colonoscopy

Summary

Summary: Endoscopic examination, therapy or surgery of the luminal surface of the colon.

Top Publications

  1. pmc Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths
    Ann G Zauber
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    N Engl J Med 366:687-96. 2012
  2. doi Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 58:130-60. 2008
  3. ncbi Polyp miss rate determined by tandem colonoscopy: a systematic review
    Jeroen C van Rijn
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Am J Gastroenterol 101:343-50. 2006
  4. ncbi CT colonography versus colonoscopy for the detection of advanced neoplasia
    David H Kim
    Department of Radiology, University of Wisconsin Medical School, Madison 53792 3252, USA
    N Engl J Med 357:1403-12. 2007
  5. doi Protection from colorectal cancer after colonoscopy: a population-based, case-control study
    Hermann Brenner
    German Cancer Research Center, University Clinic Heidelberg, University of Heidelberg, Germany
    Ann Intern Med 154:22-30. 2011
  6. pmc Accuracy of CT colonography for detection of large adenomas and cancers
    C Daniel Johnson
    Mayo Clinic Arizona, Scottsdale, AZ, USA
    N Engl J Med 359:1207-17. 2008
  7. doi American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]
    Douglas K Rex
    Indiana University Medical Center, IU Hospital, Indianapolis 46202, USA
    Am J Gastroenterol 104:739-50. 2009
  8. doi Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010
  9. doi Asia Pacific consensus recommendations for colorectal cancer screening
    J J Y Sung
    The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gut 57:1166-76. 2008
  10. ncbi Quality indicators for colonoscopy
    Douglas K Rex
    Am J Gastroenterol 101:873-85. 2006

Detail Information

Publications368 found, 100 shown here

  1. pmc Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths
    Ann G Zauber
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    N Engl J Med 366:687-96. 2012
    ..In the National Polyp Study (NPS), colorectal cancer was prevented by colonoscopic removal of adenomatous polyps. We evaluated the long-term effect of colonoscopic polypectomy in a study on mortality from colorectal cancer...
  2. doi Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 58:130-60. 2008
    ..It is the strong opinion of these 3 organizations that colon cancer prevention should be the primary goal of screening...
  3. ncbi Polyp miss rate determined by tandem colonoscopy: a systematic review
    Jeroen C van Rijn
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Am J Gastroenterol 101:343-50. 2006
    b>Colonoscopy is the best available method to detect and remove colonic polyps and therefore serves as the gold standard for less invasive tests such as virtual colonoscopy...
  4. ncbi CT colonography versus colonoscopy for the detection of advanced neoplasia
    David H Kim
    Department of Radiology, University of Wisconsin Medical School, Madison 53792 3252, USA
    N Engl J Med 357:1403-12. 2007
    Advanced neoplasia represents the primary target for colorectal-cancer screening and prevention. We compared the diagnostic yield from parallel computed tomographic colonography (CTC) and optical colonoscopy (OC) screening programs.
  5. doi Protection from colorectal cancer after colonoscopy: a population-based, case-control study
    Hermann Brenner
    German Cancer Research Center, University Clinic Heidelberg, University of Heidelberg, Germany
    Ann Intern Med 154:22-30. 2011
    b>Colonoscopy with detection and removal of adenomas is considered a powerful tool to reduce colorectal cancer (CRC) incidence...
  6. pmc Accuracy of CT colonography for detection of large adenomas and cancers
    C Daniel Johnson
    Mayo Clinic Arizona, Scottsdale, AZ, USA
    N Engl J Med 359:1207-17. 2008
    ..Computed tomographic (CT) colonography is a noninvasive option in screening for colorectal cancer. However, its accuracy as a screening tool in asymptomatic adults has not been well defined...
  7. doi American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]
    Douglas K Rex
    Indiana University Medical Center, IU Hospital, Indianapolis 46202, USA
    Am J Gastroenterol 104:739-50. 2009
    ..The CRC screening tests are now grouped into cancer prevention tests and cancer detection tests. Colonoscopy every 10 years, beginning at age 50, remains the preferred CRC screening strategy...
  8. doi Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010
    b>Colonoscopy is used for early detection and prevention of colorectal cancer, but evidence on the magnitude of overall protection and protection according to anatomical site through colonoscopy performed in the community setting is sparse...
  9. doi Asia Pacific consensus recommendations for colorectal cancer screening
    J J Y Sung
    The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gut 57:1166-76. 2008
    ..Faecal occult blood test (FOBT, guaiac-based and immunochemical tests), flexible sigmoidoscopy and colonoscopy are recommended for CRC screening. Double-contrast barium enema and CT colonography are not preferred...
  10. ncbi Quality indicators for colonoscopy
    Douglas K Rex
    Am J Gastroenterol 101:873-85. 2006
  11. doi Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection
    Eero Mattila
    Department of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland
    Gastroenterology 142:490-6. 2012
    ..Treatment of recurrent Clostridium difficile infection (CDI) with antibiotics leads to recurrences in up to 50% of patients. We investigated the efficacy of fecal transplantation in treatment of recurrent CDI...
  12. doi Factors determining the quality of screening colonoscopy: a prospective study on adenoma detection rates, from 12,134 examinations (Berlin colonoscopy project 3, BECOP-3)
    Andreas Adler
    Central Interdisciplinary Endoscopy, Charité Medical University, Campus Virchow Hospital, Berlin, Germany
    Gut 62:236-41. 2013
    Screening colonoscopy (SC) outcome quality is best determined by the adenoma detection rate (ADR). The substantial variability in the ADRs between endoscopists may reflect different skills, experience and/or equipment.
  13. pmc Efficacy in standard clinical practice of colonoscopic polypectomy in reducing colorectal cancer incidence
    F Citarda
    Regina Elena Cancer Institute, Rome, Italy
    Gut 48:812-5. 2001
    ..aged 40-69 years, enrolled between 1980 and 1987 following a total colon examination (TCE) (that is, total colonoscopy or colonoscopy and double contrast barium enema), with removal of at least one adenoma larger than 5 mm in ..
  14. ncbi A randomized trial of aspirin to prevent colorectal adenomas
    John A Baron
    Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    N Engl J Med 348:891-9. 2003
    ..Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel...
  15. ncbi High yields of small and flat adenomas with high-definition colonoscopes using either white light or narrow band imaging
    Douglas K Rex
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastroenterology 133:42-7. 2007
    Detection of adenomas is an important goal of colonoscopy. Narrow band imaging (NBI) might highlight adenomas and lead to higher rates of adenoma detection.
  16. ncbi Location of adenomas missed by optical colonoscopy
    Perry J Pickhardt
    Department of Radiology, University of Wisconsin Medical School, E3 311 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792 3252, USA
    Ann Intern Med 141:352-9. 2004
    Previous estimates of the adenoma miss rate with optical colonoscopy (OC) are hindered by the use of OC as its own reference standard.
  17. ncbi Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society
    Sidney J Winawer
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Gastroenterology 130:1872-85. 2006
    ..In 2003 these guidelines were updated and colonoscopy was recommended as the only follow-up examination, stratification at baseline into low risk and higher risk for ..
  18. ncbi Association of colonoscopy and death from colorectal cancer
    Nancy N Baxter
    Li Ka Shing Knowledge Institute, St Michael s Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 150:1-8. 2009
    b>Colonoscopy is advocated for screening and prevention of colorectal cancer (CRC), but randomized trials supporting the benefit of this practice are not available.
  19. doi Analysis of administrative data finds endoscopist quality measures associated with postcolonoscopy colorectal cancer
    Nancy N Baxter
    Department of Surgery and Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 140:65-72. 2011
    Most quality indicators for colonoscopy measure processes; little is known about their relationship to patient outcomes...
