999
    Recently, it was shown that hepatocyte DNA synthesis after partial hepatectomy (PH) is impaired in interleukin-6-deficient (IL-6(-/-)) mice, which results in significantly delayed, but eventual, recovery of normal liver weight, compared ..
  47. ncbi Isolation of primary human hepatocytes after partial hepatectomy: criteria for identification of the most promising liver specimen
    Florian Wolfgang Rudolf Vondran
    Department of General, Visceral, and Transplantation Surgery, Charite Universitatsmedizin Berlin, Campus Virchow, Berlin, Germany
    Artif Organs 32:205-13. 2008
    ..The indication for surgery is a valuable basis for identifying the most yielding specimens. Hepatocytes from donors with high GGT levels appear to show reduced functional properties...
  48. ncbi Vascular control during hepatectomy: review of methods and results
    Vassilios Smyrniotis
    Second Department of Surgery, Athens University Medical School, Aretaieion Hospital, 76 Vassilisis Sofias Avenue, Athens 11528, Greece
    World J Surg 29:1384-96. 2005
    ..Newer perspectives on the field emerge from the introduction of ischemic preconditioning and laparoscopic hepatectomy. A literature review based on computer searches in Index Medicus and PubMed focuses mainly on prospective ..
  49. pmc Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma
    W R Jarnagin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg 234:507-17; discussion 517-9. 2001
    ..To analyze resectability and survival in patients with hilar cholangiocarcinoma according to a proposed preoperative staging scheme that fully integrates local, tumor-related factors...
  50. ncbi Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy
    Hiroshi Nakano
    Centre de Chirurgie Viscerale et de Transplantation, Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, Universite Louis Pasteur, Avenue Moliere, Strasbourg, France
    Ann Surg 247:118-24. 2008
    To investigate whether sinusoidal injury (SI) was associated with a worse outcome after hepatectomy in patients with colorectal liver metastases (CRLM).
  51. pmc Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years
    R T Poon
    Centre for the Study of Liver Disease, Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    Ann Surg 234:63-70. 2001
    ....
  52. ncbi Perioperative factors affecting long-term outcomes of 473 consecutive patients undergoing hepatectomy for hepatocellular carcinoma
    Chih Chi Wang
    Department of Surgery, Division of General Surgery, Liver Transplant Program, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Niao Sung, Kaohsiung, Taiwan
    Ann Surg Oncol 16:1832-42. 2009
    ..The aim of this study was to evaluate the long-term outcomes of liver resection for hepatocellular carcinoma (HCC)...
  53. ncbi Laparoscopic versus open liver resection of hepatic neoplasms: comparative analysis of short-term results
    B Topal
    Department of Abdominal Surgery, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Surg Endosc 22:2208-13. 2008
    ..Concerns have been raised regarding outcome after laparoscopic resection of hepatic neoplasms. This prospective study compared morbidity and adequacy of surgical margins in laparoscopic (LLR) versus open liver resection (OLR)...
  54. ncbi Laparoscopic liver resection
    E Vibert
    Department of Digestive Diseases, Montsouris Institute, University Paris V, 42 Boulevard Jourdan, 75014 Paris, France
    Br J Surg 93:67-72. 2006
    ..This paper describes a 10-year experience of laparoscopic liver surgery, including several major hepatectomies for malignant tumours...
  55. ncbi Meta-analysis: interferon improves outcomes following ablation or resection of hepatocellular carcinoma
    A K Singal
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, 77555 0764, USA
    Aliment Pharmacol Ther 32:851-8. 2010
    ..Surgical resection and tumour ablation are curative in patients who cannot be transplanted. With native liver having cirrhosis, HCC recurrence is a potential problem...
  56. ncbi Percutaneous radiofrequency ablation versus partial hepatectomy for multicentric small hepatocellular carcinomas: a nonrandomized comparative study
    Wei Xing Guo
    Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, No 225 Changhai Road, 200438, Shanghai, China
    World J Surg 34:2671-6. 2010
    ..of this study was to compare the results of percutaneous radiofrequency ablation (RFA) with those of partial hepatectomy (PH) in the treatment of multicentric small hepatocellular carcinomas (HCCs)...
  57. ncbi Role of squamous cell carcinoma antigen-1 on liver cells after partial hepatectomy in transgenic mice
    Gianmarco Villano
    Department of Clinical and Experimental Medicine, University of Padova, I 35123 Padova, Italy
    Int J Mol Med 25:137-43. 2010
    ..aim of this study was to evaluate the effect of SCCA1 on liver cells in a transgenic mouse model after partial hepatectomy. Twenty-one C57BL/6J mice (11 transgenic for human SCCA1, 10 wild-type) underwent partial hepatectomy and were ..
  58. ncbi Clinical significance of lymph node metastasis in patients undergoing partial hepatectomy for hepatocellular carcinoma
    Shen Xiaohong
    Medical College of Nankai University, Tianjin, 300071, China
    World J Surg 34:1028-33. 2010
    ..The purpose of the present study was to evaluate the incidence, site, and impact on survival of LN metastasis in patients with HCC amenable to curative liver resection and routine regional lymphadenectomy...
