biopsy

Summary

Summary: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Top Publications

  1. ncbi Nonalcoholic fatty liver disease
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    N Engl J Med 346:1221-31. 2002
  2. ncbi A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Chun Tao Wai
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 38:518-26. 2003
  3. doi EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease
    Axel Heidenreich
    Department of Urology, RWTH University Aachen, Aachen, Germany
    Eur Urol 59:61-71. 2011
  4. ncbi Celiac disease
    Peter H R Green
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    N Engl J Med 357:1731-43. 2007
  5. doi CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
    T T Seppälä
    Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland
    Neurology 78:1568-75. 2012
  6. pmc T1 Mapping in cardiomyopathy at cardiac MR: comparison with endomyocardial biopsy
    Christopher T Sibley
    Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Department of Health and Human Services, 10 Center Dr, Building 10, MSC 1182, Bethesda, MD 20892 1182, USA
    Radiology 265:724-32. 2012
  7. pmc Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, 10098 Berlin, Germany
    J Clin Microbiol 43:3380-9. 2005
  8. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
  9. doi Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial
    Richard T Scott
    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
    Fertil Steril 100:697-703. 2013
  10. ncbi Nonalcoholic steatohepatitis: definition and pathology
    E M Brunt
    Department of Pathology, 4th Floor, Saint Louis University Hospital, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 21:3-16. 2001

Detail Information

Publications394 found, 100 shown here

  1. ncbi Nonalcoholic fatty liver disease
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    N Engl J Med 346:1221-31. 2002
  2. ncbi A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Chun Tao Wai
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 38:518-26. 2003
    ..Consecutive treatment-naive CHC patients who underwent liver biopsy over a 25-month period were divided into 2 sequential cohorts: training set (n = 192) and validation set (n = 78)...
  3. doi EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease
    Axel Heidenreich
    Department of Urology, RWTH University Aachen, Aachen, Germany
    Eur Urol 59:61-71. 2011
    ..Our aim was to present a summary of the 2010 version of the European Association of Urology (EAU) guidelines on the screening, diagnosis, and treatment of clinically localised cancer of the prostate (PCa)...
  4. ncbi Celiac disease
    Peter H R Green
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    N Engl J Med 357:1731-43. 2007
  5. doi CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
    T T Seppälä
    Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland
    Neurology 78:1568-75. 2012
    To assess the relationship between Alzheimer disease (AD)-related pathologic changes in frontal cortical brain biopsy and AD biomarkers in ventricular vs lumbar CSF, and to evaluate the relationships of AD biomarkers in CSF and cortical ..
  6. pmc T1 Mapping in cardiomyopathy at cardiac MR: comparison with endomyocardial biopsy
    Christopher T Sibley
    Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Department of Health and Human Services, 10 Center Dr, Building 10, MSC 1182, Bethesda, MD 20892 1182, USA
    Radiology 265:724-32. 2012
    To determine the utility of cardiac magnetic resonance (MR) T1 mapping for quantification of diffuse myocardial fibrosis compared with the standard of endomyocardial biopsy.
  7. pmc Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, 10098 Berlin, Germany
    J Clin Microbiol 43:3380-9. 2005
    The composition and spatial organization of the mucosal flora in biopsy specimens from patients with inflammatory bowel disease (IBD; either Crohn's disease or ulcerative colitis), self-limiting colitis, irritable-bowel syndrome (IBS), ..
  8. ncbi Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study
    F Imbert-Bismut
    Department of Biochemistry, , Paris, France
    Lancet 357:1069-75. 2001
    BACKGROUND: Liver biopsy is thought mandatory for management of patients with hepatitis C virus (HCV) infection, especially for staging fibrosis...
  9. doi Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial
    Richard T Scott
    Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA
    Fertil Steril 100:697-703. 2013
    To determine whether blastocyst biopsy and rapid quantitative real-time polymerase chain reaction (qPCR)-based comprehensive chromosome screening (CCS) improves in vitro fertilization (IVF) implantation and delivery rates.
  10. ncbi Nonalcoholic steatohepatitis: definition and pathology
    E M Brunt
    Department of Pathology, 4th Floor, Saint Louis University Hospital, 3635 Vista Ave, St Louis, MO 63110, USA
    Semin Liver Dis 21:3-16. 2001
    ..clinical evaluation nor laboratory values can ensure either the diagnosis or the exclusion of NASH, and liver biopsy interpretation continues to be considered the "gold standard" for diagnosis...
  11. doi Screening and prostate-cancer mortality in a randomized European study
    Fritz H Schroder
    Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands
    N Engl J Med 360:1320-8. 2009
    ..The European Randomized Study of Screening for Prostate Cancer was initiated in the early 1990s to evaluate the effect of screening with prostate-specific-antigen (PSA) testing on death rates from prostate cancer...
  12. doi The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification
    Daniel C Cattran
    University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada
    Kidney Int 76:534-45. 2009
    ..rigorous statistical analysis even after taking into account all clinical indicators available at the time of biopsy as well as during follow-up...
  13. pmc Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
    ..Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM...
  14. ncbi Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model
    Xavier Forns
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Catalonia, Spain
    Hepatology 36:986-92. 2002
    Liver biopsy is required for staging hepatic fibrosis in patients with chronic hepatitis C, but it is an expensive procedure with occasional complications and poor patient acceptance...
  15. doi Circulating tumor cells: liquid biopsy of cancer
    Catherine Alix-Panabieres
    Laboratory of Rare Human Circulating Cells, Institute of Research in Biotherapy, University Medical Centre, Saint Eloi Hospital, Montpellier, France
    Clin Chem 59:110-8. 2013
    ....
  16. ncbi Mucosal flora in inflammatory bowel disease
    Alexander Swidsinski
    Innere Klinik, Gastroenterologie, Charité Humboldt Universität, Berlin, Germany
    Gastroenterology 122:44-54. 2002
    ..Microorganisms that directly interact with the intestinal mucosa are obscured by fecal flora and poorly characterized...
  17. pmc Type I interferon: potential therapeutic target for psoriasis?
    Yihong Yao
    MedImmune, Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 3:e2737. 2008
    ..To better understand the pathogenesis of this disease and identify potential mediators, we used whole genome array analysis to profile paired lesional and nonlesional psoriatic skin and skin from healthy donors...
  18. doi Contemporary role of prostate cancer antigen 3 in the management of prostate cancer
    Marco Auprich
    Department of Urology, Medical University of Graz, Graz, Austria
    Eur Urol 60:1045-54. 2011
    ..Newly discovered biomarkers ideally should prove clinical usefulness, provide additional detection, staging, and prognosis information to improve individual risk assessment, and potentially permit targeted cancer therapy...
  19. doi Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6
    Sanjay Mukhopadhyay
    Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Am J Surg Pathol 35:15-25. 2011
    ..Thirty-nine cases of NSCLC that could not be further classified on biopsy and had subsequent resection specimens were identified...
  20. ncbi A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen
    Serge J Smeets
    Department of Otolaryngology Head Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 121:2465-72. 2007
    ....
