cardiac surgical procedures

Summary

Summary: Surgery performed on the heart.

Top Publications

  1. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
  2. ncbi Acute kidney injury associated with cardiac surgery
    Mitchell H Rosner
    Division of Nephrology, Department of Internal Medicine, University of Virginia Health System, Box 800133, Charlottesville, VA 22908, USA
    Clin J Am Soc Nephrol 1:19-32. 2006
  3. ncbi European system for cardiac operative risk evaluation (EuroSCORE)
    S A Nashef
    Papworth Hospital, Cambridge, UK
    Eur J Cardiothorac Surg 16:9-13. 1999
  4. ncbi Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients
    F Roques
    Service de chirurgie cardiovasculaire, CHU de Fort de France, Martinique, France
    Eur J Cardiothorac Surg 15:816-22; discussion 822-3. 1999
  5. doi Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial
    Ludhmila A Hajjar
    Surgical Intensive Care Unit and Department of Anesthesiology, Heart Institute InCor, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    JAMA 304:1559-67. 2010
  6. pmc The development of cardiac surgery in West Africa--the case of Ghana
    Frank Edwin
    National Cardiothoracic Center, Korle Bu Teaching Hospital, P O Box KB 846, Accra, Ghana
    Pan Afr Med J 9:15. 2011
  7. pmc Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study
    Kathleen D Liu
    Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA, USA
    Crit Care 13:R104. 2009
  8. doi Risk factors for perioperative acute kidney injury after adult cardiac surgery: role of perioperative management
    Alessandro Parolari
    Department of Cardiovascular Sciences, Unit for Clinical Research in Atherothrombosis, Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy
    Ann Thorac Surg 93:584-91. 2012
  9. pmc Predicting acute kidney injury after cardiac surgery: a systematic review
    Sarah C Huen
    Department of Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Thorac Surg 93:337-47. 2012
  10. ncbi Inflammatory response to cardiopulmonary bypass
    Jerrold H Levy
    Department of Anesthesiology, Emory University School of Medicine, Division of Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, Georgia, USA
    Ann Thorac Surg 75:S715-20. 2003

Detail Information

Publications316 found, 100 shown here

  1. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
    ..We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for ischaemic renal injury after cardiopulmonary bypass...
  2. ncbi Acute kidney injury associated with cardiac surgery
    Mitchell H Rosner
    Division of Nephrology, Department of Internal Medicine, University of Virginia Health System, Box 800133, Charlottesville, VA 22908, USA
    Clin J Am Soc Nephrol 1:19-32. 2006
    ..Several compounds such as atrial natriuretic peptide and N-acetylcysteine have shown promise, but large-scale trials are needed...
  3. ncbi European system for cardiac operative risk evaluation (EuroSCORE)
    S A Nashef
    Papworth Hospital, Cambridge, UK
    Eur J Cardiothorac Surg 16:9-13. 1999
    ..To construct a scoring system for the prediction of early mortality in cardiac surgical patients in Europe on the basis of objective risk factors...
  4. ncbi Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients
    F Roques
    Service de chirurgie cardiovasculaire, CHU de Fort de France, Martinique, France
    Eur J Cardiothorac Surg 15:816-22; discussion 822-3. 1999
    ..To assess risk factors for mortality in cardiac surgical adult patients as part of a study to develop a European System for Cardiac Operative Risk Evaluation (EuroSCORE)...
  5. doi Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial
    Ludhmila A Hajjar
    Surgical Intensive Care Unit and Department of Anesthesiology, Heart Institute InCor, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    JAMA 304:1559-67. 2010
    ....
  6. pmc The development of cardiac surgery in West Africa--the case of Ghana
    Frank Edwin
    National Cardiothoracic Center, Korle Bu Teaching Hospital, P O Box KB 846, Accra, Ghana
    Pan Afr Med J 9:15. 2011
    ..It aims to dispel the notion that there are no major active cardiothoracic centers in the West African sub-region...
  7. pmc Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study
    Kathleen D Liu
    Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA, USA
    Crit Care 13:R104. 2009
    ..The purpose of this study was to test the role of serum cytokines as biomarkers for AKI and prolonged mechanical ventilation...
  8. doi Risk factors for perioperative acute kidney injury after adult cardiac surgery: role of perioperative management
    Alessandro Parolari
    Department of Cardiovascular Sciences, Unit for Clinical Research in Atherothrombosis, Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy
    Ann Thorac Surg 93:584-91. 2012
    ..Our aim was to assess the risk factors for postoperative AKI and whether the addition of perioperative management variables can improve AKI prediction...
  9. pmc Predicting acute kidney injury after cardiac surgery: a systematic review
    Sarah C Huen
    Department of Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Thorac Surg 93:337-47. 2012
    ..Standardizing risk factor and AKI definitions will facilitate the development and validation of risk models predicting AKI...
  10. ncbi Inflammatory response to cardiopulmonary bypass
    Jerrold H Levy
    Department of Anesthesiology, Emory University School of Medicine, Division of Cardiothoracic Anesthesiology and Critical Care, Emory Healthcare, Atlanta, Georgia, USA
    Ann Thorac Surg 75:S715-20. 2003
    ..Novel agents are under investigation to further improve outcomes in cardiac surgical patients...
  11. doi RIFLE criteria for cardiac surgery-associated acute kidney injury: risk factors and outcomes
    Augusto D'Onofrio
    Division of Cardiac Surgery, San Bortolo Hospital, Vicenza, Italy
    Congest Heart Fail 16:S32-6. 2010
    ..In conclusion, patients who develop CSA-AKI have a higher preoperative risk profile, more complex surgery, and worse clinical outcomes...
  12. doi Improvements in health-related quality of life before and after isolated cardiac operations
    Kathleen L Grady
    Division of Cardiac Surgery, Bluhm Cardiovascular Institute of Northwestern Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Thorac Surg 91:777-83. 2011
    ....
