needle biopsy

Summary

Summary: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.

Top Publications

  1. ncbi Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
    Arie Regev
    Division of Hepatology, Center for Liver Diseases, University of Miami School of Medicine, Florida 33136, USA
    Am J Gastroenterol 97:2614-8. 2002
  2. ncbi Role of ultrasound-guided fine-needle aspiration of indeterminate and suspicious axillary lymph nodes in the initial staging of breast carcinoma
    Savitri Krishnamurthy
    Department of Pathology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 95:982-8. 2002
  3. ncbi CT-guided needle biopsy of lung lesions: a survey of severe complication based on 9783 biopsies in Japan
    Noriyuki Tomiyama
    Department of Radiology, Osaka University Graduated School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Eur J Radiol 59:60-4. 2006
  4. ncbi Sonographically guided core needle biopsy of cervical lymphadenopathy in patients without known malignancy
    Byung Moon Kim
    Department of Diagnostic Radiology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea
    J Ultrasound Med 26:585-91. 2007
  5. ncbi Risk management of renal biopsy: 1387 cases over 30 years in a single centre
    P Stratta
    Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Maggiore Hospital, Novara, Italy
    Eur J Clin Invest 37:954-63. 2007
  6. ncbi The percutaneous needle biopsy is safe and recommended in the diagnosis of musculoskeletal masses
    J A Welker
    Washington Cancer Institute, Washington, District of Columbia 20010, USA
    Cancer 89:2677-86. 2000
  7. pmc Four cases of a cerebral air embolism complicating a percutaneous transthoracic needle biopsy
    Soo Jung Um
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
    Korean J Radiol 10:81-4. 2009
  8. ncbi Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the disease
    Guido Colloredo
    Liver Unit, Seriate Hospital, Bergamo, Italy
    J Hepatol 39:239-44. 2003
  9. doi Personalized prediction of tumor response and cancer progression on prostate needle biopsy
    Michael J Donovan
    Aureon Laboratories, Inc, New York, New York 10701, USA
    J Urol 182:125-32. 2009
  10. ncbi Bronchoscopy and needle biopsy techniques for diagnosis and staging of lung cancer
    Peter Mazzone
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Chest Med 23:137-58, ix. 2002

Research Grants

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  2. Robot-Assisted MRI-Guided Prostate Biopsy
    Dan Stoianovici; Fiscal Year: 2010
  3. A Molecular targeting agent for systemic radiotherapy of metastatic Prostate Canc
    Kevin P Maresca; Fiscal Year: 2010
  4. Development of high-throughput, commercially viable, Cell-CT instrument with init
    Thomas Neumann; Fiscal Year: 2010
  5. Zinc-Based Early Detection of Prostate Cancer
    Christopher J Frederickson; Fiscal Year: 2010
  6. Metabolomic Markers for Early Detection of Prostate Cancer
    Arun Sreekumar; Fiscal Year: 2010
  7. Leucine Type Amino Acid Transport In Gliomas
    MARK MYRON GOODMAN; Fiscal Year: 2012
  8. Sebastiano Gattoni-Celli; Fiscal Year: 2016
  9. Exercise adaptations in mitochondrial myopathy: therapeutic implications
    Ronald G Haller; Fiscal Year: 2012
  10. Ron Alterovitz; Fiscal Year: 2014

Detail Information

Publications359 found, 100 shown here

  1. ncbi Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
    Arie Regev
    Division of Hepatology, Center for Liver Diseases, University of Miami School of Medicine, Florida 33136, USA
    Am J Gastroenterol 97:2614-8. 2002
    ....
  2. ncbi Role of ultrasound-guided fine-needle aspiration of indeterminate and suspicious axillary lymph nodes in the initial staging of breast carcinoma
    Savitri Krishnamurthy
    Department of Pathology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 95:982-8. 2002
    ..This study was undertaken to determine the diagnostic accuracy of US-guided FNA of indeterminate/suspicious/metastatic-appearing axillary lymph nodes during the initial staging of breast carcinoma...
  3. ncbi CT-guided needle biopsy of lung lesions: a survey of severe complication based on 9783 biopsies in Japan
    Noriyuki Tomiyama
    Department of Radiology, Osaka University Graduated School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Eur J Radiol 59:60-4. 2006
    The aim of our study was to update the rate of severe complications following CT-guided needle biopsy in Japan via a mailed survey.
  4. ncbi Sonographically guided core needle biopsy of cervical lymphadenopathy in patients without known malignancy
    Byung Moon Kim
    Department of Diagnostic Radiology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea
    J Ultrasound Med 26:585-91. 2007
    The purpose of this study was to retrospectively evaluate the efficacy of sonographically guided core needle biopsy (core biopsy) for diagnosing the causes of cervical lymphadenopathy in patients without known malignancy.
  5. ncbi Risk management of renal biopsy: 1387 cases over 30 years in a single centre
    P Stratta
    Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Maggiore Hospital, Novara, Italy
    Eur J Clin Invest 37:954-63. 2007
    ..We aimed to obtain a comprehensive assessment of safety/utility ratio of percutaneous renal biopsy...
  6. ncbi The percutaneous needle biopsy is safe and recommended in the diagnosis of musculoskeletal masses
    J A Welker
    Washington Cancer Institute, Washington, District of Columbia 20010, USA
    Cancer 89:2677-86. 2000
    The purpose of this study was to analyze the role of percutaneous core needle biopsy in the diagnosis of musculoskeletal sarcomas.
  7. pmc Four cases of a cerebral air embolism complicating a percutaneous transthoracic needle biopsy
    Soo Jung Um
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
    Korean J Radiol 10:81-4. 2009
    A percutaneous transthoracic needle biopsy is a common procedure in the practice of pulmonology. An air embolism is a rare but potentially fatal complication of a percutaneous transthoracic needle biopsy...
  8. ncbi Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the disease
    Guido Colloredo
    Liver Unit, Seriate Hospital, Bergamo, Italy
    J Hepatol 39:239-44. 2003
    ..In chronic viral hepatitis, liver biopsy is performed for assessing disease activity and fibrosis. In this study, we evaluated the impact of the size of liver biopsy on the grading and staging...
  9. doi Personalized prediction of tumor response and cancer progression on prostate needle biopsy
    Michael J Donovan
    Aureon Laboratories, Inc, New York, New York 10701, USA
    J Urol 182:125-32. 2009
    ..We developed a patient specific, biology driven tool to predict outcome at diagnosis. We also investigated whether biopsy androgen receptor levels predict a durable response to therapy after secondary treatment...
  10. ncbi Bronchoscopy and needle biopsy techniques for diagnosis and staging of lung cancer
    Peter Mazzone
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Chest Med 23:137-58, ix. 2002
    ..Flexible bronchoscopy (FB) and transthoracic needle biopsy (TNB) are the most widely used techniques for this purpose...
  11. ncbi Management of the clinically inapparent adrenal mass ("incidentaloma")
    Melvin M Grumbach
    University of California, San Francisco, San Francisco, California, USA
    Ann Intern Med 138:424-9. 2003
    ..The panel also advocated a multidisciplinary approach to managing adrenal incidentalomas. The statement is an independent report of the panel and is not a policy statement of the National Institutes of Health or the federal government...
  12. ncbi Prospective evaluation of a 21-sample needle biopsy procedure designed to improve the prostate cancer detection rate
    Alexandre De La Taille
    Department of Urology, CHU Henri Mondor, Creteil, France
    Urology 61:1181-6. 2003
    To evaluate prospectively the diagnostic yield of a 21-sample ultrasound-guided needle biopsy procedure for prostate cancer in patients with elevated serum prostate-specific antigen and/or abnormal digital rectal examination findings.