  20. ncbi Colonoscopic withdrawal times and adenoma detection during screening colonoscopy
    Robert L Barclay
    Rockford Gastroenterology Associates, IL 61107, USA
    N Engl J Med 355:2533-41. 2006
    b>Colonoscopy is commonly used to screen for neoplasia...
  21. doi Miss rate for colorectal neoplastic polyps: a prospective multicenter study of back-to-back video colonoscopies
    D Heresbach
    Department of Gastroenterology, Hospital Pontchaillou, Rennes, France
    Endoscopy 40:284-90. 2008
    Polyp miss rates during colonoscopy have been calculated in a few tandem or back-to-back colonoscopy studies. Our objective was to assess the adenoma miss rate while limiting technique or operator expertise biases, i. e...
  22. doi Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)
    Stuart R Cairns
    Digestive Diseases Centre, Brighton and Sussex University Hospitals, Royal Sussex County Hospital, Eastern Road, Brighton, UK
    Gut 59:666-89. 2010
    ..In other areas guidance is relatively unchanged, but the recent literature was reviewed and is included where appropriate...
  23. doi Efficacy of a nationwide screening colonoscopy program for colorectal cancer
    Christian P Pox
    Department of Medicine, Ruhr Universitat Bochum, Knappschaftskrankenhaus, Bochum, Germany
    Gastroenterology 142:1460-7.e2. 2012
    Screening colonoscopy examinations for colorectal cancer are offered in the United States and some European countries. Data on results and adverse effects of screening colonoscopy are limited...
  24. doi Screening colonoscopy for colorectal cancer in asymptomatic people: a meta-analysis
    Yaron Niv
    Department of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, 49100, Israel
    Dig Dis Sci 53:3049-54. 2008
    The preferred method for screening asymptomatic people for colorectal cancer (CRC) is colonoscopy, according to the new American guidelines...
  25. doi Prevalence and variable detection of proximal colon serrated polyps during screening colonoscopy
    Charles J Kahi
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Gastroenterol Hepatol 9:42-6. 2011
    b>Colonoscopy may have a greater protective effect for distal colorectal cancer (CRC) than proximal CRC. Serrated polyps are frequently located in the proximal colon, can be missed during colonoscopy, and may progress to CRC...
  26. doi Results from the first three rounds of the Scottish demonstration pilot of FOBT screening for colorectal cancer
    R J C Steele
    Department of Surgery, University of Dundee, Dundee, UK
    Gut 58:530-5. 2009
    ..To assess the effects of the first three rounds of a pilot colorectal screening programme based on guaiac faecal occult blood testing (gFOBT) and their implications for a national population-based programme...
  27. ncbi Appearance of enhanced tissue features in narrow-band endoscopic imaging
    Kazuhiro Gono
    Olympus Co, Ishikawa cho, Hachioji shi, Tokyo 192 8507, Japan
    J Biomed Opt 9:568-77. 2004
    ..The results of clinical tests in colonoscopy and esophagoscopy indicated that NBI will be useful as a supporting method for observation of the endoscopic ..
  28. ncbi Diagnosis and management of dysplasia in patients with inflammatory bowel diseases
    Steven H Itzkowitz
    The Dr Henry D Janowitz Division of Gastroenterology, Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 126:1634-48. 2004
    ..The main objective of regular colonoscopy is to detect neoplasia at a surgically curative and preferably preinvasive stage, i.e., dysplasia...
  29. ncbi Activation of the mucosal immune system in irritable bowel syndrome
    Vinton S Chadwick
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, New Zealand
    Gastroenterology 122:1778-83. 2002
    ..A role for the mucosal immune system in the pathogenesis of irritable bowel syndrome is suggested by its association with intestinal infections...
  30. pmc Screening for colorectal cancer: random comparison of guaiac and immunochemical faecal occult blood testing at different cut-off levels
    L Hol
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Br J Cancer 100:1103-10. 2009
    ..testing (FIT) provides quantitative test results, which allows optimisation of the cut-off value for follow-up colonoscopy. We conducted a randomised population-based trial to determine test characteristics of FIT (OC-Sensor micro, ..
  31. ncbi Maximizing detection of adenomas and cancers during colonoscopy
    Douglas K Rex
    Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 101:2866-77. 2006
    Some patients who undergo colonoscopy that appeared to have cleared the colorectum of neoplasia return within a short interval (1-3 yr) with colorectal cancer...
  32. doi Colonoscopy quality measures: experience from the NHS Bowel Cancer Screening Programme
    Thomas J W Lee
    University Hospital of North Tees, Stockton on Tees, UK
    Gut 61:1050-7. 2012
    b>Colonoscopy is central to colorectal cancer (CRC) screening. Success of CRC screening is dependent on colonoscopy quality...
  33. doi Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial
    Esther M Stoop
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, Netherlands
    Lancet Oncol 13:55-64. 2012
    Screening for colorectal cancer is widely recommended, but the preferred strategy remains unidentified. We aimed to compare participation and diagnostic yield between screening with colonoscopy and with non-cathartic CT colonography.
  34. doi Colonoscopy and fecal occult blood test use in Germany: results from a large insurance-based cohort
    C Stock
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Endoscopy 43:771-81. 2011
    b>Colonoscopy and guaiac-based fecal occult blood tests (FOBT) are recommended and offered for colorectal cancer (CRC) screening in Germany. We aimed to explore their utilization in a large insurance-based cohort.
  35. pmc Effect of rising chemotherapy costs on the cost savings of colorectal cancer screening
    Iris Lansdorp-Vogelaar
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Natl Cancer Inst 101:1412-22. 2009
    ..We examined whether colorectal cancer screening would become cost saving with the widespread use of the newer, more expensive chemotherapies...
  36. doi Prevalence of missed adenomas in patients with inadequate bowel preparation on screening colonoscopy
    Reena V Chokshi
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA
    Gastrointest Endosc 75:1197-203. 2012
    The prevalence of missed polyps in patients with inadequate bowel preparation on screening colonoscopy is unknown.
  37. doi Acceptability and side-effects of colonoscopy and sigmoidoscopy in a screening setting
    Carlo Senore
    Centro Prevenzione Oncologica Regione Piemonte and Azienda Ospedaliero Universitaria S Giovanni Battista di Torino, V San Francesco da Paola 31, 10123 Torino, Italy
    J Med Screen 18:128-34. 2011
    ..Quantitative information on adverse reactions associated with colorectal cancer (CRC) screening tests is useful to estimate the balance between benefit and risk in different strategies...
  38. doi High definition colonoscopy combined with i-Scan is superior in the detection of colorectal neoplasias compared with standard video colonoscopy: a prospective randomized controlled trial
    A Hoffman
    I Med Clinic, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    Endoscopy 42:827-33. 2010
    b>Colonoscopy is the accepted gold standard for the detection of colorectal cancer. The aim of the current study was to prospectively compare high definition plus (HD+) colonoscopy with I-Scan functionality (electronic staining) vs...
  39. ncbi Colonoscopic screening of average-risk women for colorectal neoplasia
    Philip Schoenfeld
    Division of Gastroenterology, University of Michigan School of Medicine and Veterans Affairs Center for Excellence in Health Services Research, Ann Arbor 48105, USA
    N Engl J Med 352:2061-8. 2005
    ..villous adenomas, adenomas with high-grade dysplasia, or cancer) in men would be missed with the use of flexible sigmoidoscopy but detected by colonoscopy. In a tandem study, we examined the yield of screening colonoscopy in women.
