coronary artery bypass

Summary

Summary: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.

Top Publications

  1. ncbi Remote ischemic preconditioning in human coronary artery bypass surgery: from promise to disappointment?
    Ishtiaq A Rahman
    Department of Cardiothoracic Surgery, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, UK
    Circulation 122:S53-9. 2010
  2. ncbi Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial
    Matthias Thielmann
    Department of Thoracic and Cardiovascular Surgery, Universitatsklinikum Essen, Essen, Germany
    Lancet 382:597-604. 2013
  3. ncbi Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease
    Patrick W Serruys
    Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    N Engl J Med 360:961-72. 2009
  4. pmc Coronary revascularization trends in the United States, 2001-2008
    Andrew J Epstein
    Department of Veterans Affairs Center for Health Equity Research and Promotion, Philadelphia, Pennsylvania, USA
    JAMA 305:1769-76. 2011
  5. ncbi Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial
    Derek J Hausenloy
    The Hatter Cardiovascular Institute, University College London Hospital, London, UK
    Lancet 370:575-9. 2007
  6. ncbi Strategies for multivessel revascularization in patients with diabetes
    Michael E Farkouh
    Mount Sinai School of Medicine, New York, NY 10029, USA
    N Engl J Med 367:2375-84. 2012
  7. ncbi N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial
    Leonardo Calo
    Department of Cardiac Diseases, San Filippo Neri Hospital, Rome, Italy
    J Am Coll Cardiol 45:1723-8. 2005
  8. ncbi Transfusion in coronary artery bypass grafting is associated with reduced long-term survival
    Colleen Gorman Koch
    Department of Cardiothoracic Anesthesia, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 81:1650-7. 2006
  9. ncbi Omega-3 fatty acid supplementation does not reduce risk of atrial fibrillation after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial
    Palaniappan Saravanan
    University of Manchester, Manchester, United Kingdom
    Circ Arrhythm Electrophysiol 3:46-53. 2010
  10. ncbi Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery
    Jose A Suaya
    Schneider Institutes for Health Policy, Heller School MS 035, Brandeis University, Waltham, MA 02454 9110, USA
    Circulation 116:1653-62. 2007

Detail Information

Publications295 found, 100 shown here

  1. ncbi Remote ischemic preconditioning in human coronary artery bypass surgery: from promise to disappointment?
    Ishtiaq A Rahman
    Department of Cardiothoracic Surgery, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, UK
    Circulation 122:S53-9. 2010
    ..We assessed whether remote ischemic preconditioning (RIPC) improves myocardial, renal, and lung protection after on-pump coronary surgery...
  2. ncbi Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial
    Matthias Thielmann
    Department of Thoracic and Cardiovascular Surgery, Universitatsklinikum Essen, Essen, Germany
    Lancet 382:597-604. 2013
    Remote ischaemic preconditioning has been associated with reduced risk of myocardial injury after coronary artery bypass graft (CABG) surgery. We investigated the safety and efficacy of this procedure.
  3. ncbi Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease
    Patrick W Serruys
    Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    N Engl J Med 360:961-72. 2009
    ..Our trial compared PCI and CABG for treating patients with previously untreated three-vessel or left main coronary artery disease (or both)...
  4. pmc Coronary revascularization trends in the United States, 2001-2008
    Andrew J Epstein
    Department of Veterans Affairs Center for Health Equity Research and Promotion, Philadelphia, Pennsylvania, USA
    JAMA 305:1769-76. 2011
    ..It is uncertain how new revascularization technologies, new clinical evidence from trials, and updated clinical guidelines have influenced the volume and distribution of coronary revascularizations over the past decade...
  5. ncbi Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial
    Derek J Hausenloy
    The Hatter Cardiovascular Institute, University College London Hospital, London, UK
    Lancet 370:575-9. 2007
    ..organ protects remote organs from a sustained episode of ischaemia, is beneficial for patients undergoing coronary artery bypass graft surgery is unknown...
  6. ncbi Strategies for multivessel revascularization in patients with diabetes
    Michael E Farkouh
    Mount Sinai School of Medicine, New York, NY 10029, USA
    N Engl J Med 367:2375-84. 2012
    ..We sought to discover whether aggressive medical therapy and the use of drug-eluting stents could alter the revascularization approach for patients with diabetes and multivessel coronary artery disease...
  7. ncbi N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial
    Leonardo Calo
    Department of Cardiac Diseases, San Filippo Neri Hospital, Rome, Italy
    J Am Coll Cardiol 45:1723-8. 2005
    ..of this study was to assess the efficacy of preoperative and postoperative treatment with n-3 polyunsaturated fatty acids (PUFAs) in preventing the occurrence of atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG).
  8. ncbi Transfusion in coronary artery bypass grafting is associated with reduced long-term survival
    Colleen Gorman Koch
    Department of Cardiothoracic Anesthesia, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 81:1650-7. 2006
    ..we examined the influence of PRBC transfusion and component therapy on long-term survival after isolated coronary artery bypass grafting after controlling for the effect of demographics, comorbidities, operative factors, and the early ..
  9. ncbi Omega-3 fatty acid supplementation does not reduce risk of atrial fibrillation after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial
    Palaniappan Saravanan
    University of Manchester, Manchester, United Kingdom
    Circ Arrhythm Electrophysiol 3:46-53. 2010
    ..Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been reported to reduce the risk of sudden cardiac death presumed to be due to fatal ventricular arrhythmias, but their effect on atrial arrhythmias is unclear...
  10. ncbi Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery
    Jose A Suaya
    Schneider Institutes for Health Policy, Heller School MS 035, Brandeis University, Waltham, MA 02454 9110, USA
    Circulation 116:1653-62. 2007
    ..Cardiac rehabilitation (CR) is effective in prolonging survival and reducing disability in patients with coronary heart disease. However, national use patterns and predictors of CR use have not been evaluated thoroughly...
  11. ncbi Off-pump or on-pump coronary-artery bypass grafting at 30 days
    Andre Lamy
    Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada
    N Engl J Med 366:1489-97. 2012
    ..The relative benefits and risks of performing coronary-artery bypass grafting (CABG) with a beating-heart technique (off-pump CABG), as compared with cardiopulmonary bypass (on-pump CABG), are not clearly established...
  12. ncbi Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial
    E Kottenberg
    Klinik für Anästhesiologie und Intensivmedizin, Universitat Duisburg Essen, Universitatsklinikum Essen, Germany
    Acta Anaesthesiol Scand 56:30-8. 2012
    ..Specifically, we hypothesized that RIPC during isoflurane anesthesia attenuates myocardial injury in patients undergoing coronary artery bypass graft (CABG) surgery, and that effects may be different during propofol anesthesia.
  13. ncbi Impact of preoperative anemia on outcome in patients undergoing coronary artery bypass graft surgery
    Alexander Kulier
    Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austri
    Circulation 116:471-9. 2007
    ..Thus, we determined the effects of low preoperative hemoglobin and comorbidities on postoperative adverse outcomes in patients with coronary artery bypass graft in a large comprehensive multicenter study.
  14. ncbi Remote ischemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrest
    Matthias Thielmann
    Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Germany
    Basic Res Cardiol 105:657-64. 2010
    ..RIPC) with transient upper limb ischemia reduces myocardial injury in patients undergoing on-pump coronary artery bypass grafting (CABG) with cross-clamp fibrillation or blood cardioplegia for myocardial protection...
  15. ncbi Improved survival with radial artery versus vein conduits in coronary bypass surgery with left internal thoracic artery to left anterior descending artery grafting
    Anoar Zacharias
    Division of Cardiovascular Surgery, St Vincent Mercy Medical Center, Toledo, Ohio 43608, USA
    Circulation 109:1489-96. 2004
    ..This grafting also led to increased use of other arterial conduits, of which the radial artery is most popular. Whether radial grafting improves survival beyond that achieved by LITA-LAD alone is not known...