  13. ncbi Prevalence of malignancy within cytologically indeterminate thyroid nodules
    Barbara Miller
    Department of Surgery, University of Texas Southwestern Medical Center, Department of Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390 9156, USA
    Am J Surg 188:459-62. 2004
    ..We examined the prevalence of malignancy within cytologically indeterminate follicular thyroid lesions in an attempt to predict malignancy based on cytologic features...
  14. ncbi Missed breast cancers at US-guided core needle biopsy: how to reduce them
    Ji Hyun Youk
    Department of Diagnostic Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seodaemun Ku, Shinchon Dong 134, Seoul 120 752, South Korea
    Radiographics 27:79-94. 2007
    Ultrasonographically (US) guided core needle biopsy is currently recognized as a reliable alternative to surgical biopsy for the histopathologic diagnosis of breast lesions...
  15. doi Utilization rates, complications and costs of percutaneous liver biopsy: a population-based study including 4275 biopsies
    Robert P Myers
    Department of Medicine, Division of Gastroenterology, Liver Unit, University of Calgary, Calgary, AB, Canada
    Liver Int 28:705-12. 2008
    ..Because biopsy practices may be changing, we studied patterns of use in a large Canadian Health Region. We aimed to describe trends in biopsy utilization and the incidence and costs of complications from a population-based perspective...
  16. doi EBUS-TBNA for the diagnosis of central parenchymal lung lesions not visible at routine bronchoscopy
    Kurt G Tournoy
    Department of Respiratory Medicine and Lung Oncologic Network, Ghent University Hospital, Ghent, Belgium
    Lung Cancer 63:45-9. 2009
    ..Obtaining a tissue diagnosis of malignancy is challenging in patients with suspected lung cancer presenting with centrally located intrapulmonary masses...
  17. ncbi A single injection of lidocaine as local anesthesia for ultrasound guided needle biopsy of the prostate
    Gianluigi Taverna
    Department of Urology, Istituto Clinico Humanitas, Rozzano Milan, Italy
    J Urol 167:222-3. 2002
    ..We evaluated the effectiveness of a single injection of lidocaine on patient tolerance of multiple needle biopsies of the prostate...
  18. ncbi Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions
    A Bartolazzi
    Department of Oncology Pathology, Cellular and Molecular Tumor Pathology, Cancer Center Karolinska, CCK R8 04 Karolinska Hospital, 17176, Stockholm, Sweden
    Lancet 357:1644-50. 2001
    ..We undertook an international multicentre study to assess the usefulness of immunohistocytochemical staining for two potential markers of malignant thyrocytes...
  19. ncbi Prospective evaluation of prostate cancer detected on biopsies 1, 2, 3 and 4: when should we stop?
    B Djavan
    Department of Urology, University of Vienna, Vienna, Austria
    J Urol 166:1679-83. 2001
    ..ml. These features were compared to those detected on prostate biopsy 1...
  20. ncbi Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes
    Kazuhiro Yasufuku
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Japan
    Chest 126:122-8. 2004
    ....
  21. pmc Diagnostic accuracy of large-core needle biopsy for nonpalpable breast disease: a meta-analysis
    H M Verkooijen
    Department of Surgery, University Hospital Utrecht, The Netherlands
    Br J Cancer 82:1017-21. 2000
    ..Five cohort studies were included in a meta-analysis. Sensitivity rate, histological agreement between needle biopsy and subsequent surgery or long-term mammographic follow-up and clinical consequences for different disease ..
  22. ncbi US-guided core-needle biopsy of the breast: how many specimens are necessary?
    Joel E Fishman
    Department of Radiology, University of Miami School of Medicine, Jackson Memorial Hospital Rm WW279, 1611 NW 12th Ave, Miami, FL 33136, USA
    Radiology 226:779-82. 2003
    ..To analyze the diagnostic yield for each specimen obtained at 14-gauge ultrasonography (US)-guided breast biopsy and compare these findings with mass, procedural, and specimen characteristics that could affect yield...
  23. ncbi Prognostic markers in breast cancer: the reliability of HER2/neu status in core needle biopsy of 325 patients with primary breast cancer
    Susanne Taucher
    Department of Surgery, Vienna University Medical School, Vienna, Austria
    Wien Klin Wochenschr 116:26-31. 2004
    ..Since core needle biopsy is increasingly used for the diagnosis of breast cancer, the purpose of this study was to assess the ..
  24. ncbi Risk of invasion and axillary lymph node metastasis in ductal carcinoma in situ diagnosed by core-needle biopsy
    P Meijnen
    Department of Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Br J Surg 94:952-6. 2007
    ..and axillary lymph node metastasis in patients with ductal carcinoma in situ (DCIS) diagnosed by preoperative core-needle biopsy. The data were used to select criteria for patients in whom sentinel node (SN) biopsy might be indicated.
  25. ncbi Preoperative diagnosis of clear cell "sugar" tumor of the lung by computed tomography-guided fine-needle biopsy and core-needle biopsy
    Marcia Edelweiss
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Ann Diagn Pathol 11:421-6. 2007
    ..and ultrastructurally to be CCST, and one case of CCST diagnosed preoperatively by transbronchial core-needle biopsy. We here depict an additional case of CCST of the lung that was preoperatively diagnosed by computed ..
  26. doi The value of 18F-choline PET/CT in patients with elevated PSA-level and negative prostate needle biopsy for localisation of prostate cancer
    I Igerc
    Department of Nuclear Medicine and Endocrinology, PET CT Center, Klagenfurt, State Hospital Klagenfurt, St Veiterstrasse 47, A 9020 Klagenfurt, Austria
    Eur J Nucl Med Mol Imaging 35:976-83. 2008
    ....
  27. doi PTOV1 expression predicts prostate cancer in men with isolated high-grade prostatic intraepithelial neoplasia in needle biopsy
    Juan Morote
    Department of Urology, Vall d Hebron Hospital, Vall d Hebron Hospital Research Institute, and Autónoma University of Barcelona, Barcelona, Spain
    Clin Cancer Res 14:2617-22. 2008
    To analyze the expression of PTOV1 in high-grade prostatic intraepithelial neoplasia (HG-PIN) and to explore its usefulness to predict prostate cancer in patients with isolated HG-PIN in needle biopsy (prostate needle biopsy).
  28. doi Evaluation of routine application of P504S, 34betaE12 and p63 immunostaining on 250 prostate needle biopsy specimens
    Kitty Pavlakis
    Pathology Department, Attikon University Hospital, University of Athens Medical School, 1 Rimini St, 12462, Athens, Greece
    Int Urol Nephrol 42:325-30. 2010
    We aimed to determine whether a standard P504S, 34betaE12 and p63 immunostaining of prostate core needle biopsy specimens can optimize diagnostic accuracy of conventional staining methods.
  29. doi Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4 + 3 as high or intermediate grade
    Deirdre M Fanning
    UCD School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
    BJU Int 105:631-5. 2010
    To assess the discrepancy between needle biopsy (NB) and radical prostatectomy (RP) Gleason score (GS) in Irish men, specifically the influence of the stratification of GS 4 + 3 on overall levels of agreement, levels of discrepancy and ..
  30. ncbi Aspiration needle biopsy in preoperative selection of thyroid nodules defined at fine-needle aspiration as microfollicular lesions
    A Carpi
    Department of Reproduction and Aging, University of Pisa, Italy
    Am J Clin Oncol 22:65-9. 1999
    ..The authors retrospectively assess the use of aspiration needle biopsy (either 16- or 18-gauge needles) in the preoperative selection of the nodules diagnosed as microfollicular at ..