  59. ncbi Minimally invasive liver resection for metastatic colorectal cancer: a multi-institutional, international report of safety, feasibility, and early outcomes
    Kevin Tri Nguyen
    Department of Surgery, Division of Transplantation, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg 250:842-8. 2009
    ..To evaluate a multicenter, international series on minimally invasive liver resection for colorectal carcinoma (CRC) metastasis...
  60. ncbi A comparative study of antiviral therapy after resection of hepatocellular carcinoma in the immune-active phase of hepatitis B virus infection
    Nan Li
    Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
    Ann Surg Oncol 17:179-85. 2010
    The role of antiviral therapy for patients in the immune-active phase of hepatitis B virus (HBV) infection who underwent partial hepatectomy for hepatocellular carcinoma (HCC) is unknown.
  61. ncbi Neither multiple tumors nor portal hypertension are surgical contraindications for hepatocellular carcinoma
    Takeaki Ishizawa
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Gastroenterology 134:1908-16. 2008
    ..The surgical indications for multiple hepatocellular carcinomas (HCCs) and for HCC with portal hypertension (PHT) remain controversial...
  62. ncbi Significance of alpha-fetoprotein and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma undergoing hepatectomy
    Kentaroh Yamamoto
    Department of Surgery, Hepato Biliary Pancreatic Surgery Division, Artificial Organ and Transplantation Division, University of Tokyo, Tokyo, Japan
    Ann Surg Oncol 16:2795-804. 2009
    ..resections, determine the correlations between the marker levels and clinicopathological prognostic variables, and determine the correlations between the marker levels before hepatectomy and those at diagnosis of recurrence.
  63. ncbi Neoadjuvant chemotherapy followed by hepatectomy for primarily resectable colorectal cancer liver metastases
    Antonio Chiappa
    Department of General Surgery, European Institute of Oncology, Milano, Italy
    Hepatogastroenterology 56:829-34. 2009
    ....
  64. ncbi Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice
    Yohji A Minamishima
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Fukuoka 812 8582, Japan
    Cancer Res 62:995-9. 2002
    ..The role of Skp2 in cell growth and proliferation was investigated in Skp2-deficient mice subjected to partial hepatectomy. Skp2(-/-) mice exhibited restoration of liver mass without cell proliferation; rather, hepatocytes increased ..
  65. pmc Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury
    J I Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 21:414-24. 2001
    ..growth factor binding protein 1 (IGFBP-1) gene is dramatically altered by changes in the metabolic state and hepatectomy, and thus it provided an appropriate reporter to assess the transcriptional milieu in the liver during repair ..
  66. ncbi Intrahepatic Glissonian approach for laparoscopic right segmental liver resections
    Marcel Autran C Machado
    Department of Gastroenterology, University of Sao Paulo, Rua Evangelista Rodrigues 407, 05463 000 São Paulo, Brazil
    Am J Surg 196:e38-42. 2008
    ..However, laparoscopic liver resection has not been widely developed and anatomical segmental liver resection is not currently performed due to difficulty to control segmental Glissonean pedicles laparoscopically...
  67. ncbi Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases
    Lorenzo Capussotti
    Divisione Chirurgia Oncologica, Istituto per la Ricerca e la Cura del Cancro, Strada Provinciale 142 km 3, 95, 10060 Candiolo, Italy
    Arch Surg 143:978-82; discussion 982. 2008
    ..Portal vein ligation has been suggested to be less effective than embolization in inducing hypertrophy of the remnant liver...
  68. ncbi Surgical resection of pulmonary metastases from colorectal cancer: a systematic review of published series
    Joachim Pfannschmidt
    Department of Thoracic Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Thorac Surg 84:324-38. 2007
    ....
  69. pmc Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats
    Lin Wang
    Division of Gastrointestinal and Liver Disease and University of Southern California Research Center for Liver Disease, Los Angeles, California 90033, USA
    J Clin Invest 122:1567-73. 2012
    ..BM LSEC progenitors did not contribute to normal LSEC turnover in the liver. However, after partial hepatectomy, BM LSEC progenitor proliferation and mobilization to the circulation doubled...
  70. ncbi Laparoscopic versus open resection of hepatic colorectal metastases
    Robert M Cannon
    University of Louisville, Department of Surgery, Division of Surgical Oncology, Louisville, KY 40202, USA
    Surgery 152:567-73; discussion 573-4. 2012
    ..This study was undertaken to assess the safety and efficacy of laparoscopic versus open resection of hepatic colorectal metastases (CRM)...
  71. ncbi Timing of hepatectomy in resectable synchronous colorectal liver metastases (SCRLM): Simultaneous or delayed?
    Zi Yin
    General Surgery Department of Sun Yat sen Memorial Hospital, Sun Yat Sen University, Guangzhou, China
    Hepatology 57:2346-57. 2013
    ..12; 95% CI: 0.61-2.08; P = 0.71; I(2) = 32%). Finally, selection criteria were recommended for SCRLM patients suitable for a simultaneous resection...