  16. ncbi A comparison of on-pump and off-pump coronary bypass surgery in low-risk patients
    Hendrik M Nathoe
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    N Engl J Med 348:394-402. 2003
    ....
  17. ncbi Effect of remote ischemic preconditioning on clinical outcomes in patients undergoing coronary artery bypass graft surgery (ERICCA): rationale and study design of a multi-centre randomized double-blinded controlled clinical trial
    Derek J Hausenloy
    The Hatter Cardiovascular Institute, University College London, London, UK
    Clin Res Cardiol 101:339-48. 2012
    ..Novel cardioprotective strategies are required to improve clinical outcomes in high risk patients undergoing coronary artery bypass graft (CABG) ± valve surgery...
  18. pmc Reappraisal of a 20-year experience with the radial artery as a conduit for coronary bypass grafting
    Paul Achouh
    Department of Cardiovascular Surgery, Hôpital Georges Pompidou, Paris, France
    Eur J Cardiothorac Surg 41:87-92. 2012
    ..This study aimed at evaluating the clinical and angiographic results of the radial artery (RA) used as a coronary bypass graft over 20 years...
  19. ncbi The impact of deep sternal wound infection on long-term survival after coronary artery bypass grafting
    Ioannis K Toumpoulis
    St Luke s Roosevelt Hospital Center at Columbia University, 45 East Eighty Ninth St, New York, NY 10128, USA
    Chest 127:464-71. 2005
    To identify the impact of deep sternal wound infection (DSWI) on long-term survival after coronary artery bypass grafting (CABG).
  20. ncbi An alternative scoring system to predict risk for surgical site infection complicating coronary artery bypass graft surgery
    N Deborah Friedman
    Victorian Hospital Acquired Infection Surveillance System, Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 28:1162-8. 2007
    To analyze the risk factors for surgical site infection (SSI) complicating coronary artery bypass graft (CABG) surgery and to create an alternative SSI risk score based on the results of multivariate analysis.
  21. ncbi Presurgical depression predicts medical morbidity 6 months after coronary artery bypass graft surgery
    Matthew M Burg
    VA Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    Psychosom Med 65:111-8. 2003
    ..to poor medical prognosis in patients with coronary artery disease and to diminished quality of life after coronary artery bypass graft surgery (CABG)...
  22. ncbi Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial
    Friedrich W Mohr
    Herzzentrum Universität Leipzig, Leipzig, Germany
    Lancet 381:629-38. 2013
    We report the 5-year results of the SYNTAX trial, which compared coronary artery bypass graft surgery (CABG) with percutaneous coronary intervention (PCI) for the treatment of patients with left main coronary disease or three-vessel ..
  23. ncbi Acute kidney injury following coronary artery bypass surgery and long-term risk of heart failure
    Daniel Olsson
    Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden
    Circ Heart Fail 6:83-90. 2013
    Acute kidney injury (AKI) after coronary artery bypass grafting (CABG) is common and increases the risk of postoperative complications and mortality...
  24. ncbi The influence of propofol or desflurane on postoperative cognitive dysfunction in patients undergoing coronary artery bypass surgery
    C F Royse
    Anaesthesia and Pain Management Unit, Department of Pharmacology, University of Melbourne, Carlton, Victoria
    Anaesthesia 66:455-64. 2011
    ..on the incidence of postoperative cognitive dysfunction in a randomised trial of 180 patients undergoing coronary artery bypass surgery...
  25. pmc Preoperative proteinuria predicts adverse renal outcomes after coronary artery bypass grafting
    Tao Min Huang
    Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, 7 Chung Shan South Road, Zhong Zheng District, Taipei 100, Taiwan
    J Am Soc Nephrol 22:156-63. 2011
    ..Here, we performed a secondary analysis of a prospectively enrolled cohort of adult patients undergoing coronary artery bypass grafting (CABG) at a medical center and its two affiliate hospitals between 2003 and 2007...
  26. ncbi Neutrophil gelatinase associated lipocalin as a biomarker for acute kidney injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass
    A Prabhu
    Department of Biochemistry, MMM Academy of Medical Sciences, Mogapair, Chennai 600037, India
    Ann Vasc Surg 24:525-31. 2010
    ..plasma neutrophil gelatinase associated lipocalin (NGAL) levels as a predictor of renal injury in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) along with markers of oxidative stress.
  27. ncbi Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting
    Patrick H Gibson
    Department of Cardiology, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, United Kingdom
    Am J Cardiol 105:186-91. 2010
    ..the relation between the N/L ratio and postoperative atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting...
  28. ncbi Plasma n-3 and n-6 fatty acids and the incidence of atrial fibrillation following coronary artery bypass graft surgery
    Gudrun V Skuladottir
    Department of Physiology, School of Health Sciences, University of Iceland, Reykjavik, Iceland
    Eur J Clin Invest 41:995-1003. 2011
    ..We examined the association between n-3 LC-PUFA and n-6 LC-PUFA in plasma phospholipids (PL) and POAF in patients undergoing coronary artery bypass grafting (CABG).
  29. ncbi Meta-analysis of randomised trials comparing the effectiveness of miniaturised versus conventional cardiopulmonary bypass in adult cardiac surgery
    F Biancari
    Division of Cardio Thoracic and Vascular Surgery, Department of Surgery, Oulu University Hospital, Oulu, Finland
    Heart 95:964-9. 2009
    ..The aim of this meta-analysis is to summarise the results of prospective, randomised studies comparing miniaturised (Mini-CPB) versus conventional cardiopulmonary bypass (C-CPB)...
  30. ncbi Results of percutaneous coronary intervention of the unprotected left main coronary artery in 143 patients and comparison of 30-day mortality to results of coronary artery bypass grafting
    Christophe Dubois
    Department of Cardiology, University Hospitals Leuven, Leuven, Belgium
    Am J Cardiol 101:75-81. 2008
    ..Mortality remains high in very high-risk patients unsuitable for surgery. However, in selected indications, PCI of the LMCA can offer an alternative to surgery, especially when using drug-eluting stents...
  31. ncbi The clinical and economic impact of deep chest surgical site infections following coronary artery bypass graft surgery
    C S Hollenbeak
    Pennsylvania State College of Medicine, Hershey 17033, USA
    Chest 118:397-402. 2000
    To examine how deep chest surgical site infections following coronary artery bypass graft (CABG) surgery impact hospital inpatient length of stay (LOS), costs, and mortality.
  32. ncbi Cellular, molecular and immunological mechanisms in the pathophysiology of vein graft intimal hyperplasia
    Amit K Mitra
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    Immunol Cell Biol 84:115-24. 2006
    ..Invasive techniques such as coronary artery bypass grafting are used to alleviate the sequelae of arterial occlusion...
  33. ncbi Transit-time flow measurement is essential in coronary artery bypass grafting
    Derek K H Leong
    Faculty of Medicine, National University of Singapore, Singapore, Singapore
    Ann Thorac Surg 79:854-7; discussion 857-8. 2005
    Patent bypass grafts are fundamental to successful coronary artery bypass grafting. Intraoperative flow measurement through newly constructed grafts is a test of patency...
  34. ncbi ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft S
    Kim A Eagle
    Circulation 110:e340-437. 2004
  35. ncbi Effect of arterial revascularisation on survival: a systematic review of studies comparing bilateral and single internal mammary arteries
    D P Taggart
    Oxford Heart Centre, John Radcliffe Hospital, OX3 9DU, Oxford, UK
    Lancet 358:870-5. 2001
    b>Coronary artery bypass grafting (CABG) is the commonest major operation in most developed countries...