  31. doi US-guided core needle biopsy of axillary lymph nodes in patients with breast cancer: why and how to do it
    Hiroyuki Abe
    Section of Breast Imaging, Department of Radiology, University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637, USA
    Radiographics 27:S91-9. 2007
    ..Although not widely performed for axillary lymph node staging, ultrasonography (US)-guided core needle biopsy is a well-established procedure for the breast and other organs, with a higher success rate in terms of tissue ..
  32. doi Extent and histologic pattern of atypical ductal hyperplasia present on core needle biopsy specimens of the breast can predict ductal carcinoma in situ in subsequent excision
    Michael J Wagoner
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, USA
    Am J Clin Pathol 131:112-21. 2009
    Atypical ductal hyperplasia (ADH) diagnosed by core needle biopsy (CNB) is regarded as an indication for surgical excision...
  33. pmc Breast cancer hormone receptor assay results of core needle biopsy and modified radical mastectomy specimens from the same patients
    Gemma B Uy
    Department of Surgery, Philippine General Hospital, University of the Philippines, Manila, Philippine
    Clin Breast Cancer 10:154-9. 2010
    ..Hormone receptor (HR) expression is the most important biomarker and is the cornerstone in the management of breast cancer. Therefore, the accuracy of its testing is critical in treatment decisions...
  34. pmc Office-based core needle biopsy of bone and soft tissue malignancies: an accurate alternative to open biopsy with infrequent complications
    Sheila C Adams
    Department of Orthopaedics and Rehabilitation, University of Miami Miller School of Medicine, University of Miami Hospital, 1400 NW 12th Avenue, Room 4036, Miami, FL 33136, USA
    Clin Orthop Relat Res 468:2774-80. 2010
    ..As an alternative to open biopsy, percutaneous core needle biopsy techniques have been developed...
  35. ncbi The diagnosis of GI stromal tumors with EUS-guided fine needle aspiration with immunohistochemical analysis
    Nobuhiro Ando
    Second Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Gastrointest Endosc 55:37-43. 2002
    ..EUS-guided fine needle aspiration (EUS-FNA) is useful for diagnosis of GISTs. The aim of this study was to evaluate the phenotyping of GISTs and diagnosis of malignant GISTs by using EUS-FNA with immunohistochemical analysis...
  36. ncbi Protocol core needle biopsy and histologic Chronic Allograft Damage Index (CADI) as surrogate end point for long-term graft survival in multicenter studies
    Serdar Yilmaz
    Data Analysis Center, Division of Transplantation, Department of Surgery, University of Calgary, Alberta, Canada
    J Am Soc Nephrol 14:773-9. 2003
    ..This observation makes it possible to use CADI as a surrogate end point in prevention trials and to identify the patients at risk for intervention trials...
  37. ncbi Comparison of percentage of total prostate needle biopsy tissue with cancer to percentage of cores with cancer for predicting PSA recurrence after radical prostatectomy: results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095 1738, USA
    Urology 61:742-7. 2003
    Tumor volume in the prostate needle biopsy is an important prognosticator for patients with prostate cancer. However, the best method to measure tumor volume in the prostate needle biopsy is unknown...
  38. ncbi Variability in hepatic iron concentration in percutaneous needle biopsy specimens from patients with transfusional hemosiderosis
    Ellen Butensky
    Department of Gastroenterology and Nutrition, Children s Hospital and Research Center at Oakland, CA 94609, USA
    Am J Clin Pathol 123:146-52. 2005
    ..0%. We found high agreement in LICs between liver biopsy specimens processed by the paraffin-embedding technique but overestimation of LICs in comparison with desiccated fresh tissue samples...
  39. ncbi Fibroepithelial lesions with cellular stroma on breast core needle biopsy: are there predictors of outcome on surgical excision?
    Timothy W Jacobs
    Department of Pathology, Virginia Mason Medical Center, Seattle, WA 98101, USA
    Am J Clin Pathol 124:342-54. 2005
    Fibroepithelial lesions with cellular stroma (FELCS) in breast core needle biopsy (CNB) specimens may result in either fibroadenoma or phyllodes tumor at excision...
  40. ncbi Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis
    Jian feng Lin
    Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Int J Cancer 121:2596-605. 2007
    ..cancer (PCa) detection, the definitive diagnosis of PCa is based on the information contained in prostate needle biopsy (PNBX) specimens...
  41. doi Prostate cancers diagnosed at repeat biopsy are smaller and less likely to be high grade
    Nelly Tan
    Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Urol 180:1325-9; discussion 1329. 2008
    ..We investigated whether prostate cancer diagnosed on initial prostate biopsy had worse pathological outcomes compared to that diagnosed on repeat prostate biopsy...
  42. ncbi Analysis of ret/PTC gene rearrangements refines the fine needle aspiration diagnosis of thyroid cancer
    C C Cheung
    Department of Pathology and Laboratory Medicine, The Freeman Center for Endocrine Oncology, Mount Sinai Hospital, University of Toronto, Ontario, Canada M5G 2M9
    J Clin Endocrinol Metab 86:2187-90. 2001
    ..The results indicate that RT-PCR for ret/PTC is a specific marker that can be applied to fine needle aspiration biopsies and improves the diagnosis of malignancy when used as an adjunct to traditional cytology...
  43. ncbi Predicting cancer following a diagnosis of high-grade prostatic intraepithelial neoplasia on needle biopsy: data on men with more than one follow-up biopsy
    J D Kronz
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 25:1079-85. 2001
    ..Although clinical findings at the time of diagnosis of high-grade PIN are not useful to predict who might have cancer, histologic findings may help identify who needs additional biopsies...
  44. ncbi Ductal lavage for detection of cellular atypia in women at high risk for breast cancer
    W C Dooley
    Institute for Breast Health, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    J Natl Cancer Inst 93:1624-32. 2001
    ..In this study, ductal lavage, a new procedure for collecting ductal cells with a microcatheter, was compared with nipple aspiration with regard to safety, tolerability, and the ability to detect abnormal breast epithelial cells...
  45. ncbi [Fatal septic shock caused by transrectal needle biopsy of the prostate; a case report]
    Taro Hasegawa
    Department of Urology, Jikei University, School of Medicine
    Kansenshogaku Zasshi 76:893-7. 2002
    ..The prostate had numerous microabscesses. Currently, transrectal prostate biopsy is considered a generally reliable procedure to detect adenocarcinoma of the prostate. Our case seems to the sixth case report of fatal complications...
  46. ncbi The relationship of prostate gland volume to extended needle biopsy on prostate cancer detection
    Jean O Ung
    Department of Urologic Surgery and Biometrics Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Urol 169:130-5. 2003
    We investigated the relationship between prostate volume and cancer detection by needle biopsy, and determined the effect of an increased number of cores on the sampling error of needle biopsy on large prostate glands.
  47. ncbi Endoscopic ultrasound-guided fine-needle aspiration findings of gastrointestinal leiomyomas and gastrointestinal stromal tumors
    Edward B Stelow
    Dept of Pathology and Laboratory Medicine, Hennepin County Medical Center, Mail Code 815, 701 Park Ave, Minneapolis, MN 55415, USA
    Am J Clin Pathol 119:703-8. 2003
    ....
  48. ncbi Transthoracic needle biopsy: factors effecting risk of pneumothorax
    Ugur Topal
    Department of Radiology, Uludag University Medical School, Gorukle Campus, 16059 Bursa, Turkey
    Eur J Radiol 48:263-7. 2003
    ..to evaluate the factors that could effect the risk of pneumothorax in patients undergoing transthoracic biopsy...