  13. doi Prediction models for prolonged intensive care unit stay after cardiac surgery: systematic review and validation study
    Roelof G A Ettema
    University of Applied Science Utrecht, Faculty of Health Care, Bolognalaan 101 3584 CJ Utrecht, Netherlands
    Circulation 122:682-9, 7 p following p 689. 2010
    ..However, no extensive quantitative validation of these models has yet been conducted. This study sought to identify and validate existing prediction models for prolonged ICU length of stay after cardiac surgery...
  14. doi Relationship of a common polymorphism of the glucocorticoid receptor gene to traumatic memories and posttraumatic stress disorder in patients after intensive care therapy
    Daniela Hauer
    Departments of Anaesthesiology, Ludwig Maximilians University, Munich, Germany
    Crit Care Med 39:643-50. 2011
    ....
  15. pmc Cardiac surgical experience in northern Nigeria
    J Nwiloh
    Section of Cardiothoracic Surgery, St Joseph s Hospital, Atlanta, GA, USA
    Cardiovasc J Afr 23:432-4. 2012
    ..This preliminary result has further stimulated the interest of all stakeholders on the urgency to establish open-heart surgery as part of the armamentarium to combat the ravages of heart diseases in northern Nigeria...
  16. pmc Treatment of gram-positive deep sternal wound infections in cardiac surgery--experiences with daptomycin
    Aron F Popov
    Department of Thoracic Cardiovascular Surgery, University of Gottingen, Germany
    J Cardiothorac Surg 6:112. 2011
    ..Based on these observations, daptomycin may offer a new treatment option for expediting surgical management of DSWI after cardiac surgery...
  17. doi Acute kidney injury after cardiac surgery: focus on modifiable risk factors
    Keyvan Karkouti
    Department of Anesthesia and Health Policy, Management, and Evaluation, Toronto General Hospital, University of Toronto, 200 Elizabeth St, EN 3 402, Toronto, Ontario, Canada M5G 2C4
    Circulation 119:495-502. 2009
    ..Lacking effective therapies, risk factor modification may offer a means of preventing this complication. The objective of the present study was to identify and determine the prognostic importance of such risk factors...
  18. pmc Wound complications after median sternotomy: a single-centre study
    Claudia Heilmann
    Department of Cardiovascular Surgery, Heart Center Freiburg University, Freiburg, Germany
    Interact Cardiovasc Thorac Surg 16:643-8. 2013
    ..Changes in both patient profile and type of operations have been observed in recent years. Therefore, we analysed current wound healing complications after median sternotomy at our centre...
  19. pmc Surgical treatment of cardiac hydatid disease in 13 patients
    Eylem Tuncer
    Department of Cardiovascular Surgery, Kosuyolu Heart and Research Hospital, 34846 Kartal, Istanbul, Turkey
    Tex Heart Inst J 37:189-93. 2010
    ..One patient experienced a recurrence 1 year postoperatively. We discuss our surgical approaches, the outcomes in our patients, and diagnostic and therapeutic recommendations...
  20. doi Aprotinin in cardiac surgery patients: is the risk worth the benefit?
    Sotiris C Stamou
    Department of Thoracic and Cardiovascular Surgery, Carolinas Heart and Vascular Institute, Carolinas Medical Center, Charlotte, NC 28203, USA
    Eur J Cardiothorac Surg 36:869-75. 2009
    ..Our study sought to compare the efficacy, early and late mortality and major morbidity associated with aprotinin compared with e-aminocaproic acid (EACA) in cardiac surgery operations...
  21. doi Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials
    Leanne Harling
    Department of Surgery and Cancer, Imperial College London, 10th Floor QEQM Building, St Mary s Hospital, London W2 1NY, UK
    Heart 97:1636-42. 2011
    ..This study aims to provide a quantitative summary of the current evidence surrounding antioxidant vitamins and POAF prevention...
  22. pmc Pharmacologic prophylaxis for atrial fibrillation following cardiac surgery: a systematic review
    Ioanna Koniari
    Cardiothoracic Surgery Department, Patras University, School of Medicine, Rion Patras, Greece
    J Cardiothorac Surg 5:121. 2010
    ....
  23. doi Relationship between exercise tolerance and muscle strength following cardiac rehabilitation: comparison of patients after cardiac surgery and patients with myocardial infarction
    Takahiro Sumide
    Juntendo Sports Clinic, Juntendo University Hospital, 3 1 3 Hongo, Bunkyo ku, Tokyo 113 8431, Japan
    J Cardiol 54:273-81. 2009
    ..The purpose of the present study was to assess the relationship between exercise tolerance and muscle strength following CR in patients after cardiac surgery and patients with MI...
  24. pmc The concept of negative pressure wound therapy (NPWT) after poststernotomy mediastinitis--a single center experience with 54 patients
    Ina C Ennker
    Mediclin Herzzentrum Lahr Baden, Abteilung Herzchirurgie, Hohbergweg 2, 77933 Lahr, Germany
    J Cardiothorac Surg 4:5. 2009
    ..We report about our experiences and complications using this therapy in a set of 54 patients out of 3668 patients undergoing cardiac surgery in our institution between January 2005 and April 2007...
  25. pmc Delirium: an independent predictor of functional decline after cardiac surgery
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts 02130, USA
    J Am Geriatr Soc 58:643-9. 2010
    ..To determine whether patients who developed delirium after cardiac surgery were at risk of functional decline...
  26. ncbi Prolonged intensive care unit stay in cardiac surgery: risk factors and long-term-survival
    Ortrud Vargas Hein
    Department of Anesthesiology and Intensive Care Medicine, Campus Charite Mitte, Charite University Medicine Berlin, Berlin, Germany
    Ann Thorac Surg 81:880-5. 2006
    ....
  27. ncbi EuroSCORE: a systematic review of international performance
    A Gogbashian
    The Royal College of Surgeons of England, 35 43 Lincoln s Inn Fields, London WC2A 3PN, UK
    Eur J Cardiothorac Surg 25:695-700. 2004
    ..Overall, however, EuroSCORE is the most rigorously evaluated scoring system in cardiac surgery...
