deep brain stimulation

Summary

Summary: Therapy for MOVEMENT DISORDERS, especially PARKINSON DISEASE, that applies electricity via stereotactic implantation of ELECTRODES in specific areas of the BRAIN such as the THALAMUS. The electrodes are attached to a neurostimulator placed subcutaneously.

Top Publications

  1. ncbi Deep brain stimulation for treatment-resistant depression
    Helen S Mayberg
    Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
    Neuron 45:651-60. 2005
  2. ncbi Closed-loop deep brain stimulation is superior in ameliorating parkinsonism
    Boris Rosin
    Department of Medical Neurobiology Physiology, The Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical Association School of Medicine and Hadassah University Hospital, Jerusalem 91120, Israel
    Neuron 72:370-84. 2011
  3. ncbi Subthalamic deep brain stimulation and impulse control in Parkinson's disease
    T D Hälbig
    Federation de Neurologie, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Eur J Neurol 16:493-7. 2009
  4. ncbi Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
    Robert Fisher
    Department of Neurology, Stanford University, Stanford, California 94305 5235, USA
    Epilepsia 51:899-908. 2010
  5. pmc Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression
    Donald A Malone
    Department of Psychiatry and Psychology, Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA
    Biol Psychiatry 65:267-75. 2009
  6. ncbi Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson's disease
    Shen Yang Lim
    Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    J Clin Neurosci 16:1148-52. 2009
  7. ncbi Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease
    Alessandro Stefani
    1IRCCS Fondazione St Lucia, 2Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Brain 130:1596-607. 2007
  8. ncbi Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity
    Andrea A Kuhn
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    Exp Neurol 215:380-7. 2009
  9. ncbi Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues
    Jeff M Bronstein
    University of California, Los Angeles, School of Medicine, Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Arch Neurol 68:165. 2011
  10. pmc Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience
    B D Greenberg
    Department of Psychiatry and Human Behavior, Division of Neurosurgery, Butler Hospital, Alpert Medical School of Brown University, Providence, RI 02906, USA
    Mol Psychiatry 15:64-79. 2010

Detail Information

Publications333 found, 100 shown here

  1. ncbi Deep brain stimulation for treatment-resistant depression
    Helen S Mayberg
    Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
    Neuron 45:651-60. 2005
    ..metabolically overactive in treatment-resistant depression, we studied whether the application of chronic deep brain stimulation to modulate BA25 could reduce this elevated activity and produce clinical benefit in six patients with ..
  2. ncbi Closed-loop deep brain stimulation is superior in ameliorating parkinsonism
    Boris Rosin
    Department of Medical Neurobiology Physiology, The Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical Association School of Medicine and Hadassah University Hospital, Jerusalem 91120, Israel
    Neuron 72:370-84. 2011
    Continuous high-frequency deep brain stimulation (DBS) is a widely used therapy for advanced Parkinson's disease (PD) management. However, the mechanisms underlying DBS effects remain enigmatic and are the subject of an ongoing debate...
  3. ncbi Subthalamic deep brain stimulation and impulse control in Parkinson's disease
    T D Hälbig
    Federation de Neurologie, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Eur J Neurol 16:493-7. 2009
    Experimental studies suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN) induces impulsivity in patients with Parkinson's disease (PD)...
  4. ncbi Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
    Robert Fisher
    Department of Neurology, Stanford University, Stanford, California 94305 5235, USA
    Epilepsia 51:899-908. 2010
    ..We report a multicenter, double-blind, randomized trial of bilateral stimulation of the anterior nuclei of the thalamus for localization-related epilepsy...
  5. pmc Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression
    Donald A Malone
    Department of Psychiatry and Psychology, Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio, USA
    Biol Psychiatry 65:267-75. 2009
    We investigated the use of deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) for treatment refractory depression.
  6. ncbi Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson's disease
    Shen Yang Lim
    Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    J Clin Neurosci 16:1148-52. 2009
    Data regarding the effect of deep brain stimulation (DBS) surgery on the dopamine dysregulation syndrome (DDS), impulse control disorders (ICDs) and punding in Parkinson's disease (PD) are limited...
  7. ncbi Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease
    Alessandro Stefani
    1IRCCS Fondazione St Lucia, 2Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Brain 130:1596-607. 2007
    ..We report the clinical affects of deep brain stimulation (DBS) in the PPN and subthalamic nucleus (STN)...
  8. ncbi Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity
    Andrea A Kuhn
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    Exp Neurol 215:380-7. 2009
    ....
  9. ncbi Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues
    Jeff M Bronstein
    University of California, Los Angeles, School of Medicine, Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Arch Neurol 68:165. 2011
    To provide recommendations to patients, physicians, and other health care providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD).
  10. pmc Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience
    B D Greenberg
    Department of Psychiatry and Human Behavior, Division of Neurosurgery, Butler Hospital, Alpert Medical School of Brown University, Providence, RI 02906, USA
    Mol Psychiatry 15:64-79. 2010
    Psychiatric neurosurgery teams in the United States and Europe have studied deep brain stimulation (DBS) of the ventral anterior limb of the internal capsule and adjacent ventral striatum (VC/VS) for severe and highly treatment-resistant ..
  11. ncbi The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the motor symptoms of Parkinson's disease
    Susan H Fox
    Movement Disorder Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 26:S2-41. 2011
    ..Bilateral subthalamic nucleus deep brain stimulation, bilateral globus pallidus stimulation, and unilateral pallidotomy were updated to efficacious for motor ..
  12. ncbi Ten-year outcome of subthalamic stimulation in Parkinson disease: a blinded evaluation
    Anna Castrioto
    Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
    Arch Neurol 68:1550-6. 2011
    To assess the 10-year motor outcome of deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson disease (PD).
  13. ncbi Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
    Scellig S D Stone
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8
    J Neurosci 31:13469-84. 2011
    b>Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought...
  14. ncbi Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
    Alim Louis Benabid
    Department of Neurosurgery and Neurology, University of Grenoble, CHU Albert Michallon, Grenoble, France
    Lancet Neurol 8:67-81. 2009
    High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN-HFS) is the preferred surgical treatment for advanced Parkinson's disease...
  15. ncbi Probing and regulating dysfunctional circuits using deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Krembil Neuroscience Center, University of Toronto, Toronto, ON M5T 2S8, Canada
    Neuron 77:406-24. 2013
    ..been accompanied by advances in neurosurgical techniques with the increasingly widespread utilization of deep brain stimulation (DBS) to recalibrate dysfunctional circuits...
  16. ncbi Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex
    Qian Li
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Neuron 76:1030-41. 2012
    ..Since STN is the target of deep brain stimulation, it had been assumed that its action is on the nucleus itself...