  40. doi Randomized, controlled trial of standard-definition white-light, high-definition white-light, and narrow-band imaging colonoscopy for the detection of colon polyps and prediction of polyp histology
    Amit Rastogi
    University of Kansas School of Medicine, Veterans Affairs Medical Center, Kansas City, Missouri 64128 2295, USA
    Gastrointest Endosc 74:593-602. 2011
    Missing adenomas and the inability to accurately differentiate between polyp histology remain the main limitations of standard-definition white-light (SD-WL) colonoscopy.
  41. doi Association between colonoscopy rates and colorectal cancer mortality
    Linda Rabeneck
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Gastroenterol 105:1627-32. 2010
    Although colonoscopy use has increased in the United States and Canada since the early 1990s, it is unclear whether this has been associated with benefit at the population level...
  42. pmc The impact of suboptimal bowel preparation on adenoma miss rates and the factors associated with early repeat colonoscopy
    Benjamin Lebwohl
    Department of Medicine, Division of Digestive and Liver Diseases, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Gastrointest Endosc 73:1207-14. 2011
    There are no guidelines for the recommended interval to the next examination after colonoscopy with suboptimal bowel preparation.
  43. pmc Utilization and yield of surveillance colonoscopy in the continued follow-up study of the polyp prevention trial
    Adeyinka O Laiyemo
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Gastroenterol Hepatol 7:562-7; quiz 497. 2009
    Prospective information on the use and yield of surveillance colonoscopy is limited...
  44. doi High accuracy of narrow band imaging without magnification for the real-time characterization of polyp histology and its comparison with high-definition white light colonoscopy: a prospective study
    Amit Rastogi
    Division of Gastroenterology and Hepatology, University of Kansas School of Medicine, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    Am J Gastroenterol 104:2422-30. 2009
    Standard white light colonoscopy has limited ability to differentiate between polyp types (adenomatous vs. hyperplastic)...
  45. doi Sex-specific prevalence of adenomas, advanced adenomas, and colorectal cancer in individuals undergoing screening colonoscopy
    Monika Ferlitsch
    Quality Assurance Working Group, Austrian Society for Gastroenterology and Hepatology, Vienna, Austria
    JAMA 306:1352-8. 2011
    Although some studies have shown that men are at greater age-specific risk for advanced colorectal neoplasia than women, the age for referring patients to screening colonoscopy is independent of sex and usually recommended to be 50 years.
  46. pmc Effect of repeated invitations on uptake of colorectal cancer screening using faecal occult blood testing: analysis of prevalence and incidence screening
    R J C Steele
    Department of Surgery, University of Dundee, UK
    BMJ 341:c5531. 2010
    ..To analyse the effects of prevalence and incidence screening on uptake and detection of cancer in an ongoing, dynamic programme for colorectal screening using faecal occult blood testing...
  47. doi High-definition chromocolonoscopy vs. high-definition white light colonoscopy for average-risk colorectal cancer screening
    Charles J Kahi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 105:1301-7. 2010
    ..High-definition chromoscopy is used to increase the yield of colonoscopy for flat and depressed neoplasms; however, its role in average-risk patients undergoing routine screening ..
  48. ncbi Rates of new or missed colorectal cancers after colonoscopy and their risk factors: a population-based analysis
    Brian Bressler
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 132:96-102. 2007
    The rate of new or missed colorectal cancer (CRC) after colonoscopy and their risk factors in usual practice are unknown. Our objective was to evaluate the rate and risk factors in a population-based study.
  49. ncbi Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopies
    Harminder Singh
    Department of Internal Medicine, Cancer Care Manitoba, University of Manitoba, Winnipeg
    JAMA 295:2366-73. 2006
    Limited evidence exists to guide the optimal frequency of repeat endoscopic examination for colorectal cancer screening after a negative colonoscopy.
  50. pmc Surveillance guidelines after removal of colorectal adenomatous polyps
    W S Atkin
    Cancer Research UK, Colorectal Cancer Unit, St Mark s Hospital, Harrow, Middlesex HA1 3UJ, UK
    Gut 51:V6-9. 2002
  51. doi Quality indicators for colonoscopy and the risk of interval cancer
    Michal F Kaminski
    Department of Gastroenterology, Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    N Engl J Med 362:1795-803. 2010
    ..of detection of adenomatous lesions (tumors or polyps) and cecal intubation are recommended for use as quality indicators for screening colonoscopy, these measurements have not been validated, and their importance remains uncertain.
  52. ncbi A comparison of the immunochemical fecal occult blood test and total colonoscopy in the asymptomatic population
    Tamiya Morikawa
    Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Japan
    Gastroenterology 129:422-8. 2005
    ..The aim of this study was to analyze the sensitivity of immunochemical FOBT and to compare the results with the findings from complete colonoscopy.
  53. pmc Colorectal cancer: CT colonography and colonoscopy for detection--systematic review and meta-analysis
    Perry J Pickhardt
    Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3 311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3252, USA
    Radiology 259:393-405. 2011
    To perform a systematic review and meta-analysis of published studies assessing the sensitivity of both computed tomographic (CT) colonography and optical colonoscopy (OC) for colorectal cancer detection.
  54. ncbi Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European Panel of Appropriateness of Gastrointestinal Endoscopy European multicenter study
    Florian Froehlich
    Department of Gastroenterology PMU CHUV, Institute of Social and Preventive Medicine, University of Lausanne, Rue du Bugnon 44, CH 1011 Lausanne, Switzerland
    Gastrointest Endosc 61:378-84. 2005
    The quality of colon cleansing is a major determinant of quality of colonoscopy. To our knowledge, the impact of bowel preparation on the quality of colonoscopy has not been assessed prospectively in a large multicenter study...
  55. ncbi Long term outcome of patients with active Crohn's disease exhibiting extensive and deep ulcerations at colonoscopy
    Matthieu Allez
    Service de Gastroenterologie, Hopital Saint Louis, Paris, France
    Am J Gastroenterol 97:947-53. 2002
    ..Prediction of the clinical course of Crohn's disease (CD) is difficult in the long term. Our aim was to determine whether the presence of severe endoscopic lesions (SELs) may predict a higher risk of colectomy and penetrating complications...
  56. pmc Detecting diminutive colorectal lesions at colonoscopy: a randomised controlled trial of pan-colonic versus targeted chromoscopy
    D P Hurlstone
    Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK
    Gut 53:376-80. 2004
    ..Previous data have suggested that pan-chromoscopy may improve detection rates. No randomised control trial has been performed examining detection rates of such lesions while controlling for extubation time and lavage effect...
  57. ncbi ASGE guideline: colorectal cancer screening and surveillance
    Raquel E Davila
    American Society for Gastrointestinal Endoscopy, 1520 Kensington Road, Ste 202, Oak Brook, IL 60523, USA
    Gastrointest Endosc 63:546-57. 2006
  58. ncbi Colorectal cancer in patients under close colonoscopic surveillance
    Douglas J Robertson
    Section of Gastroenterology, VA Medical Center, White River Junction, Vermont 05009, USA
    Gastroenterology 129:34-41. 2005
    ..We determined the incidence of CRC in patients under colonoscopic surveillance and examined the circumstances and risk factors for CRC and adenoma with high-grade dysplasia...
  59. ncbi Barriers to colorectal cancer screening among Medicare consumers
    Carrie N Klabunde
    Health Services and Economics Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Am J Prev Med 30:313-9. 2006
    ..Few studies have examined lack of physician recommendation and other reasons for under-utilization of colorectal cancer (CRC) screening in the Medicare population...
  60. ncbi The impact of colon cleanliness assessment on endoscopists' recommendations for follow-up colonoscopy
    Shomron Ben-Horin
    Department of Gastroenterology, Sheba Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Am J Gastroenterol 102:2680-5. 2007
    Repeat colonoscopy is advocated for low-quality preparations. However, there are few data on how endoscopists assess the quality of bowel preparation...
