cryosurgery

Summary

Summary: The use of freezing as a special surgical technique to destroy or excise tissue.

Top Publications

  1. ncbi Immunologic response to cryoablation of breast cancer
    Michael S Sabel
    University of Michigan, 3304 Cancer Center, East Medical Center, 1500 East Medical Center, Ann Arbor, MI 48109 0932, USA
    Breast Cancer Res Treat 90:97-104. 2005
  2. pmc Cryoablation or radiofrequency ablation of the small renal mass : a meta-analysis
    David A Kunkle
    Department of Urologic Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer 113:2671-80. 2008
  3. ncbi Focal cryotherapy for localized prostate cancer: a report from the national Cryo On-Line Database (COLD) Registry
    John F Ward
    Department of Urology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    BJU Int 109:1648-54. 2012
  4. ncbi Intralesional cryosurgery enhances the involution of recalcitrant auricular keloids: a new clinical approach supported by experimental studies
    Yaron Har-Shai
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Wound Repair Regen 14:18-27. 2006
  5. ncbi Prospective trial of curettage and cryosurgery in the management of non-facial, superficial, and minimally invasive basal and squamous cell carcinoma
    Johann M Peikert
    Department of Dermatology, Luther Midelfort, Mayo Health System, Eau Claire, WI 54701, USA
    Int J Dermatol 50:1135-8. 2011
  6. ncbi Minimally-invasive thermal ablation of early-stage breast cancer: a systemic review
    Z Zhao
    Department of Medical Information, Chongqing Medical University, Chongqing 400016, China
    Eur J Surg Oncol 36:1149-55. 2010
  7. ncbi Focal cryosurgery: encouraging health outcomes for unifocal prostate cancer
    Erica H Lambert
    Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Urology 69:1117-20. 2007
  8. ncbi The "male lumpectomy": focal therapy for prostate cancer using cryoablation results in 48 patients with at least 2-year follow-up
    Gary Onik
    Department of Radiology and Urology, Division of Surgical Imaging, Center for Surgical Advancement, Celebration Health Florida Hospital, Celebration, FL 34747, USA
    Urol Oncol 26:500-5. 2008
  9. ncbi A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer
    Bryan J Donnelly
    Department of Surgery, Tom Baker Cancer Center, Suite 212, 1011 Glenmore Trail SW, Calgary, Alberta T2V 4R6, Canada
    Cancer 116:323-30. 2010
  10. ncbi An evaluation of patient selection criteria on predicting progression-free survival after primary focal unilateral nerve-sparing cryoablation for prostate cancer: recommendations for follow up
    Matthew D Truesdale
    Department of Urology, Columbia University Medical Center, New York, NY, USA
    Cancer J 16:544-9. 2010

Detail Information

Publications362 found, 100 shown here

  1. ncbi Immunologic response to cryoablation of breast cancer
    Michael S Sabel
    University of Michigan, 3304 Cancer Center, East Medical Center, 1500 East Medical Center, Ann Arbor, MI 48109 0932, USA
    Breast Cancer Res Treat 90:97-104. 2005
    ..b>Cryosurgery initiates inflammation and leaves tumor-specific antigens intact, which may induce an anti-tumor immune ..
  2. pmc Cryoablation or radiofrequency ablation of the small renal mass : a meta-analysis
    David A Kunkle
    Department of Urologic Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer 113:2671-80. 2008
    ..The authors of this report performed a comparative meta-analysis evaluating cryoablation and RFA as primary treatment for SRMs...
  3. ncbi Focal cryotherapy for localized prostate cancer: a report from the national Cryo On-Line Database (COLD) Registry
    John F Ward
    Department of Urology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    BJU Int 109:1648-54. 2012
    ..Herein we present the largest retrospective registry report of men treated with sub-total prostate cryotherapy in order to begin to understand how this treatment is being applied despite the paucity of data...
  4. ncbi Intralesional cryosurgery enhances the involution of recalcitrant auricular keloids: a new clinical approach supported by experimental studies
    Yaron Har-Shai
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Wound Repair Regen 14:18-27. 2006
    ..behavior measurements, and histological studies were performed in swine muscle specimens after intralesional cryosurgery ex vivo...
  5. ncbi Prospective trial of curettage and cryosurgery in the management of non-facial, superficial, and minimally invasive basal and squamous cell carcinoma
    Johann M Peikert
    Department of Dermatology, Luther Midelfort, Mayo Health System, Eau Claire, WI 54701, USA
    Int J Dermatol 50:1135-8. 2011
    As a variation of the curettage and destruction technique, cryosurgery can be used in place of electrodesiccation for the destructive component when managing superficial basal and squamous cell carcinomas...
  6. ncbi Minimally-invasive thermal ablation of early-stage breast cancer: a systemic review
    Z Zhao
    Department of Medical Information, Chongqing Medical University, Chongqing 400016, China
    Eur J Surg Oncol 36:1149-55. 2010
    ..Minimally-invasive thermal ablation techniques provide an effective approach for local destruction of solid tumor. A novel application is the use for treatment of early-stage breast carcinoma...
  7. ncbi Focal cryosurgery: encouraging health outcomes for unifocal prostate cancer
    Erica H Lambert
    Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Urology 69:1117-20. 2007
    ..We report our safety and efficacy experience of focal cryoablation of the prostate to maintain potency and preserve genitourinary function in men with localized, unifocal disease...
  8. ncbi The "male lumpectomy": focal therapy for prostate cancer using cryoablation results in 48 patients with at least 2-year follow-up
    Gary Onik
    Department of Radiology and Urology, Division of Surgical Imaging, Center for Surgical Advancement, Celebration Health Florida Hospital, Celebration, FL 34747, USA
    Urol Oncol 26:500-5. 2008
    ..This raises the question of whether these patients can be identified and treated with a limited "lumpectomy" or focal cancer treatment...
  9. ncbi A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer
    Bryan J Donnelly
    Department of Surgery, Tom Baker Cancer Center, Suite 212, 1011 Glenmore Trail SW, Calgary, Alberta T2V 4R6, Canada
    Cancer 116:323-30. 2010
    ..The authors of this report conducted a randomized, unblinded, noninferiority trial to compare cryoablation with external beam radiotherapy in these patients...
  10. ncbi An evaluation of patient selection criteria on predicting progression-free survival after primary focal unilateral nerve-sparing cryoablation for prostate cancer: recommendations for follow up
    Matthew D Truesdale
    Department of Urology, Columbia University Medical Center, New York, NY, USA
    Cancer J 16:544-9. 2010
    ..We report focal cryotherapy outcome data and evaluate the accuracy of the 2007 Task Force patient selection criteria at predicting disease recurrence...