  21. ncbi Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng/ml or lower
    Ian M Thompson
    Department of Urology, University of Texas Health Science Center at San Antonio, TX 78229, USA
    JAMA 294:66-70. 2005
    ..Three fourths of US men older than 50 years have been screened with prostate-specific antigen (PSA) for prostate cancer...
  22. doi Efficacy of rituximab in 164 patients with biopsy-proven lupus nephritis: pooled data from European cohorts
    Candido Diaz-Lagares
    Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Autoimmun Rev 11:357-64. 2012
    To present a pooled analysis of the efficacy of rituximab from European cohorts diagnosed with biopsy-proven lupus nephropathy (LN) who were treated with rituximab.
  23. ncbi AGA technical review on nonalcoholic fatty liver disease
    Arun J Sanyal
    Department of Internal Medicine Virginia Commonwealth University Medical College of Virginia Richmond, Virginia, USA
    Gastroenterology 123:1705-25. 2002
  24. ncbi Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    Vlad Ratziu
    Service d Hepatogastroenterologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Gastroenterology 128:1898-906. 2005
    ..The aim of this study was to assess the sampling error of liver biopsy and its impact on the diagnosis and staging of NASH.
  25. ncbi EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy
    G Lauria
    Immunology and Muscular Pathology Unit, Department of Clinical Neurosciences, National Neurological Institute Carlo Besta, Milan, Italy
    Eur J Neurol 12:747-58. 2005
    Skin biopsy has become a widely used tool to investigate small calibre sensory nerves including somatic unmyelinated intraepidermal nerve fibres (IENF), dermal myelinated nerve fibres, and autonomic nerve fibres in peripheral neuropathies ..
  26. ncbi Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens
    Rachel Ruckdeschel Smith
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:896-908. 2007
    ..Ex vivo expansion of resident cardiac stem cells, followed by delivery to the heart, may favor regeneration and functional improvement...
  27. doi The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility
    Ian S D Roberts
    Department of Cellular Pathology, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Kidney Int 76:546-56. 2009
    ..Our methodology, translating a strong evidence-based dataset into a working format, is a model for developing classifications of other types of renal disease...
  28. doi Long-term follow-up of biopsy-proven viral myocarditis: predictors of mortality and incomplete recovery
    Stefan Grün
    Department of Cardiology, Robert Bosch Medical Center, Auerbachstrasse 110, Stuttgart, Germany
    J Am Coll Cardiol 59:1604-15. 2012
    ..This study sought to evaluate the long-term mortality in patients with viral myocarditis, and to establish the prognostic value of various clinical, functional, and cardiovascular magnetic resonance (CMR) parameters...
  29. pmc New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort
    Robert K Nam
    Division of Urology, Sunnybrook Research Institute, University of Toronto, ON, Canada
    Cancer Biol Ther 12:997-1004. 2011
    ..To identify and examine polymorphisms of genes associated with aggressive and clinical significant forms of prostate cancer among a screening cohort...
  30. doi Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification
    Maxime Ronot
    Department of Radiology, Hôpital Beaujon Clichy, France INSERM U773, Centre de recherche Biomedicale Bichat Beaujon, Paris, France
    Hepatology 53:1182-91. 2011
    ..Magnetic resonance imaging (MRI) is considered the most informative imaging modality and liver biopsy a key diagnostic tool whose role in HCA subtyping has never been extensively studied...
  31. ncbi Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
    Timothy G St Pierre
    School of Physics, University of Western Australia, Perth, Australia
    Blood 105:855-61. 2005
    ..Currently, chemical analysis of needle biopsy specimens is the most common accepted method of measurement...
  32. ncbi Characterization of the limbal epithelial stem cell niche: novel imaging techniques permit in vivo observation and targeted biopsy of limbal epithelial stem cells
    Alex J Shortt
    MRC Clinical Research Fellow, Institute of Ophthalmology and Moorfields Eye Hospital, 11 43 Bath Street, London, EC1V 9EL, United Kingdom
    Stem Cells 25:1402-9. 2007
    ..Finally, the concept of targeted biopsy of adult SC niches improves stem cell yield and may prove to be essential for the successful development of novel ..
  33. ncbi Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease
    Yusheng Qiu
    Lung Pathology, Department of Gene Therapy, Imperial College, Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 168:968-75. 2003
    ..Thus, in COPD, in addition to CXCL8 and CXCR1, CXCL5 and CXCR2 appear to play important roles in the airway neutrophilia characteristic of severe exacerbations...
  34. pmc A subpopulation of CD163-positive macrophages is classically activated in psoriasis
    Judilyn Fuentes-Duculan
    Laboratory for Investigative Dermatology, Rockefeller University, New York, New York 10065, USA
    J Invest Dermatol 130:2412-22. 2010
    ..We conclude that macrophages are likely to contribute to the pathogenic inflammation in psoriasis, a prototypical T helper 1 (Th1) and Th17 disease, by releasing key inflammatory products...
  35. pmc Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease
    Mirella Fraquelli
    Second Division of Gastroenterology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Gut 56:968-73. 2007
    ..This study investigated these aspects...
  36. doi PCA3: a molecular urine assay for predicting prostate biopsy outcome
    Ina L Deras
    Gen Probe, Inc, San Diego, California 92121, USA
    J Urol 179:1587-92. 2008
    ..We further characterized PCA3 performance in different groups of men and determined whether the PCA3 score could synergize with other clinical information to predict biopsy outcome.
  37. pmc Resection of hepatocellular carcinoma without preoperative tumor biopsy
    I Levy
    Department of Medicine, Toronto General Hospital, Toronto, Canada
    Ann Surg 234:206-9. 2001
    OBJECTIVE: To evaluate the need for a preoperative tumor biopsy of liver lesions suspicious for hepatocellular carcinoma (HCC)...
  38. doi Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B
    S U Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Aliment Pharmacol Ther 32:498-505. 2010
    ..Interquartile range/median value (IQR/M) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan...
  39. doi Microscopic colitis
    Darrell S Pardi
    Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 140:1155-65. 2011
    ..Diagnosis requires histologic analysis of colon biopsy samples in the appropriate clinical setting...
  40. ncbi Activation of the mucosal immune system in irritable bowel syndrome
    Vinton S Chadwick
    Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, New Zealand
    Gastroenterology 122:1778-83. 2002
    ..A role for the mucosal immune system in the pathogenesis of irritable bowel syndrome is suggested by its association with intestinal infections...
  41. ncbi Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
    ..7T (outer diameter 2.7 mm with a biopsy channel of 0.8 mm in diameter)...
  42. ncbi Comparison of endorectal magnetic resonance imaging, guided prostate biopsy and digital rectal examination in the preoperative anatomical localization of prostate cancer
    Michael Mullerad
    Departments of Urology and Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Urol 174:2158-63. 2005
    We compared the accuracy of endorectal magnetic resonance imaging (erMRI), transrectal ultrasound (TRUS) guided biopsy and digital rectal examination (DRE) for detecting the location of cancer in the prostate gland and seminal vesicles.
  43. ncbi The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD
    Paul Angulo
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 45:846-54. 2007
    ..A total of 733 patients with NAFLD confirmed by liver biopsy were divided into 2 groups to construct (n = 480) and validate (n = 253) a scoring system...