  72. ncbi Recurrence after liver resection for hepatocellular carcinoma: risk factors, treatment, and outcomes
    Shimul A Shah
    Department of Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Surgery 141:330-9. 2007
    ..The purpose of this study was to identify risk factors for the recurrence of HCC and to examine long-term outcomes after resection...
  73. pmc Comparative evaluation of laparoscopic liver resection for posterosuperior and anterolateral segments
    Airazat M Kazaryan
    Interventional Centre, Rikshospitalet, Oslo University Hospital Health Trust, 0027 Oslo, Norway
    Surg Endosc 25:3881-9. 2011
    ..Totally laparoscopic liver resection of lesions located in the posterosuperior segments is reported to be technically challenging. This study aimed to define whether these technical difficulties affect the surgical outcome...
  74. ncbi Secreted factors of human liver-derived mesenchymal stem cells promote liver regeneration early after partial hepatectomy
    Suomi M G Fouraschen
    Laboratory of Experimental Transplantation and Intestinal Surgery, Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stem Cells Dev 21:2410-9. 2012
    ..C57BL/6 mice were subjected to a 70% partial hepatectomy and treated with either concentrated MSC-conditioned culture medium (MSC-CM) or vehicle control...
  75. ncbi Outcome of laparoscopic major liver resection for colorectal metastases
    Halit Topal
    Department of Abdominal Surgery, University Hospitals Leuven KUL, Herestraat 49, 3000 Leuven, Belgium
    Surg Endosc 26:2451-5. 2012
    ..However, data are still lacking on the feasibility, long- and short-term outcomes of laparoscopic major hepatectomy (i.e., three or more liver segments).
  76. ncbi A snapshot of the effective indications and results of surgery for hepatocellular carcinoma in tertiary referral centers: is it adherent to the EASL/AASLD recommendations?: an observational study of the HCC East-West study group
    Guido Torzilli
    Liver Surgery Unit, Department of Surgery, University of Milan School of Medicine, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Ann Surg 257:929-37. 2013
    ..The aim of this study was to investigate in a retrospective setting the patients' profile and results of those undergoing surgery for hepatocellular carcinoma (HCC) in high-volume surgical centers throughout the world...
  77. ncbi recurrence following hepatectomy for metastatic colorectal cancer: development of a model that predicts patterns of recurrence and survival
    Charles R St Hill
    Department of Surgery, Division of Surgical Oncology, University of Louisville, Louisville, KY, USA
    Ann Surg Oncol 19:139-44. 2012
    While several prognostic models have been developed to predict survival of patients who undergo hepatectomy for metastatic colorectal cancer (mCRC), few data exist to predict survival after recurrence...
  78. ncbi Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria
    Kheng Choon Lim
    Centre for Quantitative Medicine, Duke NUS Graduate Medical School, Singapore
    Ann Surg 254:108-13. 2011
    ..To compare microvascular invasion (McVI) with parameters defined by the Milan criteria in predicting tumor recurrence and overall survival (OS) in patients with surgical resection (SR) for hepatocellular carcinoma (HCC)...
  79. ncbi Outcome of partial hepatectomy for large (> 10 cm) hepatocellular carcinoma
    Kui Hin Liau
    Hepatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 104:1948-55. 2005
    Surgical resection for large (> 10 cm) hepatocellular carcinoma (HCC) is believed by many to be ineffective. The objective of the current study was to review the outcome of partial hepatectomy in patients with large HCC.
  80. ncbi Serum and tissue vascular endothelial growth factor predicts prognosis in hepatocellular carcinoma patients after partial liver resection
    Chong Zhong
    Department of Hepatobiliary Surgery, Guangzhou University of Chinese Medicine, Guanghou, China
    Hepatogastroenterology 59:93-7. 2012
    ..To explore the effect of vascular endothelial growth factor (VEGF) expression on prognosis of hepatocellular carcinoma (HCC) after partial liver resection...
  81. ncbi Predicting high grade lesions of sinusoidal obstruction syndrome related to oxaliplatin-based chemotherapy for colorectal liver metastases: correlation with post-hepatectomy outcome
    Olivier Soubrane
    Department of Hepatobiliary Surgery, Hopital Saint Antoine, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Ann Surg 251:454-60. 2010
    ....
  82. ncbi Propranolol impairs liver regeneration after partial hepatectomy in C57Bl/6-mice by transient attenuation of hepatic lipid accumulation and increased apoptosis
    Jens Walldorf
    First Department of Medicine, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
    Scand J Gastroenterol 45:468-76. 2010
    Acute hepatic fat accumulation appears to be crucial for liver regeneration after partial hepatectomy. Since fatty acids in the liver are provided by catecholamine-induced lipolysis in the adipose tissue, we investigated whether beta-..
  83. pmc Prognostic impact of anatomic resection for hepatocellular carcinoma
    Kiyoshi Hasegawa
    Division of Hepato Biliary Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Ann Surg 242:252-9. 2005
    ..To evaluate the prognostic impact of anatomic versus nonanatomic resection on the patients' survival after resection of a single hepatocellular carcinoma (HCC)...