  36. ncbi Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: a randomized study of cardiovascular effects and quality of life
    Trine T Moholdt
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Am Heart J 158:1031-7. 2009
    ..We compared the effects of aerobic interval training (AIT) versus moderate continuous training (MCT) on Vo(2peak) and quality of life after coronary artery bypass grafting (CABG).
  37. ncbi Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting
    Robert J Scheubel
    Department of Cardiothoracic Surgery, and Institute of Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Am Coll Cardiol 42:2073-80. 2003
    The effect of patient age on circulating endothelial progenitor cells (EPCs) and their mobilization during coronary artery bypass grafting (CABG) was assessed.
  38. ncbi Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial
    John H Alexander
    Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 294:2446-54. 2005
    b>Coronary artery bypass graft (CABG) surgery with autologous vein grafting is commonly performed. Progressive neointimal hyperplasia, however, contributes to considerable vein graft failure...
  39. ncbi Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from a Department of Veterans Affairs Cooperative Study
    Steven Goldman
    Southern Arizona VA Health Care System and the University of Arizona Sarver Heart Center, Tucson, Arizona, USA
    J Am Coll Cardiol 44:2149-56. 2004
    ..This study defined long-term patency of saphenous vein grafts (SVG) and internal mammary artery (IMA) grafts...
  40. ncbi Beneficial effects of intravenously administered N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a prospective randomized study
    M C Heidt
    Cardiology, University Clinic Giessen, 35392 Giessen, Germany
    Thorac Cardiovasc Surg 57:276-80. 2009
    Atrial fibrillation (AF) is a common complication after coronary artery bypass grafting operation (CABG). Experimental data have shown antiarrhythmic effects of n-3 polyunsaturated fatty acids (PUFA) on myocardial cells...
  41. ncbi Morbid results of prolonged intubation after coronary artery bypass surgery
    A J Cohen
    Department of Cardiothoracic Surgery, Wolfson Medical Center, Holon affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Chest 118:1724-31. 2000
    This study evaluated the morbid results of prolonged intubation after coronary artery bypass grafting (CABG).
  42. ncbi Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients
    Leo van de Watering
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 46:1712-8. 2006
    ..The aim in this study was to investigate the possible role of the storage time of RBC transfusions on the outcome of coronary artery bypass graft (CABG) surgery patients.
  43. ncbi Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies
    Christof Stamm
    Department of Cardiac Surgery, University of Rostock, Rostock, Germany
    J Thorac Cardiovasc Surg 133:717-25. 2007
    ..assessed the feasibility and safety of intramyocardial CD133+ bone marrow cell injection together with coronary artery bypass grafting (CABG)...
  44. ncbi Remote ischaemic preconditioning in coronary artery bypass surgery: a meta-analysis
    Fabrizio D'Ascenzo
    Division of Cardiology, University of Turin, Turin, Italy
    Heart 98:1267-71. 2012
    Randomised trials exploring remote ischaemic preconditioning (RIPC) in patients undergoing coronary artery bypass graft (CABG) surgery have yielded conflicting data regarding potential cardiovascular and renal protection, and are ..
  45. ncbi Do off-pump techniques reduce the incidence of postoperative atrial fibrillation in elderly patients undergoing coronary artery bypass grafting?
    Thanos Athanasiou
    The National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Department of Cardiothoracic Surgery, St Mary s Hospital and Royal Brompton Hospital, London, United Kingdom
    Ann Thorac Surg 77:1567-74. 2004
    Atrial fibrillation is the most common postoperative complication in patients undergoing coronary artery bypass grafting (CABG) with advancing age having been shown to have a significant association with its incidence...
  46. ncbi Storage time of allogeneic red blood cells is associated with risk of severe postoperative infection after coronary artery bypass grafting
    Jan Jesper Andreasen
    Department of Cardiothoracic Surgery, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Eur J Cardiothorac Surg 39:329-34. 2011
    ..We therefore examined the association between the age of transfused RBCs and development of severe postoperative infection following coronary artery bypass grafting (CABG) in a large population-based cohort study.
  47. pmc Delirium after coronary artery bypass graft surgery and late mortality
    Rebecca F Gottesman
    Department of Neurology, Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Ann Neurol 67:338-44. 2010
    ..The primary goal of this study was to determine whether patients with delirium after coronary artery bypass graft (CABG) surgery have higher long-term out-of-hospital mortality when compared with CABG patients ..
  48. ncbi Lack of protective role of HDL-C in patients with coronary artery disease undergoing elective coronary artery bypass grafting
    Emiliano Angeloni
    Department of Cardiac Surgery, University of Rome Sapienza, Ospedale Sant Andrea, Rome, Italy
    Eur Heart J 34:3557-62. 2013
    ..In the present study, we hypothesize that HDL-C may lose their protective role in the secondary prevention of coronary artery disease (CAD)...
  49. pmc Measurement of post-operative cognitive dysfunction after cardiac surgery: a systematic review
    J L Rudolph
    Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Division of Aging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02130, USA
    Acta Anaesthesiol Scand 54:663-77. 2010
    ..There is marked variability in the measurement and definition of POCD. This heterogeneity may impede progress by reducing the ability to compare studies on the causes and treatment of POCD...
  50. ncbi Impact of off-pump coronary artery bypass surgery on systemic inflammation: current best available evidence
    Shahzad G Raja
    Department of Cardiac Surgery, Western Infirmary Glasgow, Glasgow, United Kingdom
    J Card Surg 22:445-55. 2007
    The systemic inflammatory response after coronary artery bypass grafting using cardiopulmonary bypass (CPB) contributes substantially to postoperative organ dysfunction and coagulation disorders...
  51. ncbi Six-year follow-up of a randomised controlled trial examining hospital versus home-based exercise training after coronary artery bypass graft surgery
    Kelly M Smith
    Department of Medicine, University of Illinois College of Medicine at Chicago, Section of Health Promotion Research, Chicago, Illinois, USA
    Heart 97:1169-74. 2011
    ..To compare the long-term effectiveness of hospital versus telephone-monitored home-based exercise training during cardiac rehabilitation (CR) on exercise capacity and habitual physical activity...
  52. ncbi Hypoxaemia after cardiac surgery: clinical application of a model of pulmonary gas exchange
    S Kjaergaard
    Aalborg Hospital, Department of Anaesthesiology, Aalborg, Denmark
    Eur J Anaesthesiol 21:296-301. 2004
    ..Ventilation/perfusion mismatch is quantified by deltaPO2, which is the drop in oxygen pressure from alveoli to lung capillaries. Shunt and deltaPO2 were used to describe changes in oxygenation after coronary artery bypass grafting.
  53. ncbi Effect of duration of red blood cell storage on early and late mortality after coronary artery bypass grafting
    Albert H M van Straten
    Department of Cardio Thoracic Surgery, Catharina Hospital, Eindhoven, The Netherlands
    J Thorac Cardiovasc Surg 141:231-7. 2011
    ..We tested the hypothesis that longer storage of transfused red blood cells increases the risk of early and late mortality in patients who undergo coronary artery bypass grafting.
  54. ncbi Induced remote ischemic pre-conditioning on ischemia-reperfusion injury in patients undergoing coronary artery bypass
    Nasir Ali
    Department of Cardiac Surgery, Armed Forces Institute of Cardiology, National Institute of Heart Diseases, Rawalpindi, Pakistan
    J Coll Physicians Surg Pak 20:427-31. 2010
    To determine the role of remote ischemic pre-conditioning (rIPC) on myocardium, against ischemia reperfusion injury in patients undergoing coronary artery bypass graft (CABG) surgery by measuring CKMB levels.