  44. doi Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes
    Anna Ludovica Fracanzani
    Department of Internal Medicine, Scientific Institute of Recovery and Cure Foundation IRCCS, Hospital Maggiore Policlinico, University of Milan, Milan, Italy
    Hepatology 48:792-8. 2008
    ..liver disease (NAFLD) and normal alanine aminotransferase (ALT) have a milder disease and should undergo liver biopsy. We reviewed the histological data of 458 Italian patients with NAFLD in whom liver biopsy was indicated by ..
  45. ncbi Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer
    Wendie A Berg
    American College of Radiology Imaging Network, 301 Merrie Hunt Drive, Lutherville, MD 21093, USA
    Radiology 233:830-49. 2004
    ..To prospectively assess accuracy of mammography, clinical examination, ultrasonography (US), and magnetic resonance (MR) imaging in preoperative assessment of local extent of breast cancer...
  46. doi Validation of the Oxford classification of IgA nephropathy
    Andrew M Herzenberg
    Division of Nephrology, Toronto General Hospital, University of Toronto, Ontario, Canada
    Kidney Int 80:310-7. 2011
    ..Further studies are needed to determine the relationship to the impact of treatment and to define the value of the mesangial hypercellularity score...
  47. pmc Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study
    Ariel E Feldstein
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Hepatology 50:1072-8. 2009
    Liver biopsy remains the gold standard for diagnosing nonalcoholic steatohepatitis (NASH)...
  48. doi Quantitative real-time PCR analysis of Mycobacterium leprae DNA and mRNA in human biopsy material from leprosy and reactional cases
    Nirmala Lini
    Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India
    J Med Microbiol 58:753-9. 2009
    ..assay to quantify the copy number of bacterial DNA and hsp18 mRNA from 47 leprosy patients using paraffin-embedded biopsy samples. The assay used was specific, sensitive and reproducible...
  49. doi Noninvasive assessment of liver fibrosis
    Stella M Martinez
    Liver Unit, Hospital Clinic, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer and CIBERehd Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain
    Hepatology 53:325-35. 2011
    Liver biopsy has long been an important tool for assessing the degree of liver fibrosis. Information on the presence and degree of liver fibrosis is useful before making therapeutic decisions or predicting disease outcomes...
  50. doi Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C
    Michael T Dill
    Department of Biomedicine, Hepatology Laboratory, University of Basel, Basel, Switzerland
    Gastroenterology 140:1021-31. 2011
    ..We investigated whether IL28B genotype determines the constitutive expression of ISGs in the liver and compared the abilities of ISG levels and IL28B genotype to predict treatment outcome...
  51. pmc Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers
    Dena Marrinucci
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Phys Biol 9:016003. 2012
    ..We have established a fluid phase biopsy approach that identifies circulating tumor cells (CTCs) without using surface protein-based enrichment and ..
  52. pmc Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers
    Jonas F Ludvigsson
    Department of Pediatrics, Orebro University Hospital, Orebro, Sweden
    BMC Gastroenterol 9:19. 2009
    Small intestinal biopsy with villous atrophy (VA) is the gold standard for the diagnosis of celiac disease (CD). We validated VA (Marsh 3) and small intestinal inflammation without VA (Marsh 1+2) in Swedish regional biopsy registers.
  53. pmc Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in north India
    Shailja Pande
    Division of Molecular Oncology, Institute of Cytology and Preventive Oncology, I 7, Sector 39, Noida 201301, India
    J Clin Microbiol 46:1060-6. 2008
    ..7, 67.7, and 63.3%, respectively) indicate a possible epidemiological linkage between Europe and India with regard to the dissemination of HPV-16 infections in India...
  54. ncbi Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens
    Giuseppe Zamboni
    Department of Pathology, University of Verona, Verona, Italy
    Virchows Arch 445:552-63. 2004
    ..Our intention was to establish key diagnostic criteria, define grades of severity and activity, identify features of potential subtypes and evaluate the diagnostic relevance of biopsy specimens.
  55. doi Prostate health index (phi) and prostate cancer antigen 3 (PCA3) significantly improve diagnostic accuracy in patients undergoing prostate biopsy
    Sisto Perdonà
    Urology Unit, IRCCS Fondazione G Pascale, Napoli, Italy
    Prostate 73:227-35. 2013
    ..We assessed the diagnostic performance of these biomarkers, alone or in combination, in men undergoing first prostate biopsy for suspicion of PCa.
  56. doi Lesion localization in patients with a previous negative transrectal ultrasound biopsy and persistently elevated prostate specific antigen level using diffusion-weighted imaging at three Tesla before rebiopsy
    Byung Kwan Park
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Invest Radiol 43:789-93. 2008
    ..To assess the use of diffusion-weighted imaging (DWI) at 3 Tesla (T) for lesion localization in patients with a high risk of prostate cancer before a rebiopsy...
  57. doi Patterns of renal disease in Cape Town South Africa: a 10-year review of a single-centre renal biopsy database
    Ikechi Okpechi
    Division of Nephrology and Hypertension, Groote Schuur Hospital and University of Cape Town, Observatory, 7925, Cape Town, South Africa
    Nephrol Dial Transplant 26:1853-61. 2011
    The patterns of glomerular diseases have been widely reported from different regional and national biopsy registries worldwide...
  58. doi Clinical experience with azoospermia: aetiology and chances for spermatozoa detection upon biopsy
    F Tüttelmann
    Institute of Human Genetics, University of Munster, Munster, Germany Department of Andrology, Centre of Reproductive Medicine and Andrology, University of Munster, Munster, Germany
    Int J Androl 34:291-8. 2011
    ..Receiver-operating characteristic curves for chances of finding spermatozoa by testicular biopsy were calculated for testicular volume, serum follicle-stimulating hormone (FSH) and the seminal markers α-..
  59. ncbi Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease: a biopsy-proven European multicentre study
    Pekka Collin
    Tampere University Hospital and University of Tampere, Finland
    Eur J Gastroenterol Hepatol 17:85-91. 2005
    ..The setting allowed a further comparison between the antibody results and the conventional small-intestinal histology...
  60. pmc Association of [-2]proPSA with biopsy reclassification during active surveillance for prostate cancer
    Jeffrey J Tosoian
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 188:1131-6. 2012
    ..Thus, we examined the relationship between [-2]proPSA and biopsy results in men enrolled in an active surveillance program.
  61. ncbi Presentation, patterns of myocardial damage, and clinical course of viral myocarditis
    Heiko Mahrholdt
    Division of Cardiology, Robert Bosch Medical Center, Auerbachstrasse 110, 70376 Stuttgart, Germany
    Circulation 114:1581-90. 2006
    Enteroviruses and adenoviruses have been considered the most common causes of viral myocarditis, but parvovirus B19 (PVB19) and human herpesvirus 6 (HHV6) are increasingly found in endomyocardial biopsy samples.
  62. doi Predicting prostate biopsy outcome: prostate health index (phi) and prostate cancer antigen 3 (PCA3) are useful biomarkers
    Matteo Ferro
    Department of Urology, University of Naples Federico II, Naples, Italy
    Clin Chim Acta 413:1274-8. 2012
    Indication for prostate biopsy is presently mainly based on prostate-specific antigen (PSA) serum levels and digital-rectal examination (DRE)...