  84. ncbi Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009
    Donald Poon
    National Cancer Centre, Singapore Duke NUS Graduate Medical School, Singapore
    Lancet Oncol 10:1111-8. 2009
    ....
  85. ncbi Laparoscopic liver resection of benign liver tumors
    B Descottes
    Hopital Universitaire Dupuyten, Limoges, France
    Surg Endosc 17:23-30. 2003
    ..The objective of this study was to assess the feasibility, safety, and outcome of laparoscopic liver resection for benign liver tumors in a multicenter setting...
  86. ncbi Trends in perioperative outcome after hepatic resection: analysis of 1500 consecutive unselected cases over 20 years
    Matteo Cescon
    Liver and Multiorgan Transplant Unit, Sant Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Ann Surg 249:995-1002. 2009
    ..To estimate risk factors affecting the early outcome after hepatic resection in a high volume center specialized in hepatobiliary surgery and to analyze the changing of results during 3 different periods of treatment...
  87. ncbi Safety of hepatic resection in metastatic disease to the liver after yttrium-90 therapy
    Ryan Whitney
    Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    J Surg Res 166:236-40. 2011
    ..The goal of this review was to evaluate the use of yttrium-90 hepatic arterial therapy in the management of hepatic metastases and surgical downstaging...
  88. pmc Laparoscopic liver resection for malignant liver tumors: preliminary results of a multicenter European study
    Jean Francois Gigot
    Saint Luc University Hospital, Brussels, Belgium
    Ann Surg 236:90-7. 2002
    ..To assess the feasibility, safety, and outcome of laparoscopic liver resection for malignant liver tumors...
  89. ncbi One thousand fifty-six hepatectomies without mortality in 8 years
    Hiroshi Imamura
    Division of Hepato Biliary Pancreatic Surgery and Artificial Organ and Transplantation, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arch Surg 138:1198-206; discussion 1206. 2003
    ..Despite improvements in diagnostic and surgical techniques, operative mortality associated with liver resection is still greater than 2% in most of the recent studies...
  90. ncbi Laparoscopic vs open hepatic resection for benign and malignant tumors: An updated meta-analysis
    Kris P Croome
    Harvard School of Public Health, Boston, Massachusetts, USA
    Arch Surg 145:1109-18. 2010
    ..To compare laparoscopic hepatic resection (LHR) with open hepatic resection (OHR) for benign and malignant tumors...
  91. ncbi A long-term follow-up and management study of hepatocellular carcinoma patients surviving for 10 years or longer after curative hepatectomy
    Kazuaki Shimada
    Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer 104:1939-47. 2005
    ..of the current study were to elucidate the clinicopathologic characteristics and disease recurrence patterns of patients with hepatocellular carcinoma (HCC) who survived for 10 years or longer after undergoing an initial hepatectomy.
  92. ncbi Vitamin D3 up-regulated protein 1 deficiency accelerates liver regeneration after partial hepatectomy in mice
    Hyo Jung Kwon
    Biomedical Mouse Resource Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea
    J Hepatol 54:1168-76. 2011
    ..Here, we investigated the function of VDUP1 in liver regeneration following hepatectomy in mice.
  93. ncbi Laparoscopic liver resection
    Srinevas K Reddy
    Department of Surgery, UPMC Liver Cancer Center, Starzl Transplant Institute, University of Pittsburgh, 3459 Fifth Avenue, UPMC Montefiore 7 South, Pittsburgh, PA 15213, USA
    World J Surg 35:1478-86. 2011
    ..laparoscopic liver resections (LLR) are performed worldwide for benign disease, malignancy, and living donor hepatectomy. Minimally invasive hepatic resection approaches include pure laparoscopic, hand-assisted laparoscopic, and a ..
  94. pmc Robotic liver resection as a bridge to liver transplantation
    Fabrizio Panaro
    Centre de Chirurgie Viscerale et de Transplantation, Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    JSLS 15:86-9. 2011
    ..Robotic surgery for hepatic resection has not yet been extensively reported. The aim of this article is to report the first known case of liver resection with the use of a robot in France...
  95. ncbi Is perioperative chemotherapy useful for solitary, metachronous, colorectal liver metastases?
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, Univ Paris Sud, UMR S 776, Villejuif, France
    Ann Surg 252:774-87. 2010
    ..The aim of our study was to address the still pending question of whether perioperative chemotherapy is really beneficial in patients developing solitary metastases at a distance from surgery of the primary...
  96. ncbi Effect on outcome of recurrence patterns after hepatectomy for colorectal metastases
    Michael D'Angelica
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 18:1096-103. 2011
    Despite improvements in surgery and chemotherapy, most patients develop recurrence after hepatectomy for metastatic colorectal cancer. Data are lacking on the effect of these patterns on outcome.
  97. ncbi Bile leak test by indocyanine green fluorescence images after hepatectomy
    Takanori Sakaguchi
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Surg 200:e19-23. 2010
    Bile leak remains a serious complication after hepatectomy. The conventional leak test by intrabiliary injection of normal saline solution is not sensitive...