  28. ncbi Coagulation disorders of cardiopulmonary bypass: a review
    Domenico Paparella
    Division of Cardiac Surgery, Dipartimento di Emergenza e Trapianti di Organo, University of Bari, Piazza Giulio Cesare 11, 70100 Bari, Italy
    Intensive Care Med 30:1873-81. 2004
    ..Postoperative bleeding is one of the most common complications of cardiac surgery...
  29. ncbi Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients
    Michael Haase
    Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
    Crit Care Med 35:1324-31. 2007
    ..To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure...
  30. ncbi Health-related quality of life and post-traumatic stress disorder in patients after cardiac surgery and intensive care treatment
    C Stoll
    Departments of Anaesthesiology, Cardiac Surgery, and Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Thorac Cardiovasc Surg 120:505-12. 2000
    ....
  31. ncbi Readmission to the intensive care unit after "fast-track" cardiac surgery: risk factors and outcomes
    Alexander Kogan
    Cardiothoracic Surgery, Rabin Medical Center, Beilinson Campus, Sackler School of Medicine, Tel Aviv University, Petah Tiqva, Israel
    Ann Thorac Surg 76:503-7. 2003
    ..Readmission to the ICU, traditionally used as a quality index, has not been investigated in these patients. The aim of this study was to assess the causes, risk factors, and outcomes associated with readmission to the ICU...
  32. ncbi Percutaneous versus surgical closure of secundum atrial septal defect: comparison of early results and complications
    Gianfranco Butera
    Pediatric Cardiology, Istituto Policlinico San Donato, San Donato Milanese MI, Italy
    Am Heart J 151:228-34. 2006
    ..Surgical closure of atrial septal defect (ASD) provides excellent results. Given the increasing popularity of percutaneous techniques, a comparison between the 2 methods is needed...
  33. doi Continuous mixed venous and central venous oxygen saturation in cardiac surgery with cardiopulmonary bypass
    Pierre Yves Lequeux
    Department of Anesthesiology, Intensive Care Unit, CHU Tivoli, La Louviere, Belgium
    Eur J Anaesthesiol 27:295-9. 2010
    ..The influence of surgery, cardiopulmonary bypass and anaesthesia drugs on the relationship between SvO2 and ScvO2 has never been studied...
  34. ncbi Pulmonary abnormalities after cardiac surgery are better explained by atelectasis than by increased permeability oedema
    J Verheij
    Department of Intensive Care, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Acta Anaesthesiol Scand 49:1302-10. 2005
    ..Cardiac surgery can be complicated by pulmonary abnormalities, but it is unclear how various manifestations interrelate...
  35. doi Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass
    Judith A Hudetz
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Administration Medical Center, Milwaukee, WI, USA
    J Cardiothorac Vasc Anesth 23:651-7. 2009
    ..To determine if ketamine attenuates postoperative delirium concomitant with an anti-inflammatory effect in patients undergoing cardiac surgery using cardiopulmonary bypass...
  36. doi Atrial fibrillation correction surgery: lessons from the Society of Thoracic Surgeons National Cardiac Database
    James S Gammie
    Division of Cardiac Surgery, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Ann Thorac Surg 85:909-14. 2008
    ..We also examined the subset of patients having mitral valve surgery to determine whether concurrent surgical AF correction procedures were associated with an increased risk of morbidity or mortality...
  37. ncbi Preoperative C-reactive protein predicts mid-term outcome after cardiac surgery
    Giangiuseppe Cappabianca
    Division of Cardiac Surgery, Dipartimento d Emergenza e Trapianti d Organo, University of Bari, Bari, Italy
    Ann Thorac Surg 82:2170-8. 2006
    ..The study objective was to evaluate the effect of CRP on short-term and mid-term outcome after cardiac surgery...
  38. doi Is right ventricular systolic function reduced after cardiac surgery? A two- and three-dimensional echocardiographic study
    Gloria Tamborini
    Centro Cardiologico Monzino, I R C C S, Institute of Cardiology, University of Milan, Via Parea 4, 20138 Milan, Italy
    Eur J Echocardiogr 10:630-4. 2009
    ..Aims of this study were to evaluate RV function in patients with mitral valve prolapse undergoing surgical valvular repair and to compare and correlate 3D RV ejection fraction (RVEF) with TAPSE and PSV before and after surgery...
  39. ncbi Guidelines for reporting data and outcomes for the surgical treatment of atrial fibrillation
    Richard J Shemin
    Division of Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Ann Thorac Surg 83:1225-30. 2007
    ..Thus, more reliable evaluation and comparisons of results will advance our knowledge and further the development and application of these procedures...
  40. ncbi Long-term effects of surgical septal myectomy on survival in patients with obstructive hypertrophic cardiomyopathy
    Steve R Ommen
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 46:470-6. 2005
    ..This study sought to determine the impact of surgical myectomy on long-term survival in hypertrophic cardiomyopathy (HCM)...
  41. ncbi Postoperative atrial fibrillation is not correlated to C-reactive protein
    Anders J Ahlsson
    Department of Cardiothoracic Surgery and Anesthesiology, Orebro University Hospital, Orebro, Sweden
    Ann Thorac Surg 83:1332-7. 2007
    ..The aim of this study was to investigate differences between patients with and without postoperative AF with special regard to C-reactive protein (CRP) serum levels...
  42. doi The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Blood 117:4218-25. 2011
    ..In conclusion, the incidence of TRALI is high in cardiac surgery patients and associated with adverse outcome. Our results suggest that cardiac surgery patients may benefit from exclusion of blood products containing HLA/HNA antibodies...
  43. ncbi Late complications in patients after repair of aortic coarctation: implications for management
    Joris W J Vriend
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Cardiol 101:399-406. 2005
    ..In this review, these complications, with particular reference to late hypertension, are discussed and strategies for the clinical management of post-coarctectomy patients are described...
