debridement

Summary

Summary: The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)

Top Publications

  1. pmc Aggressive early débridement for treatment of acutely infected cemented total hip arthroplasty
    Mohamed Sukeik
    Department of Trauma and Orthopaedics, University College London Hospital, 235 Euston Road, NW1 2BU London, United Kingdom
    Clin Orthop Relat Res 470:3164-70. 2012
  2. ncbi Fournier's gangrene: an analysis of repeated surgical debridement
    Sam N Chawla
    Department of Urology, Temple University Medical Center, Philadelphia, PA 19140, USA
    Eur Urol 43:572-5. 2003
  3. doi Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy
    Sally Hayes
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cathays, Cardiff, Wales, United Kingdom
    J Cataract Refract Surg 34:657-61. 2008
  4. doi One-stage posterior debridement, transforaminal lumbar interbody fusion and instrumentation in treatment of lumbar spinal tuberculosis: a retrospective case series
    Hong Qi Zhang
    Department of Spine Surgery, Xiangya Hospital of Central South University, Xiangya Road 87, Changsha, China
    Arch Orthop Trauma Surg 133:333-41. 2013
  5. pmc One-stage surgical treatment for upper thoracic spinal tuberculosis by internal fixation, debridement, and combined interbody and posterior fusion via posterior-only approach
    Hongqi Zhang
    Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China
    Eur Spine J 22:616-23. 2013
  6. pmc A posterior versus anterior surgical approach in combination with debridement, interbody autografting and instrumentation for thoracic and lumbar tuberculosis
    Xiaobing Pu
    Orthopaedics Department, Southwest Hospital, Third Military Medical University, Chongqing, China
    Int Orthop 36:307-13. 2012
  7. pmc Prosthetic joint-associated infections treated with DAIR (debridement, antibiotics, irrigation, and retention): analysis of risk factors and local antibiotic carriers in 91 patients
    Jesse W P Kuiper
    Department of Orthopedic Surgery, Medical Center Alkmaar, Alkmaar, The Netherlands
    Acta Orthop 84:380-6. 2013
  8. doi Arthroscopic debridement versus refixation of the acetabular labrum associated with femoroacetabular impingement
    Christopher M Larson
    Minnesota Sports Medicine, Eden Prairie, Minnesota 55344, USA
    Arthroscopy 25:369-76. 2009
  9. doi Efficacy of corneal collagen cross-linking using a custom epithelial debridement technique in thin corneas: a confocal microscopy study
    Vedat Kaya
    Beyoglu Eye Training and Research Hospital, Istanbul, Turkey
    J Refract Surg 27:444-50. 2011
  10. doi Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement
    Gregor Wollensak
    Department of Ophthalmology, Eye Laser Institute, Martin Luther University, Halle, Germany
    J Cataract Refract Surg 35:540-6. 2009

Detail Information

Publications367 found, 100 shown here

  1. pmc Aggressive early débridement for treatment of acutely infected cemented total hip arthroplasty
    Mohamed Sukeik
    Department of Trauma and Orthopaedics, University College London Hospital, 235 Euston Road, NW1 2BU London, United Kingdom
    Clin Orthop Relat Res 470:3164-70. 2012
    ..Irrigation and débridement with or without exchange of modular components remains an attractive alternative to two-stage reimplantation in acutely infected THAs but with variable results from previous studies...
  2. ncbi Fournier's gangrene: an analysis of repeated surgical debridement
    Sam N Chawla
    Department of Urology, Temple University Medical Center, Philadelphia, PA 19140, USA
    Eur Urol 43:572-5. 2003
    We wanted to determine if there was a difference in outcome for those patients with Fournier's disease who underwent numerous debridements as opposed to only one initial debridement.
  3. doi Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy
    Sally Hayes
    School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cathays, Cardiff, Wales, United Kingdom
    J Cataract Refract Surg 34:657-61. 2008
    ..To evaluate the importance of complete epithelial removal before riboflavin-ultraviolet-A (UVA) corneal collagen crosslinking therapy...
  4. doi One-stage posterior debridement, transforaminal lumbar interbody fusion and instrumentation in treatment of lumbar spinal tuberculosis: a retrospective case series
    Hong Qi Zhang
    Department of Spine Surgery, Xiangya Hospital of Central South University, Xiangya Road 87, Changsha, China
    Arch Orthop Trauma Surg 133:333-41. 2013
    The purpose of this study is to compare the clinical outcomes of surgical management by one-stage posterior debridement, transforaminal lumbar interbody fusion (TLIF) and instrumentation and combined posterior and anterior approaches for ..
  5. pmc One-stage surgical treatment for upper thoracic spinal tuberculosis by internal fixation, debridement, and combined interbody and posterior fusion via posterior-only approach
    Hongqi Zhang
    Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China
    Eur Spine J 22:616-23. 2013
    To investigate the clinical efficacy and feasibility of one-stage surgical treatment for upper thoracic spinal tuberculosis by internal fixation, debridement, and combined interbody and posterior fusion via a posterior-only approach.
  6. pmc A posterior versus anterior surgical approach in combination with debridement, interbody autografting and instrumentation for thoracic and lumbar tuberculosis
    Xiaobing Pu
    Orthopaedics Department, Southwest Hospital, Third Military Medical University, Chongqing, China
    Int Orthop 36:307-13. 2012
    The purpose of this study was to compare posterior and anterior surgical approach in combination with debridement, interbody autografting and instrumentation for thoracic and lumbar tuberculosis...
  7. pmc Prosthetic joint-associated infections treated with DAIR (debridement, antibiotics, irrigation, and retention): analysis of risk factors and local antibiotic carriers in 91 patients
    Jesse W P Kuiper
    Department of Orthopedic Surgery, Medical Center Alkmaar, Alkmaar, The Netherlands
    Acta Orthop 84:380-6. 2013
    For prosthetic joint-associated infection (PJI), a regimen of debridement, antibiotics, irrigation, and retention of the prosthesis (DAIR) is generally accepted for acute infections...
  8. doi Arthroscopic debridement versus refixation of the acetabular labrum associated with femoroacetabular impingement
    Christopher M Larson
    Minnesota Sports Medicine, Eden Prairie, Minnesota 55344, USA
    Arthroscopy 25:369-76. 2009
    The purpose of this study was to compare the outcomes of arthroscopic labral debridement with those of labral refixation.
  9. doi Efficacy of corneal collagen cross-linking using a custom epithelial debridement technique in thin corneas: a confocal microscopy study
    Vedat Kaya
    Beyoglu Eye Training and Research Hospital, Istanbul, Turkey
    J Refract Surg 27:444-50. 2011
    To examine the corneal collagen cross-linking (CXL) effect with a customized epithelial debridement technique in thin corneas using anterior segment optical coherence tomography (OCT) and confocal microscopy.
  10. doi Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement
    Gregor Wollensak
    Department of Ophthalmology, Eye Laser Institute, Martin Luther University, Halle, Germany
    J Cataract Refract Surg 35:540-6. 2009
    To test the biomechanical efficiency of corneal crosslinking with riboflavin without epithelial debridement (C3-R).