  55. ncbi Cardiac surgery in Germany during 2011: a report on behalf of the German Society for Thoracic and Cardiovascular Surgery
    Anne Kathrin Funkat
    Department of Cardiac Surgery, Herzzentrum, University of Leipzig, Leipzig, Germany
    Thorac Cardiovasc Surg 60:371-82. 2012
    ..4% in 2010. Hospital mortality in 41,976 isolated coronary artery bypass graft procedures (14.7% off-pump) was 2.9%...
  56. pmc Predictors of atrial fibrillation following coronary artery bypass surgery
    Marijana Tadic
    Clinical Centre of Serbia, Clinic for Cardiology, Belgrade, Serbia
    Med Sci Monit 17:CR48-55. 2011
    New-onset atrial fibrillation is the most common form of rhythm disturbance following coronary artery bypass grafting surgery (CABG). It is still unclear which factors have a significant impact on its occurrence after this procedure...
  57. ncbi Psychological risk factors for increased post-operative length of hospital stay following coronary artery bypass graft surgery
    Melissa Oxlad
    School of Psychology, Flinders University, Adelaide, South Australia, Australia
    J Behav Med 29:179-90. 2006
    To date, researchers have examined the role of psychological factors in longer-term adaptation to coronary artery bypass graft surgery (CABG), but few have investigated the role of such factors in the immediate post-operative period...
  58. ncbi Depression is associated with increased mortality 10 years after coronary artery bypass surgery
    Ingrid Connerney
    Division of Quality and Safety, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Psychosom Med 72:874-81. 2010
    To determine if depression is independently associated with cardiac and all-cause mortality 10 years after coronary artery bypass graft (CABG) surgery...
  59. ncbi Does location of the second internal thoracic artery graft influence outcome of coronary artery bypass grafting?
    Joseph F Sabik
    Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, 9500 Euclid Avenue Desk F24, Cleveland, OH 44195, USA
    Circulation 118:S210-5. 2008
    ....
  60. ncbi Impact of chronic obstructive pulmonary disease severity on surgical outcomes in patients undergoing non-emergent coronary artery bypass grafting
    Hesham Z Saleh
    Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK
    Eur J Cardiothorac Surg 42:108-13; discussion 113. 2012
    ..Our objective was to analyse the prognostic implication of COPD stages as defined by the Global Initiative for Chronic Obstructive Lung Disease...
  61. ncbi Short-term effects of inspiratory muscle training in coronary artery bypass graft surgery: a randomized controlled trial
    Sema Savci
    School of Physical Therapy and Rehabilitation, Dokuz Eylul University, Izmir, Turkey
    Scand Cardiovasc J 45:286-93. 2011
    To investigate the efficiency of inspiratory muscle training (IMT) on postoperative respiratory muscle strength, functional capacity, quality of life, and psychosocial status in patients with coronary artery bypass graft (CABG) surgery.
  62. ncbi Variation in coronary artery bypass grafting, angioplasty, cataract surgery, and hip replacement rates among primary care groups in London: association with population and practice characteristics
    Azeem Majeed
    School of Public Policy, University College London
    J Public Health Med 24:21-6. 2002
    ..However, no studies in the United Kingdom have yet examined the variation in the use of important groups of surgical procedures among primary care groups...
  63. ncbi Prognostic value of chronic obstructive pulmonary disease in coronary artery bypass grafting
    Rafael García Fuster
    University General Hospital of Valencia, Valencia 46010, Spain
    Eur J Cardiothorac Surg 29:202-9. 2006
    ..Our objective was to analyze its prognostic relevance considering preoperative pulmonary function parameters...
  64. ncbi Off-pump vs. on-pump coronary artery bypass surgery: an updated meta-analysis and meta-regression of randomized trials
    Jonathan Afilalo
    Division of Cardiology, Department of Medicine, SMBD Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
    Eur Heart J 33:1257-67. 2012
    The benefits of off-pump coronary artery bypass (OPCAB) continue to be debated, in part due to the fact that pooled effects fail to consider differences in trial and patient characteristics...
  65. ncbi Subclinical changes in serum creatinine and mortality after coronary artery bypass grafting
    Daniel A Tolpin
    Division of Cardiovascular Anesthesiology, The Texas Heart Institute, St Luke s Episcopal Hospital, Houston, TX 77030, USA
    J Thorac Cardiovasc Surg 143:682-688.e1. 2012
    ....
  66. ncbi Does preoperative hemoglobin independently predict short-term outcomes after coronary artery bypass graft surgery?
    Melanie L Bell
    Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
    Ann Thorac Surg 86:1415-23. 2008
    The role of preoperative hemoglobin in predicting short-term coronary artery bypass graft (CABG) surgery outcomes has not been well established...
  67. ncbi Location of the second internal mammary artery graft does not influence outcome of coronary artery bypass grafting
    Paul A Kurlansky
    Florida Heart Research Institute, Miami, Florida 33137, USA
    Ann Thorac Surg 91:1378-83; discussion 1383-4. 2011
    Although the use of two internal mammary arteries (IMA) in coronary artery bypass graft surgery has been associated with improved patient survival and clinical status, the optimal use of the second IMA graft remains controversial...
  68. ncbi Compliant model of a coupled sequential coronary arterial bypass graft: effects of vessel wall elasticity and non-Newtonian rheology on blood flow regime and hemodynamic parameters distribution
    Foad Kabinejadian
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Med Eng Phys 34:860-72. 2012
    ..Hence, the inclusion of wall compliance and non-Newtonian rheology in flow simulation of blood vessels can be essential in quantitative and comparative investigations...
  69. ncbi Comparative survival of dialysis patients in the United States after coronary angioplasty, coronary artery stenting, and coronary artery bypass surgery and impact of diabetes
    Charles A Herzog
    Cardiovascular Special Studies Center, United States Renal Data System, Minneapolis, Minn, USA
    Circulation 106:2207-11. 2002
    ..The optimal method of coronary revascularization in dialysis patients is controversial. The purpose of this study was to compare the long-term survival of dialysis patients in the United States after PTCA, coronary stenting, or CABG...
  70. ncbi Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials
    Mark A Hlatky
    Stanford University School of Medicine, Stanford, CA, USA
    Lancet 373:1190-7. 2009
    b>Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are alternative treatments for multivessel coronary disease...
  71. ncbi Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: a meta-analysis
    Peter Donndorf
    Department of Cardiac Surgery, University of Rostock, Rostock, Germany
    J Thorac Cardiovasc Surg 142:911-20. 2011
    ..clinical studies have suggested that intramyocardial bone marrow stem cell transplantation combined with coronary artery bypass grafting might improve left ventricular function in the setting of chronic ischemic heart disease...
  72. ncbi N-3 polyunsaturated fatty acids reduces post-operative atrial fibrillation incidence in patients undergoing "on-pump" coronary artery bypass graft surgery
    Mario Sorice
    Department of Cardiac Surgery, S Anna e S Sebastiano Hospital, Caserta, Italy Via F Palasciano, 81100 CE, Italy
    Monaldi Arch Chest Dis 76:93-8. 2011
    The aim of this study was to evaluate the efficacy of preoperative and postoperative therapy with n-3 polyunsaturated fatty acids in reducing the incidence of atrial fibrillation after coronary artery bypass graft surgery.
  73. ncbi Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the clopidogrel after surgery for coronary artery disease (CASCADE) Trial
    Alexander Kulik
    Lynn Heart and Vascular Institute, University of Ottawa Heart Institute, Ontario, Canada
    Circulation 122:2680-7. 2010
    ..in animal studies and therefore may reduce saphenous vein graft (SVG) intimal hyperplasia after coronary artery bypass grafting...