  63. pmc A viral discovery methodology for clinical biopsy samples utilising massively parallel next generation sequencing
    Gordon M Daly
    Department of Veterinary Medicine, The University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e28879. 2011
    Here we describe a virus discovery protocol for a range of different virus genera, that can be applied to biopsy-sized tissue samples...
  64. pmc Angiogenesis-independent tumor growth mediated by stem-like cancer cells
    Per Ø Sakariassen
    NorLux NeuroOncology, Department of Biomedicine, University of Bergen, N 5020 Bergen, Norway
    Proc Natl Acad Sci U S A 103:16466-71. 2006
    ..This article underlines the need for developing therapies that specifically target the stem-like cell pools in tumors...
  65. pmc Serum progranulin as an independent marker of liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease
    Yusuf Yilmaz
    Department of Gastroenterology, Marmara University, School of Medicine, Istanbul, Turkey
    Dis Markers 31:205-10. 2011
    ..We sought to determine whether serum progranulin levels are altered in patients with biopsy-proven NAFLD and if they are associated with their clinical, biochemical, and histological characteristics.
  66. doi Accuracy in celiac disease diagnostics by controlling the small-bowel biopsy process
    Charlotta Webb
    Department of Pediatrics, Lund University, Lund, Sweden
    J Pediatr Gastroenterol Nutr 52:549-53. 2011
    ....
  67. ncbi Regression of IgA nephropathy: a repeat biopsy study
    Osamu Hotta
    Department of Nephrology, Sendai Shakaihoken Hospital, Sendai, Japan
    Am J Kidney Dis 39:493-502. 2002
    ..To elucidate the reversibility of established IgA nephropathy, we performed a repeat biopsy study...
  68. doi Diagnosis of hepatocellular carcinoma: role of tumor markers and liver biopsy
    Stevan A Gonzalez
    Division of General and Transplant Hepatology, Baylor Regional Transplant Institute, Baylor All Saints Medical Center at Fort Worth, Baylor University Medical Center at Dallas, 1250 8th Avenue, Suite 515, Fort Worth, TX 76104, USA
    Clin Liver Dis 15:297-306, vii-x. 2011
    ..The use of serum tumor markers and biopsy are particularly important for diagnosis of small hepatic lesions with atypical features on imaging studies...
  69. ncbi Sampling variability of liver fibrosis in chronic hepatitis C
    Pierre Bedossa
    Service d Anatomie Pathologique, Hopital Bicetre, Le Kremlin Bicetre, France
    Hepatology 38:1449-57. 2003
    Fibrosis is a common endpoint of clinical trials in chronic hepatitis C, and liver biopsy remains the gold standard for fibrosis evaluation. However, variability in the distribution of fibrosis within the liver is a potential limitation...
  70. pmc Discordance between liver biopsy and Fibroscan® in assessing liver fibrosis in chronic hepatitis b: risk factors and influence of necroinflammation
    Seung Up Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    PLoS ONE 7:e32233. 2012
    Few studies have investigated predictors of discordance between liver biopsy (LB) and liver stiffness measurement (LSM) using FibroScan®...
  71. ncbi The natural history of low-grade ductal carcinoma in situ of the breast in women treated by biopsy only revealed over 30 years of long-term follow-up
    Melinda E Sanders
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 5310, USA
    Cancer 103:2481-4. 2005
    ..At the time the biopsies in the current study were originally examined, small DCIS was not diagnosed and, by default, these women were treated by biopsy only.
  72. ncbi Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection
    Susan Stewart
    International Society for Heart and Lung Transplantation, Addison, Texas, USA
    J Heart Lung Transplant 24:1710-20. 2005
    ..of the International Society for Heart and Lung Transplantation (ISHLT), a multidisciplinary review of the cardiac biopsy grading system was undertaken to address challenges and inconsistencies in its use and to address recent advances ..
  73. ncbi Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease
    Muhammed Hadithi
    Department of Gastroenterology, Het Groene Hart Ziekenhuis, Gouda, The Netherlands
    Ann Intern Med 147:294-302. 2007
    ..Estimates of the diagnostic performance of serologic testing and HLA-DQ typing for detecting celiac disease have mainly come from case-control studies...
  74. ncbi The histopathology of coeliac disease: time for a standardized report scheme for pathologists
    G Oberhuber
    Department of Clinical Pathology, University of Vienna, Medical School, Austria
    Eur J Gastroenterol Hepatol 11:1185-94. 1999
    ..The most important histological differential diagnoses are given, as well as a definition of the different clinical forms of coeliac disease such as symptomatic, silent, latent, potential, treated and refractory coeliac disease...
  75. ncbi Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliter
    Ian M Thompson
    Division of Urology, Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Tex, USA
    N Engl J Med 350:2239-46. 2004
    ..We investigated the prevalence of prostate cancer among men in the Prostate Cancer Prevention Trial who had a PSA level of 4.0 ng per milliliter or less...
  76. pmc A comparison of four fibrosis indexes in chronic HCV: development of new fibrosis-cirrhosis index (FCI)
    Waqar Ahmad
    Applied and Functional Genomics lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore 53700, Pakistan
    BMC Gastroenterol 11:44. 2011
    ..Hepatitis C can lead to liver fibrosis and cirrhosis. We compared readily available non-invasive fibrosis indexes for the fibrosis progression discrimination to find a better combination of existing non-invasive markers...
  77. doi 1H MR spectroscopy and diffusion-weighted imaging of the breast: are they useful tools for characterizing breast lesions before biopsy?
    Mitsuhiro Tozaki
    Division of Diagnostic Imaging, Breast Center, Kameda Medical Center, 929 Higashi Cho, Kamogawa, Chiba 296 8602, Japan
    AJR Am J Roentgenol 193:840-9. 2009
    The objective of our study was to determine whether proton ((1)H) MR spectroscopy (MRS) and diffusion-weighted imaging might be useful tools for characterizing breast lesions before biopsy.
  78. doi Optical biopsy of human bladder neoplasia with in vivo confocal laser endomicroscopy
    Geoffrey A Sonn
    Department of Urology, Stanford University School of Medicine, Stanford, California 94305 5118, USA
    J Urol 182:1299-305. 2009
    ..We evaluated confocal laser endomicroscopy by imaging normal, malignant appearing and indeterminate bladder mucosa in a pilot study...
  79. ncbi Functionally significant renal allograft rejection is defined by transcriptional criteria
    Steven C Hoffmann
    Transplantation Branch, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, USA
    Am J Transplant 5:573-81. 2005
    ..Quantitative analysis of selected gene transcripts may enhance the clinical assessment of allografts...
  80. doi Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis
    Diana Joka
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 55:455-64. 2012
    ..Despite various shortcomings, disease severity is generally determined by liver biopsy, emphasizing the need for simple noninvasive methods for assessing disease activity...
  81. doi Predictors of outcome in patients with suspected myocarditis
    Ingrid Kindermann
    Universitatsklinikum des Saarlandes, Klinik fur Innere Medizin III, Homburg Saar, Germany
    Circulation 118:639-48. 2008
    The objective of this study was to identify the prognostic indicators in patients with suspected myocarditis who underwent endomyocardial biopsy.