  11. ncbi Intralesional cryosurgery for the treatment of hypertrophic scars and keloids following aesthetic surgery: the results of a prospective observational study
    Yaron Har-Shai
    The Bruce Rappaport Faculty of Medicine, Unit of Plastic Surgery, Carmel Medical Center, Israel Institute of Technology, Technion, Haifa, Israel
    Int J Low Extrem Wounds 7:169-75. 2008
    ..Intralesional cryosurgery for the treatment of such scars has been introduced...
  12. ncbi Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial
    Joseph Jorizzo
    Department of Dermatology, Clinical Sciences Building 9th Floor, Wake Forest University School of Medicine, Winston Salem, NC 27157 1071, USA
    Arch Dermatol 140:813-6. 2004
    No long-term randomized controlled clinical trial has compared the efficacy of cryosurgery alone vs cryosurgery following fluorouracil applications for the treatment of actinic keratosis.
  13. pmc Expression of CD44v6 and integrin-β1 for the prognosis evaluation of pancreatic cancer patients after cryosurgery
    Gang Zhou
    Department of Oncology, The GIBH Affiliated Fuda Hospital, Chinese Academy of Sciences, Guangzhou 510305, China
    Diagn Pathol 8:146. 2013
    ..Many previous studies demonstrated that cell adhesion molecules CD44v6 and integrin-β1 had been extensively investigated as potential prognostic markers of various cancers. However, data in PC are scarce...
  14. ncbi In vivo destruction of tumor tissue by cryoablation can induce inhibition of secondary tumor growth: an experimental study
    J J Joosten
    Department of Surgery, University Hospital Nijmegen, The Netherlands
    Cryobiology 42:49-58. 2001
    ..03). CONCLUSIONS: Cryoablation of tumor tissue can result in inhibition of secondary and metastatic tumor growth. A cytokine response induced by cryoablation of tumor tissue may attribute to this feature...
  15. ncbi Cryoablation of unresectable pancreatic cancer
    Stephen J Kovach
    Department of Surgery, University of Rochester Medical Center, Box SURG, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Surgery 131:463-4. 2002
    ..The goal of this study was to evaluate the safety of an intraoperative ultrasound-guided cryosurgical procedure in a phase I study of unresectable pancreatic cancer...
  16. ncbi Salvage therapy for prostate cancer recurrence after radiation therapy
    Jared M Cox
    Division of Urology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Urol Rep 10:199-205. 2009
    ..As these modalities continue to improve and patient selection is optimized, better results will evolve...
  17. pmc Induction of specific cellular and humoral responses against renal cell carcinoma after combination therapy with cryoablation and granulocyte-macrophage colony stimulating factor: a pilot study
    Archana Thakur
    Department of Oncology, Wayne State University, Karmanos Cancer Institute, Detroit, MI, USA
    J Immunother 34:457-67. 2011
    ..These pilot data show that CI can induce robust and brisk cellular and humoral immune responses in patients with metastatic RCC, but requires further evaluation in optimized protocols...
  18. ncbi Pulmonary vein isolation with Mesh Ablator versus cryoballoon catheters: 6-month outcomes
    Robert Hofmann
    Cardiovascular Division, City Hospital Linz, Krankenhausstrasse 9, 4021 Linz, Austria
    J Interv Card Electrophysiol 29:179-85. 2010
    ..We sought to compare the results of pulmonary vein (PV) ablation using the high-density Mesh Ablator catheter (MESH) versus the cryoballoon (CRYO)...
  19. pmc Curettage and cryosurgery for low-grade cartilage tumors is associated with low recurrence and high function
    David G Mohler
    Department of Orthopaedic Surgery, Stanford University Medical Center, 450 Broadway Street, M C 6342, Redwood City, CA 94063, USA
    Clin Orthop Relat Res 468:2765-73. 2010
    ..Curettage with adjuvant cryosurgery has been proposed as an alternative therapy for Grade 1 chondrosarcomas given the generally better function ..
  20. ncbi Salvage prostate cryoablation: initial results from the cryo on-line data registry
    Louis L Pisters
    Department of Urology, M D Anderson Cancer Center, Houston, Texas, USA
    J Urol 180:559-63; discussion 563-4. 2008
    ..We report contemporary outcomes of salvage cryoablation at a large number of centers which have participated in the COLD (Cryo On-Line Data) Registry...
  21. ncbi Cryorecanalization: a new approach for the immediate management of acute airway obstruction
    Martin Hetzel
    Department of Internal Medicine II Pulmonary Medicine, University Medical Center Ulm, Ulm, Germany
    J Thorac Cardiovasc Surg 127:1427-31. 2004
    ..In this study we demonstrate a newly developed cryoprobe allowing recanalization of tumor stenoses during a single intervention...
  22. ncbi Adoptive immunotherapy of breast cancer with lymph node cells primed by cryoablation of the primary tumor
    Michael S Sabel
    University of Michigan, Department of Surgery, Division of Surgical Oncology, 3304 Cancer Center, 1500 East Medical Center, Ann Arbor, MI 48109 0932, USA
    Cryobiology 53:360-6. 2006
    ..Cryoablation prior to surgical resection of breast cancer can be used as a method to generate effector T-cells for adjuvant adoptive cellular immunotherapy...
  23. ncbi Cryosurgery for lung cancer: clinical results and technical aspects
    M O Maiwand
    Department of Thoracic Surgery, Harefield Hospital, Harefield, Middlesex, England
    Technol Cancer Res Treat 3:143-50. 2004
    ..b>Cryosurgery can be used as a method of palliative treatment for both these endobronchial and extrabronchial presentations...
  24. ncbi Cryosurgery for skin cancer: 30-year experience and cure rates
    Emanuel G Kuflik
    UMDNJ New Jersey Medical School, Newark, New Jersey, USA
    Dermatol Surg 30:297-300. 2004
    b>Cryosurgery is capable of destroying nonmelanotic skin cancers, and numerous reports from around the world attest to its efficacy. However, there are few long-term data of large series of patients that were treated in this manner.
  25. ncbi Comparison of health-related quality of life and prostate-associated symptoms after primary and salvage cryotherapy for prostate cancer
    Aristotelis G Anastasiadis
    Department of Urology, Columbia University Health Sciences, 161 Fort Washington Avenue, Herbert Irving Pavilion, 11th Floor, New York, NY 10032, USA
    J Cancer Res Clin Oncol 129:676-82. 2003
    Recent advances in cryosurgery of the prostate have led to the ability to treat tumors successfully with decreased morbidity. The patients' perspectives of this relatively new technique, however, have not yet been addressed...
  26. ncbi Cryo-immunology: a review of the literature and proposed mechanisms for stimulatory versus suppressive immune responses
    Michael S Sabel
    Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Department of Surgery, 3304 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Cryobiology 58:1-11. 2009
    The use of cryosurgery to ablate tumors is expanding, primarily due to its technical ease and minimal morbidity...
  27. ncbi Focal cryosurgery followed by penile rehabilitation as primary treatment for localized prostate cancer: initial results
    David S Ellis
    Urology Associates of North Texas, Arlington, Texas 76012, USA
    Urology 70:9-15. 2007
    ..Further study is warranted...