  74. ncbi Meta-analysis of clinical studies comparing coronary artery bypass grafting with percutaneous coronary intervention and drug-eluting stents in patients with unprotected left main coronary artery narrowings
    Michael S Lee
    Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Am J Cardiol 105:1070-5. 2010
    The aim of this study was to compare the safety and efficacy of coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) using drug-eluting stents (DES) in patients with unprotected left main coronary artery (..
  75. ncbi A decade of change--risk profiles and outcomes for isolated coronary artery bypass grafting procedures, 1990-1999: a report from the STS National Database Committee and the Duke Clinical Research Institute. Society of Thoracic Surgeons
    T Bruce Ferguson
    The Society of Thoracic Surgeons National Database Committee, Chicago, Illinois, USA
    Ann Thorac Surg 73:480-9; discussion 489-90. 2002
    ..Using this database we examined changes in the risk profile of patients undergoing isolated coronary artery bypass grafting (CABG) and their outcomes during the decade 1990 to 1999.
  76. ncbi The effect of biventricular pacing after coronary artery bypass grafting: a prospective randomized trial of different pacing modes in patients with reduced left ventricular function
    Frank Eberhardt
    Medical Clinic II, University of Lubeck, Lubeck, Germany
    J Thorac Cardiovasc Surg 137:1461-7. 2009
    ..of biventricular pacing immediately after weaning from cardiopulmonary bypass in patients undergoing coronary artery bypass grafting, but whether these effects can be maintained for the early postoperative period is unclear...
  77. ncbi The effect of biventricular pacing on cardiac function after weaning from cardiopulmonary bypass in patients with reduced left ventricular function: a pressure-volume loop analysis
    Thorsten Hanke
    Department of Cardiac and Thoracic Vascular Surgery, University of Lubeck, Lubeck, Germany
    J Thorac Cardiovasc Surg 138:148-56. 2009
    Patients with severely reduced left ventricular function undergoing coronary artery bypass grafting have increased complication rates...
  78. ncbi Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation
    Petra Kleinbongard
    FRCP, Institut fur Pathophysiologie, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Circ Res 108:344-52. 2011
    ..Stent implantation into atherosclerotic plaques releases, apart from particulate debris, soluble substances that contribute to impaired microvascular perfusion...
  79. pmc Superiority of moderate control of hyperglycemia to tight control in patients undergoing coronary artery bypass grafting
    Castigliano M Bhamidipati
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 141:543-51. 2011
    ..We sought to determine whether tight control or moderate glycemic control is optimal after coronary artery bypass grafting.
  80. ncbi Multiple arterial grafts improve late survival of patients undergoing coronary artery bypass graft surgery: analysis of 8622 patients with multivessel disease
    Chaim Locker
    Division of Cardiovascular Surgery, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 126:1023-30. 2012
    Use of the left internal mammary artery (LIMA) in multivessel coronary artery disease improves survival after coronary artery bypass graft surgery; however, the survival benefit of multiple arterial (MultArt) grafts is debated.
  81. ncbi Determinant factors of renal failure after coronary artery bypass grafting with on-pump technique
    Hossein Ahmadi
    Department of Cardiovascular Surgery, Medical Sciences, Tehran Heart Center, University of Tehran, North Kargar Street, Tehran, Iran
    Med Princ Pract 18:300-4. 2009
    The aim of the present study was to investigate the determinant factors of acute renal failure (ARF) after isolated on-pump coronary artery bypass grafting (CABG).
  82. ncbi 30-day readmissions after coronary artery bypass graft surgery in New York State
    Edward L Hannan
    University at Albany, State University of New York, Albany 12144 3456, USA
    JACC Cardiovasc Interv 4:569-76. 2011
    ..The aim of this study was to identify reasons for and predictors of readmission...
  83. ncbi Anti-inflammatory effects of alkaline phosphatase in coronary artery bypass surgery with cardiopulmonary bypass
    Suzanne Kats
    Catharina Hospital, Department of Cardiothoracic Surgery, Eindhoven, The Netherlands
    Recent Pat Inflamm Allergy Drug Discov 3:214-20. 2009
    ..administration of bovine intestinal alkaline phosphatase on surgical complications in patients undergoing coronary artery bypass grafting...
  84. ncbi Outcomes in patients with de novo left main disease treated with either percutaneous coronary intervention using paclitaxel-eluting stents or coronary artery bypass graft treatment in the Synergy Between Percutaneous Coronary Intervention with TAXUS and C
    Marie Claude Morice
    Institut Hospitalier Jacques Cartier, 6 avenue du Noyer Lambert, Massy, France
    Circulation 121:2645-53. 2010
    ..SYNTAX) trial was designed to assess the optimal revascularization strategy between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG), for patients with left main (LM) and/or 3-vessel coronary disease.
  85. ncbi Long-term safety and efficacy of percutaneous coronary intervention with stenting and coronary artery bypass surgery for multivessel coronary artery disease: a meta-analysis with 5-year patient-level data from the ARTS, ERACI-II, MASS-II, and SoS trials
    Joost Daemen
    Thoraxcenter, Ba 583, Dr Molewaterplein 40, 3015 GD Rotterdam, Netherlands
    Circulation 118:1146-54. 2008
    ..studied clinical outcomes after percutaneous coronary intervention (PCI) with bare metal stenting versus coronary artery bypass grafting (CABG) are underpowered to properly assess safety end points like death, stroke, and myocardial ..
  86. ncbi Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial
    Ismail El-Hamamsy
    Research Center and Department of Surgery, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 133:7-12. 2007
    ..The objective of this study was to evaluate the effects of intravenous N-acetylcysteine on clinical and biochemical outcomes after coronary artery bypass surgery with cardiopulmonary bypass.
  87. ncbi The role of temporary biventricular pacing in the cardiac surgical patient with severely reduced left ventricular systolic function
    Rudolph F Evonich
    William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Thorac Cardiovasc Surg 136:915-21. 2008
    ..The objective was to evaluate the effects of atrial synchronous biventricular pacing in postoperative patients with severe cardiomyopathy...
  88. ncbi Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial
    V Venugopal
    The Hatter Cardiovascular Institute, University College London Hospital, 67 Chenies Mews, London WC1E 6HX, UK
    Heart 95:1567-71. 2009
    ..preconditioning (RIPC) induced by brief ischaemia and reperfusion of the arm reduces myocardial injury in coronary artery bypass (CABG) surgery patients receiving predominantly cross-clamp fibrillation for myocardial protection...
  89. ncbi Preoperative C-reactive protein levels predict 9-month mortality after coronary artery bypass grafting surgery for the treatment of left main coronary artery stenosis
    Tullio Palmerini
    Department of Cardiology, Policlinico S Orsola, University of Bologna, Italy
    Eur J Cardiothorac Surg 31:685-90. 2007
    ..However, there are no data regarding the impact of C-reactive protein on mid-term mortality in patients with unprotected left main coronary artery stenosis treated with coronary artery bypass graft.
  90. ncbi The combination of propranolol and magnesium does not prevent postoperative atrial fibrillation
    A J Solomon
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    Ann Thorac Surg 69:126-9. 2000
    ..However, the use of magnesium is more controversial. It was our hypothesis that adjunctive magnesium sulfate would improve the efficacy of beta-blockers alone in the prevention of postoperative atrial fibrillation...
  91. ncbi Achieving and sustaining improved quality: lessons from New York State and cardiac surgery
    Mark R Chassin
    Department of Health Policy, Mount Sinai School of Medicine, New York City, USA
    Health Aff (Millwood) 21:40-51. 2002
    ..the New York State Department of Health has published annual data on risk-adjusted mortality following coronary artery bypass graft surgery by hospital and surgeon...