  82. doi TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin
    Ainara Castellanos-Rubio
    Endocrinology, Diabetes and Nutrition Research Group, Immunogenetics Laboratory, Hospital de Cruces, Bizkaia, Spain
    Autoimmunity 42:69-73. 2009
    ....
  83. pmc Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    Shironjit K Saha
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:685-91. 2008
    ..The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined...
  84. doi Prostate stem cell antigen mRNA expression in preoperatively negative biopsy specimens predicts subsequent cancer after transurethral resection of the prostate for benign prostatic hyperplasia
    Zhigang Zhao
    Department of Urology, The Second Affiliated Hospital, Shantou University Medical College, Guangdong Province, China
    Prostate 69:1292-302. 2009
    ..This study was to determine whether PSCA mRNA positivity in preoperatively negative prostatic biopsy samples from BPH men with PSA > 4...
  85. ncbi Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases
    B Coco
    UO Gastroenterologia ed Epatologia Ospedaliera, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
    J Viral Hepat 14:360-9. 2007
    ....
  86. ncbi Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C
    Laurent Castera
    Service d Hepato Gastroenterologie, Hopital Haut Leveque, C H U Bordeaux, Pessac, France
    Gastroenterology 128:343-50. 2005
    ..with and combined with currently available biochemical markers (Fibrotest; Biopredictive; and the aspartate transaminase to platelets ratio index [APRI]); a liver biopsy examination performed the same day served as the reference.
  87. doi Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnosti
    J D England
    American Academy of Neurology, St Paul, MN 55116, USA
    Neurology 72:177-84. 2009
    ..the evaluation of this disorder is not standardized, the available literature was reviewed to provide evidence-based guidelines regarding the role of autonomic testing, nerve biopsy, and skin biopsy for the assessment of polyneuropathy.
  88. ncbi Diagnostic value of systematic biopsy methods in the investigation of prostate cancer: a systematic review
    Klaus Eichler
    Horten Centre, Zurich University, Zurich, Switzerland
    J Urol 175:1605-12. 2006
    Several new extended prostate biopsy schemes (greater than 6 cores) have been proposed...
  89. ncbi Nonalcoholic fatty liver disease: a review of current understanding and future impact
    Michael Charlton
    Department of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 2:1048-58. 2004
    ..Liver biopsy is, however, required to accurately grade and stage NAFLD histologically...
  90. doi Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans
    Andrew S Flett
    Department of Medicine, University College London Hospitals National Health Service Trust, The Heart Hospital, 16 18 Westmoreland St, London W1G 8PH, United Kingdom
    Circulation 122:138-44. 2010
    ..Currently, quantifying diffuse myocardial fibrosis requires invasive biopsy, with inherent risk and sampling error...
  91. doi A biomedical engineering approach to mitigate the errors of prostate biopsy
    Hashim Uddin Ahmed
    Division of Surgery and Interventional Science, 4th Floor, Medical School Building, University College London, 74 Huntley Street, London WC1E 6AU, UK
    Nat Rev Urol 9:227-31. 2012
    ..involves serum PSA testing followed by sampling of the prostate using a transrectal ultrasonography (TRUS)-guided biopsy. Many specialists have discussed how PSA screening has contributed to underdetection of clinically significant ..
  92. ncbi In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    Anna Wieckowska
    Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hepatology 44:27-33. 2006
    In patients with nonalcoholic fatty liver disease (NAFLD), a liver biopsy remains the only reliable way to differentiate simple steatosis from nonalcoholic steatohepatitis (NASH). Noninvasive methods are urgently needed...
  93. doi Loss of heterozygosities in Barrett esophagus, dysplasia, and adenocarcinoma detected by esophageal brushing cytology and gastroesophageal biopsy
    Xiaoqi Lin
    Department of Pathology, Northwestern University, 251 East Huron Street, Chicago, IL 60611, USA
    Cancer 117:57-66. 2009
    Esophageal brushing cytology (EBC) and gastroesophageal biopsy (GEB) are complementary procedures for the evaluation of gastroesophageal lesions that help guide surveillance and treatment.
  94. pmc Effects of liver biopsy sample length and number of readings on sampling variability in nonalcoholic Fatty liver disease
    Raj Vuppalanchi
    Indiana University School of Medicine, Indianapolis, Indiana 46202 2859, USA
    Clin Gastroenterol Hepatol 7:481-6. 2009
    Liver biopsy is required to diagnose nonalcoholic steatohepatitis (NASH) in patients with suspected non-alcoholic fatty liver disease (NAFLD); recent studies suggested significant sampling variability...
  95. doi Outcomes of small renal mass needle core biopsy, nondiagnostic percutaneous biopsy, and the role of repeat biopsy
    Michael J Leveridge
    Department of Urology, Queen s University, Kingston, Ontario, Canada
    Eur Urol 60:578-84. 2011
    Percutaneous needle core biopsy has become established in the management of small renal masses ≤ 4 cm (SRMs). Recent series have reported success rates of ≥ 80%. Nondiagnostic results continue to be problematic.
  96. pmc Role of colonoscopic biopsy in distinguishing between Crohn's disease and intestinal tuberculosis
    R Kirsch
    Department of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    J Clin Pathol 59:840-4. 2006
    ..The histological differential diagnosis of Crohn's disease and intestinal tuberculosis can be very challenging, as both are chronic granulomatous disorders with overlapping histological features...
  97. doi The impact of real-time elastography guiding a systematic prostate biopsy to improve cancer detection rate: a prospective study of 353 patients
    Marko Brock
    Department of Urology, Ruhr University Bochum, Marienhospital Herne, Herne, Germany
    J Urol 187:2039-43. 2012
    We evaluated whether real-time elastography guided biopsy improves prostate cancer detection compared to conventional systematic gray scale ultrasound guidance.
  98. doi Intra-tumoral budding in preoperative biopsy specimens predicts lymph node and distant metastasis in patients with colorectal cancer
    Olivier T Giger
    Clinical Pathology Division, University of Berne, Berne, Switzerland
    Mod Pathol 25:1048-53. 2012
    ..of colorectal cancer (so called peri-tumoral budding), but tumor buds can also be observed in small preoperative biopsy specimens...
  99. ncbi Leishmania spp. parasite isolation through inoculation of patient biopsy macerates in interferon gamma knockout mice
    Milton Adriano Pelli de Oliveira
    Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, Goiania, Goias, Brasil, 74605 050
    Rev Inst Med Trop Sao Paulo 52:83-8. 2010
    ..In this study we tested the inoculation of interferon gamma knockout (IFNgamma KO) mice with biopsy macerates from Leishmania-infected patients to increase the possibility of isolating parasites...
  100. doi Rationale for percutaneous biopsy and histologic characterisation of renal tumours
    Alessandro Volpe
    Department of Urology, University of Eastern Piedmont, Maggiore della Carita Hospital, Novara, Italy
    Eur Urol 62:491-504. 2012
    The use of percutaneous biopsy of renal tumours has been traditionally reserved for selected cases because of uncertainties regarding its safety, accuracy, and clinical utility...