  49. doi Infectious complications from full extension endobronchial ultrasound transbronchial needle aspiration
    A R Haas
    Interventional Pulmonary Program, Division of Pulmonary Medicine and Critical Care, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA
    Eur Respir J 33:935-8. 2009
    ....
  50. ncbi Prediction of extraprostatic extension in the neurovascular bundle based on prostate needle biopsy pathology, serum prostate specific antigen and digital rectal examination
    Toyonori Tsuzuki
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    J Urol 173:450-3. 2005
    ..We investigated whether clinical information and prostate biopsy data could predict EPE of clinical localized prostate cancer...
  51. ncbi Fine-needle percutaneous biopsy of renal masses with helical CT guidance
    E Lechevallier
    Departments of Urology, Hopital Salvator, 249 Blvd Ste Marguerite, 13274 Marseille, France
    Radiology 216:506-10. 2000
    ..To evaluate the feasibility, accuracy, and clinical role of fine-needle percutaneous biopsy of renal masses, with helical computed tomographic (CT) guidance...
  52. ncbi Ductal carcinoma in situ diagnosed with stereotactic core needle biopsy: can invasion be predicted?
    C H Lee
    Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Radiology 217:466-70. 2000
    ..whether mammographic or histologic features can be used to predict which cases diagnosed as ductal carcinoma in situ (DCIS) without invasion by means of stereotactic core needle biopsy (SCNB) will have invasive disease at surgery.
  53. ncbi The incidence and the risk of pneumothorax and chest tube placement after percutaneous CT-guided lung biopsy: the angle of the needle trajectory is a novel predictor
    Hisashi Saji
    Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Chest 121:1521-6. 2002
    ..The aims of this study were to estimate the risk of pneumothorax in patients undergoing CT-guided lung biopsy, and to determine which factors affect its occurrence...
  54. ncbi Diagnosis of "follicular neoplasm": a gray zone in thyroid fine-needle aspiration cytology
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 26:41-4. 2002
    ..However, clinical features, including gender, nodule size, and age, can be a part of the decision analysis in selecting patients for surgery...
  55. ncbi Evaluation of liver fibrosis: a concise review
    Nezam H Afdhal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02125, USA
    Am J Gastroenterol 99:1160-74. 2004
    ..The limitations of utilization of these markers for both cross-sectional diagnosis of fibrosis and monitoring disease progression or regression are discussed...
  56. doi Acute bacterial prostatitis after transrectal prostate needle biopsy: clinical analysis
    Kazuyoshi Shigehara
    Department of Urology, Ishikawa Prefectural Central Hospital, 2 1 Kuratsukihigashi, Kanazawa, Ishikawa, Japan
    J Infect Chemother 14:40-3. 2008
    ..Treatment with cephalosporin or carbapenem is recommended for patients with acute prostatitis after prostate biopsy...
  57. ncbi Ultrasound-guided fine needle biopsy of the spleen: high clinical efficacy and low risk in a multicenter Italian study
    G Civardi
    Divisione di Medicina Interna Ematologia, Ospedale Civile, Piacenza, Italy
    Am J Hematol 67:93-9. 2001
    The aim of this study was to evaluate the clinical efficacy and safety of the ultrasound-guided fine needle biopsy (UG-FNB) of the spleen in a large population of patients...
  58. ncbi Freehand iMRI-guided large-gauge core needle biopsy: a new minimally invasive technique for diagnosis of enhancing breast lesions
    B L Daniel
    Department of Radiology, Stanford University, Stanford, California 94305, USA
    J Magn Reson Imaging 13:896-902. 2001
    ..In this study, a freehand method was developed for large-gauge core needle biopsy (LCNB) guided by intraprocedural MRI (iMRI)...
  59. ncbi Core needle biopsy as a diagnostic tool to differentiate phyllodes tumor from fibroadenoma
    Ian K Komenaka
    Comprehensive Breast Center, Columbia University, and Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Arch Surg 138:987-90. 2003
    Core needle biopsy is a useful diagnostic tool in differentiating phyllodes tumor from fibroadenoma.
  60. ncbi Liposarcoma subtypes: identification with computed tomography and ultrasound-guided percutaneous needle biopsy
    Paul Nikolaidis
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur Radiol 15:383-9. 2005
    The purpose of the study was to evaluate the feasibility of image-guided percutaneous needle biopsy to enable specific subtype classification of liposarcoma in patients with previously diagnosed disease and compare the yield of fine and ..
  61. ncbi CT-guided percutaneous core needle biopsy in deep seated musculoskeletal lesions: a prospective study of 128 cases
    A Puri
    Orthopaedic Oncology Service, Tata Memorial Hospital, E Borges Marg, Parel, Mumbai, India
    Skeletal Radiol 35:138-43. 2006
    ..A prospective study of CT-guided core needle biopsies for deep-seated musculoskeletal lesions was conducted at a referral cancer institute over a 4-year period with the aim of assessing the safety and efficacy of the procedure...
  62. ncbi Safety and detailed patterns of morbidity of transrectal ultrasound guided needle biopsy of prostate in a urologist-led unit
    George Lee
    Department of Urology, Wexham Park Hospital, 8 Marloes Road, W8 5LJ, Slough, Berks, UK
    Int Urol Nephrol 38:281-5. 2006
    ..evaluate the safety, morbidity and characteristics of complications for transrectal ultrasound guided needle biopsy of prostate carried out solely by urologists in a single unit...
  63. ncbi Chronic inflammation is negatively associated with prostate cancer and high-grade prostatic intraepithelial neoplasia on needle biopsy
    P I Karakiewicz
    Department of Urology, Cancer Prognostics and Health Outcomes Unit, University of Montreal, 1058 rue St Denis, Montreal, Quebec, Canada
    Int J Clin Pract 61:425-30. 2007
    ..and prostate cancer (PCa), as well as high-grade prostatic intraepithelial neoplasia (HGPIN), in prostatic needle biopsy specimens...
  64. ncbi Ultrasound-guided core-needle biopsy in the diagnosis of head and neck masses: indications, technique, and results
    Jens Pfeiffer
    Department of Otorhinolaryngology Head and Neck Surgery, Freiburg Medical School, Freiburg, Germany
    Head Neck 29:1033-40. 2007
    ..Unclear cervicofacial masses are common presentations that often require tissue sampling to guide therapy. While open biopsy is invasive, fine-needle aspiration cytology includes a high rate of nondiagnostic samples...
  65. ncbi Transjugular liver biopsy--indications, adequacy, quality of specimens, and complications--a systematic review
    George Kalambokis
    The Sheila Sherlock Hepatobiliary Pancreatic and Liver Transplantation Unit, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
    J Hepatol 47:284-94. 2007
    ..In adults, mortality was 0.09% (haemorrhage 0.06%; ventricular arrhythmia 0.03%). TJLB is safe, providing specimens qualitatively comparable to PLB, and may improve further using > or = 18-G Tru-Cut needle and >3 passes...
  66. ncbi Ultrasound-guided core needle biopsy of breast masses: How many cores are necessary to diagnose cancer?
    Clécio Ênio Murta de Lucena
    Santa Casa de Belo Horizonte, Universidade Federal de Minas Gerais, Avenida Bernardo Monteiro, no 1470, apto 1202, Bairro Funcionários, Belo Horizonte, Minas Gerais, Brazil
    J Clin Ultrasound 35:363-6. 2007
    To investigate the number of cores required to diagnose breast cancer using ultrasound (US)-guided core needle biopsy.
  67. ncbi Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage
    Abdurrahman Sagir
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinik Düsseldorf, Dusseldorf, Germany
    Hepatology 47:592-5. 2008
    ..5 kPa. Six patients with initially high liver stiffness were followed up to abatement of the acute hepatitic phase; in all of them, liver stiffness values decreased to values below the cutoff value for liver cirrhosis...