  44. ncbi Risk adjustment for congenital heart surgery: the RACHS-1 method
    Kathy J Jenkins
    Department of Cardiology, Children s Hospital, Boston, MA, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 7:180-4. 2004
    ..Underlying assumptions about RACHS-1 risk categories, inclusion and exclusion criteria, and appropriate and inappropriate uses are discussed...
  45. ncbi Epidemiology, mechanisms, and risks: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery
    Charles W Hogue
    Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Ave, Box 8054, St Louis, MO 63110, USA
    Chest 128:9S-16S. 2005
    ....
  46. ncbi Postoperative mediastinitis in cardiac surgery - microbiology and pathogenesis
    B Gardlund
    Department of Infectious Diseases, Karolinska Hospital, Stockholm, Sweden
    Eur J Cardiothorac Surg 21:825-30. 2002
    ..32%) of 9557 consecutive cardiac surgery procedures. The study was done to describe the variation in clinical characteristics and microbiological etiology in mediastinitis...
  47. ncbi Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery
    S R Leal-Noval
    Critical Care Division, Hospital Universitario Virgen del Rocio, Seville, Spain
    Chest 119:1461-8. 2001
    ..To investigate the influence of blood derivatives on the acquisition of severe postoperative infection (SPI) in patients undergoing heart surgery...
  48. doi Cardiac surgery-associated acute kidney injury: a comparison of two consensus criteria
    Alina M Robert
    Internal Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Ann Thorac Surg 90:1939-43. 2010
    ..We sought to estimate the ability of both the RIFLE and and AKIN criteria to predict the risk of in-hospital mortality in the setting of cardiac surgery...
  49. ncbi A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery
    R C Gallandat Huet
    Department of Anesthesiology, University Hospital Groningen, The Netherlands
    Can J Anaesth 47:1207-15. 2000
    ..To compare the new hydroxyethyl starch HES 130/0.4 (Voluven) and the standard HES 200/0.5 (pentastarch) regarding effectiveness for plasma volume substitution and safety of large volumes in heart surgery...
  50. ncbi Hemodynamic effects of vacuum-assisted closure therapy in cardiac surgery: assessment using magnetic resonance imaging
    Rainer Petzina
    Department of Medicine, Lund University Hospital, Lund, Sweden
    J Thorac Cardiovasc Surg 133:1154-62. 2007
    ....
  51. pmc Open heart surgery in Nigeria; a work in progress
    Bode Falase
    Cardiothoracic Division, Lagos State University College of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria
    J Cardiothorac Surg 8:6. 2013
    ..The aim of this study is to review the experience with Open Heart Surgery at the Lagos State University Teaching Hospital and highlight the challenges encountered in developing this programme...
  52. doi Cognitive function after sevoflurane- vs propofol-based anaesthesia for on-pump cardiac surgery: a randomized controlled trial
    J Schoen
    Department of Anesthesiology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Br J Anaesth 106:840-50. 2011
    ..This study was designed to determine cognitive and clinical outcomes after sevoflurane- compared with propofol-based anaesthesia for on-pump cardiac surgery and the impact of decreases in under different anaesthesia regimens...
  53. pmc N-3 polyunsaturated fatty acids to prevent atrial fibrillation: updated systematic review and meta-analysis of randomized controlled trials
    Javier Mariani
    Fundación GESICA Grupo de Estudio de Investigación Clínica en Argentina, Buenos Aires, Argentina
    J Am Heart Assoc 2:e005033. 2013
    ..We aimed to assess the effects of therapy with n-3 PUFAs on the incidence of recurrent AF and on postoperative AF...
  54. doi Hybrid procedures: adverse events and procedural characteristics--results of a multi-institutional registry
    Ralf Holzer
    Department of Cardiology, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Congenit Heart Dis 5:233-42. 2010
    ....
  55. doi Risk factors for nonocclusive mesenteric ischemia after elective cardiac surgery
    Heinrich Volker Groesdonk
    Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg Saar, Germany
    J Thorac Cardiovasc Surg 145:1603-10. 2013
    ..It is crucial to early identify patients who are at risk of developing this complication. The aim of this prospective study was to evaluate perioperative risk factors in a large cohort of patients undergoing elective cardiac surgery...
  56. doi Update on acute kidney injury after cardiac surgery
    Andrew Shaw
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 143:676-81. 2012
    ..To review the current state of clinical practice and discuss recent advances in the diagnosis and management of acute kidney injury (AKI) in the context of cardiac surgery...
  57. pmc Daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgery
    Florian Weis
    Department of Anaesthesiology, University of Munich LMU, Marchioninistrasse 15, 81377, Munich, Germany
    J Cardiothorac Surg 7:81. 2012
    ..Within this study, we report the successful use of daptomycin as supportive therapy in patients developing mediastinitis after open cardiac surgery...
  58. doi The association of preoperative glycemic control, intraoperative insulin sensitivity, and outcomes after cardiac surgery
    Hiroaki Sato
    Department of Anaesthesia, Royal Victoria Hospital, McGill University Health Center, Montreal, Quebec, Canada H3A 1A1
    J Clin Endocrinol Metab 95:4338-44. 2010
    ..The impairment of insulin sensitivity, a marker of surgical stress, is important for outcomes...
  59. pmc Treatment outcomes of postoperative mediastinitis in cardiac surgery; negative pressure wound therapy versus conventional treatment
    Hayati Deniz
    Gaziantep University Medical Faculty, Department of Cardiovascular Surgery, Sehitkamil, Gaziantep, Turkey
    J Cardiothorac Surg 7:67. 2012
    ..The aim of the present study is to compare negative pressure wound therapy versus conventional treatment outcomes at postoperative mediastinitis after cardiac surgery...
  60. pmc Outcome and survival analysis of intestinal ischaemia following cardiac surgery
    Philip Y K Pang
    Department of Cardiothoracic Surgery, National Heart Centre, Singapore, Singapore
    Interact Cardiovasc Thorac Surg 15:215-8. 2012
    ..The purpose of this study was to analyse the outcomes and prognostic factors in patients who develop intestinal ischaemia following cardiac surgery...