  11. pmc Infection control rate of irrigation and débridement for periprosthetic joint infection
    Loukas Koyonos
    The Rothman Institute of Orthopaedics, Thomas Jefferson University Hospital, 925 Chestnut Street, 5th Floor, Philadelphia, PA 19107, USA
    Clin Orthop Relat Res 469:3043-8. 2011
    ..Irrigation and débridement with retention of prosthesis is commonly performed for periprosthetic joint infection. Infection control is reportedly dependent on timing of irrigation and débridement relative to the index procedure...
  12. pmc Early prosthetic joint infections treated with debridement and implant retention: 38 primary hip arthroplasties prospectively recorded and followed for median 4 years
    Marianne Westberg
    Department of Orthopaedics, Oslo University Hospital, Oslo, Norway
    Acta Orthop 83:227-32. 2012
    b>Debridement and retention of the prosthesis is often attempted to treat early prosthetic joint infection (PJI)...
  13. pmc Can implant retention be recommended for treatment of infected TKA?
    Ho Rim Choi
    Harris Orthopedic Laboratory, Department of Orthopedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1126, Boston, MA 02114, USA
    Clin Orthop Relat Res 469:961-9. 2011
    ..Retention treatment is reportedly associated with lower infection control rates than two-stage revision. However, the studies on which this presumption are based depend on comparisons of historical rather than concurrent controls...
  14. pmc Polymicrobial prosthetic joint infections: risk factors and outcome
    Camelia E Marculescu
    Division of Infectious Diseases, Medical University of South Carolina, 100 Doughty Street, Suite 210, BA IOP South, PO Box 250752, Charleston, SC 29425, USA
    Clin Orthop Relat Res 466:1397-404. 2008
    ..We found the following factors associated with polymicrobial prosthetic joint infections: the presence of a soft tissue defect/wound dehiscence (odds ratio, 5.9), drainage (odds ratio, 5.0), and age 65 years or older (odds ratio, 2.8)...
  15. ncbi Comparison of injectable calcium phosphate bone cement grafting and open flap debridement in periodontal intrabony defects: a randomized clinical trial
    Yoshinori Shirakata
    Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Periodontol 79:25-32. 2008
    ..This study aimed to evaluate the clinical efficacy of a new, injectable calcium phosphate bone cement (CPC) in human periodontal intrabony defects...
  16. doi Spontaneous rupture of the oesophagus: Boerhaave's syndrome in 2008. Literature review and treatment algorithm
    J P de Schipper
    Department of Surgery, St Elisabeth Hospital, Hilvarenbeekseweg 60, Tilburg, The Netherlands
    Dig Surg 26:1-6. 2009
    ..Therefore, we reviewed all published literature in order to design a treatment algorithm based on the literature...
  17. ncbi Clinical effectiveness and cost-effectiveness of 2 management strategies for infected total hip arthroplasty in the elderly
    D N Fisman
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, MA, USA
    Clin Infect Dis 32:419-30. 2001
    ..Exchange arthroplasty is usually advocated but has high rates of surgical morbidity and is expensive. Debridement with prosthesis retention is associated with less morbidity, but high rates of relapsed infection have been ..
  18. ncbi Outcome of penicillin-susceptible streptococcal prosthetic joint infection treated with debridement and retention of the prosthesis
    A M Meehan
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Clin Infect Dis 36:845-9. 2003
    b>Debridement with retention of the prosthesis was the initial treatment modality for 19 cases of penicillin-susceptible streptococcal prosthetic joint infection that occurred in 18 patients who presented to the Mayo Clinic (Rochester, ..
  19. pmc One hundred and twelve infected arthroplasties treated with 'DAIR' (debridement, antibiotics and implant retention): antibiotic duration and outcome
    I Byren
    Nuffield Orthopaedic Centre, Oxford, UK
    J Antimicrob Chemother 63:1264-71. 2009
    We describe treatment failure rates by antibiotic duration for prosthetic joint infection (PJI) managed with debridement, antibiotics and implant retention (DAIR).
  20. ncbi Wound bed preparation: a systematic approach to wound management
    Gregory S Schultz
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida, USA
    Wound Repair Regen 11:S1-28. 2003
    ....
  21. ncbi Lower extremity trauma: trends in the management of soft-tissue reconstruction of open tibia-fibula fractures
    Brian M Parrett
    Division of Plastic and Reconstructive Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02478, USA
    Plast Reconstr Surg 117:1315-22; discussion 1323-4. 2006
    ..This review documents the changing treatment protocol in the authors' institution for these injuries...
  22. doi Irrigation and debridement in the management of prosthetic joint infection: traditional indications revisited
    Khalid A Azzam
    Rothman Institute of Orthopedics at Thomas Jefferson University, Department of Orthopedic Surgery, Thomas Jefferson University Hospital Rothman Institute, Philadelphia, Pennsylvania 19107, USA
    J Arthroplasty 25:1022-7. 2010
    Irrigation and debridement (I and D) is a procedure commonly used for the treatment of acute periprosthetic infection...
  23. ncbi Outcome of prosthetic joint infections treated with debridement and retention of components
    C E Marculescu
    Division of Infectious Diseases, Medical University of South Carolina, Charleston, USA
    Clin Infect Dis 42:471-8. 2006
    b>Debridement and retention of the prosthesis represents an attractive surgical modality for treatment of prosthetic joint infection, but risk factors for treatment failure require clarification.
  24. ncbi Guiding empirical antibiotic therapy in orthopaedics: The microbiology of prosthetic joint infection managed by debridement, irrigation and prosthesis retention
    E Moran
    Department of Microbiology and Infectious Disease, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    J Infect 55:1-7. 2007
    This study describes the microbiological spectrum of prosthetic joint infection (PJI) managed by debridement, washout and retention and so guides the choice of empirical antibiotics within this patient group.
  25. ncbi Management of infection associated with total hip arthroplasty according to a treatment algorithm
    S G Giulieri
    Medical University Clinic, Kantonsspital, CH 4410 Liestal, Switzerland
    Infection 32:222-8. 2004
    ..An algorithm for the management of hip arthroplasty-associated infections was validated in a cohort study...
  26. ncbi Pyogenic vertebral osteomyelitis
    E J Carragee
    Stanford University Medical Center, California 94305, USA
    J Bone Joint Surg Am 79:874-80. 1997
    ..Forty-two patients were managed with debridement and arthrodesis...
  27. ncbi The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets
    Carl L Nelson
    Department of Orthopaedic Surgery, University of Arkansas Medical Sciences, Little Rock 72205, USA
    J Orthop Res 20:643-7. 2002
    ..10% tobramycin sulfate, placebo calcium sulfate pellets and IM tobramycin, placebo calcium sulfate pellets, or debridement. Serum and wound exudate tobramycin concentrations and serum calcium levels were measured...
  28. doi Wound debridement potential of glycosidases of the wound-healing maggot, Lucilia sericata
    G Telford
    Immune Modulation Research Group, School of Pharmacy, University of Nottingham, Nottingham, UK
    Med Vet Entomol 26:291-9. 2012
    ..These data suggest that maggot glycosidases remove sugars from slough/eschar proteins. This may contribute to debridement, which is ultimately accomplished by a suite of biochemically distinct enzymes present in ES1.