  17. ncbi Deep brain stimulation of subthalamic nuclei affects arm response inhibition in Parkinson's patients
    G Mirabella
    Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, 86077 Pozzilli IS, Italy
    Cereb Cortex 22:1124-32. 2012
    ..in 10 Parkinson's patients receiving high-frequency electrical stimulation of the STN of both hemispheres (deep brain stimulation, DBS) and in 13 healthy subjects...
  18. ncbi Deep brain stimulation: neuropsychological and neuropsychiatric issues
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, Toronto, Canada
    Mov Disord 21:S305-27. 2006
    ..The efficacy of deep brain stimulation (DBS) for the motor symptoms of advanced PD is well established...
  19. ncbi Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Eur J Neurosci 23:1956-60. 2006
    ..Our results support a link between levodopa-induced improvements in bradykinesia and rigidity and reductions in population synchrony at frequencies < 35 Hz in the region of the STN in patients with PD...
  20. pmc Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
    Michael S Okun
    Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
    Ann Neurol 65:586-95. 2009
    Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
  21. ncbi Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease
    M U Ferraye
    Université de Grenoble, INSERM U836, CHU de Grenoble, Pavillon de Neurologie, BP217, 38043 Grenoble Cedex 9, France
    Brain 133:205-14. 2010
    ....
  22. ncbi Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years
    Sidney H Kennedy
    Department of Psychiatry, Division of Neurosurgery, University Health Network, Toronto, Canada
    Am J Psychiatry 168:502-10. 2011
    ..b>Deep brain stimulation (DBS) is a promising targeted approach involving the bilateral placement of electrodes at specific ..
  23. ncbi Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up
    M C Rodriguez-Oroz
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra and CIMA, Pamplona, Spain
    Brain 128:2240-9. 2005
    b>Deep brain stimulation (DBS) is associated with significant improvement of motor complications in patients with severe Parkinson's disease after some 6-12 months of treatment...
  24. ncbi Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Toronto, Canada
    Biol Psychiatry 64:461-7. 2008
    A preliminary report in six patients suggested that deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) may provide benefit in treatment-resistant depression (TRD)...
  25. ncbi Abnormal oscillatory synchronisation in the motor system leads to impaired movement
    P Brown
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, UK
    Curr Opin Neurobiol 17:656-64. 2007
    ..Here, pathologically synchronised discharges of pyramidal neurons are transmitted to the healthy spinal cord. The result is the synchronous discharge of motor units leading to rhythmic jerking...
  26. ncbi Translational principles of deep brain stimulation
    Morten L Kringelbach
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK
    Nat Rev Neurosci 8:623-35. 2007
    b>Deep brain stimulation (DBS) has shown remarkable therapeutic benefits for patients with otherwise treatment-resistant movement and affective disorders...
  27. ncbi Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial
    Vincent J J Odekerken
    Department of Neurology, Academic Medical Center, Amsterdam, Netherlands
    Lancet Neurol 12:37-44. 2013
    ..We assessed whether globus pallidus pars interna (GPi) deep brain stimulation (DBS) gives greater functional improvement than does subthalamic nucleus (STN) DBS.
  28. ncbi Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
    Nat Neurosci 16:386-7. 2013
    Little is known about the underlying neural mechanism of deep brain stimulation (DBS)...
  29. pmc What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease?
    Simon Little
    Nuffield Departments of Clinical Neurosciences, University of Oxford, United Kingdom
    Ann N Y Acad Sci 1265:9-24. 2012
    Feedback control of deep brain stimulation (DBS) in Parkinson's disease has great potential to improve efficacy, reduce side effects, and decrease the cost of treatment...
  30. ncbi Glutamatergic mechanisms in the dyskinesias induced by pharmacological dopamine replacement and deep brain stimulation for the treatment of Parkinson's disease
    Véronique Sgambato-Faure
    Physiopathology of basal ganglia team, Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique UMR 5229 Université de Lyon I, Bron F 69675 cedex, France
    Prog Neurobiol 96:69-86. 2012
    ..field have been provided by surgical manipulations of the deep basal ganglia nuclei, and particularly by deep brain stimulation (DBS) of the subthalamic nucleus (STN)...
  31. ncbi Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK
    Brain 134:359-74. 2011
    ..The cortical topography and frequencies involved in the alpha and beta networks suggest that these networks may be involved in attentional and executive, particularly motor planning, processes, respectively...
  32. pmc Deep brain stimulation of the subthalamic nucleus alters the cortical profile of response inhibition in the beta frequency band: a scalp EEG study in Parkinson's disease
    Nicole Swann
    Department of Psychology, Neuroscience Graduate Program, Institute for Neural Computation, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 31:5721-9. 2011
    ..We addressed this hypothesis by recording scalp EEG during a stop task while modulating STN activity with deep brain stimulation. We studied 15 human patients with Parkinson's disease and 15 matched healthy control subjects...
  33. ncbi Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation
    Alfonso Fasano
    Istituto di Neurologia, Universita Cattolica del Sacro Cuore, Rome, Italy
    Lancet Neurol 11:429-42. 2012
    b>Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of Parkinson's disease...
  34. ncbi A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
    Adrian W Laxton
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 68:521-34. 2010
    ..We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce ..
  35. ncbi Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization
    A Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, WC1N 3BG UK
    Neuroscience 171:245-57. 2010
    ..We recorded directly from the contacts of the deep brain stimulation (DBS) electrodes as they were introduced in successive 2 mm steps, and assessed phase coherence as a ..
  36. ncbi Deep brain stimulation for essential tremor: a systematic review
    Eliana Della Flora
    Australian Safety and Efficacy Register of New Interventional Procedures Surgical ASERNIP S, Royal Australasian College of Surgeons, Stepney, South Australia, Australia
    Mov Disord 25:1550-9. 2010
    b>Deep brain stimulation (DBS) is a neurosurgical treatment, which has proven useful in treating Parkinson's disease. This systematic review assessed the safety and effectiveness of DBS for another movement disorder, essential tremor...
  37. pmc Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes
    Frances M Weaver
    Center for Management of Complex Chronic Care, Hines VA Hospital, Hines, IL
    Neurology 79:55-65. 2012
    Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.
  38. ncbi Deep brain stimulation: from neurology to psychiatry?
    Paul Krack
    Movement Disorders Unit, Department of Psychiatry and Neurology, University Hospital Grenoble, France
    Trends Neurosci 33:474-84. 2010
    ..neurosurgery has recently been revitalized, starting with treatment of Parkinson's disease, in which deep brain stimulation (DBS) facilitates reversible focal neuromodulation of altered basal ganglia circuits...
  39. ncbi Sing the mind electric - principles of deep brain stimulation
    Morten L Kringelbach
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 32:1070-9. 2010
    The remarkable efficacy of deep brain stimulation (DBS) for a range of treatment-resistant disorders is still not matched by a comparable understanding of the underlying neural mechanisms...
  40. ncbi A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Canada
    J Neurosurg 116:315-22. 2012
    b>Deep brain stimulation (DBS) has been recently investigated as a treatment for major depression. One of the proposed targets for this application is the subcallosal cingulate gyrus (SCG)...