  28. ncbi Serum cytokine levels in response to hepatic cryoablation
    Shinji Osada
    Surgical Oncology, Gifu University School of Medicine, Gifu City, Japan
    J Surg Oncol 95:491-8. 2007
    ..Cryogenic treatment sometimes stimulates the immune system by releasing intracellular antigens. We evaluated anti-tumor immune response by analyzing alterations in serum cytokine levels...
  29. ncbi Patient selection, cancer control, and complications after salvage local therapy for postradiation prostate-specific antigen failure: a systematic review of the literature
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 110:1417-28. 2007
    ..Based on a review of all series of post-RT salvage prostatectomy, cryosurgery, and brachytherapy published in English since 1990, morbidity can be substantial...
  30. ncbi Short-term cancer control after primary cryosurgical ablation for clinically localized prostate cancer using third-generation cryotechnology
    Thomas J Polascik
    Division of Urologic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Urology 70:117-21. 2007
    ..We report our initial experience using a transrectal ultrasound-guided, third-generation, argon/helium cryosurgical system...
  31. ncbi Comparison of systemic responses of radiofrequency ablation, cryotherapy, and surgical resection in a porcine liver model
    Kelvin K Ng
    Department of Surgery, Centre for the Study of Liver Disease, University of Hong Kong, Pokfulamad, Hong Kong, China com
    Ann Surg Oncol 11:650-7. 2004
    ..The degree of systemic response after hepatic radiofrequency ablation (RFA) has not been well investigated...
  32. ncbi Cosmetic results of cryosurgery versus surgical excision for primary uncomplicated basal cell carcinomas of the head and neck
    M R Thissen
    Departments of Dermatology and Clinical Epidemiology, University Hospital Maastricht, The Netherlands
    Dermatol Surg 26:759-64. 2000
    ..The incidence of multiple facial basal cell carcinomas (BCCs) is increasing...
  33. ncbi Cryosurgery for tumors
    Andrew A Gage
    Department of Surgery, State University of New York at Buffalo, Buffalo, NY, USA
    J Am Coll Surg 205:342-56. 2007
  34. ncbi Analysis of thermal stress in cryosurgery of kidneys
    Xiaoming He
    Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    J Biomech Eng 127:656-61. 2005
    In this study, the thermal stress distribution in cryosurgery of kidney was investigated using a multiphysics finite element model developed in ANSYS (V8.1)...
  35. pmc Experimental cryosurgery investigations in vivo
    A A Gage
    Department of Surgery, SUNY Buffalo, Buffalo, NY, USA
    Cryobiology 59:229-43. 2009
    b>Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue...
  36. ncbi Review of primary and salvage cryoablation for prostate cancer
    Joseph L Chin
    Division of Urological Surgery, University of Western Ontario, London, Canada N6A 4G5
    Cancer Control 14:231-7. 2007
    b>Cryosurgery has gained popularity as a minimally invasive treatment option for primary and recurrent prostate cancer...
  37. ncbi Cryoprobe biopsy increases the diagnostic yield in endobronchial tumor lesions
    Christian Schumann
    Center of Internal Medicine, Department of Internal Medicine II, University of Ulm, Ulm, Germany
    J Thorac Cardiovasc Surg 140:417-21. 2010
    ..The aim of this feasibility study was to prospectively evaluate the diagnostic yield and safety of cryobiopsy and forceps biopsy...
  38. ncbi Partial salvage cryoablation of the prostate for recurrent prostate cancer after radiotherapy failure
    Michael L Eisenberg
    Department of Urology, University of California San Francisco, San Francisco, California 94143 1695, USA
    Urology 72:1315-8. 2008
    ..To determine the efficacy of partial cryoablation of the prostate in the salvage setting...
  39. ncbi A randomized, double-blinded, placebo-controlled, multicenter, efficacy and safety study of 3.75% imiquimod cream following cryosurgery for the treatment of actinic keratoses
    Joseph L Jorizzo
    Department of Dermatology, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC, USA
    J Drugs Dermatol 9:1101-8. 2010
    Evaluate cryosurgery followed by 3.75% imiquimod cream to treat actinic keratoses (AK).
  40. ncbi Management of potentially malignant disorders: evidence and critique
    Giovanni Lodi
    Unita di Medicina e Patologia Orale, Dipartimento di Medicina Chirurgia e Odontoiatria, Universita degli Studi di Milano, Milano, Italia
    J Oral Pathol Med 37:63-9. 2008
    ....
  41. ncbi Enhancement of immunologic tumor regression by intratumoral administration of dendritic cells in combination with cryoablative tumor pretreatment and Bacillus Calmette-Guerin cell wall skeleton stimulation
    Masaru Udagawa
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Clin Cancer Res 12:7465-75. 2006
    ..We developed an effective immunotherapy, which could induce antitumor immune responses against shared and unique tumor antigens expressed in autologous tumors...
  42. ncbi Evidence-based review of the use of cryosurgery in treatment of basal cell carcinoma
    Agnieszka Kokoszka
    Department of Dermatology, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Dermatol Surg 29:566-71. 2003
    b>Cryosurgery has been used to treat basal cell carcinoma (BCC), and it has many technical advantages over other methods. It is therefore important to establish its efficacy as a treatment for BCC.
  43. ncbi Imiquimod enhances the systemic immunity attained by local cryosurgery destruction of melanoma lesions
    Pedro Redondo
    Department of Dermatology, University Clinic of Navarra, Pamplona, Navarra, Spain
    J Invest Dermatol 127:1673-80. 2007
    ..Local cryosurgery of B16/ovalbumin (OVA)-derived subcutaneous tumor nodules leads to curative destruction of the lesions...
  44. ncbi Pancreatic head cryosurgery: safety and efficiency in vivo--a pilot study
    Jialiang Li
    Guangzhou Fuda Cancer Hospital, Guangzhou, China
    Pancreas 41:1285-91. 2012
    Pancreatic cancer is the fourth leading cause of cancer-related death. Cryosurgery has emerged as a promising new technique for treatment...
  45. ncbi Five-year results of curettage-cryosurgery for 100 consecutive auricular non-melanoma skin cancers
    Peter Nordin
    Departments of Dermatology, Frölunda Specialist Hospital and Lundby Hospital, Gothenburg, Sweden
    J Laryngol Otol 116:893-8. 2002
    ..This five-year follow-up attempts to evaluate whether curettage-cryosurgery could be an alternative therapy for selected auricular NMSCs...
  46. pmc Percutaneous cryoablation of metastatic renal cell carcinoma for local tumor control: feasibility, outcomes, and estimated cost-effectiveness for palliation
    Hyun J Bang
    Department of Radiology, Wayne State University, Detroit, MI 48201, USA
    J Vasc Interv Radiol 23:770-7. 2012
    ..To assess complications, local tumor recurrences, overall survival (OS), and estimates of cost-effectiveness for multisite cryoablation (MCA) of oligometastatic renal cell carcinoma (RCC)...