  29. doi Arthroscopic debridement versus refixation of the acetabular labrum associated with femoroacetabular impingement: mean 3.5-year follow-up
    Christopher M Larson
    Minnesota Orthopedic Sports Medicine Institute, Edina, MN 55435, USA
    Am J Sports Med 40:1015-21. 2012
    The acetabular labrum provides a sealing function and a degree of hip joint stability. Limited, short-term follow-up studies suggest that labral refixation/preservation leads to superior outcomes compared with labral debridement/excision.
  30. doi Six weeks of antibiotic treatment is sufficient following surgery for septic arthroplasty
    Louis Bernard
    Orthopaedic Surgery Service, Geneva University Hospitals and Medical School, Geneva, Switzerland
    J Infect 61:125-32. 2010
    ..In the treatment of prosthetic joint infections (PJI), the benefit of antibiotic therapy for more than 6 weeks after surgery is uncertain. We compared PJI cure rates according to the duration of antibiotics, 6 versus 12 weeks...
  31. ncbi Guidelines for the treatment of pressure ulcers
    JoAnne Whitney
    University of Washington, Seattle, WA, USA
    Wound Repair Regen 14:663-79. 2006
  32. doi Peroral transgastric/transduodenal necrosectomy: success in the treatment of infected pancreatic necrosis
    Jean Escourrou
    Department of Gastroenterology, Rangueil University Hospital, Paul Sabatier University, Toulouse, France
    Ann Surg 248:1074-80. 2008
    ..To assess the results and complications of an endoscopic transgastric/transduodenal approach as a possible alternative to conventional surgery...
  33. doi Effect of epithelial retention and removal on riboflavin absorption in porcine corneas
    Konstantinos Samaras
    Department of Ophthalmology, St Thomas Hospital, London, United Kingdom
    J Refract Surg 25:771-5. 2009
    ....
  34. doi Gram-negative prosthetic joint infection treated with debridement, prosthesis retention and antibiotic regimens including a fluoroquinolone
    C A Aboltins
    Department of Infectious Diseases, Melbourne and Victoria Pde, Fitzroy, Victoria, Australia
    Clin Microbiol Infect 17:862-7. 2011
    ..treatment outcomes of Gram-negative prosthetic joint infections treated with prosthesis retention and surgical debridement, especially where biofilm-active antibiotics such as fluoroquinolones are used...
  35. doi Early prosthetic joint infection: outcomes with debridement and implant retention followed by antibiotic therapy
    J Cobo
    Hospital Ramon y Cajal, IRYCIS, Madrid, Spain
    Clin Microbiol Infect 17:1632-7. 2011
    Recent expert reviews recommend a conservative surgical strategy - debridement and irrigation, antibiotics and implant retention (DAIR) - for most early post-surgical prosthetic joint infections (PJI)...
  36. ncbi Surgical site infection - a European perspective of incidence and economic burden
    David J Leaper
    University Hospital of North Tees, Stockton on Tees, UK
    Int Wound J 1:247-73. 2004
    ..A significant improvement in study design, data collection, analysis and reporting will be necessary to ensure that SSI baseline rates are more accurately assessed to enable the evaluation of future cost-effective measures...
  37. ncbi Necrotizing fasciitis: current concepts and review of the literature
    Babak Sarani
    Division of Traumatology and Surgical Critical Care, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA
    J Am Coll Surg 208:279-88. 2009
  38. pmc Intraoperative molds to create an articulating spacer for the infected knee arthroplasty
    Geoffrey S Van Thiel
    Rush University Medical Center, 1611 West Harrison Street, Suite 300, Chicago, IL 60612, USA
    Clin Orthop Relat Res 469:994-1001. 2011
    ....
  39. doi Evidence-based recommendations for the use of Negative Pressure Wound Therapy in traumatic wounds and reconstructive surgery: steps towards an international consensus
    E Krug
    Leiden University Medical Centre, The Netherlands
    Injury 42:S1-12. 2011
    ..The development of evidence-based recommendations for NPWT with direct validation from a large group of practicing clinicians offers a broader basis for consensus than work by an expert panel alone...
  40. doi Accelerated treatment of postpneumonectomy empyema: a binational long-term study
    Didier Schneiter
    Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland
    J Thorac Cardiovasc Surg 136:179-85. 2008
    ..Postpneumonectomy empyema remains a clinical challenge. We proposed an accelerated therapy without an open chest window 5 years ago. This concept was evaluated on a larger scale in 2 centers in 2 different countries...
  41. ncbi Effect of repeated irrigation and debridement on fracture healing in an animal model
    Sang Hyun Park
    The J Vernon Luck Sr M D Orthopaedic Research Center at Orthopaedic Hospital UCLA, 2400 S Flower Street, Los Angeles, CA 90007, USA
    J Orthop Res 20:1197-204. 2002
    The initial management of open fractures often requires repeated irrigation and debridement of the open wound and stabilization of the fracture...
  42. ncbi Surgical treatment of periodontal intrabony defects with calcium sulfate implant and barrier versus collagen barrier or open flap debridement alone: a 12-month randomized controlled clinical trial
    Michele Paolantonio
    Department of Periodontology, University G D Annunzio School of Dentistry, Chieti, Italy
    J Periodontol 79:1886-93. 2008
    ..tissue regeneration with calcium sulfate graft and membrane (CS) versus guided tissue regeneration with collagen membrane (CM) or open flap debridement (OFD) only in terms of clinical attachment gain in periodontal intrabony defects.
  43. pmc The relationship between time to surgical debridement and incidence of infection after open high-energy lower extremity trauma
    Andrew N Pollak
    University of Maryland School of Medicine, 22 South Greene Street, Suite T3R54, Baltimore, MD 21201, USA
    J Bone Joint Surg Am 92:7-15. 2010
    ..The purpose of the present study was to evaluate the relationship between the timing of the initial treatment of open fractures and the development of subsequent infection as well as to assess contributing factors...
  44. pmc Peroral endoscopic drainage/debridement of walled-off pancreatic necrosis
    Georgios I Papachristou
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Ann Surg 245:943-51. 2007
    Experience with minimal access, transoral/transmural endoscopic drainage/debridement of walled-off pancreatic necrosis (WOPN) after necrotizing pancreatitis is limited. We sought to determine outcome using this technique.
  45. ncbi Primary osteoarthritis of the elbow: lack of radiographic evidence for morphologic predisposition, results of operative debridement at intermediate follow-up, and basis for a new radiographic classification system
    Lance A Rettig
    Methodist Sports Medicine Center, 201 Pennsylvania Pkwy, Ste 235, Indianapolis, IN
    J Shoulder Elbow Surg 17:97-105. 2008
    ..retrospectively classified the preoperative radiographs of 18 patients (21 elbows) who had undergone elbow debridement and capsular release through a lateral collateral ligament preserving approach...
  46. ncbi Arthroscopic debridement and capsular release for glenohumeral osteoarthritis
    David P Richards
    Institute for Bone and Joint Disorders, Phoenix, Arizona, USA
    Arthroscopy 23:1019-22. 2007
    ..This report outlines our technique of arthroscopic debridement and capsular release...
  47. ncbi Molecular diagnosis of Raoultella planticola infection of a surgical site
    R Wolcott
    Southwest Regional Wound Care Center, Lubbock, Texas, USA
    J Wound Care 19:329-32. 2010
    ..This pathogen was diagnosed with rapid clinical molecular pathogen diagnostic methods, which allowed an appropriate therapy to be implemented, thereby improving prognosis...