  68. ncbi Ultrasound-guided core-needle biopsy: is it effective in the diagnosis of suspected lymphomas presenting in the head and neck?
    Antonino Carbone
    J Surg Oncol 98:4-5. 2008
  69. doi Prostate cancer detection rate in patients with repeated extended 21-sample needle biopsy
    Jean Louis Campos-Fernandes
    Department of Urology, CHU Mondor, Creteil, France
    Eur Urol 55:600-6. 2009
    Prevalence of prostate cancer (PCa) after a negative first extended prostate needle biopsy protocol is unknown.
  70. doi Unsuccessful preoperative biopsies, fine needle aspiration cytology or core needle biopsy, lead to increased costs in the diagnostic workup in breast cancer
    Katja Hukkinen
    Department of Radiology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Oncol 47:1037-45. 2008
    ..Our aim was to compare feasibility of fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) in diagnosis of breast lesions...
  71. doi Percutaneous needle biopsy for breast diagnosis: how do surgeons decide?
    Claire M B Holloway
    Department of Surgery, Sunnybrook Health Sciences Centre and the University of Toronto, ON, Canada
    Ann Surg Oncol 16:1629-36. 2009
    Despite the advent of guidelines recommending core needle biopsy (CNB) for diagnosis of breast abnormalities, it is underused in some jurisdictions...
  72. pmc The diagnostic value of needle biopsy for musculoskeletal lesions
    Ki Sun Sung
    Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon Dong 50, Gangnam Gu, Seoul, 135 710, Korea
    Int Orthop 33:1701-6. 2009
    The purpose of this study was to assess the diagnostic value of imaging-guided core needle biopsy for the diagnosis of musculoskeletal lesions...
  73. ncbi Preoperative histologic assessment of head and neck lesions using cutting needle biopsy
    Yoshihiro Yamashita
    Kyushu Dental College, Kitakyushu, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:528-33. 2002
    This study assessed the clinical utility of cutting needle biopsy in which a newly developed Monopty biopsy instrument (MBI) (Monopty, Bard Urologic Division; Covington, Ga) was used in the preoperative assessment of head and neck lesions.
  74. ncbi Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma
    Jerald Z Gong
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Diagn Cytopathol 31:23-30. 2004
    ..All the cases had cytology and core-needle biopsy and 53 cases had concurrent flow cytometric analysis...
  75. ncbi Finding a balanced strategy in prostate cancer diagnosis for case detection by prostate needle biopsy at first presentation: "all for more cores and more cores for all" or individualised sampling regimens? Which way forward?
    Anup Patel
    Eur Urol 52:313-5. 2007
  76. ncbi Systemic air embolism after percutaneous transthorasic needle biopsy of the lung
    Mahyar Ghafoori
    Department of Radiology, Hazrat Rasoul Akram University Hospital, Iran University of Medical Sciences, Tehran, Iran
    Emerg Radiol 15:353-6. 2008
    ..This extremely rare complication is an inevitable event and may happen in spite of appropriate experience and meticulous care...
  77. doi Percutaneous imaging-guided solid organ core needle biopsy: coaxial versus noncoaxial method
    Malcolm K Hatfield
    Milwaukee Radiologists, Ltd, affiliated with Aurora St Luke s Medical Center, Milwaukee, WI, USA
    AJR Am J Roentgenol 190:413-7. 2008
    ..We also compared bleeding complication rates with and without absorbable gelatin sponge occlusion of the biopsy track...
  78. doi The presence of micropapillary features and retraction artifact in core needle biopsy material predicts lymph node metastasis in breast carcinoma
    Geza Acs
    Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Am J Surg Pathol 33:202-10. 2009
    ..We examined whether the presence and extent of micropapillary features and retraction artifact in core needle biopsy of breast cancers can predict nodal metastasis in a prospective series of 47 IMPC and 424 IDC...
  79. doi Solitary fibrous tumour of the prostate identified on needle biopsy
    Andrea B Galosi
    Urology Institute, Polytechnic University of the Marche Region, Azienda Ospedaliero Universitaria, Ancona, Italy
    Eur Urol 56:564-7. 2009
    ..and radical prostatectomy features of a case of solitary fibrous tumour (SFT) of the prostate identified on needle biopsy are presented. The main differential diagnoses are discussed...
  80. doi Axillary staging by percutaneous biopsy: sensitivity of fine-needle aspiration versus core needle biopsy
    Roshni Rao
    Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Ann Surg Oncol 16:1170-5. 2009
    We sought to determine whether percutaneous core needle biopsy (CNB) of suspicious axillary lymph nodes in patients with breast cancer offers improved diagnostic accuracy compared with fine-needle aspiration (FNA).
  81. ncbi High-grade prostatic intraepithelial neoplasia on needle biopsy: risk of cancer on repeat biopsy related to number of involved cores and morphologic pattern
    Tarek Bishara
    Pee Dee Pathology Associates, Florence, SC, USA
    Am J Surg Pathol 28:629-33. 2004
    The importance of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) on needle biopsy is its association with synchronous invasive carcinoma. The relevance of this relationship has been called into question in recent years...
  82. ncbi Risk of pleural recurrence after needle biopsy in patients with resected early stage lung cancer
    Haruhisa Matsuguma
    Division of Thoracic Surgery, Tochigi Cancer Center, Utsunomiya, Tochigi, Japan
    Ann Thorac Surg 80:2026-31. 2005
    Concerning the complications resulting from percutaneous needle biopsy (PNB), although cases of tumor seeding into the needle track have occasionally been reported, there were only two cases of pleural recurrences to date...
  83. doi Diagnosis of autoimmune pancreatitis by core needle biopsy: application of six microscopic criteria
    Sönke Detlefsen
    Department of Pathology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 3, Haus 14, 24105, Kiel, Germany
    Virchows Arch 454:531-9. 2009
    ..The aim of this study was to evaluate the efficacy of pancreatic core needle biopsy for the diagnosis of AIP...
  84. ncbi Repeat biopsy strategy in patients with atypical small acinar proliferation or high grade prostatic intraepithelial neoplasia on initial prostate needle biopsy
    P G Borboroglu
    Department of Urology, Naval Medical Center-San Diego, 34800 Bob Wilson Drive, Suite 5, San Diego, CA 92134-1005, USA
    J Urol 166:866-70. 2001
    ..The optimal repeat biopsy strategy in this setting should include bilateral biopsies of the standard sextant locations. We also strongly recommend that transition zone sampling should be considered...
  85. ncbi The feasibility of using fine needle aspiration from primary breast cancers for cDNA microarray analyses
    Laura Assersohn
    Royal Marsden Hospital, Surrey SM2 5PT, United Kingdom
    Clin Cancer Res 8:794-801. 2002
    ....
  86. ncbi Difference of cancer core distribution between first and repeat biopsy: In patients diagnosed by extensive transperineal ultrasound guided template prostate biopsy
    Tsuyoshi Furuno
    Department of Urology, Sapporo Kosei Hospital, Sapporo, Japan
    Prostate 58:76-81. 2004
    ..We performed extensive transperineal ultrasound guided template prostate biopsy and evaluated cancer core distribution...
  87. ncbi Three-dimensional ultrasound-validated large-core needle biopsy: is it a reliable method for the histological assessment of breast lesions?
    L Delle Chiaie
    Centre for Ultrasound and Prenatal Diagnosis, Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany
    Ultrasound Obstet Gynecol 23:393-7. 2004
    ..The aim of this study was to demonstrate the efficacy of 3D ultrasound-validated large-core needle biopsy (LCNB) of the breast.