  61. ncbi The advanced adenoma as the primary target of screening
    Sidney J Winawer
    Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Medical College of Cornell University, New York, New York 10021, USA
    Gastrointest Endosc Clin N Am 12:1-9, v. 2002
    ....
  62. pmc Trends in colorectal cancer test use among vulnerable populations in the United States
    Carrie N Klabunde
    Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
    Cancer Epidemiol Biomarkers Prev 20:1611-21. 2011
    ..This study examines recent national trends in CRC test use, including among vulnerable populations...
  63. ncbi Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer
    Douglas K Rex
    Department of Medicine Gastroenterology, Indiana University Medical Center, Indianapolis, USA
    Am J Gastroenterol 97:1296-308. 2002
  64. doi Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening
    Enrique Quintero
    Department of Gastroenterology, Hospital Universitario de Canarias, Tenerife, Spain
    N Engl J Med 366:697-706. 2012
    b>Colonoscopy and fecal immunochemical testing (FIT) are accepted strategies for colorectal-cancer screening in the average-risk population.
  65. ncbi Colorectal cancer screening: scientific review
    Judith M E Walsh
    Division of General Internal Medicine, Department of Medicine, Women s Health Clinical Research Center, University of California San Francisco, Campus Box 1793, 1635 Divisadero Suite 600, San Francisco, CA 94115, USA
    JAMA 289:1288-96. 2003
    ..Clinicians are challenged to ensure that eligible patients undergo colorectal cancer screening and to guide patients in choosing what tests to receive...
  66. doi Proximal and large hyperplastic and nondysplastic serrated polyps detected by colonoscopy are associated with neoplasia
    Mitchal A Schreiner
    Portland VA Medical Center and Oregon Health and Science University, Portland, Oregon, USA
    Gastroenterology 139:1497-502. 2010
    ..We investigated whether detection of proximal nondysplastic serrated polyps (ND-SP) at screening and surveillance colonoscopies is associated with advanced neoplasia...
  67. ncbi Quality indicators for colonoscopy
    Douglas K Rex
    ASGE Communications Department, 1520 Kensington Road, Suite 202, Oak Brook, IL 60523, USA
    Gastrointest Endosc 63:S16-28. 2006
  68. doi Computed virtual chromoendoscopy versus standard colonoscopy with targeted indigocarmine chromoscopy: a randomised multicentre trial
    J Pohl
    Department of Internal Medicine II, Dr Horst Schmidt Klinik, Weisbaden, Germany
    Gut 58:73-8. 2009
    b>Colonoscopy is the accepted gold standard for screening of neoplastic colorectal lesions, but the substantial miss rate remains a challenge...
  69. doi Higher adenoma detection rates with cap-assisted colonoscopy: a randomised controlled trial
    Amit Rastogi
    Gastroenterology and Hepatology, Veterans Affairs Medical Center, Kansas City, Missouri 64128 2295, USA
    Gut 61:402-8. 2012
    Cap-assisted colonoscopy (CAC) uses a small plastic transparent cap attached to the tip of the colonoscope that can depress and flatten colonic folds and thus improve visualisation of their proximal aspects...
  70. ncbi The use of screening colonoscopy for patients cared for by the Department of Veterans Affairs
    Hashem B El-Serag
    Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Intern Med 166:2202-8. 2006
    Medicare data indicate an increase in colorectal cancer (CRC) screening using colonoscopy and a decline in fecal occult blood testing, flexible sigmoidoscopy, and double-contrast barium enema...
  71. pmc Physician and patient factors associated with ordering a colon evaluation after a positive fecal occult blood test
    Barbara Turner
    Division of General Internal Medicine BT, University of Pennsylvania, Philadelphia, PA, USA
    J Gen Intern Med 18:357-63. 2003
    Successful colorectal cancer screening relies in part on physicians ordering a complete diagnostic evaluation of the colon (CDE) with colonoscopy or barium enema plus sigmoidoscopy after a positive screening fecal occult blood test (FOBT).
  72. doi Narrow-band imaging without high magnification to differentiate polyps during real-time colonoscopy: improvement with experience
    Jason N Rogart
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    Gastrointest Endosc 68:1136-45. 2008
    There is no widely adopted, easily applied method for distinguishing between adenomatous and nonadenomatous polyps during real-time colonoscopy.
  73. doi High colonoscopic prevalence of proximal colon serrated polyps in average-risk men and women
    Charles J Kahi
    Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastrointest Endosc 75:515-20. 2012
    Proximal colon serrated polyps likely contribute to the decreased protection of colonoscopy against right-sided colorectal cancer.
  74. pmc Screening colonoscopy and risk for incident late-stage colorectal cancer diagnosis in average-risk adults: a nested case-control study
    Chyke A Doubeni
    Department of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Gates 2, Philadelphia, PA 19104, USA
    Ann Intern Med 158:312-20. 2013
    The effectiveness of screening colonoscopy in average-risk adults is uncertain, particularly for right colon cancer.
  75. doi Value of magnifying endoscopy in classifying colorectal polyps based on vascular pattern
    J J W Tischendorf
    Department of Gastroenterology, Hepatology and Metabolic Diseases, University Hospital Aachen, D 52074 Aachen, Germany
    Endoscopy 42:22-7. 2010
    ..The aim of this study was to evaluate the diagnostic accuracy of NBI endoscopy with and without high magnification for the differentiation of neoplastic from non-neoplastic colorectal polyps...
  76. ncbi Terminal ileal photography or biopsy to verify total colonoscopy: does the endoscope agree with the microscope?
    Nick Powell
    Department of Gastroenterology, Queen Elizabeth Hospital, Woolwich, London, UK
    Gastrointest Endosc 66:320-5. 2007
    Various modalities exist to document the extent of colonoscopy, including a terminal ileum (TI) biopsy, which is considered the criterion standard by some authorities...
  77. doi Diagnosis of depth of invasion for early colorectal cancer using magnifying colonoscopy
    Hisatomo Ikehara
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 25:905-12. 2010
    ..m.-d.) invasion should not be treated with endoscopic mucosal resection due to the higher incidence of lymph-node metastasis. It is, therefore, clinically important to accurately diagnose s.m.-d. lesions before treatment...
  78. doi Narrow-band imaging magnification predicts the histology and invasion depth of colorectal tumors
    Hiroyuki Kanao
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Gastrointest Endosc 69:631-6. 2009
    ..There are several reports concerning the differential diagnosis of non-neoplastic and neoplastic colorectal lesions by narrow-band imaging (NBI). However, there are only a few NBI articles that assessed invasion depth...
  79. doi Prevalence of advanced histological features in diminutive and small colon polyps
    Neil Gupta
    Division of Gastroenterology, Kansas City Veterans Affairs Medical Center, Kansas City, Missouri, USA
    Gastrointest Endosc 75:1022-30. 2012
    ..resect, and discard" strategies for diminutive (≤ 5 mm) or small (6-9 mm) polyps to reduce screening colonoscopy costs...
  80. doi Cap-fitted colonoscopy: a randomized, tandem colonoscopy study of adenoma miss rates
    David G Hewett
    Division of Gastroenterology Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastrointest Endosc 72:775-81. 2010
    Failures of adenoma detection diminish the effectiveness of colonoscopy.
  81. pmc Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer
    Andrea N Burnett-Hartman
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Am J Gastroenterol 107:1213-9. 2012
    b>Colonoscopy is associated with a decreased risk of colorectal cancer but may be more effective in reducing the risk of distal than proximal malignancies...