  48. doi The value of debridement and Vacuum-Assisted Closure (V.A.C.) Therapy in diabetic foot ulcers
    Magnus Eneroth
    Department of Orthopaedics, Malmo University Hospital, 205 02 Malmo, Sweden
    Diabetes Metab Res Rev 24:S76-80. 2008
    ..This presentation will focus on debridement and V.A.C. Therapy, two treatments widely used in patients with diabetes and foot ulcers.
  49. doi Enzymatic wound debridement
    Janet Ramundo
    Houston, Texas, USA
    J Wound Ostomy Continence Nurs 35:273-80. 2008
    Clinical experience and existing research strongly support debridement as a necessary component of wound bed preparation when slough or eschar is present...
  50. doi Evolution in the treatment of mediastinitis: single-center experience
    Marisa De Feo
    Department of Cardiothoracic Sciences, Second University of Naples, V Monaldi Hospital, Naples, Italy
    Asian Cardiovasc Thorac Ann 19:39-43. 2011
    ..In group B (83 patients; 1995-2002), the treatment was in 3 steps: wound debridement and closed irrigation for 10 days; in case of failure, open dressing with sugar and hyperbaric treatment; ..
  51. doi The fate of acute methicillin-resistant Staphylococcus aureus periprosthetic knee infections treated by open debridement and retention of components
    Thomas Bradbury
    The Emory Orthopaedics Center, 59 Executive Park South, Atlanta, Georgia, USA
    J Arthroplasty 24:101-4. 2009
    The success of open irrigation and debridement with component retention (ODCR) for acute periprosthetic knee joint infection varies widely. The species and virulence of the infecting organism have been shown to influence outcome...
  52. ncbi Cartilage transplantation techniques for talar cartilage lesions
    Matthew E Mitchell
    Casper Orthopedic Associates, Casper, WY, USA
    J Am Acad Orthop Surg 17:407-14. 2009
    ..More recent restorative techniques developed for the knee have been adapted for the ankle, such as autologous chondrocyte implantation and matrix-induced autologous chondrocyte implantation...
  53. doi Maggot debridement therapy with Lucilia cuprina: a comparison with conventional debridement in diabetic foot ulcers
    Aaron G Paul
    Department of Orthopaedic Surgery, Sarawak General Hospital, Sarawak, Malaysia
    Int Wound J 6:39-46. 2009
    This is prospective case-control study of more than 18 months performed to assess the effectiveness of maggot debridement therapy (MDT) with the sterile larvae of Lucilia cuprina (a tropical blowfly maggot) for the treatment of diabetic ..
  54. ncbi Quantifying bacterial bioburden during negative pressure wound therapy: does the wound VAC enhance bacterial clearance?
    Tonja Weed
    Department of Plastic Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Ann Plast Surg 52:276-9; discussion 279-80. 2004
    ..Furthermore, bacterial colonization increased significantly with Wound VAC therapy and remained in a range of 10(4)-10(6). Despite this finding, the beneficial effects of this treatment modality on wound healing were noted in most cases...
  55. ncbi Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial
    A Veves
    Joslin Beth Israel Deaconess Foot Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 24:290-5. 2001
    ..We assessed in a randomized prospective trial the effectiveness of Graftskin, a living skin equivalent, in treating noninfected nonischemic chronic plantar diabetic foot ulcers...
  56. ncbi Treatment of hematogenous pyogenic vertebral osteomyelitis with anterior debridement and primary bone grafting
    S E Emery
    Department of Orthopaedics, School of Medicine, Case Western Reserve University, Cleveland, Ohio
    Spine (Phila Pa 1976) 14:284-91. 1989
    ..Data from 21 patients with greater than 2-year follow-up is presented in this report. Surgical debridement via an anterior approach was performed in all 21 patients...
  57. ncbi The management of peri-prosthetic infection in total joint arthroplasty
    A D Toms
    Princess Elizabeth Orthopaedic Centre, Exeter, Devon EX2 5DW, UK
    J Bone Joint Surg Br 88:149-55. 2006
  58. ncbi Chronic venous insufficiency and venous leg ulceration
    I C Valencia
    Department of Dermatology, University of Miami, Miami, Florida 33136, USA
    J Am Acad Dermatol 44:401-21; quiz 422-4. 2001
    ....
  59. doi Outcome and predictors of treatment failure in early post-surgical prosthetic joint infections due to Staphylococcus aureus treated with debridement
    F Vilchez
    Department of Orthopedics of Hospital Clínic of Barcelona, Spain
    Clin Microbiol Infect 17:439-44. 2011
    Experience with debridement and prosthesis retention in early prosthetic joint infections (PJI) due to Staphylococcus aureus is scarce. The present study aimed to evaluate the outcome and predictors of failure...
  60. ncbi Tuberculosis of the spine: a review
    Anil K Jain
    University College of Medical Sciences, Delhi 110095, India
    Clin Orthop Relat Res 460:39-49. 2007
    ..The correction of healed kyphosis requires multistage surgery and is fraught with complications. Prospective studies are needed to define surgical approach, steps, stages, problems, and obstacles to correct severe kyphosis in spinal TB...
  61. ncbi Toward a common language: surgical wound bed preparation and debridement
    Mark Granick
    Department of Plastic Surgery, New Jersey Medical School UMDNJ, Newark, New Jersey, USA
    Wound Repair Regen 14:S1-10. 2006
    ..Another is through sharing our concepts of surgical debridement as it is applied to different wounds by a variety of surgical disciplines...
  62. ncbi Arthroscopic debridement for the treatment of osteoarthritis of the knee: 2- and 5-year results
    Jason Fond
    Nirschl Orthopedic and Sportsmedicine Clinic, The Virginia Hospital Center Arlington, and Georgetown University, Arlington, Virginia, USA
    Arthroscopy 18:829-34. 2002
    The purpose of this study was to evaluate the effect that arthroscopic debridement in osteoarthritic knees has on patient satisfaction and function.
  63. ncbi Longitudinal changes in spinal deformity after anterior spinal surgery for tuberculosis of the spine in adults. A comparative analysis between radical and debridement surgery
    S S Upadhyay
    Duchess of Kent Children s Hospital, Hong Kong
    Spine (Phila Pa 1976) 19:542-9. 1994
    ..Seventy-one patients had radical surgery; the remaining 34 underwent debridement surgery...
  64. pmc Larval therapy for leg ulcers (VenUS II): randomised controlled trial
    Jo C Dumville
    Department of Health Sciences, University of York, York YO10 5DD, UK
    BMJ 338:b773. 2009
    To compare the clinical effectiveness of larval therapy with a standard debridement technique (hydrogel) for sloughy or necrotic leg ulcers.
  65. doi Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America
    Douglas R Osmon
    Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Infect Dis 56:e1-e25. 2013
    ..and opinion-based recommendations for the diagnosis and management of patients with PJI treated with debridement and retention of the prosthesis, resection arthroplasty with or without subsequent staged reimplantation, 1-..
  66. doi A conservative and minimally invasive approach to necrotizing pancreatitis improves outcome
    Hjalmar C van Santvoort
    Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands
    Gastroenterology 141:1254-63. 2011
    ..We performed a prospective multicenter study of treatment outcomes among patients with necrotizing pancreatitis...