  88. ncbi Prostate cancer detection with office based saturation biopsy in a repeat biopsy population
    John C Rabets
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Urol 172:94-7. 2004
    ..We now report the diagnostic yield of office saturation biopsy in patients at increased risk for prostate cancer and at least 1 negative prior biopsy...
  89. pmc Ultrasound guided fine needle biopsy of early hepatocellular carcinoma complicating liver cirrhosis: a multicentre study
    E Caturelli
    Unità Operativa di Gastroenterologia, Ospedale Belcolle, Strada Sammartinese, 01100 Viterbo, Italy
    Gut 53:1356-62. 2004
    ....
  90. ncbi Prostate needle biopsy: 12 vs. 18 cores -- is it necessary?
    Pietro Pepe
    Urology Unit, Cannizzaro Hospital, Catania, Italy
    Urol Int 74:19-22. 2005
    The aim of this study is to compare the histological results of a prostate needle biopsy scheme of 12 and 18 cores used in 372 consecutive patients submitted to an early stage diagnosis programme for prostate cancer (PCa).
  91. ncbi Biopsy of resectable colorectal liver metastases causes tumour dissemination and adversely affects survival after liver resection
    O M Jones
    Department of Hepatobiliary Surgery, North Hampshire Hospital, Aldermaston Road, Basingstoke RG24 9NA, UK
    Br J Surg 92:1165-8. 2005
    ..Liver resection is increasingly being performed for metastatic colorectal cancer. This study assessed the need for preoperative biopsy of suspected metastases and whether biopsy has any effect on long-term survival...
  92. pmc Preoperative assessment of hepatocellular carcinoma tumor grade using needle biopsy: implications for transplant eligibility
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Ann Surg 245:435-42. 2007
    ..To examine the diagnostic agreement of preoperative needle core biopsy (NCB) grading of hepatocellular carcinoma (HCC) compared with the final surgical pathologic tumor grade...
  93. ncbi Comparison of a 3-day with a 1-day regimen of an extended-release formulation of ciprofloxacin as antimicrobial prophylaxis for patients undergoing transrectal needle biopsy of the prostate
    Anthony J Schaeffer
    Department of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    BJU Int 100:51-7. 2007
    ..and the clinical safety of a 1-day with a 3-day regimen of an extended-release formulation of ciprofloxacin (ciprofloxacin XR) given as antimicrobial prophylaxis to men undergoing transrectal needle biopsy of the prostate (TRNBP).
  94. ncbi Ultrasonography and core needle biopsy in the differential diagnosis of fibroadenoma and tumor phyllodes
    M K Bode
    Departments of Diagnostic Radiology and Pathology, Oulu University Hospital, FIN 90029 OYS, Oulu, Finland
    Acta Radiol 48:708-13. 2007
    ..The diagnosis of phyllodes tumors of the breast is challenging due to many similarities with common fibroadenomas...
  95. doi Aberrant diffuse expression of p63 in adenocarcinoma of the prostate on needle biopsy and radical prostatectomy: report of 21 cases
    Adeboye O Osunkoya
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:461-7. 2008
    ..We studied 19 cases of prostate cancer with aberrant diffuse expression of p63 on needle biopsy and reviewed the subsequent radical prostatectomies in 6 cases...
  96. doi Plasmablastic lymphoma involving breast: a case diagnosed by fine-needle aspiration and core needle biopsy
    Jun Wang
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Diagn Cytopathol 36:257-61. 2008
    ..Molecular genetic studies showed clonal rearrangement of the immunoglobulin kappa light chain gene. This is the first case of PBL involving the breast reported in English cytological literature...
  97. doi Grading of invasive cribriform carcinoma on prostate needle biopsy: an interobserver study among experts in genitourinary pathology
    Mathieu Latour
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:1532-9. 2008
    ..Out of 3590 prostate cancers sent to one of the authors over 7 months, 30 needle biopsy cases were selected that possibly represented cribriform Gleason pattern 3 cancer...
  98. doi Overexpression of CD24, c-myc and phospholipase 2A in prostate cancer tissue samples obtained by needle biopsy
    Balint Nagy
    Genetic Laboratory, 1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
    Pathol Oncol Res 15:279-83. 2009
    ..Prostate tissue samples were collected by needle biopsy from 20 prostate cancer (PCA) and 11 benign prostate hyperplasic (BPH) patients...
  99. doi Anticoagulation and bleeding risk after core needle biopsy
    Patricia Somerville
    The Elizabeth Wende Breast Clinic, 170 Sawgrass Dr, Rochester, NY 14620, USA
    AJR Am J Roentgenol 191:1194-7. 2008
    The objective of our study was to compare the bleeding complication rates after core needle biopsy in patients receiving anticoagulation therapy and those who had not to assess the safety of performing core needle breast biopsy in ..
  100. doi Upright stereotactic vacuum-assisted needle biopsy of suspicious breast microcalcifications
    L S J Sim
    Department of Diagnostic Radiology, Singapore General Hospital, Singapore
    J Med Imaging Radiat Oncol 52:358-64. 2008
    Stereotactic core needle biopsy is a useful technique for evaluation of suspicious breast microcalcifications...
  101. doi Ultrasound-guided core needle biopsy of parotid gland swellings
    R Pratap
    Department of Otolaryngology, Norfolk and Norwich University Hospital, Norwich, UK
    J Laryngol Otol 123:449-52. 2009
    To determine whether ultrasound-guided core needle biopsy is a safe and reliable investigation in cases of parotid swelling in which fine needle aspiration cytology has failed to give a definitive diagnosis.

Research Grants68

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Robot-Assisted MRI-Guided Prostate Biopsy
    Dan Stoianovici; Fiscal Year: 2010
    ..b>Needle biopsy is a regularly performed procedure that is required for diagnosing prostate cancer (PC). An estimated 1...
  3. A Molecular targeting agent for systemic radiotherapy of metastatic Prostate Canc
    Kevin P Maresca; Fiscal Year: 2010
    ..current screening method of PSA levels in the blood is valuable for early detection, the confirmation by fine needle biopsy does not give a representative evaluation of the entire prostate or determine lymph node involvement...
  4. Development of high-throughput, commercially viable, Cell-CT instrument with init
    Thomas Neumann; Fiscal Year: 2010
    ..g., blood, sputum, cervical scrape, breast aspirate, urine, colon brushing, fine needle biopsy). Similar to flow cytometry, cells are injected into a capillary tube...
  5. Zinc-Based Early Detection of Prostate Cancer
    Christopher J Frederickson; Fiscal Year: 2010
    ..for prostatectomy (ii) men scheduled for cysto-prostatectomy (iii) men scheduled for saturation (64 core) needle biopsy and (iv) men scheduled for conventional biopsy...
  6. Metabolomic Markers for Early Detection of Prostate Cancer
    Arun Sreekumar; Fiscal Year: 2010
    ..Importantly, PSA has very low specificity for the cancer and hence needle biopsy is routinely implemented for unequivocal detection of the disease...
  7. Leucine Type Amino Acid Transport In Gliomas
    MARK MYRON GOODMAN; Fiscal Year: 2012
    ..respectively in low and high grade gliomas during the course of the patient's treatment: a) After tumor needle biopsy;b) After the initial cycle of radiation therapy;c) When MR imaging indicates tumor progression;2) Perform anti-..
  8. Sebastiano Gattoni-Celli; Fiscal Year: 2016
    ..pathology status will be measured by the change in Gleason score and the number of positive cores in prostate needle biopsy specimens between baseline and the end of the study...