  98. ncbi Impact of antiviral therapy on the survival of patients after major hepatectomy for hepatitis B virus-related hepatocellular carcinoma
    Albert C Y Chan
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region
    Arch Surg 146:675-81. 2011
    To assess whether commencement of antiviral therapy after hepatectomy improves the prognosis of hepatocellular carcinoma (HCC) in preoperatively antiviral-naive patients with chronic hepatitis B virus (HBV) infection.
  99. ncbi Histological liver injury and surgical outcome after FOLFOX followed by a hepatectomy for colorectal liver metastases in Japanese patients
    Hiroyuki Komori
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjyo, Kumamoto, 860 8556, Japan
    Int J Clin Oncol 15:263-70. 2010
    ....
  100. ncbi Combined portal vein embolization and neoadjuvant chemotherapy as a treatment strategy for resectable hepatic colorectal metastases
    Anne M Covey
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 247:451-5. 2008
    ..to determine whether the future liver remnant will grow after portal vein embolization (PVE) in patients with colon cancer on concurrent chemotherapy and 2) to determine whether recovery after extended hepatectomy is improved after PVE.
  101. ncbi Robot-assisted right lobe donor hepatectomy
    Pier Cristoforo Giulianotti
    Division of Minimally Invasive, General Surgery and Robotic Surgery, University of Illinois at Chicago, Chicago, IL, USA
    Transpl Int 25:e5-9. 2012
    ..major robotic liver resections, we determined that it was safe to apply this technology to right lobe donor hepatectomy (RLDH)...

Research Grants65

  1. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..Normal controls will include 10 subjects providing tissue by partial hepatectomy for benign conditions...
  2. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..a dramatic increase in PDGFR[unreadable] temporally during liver regeneration after two-third or partial hepatectomy (PH) in mice...
  3. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..Using a mouse model system of liver regeneration induced by 70% partial hepatectomy, we recently made the novel discovery that liver regeneration is impaired in the absence of MCP-1...
  4. IKKbeta:Bi-Functional Regulator of Hepatocyte Proliferation
    Hyam L Leffert; Fiscal Year: 2010
    ..New investigations have revealed that following 70% partial hepatectomy, mouse liver regeneration starts faster and the diethylnitrosamine- induced incidence of hepatocellular ..
  5. Molecular mechanisms of C/EBP alpha mediated growth arrest
    Nikolai A Timchenko; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Liver is a unique tissue which is able to regenerate in response to partial hepatectomy (PH) and after injury...
  6. Mechanisms of oval cell activation and differentiation
    Bryon E Petersen; Fiscal Year: 2013
    ..provided by applicant): The liver has an enormous capacity to regenerate, as demonstrated by the 2/3 partial hepatectomy model in rodents...
  7. Investigation of the liver progenitor cell niche using CK19 lineage tracing
    EUGENE SCOTT SWENSON; Fiscal Year: 2011
    ..the role of intrahepatic CK19+ hepatic progenitor cells during liver regeneration after injury by 1) partial hepatectomy and 2) acute acetaminophen injury...
  8. Regulation of Cell Growth by RNA Binding Proteins
    Nikolai A Timchenko; Fiscal Year: 2012
    ..In tumor livers and in livers proliferating after partial hepatectomy (PH), CUGBP1 is hyper-phosphorylated and this phosphorylation increases translational activities of CUGBP1...
  9. ENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESIS
    NICHOLAS DAVIDSON; Fiscal Year: 2013
    ..of Acf is embryonic lethal and heterozygous Acf mice demonstrate delayed liver regeneration following partial hepatectomy (PH)...
  10. Innate immune suppression following experimental injury
    KRISTIN C GREATHOUSE; Fiscal Year: 2012
    ..functions of phagocytosis and killing in a mouse model of injury-induced immune suppression (partial hepatectomy), and hypothesize that phagocyte function is also suppressed following injury...
  11. Complement and cytokine network in liver regeneration
    John D Lambris; Fiscal Year: 2011
    ..The regenerative response is impaired after partial hepatectomy (PHx) and carbon tetrachloride (CCI4) injury in several mouse strains deficient in complement components...
  12. microRNA Uncoupling of Protein and Transcript Expression in Liver Regeneration
    CLIFFORD JOHN STEER; Fiscal Year: 2010
    ..define the role of microRNAs in the regulation of gene expression in regenerating rat liver after 70% partial hepatectomy (PH)...
  13. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2013
    ..of A20 translate into a dramatic regenerative advantage with greatly improved survival following radical lethal hepatectomy or prolonged liver ischemia in mice...
  14. A20 Gene Polymorphisms in LDLT
    Christiane Ferran; Fiscal Year: 2012
    ..animal models, we have shown that overexpression of A20 in the liver is protective following radical lethal hepatectomy and severe liver ischemia reperfusion injury, and allows for successful engraftment of marginal liver ..