  67. pmc Failure of irrigation and débridement for early postoperative periprosthetic infection
    Thomas K Fehring
    OrthoCarolina, PA, Hip and Knee Center, 2001 Vail Avenue, Suite 200 A, Charlotte, NC 28207, USA
    Clin Orthop Relat Res 471:250-7. 2013
    ..Mitigating factors include organism type, host factors, and timing of intervention. While the influence of organism type and host factors has been clarified, the timing of intervention remains unclear...
  68. doi In vivo confocal microscopic findings of corneal wound healing after corneal epithelial debridement in diabetic vitrectomy
    Wei Li Chen
    Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
    Ophthalmology 116:1038-47. 2009
    To study healing of corneal wounds using in vivo confocal microscopy in patients who received corneal epithelial debridement during pars plana vitrectomy for proliferative diabetic retinopathy and to investigate risk factors for delayed ..
  69. doi Collagenase Santyl ointment: a selective agent for wound debridement
    Lei Shi
    Healthpoint Ltd, Fort Worth, Texas 76107, USA
    J Wound Ostomy Continence Nurs 36:S12-6. 2009
    Enzymatic debridement is a frequently used technique for removal of necrotic tissue from wounds...
  70. pmc Can this prosthesis be saved?: implant salvage attempts in infected primary TKA
    Jeremy Gardner
    Department of Orthopaedic Surgery, University of Minnesota Medical School, Minneapolis, MN, USA
    Clin Orthop Relat Res 469:970-6. 2011
    ..We sought to identify factors that would predict control of infection after ODPE...
  71. ncbi Biofilm maturity studies indicate sharp debridement opens a time- dependent therapeutic window
    R D Wolcott
    Southwest Regional Wound Care Center, Lubbock, TX, USA
    J Wound Care 19:320-8. 2010
    ..To investigate the hypothesis that newly formed wound biofilms (or bioburdens) are more susceptible to antimicrobial treatment...
  72. ncbi Arthroscopic debridement without radial head excision of the osteoarthritic elbow
    Edward W Kelly
    Minnesota Orthopedic Specialists, Minneapolis, Minnesota 55454, USA
    Arthroscopy 23:151-6. 2007
    ..short-term clinical outcomes of patients with osteoarthritis of the elbow joint, including grade III or IV radiocapitellar arthritis, treated with debridement of the radial head in conjunction with arthroscopic ulnohumeral arthroplasty.
  73. pmc Debridement and closed packing for sterile or infected necrotizing pancreatitis: insights into indications and outcomes in 167 patients
    J Ruben Rodriguez
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann Surg 247:294-9. 2008
    ..To examine the surgical indications and clinical outcomes of a large cohort of patients with necrotizing pancreatitis...
  74. ncbi Kinetics of keratocyte proliferation in response to epithelial debridement
    J D Zieske
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA
    Exp Eye Res 72:33-9. 2001
    Over the past 40 years, several groups have shown that epithelial debridement results in the death of keratocytes subjacent to the wound area. More recently this cell death has been shown to involve apoptosis...
  75. doi A rifampicin-containing antibiotic treatment improves outcome of staphylococcal deep sternal wound infections
    Bettina Khanlari
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    J Antimicrob Chemother 65:1799-806. 2010
    ..Deep sternal wound infection (DSWI) is a severe complication after cardiac surgery, mostly caused by staphylococci. Little is known about the optimal antibiotic management...
  76. ncbi The incidence of deep prosthetic infections in a specialist orthopaedic hospital: a 15-year prospective survey
    J E Phillips
    Royal Orthopaedic Hospital, Bristol Road South, Northfield, Birmingham B31 2AP, UK
    J Bone Joint Surg Br 88:943-8. 2006
    ..These results also illustrate the advantages of conducting joint replacement surgery in the isolation of a specialist hospital...
  77. ncbi The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: a 4- to 6-year symptomatic follow-up
    Robert W Jackson
    George Truett James Orthopaedic Institute, Department of Orthopaedics, Baylor University Medical Center, Dallas, Texas 75246, USA
    Arthroscopy 19:13-20. 2003
    A clinically and arthroscopically oriented staging system based on the severity of the degenerative process has been used in the assessment of the results of arthroscopic lavage and debridement of osteoarthritic (OA) knees.
  78. ncbi Necrotising infections of soft tissues--a clinical profile
    Gurpreet Singh
    Eur J Surg 168:366-71. 2002
    ..To study the clinical profile and outcome of patients with necrotising soft-tissue infections...
  79. ncbi Maggot versus conservative debridement therapy for the treatment of pressure ulcers
    Ronald A Sherman
    Department of Pathology, University of California, Irvine, California 92697 4800, USA
    Wound Repair Regen 10:208-14. 2002
    ..b>Debridement and wound healing could be quantified for 43 maggot-treated wounds and 49 conventionally treated wounds...
  80. doi Treatment of osteochondral defects of the talus
    C J A van Bergen
    Department of Orthopaedic Surgery, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DD Amsterdam, The Netherlands
    Rev Chir Orthop Reparatrice Appar Mot 94:398-408. 2008
    ..The primary surgical treatment of defects up to 15 mm in diameter consists of arthroscopic debridement and bone marrow stimulation...
  81. ncbi Clinical outcomes of noninfectious sternal dehiscence after median sternotomy
    Vanessa A Olbrecht
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 4618, USA
    Ann Thorac Surg 82:902-7. 2006
    ....
  82. doi Predictive value of inflammatory markers for irrigation and debridement of acute TKA infection
    Louis S Stryker
    OrthoCarolina Hip and Knee Center, 2001 Vail Ave, Ste 200, Charlotte, NC 28207, USA
    Orthopedics 36:765-70. 2013
    ..is not entirely clear what value preoperative CRP and ESR have in predicting outcomes following irrigation and debridement with insert exchange for acute hematogenous total knee arthroplasty infection...
  83. pmc Synovectomy, debridement, and continuous irrigation for infected total knee arthroplasty
    Hiroshi Tsumura
    Department of Orthopedic Surgery, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Oita, 879 5593, Japan
    Int Orthop 29:113-6. 2005
    ..They underwent synovectomy, debridement, and continuous irrigation without implant removal. Continuous irrigation was maintained for 7-29 days...
  84. pmc Anterior debridement and bone grafting of spinal tuberculosis with one-stage instrumentation anteriorly or posteriorly
    Jie Zhao
    Department of Orthopaedics, Changhai Hospital, 174 Changhai Road, Shanghai, 200433, People s Republic of China
    Int Orthop 31:859-63. 2007
    ..2000 and 2004, 40 cases (average age 38, range 16-65 years) of spinal tuberculosis were treated with anterior debridement and iliac bone graft with one-stage anterior or posterior instrumentation in our unit...
  85. ncbi How effective is surgical therapy compared with nonsurgical debridement?
    Lisa J A Heitz-Mayfield
    The University of Western Australia, Crawley, Australia
    Periodontol 2000 37:72-87. 2005
  86. ncbi Enzymatic versus autolytic debridement of chronic leg ulcers: a prospective randomised trial
    M Konig
    Dermatology Praxis, Gundelfingen, Germany
    J Wound Care 14:320-3. 2005
    ....