  92. ncbi Acute renal failure following open heart surgery: risk factors and prognosis
    Ilknur Bahar
    Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
    Perfusion 20:317-22. 2005
    ..Acute renal failure (ARF) development after cardiac surgery carries high mortality and morbidity...
  93. ncbi Medication adherence following coronary artery bypass graft surgery: assessment of beliefs and attitudes
    Ujjaini Khanderia
    College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Ann Pharmacother 42:192-9. 2008
    The medication management of patients following coronary artery bypass graft (CABG) surgery may include antiplatelet agents, beta-blockers, angiotensin-converting enzyme inhibitors, and statins...
  94. ncbi Outcomes and perioperative hyperglycemia in patients with or without diabetes mellitus undergoing coronary artery bypass grafting
    Carlos A Estrada
    Department of Internal Medicine, The Brody School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA
    Ann Thorac Surg 75:1392-9. 2003
    ..between perioperative hyperglycemia and outcomes in patients with and without diabetes mellitus undergoing coronary artery bypass grafting is not well defined...
  95. ncbi The impact of epiaortic ultrasonographic scanning on the risk of perioperative stroke
    Bartolo Zingone
    Division of Cardiac Surgery, Ospedali Riuniti, Strada di Fiume 447, 34100 Trieste, Italy
    Eur J Cardiothorac Surg 29:720-8. 2006
    ..To assess the impact of epiaortic scanning on the incidence of perioperative stroke in patients undergoing cardiac surgery...
  96. pmc Clinical implications of the new definition of myocardial infarction
    John K French
    Cardiology Department, Green Lane Hospital, Auckland, New Zealand
    Heart 90:99-106. 2004
  97. ncbi Daily comparison of respiratory functions between on-pump and off-pump patients undergoing CABG
    Serdar Cimen
    Thoracic and Cardiovascular Surgery Department, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey
    Eur J Cardiothorac Surg 23:589-94. 2003
    ....
  98. ncbi 10-year follow-up of patients with and without mediastinitis
    John H Braxton
    Maine Medical Center, Portland, ME, USA
    Semin Thorac Cardiovasc Surg 16:70-6. 2004
    ..86,2.58; P < 0.001). The adjusted hazard ratios for patients who survived 6 months postsurgery was 1.70 (CI95% = 1.36,2.13; P < 0.001). Mediastinitis is associated with a marked increase in both acute and long-term mortality rates...
  99. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
    ..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
  100. ncbi Effect of diabetes on early and late survival after isolated first coronary bypass surgery in multivessel disease
    Antonio Maria Calafiore
    Department of Cardiology and Cardiac Surgery, University G D Annunzio, Chieti, Italy
    J Thorac Cardiovasc Surg 125:144-54. 2003
    ..Diabetes has not yet been investigated as a risk factor for early and late cardiac-related death...
  101. ncbi The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 1--coronary artery bypass grafting surgery
    David M Shahian
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Ann Thorac Surg 88:S2-22. 2009
    ..To adjust for these and other changes, all STS risk models have undergone periodic revisions. This report provides a detailed description of the 2008 STS risk model for coronary artery bypass grafting surgery (CABG).

Research Grants68

  1. Transfusion Trigger Trial in Coronary Artery Disease: A Pilot Study
    JEFFREY LEE CARSON; Fiscal Year: 2010
    ..recurrent myocardial infarction, emergent percutaneous intervention (angioplasty or stent insertion) or coronary artery bypass graft surgery within 30 days of enrollment compared to a restrictive transfusion strategy...
  2. Inhibition of GRK2 to Prevent Ventricular Remodeling and Heart Failure After CABG
    Shahab A Akhter; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite complete revascularization by coronary artery bypass grafting (CABG), long-term survival is markedly inferior for patients who present with depressed left ventricular function post-myocardial ..
  3. PTEN Gene Therapy for Vein Graft Disease
    Christopher D Kontos; Fiscal Year: 2010
    ..E2F transcription factor demonstrated no benefit for the prevention of vein graft failure in peripheral or coronary artery bypass grafting (CABG). Thus, there is a critical need for novel approaches to prevent vein graft failure...
  4. The Fat1 Cadherin in Atherosclerotic Vascular Disease
    NICHOLAS E SIBINGA; Fiscal Year: 2013
    ..process in the pathogenesis of clinically important vascular diseases such as atherosclerosis, restenosis, coronary artery bypass graft failure, and arteriosclerosis that occurs in transplanted hearts and kidneys...
  5. Treatment and Risk Factor Determinants of Cardiovascular Outcomes in BARI 2D
    Maria Mori Brooks; Fiscal Year: 2013
    ..When coronary artery bypass surgery (CABG) was pre-specified as the intended method of revascularization, prompt revascularization ..
  6. SMOOTH MUSCLE CELL PROLIFERATION IN HUMAN CORONARY ARTERY BYPASS GRAFTS
    Devendra K Agrawal; Fiscal Year: 2012
    ..Invasive techniques such as coronary artery bypass grafting (CABG) using the saphenous vein (SV) or internal mammary artery (IMA) are used to alleviate the ..
  7. Acute Coronary Syndrome Outcomes for Medicare Patients
    SALLY STEARNS; Fiscal Year: 2009
    ..early mechanical myocardial revascularization with either percutaneous intervention with stents (PCIS) or coronary artery bypass grafting (CABG)...
  8. Prasugrel for prevention of early saphenous vein graft thrombosis
    Emmanouil Brilakis; Fiscal Year: 2013
    ..However, in patients who undergo coronary artery bypass graft surgery, it remains unknown whether prasugrel may decrease thrombus formation in saphenous vein ..
  9. ACCF-STS Database Collaboration on the Comparative Effectiveness of PCI and CABG
    William S Weintraub; Fiscal Year: 2010
    ..of the two forms of coronary revascularization therapy, percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery...
  10. Autogeneic Mitochondria: Surgical Cardioprotection
    James D McCully; Fiscal Year: 2013
    ..a time frame reasonable within the clinical interventions of both coronary artery bypass grafting (CABG) and percutaneous coronary intervention for coronary revascularization for ST segment ..
  11. Hepcidin Lateral Flow Device for Prediction of Acute Kidney Injury
    MARK EDWARD WESTERMAN; Fiscal Year: 2013
    ..AKI) is a common, severe complication of cardiopulmonary bypass (CPB) assisted surgeries, and include coronary artery bypass grafts, valve replacements, aortic aneurisms, and organ transplants...
  12. Activation of sirtuins to prevent adverse cardiac remodeling after CABG
    Mahesh P Gupta; Fiscal Year: 2013
    ..Even after complete revascularization by coronary artery bypass grafting (CABG) patients with MI (myocardial infarction) often develop adverse ventricular remodeling in ..
  13. Antithrombotic Aptamers and Antidotes
    BRUCE ALAN SULLENGER; Fiscal Year: 2013
    ..a number of clinical procedures including percutaneous coronary interventions (PCI, "angioplasties"), coronary artery bypass graft (CABG) surgery and other surgeries, as well as dialysis...
  14. Mitochondrial Dysfunction and Susceptibility to Atrial Fibrillation in the Elderl
    Arshad Jahangir; Fiscal Year: 2013
    ..These aims will be achieved using atrial tissue obtained from patients undergoing coronary artery bypass surgery without or with risk factors for AF (heart failure, hypertension, or mitral regurgitation) or a ..
  15. Prolonged Clopidogrel Use After Drug-Eluting and Bare-Metal Coronary Stenting
    Scott Kinlay; Fiscal Year: 2013
    ..on the secondary endpoints of cardiac death, ischemic stroke, coronary revascularization with PCI or coronary artery bypass surgery, and major bleeding...