  15. LDLT: Diagnostic Markers of Liver Regeneration to Predict Outcomes
    Elizabeth A Pomfret; Fiscal Year: 2013
    ..the in-depth examination of factors that affect the ability of liver tissue to regenerate after live donor hepatectomy or receipt of a partial liver allograft in a living donor liver transplant (LDLT)...
  16. The transcriptional basis of tumor promotion
    Joseph D Locker; Fiscal Year: 2013
    ..TCPOBOP;(2) antipromotional hyperplasia induced by thyroid hormone;(3) rapid liver regeneration after partial hepatectomy (PH) in the rat; and (4) more protracted regeneration after PH in the mouse...
  17. Role of Bile Acids in the Initiation of Liver Regeneration
    Willscott E Naugler; Fiscal Year: 2013
    ..Aim 1 will determine the role of bile acids in the initiation of liver regeneration using a model of partial hepatectomy. In Aim 2 a model of bile acid administration through the portal vein will allow the focused study of the ..
  18. The Cell-autonomous Contributions of UHRF1 to Liver Development and Regeneration
    Vinitha Jacob; Fiscal Year: 2013
    ..In addition, adult uhrf1 heterozygotes fail to regenerate their livers after partial hepatectomy, a defect found to be specific to the liver [5]...
  19. Histone methyltransferase EZH2 in liver pathophysiology and carcinogenesis
    Hong Lu; Fiscal Year: 2012
    ..Aim 1 will determine the importance of EZH2 in liver regeneration using models of 2/3 partial hepatectomy in EZH2-LKO mice...
  20. Stem cells in liver regeneration: fusion or plasticity
    Bryon E Petersen; Fiscal Year: 2013
    ..provided by applicant): The liver has an enormous capacity to regenerate, as demonstrated by the 2/3 partial hepatectomy model in rodents. In addition, the liver has a stem cell compartment acting as a backup regenerative system...
  21. Liver Dendritic Cells in Tolerance and Immunity
    Ronald P Dematteo; Fiscal Year: 2013
    ..applicant): Liver ischemia reperfusion (I/R) induces an untoward hyperinflammatory response following partial hepatectomy, liver transplantation, and hypovolemic shock. Currently, there are no effective therapies...
  22. p53-Regulation in Liver Regeneration
    MICHELLE ANN BARTON; Fiscal Year: 2012
    Renewed organogenesis of the fully differentiated liver is stimulated in response to surgical removal (partial hepatectomy, PHx) or destruction of liver tissue by chemicals or disease...
  23. Role of FGF10 in liver organogenesis and alcohol-impaired regeneration
    KASPER SAONUN WANG; Fiscal Year: 2010
    ..during liver regeneration, we have evidence that Fgf 10 expression, which is upregulated after partial hepatectomy, is reduced in the setting of ethanol-induced impaired liver regeneration...
  24. Dual role of complement in post-ischemic inflammation and recovery
    Stephen Tomlinson; Fiscal Year: 2012
    ..changes (neoepitope exposure) and the complement activation event that occurs after either IR or partial hepatectomy. We will also utilize complement inhibitors that function at different points in the cascade to investigate ..
  25. Role of Wnt/Beta-Catenin Signaling in Liver Development
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..liver regeneration &showed activation of the Wnt/[unreadable]-catenin signaling immediately after partial-hepatectomy (PHx)...
  26. Chemokine regulation of liver injury and recovery
    Alex B Lentsch; Fiscal Year: 2013
    ..Much of our current knowledge regarding liver regeneration has been obtained using animal models of hepatectomy. While the information gained from these models has been invaluable, this model is not clinically relevant to ..
  27. Adult to Adult Living Donor Liver Transplantation Cohort Study (A2ALL)
    James Burton; Fiscal Year: 2013
    ..long-term assessment of donors and donor controls - for the purpose of assessing the impact of donor hepatectomy and living donation on subsequent health, quality of life, and psycho-social function of donors...
  28. HGF and Signaling Pathways in Hepatic Tissue Assembly
    George K Michalopoulos; Fiscal Year: 2013
    ..We further extend these studies in rats and performed a double KD of both HGF/Met and EGFR followed by partial hepatectomy (PHx)...
  29. The Role of Complement in Hepatic Ischemia Reperfusion Injury and Regeneration
    KEELY MORRIS; Fiscal Year: 2013
    ..goals of this project are to understand the proximal events involved in complement activation following IR or hepatectomy, and to characterize differences in complement effector mechanisms involved in IRI and regeneration...
  30. Identification of vascular inductive signals in liver regeneration
    Shahin Rafii; Fiscal Year: 2013
    ..We have found that after 70% partial hepatectomy (PH), activation of liver sinusoidal endothelial cells (LSECs) by production of paracrine factors, defined as ..
  31. Laser Device Development and Qualification to Enable Laser Tissue Welding
    CRAIG LENNON; Fiscal Year: 2010
    ..biomaterials, will provide quick and accurate hemostasis and biliary sealing after liver resection surgery or hepatectomy for benign/primary/secondary liver neoplasms...