  61. doi The effect of blood transfusion on pulmonary permeability in cardiac surgery patients: a prospective multicenter cohort study
    Alexander P J Vlaar
    Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Transfusion 52:82-90. 2012
    ..Mediators of increased pulmonary vascular leakage after transfusion are unknown. We hypothesized that factors may include antibodies or bioactive lipids, which have been implicated in transfusion-related acute lung injury...
  62. ncbi The pathophysiology of cardiac surgery-associated acute kidney injury (CSA-AKI)
    R Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Int J Artif Organs 31:166-78. 2008
    ..The administration of N-acetylcysteine to protect the kidney from oxidative stress is not recommended. There is marked lack of randomised controlled trials in this field...
  63. pmc Gastrointestinal complications in patients undergoing heart operation: an analysis of 8709 consecutive cardiac surgical patients
    Abeel A Mangi
    Division of General and Gastrointestinal Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Surg 241:895-901; discussion 901-4. 2005
    ..Systematic analysis of risk factors to allow early identification of patients at risk for GI complication may lead to the development of strategies to mitigate this complication as well as to optimize management after its occurrence...
  64. doi Myocardial Assistance by Grafting a New Bioartificial Upgraded Myocardium (MAGNUM trial): clinical feasibility study
    Juan C Chachques
    Department of Cardiovascular Surgery, Pompidou Hospital, Paris, France
    Ann Thorac Surg 85:901-8. 2008
    ..We evaluated the feasibility and safety of intrainfarct cell therapy associated with a cell-seeded collagen scaffold grafted onto infarcted ventricles...
  65. ncbi Postoperative white blood cell count predicts atrial fibrillation after cardiac surgery
    Gudrun Lamm
    Department of Cardiology and Intensive Care, General Hospital Wels, Wels, Austria
    J Cardiothorac Vasc Anesth 20:51-6. 2006
    ..The purpose of the present study was to investigate the correlation between the postoperative white blood cell (WBC) count as a marker of inflammation and the development of postoperative AF after cardiac surgery...
  66. doi Acute hemodynamic effects of cardiac resynchronization therapy in patients with poor left ventricular function during cardiac surgery
    Mohamed A Soliman Hamad
    Department of Cardiothoracic Surgery, Catharina Hospital, Eindhoven, The Netherlands
    J Card Surg 24:585-90. 2009
    ..We investigated the acute hemodynamic response using LVdP/dt(max) in patients with depressed LV function and conduction disturbances undergoing cardiac surgery...
  67. pmc Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the Pediatric Health Information Systems database
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 122:2123-30. 2010
    ..Children undergoing congenital heart surgery often receive corticosteroids with the aim of reducing the inflammatory response after cardiopulmonary bypass; however, the value of this approach is unclear...
  68. doi Cross-clamp time is an independent predictor of mortality and morbidity in low- and high-risk cardiac patients
    Nael Al-Sarraf
    Department of Cardiothoracic Surgery, St James s Hospital, Dublin 8, Ireland
    Int J Surg 9:104-9. 2011
    ..We sought to assess the effects of aortic cross-clamp time (XCL) on outcome following cardiac surgery in low- and high-risk patients...
  69. doi Changing from aprotinin to tranexamic acid results in increased use of blood products and recombinant factor VIIa for aortic surgery requiring hypothermic arrest
    Roman M Sniecinski
    Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cardiothorac Vasc Anesth 24:959-63. 2010
    ..This study was undertaken to determine what, if any, the impact of changing antifibrinolytic agents (from aprotinin to tranexamic acid) for deep hypothermic circulatory arrest cases would have on blood bank resource utilization...
  70. pmc Major infection after pediatric cardiac surgery: a risk estimation model
    Gregory M Barker
    Duke University Medical Center, Durham, North Carolina, USA
    Ann Thorac Surg 89:843-50. 2010
    ..In pediatric cardiac surgery, infection is a leading cause of morbidity and mortality. We created a model to predict risk of major infection in this population...
  71. doi Mild-to-moderate COPD as a risk factor for increased 30-day mortality in cardiac surgery
    M Ried
    Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany
    Thorac Cardiovasc Surg 58:387-91. 2010
    ..Chronic obstructive pulmonary disease (COPD) is still a serious comorbidity in surgical procedures. We assessed the impact of mild to moderate COPD in a modern cardiac surgery unit...
  72. doi Left atrial radiofrequency ablation during mitral valve surgery: a prospective randomized multicentre study (SAFIR)
    Philippe Chevalier
    Department of Cardiology Rythmology, Hospices Civils de Lyon, Hopital Cardiologique Louis Pradel, CHU Louis Pradel, avenue du doyen Lepine, Lyon Cedex 03, France
    Arch Cardiovasc Dis 102:769-75. 2009
    ..Randomized studies evaluating left atrial radiofrequency ablation (RFA) in patients with persistent atrial fibrillation undergoing mitral valve surgery are scarce and monocentric...
  73. doi Management of intraoperative fluid balance and blood conservation techniques in adult cardiac surgery
    George Vretzakis
    Cardiac Anaesthesia Unit, University Hospital of Larissa, Greece
    Heart Surg Forum 14:E28-39. 2011
    ....
  74. doi Vacuum-assisted wound closure is superior to primary rewiring in patients with deep sternal wound infection
    A Assmann
    Department of Cardiovascular Surgery, University Hospital, Duesseldorf, Germany
    Thorac Cardiovasc Surg 59:25-9. 2011
    ..The study additionally focuses on defining predictors for the failure of primary rewiring and its impact on postoperative outcome...
  75. doi Prevention of atrial fibrillation in cardiac surgery: time to consider a multimodality pharmacological approach
    Kwok M Ho
    Department of Intensive Care Medicine, Royal Perth Hospital and School of Population Health, University of Western Australia, Perth, WA 6000, Australia
    Cardiovasc Ther 28:59-65. 2010
    ..Randomized controlled trials evaluating the effectiveness of a multimodality pharmacological approach in patients at high-risk of AF after cardiac surgery are needed...