  16. Methods To Reduce Vein Harvest Injury
    Joyce Cheung-Flynn; Fiscal Year: 2013
    ..human saphenous vein (HSV) continues to be the most widely used conduit for approximately 1,000,000 coronary artery bypass grafting (CABG) and peripheral vascular (PV) revascularization procedures performed each year...
  17. Racial disparities in access to high quality hospitals for coronary heart disease
    Ioana Popescu; Fiscal Year: 2013
    ..are less likely to receive care for acute myocardial infarction, percutaneous coronary intervention, and coronary artery bypass surgery in high quality hospitals...
  18. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2009
    ..aims in the R21 phase, we propose in the R33 phase a prospective study involving 400 patients undergoing coronary artery bypass graft surgery and 350 patients admitted to the medical intensive care unit...
  19. MYOCARDIAL PROTECTION: REPERFUSION INJURY AMELIORATION
    James D McCully; Fiscal Year: 2010
    Demographic studies have shown that the mean age of patients requiring coronary artery bypass surgery (CABG) is 68 years with approximately 44% of these patients being female...
  20. Moral Hazard in Less Invasive Surgical Technology for Coronary Artery Disease
    Michael Grossman; Fiscal Year: 2011
    ..Percutaneous coronary intervention (PCI)--the newer and less invasive procedure-- and coronary artery bypass graft (CABG) surgery are the surgical interventions for CAD considered...
  21. Small heat shock proteins in surgically-induced myocardial stunning
    Richard T Clements; Fiscal Year: 2012
    The majority of coronary artery bypass grafting (CABG) and valve repair surgeries use cardioplegia and cardiopulmonary bypass (CP/CPB) to respectively arrest the heart and systemically circulate oxygenated blood...
  22. CaMKII regulates key mechanisms of vascular response to injury in vivo
    ISABELLA MARIA GRUMBACH; Fiscal Year: 2013
    ..Neointima formation and remodeling occur in vein graft failure after coronary artery bypass surgery, after balloon angioplasty and surgical endarterectomy and have a significant impact in terms of ..
  23. Smart Polymer Based MK2 Inhibitor to Suppress Vascular Graft Intimal Hyperplasia
    CRAIG LEWIS DUVALL; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Coronary artery bypass grafting (CABG) with autologous conduits effectively alleviates ischemic heart disease, but long-term graft patency is problematic...
  24. Miniaturized Distal Vibration System for Penetration of Vascular Occlusions
    STEPHANIE ADI HARRINGTON; Fiscal Year: 2010
    ..to the patient including reduced angina symptoms, improved left ventricular function, reduced need for Coronary Artery Bypass Graft (CABG), and a lower incidence of death or Myocardial Infarction (MI), but success rates are still ..
  25. STICH Trial-Statistical and Data Coordinatiing Center
    Kerry L Lee; Fiscal Year: 2010
    ..LV) dysfunction who have coronary artery disease (CAD) amenable to surgical revascularization: 1) Coronary artery bypass grafting (CABG) with intensive medical therapy (MED) improves long-term survival compared to MED alone; 2) ..
  26. STICH Trial-Coordinating Center
    Robert H Jones; Fiscal Year: 2011
    ..LV) dysfunction who have coronary artery disease (CAD) amenable to surgical revascularization: 1) Coronary artery bypass grafting (CABG) with intensive medical therapy (MED) improves long-term survival compared to MED alone; 2) ..
  27. PRESERVATION OF ENDOTHELIAL DEPENDENT RELAXATION
    Colleen M Brophy; Fiscal Year: 2013
    ..b>Coronary artery bypass grafting (CABG) is one of the most effective treatments for advanced coronary artery disease (CAD) and ..
  28. Differences in Quality, Cost, and Access between VA and Fee Basis CABG and PCI
    THOMAS MCMILLIN MADDOX; Fiscal Year: 2013
    ..Background. VHA purchases 19% of the elective Coronary Artery Bypass Graft (CABG) and 22% of the elective Percutaneous Coronary Intervention (PCI) that it sponsors for ..
  29. Pulmonary Rehabiltation before Lung Cancer Resection
    ROBERTO PABLO BENZO; Fiscal Year: 2013
    ..ultimately translate these improvements to all thoracic surgical procedures (such as esophageal cancer, coronary artery bypass surgery, etc...
  30. Comparative Effectiveness of Coronary Stents
    Edward Hannan; Fiscal Year: 2013
    ..are to compare longer-term mortality, myocardial infarction, and subsequent revascularization (PCI or coronary artery bypass graft surgery) for different pairs of coronary stents including BMS and the two generations of DES...
  31. Development of a Microstructurally Inspired and Compliance Matched Tissue Enginee
    JONATHAN PIETER VANDE GEEST; Fiscal Year: 2013
    ..In 2006 alone, CAD killed 425,245 people, and 176,138 coronary artery bypass grafts were implanted in patients [1]...
  32. Mussel-inspired self-healing hydrogels for vascular tissue repair
    DOMINIC EDWARD FULLENKAMP; Fiscal Year: 2012
    ..Currently, no synthetic materials exist that are ideal for small vessel grafts such as those used in coronary artery bypass. PUBLIC HEALTH RELEVANCE: For those patients who do not have suitable grafts (usually from veins in the ..
  33. Physician Referral &Mental-Disorder Related Disparities in CABG Quality
    Yue Li; Fiscal Year: 2011
    ..infarction, patients with mental disorders tend to under-use invasive cardiac procedures including coronary artery bypass graft (CABG) surgery...
  34. Using Clinically-Enhanced Claims Data to Guide Selection of Coronary Procedures
    HAROLD KILBURN; Fiscal Year: 2010
    ..provided by applicant): The goal of this research program is to examine the comparative effectiveness of coronary artery bypass graft (CABG) procedures and percutaneous coronary artery interventions (PCI)...
  35. Hormones and Sexual Function Predict Outcomes in Revascularized Men with Diabetes
    MARY A MCLAUGHLIN; Fiscal Year: 2013
    ..study is a multi-institutional randomized controlled trial comparing revascularization with either coronary artery bypass graft surgery (CABG) or with drug eluting stents in 2,400 patients with DM and multi-vessel CAD...
  36. Intracranial Atherosclerosis and predictors of Post-CABG Depression
    Hochang B Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Depression after coronary artery bypass graft (CABG) surgery is common (up to 40%) and increases risk of cardiac morbidity and mortality in the first year by more than two fold...
  37. A Bioactive Prosthetic Vascular Graft
    MATTHEW DOUGLAS PHANEUF; Fiscal Year: 2012
    ..grafts could be utilized in peripheral bypass (specifically below-knee reconstruction) as well as for coronary artery bypass. Thus, the potential annual market value for an "off-the-shelf" bioactive synthetic arterial bypass graft ..
  38. Blended Collaborative Care for Heart Failure and Co-Morbid Depression
    BRUCE LAWRENCE ROLLMAN; Fiscal Year: 2013
    ..and we recently demonstrated its clinical and cost-effectiveness at treating depression following coronary artery bypass graft surgery...
  39. Cell Instructive Materials For Engineering Vascular Grafts
    Robert E Akins; Fiscal Year: 2013
    ..are significant post-procedure problems with nearly 50% of autologous vein grafts used in peripheral or coronary artery bypass surgery failing over time due to maladaptive vessel remodeling...
  40. Cleveland Clinic Cardiothoracic Collaborative Clinical Center - C6
    Eugene Blackstone; Fiscal Year: 2013
    ..For 30+ years, the specialty has been dominated by coronary artery bypass grafting (CABG)...
  41. Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery
    Donald S Likosky; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): More than 400,000 coronary artery bypass grafting (CABG) procedures are performed every year in the United States (U.S.)...