  32. Nrf2, Hepatocyte Proliferation, and Liver Regeneration
    Guoli Dai; Fiscal Year: 2013
    ..Furthermore, our preliminary studies demonstrated that Nrf2 is highly activated during partial hepatectomy (PH)-induced liver regeneration and lack of Nrf2 leads to severely suppressed liver growth after PH...
  33. Role of Age in Liver Cancer
    Nikolai A Timchenko; Fiscal Year: 2013
    ..which mimic the age-associated ph-S193 isoform of C/EBPa and found that liver proliferation after partial hepatectomy is completely inhibited in S193D mice...
  34. The MicroRNA Network and the Deregulation of Liver Regeneration by Ethanol
    Rajanikanth Vadigepalli; Fiscal Year: 2013
    ..chronic ethanol feeding alters the pattern of microRNA changes occurring in the remnant liver after partial hepatectomy (PHx) in the rat...
  35. Adult to Adult Living Donor Liver Transplantation Cohort Study
    Jean C Emond; Fiscal Year: 2013
    ..determining using a control population of concurrently enrolled laparoscopic renal donors whether more limited hepatectomy will improve psychological health of donors...
  36. EGFR therapies for fatty liver surgery
    Leonidas G Koniaris; Fiscal Year: 2013
    ..is that reduced hepatocyte EGFR signaling leads directly to reduced survival and impaired recovery after hepatectomy. Rescue of survival after fatty liver surgery by resveratrol is mediated at least partly by EGFR up-regulation, ..
  37. Ethanol Effects on the Transcriptional Regulatory Network in Liver Regeneration
    Rajanikanth Vadigepalli; Fiscal Year: 2013
    ..Our proposed studies will examine how the transcriptional regulatory network response after partial hepatectomy in the rat is affected by chronic alcohol intake...
  38. MOLECULAR CONTROL OF LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    DESCRIPTION: Liver regeneration following partial hepatectomy provides one of the few examples of a physiologic growth response occurring in the intact animal...
  39. METABOLIC HOMEOSTASIS IN LIVER REGENERATION
    LINDA GREENBAUM; Fiscal Year: 1999
    Liver regeneration following partial hepatectomy is one of the few models in which it is possible to study cellular proliferation in the intact animal...
  40. MOLECULAR REGULATION OF LIVER REGENERATION
    Clifford Steer; Fiscal Year: 1999
    ..in the expression of cell cycle- and growth-dependent genes in the regenerating rat liver after partial hepatectomy. The hypothesis is that this posttranscriptional mechanism is primarily responsible for the regulation of mRNA ..
  41. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..protection and regeneration during acetaminophen-induced liver toxicity, as well as following 70 percent hepatectomy. SCF is well-known as an important leukocyte hematopoietic factor, involved in the proliferation and maturation ..
  42. GENE EXPRESSION IN REGENERATING AND NEOPLASTIC LIVERS
    Nelson Fausto; Fiscal Year: 2000
    During liver regeneration after partial hepatectomy (PH), normally quiescent hepatocytes enter the cell cycle and replicate...
  43. The Role of Complement in Liver Regeneration
    John Lambris; Fiscal Year: 2005
    ..The liver has the capacity to regulate its size and growth and to regenerate after partial hepatectomy or toxic injury...
  44. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
    ..A failure to diminish this complex after partial hepatectomy seems to be a major cause for the reduced proliferative response in old livers...
  45. Hepatic engraftment of marrow cells in mice and humans
    Neil Theise; Fiscal Year: 2004
    ..perivenular and periportal hepatocytes, biliary epithelium); and pan-organ hypertrophy after partial hepatectomy. The long term aim is to determine if this hepatic engraftment is functional...
  46. PROGRESSION OF HEPATIC NEOPLASIA BY PCB/ARSENIC MIXTURES
    JON PAINTER; Fiscal Year: 2004
    ..initiation/promotion/progression (IPP) assay in the rat using dimethylnitrosamine (DEN) initiation, partial hepatectomy, and subchronic PCB mixture treatment...
  47. Cell Volume Regulated Biology in the Liver
    Ravi Chari; Fiscal Year: 2005
    DESCRIPTION (adapted from the application) Immediately after partial hepatectomy (PH), hepatocytes exhibit alterations in membrane hyperpolarization, ion fluxes, and intracellular pH that induce cell volume changes...
  48. Glycosylation Mutants of Mice and Animal Cells
    PAMELA M STANLEY; Fiscal Year: 2010
    ..W-glycans of non-hepatocyte glycoprotein(s) promotes hepatocarcinogenesis and liver regeneration after partial hepatectomy;and 3) deletion of mouse protein O-fucosyltransferase 1 generates a canonical Notch signaling phenotype ..
  49. Preparative irradiation for hepatocyte transplantation
    Chandan Guha; Fiscal Year: 2009
    ..Our preliminary results demonstrate that preparative HIR and partial hepatectomy (PH), followed by HT results in the replacement of virtually all host hepatocytes by the transplanted non-..
  50. C/EBP ALPHA MEDIATED REGULATION OF P21/SDI-1
    Nikolai Timchenko; Fiscal Year: 2001
    ..it is likely that changes in the pattern regeneration will be detected in p21 knock-out liver following partial hepatectomy. We will use another genetic knockout model (for the C/EBPa gene) to investigate the developmental expression ..