  41. ncbi Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression
    Bettina H Bewernick
    Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
    Biol Psychiatry 67:110-6. 2010
    ..b>Deep brain stimulation (DBS) allows modulation of brain regions that are dysfunctional in depression...
  42. ncbi Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression
    Thomas E Schlaepfer
    Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
    Neuropsychopharmacology 33:368-77. 2008
    b>Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression...
  43. ncbi Unilateral pedunculopontine stimulation improves falls in Parkinson's disease
    Elena Moro
    Division of Neurosurgery, 4 447 Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8 Canada
    Brain 133:215-24. 2010
    ..Our results suggest that pedunculopontine nucleus deep-brain stimulation may be effective in preventing falls in patients with advanced Parkinson's disease but that further evaluation of this procedure is required...
  44. ncbi Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1061-8. 2010
    ..Even when the best available treatments are applied, approximately 10% of patients remain severely afflicted and run a long-term deteriorating course of OCD...
  45. pmc Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial
    Adrian Williams
    Queen Elizabeth Hospital, Birmingham, Birmingham, UK
    Lancet Neurol 9:581-91. 2010
    ..We aimed to assess whether surgery and best medical therapy improved self-reported quality of life more than best medical therapy alone in patients with advanced Parkinson's disease...
  46. ncbi Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
    Karsten Witt
    Christian Albrechts University, Kiel, Germany
    Lancet Neurol 7:605-14. 2008
    b>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor symptoms in patients with Parkinson's disease (PD) and improves their quality of life; however, the effect of DBS on cognitive functions and its psychiatric side-..
  47. ncbi Cortico-cortical coupling in Parkinson's disease and its modulation by therapy
    Paul Silberstein
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 128:1277-91. 2005
    ..This mechanistic similarity may underscore the strong clinical correlation between the therapeutic effects of these treatment modalities...
  48. ncbi Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism
    Puneet Plaha
    Institute of Neurosciences, Department of Neurosurgery, Frenchay Hospital Bristol, UK
    Brain 129:1732-47. 2006
    b>Deep brain stimulation (DBS) has an increasing role in the treatment of idiopathic Parkinson's disease...
  49. ncbi Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease
    A Yugeta
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurology 74:743-8. 2010
    The basal ganglia (BG) play an important role in controlling saccades. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely used as a treatment of Parkinson disease (PD) by altering the function of the BG...
  50. ncbi High frequency stimulation of the subthalamic nucleus impacts adult neurogenesis in a rat model of Parkinson's disease
    Vitaly Khaindrava
    IC2N, IBDML, UMR6216 CNRS Université de la Méditerranée, Marseille, France
    Neurobiol Dis 42:284-91. 2011
    ....
  51. ncbi Auditory midbrain implant: histomorphologic effects of long-term implantation and electric stimulation of a new deep brain stimulation array
    Minoo Lenarz
    Department of Otolaryngology, Hannover Medical University, Hannover, Germany
    Otol Neurotol 28:1045-52. 2007
    ..Chronic implantation and electric stimulation with a human prototype auditory midbrain implant (AMI) array within the inferior colliculus achieves minimal neuronal damage and does not cause any severe complications...
  52. ncbi Cross-species affective functions of the medial forebrain bundle-implications for the treatment of affective pain and depression in humans
    Volker A Coenen
    Stereotaxy and MR based OR techniques Department of Neurosurgery, University Hospital Bonn, Germany
    Neurosci Biobehav Rev 35:1971-81. 2011
    ..Chronic electrical modulation of the reward SEEKING pathways with deep brain stimulation might show anti-depressive effects in humans suffering from MD by re-initiating an emotional equilibrium (..
  53. pmc Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
    A Eusebio
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 82:569-73. 2011
    Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear...
  54. ncbi Standard guidelines for publication of deep brain stimulation studies in Parkinson's disease (Guide4DBS-PD)
    Jerrold L Vitek
    Neuromodulation Research Center, Department Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mov Disord 25:1530-7. 2010
    While the use of deep brain stimulation (DBS) for the treatment of neurological disorders has risen substantially over the last decade, it is often difficult to compare the results from different studies due to the lack of consistent ..
  55. pmc Nucleus accumbens deep brain stimulation produces region-specific alterations in local field potential oscillations and evoked responses in vivo
    Clinton B McCracken
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 29:5354-63. 2009
    b>Deep brain stimulation of the nucleus accumbens (NAC) region is an effective therapeutic avenue for several psychiatric disorders that are not responsive to traditional treatment strategies...
  56. ncbi Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes
    Galit Kleiner-Fisman
    Parkinson s Disease Research Education and Clinical Center, Philadelphia VA Hospital, Philadelphia, Pennsylvania 19104, USA
    Mov Disord 21:S290-304. 2006
    Subthalamic nucleus (STN) deep brain stimulation (DBS) is currently the most common therapeutic surgical procedure for patients with Parkinson's disease (PD) who have failed medical management...
  57. pmc Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus
    Laura B Zahodne
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
    J Neurol 256:1321-9. 2009
    While deep brain stimulation (DBS) surgery is a well-accepted treatment for Parkinson disease (PD) that improves overall quality of life (QoL), its effects across different domains of QoL are unclear...
  58. ncbi Contact dependent reproducible hypomania induced by deep brain stimulation in Parkinson's disease: clinical, anatomical and functional imaging study
    Miguel Ulla
    Service de Neurologie A, Hopital Gabriel Montpied, 58 rue Montalembert, CHU Clermont Ferrand, F 63000 Clermont Ferrand, France
    J Neurol Neurosurg Psychiatry 82:607-14. 2011
    ..on anatomical location of contacts are reported in patients with Parkinson's disease (PD) treated by deep brain stimulation (DBS) of the subthalamic nucleus (STN)...
  59. ncbi Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression
    Paul E Holtzheimer
    Department of Psychiatry, Dartmouth Medical School, One Medical Center Dr, Lebanon, NH 03756, USA
    Arch Gen Psychiatry 69:150-8. 2012
    b>Deep brain stimulation (DBS) may be an effective intervention for treatment-resistant depression (TRD), but available data are limited.
  60. pmc Rules ventral prefrontal cortical axons use to reach their targets: implications for diffusion tensor imaging tractography and deep brain stimulation for psychiatric illness
    Julia F Lehman
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurosci 31:10392-402. 2011
    ..vPFC connections, to examine white matter (WM) integrity, and to target surgical interventions, including deep brain stimulation. We used primate (Macaca nemestrina/Macaca fascicularis) tracing studies and 3D reconstructions of WM ..