  76. pmc Cardiovascular magnetic resonance and PET-CT of left atrial paraganglioma
    Anderanik Tomasian
    Department of Radiological Sciences, University of California at Los Angeles, USA
    J Cardiovasc Magn Reson 12:1. 2010
    ....
  77. doi Prevalence of left ventricular systolic dysfunction in adults with repaired tetralogy of fallot
    Craig S Broberg
    Oregon Health and Science University, Portland, Oregon
    Am J Cardiol 107:1215-20. 2011
    ..Severity or duration of pulmonary regurgitation was not different. In conclusion, LV systolic dysfunction was found in 21% of adult patients with TOF and was associated with shunt duration, RV dysfunction, and arrhythmia...
  78. doi Improved outcomes associated with intraoperative steroid use in high-risk pediatric cardiac surgery
    Nadia A Clarizia
    The Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 91:1222-7. 2011
    ..Corticosteroids are commonly administered perioperatively in pediatric cardiac surgery to reduce cardiopulmonary bypass induced inflammation. However, their effects on outcomes and potential for adverse events are not well defined...
  79. ncbi Increased central aortic stiffness and left ventricular mass in normotensive young subjects after successful coarctation repair
    Phalla Ou
    Department of Pediatric Radiology, Hopital Necker Enfants Malades, University Rene Descartes Paris 5, Paris, France
    Am Heart J 155:187-93. 2008
    ..Hypertension occurs in 20% to 40% of survivors of anatomically successful repair of aortic coarctation (CoA). The aim of the present study was to examine the role of central aortic function in this setting...
  80. doi Minimally invasive perventricular device closure of an isolated perimembranous ventricular septal defect with a newly designed delivery system: preliminary experience
    Xing Quansheng
    Pediatric Cardiovascular Centre, Qingdao Children s Hospital, Qingdao, China
    J Thorac Cardiovasc Surg 137:556-9. 2009
    ..We sought to summarize the preliminary clinical experience of minimally invasive transthoracic device closure of perimembranous ventricular septal defects with a new delivery system without cardiopulmonary bypass...
  81. doi Intraoperative device closure of doubly committed subarterial ventricular septal defects: initial experience
    Qiang Chen
    Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, People s Republic of China
    Ann Thorac Surg 90:869-73. 2010
    ..The purpose of this study was to evaluate the safety and feasibility of intraoperative device closure of the doubly committed subarterial ventricular septal defect (VSD)...
  82. doi A comparison of aprotinin and lysine analogues in high-risk cardiac surgery
    Dean A Fergusson
    Ottawa Health Research Institute, Ottawa, Canada
    N Engl J Med 358:2319-31. 2008
    ..We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences...
  83. doi Impact of postoperative hyperglycemia following surgical repair of congenital cardiac defects
    Germano Falcao
    Department of Pediatrics, Driscoll Children s Hospital, Corpus Christi, TX 78411, USA
    Pediatr Cardiol 29:628-36. 2008
    ..Hyperglycemia is common in children following surgical repair or palliation of congenital cardiac defects. Postoperative hyperglycemia is associated with increased morbidity and mortality in these patients...
  84. doi Impact of stroke on therapeutic decision making in infective endocarditis
    Laurent Derex
    Unité de Soins Intensifs Neurovasculaires, Department of Neurology, Hopital Neurologique, University of Lyon, 59 Boulevard Pinel, 69003, Lyon, France
    J Neurol 257:315-21. 2010
    ..Early surgery appears safe in patients presenting transient ischemic attacks or "silent" cerebral embolism...
  85. pmc Association between intraoperative and early postoperative glucose levels and adverse outcomes after complex congenital heart surgery
    Angelo Polito
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Circulation 118:2235-42. 2008
    ..This study sought to determine whether associations exist between perioperative glucose exposure, prolonged hospitalization, and morbid events after complex congenital heart surgery...
  86. ncbi The impact of nosocomial infections on patient outcomes following cardiac surgery
    M H Kollef
    Department of Internal Medicine, Pulmonary and Critical Care, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 112:666-75. 1997
    ..To evaluate the relationship between nosocomial infections and clinical outcomes following cardiac surgery, and to identify risk factors for the development of nosocomial infections in this patient population...
  87. ncbi Aortic arch shape deformation after coarctation surgery: effect on blood pressure response
    Phalla Ou
    INSERM UMR_S678, Faculté de Médecine Pitié Salpêtrière, Paris, France
    J Thorac Cardiovasc Surg 132:1105-11. 2006
    ..We sought to investigate the effect of particular deformations of aortic arch shape on blood pressure response in children who had undergone successful repair of coarctation of the aorta...
  88. ncbi Interleukin-10 and its role in clinical immunoparalysis following pediatric cardiac surgery
    Meredith L Allen
    Critical Care Group Portex Unit, Institute of Child Health, University College London, UK
    Crit Care Med 34:2658-65. 2006
    ....
  89. doi Tetralogy of fallot: yesterday and today
    Joanne P Starr
    Department of Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ, 07103, USA
    World J Surg 34:658-68. 2010
    ..This article presents a review of TOF, including the history of surgical treatment, present-day approaches, and long-term outcomes...
  90. ncbi Postoperative cognitive dysfunction after cardiac surgery
    Lan Gao
    Laboratory of Anesthesia, Department of Anesthesia and Research Centre, Centre Hospitalier de l University de Montreal, Hospital Notre Dame, QC, Canada
    Chest 128:3664-70. 2005
    ..The purpose of this review is to discuss recent developments in our understanding of the pathophysiologic mechanisms, prevention, and treatments that have been designed to ameliorate brain dysfunction after cardiac surgery...
  91. doi A small post-operative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery
    Michael Zappitelli
    Department of Pediatrics, McGill University Health Centre, Montreal Children s Hospital, Quebec, Canada
    Kidney Int 76:885-92. 2009
    ..65). Our study shows that AKI after pediatric heart surgery is common and is a risk factor for poorer outcome. Small post-operative increases in serum creatinine may assist in the early prediction of AKI...