  51. CYTOPLASMIC FACTORS IN CELLULAR GROWTH
    NANCY BUCHER; Fiscal Year: 1999
    ..activity in response to an excessive metabolic workload, imposed by the body, and set in motion by partial hepatectomy. The aim is to find molecular mechanisms through which this workload is translated into liver growth...
  52. MOLECULAR REGUL OF HUMAN COLON CANCER LIVER METASTASIS
    Robert Radinsky; Fiscal Year: 1999
    ..Highly metastatic HCC cells also respond to specific mitogenic signals produced by tissue undergoing repair (hepatectomy followed by liver regeneration) demonstrating that physiological signals can be utilized by neoplastic cells...
  53. SURGICAL HEPATECTOMY--PROLACTIN INITIATES MITOGENESIS
    CHARLES PUTNAM; Fiscal Year: 1993
    After surgical hepatectomy, the remaining hepatic tissue quickly and efficiently proliferates, reconstituting the normal liver mass...
  54. ETHANOL AND IL6 SIGNAL TRANSDUCTION
    Bin Gao; Fiscal Year: 1999
    ..In animal models, acute or chronic exposure to ethanol impairs liver regeneration following partial hepatectomy or chemically induced liver injury, but the mechanisms by which ethanol inhibits liver regeneration are still ..
  55. Ceramide & capacity for growth in aging: a liver aspect
    Mariana Nikolova Karakashian; Fiscal Year: 2001
    ..capacitation is achieved by disruption of cell- cell contacts during different injury models, such as partial hepatectomy or collagenase perfusion...
  56. Foxm 1b endocrine pancreas growth and regeneration
    Maureen Gannon; Fiscal Year: 2009
    ..Liver-specific Foxml inactivation impairs liver regeneration following partial hepatectomy. These results prompted us to examine whether Foxml functions similarly in pancreas and/or 3 cell regeneration ..
  57. HEPATIC CARCINOGENESIS: MOLECULAR MECHANISMS
    Martina Buck; Fiscal Year: 2006
    ..hepatocytes are quiescent yet have the ability to proliferate in response to hepatocellular injury, partial hepatectomy and growth mediators, such as transforming growth factor alpha (TGFalpha)...
  58. LIVER REGENERATION AS A MODEL FOR ANGIOGENESIS
    Donna Stolz; Fiscal Year: 2002
    ..The model of liver regeneration in the rat following 70% partial hepatectomy (PHx) provides a hitherto unexploited system by which to dissect the phenomenon of controlled angiogenesis...
  59. Hepatocyte Nuclear Factors in Regenerating Liver
    ANGELA TYNER; Fiscal Year: 2007
    ..of the few adult organs capable of completely regenerating itself in response to injury or two-thirds partial hepatectomy in which terminally differentiated hepatocytes are induced to reenter the cell cycle and undergo DNA ..
  60. CYTOKINES AND LIVER GROWTH BY PEROXISOME PROLIFERATORS
    LINDA GREENBAUM; Fiscal Year: 1999
    ..are important for liver cell proliferation in compensatory liver growth models including the rodent partial hepatectomy model have been extensively characterized, the molecular basis for liver cell proliferation in response to ..
  61. ERROR-PRONE DNA REPAIR IN HEPATOCARCINOGENESIS
    JAMES YAGER; Fiscal Year: 1980
    ..at various doses and times relative to enhanced liver DNA synthesis caused by surgical partial hepatectomy. The doses and times will be sufficient to cause varying degrees of short-term inhibition of regenerative DNA ..
  62. AFP GENE EXPRESSION AND CARCINOGENESIS
    Stewart Sell; Fiscal Year: 1990
    ..under certain abnormal conditions, such as during hepatocarcinogenesis and in regeneration of a partial hepatectomy. The AFP gene is also active in some transplantable hepatocellular carcinomas (hepatomas), and in cell lines ..
  63. GROWTH FACTOR MODULATION OF LIVER GROWTH AND REPAIR
    William Russell; Fiscal Year: 1993
    ..both stimulatory and inhibitory growth factors are present in non-regenerating liver, and propose that partial hepatectomy (PH) alters the cell types that produce and respond to these factors and thereby alters the balance between ..
  64. ALPHA-1 ADRENORECEPTOR, RAS P21, AND LIVER REGENERATION
    JENNIFER CRUISE; Fiscal Year: 1990
    ..receptor is also involved in the early stimulation of regenerative DNA synthesis in rat liver after 2/3 partial hepatectomy. At a crucial time in the prereplicative phase, the alpha 1 receptor is uncoupled from turnover of membrane ..
  65. Foxm1b and HNF-6 regulation of liver injury response
    Ai Xuan Holterman; Fiscal Year: 2006
    ..the expression of S-and M-phase cell cycle genes, hepatocyte proliferation is accelerated during partial hepatectomy. Following bile duct ligation (BDL), bile duct cell proliferation is associated with reduced expression of ..