  61. pmc Effects of subthalamic nucleus lesions and stimulation upon corticostriatal afferents in the 6-hydroxydopamine-lesioned rat
    Ruth H Walker
    Department of Neurology, James J Peters Veterans Affairs Medical Center, Bronx, New York, United States of America
    PLoS ONE 7:e32919. 2012
    ..STN interventions may achieve at least part of their therapeutic effect in PD by normalizing the location of corticostriatal glutamatergic terminals and by altering striatal glutamatergic neurotransmission...
  62. ncbi Current status of deep brain stimulation for obsessive-compulsive disorder: a clinical review of different targets
    Pelle P de Koning
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Psychiatry Rep 13:274-82. 2011
    ..Currently, deep brain stimulation (DBS) is being investigated as an experimental therapy for treatment-refractory OCD...
  63. ncbi The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation
    Helen Bronte-Stewart
    Department of Neurology and Neurological Sciences, Stanford University, CA 94305 5327, USA
    Exp Neurol 215:20-8. 2009
    ..We recorded LFPs from the subthalamic nucleus (STN) deep brain stimulation (DBS) lead in the operating room in 22 cases from 16 subjects with Parkinson's disease (PD) who were off ..
  64. pmc Dopamine-dependent non-linear correlation between subthalamic rhythms in Parkinson's disease
    S Marceglia
    Dipartimento di Scienze Neurologiche, Universita di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Milano, Italy
    J Physiol 571:579-91. 2006
    ..To this end, we recorded local field potentials (LFPs) from electrodes implanted for deep brain stimulation (DBS) in the subthalamic nucleus (STN) of parkinsonian patients...
  65. pmc Deep brain stimulation activation volumes and their association with neurophysiological mapping and therapeutic outcomes
    C B Maks
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurol Neurosurg Psychiatry 80:659-66. 2009
    Despite the clinical success of deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD), little is known about the electrical spread of the stimulation...
  66. ncbi Deep brain stimulation between 1947 and 1987: the untold story
    Marwan I Hariz
    Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK
    Neurosurg Focus 29:E1. 2010
    b>Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery. Movement disorders are well-established indications for DBS, and a number of other neurological and psychiatric indications are currently being investigated...
  67. ncbi Deep brain stimulation mechanisms: beyond the concept of local functional inhibition
    Jean Michel Deniau
    Institut National de la Santé et de la Recherche Médicale U 667, Dynamique et Physiopathologie des Réseaux Neuronaux, College de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05 France
    Eur J Neurosci 32:1080-91. 2010
    ..Stressing the important functional consequences of axonal activation in deep brain stimulation mechanisms, we highlight the importance of developing anatomical knowledge concerning the fibre ..
  68. pmc A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease
    Valerie Voon
    National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1428, USA
    Brain 131:2720-8. 2008
    Subthalamic nucleus deep brain stimulation improves motor symptoms and quality of life in advanced Parkinson's disease...
  69. pmc Modeling shifts in the rate and pattern of subthalamopallidal network activity during deep brain stimulation
    Philip J Hahn
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue ND20, Cleveland, OH 44195, USA
    J Comput Neurosci 28:425-41. 2010
    b>Deep brain stimulation (DBS) of the subthlamic nucleus (STN) represents an effective treatment for medically refractory Parkinson's disease; however, understanding of its effects on basal ganglia network activity remains limited...
  70. pmc An assessment of current brain targets for deep brain stimulation surgery with susceptibility-weighted imaging at 7 tesla
    Aviva Abosch
    Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Neurosurgery 67:1745-56; discussion 1756. 2010
    b>Deep brain stimulation (DBS) surgery is used for treating movement disorders, including Parkinson disease, essential tremor, and dystonia...
  71. ncbi Deep brain stimulation for movement disorders
    Kelly L Collins
    Department of Neurosurgery, University of Michigan Medical Center, 1500 E Medical Center Drive, SPC 5338, Ann Arbor, MI 48109 5338, USA
    Neurobiol Dis 38:338-45. 2010
    b>Deep brain stimulation (DBS) is a widely employed therapeutic modality for the treatment of movement disorders. Full FDA approval or humanitarian device exemption has been made for Parkinson's disease, tremor, and dystonia...
  72. ncbi Normalizing motor-related brain activity: subthalamic nucleus stimulation in Parkinson disease
    S T Grafton
    Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA
    Neurology 66:1192-9. 2006
    To test whether therapeutic unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson disease (PD) leads to normalization in the pattern of brain activation during movement execution and control ..
  73. pmc Long-term effects of nucleus accumbens deep brain stimulation in treatment-resistant depression: evidence for sustained efficacy
    Bettina H Bewernick
    Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
    Neuropsychopharmacology 37:1975-85. 2012
    b>Deep brain stimulation (DBS) to the nucleus accumbens (NAcc-DBS) was associated with antidepressant, anxiolytic, and procognitive effects in a small sample of patients suffering from treatment-resistant depression (TRD), followed over 1 ..
  74. ncbi Anatomical location of effective deep brain stimulation electrodes in chronic cluster headache
    Denys Fontaine
    Centre Hospitalier Universitaire de Nice Neurosurgery, Nice, France
    Brain 133:1214-23. 2010
    b>Deep brain stimulation of the posterior hypothalamus is a therapeutic approach to the treatment of refractory chronic cluster headache, but the precise anatomical location of the electrode contacts has not been clearly assessed...
  75. pmc Deep brain stimulation: current and future clinical applications
    Mark K Lyons
    Department of Neurological Surgery, Mayo Clinic Hospital, 5777 E Mayo Blvd, Phoenix, AZ 85054, USA
    Mayo Clin Proc 86:662-72. 2011
    b>Deep brain stimulation (DBS) has developed during the past 20 years as a remarkable treatment option for several different disorders...
  76. ncbi Hold your horses: impulsivity, deep brain stimulation, and medication in parkinsonism
    Michael J Frank
    Department of Psychology and Program in Neuroscience, University of Arizona, Tucson, AZ 85721, USA
    Science 318:1309-12. 2007
    b>Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity...
  77. pmc A meta-regression of the long-term effects of deep brain stimulation on balance and gait in PD
    R J St George
    Department of Neurology, Oregon Health and Sciences University, 505 NW 185 Avenue, Beaverton, OR 97006, USA
    Neurology 75:1292-9. 2010
    b>Deep brain stimulation (DBS) alleviates the cardinal Parkinson disease (PD) symptoms of tremor, rigidity, and bradykinesia. However, its effects on postural instability and gait disability (PIGD) are uncertain...
  78. ncbi Long-term evaluation of deep brain stimulation of the thalamus
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurosurg 104:506-12. 2006
    The effects of thalamic deep brain stimulation (DBS) on essential tremor (ET) and Parkinson disease (PD) have been well documented, but there is a paucity of long-term data...
  79. ncbi Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression
    H Johansen-Berg
    Centre for Functional MRI of the Brain, University of Oxford, Oxford OX3 9DU, UK
    Cereb Cortex 18:1374-83. 2008
    Chronic deep brain stimulation (DBS) of subgenual cingulate white matter results in dramatic remission of symptoms in some previously treatment-resistant depression patients...