  42. National Claims-Based Quality Measures for Surgical Site Infections
    Richard Platt; Fiscal Year: 2013
    ..We will 1) extend our previously successful claims-based surveillance following coronary artery bypass graft (CABG) surgery and hip arthroplasty to identify hospitals with an unusually high risk of SSI ..
  43. Mitral Regurgitation, Heart Failure and Coronary Disease: Benefits to MV Repair?
    Robert Michler; Fiscal Year: 2012
    ..second clinical trial will evaluate the appropriateness of current clinical practice which maintains that coronary artery bypass surgery (CABG) alone is sufficient to treat patients with coronary artery disease (CAD) and mild to ..
  44. Mannose binding lectin and outcomes following CABG
    GREGORY L contact STAHL; Fiscal Year: 2010
    ..occurs following successful thrombolytic therapy, percutaneous transluminal coronary angioplasty and coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB)...
  45. Myocardial Salvage With a Novel Reperfusion Therapy
    CONSTANCE WILSON; Fiscal Year: 2005
    ..Reperfusion injury of the heart following angioplasty procedures and coronary artery bypass graft surgery can affect the length of hospitalization, cost of hospitalization, functional capacity of ..
  46. Statistical Methods for Complex Data in Cardiovascular Disease
    Anastasios A Tsiatis; Fiscal Year: 2013
    ..g., in a study to compare endoscopic vs. open vein graft harvesting in patients undergoing coronary artery bypass graft surgery, Medicare claims data may misclassify the technique used in some pro- portion of patients...
  47. Biodegradable Synthetic Vascular Graft
    Yadong Wang; Fiscal Year: 2013
    ..immediately as a non-thrombogenic conduit for blood flow in a similar fashion as a saphenous vein in coronary artery bypass surgery...
  48. Long-Term Survival Following Coronary Revascularizations
    Edward Hannan; Fiscal Year: 2010
    ..Coronary revascularization procedures (i.e., coronary artery bypass graft (CABG) surgery and percutaneous coronary interventions (PCI)) are among the most frequently ..
  49. Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart Failure
    Ghassan S Kassab; Fiscal Year: 2013
    ..mathematical (finite element models of failing left ventricles that have been treated with Algisyl-LVR + coronary artery bypass grafting or Algisyl-LVR alone...
  50. Operative Strategies To Reduce Cerebral Embolic Events During CABG
    Michael Halkos; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): One of the most devastating complications of coronary artery bypass surgery (CABG) is postoperative stroke...
  51. Improved Estimates of the Comparative Treatment Effects of CABG and PCI
    Mark A Hlatky; Fiscal Year: 2010
    ..several statistical approaches to derive reliable treatment comparisons from observational data using coronary artery bypass graft surgery and coronary angioplasty as the test case...
  52. Hybrid revascularization vs percutaneous coronary intervention: A Planning Grant
    JOHN DANIEL contact PUSKAS; Fiscal Year: 2010
    ..The enormous and increasing prevalence of coronary artery disease (CAD), ongoing innovation in coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI) and medical therapy, as well as the costs of ..
  53. EQUITY OF INPATIENT SURGERY UTILIZATION IN CALIFORNIA
    Mita Giacomini; Fiscal Year: 1992
    ..The utilization of seven surgical procedures will be analyzed: coronary artery bypass, pacemaker implant, carotid endarterectomy, hip arthroplasty/replacement, lithotripsy, kidney ..
  54. Implantable construct for architectural control of re-vascularization of ischemic
    Michael Yang; Fiscal Year: 2013
    ..MicroBridge will serve as an adjunct delivered during coronary artery bypass surgery that would direct vascularization in the microvasculature to reperfuse regions of ischemia not ..
  55. Dynamic MRI for Myocardial Perfusion and Viability
    EDWARD VR DI BELLA; Fiscal Year: 2010
    ..the methods to longitudinal studies of patients undergoing bone marrow stem cell therapy as an adjunct to coronary artery bypass grafting...
  56. Enhancing vein graft viability
    MICHAEL JAMES OSGOOD; Fiscal Year: 2012
    ..Preliminary data has shown that 40% of HSV harvested for coronary artery bypass procedures have no functional viability...
  57. Development of an antidote-controlled FIXa inhibitor
    Christopher Rusconi; Fiscal Year: 2004
    Anticoagulant therapy is required to perform a number of clinical procedures including coronary artery bypass graft (CABG) surgery and other "open-heart" surgeries, percutaneous coronary interventions (PCI, "angioplasties"), and dialysis; ..
  58. Prevention of Vein Graft Intimal Hyperplasia with Optimized Human Apyrase
    Ridong Chen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The saphenous vein is the most commonly used graft for coronary artery bypass and peripheral bypass surgery, but has poor patency...
  59. Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
    Mias Pretorius; Fiscal Year: 2010
    ..In fact, approximately 20% of all blood products transfused are associated with coronary artery bypass grafting procedures...
  60. Cleveland Clinic Cardiothoracic Collaborative Clinical Center (C6)
    Bruce Lytle; Fiscal Year: 2013
    ..During the nearly 50-year history of cardiac surgery, 30+ years were dominated by coronary artery bypass grafting (CABG)...
  61. Reducing Risk in Cardiac Rehabilitation: Partners Together in Health (PaTH) Inter
    Bernice Yates; Fiscal Year: 2009
    ..by applicant): Long-term maintenance of lifestyle changes to reduce cardiovascular risk factors after coronary artery bypass graft (CABG) surgery is essential to positively influence health outcomes...
  62. Microparticles in stored RBC as potential mediators in transfusion complications
    Wenche Jy; Fiscal Year: 2012
    ..is a clinical study to directly test the hypothesis by administering to randomized patients scheduled for coronary artery bypass surgery either conventional PC (Group 1) or PC washed prior to transfusion to deplete MP (Group 2)...
  63. UTILIZATION OF RESEARCH ON CARDIOVASCULAR TECHNOLOGIES
    PAUL WORTMAN; Fiscal Year: 1990
    The proposed research seeks to use meta-analytic methods to exploit the rather considerable databases on coronary artery bypass graft surgery, lytic agents for myocardial infarction, carotid endarterectomy, and drug interventions for ..
  64. Simulation of Coronary Artery Bypass Graft and Surgical Ventricular Restoration
    JULIUS MATTEO GUCCIONE; Fiscal Year: 2010
    ..b>Coronary artery bypass grafting (CABG) and surgical ventricular restoration (SVR) are the two surgical options included in the ..
  65. Post Coronary Bypass Atrial Arrhythmic Prediction Rule
    Rod Passman; Fiscal Year: 2006
    The proposed study seeks to develop and validate a clinical prediction rule for post-coronary artery bypass grafting (CABG) atrial fibrillation and atrial flutter (AF)...
  66. RECEPTOR KINASE GENE THERAPY FOR NEOINTIMAL HYPERPLASIA
    Neil Freedman; Fiscal Year: 2002
    Percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass graft surgery (CABG) are each used to treat approximately 400,000 coronary artery disease patients annually in the United States...
  67. CORONARY ARTERY BYPASS ENDARTERECTOMY STAGING TRIAL
    John Ricotta; Fiscal Year: 2002
    ..From 5-12 percent of patients who present for Coronary Artery Bypass Grafting (CABG) will have significant stenosis at the carotid bifurcation...
  68. ASSESSING RISK FACTORS AND HOSPITAL QUALITY FOR CABG
    Edward Hannan; Fiscal Year: 1992
    ..are (1) to determine which preoperative risk factors are significantly related to the probability of a coronary artery bypass graft (CABG) patient experiencing an in-hospital mortality or perioperative complication, and (b) to use ..