  101. pmc Non-sequential narrow band imaging for targeted biopsy and monitoring of gastric intestinal metaplasia
    Rungsun Rerknimitr
    Department of Medicine, Chulalongkorn University, Bangkok 10310, Thailand
    World J Gastroenterol 17:1336-42. 2011
    ..To evaluate the efficacy of non-sequential narrow band imaging (NBI) for a better recognition of gastric intestinal metaplasia (GIM)...

Research Grants79

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..They will also have an eye exam. - Participants will provide a hair sample, a blood sample, and a skin biopsy. The hair will be collected from the back of the head, and the skin will be collected from the inside of the upper ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..They will also have an eye exam. - Participants will provide a hair sample, a blood sample, and a skin biopsy. The hair will be collected from the back of the head, and the skin will be collected from the inside of the upper ..
  3. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  4. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  5. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..Serial biopsy samples will be taken from the ischemic and nonischemic areas during I/R in dogs...
  6. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..We propose cross-sectional studies among CLD patients undergoing liver biopsy at UIC and the University of Chicago, to address these Specific Aims: 1...
  7. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..b>Biopsy studies and animal studies suggest that amyloid light chains cause oxidative stress leading to tissue damage or ..
  8. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..aspect of our hypothesis by conducting a retrospective analysis using banked serum, urine and/or liver biopsy samples from healthy, uninfected individuals and HCV-infected patients (responders and non-responders)...
  9. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..The biomarker levels will be that will be correlated with clinical data including liver biopsy, serological and laboratory data with an emphasis on hepatic injury severity, disease progression and outcome...
  10. Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma
    Warren S Warren; Fiscal Year: 2010
    ..up the cost of healthcare with unnecessary, expensive, and invasive procedures (including sentinel lymph node biopsy and systemic adjuvant therapy) and may make it impossible for the patient to obtain health or life insurance...
  11. Androgen Receptor Pathway and Risk of Hepatic Fibrosis in Hepatitis C
    DONNA LORRAINE WHITE; Fiscal Year: 2013
    ..g., 5[unreadable]-reductase 2 (SRD5A2)) are associated with risk of advanced biopsy-determined hepatic fibrosis in Caucasian males with chronic hepatitis C infection...
  12. Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic Links
    SHIKHA SEKSARIA SUNDARAM; Fiscal Year: 2013
    ..This will be investigated in children with biopsy proven NAFLD who will undergo sleep study and control subjects with OSA and/or hypoxemia...
  13. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..One week after this study, subjects will have a skeletal muscle biopsy from the thigh...
  14. Detection of Liver Fibrosis Using IVIM Diffusion and DCE MRI in HCV
    Bachir Taouli; Fiscal Year: 2013
    ..Most hepatologists still rely on liver biopsy findings in patients newly diagnosed with HCV, which enables the assessment of liver damage (fibrosis and ..
  15. Robot-Assisted MRI-Guided Prostate Biopsy
    Dan Stoianovici; Fiscal Year: 2010
    ..06-EB-101* Development of minimally-invasive image-guided systems, and target area (1) Improving the accuracy of biopsy sampling/staging of disease such as in the evaluation for prostate cancer, with a new instrument for MRI-guided ..
  16. Real-Time Optical Diagnosis of Inflammatory Bowel Disease using SFDI
    Sylvain Gioux; Fiscal Year: 2013
    ..care presently consists of visual examination through a color videoscope, with tissue appearance and color guiding biopsy and clinical decision making. Given that IBD has a prevalence of over 1...
  17. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    ..Such up-regulation of MRP2 was further demonstrated in vivo in chronic murine models of IBD and human intestinal biopsy tissues from patients with active CD or UC...
  18. IGF-1, bone turnover and response to teriparatide in premenopausal women with IOP
    Adi Cohen; Fiscal Year: 2013
    ..In our recently completed NIH-funded bone biopsy study of 64 premenopausal women with IOP, a subset had very low bone formation rates and significantly higher IGF-..
  19. Biomarker Reference Laboratory, EDRN
    William E Grizzle; Fiscal Year: 2010
    ..and antigen retrieval techniques on real time quantitative PCR will be determined;the ability to perform such analyses on fixed biopsy specimens and archival material would greatly enhance the development of markers of early detection.
  20. Adherent Escherichia coli and associated virulence genes in children with IBD
    Sandra C Kim; Fiscal Year: 2010
    ..coli, and E. coli - associated virulence factors from mucosal biopsy samples (a) in the ileum and different regions of the colon of children with Crohn's disease versus children ..
  21. Yale Autoimmunity Center of Excellence
    Kevan C Herold; Fiscal Year: 2013
    ..Lip biopsy samples will be analyzed for structure of tertiary lymphoid organs and their cellular content...
  22. Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor Patients
    Raymond P Perez; Fiscal Year: 2010
    ..S14 expression in adipocytes;and (2) to determine whether this dose suppresses S14 mRNA expression in tumor biopsy specimens of tumor types potentially sensitive to inhibition of lipogenesis...
  23. NAFLD in T2DM: Prevalence in Hispanics and Role of Treatment
    Kenneth Cusi; Fiscal Year: 2013
    ..insulin clamp;iii) total body fat by DXA, to assess the relationship between adiposity and liver fat;iv) a liver biopsy if they have a fatty liver (MRS) and a high-risk profile for NASH...
  24. Detection of Prostate Cancer Genomic Signatures in Blood
    Amin I Kassis; Fiscal Year: 2010
    ..affirmed by histopathologic characterization following an invasive transrectal, ultrasound-directed, prostatic biopsy. At presentation, the majority of these tumors are localized in the prostate and surgical removal/radiation of ..
  25. PET Imaging Agent for Diabetes Mellitus
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..enable earlier and better diagnosis/management of both TIDM and T2DM since pancreas is not an ideal organ for biopsy. Several groups have described non- invasive imaging approaches to detect and follow loss of BCM...
  26. Mediators of Lithium Action in Olfactory Epithelium
    Evaristus A Nwulia; Fiscal Year: 2013
    ..In this study, we propose use of olfactory epithelium (OE) via nasal biopsy, combined with novel laser-captured microdissection to elucidate molecular and cellular markers of prospectively-..
  27. Dysfunction of neurofilaments in disease: an iPS model of Giant Axonal Neuropathy
    BETHANY LESLIE JOHNSON-KERNER; Fiscal Year: 2012
    ..phenotype and do not develop giant axons as seen in the human disease;moreover, human MNs are not accessible to biopsy and subsequent culture...
  28. Optically-Guided Bladder Biopsy Using Polarized Elastic Scattering Spectroscopy
    FREDERICK GEORGE BARGOOT; Fiscal Year: 2010
    ..This is followed by biopsy and surgical intervention. The recurrence rate for bladder cancer after surgery is an onerous 50-70%...
  29. High-Tc susceptometer to monitor transfusional iron overload (NSR device)
    Gary M Brittenham; Fiscal Year: 2012
    ..explants from adult and pediatric patients undergoing liver transplantation and from clinically indicated liver biopsy;and (2) to prospectively validate the high-Tc susceptometer with results of biochemical analysis of tissue from ..