  47. ncbi History of cryosurgery
    Lanja Ahmed
    Department of Urology, East Surrey Hospital, Redhill, Surrey, UK
    J Endourol 20:471-4. 2006
  48. ncbi An optimisation approach to multiprobe cryosurgery planning
    Giovanni Giorgi
    a Dipartimento di Matematica, Universita di Genova, Genova, Italy
    Comput Methods Biomech Biomed Engin 16:885-95. 2013
    In cryosurgery operations, tumoural cells are killed by means of a freezing procedure realised with the insertion of cryoprobes in the diseased tissue...
  49. ncbi Percutaneous cryoablation of small hepatocellular carcinoma with US guidance and CT monitoring: initial experience
    Antonio Orlacchio
    Department of Diagnostic Imaging and Interventional Radiology, University Hospital Tor Vergata, Via Oxford 81, 00199 Rome, Italy
    Cardiovasc Intervent Radiol 31:587-94. 2008
    ..Longer follow-up should provide proof of the effectiveness of this technique...
  50. ncbi Percutaneous cryoablation in combination with ethanol injection for unresectable hepatocellular carcinoma
    Ke Cheng Xu
    Fuda Cancer Hospital of Guangzhou, Guangzhou 510300, Guangdong Province, China
    World J Gastroenterol 9:2686-9. 2003
    ..To evaluate the effectiveness and safety of percutaneous hepatic cryoablation in combination with percutaneous ethanol injection (PEI) in patients with unresectable hepatocellular carcinoma (HCC)...
  51. ncbi Salvage cryosurgery of the prostate for failure after primary radiotherapy or cryosurgery: long-term clinical, functional, and oncologic outcomes in a large cohort at a tertiary referral centre
    Sven Wenske
    Department of Urology, Columbia University Medical Center, New York, NY, USA
    Eur Urol 64:1-7. 2013
    Salvage cryosurgery (SC) is a recognised option for patients who fail either primary radiation or cryosurgery.
  52. ncbi Ultrasonic biomicroscopic evaluation of cyclodialysis before and after direct cyclopexy
    Jeong Min Hwang
    Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
    Arch Ophthalmol 126:1222-5. 2008
    ..To investigate the clinical manifestations and surgical prognoses after direct cyclopexy in patients with traumatic cyclodialysis according to the cleft extent as determined by ultrasound biomicroscopy (UBM)...
  53. pmc Focal cryosurgical ablation of the prostate: a single institute's perspective
    Zachary Hale
    Section of Urologic Oncology, MD Anderson Cancer Center Orlando, 1400 S, Orange Ave, Orlando, FL 32806, USA
    BMC Urol 13:2. 2013
    ..Herein we evaluate the tolerability and non-oncologic outcomes of a highly select cohort of men that underwent focal cryoablation of the prostate for the treatment of localized prostate cancer...
  54. ncbi EASL and mRECIST responses are independent predictors of survival in hepatocellular carcinoma patients treated with cryoablation
    Huzi Li
    Department of Intervention Therapy, Tianjin Medical University Cancer Hospital and Institute, Tianjin, China
    Eur J Gastroenterol Hepatol 25:620-7. 2013
    ..The aim of this study was to determine which response evaluation criteria will best help predict the treatment efficacy of cryoablation for hepatocellular carcinoma...
  55. ncbi Long-term results of intralesional curettage and cryosurgery for treatment of low-grade chondrosarcoma
    Morteza Meftah
    Washington Cancer Institute, Washington Hospital Center, Georgetown University, 110 Irving Street N W, Room CI 2158, Washington, DC 20010, USA
    J Bone Joint Surg Am 95:1358-64. 2013
    ..The aim of this study was to assess the long-term oncologic and functional outcomes of two different cryosurgery techniques.
  56. ncbi Effect of blood flow and metabolism on multidimensional heat transfer during cryosurgery
    Gang Zhao
    Department of Thermal Science and Energy Engineering, University of Science and Technology of China, Hefei 230027, PR China
    Med Eng Phys 29:205-15. 2007
    b>Cryosurgery has been recently accepted as a treatment option for eradicating undesirable tissues, especially tumor tissues, due to its minimally invasive nature and low hospitalization needs...
  57. ncbi Effect of freezing parameters (freeze cycle and thaw process) on tissue destruction following renal cryoablation
    Matthew L Woolley
    Department of Urology, SUNY Stony Brook University Hospital and Medical Center, Stony Brook, NY 11794 8093, USA
    J Endourol 16:519-22. 2002
    ..The purpose of this study was to compare the effects of the number of freeze cycles (one v two) and the thaw process (active v passive) on renal tissue following cryodestruction...
  58. pmc Percutaneous cryosurgery for the treatment of hepatic colorectal metastases
    Ke Cheng Xu
    Cryosurgery Center for Cancer, Fuda Cancer Hospital Guangzhou, 167, West Xingang Rd, Guangzhou 510300, Guangdong Province, China
    World J Gastroenterol 14:1430-6. 2008
    To determine the safety and efficacy of efficacy of percutaneous cryosurgery for treatment of patients with hepatic colorectal metastases.
  59. ncbi Cryosurgery as primary treatment for localized prostate cancer
    Huibo Lian
    Department of Urology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Zhong Shan Road No 321, 210008 Nanjing, Jiangsu, China
    Int Urol Nephrol 43:1089-94. 2011
    ..To present the early results of the use of third-generation cryotherapy as primary treatment for localized prostate cancer in China...
  60. ncbi A model for the time dependent three-dimensional thermal distribution within iceballs surrounding multiple cryoprobes
    J C Rewcastle
    Departments of Oncology and Medical Physics, Tom Baker Cancer Centre, Calgary T2N 4N2, Canada
    Med Phys 28:1125-37. 2001
    ..Assuming a critical temperature of -40 degrees C, maximum ablative ratios of 0.21 and 0.3 for three and five probe configurations, respectively, were observed...
  61. ncbi An analytical study on the thermal effects of cryosurgery on selective cell destruction
    K J Chua
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576 Singapore
    J Biomech 40:100-16. 2007
    The aim of cryosurgery is to kill cells within a closely defined region maintained at a predetermined low temperature...
  62. pmc A pilot study on combination of cryosurgery and (125)iodine seed implantation for treatment of locally advanced pancreatic cancer
    Ke Cheng Xu
    Cryosurgery Center for Cancer, Fuda Cancer Hospital Guangzhou, No 167, West Xingang Road, Guangzhou 510300, Guangdong Province, China
    World J Gastroenterol 14:1603-11. 2008
    To study the therapeutic value of combination of cryosurgery and (125)iodine seed implantation for locally advanced pancreatic cancer.