  9. Exercise adaptations in mitochondrial myopathy: therapeutic implications
    Ronald G Haller; Fiscal Year: 2012
    ..Research Design: Patients will undergo physiological exercise testing, cardiac evaluation and muscle needle biopsy and then be randomized to regular exercise training or no training for 6 months with retesting at the end of ..
  10. Ron Alterovitz; Fiscal Year: 2014
    ..the parenchyma can be avoided by image-guided steering) and pneumothorax (since, in contrast to transthoracic needle biopsy, our device never punctures the pleura around the lung)...
  11. Histopathologic and Immunohistochemical Features of Tissue Adherent to the Electr
    CONSTANTINOS THASOS SOFOCLEOUS; Fiscal Year: 2011
    ..positive tumor cells) identified in tissue from the ablated tumor (adherent to the electrode and obtained with needle biopsy) is an independent predictor of LTP and treatment failure after RFA of CRHM. 2...
  12. Ultrafast Tomosynthesis for Transbronchial Biopsy Guidance
    Rebecca Fahrig; Fiscal Year: 2011
    ..Transbronchial needle biopsy (TBNbx) is preferred over other options because it is minimally invasive, and it has been shown to be more ..
  13. Surrogate and Sentinal Technologies to Monitor Stability of Cancer Phosphoprotein
    Lance Liotta; Fiscal Year: 2009
    ..measure at least 100 known phosphoprotein endpoints with high precision and sensitivity in a human core needle biopsy or fine needle aspirate...
  14. Elizabeth S Burnside; Fiscal Year: 2014
    ..Our clinical application is as compelling as our algorithmic work. Image-guided core needle biopsy of the breast is a common procedure that is imperfect, has high-stakes, and is particularly amenable to ..
  15. Micro-Spectroscopy for Cytological Screening, and Staging of Disease
    Max Diem; Fiscal Year: 2010
    ..is used to detect changes in the morphology of cells obtained from body fluids, or by exfoliation or thin needle biopsy, while in classical pathology stained tissue sections are examined visually...
  16. Axial Shear Strain Elastography In Benign and Malignant Breast Disease
    Jonathan Ophir; Fiscal Year: 2012
    ..Ultrasound guided core needle biopsy or surgical excision will serve as the pathological benchmark...
  17. Identification of a sensitive and specific panel of DNA methylated markers to imp
    GANGNING NONE LIANG; Fiscal Year: 2013
    ..histological changes and can be detected in small amounts of tissue, measurement of DNA methylation markers in needle biopsy material would be able to identify malignant SRMs...
  18. Microfluidic Devices for Molecular Characterization of Cancer Cells at the Single
    John Zhong; Fiscal Year: 2010
    ..cells;5) malignant cells captured by laser capture microdissection (LCM);and 6) suspicious malignant cells in needle biopsy. Isolation methods have been developed to capture rare cancer cells from blood and other tissues for cancer ..
  19. Molecuar Sub-typing of Prostate Cancer Based on Recurrent Gene Fusions
    Arul M Chinnaiyan; Fiscal Year: 2013
    ..molecular sub-types of prostate cancer with clinical outcome and/or aggressiveness of disease using prostate needle biopsy samples...
  20. Raman spectroscopy probes for assisting stereotactic breast biopsy needle placeme
    Stephen Fulghum; Fiscal Year: 2009
    Stereotactic, large-core, needle biopsy using a prone biopsy table and guided by imaging, is now accepted as an alternative to open surgical biopsy for non-palpable breast lesions discovered by mammography...
  21. Pyrophosphorolysis-activatable helicase dependent amplification assay for lung ca
    BERTRAND LEMIEUX; Fiscal Year: 2007
    ..are often difficult (due to thoracic location of tumor which increases the chance of lung collapse with a needle biopsy), the development of a non-invasive method to assay for the emergence of resistance would be a significant ..
  22. CT fluoroscopy guided robotically assisted lung biopsy
    Kevin Cleary; Fiscal Year: 2003
    ..an existing robotic system to assist the physician in accurate computed tomography (CT) fluoroscopy-guided needle biopsy of lung nodules...
  23. CT fluoroscopy guided robotically assisted lung biopsy
    Kevin Cleary; Fiscal Year: 2005
    ..an existing robotic system to assist the physician in accurate computed tomography (CT) fluoroscopy-guided needle biopsy of lung nodules...
  24. Synergistic CT-Bronchoscopy for Lung-Cancer Assessment
    William Higgins; Fiscal Year: 2007
    ..Transcutaneous needle biopsy also has low yield for small nodules and has other potential complications...
  25. PHILIPP STOLKA; Fiscal Year: 2014
    ..The first aim will develop and evaluate an easy-to-use guidance system for targeted needle biopsy by focusing on the development of the guidance platform itself, including device construction, internal ..
  26. Race, Lipoprotein Lipase and Obesity after Menopause
    Andrew Goldberg; Fiscal Year: 2007
    ..in AA compared to CAU postmenopausal women using tissue obtained during elective abdominal surgery and by needle biopsy, and 2) WL, by reducing SM (vastus lateralis - and SAT-LPL activity, is associated with a decrease in SM and ..
  27. Biodegradable Sealant for Biopsy Tracts in Soft Tissues
    LUCJAN HRONOWSKI; Fiscal Year: 2003
    Percutaneous fine needle biopsy is a common method of determining if a lung nodule is benign or malignant...
  28. BIOARTIFICIAL MUSCLES FOR GENE THERAPY
    Herman Vandenburgh; Fiscal Year: 2002
    ..Muscle stem cells (myoblasts) can be isolated by simple needle biopsy and genetically modified to express foreign proteins...
  29. Targeted prostate biopsy using mathematical optimization
    Christos Davatzikos; Fiscal Year: 2007
    ..Therefore, needle biopsy of the prostate has been widely used as a gold standard for the diagnosis and staging of prostate cancer, when ..
  30. Sealing Liver Biopsy Tracts with Hydrogels
    LUCJAN HRONOWSKI; Fiscal Year: 2006
    ..The most common type of liver biopsy is a percutaneous (through the skin) needle biopsy. Ultrasonography or Computed Tomography (CT) scans may be used to aid in the procedure to identify lesions in ..
  31. Thin Film Magnetic Sensors for Ultrathin Bronchoscope Navigation
    ERIK LANGE; Fiscal Year: 2006
    ..fail and must be repeated or replaced with more invasive approaches such as fluoroscopic guided percutaneous needle biopsy or surgical biopsy...
  32. INFLUENCE OF ACUTE ILLNESS AND INJURY ON ENERGY EXCHANGE
    John Kinney; Fiscal Year: 1980
    ..Current studies are seeking the mechanism for this difference. The percutaneous needle biopsy of thigh muscle in acutely injured patients reveals prompt elevations of certain free amino acids yet a 50% ..
  33. Biomarker Models of Prostate Cancer Outcome After Radiotherapy
    Alan Pollack; Fiscal Year: 2010
    ..Based on our prior experience, typical prostate needle biopsy specimens in patients with high-risk prostate cancer allow for about 7 markers to be quantified per case...
  34. CCD X-RAY FLUOROSCOPY USING BINARY OPTICAL TECHNIQUE
    Hong Liu; Fiscal Year: 2000
    ..We will conduct contrast-detail analysis, needle biopsy, and observer studies, comparing the proposed system to image intensifier fluoroscopic systems and ..
  35. MRI Method for In Vivo Iron Quantification
    Jens Jensen; Fiscal Year: 2007
    ..As validation, the MRI predictions will be correlated to results of needle biopsy of the liver, the current clinical gold standard...
  36. OCT Image-guided Biopsy Needle
    Xingde Li; Fiscal Year: 2006
    ..The imaging needle is not intended to replace the conventional needle biopsy and histology, but rather to optimize tissue sampling by directing the biopsy to areas of highest yield...