  80. ncbi Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey
    Ned Jenkinson
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford, UK
    Neuroreport 15:2621-4. 2004
    ..These results suggest that pedunculopontine nuclei stimulation could be clinically effective in treating advanced Parkinson's disease and other akinetic disorders...
  81. ncbi Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational model
    Yixin Guo
    Department of Mathematics, Drexel University, Philadelphia, PA, USA
    J Neurophysiol 99:1477-92. 2008
    The therapeutic effectiveness of deep brain stimulation (DBS) of the subthalamic nucleus (STN) may arise through its effects on inhibitory basal ganglia outputs, including those from the internal segment of the globus pallidus (GPi)...
  82. pmc Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity
    Alan D Dorval
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
    J Neurophysiol 104:911-21. 2010
    b>Deep brain stimulation (DBS) of the basal ganglia can alleviate the motor symptoms of Parkinson's disease although the therapeutic mechanisms are unclear...
  83. ncbi Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder
    Benjamin D Greenberg
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital and Rhode Island Hospital, Providence, RI 02906, USA
    Neuropsychopharmacology 31:2384-93. 2006
    b>Deep brain stimulation (DBS) of the anterior limb of the internal capsule has been shown to be beneficial in the short term for obsessive-compulsive disorder (OCD) patients who exhaust conventional therapies...
  84. ncbi Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation
    Elina Tripoliti
    Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, London, United Kingdom
    Mov Disord 23:2377-83. 2008
    Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response...
  85. pmc Deep brain stimulation does not silence neurons in subthalamic nucleus in Parkinson's patients
    Jonathan D Carlson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon, USA
    J Neurophysiol 103:962-7. 2010
    Two broad hypotheses have been advanced to explain the clinical efficacy of deep brain stimulation (DBS) in the subthalamic nucleus (STN) for treatment of Parkinson's disease...
  86. pmc Optimized beamforming for simultaneous MEG and intracranial local field potential recordings in deep brain stimulation patients
    Vladimir Litvak
    UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    Neuroimage 50:1578-88. 2010
    ..signals and subcortical local field potentials (LFP) in a Parkinson's disease (PD) patient with bilateral deep brain stimulation (DBS) electrodes in the subthalamic nucleus (STN)...
  87. ncbi Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford
    E A Pereira
    Oxford Functional Neurosurgery, Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK
    Br J Neurosurg 22:S41-4. 2008
    b>Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders...
  88. pmc Pallidal burst activity during therapeutic deep brain stimulation
    Philip J Hahn
    Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Exp Neurol 211:243-51. 2008
    Theoretical and experimental analyses of deep brain stimulation (DBS) in the subthalamic nucleus (STN) show both excitatory and inhibitory effects on the neural elements surrounding the electrode...
  89. ncbi Stimulating personality: ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes
    Matthis Synofzik
    Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Biotechnol J 3:1511-20. 2008
    Within the recent development of brain-machine-interfaces deep brain stimulation (DBS) has become one of the most promising approaches for neuromodulation...
  90. ncbi A randomized trial of deep-brain stimulation for Parkinson's disease
    Gunther Deuschl
    Christian Albrechts University, Kiel, Germany
    N Engl J Med 355:896-908. 2006
    ..Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management...
  91. ncbi High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 28:6165-73. 2008
    ..Our findings suggest that HFS may act by modulating pathological patterns of synchronized oscillations, specifically by reduction of pathological beta activity in PD...
  92. ncbi Coupling between beta and high-frequency activity in the human subthalamic nucleus may be a pathophysiological mechanism in Parkinson's disease
    Jon López-Azcárate
    Neuroscience Area, Centro de Investigación Médica Aplicada, Universidad de Navarra, 31008 Pamplona, Spain
    J Neurosci 30:6667-77. 2010
    ..We recorded local field potentials from a group of 15 PD patients (three females) treated with bilateral deep brain stimulation of the subthalamic nucleus, using a high sampling rate (2 kHz) and filters suitable to study high-..
  93. ncbi Intra-operative STN DBS attenuates the prominent beta rhythm in the STN in Parkinson's disease
    Brett Wingeier
    NeuroPace Inc, Mountain View, California, USA
    Exp Neurol 197:244-51. 2006
    Power spectra from local field potentials (LFPs) recorded post-operatively from the deep brain stimulation (DBS) macroelectrode show prominence of the beta rhythm (11-30 Hz) in untreated Parkinson's disease (PD)...
  94. pmc Mechanisms and targets of deep brain stimulation in movement disorders
    Matthew D Johnson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neurotherapeutics 5:294-308. 2008
    Chronic electrical stimulation of the brain, known as deep brain stimulation (DBS), has become a preferred surgical treatment for medication-refractory movement disorders...
  95. ncbi Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation
    N J Ray
    Department of Anatomy, Physiology and Genetics, University of Oxford, Parks Road, OX1 3PT, USA
    Exp Neurol 213:108-13. 2008
    ....
  96. ncbi Addiction in Parkinson's disease: impact of subthalamic nucleus deep brain stimulation
    Tatiana Witjas
    Department of Neurology, University Hospital Timone, Marseille, France
    Mov Disord 20:1052-5. 2005
    ..In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic ..
  97. ncbi Pedunculopontine nucleus stimulation improves gait freezing in Parkinson disease
    Wesley Thevathasan
    Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom
    Neurosurgery 69:1248-53; discussion 1254. 2011
    ..However, controversies remain regarding the clinical application of this new therapy, including patient selection, electrode positioning, and how best to assess outcomes...
  98. ncbi Surgical management of Parkinson's disease
    Thomas Foltynie
    UCL Institute of Neurology, Queen Square, London, UK
    Expert Rev Neurother 10:903-14. 2010
    ..We also provide details of our practice, including patient selection, surgical technique and postoperative stimulation programming and medication adjustment. Current and possible future alternatives to DBS of the STN are also discussed...
  99. pmc Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold
    James F Cavanagh
    Department of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, Rhode Island, USA
    Nat Neurosci 14:1462-7. 2011
    ..b>Deep brain stimulation of the STN in individuals with Parkinson's disease reversed this relationship, resulting in impulsive ..
  100. ncbi The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation
    Hiroki Toda
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    J Neurosurg 108:132-8. 2008
    To examine the influence of deep brain stimulation on hippocampal neurogenesis in an adult rodent model.
  101. pmc Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial
    Frances M Weaver
    Hines VA Hospital, Center for Management of Complex Chronic Care, Hines, Illinois 60141, USA
    JAMA 301:63-73. 2009
    b>Deep brain stimulation is an accepted treatment for advanced Parkinson disease (PD), although there are few randomized trials comparing treatments, and most studies exclude older patients.