  63. ncbi A prospective study of the use of cryosurgery for the treatment of actinic keratoses
    Keng Ee Thai
    Department of Medicine Dermatology, The University of Melbourne, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Int J Dermatol 43:687-92. 2004
    Actinic keratoses are the most common actinic lesions on Caucasian skin. Cryosurgery with liquid nitrogen is commonly used to treat actinic keratoses, but there have been few studies examining the true rate of cure in everyday ..
  64. ncbi Novel strategies for recurrent cardiac myxoma
    Kaushalendra Singh Rathore
    Department of Cardiothoracic Surgery, Royal Adelaide Hospital, Adelaide, Southern Australia, Australia
    Ann Thorac Surg 85:2125-6. 2008
    ..This time, however, endoscopically assisted techniques were used. The tumor was excised with supplementary cryoablation. The patient made a quick recovery from this second procedure and has had no recurrence after a 1-year follow-up...
  65. ncbi One-week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double-blind, vehicle-controlled, long-term study
    J Jorizzo
    Wake Forest School of Medicine, Winston Salem, NC 27157 1071, USA
    J Drugs Dermatol 5:133-9. 2006
    ..is currently approved for the treatment of actinic keratosis (AK) and is often used prior to or following cryosurgery as interval therapy in patients with severe AK lesions...
  66. ncbi Cryosurgery: ultrastructural changes in pancreas tissue after low temperature exposure
    N N Korpan
    Vienna International Institute for Cryosurgery, Department of Surgery, Rudolfinerhaus, Billrothstrasse 78, A 1190 Vienna, Austria
    Technol Cancer Res Treat 6:59-67. 2007
    ..It is now evident that the thermal parameters used in the past for freezing during cryosurgery were not precise; this may have resulted in the failure of treatment...
  67. ncbi Pain evaluation in the cryosurgery of actinic keratoses
    Claudia Schermann Poziomczyk
    Hospital Sao Lucas, PUC RS, Brazil
    An Bras Dermatol 86:645-50. 2011
    ..b>Cryosurgery with liquid nitrogen is the most common method for treating the lesions.
  68. ncbi The efficacy evaluation of cryosurgery in pancreatic cancer patients with the expression of CD44v6, integrin-β1, CA199, and CEA
    Gang Zhou
    Department of Oncology, The GIBH Affiliated Fuda Hospital, Chinese Academy of Sciences, Chigang, Guangzhou 510305, China
    Mol Biotechnol 52:59-67. 2012
    ..05). The levels of CD44v6, integrin-β1, CA199, and CEA expression in the patients prior cryosurgery and chemotherapy were significantly higher than those in the control group (P < 0...
  69. ncbi Focal therapy for clinically localized prostate cancer
    Pablo Marchetti
    Section of Urology, University of Chicago Medical Center, Illinois, USA
    Arch Esp Urol 64:815-22. 2011
    ..Clinical trials are ongoing to provide data on the feasibility and reliability of these new therapies, the capability of eradicating cancers, rates of secondary treatment, and impact on urinary and sexual function...
  70. ncbi [Clinical study of cryoablation in the salvage treatment of stage III non-small cell lung cancer]
    Yong Li
    Department of Interventional Therapeutics, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
    Zhonghua Yi Xue Za Zhi 91:2205-7. 2011
    ..To evaluate the efficacy and safety of argon-helium cryoablation as a salvage therapy for the failure cases of non-small cell lung cancer (NSCLC) after radiochemotherapy...
  71. ncbi Outcome of MR-guided percutaneous cryoablation for hepatocellular carcinoma
    Tadashi Shimizu
    Department of Biomedical Science and Engineering, Faculty of Health Sciences, Hokkaido University, North 12 West 5, Kita ku, Sapporo, 060 0812, Japan
    J Hepatobiliary Pancreat Surg 16:816-23. 2009
    ..To assess the mid-term results of MR-guided percutaneous cryoablation for small hepatocellular carcinoma (HCC)...
  72. doi Technologies for ablation of hepatocellular carcinoma
    Matthew R Callstrom
    Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, USA
    Gastroenterology 134:1831-5. 2008
  73. ncbi Percutaneous tumor ablation: microencapsulated echo-guided interstitial chemotherapy combined with cryosurgery increases necrosis in prostate cancer
    P J Le Pivert
    NuVueTherapeutics, VA 22030, USA
    Technol Cancer Res Treat 8:207-16. 2009
    ..cells and retard tumor growth in the region surrounding the IB where tumor cells escape the lethal effects of cryosurgery. The study suggests that cryochemotherapy may become a more predictable technique that could be indicated as an ..
  74. ncbi Cryosurgery for treatment of subcutaneously xenotransplanted tumors in rats and its effect on cellular immunity
    J G Liu
    The First People s Hospital of JiuJiang, Jiujiang 332000, Jiangxi Province, China
    Technol Cancer Res Treat 10:339-46. 2011
    b>Cryosurgery has shown encouraging therapeutic effects on some solid tumors but its effect on the cellular immunity remains unclear...
  75. ncbi Aneurysmal bone cyst: the role of cryosurgery as local adjuvant treatment
    S P Peeters
    Department of Orthopaedic Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Surg Oncol 100:719-24. 2009
    ..There is debate on whether or not to use adjuvant therapy to decrease the local recurrence rate. This study is done to assess the outcome of curettage and cryosurgery as a treatment of ABC.
  76. ncbi Decrease in size of non-treated lesions after cryoablation for hepatocellular carcinoma
    Lin Zhou
    Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing, China
    Hepatogastroenterology 59:252-4. 2012
    ..6%, respectively. Following the cryoablations they dropped to 436ng/mL and 7.6%, respectively, 10 months later. The patient remains in good condition until now...
  77. ncbi Pain control requirements for percutaneous ablation of renal tumors: cryoablation versus radiofrequency ablation--initial observations
    Mohamad E Allaf
    Brady Urological Institute, Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Radiology 237:366-70. 2005
    ....
  78. ncbi A comparison between cryosurgery and conventional stripping in varicose vein surgery: perioperative features and complications
    Ruben Schouten
    Department of General Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Ann Vasc Surg 20:306-11. 2006
    b>Cryosurgery is a relatively new treatment option for vein stripping in case of insufficiency of the great saphenous vein (GSV)...
  79. ncbi Hepatic hemorrhage caused by percutaneous tumor ablation: radiofrequency ablation versus cryoablation in a porcine model
    Sarah A Shock
    Department of Radiology, University of Wisconsin Hospital and Clinics, 600 Highland Ave, Madison, WI 53792 3252, USA
    Radiology 236:125-31. 2005
    ..To determine the extent of hepatic hemorrhage caused by percutaneous cryoablation performed with a small-diameter cryoablation probe compared with that caused by percutaneous radiofrequency (RF) ablation in a porcine model...
  80. ncbi A comparative study of focal medium-depth chemical peel versus cryosurgery for the treatment of solar lentigo
    Engin Sezer
    Department of Dermatology, Gaziosmanpasa University School of Medicine, Tokat 60100, Turkey
    Eur J Dermatol 17:26-9. 2007
    ..to compare the efficacy of a focal medium-depth chemical peel regimen using 70% glycolic acid and 35% TCA with cryosurgery, in the treatment of solar lentigines of the hands...