  87. pmc Percutaneous endoscopic discectomy and drainage for infectious spondylitis
    Shih Chieh Yang
    Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 5, Fu Shin Street, Kweishan, 333 Taoyuan, Taiwan
    Int Orthop 31:367-73. 2007
    ..All patients reported immediate back pain relief except for two, who required anterior debridement and fusion one week and two weeks later, respectively...
  88. doi Early prosthetic hip joint infection treated with debridement, prosthesis retention and biofilm-active antibiotics: functional outcomes, quality of life and complications
    C Aboltins
    Department of Infectious Diseases, St Vincent s Hospital, Melbourne, Victoria, Australia
    Intern Med J 43:810-5. 2013
    Patients treated for early prosthetic joint infection (PJI) with surgical debridement, prosthesis retention and biofilm-active antibiotics, such as rifampicin or fluoroquinolones have a rate of successful infection eradication that is ..
  89. ncbi Neonatal gut injury and infection rate: impact of surgical debridement on outcome
    Renu Sharma
    Division of Neonatology, Department of Pediatrics, University of Florida at Jacksonville, Jacksonville, FL, USA
    Pediatr Surg Int 21:977-82. 2005
    ..non-concurrent infections than infants without G-INJ in a neonatal intensive care unit (NICU); (2) surgical debridement (DEB) of infants with severe G-INJ is associated with lower infectious morbidity and mortality...
  90. ncbi Reconstruction of segmental bone defects due to chronic osteomyelitis with use of an external fixator and an intramedullary nail
    Mehmet Kocaoglu
    Department of Orthopaedics and Traumatology, Istanbul Medical School, Istanbul University, Capa, 34390, Istanbul, Turkey
    J Bone Joint Surg Am 88:2137-45. 2006
    ....
  91. doi New techniques for wound debridement
    Brijesh M Madhok
    Department of Vascular Surgery, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
    Int Wound J 10:247-51. 2013
    b>Debridement is a crucial component of wound management...
  92. ncbi Effect of painful keratoses debridement on foot pain, balance and function in older adults
    Karen R Balanowski
    Department of Podiatry, Lothian Primary Care NHS Trust, Springwell House, Ardmillan Terrace, Edinburgh EH11 2JL, UK
    Gait Posture 22:302-7. 2005
    ..Pain is often associated with plantar hyperkeratoses, which are easily treated by podiatrists. Currently, there is no data defining the effect this treatment has on balance or functional ability...
  93. ncbi Debridement and wound closure of open fractures: the impact of the time factor on infection rates
    D J Crowley
    Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, United Kingdom
    Injury 38:879-89. 2007
    ..b>Debridement and wash-out of the wound, followed by stabilisation of the bony elements and closure of the soft-tissue ..
  94. ncbi Thoracic and lumbar tuberculous spondylitis treated by posterior debridement, graft placement, and instrumentation: a retrospective analysis in 19 cases
    Feyza Karagoz Guzey
    Department of Neurosurgery, SSK Vakif Gureba Training Hospital, Istanbul, Turkey
    J Neurosurg Spine 3:450-8. 2005
    ..The aim of the present study was to assess the efficacy of posterior debridement and the placement of posterior instrumentation for the treatment of patients with thoracic and lumbar ..
  95. ncbi Osteochondral lesions of the talus: results of repeat arthroscopic debridement
    Nicholas Savva
    Brisbane Foot and Ankle Centre, Brisbane Private Hospital, Brisbane, Queensland, Australia
    Foot Ankle Int 28:669-73. 2007
    Repeat arthroscopic debridement of osteochondral lesions of the talus has a poor reputation despite a paucity of evidence in the literature.
  96. doi Anterior debridement and fusion followed by posterior pedicle screw fixation in pyogenic spondylodiscitis: autologous iliac bone strut versus cage
    Yong Hun Pee
    Department of Neurosurgery, Wooridul Spine Hospital, Seoul, Korea
    J Neurosurg Spine 8:405-12. 2008
    An anterior approach for debridement and fusion with autologous bone graft has been recommended as the gold standard for surgical treatment of pyogenic spondylodiscitis...
  97. doi Collagenase for enzymatic debridement: a systematic review
    Janet Ramundo
    Emory University Wound Ostomy and Continence Nursing Education Program, Atlanta, Georgia, USA
    J Wound Ostomy Continence Nurs 36:S4-11. 2009
    b>Debridement is an essential component of wound bed preparation. Various techniques of debridement are commonly used in clinical practice...
  98. pmc Canal and isthmus debridement efficacies of two irrigant agitation techniques in a closed system
    L Susin
    Department of Endodontics, School of Dentistry, Medical College of Georgia, Augusta, GA 30912 1129, USA
    Int Endod J 43:1077-90. 2010
    To compare canal and isthmus debris debridement efficacies of the manual dynamic irrigation (MDI) and apical negative pressure (ANP) techniques in the mesial root of mandibular first molars with narrow isthmi, using a closed canal design.
  99. doi Debridement versus re-attachment of acetabular labral tears: A review of the literature and quantitative analysis
    B Haddad
    University College London Hospital, 235 Euston Road, London NW1 2BU, UK
    Bone Joint J 96:24-30. 2014
    ..Of these studies 12 reported a mean rate of good results of 82% (from 67% to 100%) for labral debridement. Of the 16 studies that reported a combination of debridement and re-attachment, five reported a comparative ..
  100. doi Recurrent skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus requiring operative debridement
    Pranavi Sreeramoju
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Surg 201:216-20. 2011
    ..The aim of this study was to examine clinical factors associated with the recurrence of community-onset skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus...
  101. doi The self-adjusting file optimizes debridement quality in oval-shaped root canals
    Gustavo De-Deus
    Veiga de Almeida University, Rio de Janeiro, Brazil
    J Endod 37:701-5. 2011
    ..The aim of the present study was to evaluate the debridement quality of the Self-Adjusting File (SAF) system in oval canals and compare it with the debridement achieved by ..

Research Grants63

  1. PROTEASE MODULATING WOUND DRESSINGS FOR THE TREATMENT OF VENOUS ULCERS
    DAVID VACHON; Fiscal Year: 2006
    ..Available and current treatment regimens, in particularly compression therapy, debridement of necrotic tissue, treatment of edema, and control of infection are believed to reduce recurrence rates from ..
  2. Therapeutic Potential of PARP inhibitor for Acute Pancreatitis
    Latha Paka; Fiscal Year: 2010
    ..Recently, despite the use of less invasive techniques, complications following debridement of necrotic pancreatic tissue are still common and the mortality rate with severe AP is still high...
  3. Development of a Topical Choroid Plexus Factor Product to Accelerate Wound Healin
    CHRISTOPHER GORDON THANOS; Fiscal Year: 2011
    ..The standard of care for these wounds has been unchanged for decades, and remains reduced weight bearing, debridement, antibiotics, and dressings...
  4. Therapeutic Corneal Cross-linking Using Aliphatic Beta-Nitroalcohols
    David C Paik; Fiscal Year: 2013
    ..therapy include the omission of ultraviolet light exposure, the ability to treat thin corneas, no epithelial debridement resulting in less patient discomfort and a lower chance of infection, a dose-response effect, and the ability ..
  5. Development of Cytokine-Inhibiting Gels for Treating Chronic Wounds
    Newell R Washburn; Fiscal Year: 2010
    ..While there is a broad range of treatment options available - ranging from debridement to application of recombinant platelet-derived growth factor - none has proven to be truly effective in ..