Research Grants76

  1. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..Known as deep brain stimulation (DBS), it has been successfully used to treat various human brain disorders (e.g...
  2. Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
    Michael S Okun; Fiscal Year: 2010
    ..Chronic high frequency deep brain stimulation (DBS) has recently emerged as a possible therapeutic option in refractory cases incapacitated by their ..
  3. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..The electrical stimulation of subcortical areas of the brain (deep brain stimulation - DBS) is an effective alternative option, which is rather restricted due to its invasiveness and ..
  4. CYTOLOGICAL STUDIES OF DEVELOPING AND MATURE NEURONS
    Mary Bartlett Bunge; Fiscal Year: 2013
    ..different strategies to make the caudal interface more permissive to axon growth and clinically relevant deep brain stimulation (DBS) and genetic approaches to enhance the intrinsic growth potential of injured brainstem neurons...
  5. CRCNS: Propagation of beta oscillations in cortico-basal ganglia-thalamic loop
    Michelle M McCarthy; Fiscal Year: 2013
    ..The efficacy of new treatments such as deep brain stimulation (DBS) to the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) highlights the ..
  6. The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients
    AMY WILLIS AMARA; Fiscal Year: 2013
    ..Sleep disorders are common, affecting 74-98% of PD patients (1, 5). Deep brain stimulation (DBS) of the sub thalamic nucleus (STN) effectively controls motor symptoms in advanced PD (6-8)...
  7. High School Student NeuroResearch Program (HSNRP)
    Marlys Hearst Witte; Fiscal Year: 2013
    ..blood-brain barrier/neuroprotection, neuroimaging, neuro-genomics/proteomics, neuroengineering, deep brain stimulation, brain cancer, cerebrovascular disease, stroke, and rehabilitation...
  8. The Impact of Deep Brain Stimulation on Frontal-Subcortical Emotional Processing
    Joseph S Neimat; Fiscal Year: 2012
    ..Over the past decade, deep brain stimulation (DBS) has become an increasingly important tool in the treatment of movement disorders...
  9. The mechanistic basis of non-invasive deep brain stimulation by ultrasound
    MERRITT C MADUKE; Fiscal Year: 2012
    ..The results will provide a crucial and quantitative framework for developing focused ultrasound as a non-invasive tool for experimental and therapeutic deep brain stimulation.
  10. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    Nicholas D Schiff; Fiscal Year: 2013
    ..by applicant): The goal of the proposed studies is to develop two complementary animal models to advance deep brain stimulation (DBS) of the central thalamus (CT) as a therapeutic strategy for the treatment of acquired cognitive ..
  11. Cortical and basal ganglia local field potentials in human movement disorders
    Philip A Starr; Fiscal Year: 2012
    ..range (13-30 Hz), and that suppression of beta oscillations is the mechanism for the effectiveness of STN deep brain stimulation (DBS). However, this framework leaves unanswered questions...
  12. Trigeminal Nerve Stimulation for Epilepsy
    Christopher DeGiorgio; Fiscal Year: 2012
    ..Interest is growing in neuromodulation for epilepsy, including vagus nerve stimulation, deep brain stimulation, or closed-loop "responsive" neurostimulation as alternatives to failed drug therapy...
  13. Deep Brain Stimulation in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Deep brain stimulation has revolutionized the treatment of PD and renewed the exploration of surgical therapy for a wide range of neurological disorders including tremor, dystonia, obsessive ..
  14. WincsNanotrode development for DBS
    Kendall H Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) is an effective neurosurgical approach for a variety of neurological and psychiatric disorders including Parkinson's disease, essential tremor, epilepsy, and ..
  15. Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response.
    Fatta B Nahab; Fiscal Year: 2013
    ..g. b-blockers, anticonvulsants, benzodiazepines) and rarely deep brain stimulation of the Vim thalamus...
  16. Design Optimization of Combined Magnetoencephalography and Susceptometry
    Solomon Gilbert Diamond; Fiscal Year: 2013
    ..epilepsy for patients with implanted electrode arrays and in Parkinson disease for patients with implanted deep brain stimulation devices...
  17. Reducing Dyskinesia in Parkinson Disease with Omega-3 Fatty Acids
    KATHRYN ANNE CHUNG; Fiscal Year: 2012
    ..There are surprisingly few treatments for LID, including amantadine and deep brain stimulation. In many instances, amantadine is either poorly tolerated, or provides inadequate benefit, and only a ..
  18. Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
    Itzhak Fried; Fiscal Year: 2013
    ..published findings in the New England Journal of Medicine showing dramatic spatial memory enhancement when deep brain stimulation (DBS) of the human entorhinal area was given during the learning phase [13]...
  19. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
    ..Chronic deep brain stimulation (DBS) in the subthalamic nucleus (STN) and the globus pallidus pars internus (GPi) has proven to be an ..
  20. Aberrant Blink Reflex Motor Learning in a Rat Model of Parkinsons Disease
    JAIME A KAMINER; Fiscal Year: 2013
    ..b>Deep brain stimulation of the subthalamic nucleus (STN DBS) utilizing regular (130 Hz) or irregular (mean frequency 130 Hz) ..
  21. Basal ganglia-thalamic signaling in parkinsonism and deep brain stimulation
    ROBERT STERLING TURNER; Fiscal Year: 2013
    ..Likewise, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may provide relief from parkinsonian signs by suppressing ..
  22. Posterior hypothalamic modulation of pain
    Janean E Holden; Fiscal Year: 2013
    ..b>Deep brain stimulation in the PH is used clinically for severe headaches with success and with few side effects, but has not been ..
  23. Avermectin Receptors for Neuronal Engineering
    Henry A Lester; Fiscal Year: 2010
    ..Ultimately, such procedures, involving both gene therapy and an FDA-approved set of drugs, could also help normalize neurons that are either too active, or not active enough, in psychiatric diseases. ..
  24. Cerebellar stimulation for the treatment of dystonia: preclinical studies
    Ellen J Hess; Fiscal Year: 2013
    ..b>Deep brain stimulation (DBS) of the internal globus pallidus is another treatment option...
  25. CRCNS: Hitting the spot: Optimizing Placement of Deep Brain Stimulation Electrode
    Emad N Eskandar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Intellectual Merit: Deep brain stimulation (DBS) is a highly promising therapy for Parkinson's disease (PD)...
  26. Psychostimulant-Induced Craving and Toxicity
    ROBERT CHRISTOPHER PIERCE; Fiscal Year: 2013
    ..Moreover, comparing and contrasting the effects of optogenetic manipulations to the effects of deep brain stimulation (DBS) will help illuminate the exact mechanism of action of DBS, which remains unclear...
  27. Dentatothalamocortical electrical stimulation in post-stroke motor recovery
    Andre Guelman Machado; Fiscal Year: 2013
    ..Thus far, our results are promising and human translation is feasible given that the technology for deep brain stimulation (DBS) is already FDA approved for the treatment of movement disorders and has been proven safe in over 40,..