  92. ncbi [Nosocomial infections in pediatric patients following cardiac surgery]
    M T Guardia Camí
    Servicio de Pediatria, Unidad Integrada Hospital Sant Joan de Déu Hospital Clínic i Provincial de Barcelona, Barcelona, Spain
    An Pediatr (Barc) 69:34-8. 2008
    ..This study was undertaken to determine the NI rate, main risk factors, and microbial spectrum in a paediatric intensive care unit (PICU) for this group of patients...
  93. ncbi Primary cardiac tumours: eighteen years of surgical experience on 21 patients
    Nicolo Piazza
    McGill University, 3755 Cote Ste Catherine Road, Montreal, Quebec H3T 1E2, Canada
    Can J Cardiol 20:1443-8. 2004
    ..The literature on primary cardiac tumours is relatively limited because of their rare occurrence...
  94. ncbi Does the choice of risk-adjustment model influence the outcome of surgeon-specific mortality analysis? A retrospective analysis of 14,637 patients under 31 surgeons
    S W Grant
    University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester M23 9LT, UK
    Heart 94:1044-9. 2008
    ..To compare implications of using the logistic EuroSCORE and a locally derived model when analysing individual surgeon mortality outcomes...
  95. doi Preoperative cerebral oxygen saturation and clinical outcomes in cardiac surgery
    Matthias Heringlake
    Cardiac Anesthesia Unit, Department of Anesthesiology, University of Lubeck, Lubeck, Germany
    Anesthesiology 114:58-69. 2011
    ..The current study was designed to determine the relation between preoperative cerebral oxygen saturation (Sco2), variables of cardiopulmonary function, mortality, and morbidity in a heterogeneous cohort of cardiac surgery patients...
  96. ncbi Clinical management of infants with hypoplastic left heart syndrome in the United States, 1988-1997
    Ruey Kang R Chang
    Division of Cardiology, Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Pediatrics 110:292-8. 2002
    ..To evaluate changes in the clinical management of infants with hypoplastic left heart syndrome (HLHS) over a 10-year period...
  97. doi Deep sternal wound infections following open heart surgery in Iceland: a population-based study
    Steinn Steingrimsson
    Department of Cardiothoracic Surgery, Landspitali University Hospital, Reykjavik, Iceland
    Scand Cardiovasc J 42:208-13. 2008
    ..The aim of this nationwide case-control study was to study the epidemiology and identify risk factors of deep sternal wound infections (DSWI) in Iceland...
  98. doi Errors and the burden of errors: attitudes, perceptions, and the culture of safety in pediatric cardiac surgical teams
    Agnes Bognar
    Department of Ophthalmology, School of Medicine, University of Szeged, Szeged, Hungary
    Ann Thorac Surg 85:1374-81. 2008
    ..We assessed the perceptions and attitudes of surgical teams relative to committing errors, the impact of errors, and the culture of safety...
  99. doi Temporary biventricular pacing postcardiopulmonary bypass in patients with reduced ejection fraction
    Jochen D Muehlschlegel
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Card Surg 23:324-30. 2008
    ..This study analyzed the response of BiV versus single ventricle lead pacing on hemodynamics and left ventricular (LV) function immediately following CPB...
  100. doi Myths about surgical myectomy: rumors of its death have been greatly exaggerated
    Barry J Maron
    Am J Cardiol 101:887-9. 2008
  101. ncbi Nosocomial infections in pediatric cardiac surgery, Italy
    M Valera
    Department of Immuno-Infectivology, University of Turin, Italy
    Infect Control Hosp Epidemiol 22:771-5. 2001
    ..The higher NI incidence in patients with an open chest postoperatively suggests that an alternative antibiotic strategy should be considered for these patients...

Research Grants40

  1. Development of a Surgical and Transcatheter Polymeric Heart Valve
    JACK CABELL GRIFFIS; Fiscal Year: 2012
    ..In this application, we propose the development and testing of a novel polymeric heart valve, prepared from a resilient, highly durable material with exquisite shape memory properties. ..
  2. CLINICAL LEFT VENTRICULAR BYPASS STUDIES
    WILLIAM BERNHARD; Fiscal Year: 1980
    ..They will include those who cannot be adequately resuscitated at the end of a cardiac surgical operation, and others who develop cardiogenic shock within 72 hours following an uncomplicated cardiac surgical procedure. ..
  3. Stroke Prevention Through Atrial Appendage Occlusion
    JON SHERMAN; Fiscal Year: 2005
    ..Phase II will focus on adapting the canine design for use in humans. ..
  4. High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac Surgery
    Dean Andropoulos; Fiscal Year: 2008
    ..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..
  5. Long-term White Matter Changes Resulting from Delirium after Surgery
    James Rudolph; Fiscal Year: 2008
    ..If the hypotheses are confirmed, this will alter our fundamental understanding of delirium as a short-term disorder and future studies can use imaging to prevent, identify, and treat delirium. [unreadable] [unreadable] [unreadable]..
  6. Estradiol For Neurocognitive Dysfunction After CABG
    Charles Hogue; Fiscal Year: 2005
    ..The results of this study will evaluate the efficacy and safety of an easily implemented therapy for improving neurologic outcome and quality of life after CABG surgery for postmenopausal women. ..
  7. Modified Late Infarct Reperfusion to Prevent Post MI CHF
    Robert Gorman; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. STICH Trial Radionuclide Core Laboratory
    Robert Bonow; Fiscal Year: 2007
    ..abstract_text> ..
  10. Cardiac Parasympathetic Effect in Exercise and Recovery
    Jeffrey Goldberger; Fiscal Year: 2006
    ..abstract_text> ..
  11. Logical Analysis of Data and Cardiac Surgery Risk
    Eugene Blackstone; Fiscal Year: 2006
    ..Hence, the applicability of this work goes beyond determination of risk of patients undergoing cardiac surgery. ..