  81. ncbi Ultrasound-guided percutaneous cryotherapy of hepatocellular carcinoma
    H W Chen
    Department of Hepatobiliary Surgery, The First People s Hospital of Foshan, Foshan, 528000 Guang Dong, People s Republic of China
    Int J Surg 9:188-91. 2011
    ..This study aimed to determine the safety and efficacy of percutaneous cryotherapy for unresectable or recurrent hepatocellular carcinoma (HCC)...
  82. ncbi Cryoablation with an 8-mm tip catheter for pediatric atrioventricular nodal reentrant tachycardia is safe and efficacious with a low incidence of recurrence
    Eric S Silver
    Division of Pediatric Cardiology, Morgan Stanley Children s Hospital of New York Presbyterian Hospital, Columbia University, New York, New York 10032, USA
    Pacing Clin Electrophysiol 33:681-6. 2010
    ..Limited information is available regarding efficacy, mid-term outcomes, and complications related to the use of the 8-mm Freezor Max Cryoablation catheter (Medtronic, Minneapolis, MN, USA) in pediatric patients...
  83. ncbi BioGlue iceball stabilization to minimize the risk of hemorrhage during laparoscopic renal cryoablation
    Adam C Mues
    Department of Urology, University of California, Irvine, California, USA
    Urology 78:353-6. 2011
    ..To evaluate the application of a BioGlue adhesive shell to minimize iceball fracture. Iceball fracture and hemorrhage is common with laparoscopic cryoablation (LCA) of larger (>4 cm) renal tumors...
  84. ncbi Enhanced renal cryoablation with hilar clamping and intrarenal cooling in a porcine model
    William Collyer
    Division of Urology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Urology 63:1209-12. 2004
    ..To evaluate the effects of renal vascular control and intrarenal cooling on the size of renal lesions attainable with a 3.4-mm cryoprobe...
  85. pmc Cryoablation for atrioventricular nodal reentrant tachycardia in young patients: predictors of recurrence
    Nikhil K Chanani
    Department of Pediatrics, Division of Cardiology, University of California, San Francisco, California, USA
    Pacing Clin Electrophysiol 31:1152-9. 2008
    ..Our objective was to evaluate the clinical outcomes of cryoablation for AVNRT with the 4-mm and 6-mm tip cryoablation catheters in a young population and to elicit predictors of arrhythmia recurrence...
  86. ncbi Cryoablation of typical atrioventricular nodal reentrant tachycardia in children: six years' experience and follow-up in a single center
    Fabrizio Drago
    Pediatric Cardiology Department, Bambino Gesu Hospital, Rome, Italy
    Pacing Clin Electrophysiol 33:475-81. 2010
    ..We retrospectively reviewed consecutive cryoablation procedures for the treatment of atrioventricular nodal reentrant tachycardia (AVNRT) in children and young adults in a single pediatric center...
  87. ncbi 'Time to effect' during cryomapping: a parameter related to the long-term success of accessory pathways cryoablation in children
    Fabrizio Drago
    Paediatric Cardiology Department, Bambino Gesu Hospital, Piazza Sant Onofrio 4, 00165 Rome, Italy
    Europace 11:630-4. 2009
    ..Cryoablation is an effective treatment for children with an accessory pathway (AP). Nevertheless, AP may recur after a successful procedure. The aim of this study was to identify the factors predictive of AP recurrence...
  88. ncbi The extent of cryosurgery increases the complication rate after hepatic cryoablation
    Richard L Sohn
    Department of Surgery, Wayne State University, Harper University Hospital, Detroit, Michigan 48201, USA
    Am Surg 69:317-22; discussion 322-3. 2003
    Although there have been many reports on the use of cryosurgery to ablate hepatic malignancies none have specifically examined the relationship of complication rates to the extent of cryoablation...
  89. ncbi Assessment of the efficacy of cryosurgery in the treatment of granuloma faciale
    A Panagiotopoulos
    Department of Cryosurgery, A Sygros Hospital, 5I Dragoumi Str, 16121, Athens, Greece
    Br J Dermatol 154:357-60. 2006
    Granuloma faciale (GF) is an uncommon dermatosis of unknown pathogenesis. Multiple treatments have been proposed with varying results. We report nine cases treated successfully with cryosurgery and we review the literature.
  90. ncbi Long-term outcomes for cryoablation of pediatric patients with atrioventricular nodal reentrant tachycardia
    Martin J LaPage
    Medical University of South Carolina, Charleston, SC, USA
    Am J Cardiol 105:1118-21. 2010
    ..In conclusion, cryoablation is a safe and effective therapy for AVNRT. Recurrences can develop late, up to 2 years after initially successful ablation...
  91. ncbi Effects of inadvertent atrioventricular block on clinical outcomes during cryoablation of the slow pathway in the treatment of atrioventricular nodal re-entrant tachycardia
    Antonio De Sisti
    Rhythmology Department, Cardiology Institute, Pitie Salpetriere Hospital, Paris, France
    Europace 10:1421-7. 2008
    ..The study aimed at evaluating the long-term effects of transient atrioventricular (AV) block on clinical outcomes during atrioventricular nodal re-entrant tachycardia (AVNRT) cryoablation...
  92. pmc Sequential use of transarterial chemoembolization and percutaneous cryosurgery for hepatocellular carcinoma
    Ke Cheng Xu
    Cryosurgery Center for Cancer, Fuda Cancer Hospital, Guangzhou, Guangdong Province, China
    World J Gastroenterol 15:3664-9. 2009
    To evaluate the efficacy of sequential use of transarterial chemoembolization (TACE) and percutaneous cryosurgery for unresectable hepatocellular carcinoma (HCC).
  93. ncbi Intralesional cryosurgery using lumbar puncture and/or hypodermic needles for large, bulky, recalcitrant keloids
    S Gupta
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Dermatol 40:349-53. 2001
    ..A variety of treatment modalities are currently in use, indicating that none is totally satisfactory. Surface cryosurgery is effective for smaller keloids, but not for larger ones...
  94. ncbi Time course of esophageal lesions after catheter ablation with cryothermal and radiofrequency ablation: implication for atrio-esophageal fistula formation after catheter ablation for atrial fibrillation
    Kenneth Lauren Ripley
    CryoCor Inc, San Diego, California, USA
    J Cardiovasc Electrophysiol 18:642-6. 2007
    ..Atrio-esophageal fistulas have been described as a consequence of radiofrequency (RF) ablation for the treatment of atrial fibrillation (AF). However, whether cryoablation can avoid this potential fatal complication remains unclear...