  37. PATHWAYS OF SKELETAL MUSCLE GLUCOSE METABOLISM IN MAN
    Lawrence Mandarino; Fiscal Year: 1991
    ..Muscle samples will be obtained by needle biopsy to assess insulin activation of pyruvate dehydrogenase (PDH) and glycogen synthase (GS), which catalyze key ..
  38. CHARACTERIZATION OF HUMAN LIVER CYTOCHROMES P450
    Judy Raucy; Fiscal Year: 1992
    ..Using needle biopsy samples from individuals exposed to various quantities of ethanol for different lengths of time and subjecting ..
  39. BIOMORPHOMETRY OF HUMAN PROSTATIC CANCER
    PRIYA WERAHERA; Fiscal Year: 2005
    ..The first Aim is directed at the development of advanced strategies for prostate needle biopsy. Studies on modification of existing biopsy techniques based on the presence of an elevated PSA, abnormal DRE, ..
  40. Ethanol effects on liver in self-administering primates
    Carol Cunningham; Fiscal Year: 2004
    ..Urinary concentrations of isoprostanes will be measured to screen for ethanol-related oxidative stress. Liver needle biopsy samples, taken every 3 months, will be examined by light and electron microscopy for indices of liver damage, ..
  41. Combined Ultrasound and Electrical Impedance Tomography
    JONATHAN NEWELL; Fiscal Year: 2006
    ..cysts and solid lesions, to identify palpable abnormalities, and to guide interventional procedures such as needle biopsy. Weaknesses of ultrasound include lack of adequate spatial resolution and its inability to image well in dense ..
  42. SUBSPECKLE VISIBILITY SMALL HYPOECHOGENIC BREAST TUMORS
    BERNARD STEINBERG; Fiscal Year: 1999
    ..Current clinical practice (particularly needle biopsy) would be largely sufficient if the first two problems were solved...
  43. Smart Optical Probe for Guidance of Fine Needle Biopsy
    Nicusor Iftimia; Fiscal Year: 2006
    ..It is evident that earlier diagnosis results in an improved outcome and reduced mortality from disease. [unreadable] [unreadable]..
  44. Effects of Lycopene on High-Risk Prostatic Tissue
    Peter Gann; Fiscal Year: 2005
    ..effects, after 6 months, of lycopene supplements (30 mg/day) on molecular and cell morphology markers in core needle biopsy samples from men with documented HGPIN...
  45. LX MULTI-NUCLEAR SPECTROSCOPY PACKAGE
    Russell Richardson; Fiscal Year: 2000
    ..Its non-invasive nature raises it above the traditional needle biopsy technique to repeatedly assess metabolic conditions within skeletal muscle in both healthy and diseased states...
  46. Protein NanoArray for Cytokine Profiling in Mouse Models
    Eric Henderson; Fiscal Year: 2004
    ..We predict that our system will provide robust protein profiling data from mouse tail-bleeds, needle biopsy aspirates, and finger pricks of human blood samples...
  47. Optical Coherence Tomography Image-Guided Surgical Resection of Solid Tumors
    Stephen Boppart; Fiscal Year: 2009
    ..surgical interventions of mammary tumors in an open surgical field and with an integrated tissue-sampling OCT needle biopsy probe...
  48. Difuse Optical Spectroscopy Breast Needle Biopsy
    NIMMI RAMANUJAM; Fiscal Year: 2004
    Percutaneous, image-guided core needle biopsy is being increasingly used to diagnose breast cancer...
  49. UVEAL MELANOMA CELL BIOLOGY
    DEVRON CHAR; Fiscal Year: 1992
    ..We will determine if DNA content abnormalities, especially on fine needle biopsy, can be used to increase prognostic accuracy...
  50. COMPARATIVE STUDIES OF INTRACELLULAR GLUCOSE METABOLISM
    Robert Henry; Fiscal Year: 1992
    ..are occurring in the primary peripheral target organ, samples or quadriceps femoris muscle will be obtained by needle biopsy during these studies for determination of glycolytic pathway metabolites and the rate limiting enzyme for ..
  51. Diagnosis of Breast Cancer with Optical Spectroscopy
    NIMMI RAMANUJAM; Fiscal Year: 2007
    Percutaneous, image-guided core needle biopsy is being increasingly used to diagnose breast lesions...
  52. PATHOPHYSIOLOGY OF EXPERIMENTAL AND HUMAN TUMORS
    Rakesh Jain; Fiscal Year: 1999
    ..interstitial pressure is an important prognostic factor for tumor treatment and for tumor localization during needle biopsy will be tested in human tumors, both in situ and grown as xenografts...
  53. MAGNETIC RESONANCE STUDIES OF BONE MARROW HEMATOPOIESIS
    Douglas Ballon; Fiscal Year: 2002
    ..The proposed assay will be designed to complement information obtained from the needle biopsy by providing a measure of the spatial extent of disease, particularly at sites inaccessible to the needle ..
  54. MAGNETIC RESONANCE STUDIES OF BONE MARROW HEMATOPOIESIS
    Douglas Ballon; Fiscal Year: 2003
    ..The proposed assay will be designed to complement information obtained from the needle biopsy by providing a measure of the spatial extent of disease, particularly at sites inaccessible to the needle ..
  55. Engineering Myoblasts for Transplantation
    EDWARD KISLAUSKIS; Fiscal Year: 2004
    ..are a resident population of muscle stem cells that can be harvested from virtually any patient with a simple needle biopsy. These cells can be expanded in vitro and then reintroduced in vivo to either repair tissues such as damaged ..
  56. EFFECTS OF DIABETIC CONTROL ON RENAL DISEASE
    Jose Barbosa; Fiscal Year: 1990
    ..Volunteers undergo a needle biopsy of the graft at transplant time, and randomized to stringent or standard glucose control, monitored ..
  57. Integrated Microchips for Informative Diagnosis of Cancer-immune Interactions
    Rong Fan; Fiscal Year: 2009
    ..a large protein biomarker panel from tissue sample sizes varying from a finger prick of blood or a skinny needle biopsy, to a single cell...
  58. DIGITAL MAMMOGRAPHY FOR STEREOTACTIC NEEDLE PLACEMENT
    MILTON STOLLER; Fiscal Year: 1991
    The proposed plan is for the development of a needle biopsy and needle localization device that can be used with existing mammographic equipment...
  59. Confocal DNA Cytometry Prostate Cancer- Age & Ethnicity
    William Grizzle; Fiscal Year: 2003
    ..In all age groups, predicting the biological aggressiveness and stage of tumors, based on needle biopsy findings and/or on the results of radical specimens, is critical for clinical decision making...
  60. AQUA: A New Quantitative in situ Proteomic Assay
    David Rimm; Fiscal Year: 2004
    ..be breast cancer since there are already 3 biospecific therapies and more are in the pipeline and since core needle biopsy is the most common current method for assessment of breast masses...
  61. PHASE I STUDY OF COMBINED VIRAL & SUICIDE GENE THERAPIES
    SVEND FREYTAG; Fiscal Year: 2000
    ..and by assessing the presence of tumor by digital rectal exam (DRE), transrectal ultrasound (TRUS), and needle biopsy of the prostate. This research may lead to a safe and effective therapy for men with localized prostate cancer...
  62. Randomized Trial of EUS Neurolysis in Pancreas Cancer
    Michael Wallace; Fiscal Year: 2006
    ..The primary outcome will be a reduction in pain at 1 month. Secondary outcomes will include the durability of pain control, quality of life, narcotic use and narcotic side effects. [unreadable] [unreadable]..