  6. Diagnosis of sub-clinical cryptic group A streptococcal myonecrosis
    Amy Evelyn Bryant; Fiscal Year: 2013
    ..In these rapidly progressing "cryptic" infections, mortality is 70- 85%. Survivors undergo extensive surgical debridement including amputations and prolonged hospitalization...
  7. CORNEAL LIPID METABOLISM AND RESPONSE TO INFLAMMATION
    Haydee E P Bazan; Fiscal Year: 2010
    ..b>Debridement of corneal epithelium and anterior stroma in vivo and de-epithelization of corneas in organ culture will be ..
  8. Salivary Biomarkers in the Diagnosis of BRONJ
    Tara L Aghaloo; Fiscal Year: 2013
    ..Therapy ranges from watchful waiting to medical therapy and conservative debridement to hyperbaric oxygen to extensive jaw resection...
  9. Adipose-Derived Stromal/Stem Cell Therapy for Pressure Ulcers
    Xiying Wu; Fiscal Year: 2012
    ..Current treatment of pressure ulcers relies primarily on surgical debridement, hyperbaric oxygen, growth factors, and negative pressure devices...
  10. Multivalent Conjugates of Sonic Hedgehog to Accelerate Diabetic Wound Healing
    WESLEY MICHAEL JACKSON; Fiscal Year: 2012
    ..the standard practice of diabetic ulcer management and to reduce the costly serial effort required for debridement and clinical observation of these slowly healing wounds...
  11. A comparative efficacy study: treatments of non-healing diabetic foot ulcers
    Roslyn R Isseroff; Fiscal Year: 2013
    ..Even with the best standard of care, which is debridement of non-viable tissue, off-loading of weight-bearing and treatment of infection, only 30% of diabetic foot ..
  12. Improved manufacture of bone transport plates
    TIMOTHY MULONE; Fiscal Year: 2009
    ..Furthermore, segmental bone loss may result from blast injuries, high impact trauma, or repeated surgical debridement for treatment of chronic osteomyelitis of the mandible...
  13. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2013
    ..and Smad signaling pathway have distinct roles in mediating TGF-[unreadable] signaling of corneal epithelium debridement and keratectomy, respectively...
  14. 2012 New Insights into Coagulation
    Eleanor Pollak; Fiscal Year: 2012
    ..The utilization of leeches in wound debridement will be addressed by Eleanor Pollak along with a senior fellow from the University of Pennsylvania Division of ..
  15. Smad3 inhibitors for ophthalmic applications
    Ching Yuan; Fiscal Year: 2010
    ..The fibrosis and neovascularization by alkaline burn, mechanical debridement and trabeculectomy surgery will be conducted on rabbit cornea and conjunctiva for the evaluation of Smad3 ..
  16. A Portable Wound Hemostasis System Using a Hydrogel Polymeric Foam
    Edward Rodriguez; Fiscal Year: 2013
    ..If surgical care and debridement is to be preformed promptly, heavy wound contamination can be initially neglected, but it is unclear if doing ..
  17. Molecular Approaches to Reversing Corneal Goblet Cell Hyperplasia
    Mary Ann Stepp; Fiscal Year: 2013
    ..During homeostasis and after small debridement wounds, conventional and compound niche progenitor cells generate progeny that differentiate primarily into ..
  18. Image Guidance Method for Diabetic Foot Surgery
    IRVING WEINBERG; Fiscal Year: 2010
    ..Follow-on applications for the technology to be developed in this project include decubitus ulcer debridement, and other wound care challenges. Unlike prior imaging approaches that employed exogenous contrast materials (e...
  19. Molecular mechanisms of corneal recurrent erosion formation
    Mary Ann Stepp; Fiscal Year: 2013
    ..characterized a model for the study of recurrent corneal erosions in mice that uses a dulled blade to create debridement wounds...
  20. Biofilms and Immunity in Chronic Wounds
    Daniel J Wozniak; Fiscal Year: 2013
    ..a newly developed porcine full thickness burn chronic wound model and explanted human tissue from burn wound debridement to investigate biofilm persistent infections caused by P. aeruginosa and S. aureus...
  21. A nanotherapeutic approach to combat staphylococcal biofilm-associated infection
    Mark S Smeltzer; Fiscal Year: 2011
    ..to treat the growing problem of staphylococcal biofilm-associated infection, perhaps to the point that removal of infected devices and/or surgical debridement will become a therapeutic option rather than an imperative.
  22. Corneal epithelial adhesion:morphology and biochemistry
    VICKERY E TRINKAUS-RANDALL; Fiscal Year: 2012
    ..The goal of this proposal is to determine how epithelial debridement, along with other factors mediates the activation of purinergic receptors in the cornea...
  23. Stimuli Responsive Topical Gels for Mechanically Assisted Wound Debridement
    Aristidis Veves; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Debridement of dead, damaged and/or infected tissue from thermal burn wounds and a certain subset of ischemic and necrotic diabetic foot wounds is a commonly utilized wound preparation modality ..
  24. A novel therapeutic for the treatment of persistent corneal epithelial defects
    Bennie H Jeng; Fiscal Year: 2010
    ..in the healing of persistent corneal epithelial defects (PED) that have resulted from corneal epithelial debridement during diabetic vitrectomy surgery...
  25. Biological Methods for Enhancing Wound Healing Properties
    Bruce A Webb; Fiscal Year: 2013
    ..This proposal seeks to improve and develop new capabilities of a biological treatment of such wounds, maggot debridement therapy (MDT) that is effective but underutilized...
  26. Nitric Oxide Releasing Topical Gel for Burn Wound Healing
    ANJAL SHARMA; Fiscal Year: 2007
    ..therapeutic for partial thickness burns, and potentially in wound healing for full thickness burns after debridement and also prior to skin grafting...
  27. Subgingival Drug Delivery for Periodontitis Prevention and Treatment
    MARTYN DARBY; Fiscal Year: 2009
    ..The current standard of care for periodontitis is mechanical debridement (scaling and root planing)...
  28. Compact Debridement and Treatment Delivery Device for Dermal Wound Care
    ANDREA WESSER; Fiscal Year: 2011
    ..Often times, a painful but the most popular method, mechanical debridement, relies on wet dressings that then dry and cling to the wound, so that necrotic tissue is violently ripped off...
  29. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2007
    ..treatment (light dose yet to be determined after completion of Phase l/ll trial), and on Day 5 by endoscopic debridement. Tumor response and symptom relief (cough, dyspnea, hemoptysis) will be determined at Day 5, one month and ..
  30. Tissue Engineering by a Non-Biologic Skin Substitute
    WILLIAM SEARE; Fiscal Year: 2005
    ..promote vascularity, including larger caliber vessels, reduce the amount of acute inflammation, provide debridement (less residual tattoo ink) and promote a thicker and stratified neo-epithelium, In light of our preliminary ..
  31. EFFECTS OF TREATMENT ON EARLY ONSET PERIODONTITIS
    Frank Roberts; Fiscal Year: 2003
    ..rapidly progressive) periodontitis patients and understanding the host response mechanisms involved in tooth debridement in this patient group...