  82. doi Cost-effectiveness of mass screening for colorectal cancer: choice of fecal occult blood test and screening strategy
    Iradj Sobhani
    Gastroenterology Unit, Albert Chenevier Henri Mondor Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Dis Colon Rectum 54:876-86. 2011
    ..A positive test selects those who should undergo colonoscopy to ensure early detection of colorectal cancer. Guaiac fecal occult blood test has low sensitivity...
  83. doi Cost-effectiveness analysis of a quantitative immunochemical test for colorectal cancer screening
    Janneke A Wilschut
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Gastroenterology 141:1648-55.e1. 2011
    ..We aimed to identify the most cost-effective FIT cutoff level for referral to colonoscopy based on data from these trials and allowing for differences in screening ages.
  84. doi Patients' experiences and reported barriers to colonoscopy in the screening context--a systematic review of the literature
    Sue Anne McLachlan
    Oncology Department, St Vincent s Hospital, Melbourne, Australia
    Patient Educ Couns 86:137-46. 2012
    A systematic review of the literature was conducted to characterise patients' own experience of colonoscopy in the screening context.
  85. doi Accuracy of in vivo optical diagnosis of colon polyp histology by narrow-band imaging in predicting colonoscopy surveillance intervals
    Neil Gupta
    Division of Gastroenterology, Kansas City Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA
    Gastrointest Endosc 75:494-502. 2012
    ..Narrow-band imaging (NBI) has been shown to predict polyp histology with moderate to high accuracy in several studies...
  86. ncbi Risk stratification for colon neoplasia: screening strategies using colonoscopy and computerized tomographic colonography
    Otto S Lin
    Gastroenterology Section, Virginia Mason Medical Center, 1100 Ninth Avenue, Seattle, WA 98101, USA
    Gastroenterology 131:1011-9. 2006
    We developed a risk index to identify low-risk patients who may be screened for colorectal cancer with computerized tomographic colonography (CTC) instead of colonoscopy.
  87. pmc Diagnostic value of CT-colonography as compared to colonoscopy in an asymptomatic screening population: a meta-analysis
    Margriet C de Haan
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Radiol 21:1747-63. 2011
    ..Previous meta-analyses on CT-colonography included both average and high risk individuals, which may overestimate the diagnostic value in screening. A meta-analysis was performed to obtain the value of CT-colonography for screening...
  88. doi Accuracy for optical diagnosis of small colorectal polyps in nonacademic settings
    Teaco Kuiper
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Gastroenterol Hepatol 10:1016-20; quiz e79. 2012
    ..We performed a prospective study to assess the accuracy of optical diagnosis of small colorectal polyps in a nonacademic setting (the DISCOUNT trial) by using high-resolution endoscopy (HRE) and narrow-band imaging (NBI)...
  89. doi The Asia-Pacific Colorectal Screening score: a validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects
    Khay Guan Yeoh
    Department of Medicine, National University of Singapore
    Gut 60:1236-41. 2011
    ..To develop and validate a clinical risk score predictive of risk for colorectal advanced neoplasia for Asia...
  90. ncbi Validity of self-reported colorectal cancer screening behavior
    M Baier
    American Medical Center Cancer Research Center, Lakewood, Colorado 80214, USA
    Cancer Epidemiol Biomarkers Prev 9:229-32. 2000
    ..Cases who had received a fecal occult blood test (FOBT), flexible sigmoidoscopy, and/or colonoscopy, and controls who had no record of colorectal screening were identified among 40-75-year-old members of the ..
  91. doi Development and validation of a training module on the use of narrow-band imaging in differentiation of small adenomas from hyperplastic colorectal polyps
    Ana Ignjatovic
    Wolfson Unit for Endoscopy, St Mark s Hospital, Harrow, Middlesex, United Kingdom
    Gastrointest Endosc 73:128-33. 2011
    Experts are accurate in differentiating small adenomas from hyperplastic polyps at colonoscopy by using narrow-band imaging (NBI).
  92. doi Ascertainment of colonoscopy indication using administrative data
    Deborah A Fisher
    Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC, USA
    Dig Dis Sci 55:1721-5. 2010
    Administrative procedure code data can estimate colonoscopy utilization; however, determining colonoscopy indication is more difficult as procedure codes do not inherently reflect the purpose (screening, surveillance, diagnosis) of the ..
  93. doi Double-balloon endoscopy versus magnet-imaging enhanced colonoscopy for difficult colonoscopies, a randomized study
    T Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Endoscopy 44:38-42. 2012
    Studies have estimated that failure of cecal intubation occurs with conventional colonoscopy in up to 10 % of cases...
  94. doi Diagnostic accuracy of narrow-band imaging for the differentiation of neoplastic from non-neoplastic colorectal polyps: a meta-analysis
    L Wu
    Department of Colorectal and Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China
    Colorectal Dis 15:3-11. 2013
    ..However, the real accuracy for the differentiation of neoplastic from non-neoplastic polyps by NBI for the colorectum is still unknown...
  95. pmc Utilization of surveillance colonoscopy in community practice
    Robert E Schoen
    Department of Medicine, University of Pittsburgh Medical Center, and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 2582, USA
    Gastroenterology 138:73-81. 2010
    The recommended timing of surveillance colonoscopy for individuals with adenomatous polyps is based on adenoma histology, size, and number. The burden and cost of surveillance colonoscopy are significant...
  96. pmc Low adherence to colonoscopy in the screening of first-degree relatives of patients with colorectal cancer
    Luis Bujanda
    Department of Gastroenterology, Donostia Hospital, San Sebastian, Spain
    Gut 56:1714-8. 2007
    b>Colonoscopy is one of the methods of choice for screening relatives of patients with colorectal cancer.
  97. ncbi Memories of colonoscopy: a randomized trial
    Donald A Redelmeier
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Pain 104:187-94. 2003
    ..We studied consecutive outpatients undergoing colonoscopy who were medically stable, mentally competent, and able to speak English (n=682)...
  98. doi Computer-aided classification of colorectal polyps based on vascular patterns: a pilot study
    J J W Tischendorf
    Medical Department III Gastroenterology, Hepatology and Metabolic Diseases, Aachen University Hospital, RWTH Aachen University, 52074 Aachen, Germany
    Endoscopy 42:203-7. 2010
    ..The aim of the present study was to develop and evaluate a computer-based method for automated classification of colorectal polyps on the basis of vascularization features...
  99. doi Prevalence of nonpolypoid (flat and depressed) colorectal neoplasms in asymptomatic and symptomatic adults
    Roy M Soetikno
    Gastroenterology Section, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    JAMA 299:1027-35. 2008
    ..Prevention has focused on the detection and removal of polypoid neoplasms. Data are limited on the significance of nonpolypoid colorectal neoplasms (NP-CRNs)...
  100. doi Pancolonic chromoendoscopy with indigo carmine versus standard colonoscopy for detection of neoplastic lesions: a randomised two-centre trial
    Jürgen Pohl
    Department of Internal Medicine II, Dr Horst Schmidt Klinik, Wiesbaden, Germany
    Gut 60:485-90. 2011
    b>Colonoscopy is the accepted gold standard for detecting colorectal adenomas, but the miss rate, especially for small and flat lesions, remains unacceptably high...
  101. doi Endoscopic band ligation with a water-jet scope for the treatment of colonic diverticular hemorrhage
    Naoki Ishii
    Department of Gastroenterology, St Luke s International Hospital, Kyoto, Japan
    Dig Endosc 22:232-5. 2010
    ..EBL with a water-jet scope is considered to be a safe and effective endoscopic treatment for colonic diverticular hemorrhage...

Research Grants83

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..shows higher sensitivity than FOBT, and results in better compliance &is more economical than invasive colonoscopy. We studied the expression of 15 mature miRNAs by stem-loop RT primers and TaqMan minor grove binding probes in ..