  30. A Molecular targeting agent for systemic radiotherapy of metastatic Prostate Canc
    Kevin P Maresca; Fiscal Year: 2010
    ..screening method of PSA levels in the blood is valuable for early detection, the confirmation by fine needle biopsy does not give a representative evaluation of the entire prostate or determine lymph node involvement...
  31. Developing Novel Serological Biomarkers for Autoimmune Liver Diseases
    Xuhang Li; Fiscal Year: 2013
    ..Disease diagnosis/prognosis relies heavily on clinical presentations as well as invasive and resource-consuming biopsy-based histopathology...
  32. The Role of Connexin32 in the Pathogensis of CMTX
    STEVEN SIMON SCHERER; Fiscal Year: 2013
    ..MRI paints the picture of profound dysmyelination, but this has yet to be confirmed in an autopsy or biopsy. In cellular and animal models, the mutants associated with PMLD impair GJ communication, but we do not yet know ..
  33. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2012
    ..The hypothesis is that OCT and OCM can function as a type of "optical biopsy" to visualize early neoplastic changes in vivo without excision and processing of specimens...
  34. Molecular Determinants Affecting FLT-PET in Colorectal Cancer
    HENRY C MANNING; Fiscal Year: 2010
    ..Furthermore, serial biopsy is required to assess treatment response longitudinally and is clinically impractical in many instances...
  35. Visceral Adiposity, HIV, and HCV: Biologic Mediators of Hepatic Steatosis
    Phyllis C Tien; Fiscal Year: 2013
    ..MRS studies a larger area than a random core biopsy of liver tissue, provides a continuous measure of liver fat, and allows for the study of patients with HIV ..
  36. Intra-operative confocal imaging to guide Mohs surgery
    Milind Rajadhyaksha; Fiscal Year: 2012
    ..with topically applied aluminum chloride to enhance cancer-to-normal tissue contrast, in surgically-exposed shave-biopsy wounds in situ on patients...
  37. Development and Validation of a Panel of Breast Cancer for the Early Diagnosis of
    FELIX RODOLFO FERNANDEZ MADRID; Fiscal Year: 2010
    ..antigen panel will be tested by probing the microarray with an existing collection of sera from women with biopsy-proven diagnosis of DCIS and, infiltrating ductal carcinoma (IDC) of the breast and complete follow up, including ..
  38. Scleroderma Subtyping from Fresh and Archived Biopsies using NextGen Sequencing
    Michael W Fanger; Fiscal Year: 2011
    ..Because SSc is a rare disease, skin biopsies are in high demand and longitudinal accrual of fresh biopsy samples for DNA microarray analysis is slow, which severely hampers clinical validation of the test...
  39. Neurotrophin-Secreting Muscle Stem Cell Therapy for Laryngeal Paralysis
    Stacey L Halum; Fiscal Year: 2013
    ..In fact, when this model is applied to humans, surgeries would be limited to a small skeletal muscle biopsy which can be derived under local anesthetic in the office, and a laryngeal injection, which is a procedure ..
  40. Urine biomarkers of lupus nephritis pathology and response to therapy
    James C Oates; Fiscal Year: 2013
    ..models of urine biomarkers diagnostic of International Society of Nephrology/Renal Pathology Society (ISN/RPS) biopsy class (Class) in lupus nephritis (LN), 2) Create and validate models of urine biomarkers predictive of renal ..
  41. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..The "gold standard" test for the assessment of allograft rejection is renal allograft biopsy, which is an invasive, expensive and relatively risky procedure...
  42. Phenotypes of diabetic kidney disease and the relationship to retinal pathology
    Amy Mottl; Fiscal Year: 2013
    ..research consists of a preliminary study to determine the feasibility of performing the gold standards of kidney biopsy, iohexol GFR measurement and retinal photography on type 2 diabetic participants...
  43. Validation and Development of WEE1 as a therapeutic target in AML
    Christopher C Porter; Fiscal Year: 2013
    ..stresses in myeloid progenitor cells and perform immunohistochemistry for Wee1 expression in AML bone marrow biopsy specimens...
  44. Brown Adipose Tissue Vasculature Probes for Non-Invasive Imaging
    Mikhail G Kolonin; Fiscal Year: 2011
    ..Most adults appear to have BAT revealed by biopsy, however it is often metabolically inactive in obese and aging individuals and is undetectable by PET...
  45. Chemoprevention of Colorectal Cancer by Aldose Reductase Inhibition
    Satish K Srivastava; Fiscal Year: 2013
    ..that mediate CRC cell growth/death;2) elucidate how AR inhibition prevents growth and metastasis of human CRC biopsy samples and colon cancer stem cells implanted in athymic nude mice;and 3) determine how AR inhibition prevents the ..
  46. Non-Classical Manifestations of Primary Hyperparathyroidism
    Shonni J Silverberg; Fiscal Year: 2013
    ..repletion in PHPT on static and dynamic histomorphometric parameters of bone remodeling (by quadruple labeled bone biopsy). Theme 2. Cardiovascular manifestations of PHPT: SA2a...
  47. Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRI
    Scott B Reeder; Fiscal Year: 2013
    ..Diagnosis of NAFLD is limited because it relies on biopsy, which is expensive, risky, and is highly variable for grading of steatosis...
  48. PSMA-based Cancer Imaging Agents
    Martin G Pomper; Fiscal Year: 2013
    ..e., PSA, digital rectal examination and biopsy. We believe that molecular imaging techniques, with their ability to interrogate receptor/enzyme/antigen/..
  49. Biomarker Prediction of Gleason Upgrading
    Bruce J Trock; Fiscal Year: 2010
    ..the ability to safely offer active surveillance as an alternative to immediate treatment depends on how well the biopsy can capture the phenotype of the tumor in the whole prostate...
  50. Targeting fibrocytes in Duchenne muscular dystrophy
    Lan Zhou; Fiscal Year: 2013
    ..Our preliminary study showed that fibrocytes were also present in a DMD patient muscle biopsy and in mdx diaphragm, the only skeletal muscle in mdx mice that undergoes progressive fibrosis...
  51. Fluorescein for Sentinel Lymph Node Detection
    James M McGreevy; Fiscal Year: 2012
    ..of its proprietary formulation of a fluorescent drug and new medical devices for Sentinel Lymph Node (SLN) biopsy for the surgical treatment of melanoma and breast cancer...
  52. Regulation of hepcidin and iron metabolism in liver disease
    Julia Goodnough; Fiscal Year: 2011
    ..hepcidin, HGF and GDF-15 values to chronic hepatitis C patient liver iron content (available from patient liver biopsy) and patient serum iron, ferritin measurements...
  53. Biomolecular Markers of Renal Allograft Status
    Thangamani Muthukumar; Fiscal Year: 2013
    ..AR and IF/TA are currently diagnosed using the invasive biopsy procedure. Development of noninvasive biomarkers of renal allograft status is an important goal...
  54. Biomarkers of Kidney Pathology
    Sushrut S Waikar; Fiscal Year: 2013
    ..describes a prospective cohort study involving biological sample collection from patients undergoing native kidney biopsy, the gold standard determination for identifying the cause(s) of CKD...