  95. ncbi Cryothermal slow pathway modification for atrioventricular nodal reentrant tachycardia
    Paul Khairy
    Electrophysiology Service, Montreal Heart Institute, 5000 Belanger St East, Montreal, Quebec, Canada H1T 1C8
    Europace 9:909-14. 2007
    ..persistent dual atrioventricular (AV) nodal physiology with or without echo beats...
  96. ncbi Correlations between long-term results after cryoablation for atrioventricular nodal reentry tachycardia and a residual jump associated or not with a single echo
    Antonio De Sisti
    Rhythmology Unit, Cardiology Institute, Pitie Salpetriere Hospital, Paris, France
    Europace 14:261-6. 2012
    ..The purpose of this study was to evaluate if a residual jump associated or not with an isolated echo is correlated with outcome...
  97. ncbi Retrospective comparison of 25-gauge transconjunctival sutureless vitrectomy to 20-gauge vitrectomy for the repair of pseudophakic primary inferior rhegmatogenous retinal detachment
    Marcus H Colyer
    The Retina Group of Washington, Fairfax, Virginia 22031, USA
    Retina 30:1678-84. 2010
    ..To compare anatomical and functional outcomes of 25-gauge transconjunctival sutureless pars plana vitrectomy (PPV) to standard 20-gauge 3-port PPV for the treatment of pseudophakic rhegmatogenous retinal detachments with inferior breaks...
  98. pmc Tumour seeding after percutaneous cryoablation for hepatocellular carcinoma
    Chun Ping Wang
    Center of Therapeutic Research for Hepatocellular Carcinoma, 302 Hospital of PLA, Beijing 100039, China
    World J Gastroenterol 18:6587-96. 2012
    ..To assess the rate and risk factors for tumour seeding in a large cohort of patients...
  99. pmc Long-term follow-up after catheter ablation for atrioventricular nodal reentrant tachycardia: a comparison of cryothermal and radiofrequency energy in a large series of patients
    Bruno Schwagten
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    J Interv Card Electrophysiol 30:55-61. 2011
    ..Cryoablation (cryo) has the potential to assess the safety of a site before the energy is applied...
  100. ncbi [New method for the treatment of atrial fibrillation: circumferential cryoballoon ablation of the pulmonary vein]
    Csaba Foldesi
    Gottsegen György Országos Kardiológiai Intézet Budapest Haller u 29 1096
    Orv Hetil 149:1779-84. 2008
    ..On this occasion we review the potential advantages of this technique which may serve as basis for its widespread use in the future...
  101. pmc Outcomes of ultrasound-guided percutaneous argon-helium cryoablation of hepatocellular carcinoma
    Yongping Yang
    Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302nd Hospital, Beijing, 100039, China
    J Hepatobiliary Pancreat Sci 19:674-84. 2012
    ..To evaluate the efficacy and safety of ultrasound (US)-guided percutaneous argon-helium cryoablation for hepatocellular carcinoma (HCC) and determine appropriate indications...

Research Grants47

  1. Micro-machined Joule-Thomson Cryosurgical Instrument
    YOGESH GIANCHANDANI; Fiscal Year: 2007
    ..here will enable MEMS technology, with all of its inherent advantages, to be brought to bear on the problem of cryosurgery. The cryoprobe wilJbe fabricated using conventional micro-fabrication techniques resulting in a low cost device ..
  2. A Novel Approach to Nerve-Sparing Prostate Cryosurgery
    KRISTI SNYDER; Fiscal Year: 2007
    ..to potentiate cell death in cancer cells during ablative freezing processes - a regime that couples traditional cryosurgery with adjuvant (e.g. 5-FU, cisplatin) treatments...
  3. Treg-Th17 Axis Modulation and Induction of Tumor Immunity with Cryosurgery
    JESSE JAMES VEENSTRA; Fiscal Year: 2013
    ..Alternatively, cryosurgery, the use of freezing temperatures to destroy diseased tissue, is increasingly recognized as an efficient, ..
  4. Developing a Computerized Training Tool for Cryosurgery
    Yoed Rabin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cryosurgery is the destruction of undesired tissues by freezing...
  5. MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESS
    Dan Stoianovici; Fiscal Year: 2001
    ..is an accurate mechanism for performing precise image-guided procedures such as biopsy, brachytherapy, cryosurgery, hyperthermia, interstitial laser therapy, focused ultrasound and microwaves, chemotherapy, gene therapy, or ..
  6. MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESS
    Dan Stoianovici; Fiscal Year: 2004
    ..is an accurate mechanism for performing precise image-guided procedures such as biopsy, brachytherapy, cryosurgery, hyperthermia, interstitial laser therapy, focused ultrasound and microwaves, chemotherapy, gene therapy, or ..
  7. Personal Patient Profile-Prostate: Testing and Implementation in Health Networks
    Donna L Berry; Fiscal Year: 2013
    ..LPC can be treated with one or more modalities including observation alone, surgery, cryosurgery, hormonal therapy, brachytherapy, or external beam radiation therapy...
  8. A Resorbable Cryoprobe Provides a Salvage Therapeutic Option
    KRISTI SNYDER; Fiscal Year: 2007
    ..to potentiate cell death in cancer cells during ablative freezing processes - a regime that couples traditional cryosurgery with adjuvant (e.g. 5-FU, cisplatin) treatments...
  9. ELECTRONIC CRYOGENIC SURGICAL PROBE
    ARCHIE HAMILTON; Fiscal Year: 1991
    b>Cryosurgery is commonly used in the practice of dermatology to treat various benign and malignant neoplasms and lesions of the skin...
  10. Cryosurgery with Electrical Impedance Tomography
    Alexander Hartov; Fiscal Year: 2001
    b>Cryosurgery consists of deep-freezing tissue in situ to destroy, manipulate or change its structure...
  11. ELECTRICAL IMPEDANCE TOMOGRAPHY IMAGED CRYOSURGERY
    Boris Rubinsky; Fiscal Year: 2003
    ..The objective of this proposal is to develop the technique of Electrical Impedance Tomography (EIT) imaged cryosurgery. An E1T image is acquired by: a) injecting small, sinusoidal electrical currents into the body, b) measuring ..
  12. NURSING SUPPORT OF DECISIONS BY MEN WITH PROSTATE CANCER
    Donna Berry; Fiscal Year: 2002
    ..cancer (LPC) can be treated with one or more of several modalities including observation alone, surgery, cryosurgery, hormonal therapy, brachytherapy, or external beam radiation therapy...
  13. Techniques for MRI-Guided Cryosurgery of Prostate Cancer
    Bruce Daniel; Fiscal Year: 2006
    ..We believe advances in MRI guidance will enable minimally invasive, super-selective, targeted cryosurgery as an outpatient treatment for localized disease with minimal risk and morbidity...
  14. METABOLIC STUDIES OF RESPONSE TO PROSTATE CANCER THERAPY
    John Kurhanewicz; Fiscal Year: 2000
    ..In preliminary studies we have also observed changes in prostatic citrate and choline levels after cryosurgery that have correlated with clinical markers of therapeutic response...