  3. Real-Time Optical Diagnosis of Inflammatory Bowel Disease using SFDI
    Sylvain Gioux; Fiscal Year: 2013
    ..real-time quantification of tissue optical properties, inclding perfusion, hydration, and metabolism during colonoscopy, thus improving IBD detection...
  4. Interactive Multimedia Intervention to Improve Colonoscopy and Bowel Prep Adhere
    JOHN MATTHEW INADOMI; Fiscal Year: 2012
    ..Regardless of the primary strategy (fecal occult blood testing, sigmoidoscopy, colonoscopy, fecal DNA, computed tomographic colonography [virtual colonoscopy]) colonoscopy is required to evaluate ..
  5. Lipid genotypes, phenotypes, and colorectal adenomas: Elucidating mechanisms
    Polly A Newcomb; Fiscal Year: 2013
    ..We will utilize extant biospecimens and questionnaire data from a completed colonoscopy study among enrollees of Group Health (GH), a large healthcare provider in Washington State...
  6. Faith-Based Approaches to Treating Hypertension and Colon Cancer Prevention
    Hayley S Thompson; Fiscal Year: 2013
    ..have been successfully tested in increasing CRC screening rates, few have focused on improving use of screening colonoscopy among black men in a non- practice community-based setting...
  7. Characterization of the Plasma Proteome in Mouse Models of Colon Cancer
    Kenneth E Hung; Fiscal Year: 2010
    ..Early diagnosis of colorectal cancer by colonoscopy increases the probability of survival...
  8. DEVELOPING VIRTUAL COLONOSCOPY FOR CANCER SCREENING
    JEROME Z LIANG; Fiscal Year: 2013
    ..Computed tomography colonography (CTC) or CT-based virtual colonoscopy (VC) has shown a comparable performance to the gold-standard optical colonoscopy (OC) for detecting polyps of ..
  9. Long-Chain Fatty Acids, Oxidative Stress and Colorectal Neoplasm Risk
    Harvey J Murff; Fiscal Year: 2013
    ..needed for the study have been collected as part of the on-going Tennessee Colorectal Polyp Study, the largest colonoscopy-based adenoma case-control study in the United States...
  10. Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
    Roberd Bostick; Fiscal Year: 2009
    ..of normal-appearing rectal mucosa are being obtained from 1,328 of participants at their 3- or 5-year follow-up colonoscopy. Also, on a subset (n = 112) of these participants, biopsies of normal-appearing rectal mucosa are being taken "..
  11. Development of a Urine Test for the Early Detection of Colon Cancer
    Wei Song; Fiscal Year: 2012
    ..Despite the availability of colonoscopy, the current standard of care for CRC screening, CRC remains the nation's second leading cause of cancer ..
  12. Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention R
    MARGARET FOTI; Fiscal Year: 2012
    ..Examples of this type of prevention include pap test (for cervical cancer), mammography (for breast cancer), colonoscopy (for colorectal cancer) and emerging new imaging techniques to detect breast and lung cancer...
  13. Impact of Family History of Colon Cancer on Adenomas in 40-49 Year Olds
    Philip S Schoenfeld; Fiscal Year: 2012
    ..advanced adenomas defined as adenomas >10 mm, villous adenomas, adenomas with high-grade dysplasia) during colonoscopy. Current guidelines from academic societies and VA Directives provide different recommendations about the need ..
  14. Optimizing Survivorship and Surveillance after Treatment for Colorectal Cancer
    MARVELLA ELIZABETH FORD; Fiscal Year: 2012
    ..e., office visits, carcionoembryonic antigen (CEA) tests, colonoscopy) or adherence to lifestyle-related surveillance guidelines for weight, exercise, alcohol and tobacco use...
  15. Colon Cancer Family Registry Cohort
    NORALANE MOREY LINDOR; Fiscal Year: 2013
    ..selected centers that are able to accomplish this in a cost-effective manner;and (ii) strategically collecting colonoscopy and pathology reports of colonic polyps when possible for high-risk participants (i.e...
  16. Great Lakes/New England Clinical Validation Center
    Dean E Brenner; Fiscal Year: 2013
    ..stool DNA panel, and fecal immunochemical test (FIT) for the early detection of colorectal neoplasia using colonoscopy as the gold standard;2...
  17. Engineered imaging nanoparticles for real-time detection of cancer in the tumor b
    W David Lee; Fiscal Year: 2013
    ..In a pilot study, we will also test our imaging technology to improve the detection of lesions during routine colonoscopy examination...
  18. Selenium Colorectal Cancer Chemoprevention Trials
    PATRICIA ANN THOMPSON; Fiscal Year: 2013
    ..Although most CRAs can be removed at colonoscopy, 20-50% of individuals undergoing repeat colonoscopy 3-5 years later have metachronous, i.e. new, CRAs...
  19. Analyses of Progression to Colon Cancer in a Spectrum of Pathways
    WILLIAM FRANKLIN DOVE; Fiscal Year: 2012
    Observation of human colonic polyps by virtual colonoscopy has indicated several possible fates: regression, stasis, growth, or progression...
  20. Fecal Bacteriotherapy for Relapsing Clostridium difficile Infection
    COLLEEN RENEE KELLY; Fiscal Year: 2013
    ..We propose to conduct a randomized, controlled clinical trial of FMT delivered at colonoscopy for treatment of relapsing CDI with the goal of establishing efficacy and safety data...
  21. Colorectal Neoplasia in SELECT Participants
    M PETER LANCE; Fiscal Year: 2011
    ..histopathology reports of SELECT participants who undergo lower gasatrointestinal endoscopy (sigmoidoscopy or colonoscopy) and removal of colorectal polyps as part of their usual clinical care while in the trial...
  22. INFLAMMATION, OBESITY AND RISK OF COLORECTAL ADENOMAS
    Robert S Sandler; Fiscal Year: 2010
    ..Blood samples will be collected immediately before routine colonoscopy and pinch biopsies of normal rectal mucosa will be collected during colonoscopy...
  23. Modifiers of Intestinal Tumor Progression
    Linda D Siracusa; Fiscal Year: 2012
    ..Although the number of people having colonoscopy screenings is increasing, the incidence of colorectal cancer has not decreased...
  24. Tenth Annual AACR International Conference on Frontiers in Cancer Prevention Rese
    MARGARET FOTI; Fiscal Year: 2011
    ..Examples of this type of prevention include colonoscopy and polypectomy...
  25. MODELING SPATIAL ACCESSIBILITY TO LOWER ENDOSCOPY SERVICES IN THE UNITED STATES
    Min Lian; Fiscal Year: 2013
    ..Lower endoscopic examinations including flexible sigmoidoscopy and colonoscopy have been demonstrated to reduce the risks of incident CRC and CRC-specific mortality through detection and ..
  26. A Cohort Study of Sessile Serrated Polyps and Subsequent Colorectal Neoplasia
    Polly A Newcomb; Fiscal Year: 2013
    ..Men and women, aged 24-74, who received a baseline colonoscopy from 1998-2007 and had a clinical diagnosis of HPs (N=3,900) and a comparison group of colonoscopy patients ..
  27. Colon cancer disparity elimination: a faith-based participatory partnership
    John R Ureda; Fiscal Year: 2012
    ..have an adequate provider base to satisfy the increased demand resulting from this faith oriented barrier-free colonoscopy screening initiative...
  28. Racial Disparity in Colorectal Cancer: Molecular Mechanisms
    ADHIP N MAJUMDAR; Fiscal Year: 2013
    ..specifically the proportion of CD44+CD166- phenotype, was markedly higher in colonic effluent, collected during colonoscopy, of AAs with adenomas than their CA counterparts...