  12. MECHANISMS OF COMPLEMENT INDUCED MYOCARDIAL ISCHEMIA
    GREGORY STAHL; Fiscal Year: 2007
    ..abstract_text> ..
  13. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  14. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2008
    ..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
  15. Enhancing Recovery After Cardiac Surgery
    Lynn Doering; Fiscal Year: 2008
    ..abstract_text> ..
  16. Interdisciplinary Training: Neurodevelopmental Toxicology(RMI)
    David Bellinger; Fiscal Year: 2008
    ..Members of the faculty currently conduct a wealth of multidisciplinary research, which will provide trainees with ready opportunities to apply their training in ongoing research projects. [unreadable] [unreadable]..
  17. Vessel Remodeling During Ductus Arteriosus Closure
    Ronald I Clyman; Fiscal Year: 2010
    ..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..
  18. Strain Controlled LVAD Unloading and Post MI Remodeling
    BARTLEY PERRY GRIFFITH; Fiscal Year: 2010
    ..Accordingly, we will learn the impact of controlled strain after large infarction with an interventionally applied micro VAD. ..
  19. Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
    Mias Pretorius; Fiscal Year: 2010
    ..These studies promise to provide important information regarding the effects of drugs that interrupt the RAS and generate new strategies to reduce morbidity in patients undergoing CPB. ..
  20. DEVELOPMENT OF A CHRONIC ARTIFICIAL LUNG
    Bartley Griffith; Fiscal Year: 2001
    ..5) Develop and validate a closed-loop, flow control algorithm to ensure fail-safe pumping by the CAL spinning disc(s); incorporate algorithm into a controller unit to be part of the overall CAL system. ..
  21. QUALITY OF LIFE OUTCOMES >= 5 YRS POST HEART TRANSPLANT
    Kathleen Grady; Fiscal Year: 2004
    ..Health-Related Implications. These data will provide information regarding (1) long-term benefits versus risks of HT, (2) patients at risk for poor outcomes, (3) and targets for interventions to improve outcomes. ..
  22. BIOENGINEERING-BIOLOGIC STUDY OF NON-PULSATILE PERFUSION
    Bartley Griffith; Fiscal Year: 2002
    ..From these experiments, we believe that we will provide significant new information regarding tissue perfusion and arterial adaptation to, and possible impairment from, diminished or non-existent flow pulse. ..
  23. INNATE IMMUNITY AND MYOCARDIAL INJURY
    GREGORY STAHL; Fiscal Year: 2003
    ..abstract_text> ..
  24. Controlled Reperfusion for Whole Body Ischemic Injury
    Gerald Buckberg; Fiscal Year: 2005
    ..If this novel method of management is correct, the scheme of diagnosis and management of this almost always fatal cardiac arrest complex will change markedly. ..
  25. VENTRICULAR FUNCTION DURING CARDIAC SURGERY
    HENRY SPOTNITZ; Fiscal Year: 2005
    ....
  26. BIOENGINEERING-BIOLOGIC STUDY OF NON-PULSATILE PERFUSION
    Bartley Griffith; Fiscal Year: 2003
    ..From these experiments, we believe that we will provide significant new information regarding tissue perfusion and arterial adaptation to, and possible impairment from, diminished or non-existent flow pulse. ..
  27. The Effect of cGMP on Pulmonary Endothelial Apoptosis
    Robert Stephens; Fiscal Year: 2008
    ..An understanding of how this phenomenon is regulated in acute lung injury may lead to new therapies for this severe illness. [unreadable] [unreadable] [unreadable] [unreadable]..
  28. SEVERE DEPRESSION IN WOMEN AFTER CARDIAC SURGERY
    Lynn Doering; Fiscal Year: 2002
    ..The research proposed as part of the award is designed to completed the applicant's formal and laboratory training. ..
  29. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2005
    ..abstract_text> ..
  30. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
    ..The final phase will study mechanisms of vascular protection afforded by aprotinin. The proposed study has the potential to reduce the risk of brain injury in children and adults undergoing heart surgery. ..
  31. Bacteremia from Dental Extraction vs. Oral Hygiene
    Peter Lockhart; Fiscal Year: 2004
    ..Additionally, we will have unique and critical data for the development of both future research and evidence-based guidelines concerning antibiotic prophylaxis for individuals currently felt to be at risk for DSI. ..
  32. Retrograde In Situ Isolated Cardiac Gene Delivery
    Charles Bridges; Fiscal Year: 2004
    ..Further development of this approach may ultimately lead to the development of clinically relevant techniques of therapeutic cardiac gene delivery for the treatment of heart failure of diverse etiologies. ..
  33. Quality Improvement and Outcomes for Strokes After CABG
    DONALD LIKOSKY; Fiscal Year: 2004
    ..abstract_text> ..
  34. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  35. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  36. Robotically Assisted Mouse Interventions
    Kevin Cleary; Fiscal Year: 2008
    ..3. Perform a feasibility study using 10 mice to demonstrate the ability of the robot to biopsy the mouse flank as selected on the MRI images and evaluate the accuracy of the system. [unreadable] [unreadable] [unreadable]..
  37. OR2020 Workshop: Operating Room of the Future
    Kevin Cleary; Fiscal Year: 2004
    ..The workshop is currently scheduled to be held from April 16-17, 2004, at Turf Valley Conference Center in Ellicot City, Maryland. ..
  38. Software Toolkit for Image Guided Surgery
    Kevin Cleary; Fiscal Year: 2005
    ..Dissemination activities will be undertaken with the aim of fostering the use of the toolkit in research and clinical applications. ..
  39. Continued Development for The Image-guided Surgical Toolkit Project (IGSTK)
    Kevin Cleary; Fiscal Year: 2009
    ....
  40. CT fluoroscopy guided robotically assisted lung biopsy
    Kevin Cleary; Fiscal Year: 2005
    ..The system will be validated in phantom and animal studies. The R33 phase will result in a system that is ready for clinical trials. ..