  15. INTERACTIVE IMAGE GUIDED THERMAL THERAPY FOR LOCALIZED P
    Roger McNichols; Fiscal Year: 2001
    ..They include brachytherapy, hyperthermia, laser therapy, focused ultrasound, focused microwave, and cryosurgery. These local treatments could offer significant advantages over current standards of treatment such as radical ..
  16. Shape Control of Freeze Zones in Prostate Cryosurgery
    James Barry; Fiscal Year: 2002
    ..Our commercialization strategy is based on licensing the technology developed under this program to an existing vendor of medical equipment. ..
  17. IMPROVING CRYOSURGERY THROUGH UNDERSTANDING APOPTOSIS
    Robert Van Buskirk; Fiscal Year: 2000
    ..proposed commercial application: not available..
  18. Transient Thermal Modeling and Simulation Environment
    NABIL ELKOUH; Fiscal Year: 2003
    ..applications involve the use of energy deposition into in homogeneous structures, such as laser surgery, cryosurgery, and RF ablation. In many cases, numerous advantages can be realized when the energy source is pulsed...
  19. Micro-machined Joule-Thomson Cryosurgical Instrument
    YOGESH GIANCHANDANI; Fiscal Year: 2004
    ..here will enable MEMS technology, with all of its inherent advantages, to be brought to bear on the problem of cryosurgery. The cryoprobe wilJbe fabricated using conventional micro-fabrication techniques resulting in a low cost device ..
  20. ESTABLISHMENT 0F MECHANISMS OF CRYODESTRUCTION
    John Bischof; Fiscal Year: 2002
    ..There is debate as to the optimal treatment of the disease of which cryosurgery is one...
  21. CRYOPROBES FOR ULTRASONICALLY GUIDED CANCER TREATMENT
    John Baust; Fiscal Year: 1992
    We propose to develop a series of products to perform percutaneous cryosurgery on cancers of the prostate, liver, brain and pancreas...
  22. Thermo mechanical stress in cryopreserved blood vessels
    Yoed Rabin; Fiscal Year: 2006
    ..Although the experimental work in this study is targeted to blood vessels, the results of this study could be expanded and become useful for a wide variety of cryopreserved natural tissues and engineered constructs. ..
  23. Developing computerized tools for cryosurgery planning
    Yoed Rabin; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): [unreadable] Cryosurgery has been known as an invasive surgical technique since 1961, when Cooper and Lee invented the first cryoprobe...
  24. Neoadjuvant Cytokine Immunotherapy by PLA Microspheres
    Michael Sabel; Fiscal Year: 2007
    ..interested in the anti-tumor immunity generated by in situ tumor destruction when I investigated the use of cryosurgery in the treatment of breast cancer...
  25. STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLs
    Stephen Nakada; Fiscal Year: 2005
    ..abstract_text> ..
  26. OCULAR MELANOMA
    David Wilson; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  27. Dermatomyositis Skin Disease Severity Measure Validation
    JOSPEH JORIZZO; Fiscal Year: 2003
    ..abstract_text> ..
  28. VIBRO-ACOUSTOGRAPHY SYSTEM WITH CONTACT ARRAY PROBE
    Mostafa Fatemi; Fiscal Year: 2005
    ....
  29. Early Detection and Prognosis of Patients with Hepatocellular Carcinoma
    Jorge Marrero; Fiscal Year: 2008
    ..Therefore, identifying the risk factors, identifying new methods for early detection and determining prognosis for this tumor is of extreme importance. [unreadable] [unreadable]..
  30. Complications of Cirrhosis in American Patients
    Jorge Marrero; Fiscal Year: 2008
    ..I will supervise the conduct of the proposed research and meet with my mentors and advisors regularly. Completing this proposal will allow me to achieve my career goal and to contribute to an improve outcome of patients with HCC. ..
  31. TAMOXIFEN & BREAST CANCER--ACCEPTANCE/COST EFFECTIVENESS
    Joy Melnikow; Fiscal Year: 2002
    ..abstract_text> ..
  32. Antiproliferative Rx for venous neointimal hyperplasia
    Prabir Roy Chaudhury; Fiscal Year: 2005
    ..We believe that the results from this study could transform the clinical care of hemodialysis patients and at the same time result in the successful clinical application of local therapy for the treatment of neointimal hyperplasia...
  33. Improved Cryosurgical Destruction of Prostate Cancer
    John Bischof; Fiscal Year: 2009
    ..The use of cryosurgery to treat prostate cancer is growing as evidenced by the inclusion of a chapter on its use in Campbell's ..
  34. THERAPY OF HEPATIC METASTASES FROM COLORECTAL CARCINOMA
    Nancy Kemeny; Fiscal Year: 2001
    ..Fong's project, PET scans will be obtained before and after cryosurgery to document residual disease and response); and (3) to test new drugs such as AG337 (a thymidylate synthase ..
  35. Improving cancer sample preservation through analyzing cell stress pathways
    J Baust; Fiscal Year: 2007
    ..As a result, archival storage of cancer tissues will be improved and poorly preserved specimens can be rescued. [unreadable] [unreadable] [unreadable]..
  36. CRYO-ROP HEADQUARTERS--PHASE IV
    EARL PALMER; Fiscal Year: 2002
    ..An incidence comparison will be made between treated and untreated eyes for many sequelae and complications, such as late retinal detachment, macular degeneration, and vision failure. ..
  37. Cultured Human Cell Monolayers Cryopreserved In Situ
    J Baust; Fiscal Year: 2005
    ..e. 384 well plates, one year storage time at -80C). CPSI plans to license the developed technology to both small biotechnology companies and large pharmaceutical industries in Phase III. ..
  38. ANTI-GANGLIOSIDE IgM IN DIAGNOSING PROSTATE CANCER
    Mepur Ravindranath; Fiscal Year: 2006
    ..An active collaboration with Pacific Urology Institute is ongoing and will continue to be a participant in this study. ..
  39. Novel MRI Contrast Agent for Monitoring Thermal Ablation
    Nathan Mcdannold; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  40. Anti-GM1b IgM for Detection of Localized Prostate Cancer
    Mepur Ravindranath; Fiscal Year: 2005
    ....
  41. Pulsed Electron Avalanche Knife: Intraocular Microsurg.
    Daniel Palanker; Fiscal Year: 2006
    ..The low cost and small size of this system combined with high precision, reliability and versatility should allow for a widespread acceptance into operating practice. ..
  42. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  43. Surveillance Strategies Following Treatment for CIN
    Joy Melnikow; Fiscal Year: 2007
    ..Alternative strategies for post-treatment surveillance will be evaluated. [unreadable] [unreadable] [unreadable]..
  44. Anti/Proapoptotic ratio and cell preservation efficacy
    J Baust; Fiscal Year: 2002
    ..abstract_text> ..
  45. Development of an In Situ Anhydrobiotic Tissue Culture Process
    J Baust; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..