  29. Conjoint analysis to measure physician discrimination toward African Americans
    Sarah Miller; Fiscal Year: 2013
    ..e., colonoscopy, FOBT, FIT)...
  30. In Viro Detection of Neoplasia in the Digestive Tract
    Thomas D Wang; Fiscal Year: 2012
    ..Peptides will be topically applied to the local mucosa via a spray catheter during routine screening colonoscopy to demonstrate the proof of concept of this novel imaging methodology for future applications that provide ..
  31. Training African American Peers as Patient Navigators for Colon Cancer Screening
    Lina Jandorf; Fiscal Year: 2012
    ..due to the preponderance of CRC in AAs beyond the reach of the flexible sigmoidoscopy, increased adherence to colonoscopy among AAs will save lives...
  32. IBDPROMISE: A Web-based Patient-centric Model to Improve Quality and Outcomes
    Ashish Atreja; Fiscal Year: 2013
    ..in which patients with inflammatory bowel disease (IBD) measure their quality of care metrics (such as colonoscopy surveillance) as well as quality of life in waiting rooms and at home;and physicians use this information at ..
  33. Biomarkers of Methionine Metabolism and Risk for Colorectal Adenoma
    Martha J Shrubsole; Fiscal Year: 2010
    ..using plasma samples collected as part of the Tennessee Colorectal Polyp Study (TCPS;P50CA95103), an on-going colonoscopy-based case-control study of colorectal adenoma...
  34. Mitochondria proteome of ulcerative colitis associated dysplasia
    Ru Chen; Fiscal Year: 2013
    ..knowledge for improved, more cost effective surveillance-to differentiate the subset of UC patients who need colonoscopy from those who do not...
  35. Measurement of Inappropriate Screening Tests (MIST)
    Melissa R Partin; Fiscal Year: 2013
    ..that are shorter than recommended by guidelines, screening high-risk patients with a method other than colonoscopy, and screening when the patient is unlikely to benefit because they are under age 50 over age 85 or of have a ..
  36. Pretreatment Assessment of Cognitive and Immune Function in Individuals Newly Dia
    Moira Visovatti; Fiscal Year: 2013
    ..newly diagnosed with CRC and a comparison group of 50 individuals without CRC having a negative screening colonoscopy. Objective measures of attention and memory;serum levels of pro-inflammatory cytokines and selected biomarkers ..
  37. Tailored Touchscreen Colorectal Cancer Prevention in Urban Core Clinics
    K Allen Greiner; Fiscal Year: 2010
    ..depending on stated preference, be offered either an immunochemical fecal occult blood test (iFOBT-lnSure"), colonoscopy, or sigmoidoscopy...
  38. Diet &Activity Community Trial: High-Risk Colon Polyps
    James R Hebert; Fiscal Year: 2012
    ..It also is the one most amenable to primary prevention by screening, with colonoscopy being the most effective screening procedure by far...
  39. Risk Factors for Asymptomatic Diverticulosis
    Robert S Sandler; Fiscal Year: 2013
    ..characteristics of asymptomatic diverticulosis among a group of individuals undergoing first time screening colonoscopy. (2) To determine dietary and lifestyle risk factors for diverticulosis...
  40. Mitochondria as a novel biomarker of colorectal adenoma
    Bharat Thyagarajan; Fiscal Year: 2013
    ..in 392 colorectal adenoma cases and 565 controls collected from three methodologically very similar, colonoscopy-based case-control studies of incident, sporadic colorectal adenomas...
  41. High-resolution optical imaging assessment of microbicide toxicity
    Massoud Motamedi; Fiscal Year: 2011
    ..Unfortunately, current imaging technology such as white light colposcopy or colonoscopy cannot provide high resolution images of epithelial injury and cannot probe below the surface where epithelial ..
  42. Patient Navigation for CRC Screening with Low-Income Minorities
    William H Redd; Fiscal Year: 2011
    ..Recent data indicate that the removal of precancerous polyps (via colonoscopy) decreases CRC incidence by 75-90 percent...
  43. Improving Flexible Sigmoidoscopy in Women by Optical Analysis of Microvasculature
    HEMANT K contact ROY; Fiscal Year: 2010
    ..g. colonoscopy, CT colography) such as being relatively inexpensive, more widely available (performed by primary care ..
  44. Genetic interactions in colorectal cancer susceptibility
    Amanda Ewart Toland; Fiscal Year: 2013
    ..Since cancer mortality for CRC can be significantly reduced by the removal of precursor polyps during screening colonoscopy, identification of at risk individuals will decrease the incidence and mortality of this disease...
  45. Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy
    Wei Chen; Fiscal Year: 2013
    ..inhibitory activity of niclosamide in polyps will be evaluated histochemically after a run-in phase prior to colonoscopy. Given the long-standing efforts and gap in biochemical targets amenable to drug discovery, the finding that a ..
  46. Time lapse to cancer: defining transition from polyp to colorectal cancer (PQ14)
    LISA ALLYN BOARDMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Colonoscopy screening is an effective intervention for identifying and removing precursor lesions for colorectal cancer (CRC). CRC has declined in incidence by 30% in the U.S...
  47. Chemoprevention of Colitis-Associated Neoplasia by 5-ASA
    Margie L Clapper; Fiscal Year: 2012
    ..These data will be complemented by the use of MRI, colonoscopy and whole-body fluorescence imaging with biologically activated probes to monitor both the degree of ..
  48. Veteran and Staff Perceptions of VHA Large Scale Adverse Event Communications
    ANASHUA RANI ELWY; Fiscal Year: 2013
    ..low), and different types of large scale adverse events (dental vs. colonoscopy) which will vary by the notification medium (phone call, letter or both from VHA facilities)...
  49. In Vivo Detection of Flat Colorectal Neoplasms with CT Colonography
    JANNE JOHANNES NAPPI; Fiscal Year: 2010
    ..were thought to be rare outside Japan, where they are reported relatively often on state-of-the-art optical colonoscopy (OC) examinations...
  50. Reducing VA No-Shows: Evaluation of Predictive Overbooking Applied to Colonoscopy
    BRENNAN MASON ROSS SPIEGEL; Fiscal Year: 2013
    ..provided by applicant): Background: The VA has committed extensive resources to ensure that timely screening colonoscopy is readily available for eligible Veterans...
  51. Improving Gastrointestinal Disease Outcomes in Vulnerable Populations
    JOHN MATTHEW INADOMI; Fiscal Year: 2012
    ..development of polyps in which subjects receive counseling about screening using fecal occult blood testing or colonoscopy or their choice of either test...
  52. Nanocytological Fecal Assessment to Personalize Colonoscopic Surveillance
    Hemant K Roy; Fiscal Year: 2013
    ..The medico-legal and clinical consequences of interval CRCs lead to vast overuse of surveillance colonoscopy engendering unnecessary cost, complications etc...
  53. Comparative efficacy of water &indigo carmine vs water or air method
    Joseph W Leung; Fiscal Year: 2013
    ..Asymptomatic veterans referred for sedated colonoscopy for CRC screening at the Sacramento VAMC will be considered for enrollment. Over a 2...
  54. Circulating microRNA as a novel biomarker for inflammatory bowel disease
    ADAM MATTHEW ZAHM; Fiscal Year: 2013
    ..Due to a lack of conclusive biomarkers, the gold standard for diagnosis and evaluation of IBD is endoscopy/colonoscopy, although this invasive and costly procedure is associated with risks to the patient...
  55. Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Re
    MARGARET FOTI; Fiscal Year: 2013
    ..Examples of this type of prevention include colonoscopy and polypectomy...