  28. PDRemote: Automated Telehealth Diagnostics for Remote Parkinson's Monitoring
    JOSEPH GIUFFRIDA; Fiscal Year: 2013
    ..Treatments include pharmaceutical interventions such as levodopa and surgical procedures such as deep brain stimulation (DBS)...
  29. Neurocognitive Mechanisms of Inhibition Deficits in Parkinson's Disease
    Scott A Wylie; Fiscal Year: 2013
    ..mechanisms and determining the effects of treatments (dopamine medication, subthalamic nucleus deep brain stimulation) for PD on behavioral and neurophysiological measures of inhibition...
  30. Neural Circuit Basis of Behavioral Susceptibility and Resilience to Social Defeat
    JESSICA JILLIAN WALSH; Fiscal Year: 2013
    ..Recent studies have shown Deep Brain Stimulation (DBS) to be robustly efficacious in treating MDD patients and thus research has focused on discovering the ..
  31. Striatal Origin of Pathological Beta Oscillations in Parkinson's Disease
    Xue Han; Fiscal Year: 2013
    ..Newer therapies such as deep brain stimulation (DBS) highlight the fact that PD involves neural network pathology...
  32. Rhythmicity and Synchrony in the Basal Ganglia
    DALTON JAMES SURMEIER; Fiscal Year: 2013
    ..Project 4, directed by Dr. Charles Wilson, explores the mechanisms underlying the symptomatic benefit of deep brain stimulation. Project 5, directed by Dr...
  33. Role of the midline thalamus in arousal, attention and cognition
    ROBERT PAUL VERTES; Fiscal Year: 2013
    ..Schiff and colleagues demonstrated the remarkable findings that deep brain stimulation (DBS) of the midline thalamus in MCS patients restored a range of motor and cognitive functions that had ..
  34. Auditory Thalamic Implant
    STEVEN WAN CHEUNG; Fiscal Year: 2012
    ..Adaptation of established deep brain stimulation and computer assisted surgical navigation technologies to target the auditory thalamus would supplant ..
  35. Apparatus for placing electrodes for deep-brain stimulation
    J Michael Fitzpatrick; Fiscal Year: 2012
    ....
  36. Anatomical and Physiological Characterization of the Thalamostriatal System
    KALYNDA GONZALES; Fiscal Year: 2012
    ..The thalamostriatal system has generated significant interest recently because of clinical data showing that deep brain stimulation (DBS) of the centromedian/parafascicular (CM/PF) complex, the main sources of thalamic inputs to the ..
  37. Deep Brain Stimulation for Alzheimer's Disease
    Constantine G Lyketsos; Fiscal Year: 2013
    ..The urgent need for the development of novel, non-amyloid therapies, the efficacy of deep brain stimulation (DBS) in neuropsychiatric disorders (e.g...
  38. Pilot Clinical Trial of Deep Brain Stimulation for Tinnitus
    Paul Larson; Fiscal Year: 2013
    ..By applying deep brain stimulation (DBS) to area LC of the caudate nucleus, pathological neural activity with perceptual consequences will ..
  39. Clinical and neurophysiological study of subthalamic brain stimulation in PD
    HARRISON CARROLL WALKER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) improves debilitating symptoms of movement disorders when conventional medical therapies, cell transplant strategies, and the delivery of gene-delivered growth factors ..
  40. Temporally precise control of theta oscillations
    Stefan Leutgeb; Fiscal Year: 2013
    ..Because electrical stimulation paradigms can also be effective by inhibiting ongoing neuronal activity, these experiments will provide new insight for the therapeutic use of deep brain stimulation.
  41. Behavioral effects of deep brain stimulation in rats with chronic pain
    THOMAS JEFFREY MARTIN; Fiscal Year: 2013
    ..provided by applicant): The objectives of this proposal are: (1) to examine novel brain regions in which deep brain stimulation (DBS) reverses mechanical allodynia in rats following spinal nerve ligation (SNL), and (2) to determine ..
  42. Mechanism of Action of Deep Brain Stimulation
    Kendall H Lee; Fiscal Year: 2012
    ..chemistry, neuroengineering and neurosurgery will help the applicant elucidate the mechanisms by which Deep Brain Stimulation (DBS) treats Parkinson's disease...
  43. The Role of a Cerebello-Thalamo-Basal Ganglia Pathway in Dystonia
    Rachel Fremont; Fiscal Year: 2013
    ..develop new interventions to test on dystonic ouabain perfused mice including pharmacologic treatments and deep brain stimulation. These experiments together will help define one mechanism of dystonia induction and suggest new methods ..
  44. mPFC, n. accumbens and and reinstatement of cocaine seeking
    ROBERT CHRISTOPHER PIERCE; Fiscal Year: 2012
    ..The novel aspect of this aim is the method of neuronal inactivation. We will utilize deep brain stimulation (DBS), a technique increasingly used clinically for the treatment of neurological diseases that has ..
  45. Structure-Function Relationships in Dystonia: A Network Approach
    David Eidelberg; Fiscal Year: 2013
    ..Finally, in Specific Aim 3, we seek to understand how deep brain stimulation (DBS) works in dystonia when it does work, and identify predictors of patient response...
  46. Top-Down Control of Serotonergic Circuits in Depressive-Like Behaviors
    COLLIN M CHALLIS; Fiscal Year: 2012
    ..Additionally, deep brain stimulation (DBS) of the mPFC in both humans and animals produced an antidepressant-like effect...
  47. Preclinical Assessment of Deep Brain Stimulation for the Treatment of Alcoholism
    ZACHARY AARON RODD; Fiscal Year: 2013
    ..Recent human studies have indicated that a neurosurgical procedure, deep brain stimulation (DBS), is effective at reducing alcohol consumption in alcoholics with a co-morbid psychological treatment ..
  48. Deep Brain Stimulation Array for Neuromodulation
    Rio J Vetter; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep Brain Stimulation (DBS) devices - 'brain pacemakers'- have emerged as a revolutionary new approach to the treatment of neurological disorders...
  49. Synchronous Activity in Hybrid Neuronal Microcircuits
    John A White; Fiscal Year: 2013
    ..Second, electronic technology being developed and used for this project will be valuable for feedback-based electrical stimulation of brain structures in neurological patients. ..
  50. Neuronal Oscillations and Dysregulated Motor Learning in Parkinsonian Rats
    Daniel K Leventhal; Fiscal Year: 2013
    ..This is an important issue because therapeutic deep brain stimulation (DBS) is believed to work by disrupting "pathologic" beta oscillations...
  51. Evaluation of Carbon Nanotube Electrodes for Neural Stimulation
    CHARLES BERNARD PARKER; Fiscal Year: 2012
    ..is to evaluate carbon nanotubes (CNTs) as lower impedance, smaller electrodes for neurostimulation, using deep brain stimulation (DBS) as a test case...