  32. Iron Uptake and Mucormycosis Pathogenesis
    Ashraf Ibrahim; Fiscal Year: 2005
    ..Despite aggressive therapy, which includes disfiguring surgical debridement and adjunctive toxic antifungal therapy, the overall mortality of mucormycosis remains >50%, and it ..
  33. Topical negative pressure dressings for the prevention of chronic wound biofilm
    GUY ORGAMBIDE; Fiscal Year: 2009
    ..Therefore, chemical or mechanical debridement, removing necrotic tissue and biofilm itself, represents an essential first step toward returning the wounded ..
  34. Osteopuncture for OA-Associated Knee Pain & Disability
    Debra Weiner; Fiscal Year: 2005
    ..Glucosamine and chondroitin, intra-articular corticosteroids and hyaluronic acid, and arthroscopic debridement and lavage have either been only modestly effective or not helpful at all...
  35. Therapeutic scFv antibody for human periodontitis
    YEN TUNG TENG; Fiscal Year: 2005
    ..Conventional periodontal treatment relies on mechanical debridement of the affected teeth and gums by scaling, root planning and surgeries, sometimes combined with antibiotic ..
  36. Photodynamic Therapy for Endodontic Disinfection
    NIKOLAOS SOUKOS; Fiscal Year: 2009
    ..that are left behind within the root canal due to the complexity of the root canal system that makes complete debridement with instrumentation and irrigation alone almost impossible...
  37. Development of a Debridement Device Using Ice Particles
    LUIZ DA SILVA; Fiscal Year: 2001
    ..In the U.S. approximately 20,000 patients undergo some form of bum debridement. The standard treatment for deep dermal bums is tangential excision of the burn eschar; the tissue is ..
  38. Wound Repair by Stimulation of Specific Tissue Ingrowth
    Weiliam Chen; Fiscal Year: 2007
    ..Most current treatments (e.g., off-weighting, debridement and ischemic reversal) provide only limited benefits...
  39. OXIDATIVE STRESS EFFECT ON DEGRADATION DEBRIS
    John Schmitz; Fiscal Year: 1999
    ..has been reported including an unpredictable foreign body reaction which has necessitated surgical exploration, debridement, and removal of the implants...
  40. A Unified Surgical Instrument System for Periodontal Minimally Invasive Surgery
    STEPHEN HARREL; Fiscal Year: 2007
    ..encountered with current visualization systems and (2) the fabrication of instruments for improved soft tissue debridement through the small surgical opening used with MIS...
  41. Uptake of Fluoroquinolones and Tetracyclines by Gingiva
    John Walters; Fiscal Year: 2003
    ..gingivalis. Their ability to invade epithelial cells makes them difficult to treat by mechanical debridement alone, but antimicrobial agents enhance their elimination...
  42. Smart Fluid Devices for Physical Rehabilitation
    Katherine Rudolph; Fiscal Year: 2003
    ..study in people with osteoarthritis of the knee and quadriceps femoris weakness following arthroscopic debridement. Functional outcome measures (Get-up-and-go test and timed-stair climbing) and three dimensional motion ..
  43. TNFR:Fc Gene Transfer for Treatment of Periodontitis
    William Giannobile; Fiscal Year: 2006
    ..S. population, and is treated mainly by local debridement or surgery of the affected teeth...
  44. TEA-CO2 DEBRIDEMENT OF BURN ESCHAR (7130-260)
    David Rosen; Fiscal Year: 1991
    ..of utilizing commercially available repetitively-pulsed CO 2 TEA laser technology for the precise, controlled debridement of burn eschar in the treatment of full thickness dermal burns...
  45. New Nanoparticles for Antimicrobial Therapy of Dental Plaque Related Diseases
    J Wharton; Fiscal Year: 2006
    ..microorganisms, by drilling away of infected enamel and dentine for caries lesions, or by root surface debridement in chronic periodontitis, a labor intensive and unpleasant procedure which scrapes the plaque away from inside ..
  46. WOUND HEALING IN THE CORNEAL STROMA
    Takayuki Nagasaki; Fiscal Year: 2003
    ..The injury will consist of a small circular epithelial debridement or the introduction of hydrogen ions by iontophoresis over a 0.4 mm circle, both of which are reproducible...
  47. Antimicrobial Laser
    David Harris; Fiscal Year: 2005
    ..Most common are laser root canal sterilization and laser sulcular debridement. Although there is overwhelming evidence that laser treatment is bactericidal, current laser systems are ..
  48. The impact of aging on the inflammatory response
    Robert Stout; Fiscal Year: 2007
    ..Upon successful debridement of the wound, neutrophils apoptose and are phagocytized by macrophages and the macrophages, fibroblasts, and ..
  49. Protease Indicator for Chronic Wound Management
    Irwin Cohen; Fiscal Year: 2006
    ..These excessive proteases can be lowered by radical surgical debridement of the wound to promote healing...
  50. WOUND STERILIZING FACTORS FROM MEDICINAL MAGGOTS
    Ronald Sherman; Fiscal Year: 2001
    ..investigation which is a natural extension of six years of clinical research I have conducted utilizing maggot debridement therapy...
  51. LOCAL ANTIBIOTIC THERAPY OF OSTEOMYELITIS
    CLAYTON PERRY; Fiscal Year: 1990
    ..In addition to antibiotic therapy all patients will require surgical management, eg: debridement; soft tissue coverage; and stabilization of nonunions...
  52. OPTICAL DETECTION OF INTRAVENOUS INFILTRATION
    LEONARD WINCHESTER; Fiscal Year: 2000
    ..Severe infiltration may lead to necrosis requiring skin debridement, skin grafting, or amputation...
  53. TRANSPLANTATION OF THE RETINAL PIGMENT EPITHELIUM
    Lucian Del Priore; Fiscal Year: 2000
    ..from applicant's abstract): The purpose of this research is to extend the understanding of the effects of RPE debridement and subsequent RPE cell transplantation on the morphologic changes on the retina and choriocapillaris...
  54. CELL SIGNAL TRANSDUCTION IN CORNEAL WOUND HEALING
    Haydee Bazan; Fiscal Year: 2006
    ..The debridement of the corneal epithelial layer will be used as a model of wound healing, complemented by in vitro migration ..
  55. Burn depth profiling using photoacoustic analysis
    JOHN VIATOR; Fiscal Year: 2003
    ..This profile would allow clinical management of the wound, including optimal debridement of the necrotic tissue...
  56. PIGMENT EPITHELIUM REMOVAL AND TRANSPLANTATION
    Marco Zarbin; Fiscal Year: 2003
    ..IV: Assess long-term viability of syngeneic RPE sheet transplants onto damaged Bruch's membrane using a published in vivo RPE debridement model.
  57. Local Angiogenic Therapy for Diabetic Ulcers
    Harold Brem; Fiscal Year: 2006
    ..Support from this proposal will allow the applicant to use knowledge from the fields of gene therapy, angiogenesis and wound healing to develop a safe angiogenic gene therapy for diabetic foot ulcers. ..
  58. Local Angiogenic Gene Therapy/VEGF/Treat Diabetic Ulcers
    Harold Brem; Fiscal Year: 2003
    ..In addition, we will analyze the wound fluid in order to determine the temporal expression of VEGF in a diabetic ulcer. ..
  59. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  60. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  61. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..