  55. Measurement of Renal Viscoelastic Properties with Ultrasound
    MATTHEW WILLIAM URBAN; Fiscal Year: 2013
    ..Renal biopsy is the gold standard for diagnosis of kidney health, but is an invasive procedure, can not be used frequently, and ..
  56. Validation of Biomarkers to Distinguish Aggressive from Indolent Prostate Cancer
    George Wilding; Fiscal Year: 2013
    ..PIN), localized low grade PCa, high grade PCa and metastatic PCa available at our Institution along with patient biopsy and prostatectomy samples obtained from the Marshfield Clinic, Marshfield, WI...
  57. The Role of Uncultivated Bacteria in Bacterial Vaginosis
    DAVID NEAL FREDRICKS; Fiscal Year: 2013
    ..The value of non-biopsy samples will be studied here...
  58. Novel prognostic microRNA biomarkers for primary sclerosing cholangitis
    Kris Kowdley; Fiscal Year: 2013
    ..The progression of PSC is commonly monitored by Endoscopic Retrograde Cholangiopancreatography (ERCP) and liver biopsy;invasive procedures associated with increased risk of serious complications...
  59. Effects of Macronutrients on Regulation of Endoplasmic Reticulum Stress in Human
    Guenther Boden; Fiscal Year: 2013
    ..of ER stress related proteins and on stress kinases and proinflammatory cytokines in sc adipose tissue biopsy samples obtained before and after these studies...
  60. Blood-based detection of BRAF DNA as a biomarker in metastatic melanoma patients
    David Polsky; Fiscal Year: 2012
    ..Currently, enrollment into clinical trials with PLX4032 is restricted to patients in whom a tumor biopsy can be obtained, and in which the mutation is detected...
  61. Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis
    Jayant A Talwalkar; Fiscal Year: 2010
    ..for this burden of disease is progressive hepatic fibrosis, which traditionally has been diagnosed by liver biopsy. However, the strict reliance on liver biopsy for detecting hepatic fibrosis is hampered by inherent problems ..
  62. EPIDEMIOLOGY OF HELICOBACTER PYLORI TRANSMISSION
    Julie Parsonnet; Fiscal Year: 2010
    ..pylori in the stomach will also be assessed with endoscopy and biopsy. How humans respond to the spectrum of chronic infections that they harbor is a question of critical importance to ..
  63. The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
    ROBERT STANLEY SHERWIN; Fiscal Year: 2012
    ..b>Biopsy-confirmed BAT in adult humans has revived interest in discovering whether dysfunction in regulation and/or ..
  64. Combined raman spectroscopy-optical tomagraphy for complete diagnosis of skin can
    Anita Mahadevan Jansen; Fiscal Year: 2009
    ..Current diagnostic methods for skin cancers rely on physical examination in conjunction with skin biopsy, methods that have limited accuracy in early diagnosis...
  65. Novel minimally invasive assessment of gastrointestinal inflammation in food alle
    Glenn Furuta; Fiscal Year: 2009
    ..Standard of care for EE includes initial endoscopy with biopsy for obtaining esophageal tissue to determine the numbers of eosinophils, =15/hpf being diagnostic...
  66. MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESS
    Dan Stoianovici; Fiscal Year: 2001
    ..The deliverable is an accurate mechanism for performing precise image-guided procedures such as biopsy, brachytherapy, cryosurgery, hyperthermia, interstitial laser therapy, focused ultrasound and microwaves, ..
  67. MULTI IMAGER COMPATIBLE ROBOT FOR PROSTATE ACCESS
    Dan Stoianovici; Fiscal Year: 2004
    ..The deliverable is an accurate mechanism for performing precise image-guided procedures such as biopsy, brachytherapy, cryosurgery, hyperthermia, interstitial laser therapy, focused ultrasound and microwaves, ..
  68. Noninvasive Diagnosis of Early Bladder Cancers with Optical Coherence Tomography
    Yingtian Pan; Fiscal Year: 2007
    ..g., bioMEMS, optical coherence tomography, and fluorescence endoscopy) will be used, thus allowing optical biopsy of early flat bladder cancers (e.g...
  69. MRI-BASED VIRTUAL BONE BIOPSY IN RENAL OSTEODYSTROPHY
    Felix Wehrli; Fiscal Year: 2001
    ..To date, bone biopsy is the only available tool for characterizing ROD...
  70. Raman spectroscopy probes for assisting stereotactic breast biopsy needle placeme
    Stephen Fulghum; Fiscal Year: 2009
    Stereotactic, large-core, needle biopsy using a prone biopsy table and guided by imaging, is now accepted as an alternative to open surgical biopsy for non-palpable breast lesions discovered by mammography...
  71. Zinc-Based Early Detection of Prostate Cancer
    Christopher J Frederickson; Fiscal Year: 2010
    ..79, .92, and .99 for detecting biopsy-confirmed prostatic adenocarcinoma...
  72. Prediction of Lupus Outcome by Gene Expression Patterns
    Robert Winchester; Fiscal Year: 2006
    ..is sought for performing mechanistic studies to define the gene expression profiles of glomeruli isolated from biopsy sections of lupus glomerulonephritis with the overall goals of determining whether the glomerular gene expression ..
  73. Decoy receptor 3 and liver cirrhosis
    Sunghee Kim; Fiscal Year: 2006
    ..Currently, liver biopsy is the gold standard in determining the presence of liver cirrhosis...
  74. PROTEOMICS AND HEPATITIS C: FIBROSIS AND PROGNOSIS
    Glenn Gourley; Fiscal Year: 2005
    ..in understanding the development of liver fibrosis in people with chronic hepatitis C which currently makes liver biopsy the best way to determine liver fibrosis...
  75. Diagnosing and monitoring NAFLD using unbound FFA profiles
    Alan Kleinfeld; Fiscal Year: 2009
    ..This has greatly hindered NAFLD research because biopsy-related expenses and the risk of medical complications make the widespread screening of at-risk populations ..
  76. CT fluoroscopy guided robotically assisted lung biopsy
    Kevin Cleary; Fiscal Year: 2005
    ..an existing robotic system to assist the physician in accurate computed tomography (CT) fluoroscopy-guided needle biopsy of lung nodules...
  77. Fluorescence Imaging for Sentinel Lymph Node Mapping
    Eva Sevick Muraca; Fiscal Year: 2003
    b>Biopsy of the sentinel lymph node provides a convenient prognostic indicator for breast cancer, melanoma, as well as other cancers...
  78. CT fluoroscopy guided robotically assisted lung biopsy
    Kevin Cleary; Fiscal Year: 2003
    ..an existing robotic system to assist the physician in accurate computed tomography (CT) fluoroscopy-guided needle biopsy of lung nodules...
  79. NonInvasive Optical Imaging of Vocal Cord Microstructure
    Brian Wong; Fiscal Year: 2004
    The diagnosis and management of many true vocal cord (TVC) lesions requires biopsy or excision which exposes the patient to the risks of general anesthesia, TVC injury, and potential iatrogenic glottic speech impairment...