  52. EXERCISE AND PARKINSON'S: COMPARING INTERVENTIONS AND EXPLORING NEURAL MECHANISMS
    Gammon M Earhart; Fiscal Year: 2013
    ..has the potential to alter our approach to the treatment of gait difficulties in PD, as it my assist in the development of new or improved exercise interventions and/or identification of new surgical targets for deep brain stimulation.
  53. DBS-Expert: Automated Deep Brain Stimulation Programming Using Functional Mapping
    DUSTIN ALLEN HELDMAN; Fiscal Year: 2012
    ..build, and clinically assess DBS-Expert, an expert system for optimizing the postoperative programming of deep brain stimulation (DBS) systems in patients with movement disorders such as Parkinson's disease (PD)...
  54. STN Stimulation: Neural Control of Movement and Posture
    DANIEL MONTIE CORCOS; Fiscal Year: 2011
    High frequency deep brain stimulation of the subthalamic nucleus (STN DBS) dramatically ameliorates most but not all symptoms of Parkinson[unreadable]s disease (PD)...
  55. Ethics of Control and Consent in Brain Stimulation for Parkinson Disease
    CYNTHIA M S KUBU; Fiscal Year: 2010
    ..study examines the ethical challenges inherent in participants'considerations of control using Deep Brain Stimulation (DBS) for the treatment of Parkinson disease (PD) as a paradigm...
  56. ParkinStep: Automated PD Gait and Balance Assessment for Optimizing DBS
    Joseph P Giuffrida; Fiscal Year: 2010
    ..A standardized platform for repeatable, automated testing to assess gait and balance in response to deep brain stimulation (DBS) settings should optimize patient outcomes and provide a novel research tool for new DBS protocols ..
  57. Deducing the origin and effect of extracellular electric fields in hippocampus
    Christof Koch; Fiscal Year: 2013
    ..in epilepsy, and the short- and long-range eect of direct brain stimulation via electrical current, as in deep brain stimulation. Here, therapy ecacy crucially depends on a solid understanding of the eect of extracellular elds on ..
  58. Development and Evaluation of Biodegradable Neural Probes
    Martin Han; Fiscal Year: 2009
    ..The devices described in this application will also advance knowledge in basic and applied neuroscience. ..
  59. The mechanism by which electric stimulation activates retinal neurons
    SHELLEY FRIED; Fiscal Year: 2013
    ..For example, deep brain stimulation (DBS) is now routinely used to treat Parkinsonian tremors and cochlear prosthetics stimulate the auditory ..
  60. Temporal Patterns of Deep Brain Stimulation
    Warren M Grill; Fiscal Year: 2013
    Chronic high frequency electrical stimulation of the brain, called deep brain stimulation (DBS), has evolved from a highly experimental technique to a well-established therapy for the treatment of movement disorders including dystonia, ..
  61. Habenulomesencephalic pathway in aversion, reward and depression
    Paul D Shepard; Fiscal Year: 2013
    ..For these patients, traditional pharmacological treat- ments are often not effective, and deep brain stimulation of discrete brain regions has emerged as one of the only viable treatment options...
  62. Mechanisms of Movement Facilitation and Release by Cueing in Parkinson's disease
    Colum D MacKinnon; Fiscal Year: 2013
    ..akinesia, start hesitation and FOG often becomes refractory to current treatments such as levodopa and deep brain stimulation. Currently there are no effective treatments for these symptoms...
  63. Influence of the Basal Ganglia on Cerebellar Action
    Alan Gibson; Fiscal Year: 2007
    ..b>Deep brain stimulation at specific sites in the basal ganglia can provide effective relief of Parkinson symptoms...
  64. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Chronic Deep Brain Stimulation (DBS) emerged in the last decade as a revolutionary new approach to the treatment of neurological and psychiatric disorders...
  65. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2002
    This proposal is submitted in response to RFA NS-99-006; "Consortium on deep brain stimulation for the treatment of Parkinson's Disease...
  66. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
  67. CORTICAL ACTIVITY, COGNITIVE AND MOTOR FUNCTION, AND DBS
    WENDY LOMBARDI; Fiscal Year: 2003
    ..through the study of cortical activation on functional MRI (fMRI), that the cognitive and motor effects of deep brain stimulation (DBS) in the basal ganglia are mediated through the selective activation of discrete regions of the ..
  68. Advanced Technology and Tools for DBS Programming for Speech Functionality
    Craig van Horne; Fiscal Year: 2009
    ..Parkinson's disease (PD) is one of the main disorders disrupting speech. Recently, deep brain stimulation (DBS) has proven to be effective for motor problems in patients with PD and other movement disorders...
  69. Basal Ganglia Neurophysiology during DBS in Rats
    Jing Yu Chang; Fiscal Year: 2006
    ..Renewed use of the deep brain stimulation (DBS) method provides a new opportunity for treating PD...
  70. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
    ..In many patients, these "axial symptoms" are resistant to levodopa therapy. A potential advantage of deep brain stimulation (DBS) of globus pallidus internal (GPi) and the subthalamic nucleus (STN) could be improvement of these ..
  71. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2005
    DESCRIPTION (Adapted From The Applicant's Abstract): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to be an effective treatment for the motor symptoms of Parkinson's disease (PD), particularly improving ..
  72. Two-photon calcium imaging of the effects of cortical microstimulation
    R Reid; Fiscal Year: 2009
    ..Worldwide, more than 60,000 deaf patients have recovered hearing through cochlear implants. Similarly, deep brain stimulation has proven highly valuable in the treatment of intractable movement disorders including Parkinson's...
  73. Neural Mechanisms of Reinforcement Learning in the Basal Ganglia
    Kareem Zaghloul; Fiscal Year: 2009
    ..The goal of this proposal is to use data obtained from microelectrode recordings during deep brain stimulation surgery (DBS) for the treatment of Parkinson's disease (PD) and obsessive compulsive disorder (OCD) ..
  74. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Although high-frequency deep brain stimulation (HF-DBS) in the globus pallidus or subthalamic nucleus has become a common technique used to treat drug-resistant symptoms of Parkinson's disease, ..
  75. ELECTROMECHANICAL NONINVASIVE NEURAL STIMULATION: SAFETY AND EFFICACY
    Timothy Wagner; Fiscal Year: 2009
    ..from fundamental limitations and have yet to reach the level of efficacy of invasive methods, such as deep brain stimulation. Electromechanical Stimulation (EMS) is an improved noninvasive modality, which offers the potential of ..
  76. Targeted Motor Neuron Gene Delivery for Spasticity
    Nicholas Boulis; Fiscal Year: 2006
    ..The dual emergence of accurate stereotaxis and deep brain stimulation (DBS) have generated a revolution in the application of targeted neuromodulation applied to movement ..