  56. Computerized Detection of Polyps in CT Colonography
    Hiroyuki Yoshida; Fiscal Year: 2013
    ..Computed tomographic colonography (CTC), or virtual colonoscopy, has become an alternative technique for providing mass screening for colorectal carcinoma due to recent large-..
  57. Communication Patterns in Cancer Screening Navigation with African Americans
    Hayley S Thompson; Fiscal Year: 2010
    ..through collaboration with a funded R01 parent study that is investigating the impact of PN on adherence to colonoscopy referral among AA primary care patients (R01- CA120658)...
  58. Cost-Effectiveness Analysis of Age-and Gender-Based Colorectal Cancer Screening
    Nan Kong; Fiscal Year: 2013
    ..The rationale for the proposed research is that by incorporating screening colonoscopy clinical data into CRC natural history modeling and comparing incremental cost-effectiveness ratios among ..
  59. Neoadjuvant photodynamic immunomodulation for colon cancer
    Edward L Nelson; Fiscal Year: 2011
    ..the central hypothesis that it is safe and feasible to administer intraluminal PDT to colon cancers, via colonoscopy, in the neoadjuvant setting to induce localized tumor cell death and an inflammatory/immune response with an ..
  60. PEER OUTREACH TO FACILITATE COLORECTAL CANCER SCREENING IN SAFETY NET CLINICS
    Aimee S James; Fiscal Year: 2010
    ..The primary outcome of this study is completion of any acceptable CRC screen (FOBT, sigmoidoscopy, colonoscopy) at six-months after baseline, measured by chart review...
  61. Impact of a Novel Patient Educational Booklet on Colonoscopy Quality
    BRENNAN MASON ROSS SPIEGEL; Fiscal Year: 2013
    Impact of a Novel Patient Educational Booklet on Achievement of Quality Indicators in Screening Colonoscopy Project Summary/Abstract Project Background: Colorectal cancer (CRC) is the second leading cause of cancer death in the U.S...
  62. Vitamin D and Colorectal Cancer
    Richard V Benya; Fiscal Year: 2012
    ..In contrast, we use magnification chromo-colonoscopy (MCC) for CRC screening, allowing us to routinely enumerate ACF number in humans...
  63. Preclinical assay development of a novel Colon Cancer Marker (CCSA-4)
    JACK CLEMENS; Fiscal Year: 2007
    ..of colon cancer, including fecal occult blood testing, flexible sigmoidoscopy, double contrast barium enema and colonoscopy. However, costs, risk of complications and discomfort have limited the general use of these methods...
  64. Improving Colonoscopy Quality through Automated Monitoring
    Piet C de Groen; Fiscal Year: 2010
    ..b>Colonoscopy is currently the preferred screening modality for colorectal cancer...
  65. Colon Barrier Breakdown in the Elderly
    James Mullin; Fiscal Year: 2005
    ..Aim 1: We will administer to consenting healthy patients undergoing colonoscopy cancer screening, a solution of either marmitol/lactulose or rbamuose/cellobiose to consume at bedtime...
  66. Managed Care Penetration and Cancer Care
    Nancy Keating; Fiscal Year: 2003
    ..for patients diagnosed with stage II or III rectal cancer; recommended surveillance activities (for example, colonoscopy within one year of diagnosis) for patients diagnosed with colorectal cancer; and PSA testing within one year of ..
  67. Quantifying Risk to Target Screening Colonoscopy
    Thomas Imperiale; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Despite calls for universal colonoscopy (CY) for colorectal cancer (CRC) screening, its clinical application will be limited by issues of cost, safety, constrained resources, and patient acceptance...
  68. Cost-effectiveness of genetic screening for colon cancer
    Sandeep Vijan; Fiscal Year: 2006
    ..screening can improve the efficiency of screening programs by reducing demand for the limited resource of colonoscopy. Methods: Study Design: Simulation modeling...
  69. PROSPECTIVE COMPARISON OF COLONIC IMAGING TEST
    Don Rockey; Fiscal Year: 2001
    ..The most common tests used to image the colon include air contrast barium enema and colonoscopy, each of which is associated with its own sets of benefits and limitations...
  70. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
    ..All surviving cohort members (estimated 1518) will be invited to have a screening colonoscopy. Feasibility data indicate that 1000 will agree to have a colonoscopic exam, among whom we estimate 240 (range ..
  71. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
    ..All surviving cohort members (estimated 1518) will be invited to have a screening colonoscopy. Feasibility data indicate that 1000 will agree to have a colonoscopic exam, among whom we estimate 240 (range ..
  72. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..All surviving cohort members (estimated 1518) will be invited to have a screening colonoscopy. Feasibility data indicate that 1000 will agree to have a colonoscopic exam, among whom we estimate 240 (range ..
  73. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..All surviving cohort members (estimated 1518) will be invited to have a screening colonoscopy. Feasibility data indicate that 1000 will agree to have a colonoscopic exam, among whom we estimate 240 (range ..
  74. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..All surviving cohort members (estimated 1518) will be invited to have a screening colonoscopy. Feasibility data indicate that 1000 will agree to have a colonoscopic exam, among whom we estimate 240 (range ..
  75. Oxidative Stress, DNA Repair & Colorectal Adenoma Risk
    Michael Goodman; Fiscal Year: 2009
    ..biological samples and questionnaire data from a two previously conducted, and methodologically very similar, colonoscopy-based case-control studies of sporadic colorectal adenoma (Parent studies): one conducted in North Carolina and ..
  76. IMPROVING VIRTUAL COLONOSCOPY WITH COMPUTER DETECTION
    Peter Santago; Fiscal Year: 2001
    ..mortality, Congress recently included a provision in the Balanced Budget Act of 1997 to support screening colonoscopy as a means for early detection and removal of colorectal polyps, the precursors to cancer...
  77. EXPERIMENTAL AND CLINICAL STUDIES IN COLORECTAL CANCER
    Thomas McGarrity; Fiscal Year: 1993
    ..In a prospective study, biopsies of normal rectum, sigmoid and ascending colon will be obtained during colonoscopy. Regional differences in mucus glycoproteins (lectin binding), calcium activated proteins and cellular ..
  78. Increasing Colon Cancer Screening in Primary Care
    Ronald Myers; Fiscal Year: 2004
    ..screening regimens that are recommended include having a barium enema X-ray (BE) at five- year intervals or a colonoscopy (CX) every 10 years. Compliance with CRC screening guidelines is low...
  79. Colon Polyp Surveillance with DNA Analysis of Stool
    Philip Schoenfeld; Fiscal Year: 2003
    ..practice guidelines state that individuals with a history of colon adenomas should undergo surveillance colonoscopy to identify and remove newly formed colon adenomas...
  80. RECTAL MUCOSAL PROLIFERATION INDICES--EFFECTS OF CALCIUM
    John Baron; Fiscal Year: 1992
    ..polyp immediately prior to entry, and have been judged free of remaining polyps in the large bowel by colonoscopy. They are randomized to receive either daily calcium carbonate supplementation (1200 mg calcium) or placebo, ..
  81. Critical evaluation of LPCs markers for colorectal cancer
    Yan Xu; Fiscal Year: 2010
    ..While colonoscopy has reported sensitivity and specificity values exceeding 95%, the degree of adherence is low due to the cost, ..
  82. Colonoscopy in Rural Oregon Practice (CROP)
    David Lieberman; Fiscal Year: 2009
    ..Services Task Force recommends that all adults age 50 and older be screened for colorectal cancer with colonoscopy increasingly being utilized as the primary screening method...
  83. Colorectoral cancer screening decisions in primary care
    James Dolan; Fiscal Year: 2006
    ..occult blood tests and flexible sigmoidoscopy every 5 years, double contrast barium enema every 5 years, and colonoscopy every 10 years...