glasgow outcome scale

Summary

Summary: A scale that assesses the outcome of serious craniocerebral injuries, based on the level of regained social functioning.

Top Publications

  1. ncbi Reliability of postal questionnaires for the Glasgow Outcome Scale
    J T L Wilson
    Department of Psychology, University of Stirling, Stirling, United Kingdom
    J Neurotrauma 19:999-1005. 2002
  2. ncbi Pressure reactivity as a guide in the treatment of cerebral perfusion pressure in patients with brain trauma
    Tim Howells
    Department of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    J Neurosurg 102:311-7. 2005
  3. ncbi Determinants of long-term functional consequences after major trauma
    Herman R Holtslag
    Department of Rehabilitation, University Medical Center, The Netherlands
    J Trauma 62:919-27. 2007
  4. ncbi Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study
    Adrian V Hernandez
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Neurotrauma 23:1295-303. 2006
  5. ncbi Functional outcome scales in traumatic brain injury: a comparison of the Glasgow Outcome Scale (Extended) and the Functional Status Examination
    Anne M Hudak
    Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9055, USA
    J Neurotrauma 22:1319-26. 2005
  6. ncbi Reliability of a telephone-based Glasgow Outcome Scale assessment using a structured interview in a heterogenous population of patients and examiners
    Scott A LeGrand
    Department of Anesthesia, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Neurotrauma 24:1437-46. 2007
  7. ncbi Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury
    Stefania Mondello
    University of Florida, Department of Anesthesiology, Gainesville, FL, USA
    Brain Inj 26:1629-35. 2012
  8. ncbi Outcome measures for traumatic brain injury
    Dhaval Shukla
    Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India
    Clin Neurol Neurosurg 113:435-41. 2011
  9. ncbi Relating quality of life to Glasgow outcome scale health states
    Jennifer Kosty
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 29:1322-7. 2012
  10. ncbi Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury
    Paul M Shore
    Department of Pediatrics, University of Texas Southwestern Medical Center, Division of Critical Care Services, Children s Medical Center of Dallas, 1935 Motor Street, Dallas, TX 73235, USA
    J Neurotrauma 24:75-86. 2007

Detail Information

Publications262 found, 100 shown here

  1. ncbi Reliability of postal questionnaires for the Glasgow Outcome Scale
    J T L Wilson
    Department of Psychology, University of Stirling, Stirling, United Kingdom
    J Neurotrauma 19:999-1005. 2002
    ..study was to investigate if a questionnaire sent by mail can give a reliable assessment of outcome on the Glasgow Outcome Scale. A questionnaire was developed for the Glasgow Outcome Scale (GOS) and a second questionnaire for the ..
  2. ncbi Pressure reactivity as a guide in the treatment of cerebral perfusion pressure in patients with brain trauma
    Tim Howells
    Department of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
    J Neurosurg 102:311-7. 2005
    ..One protocol was primarily oriented toward reducing intracranial pressure (ICP), and the other primarily on maintaining cerebral perfusion pressure (CPP)...
  3. ncbi Determinants of long-term functional consequences after major trauma
    Herman R Holtslag
    Department of Rehabilitation, University Medical Center, The Netherlands
    J Trauma 62:919-27. 2007
    ..The purpose of this study was to describe the long-term functional consequences from major trauma and to quantify the effect of sociodemographic, injury-related, and physical determinants of its outcome...
  4. ncbi Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study
    Adrian V Hernandez
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Neurotrauma 23:1295-303. 2006
    ..The primary outcome was the dichotomized Glasgow Outcome Scale at 6 months (favorable/unfavorable)...
  5. ncbi Functional outcome scales in traumatic brain injury: a comparison of the Glasgow Outcome Scale (Extended) and the Functional Status Examination
    Anne M Hudak
    Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9055, USA
    J Neurotrauma 22:1319-26. 2005
    ..The most widely used of these measures, the Glasgow Outcome Scale (GOS) and the GOS-Extended (GOS-E), have been criticized as suffering from ceiling effects...
  6. ncbi Reliability of a telephone-based Glasgow Outcome Scale assessment using a structured interview in a heterogenous population of patients and examiners
    Scott A LeGrand
    Department of Anesthesia, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Neurotrauma 24:1437-46. 2007
    A reliable telephone-based Glasgow Outcome Scale (GOS) assessment would be advantageous to both patients and investigators...
  7. ncbi Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury
    Stefania Mondello
    University of Florida, Department of Anesthesiology, Gainesville, FL, USA
    Brain Inj 26:1629-35. 2012
    ..To evaluate microtubule-associated proteins (MAP-2), a dendritic marker of both acute damage and chronic neuronal regeneration after injury, in serum of survivors after severe TBI and examine the association with long-term outcome...
  8. ncbi Outcome measures for traumatic brain injury
    Dhaval Shukla
    Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India
    Clin Neurol Neurosurg 113:435-41. 2011
    ..A few, commonly used are Glasgow Outcome Scale (GOS) with or without extended scores, Disability Rating Scale (DRS), Functional Independence Measure (FIM)..
  9. ncbi Relating quality of life to Glasgow outcome scale health states
    Jennifer Kosty
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 29:1322-7. 2012
    ..quality-of-life (QOL) values are available for intermediate outcomes, such as those described by the Glasgow Outcome Scale Extended (GOSE). Our objective was therefore to determine QOL for the health states described by the GOSE...
  10. ncbi Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury
    Paul M Shore
    Department of Pediatrics, University of Texas Southwestern Medical Center, Division of Critical Care Services, Children s Medical Center of Dallas, 1935 Motor Street, Dallas, TX 73235, USA
    J Neurotrauma 24:75-86. 2007
    The Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) are widely used clinical scoring systems to measure the severity of neurologic injury after traumatic brain injury (TBI), but have recognized limitations in infants and small ..
  11. ncbi Outcomes of early endovascular versus surgical treatment of ruptured cerebral aneurysms. A prospective randomized study
    T Koivisto
    Departments of Neurosurgery, Kuopio University Hospital, Kuopio, Finland
    Stroke 31:2369-77. 2000
    ..This prospective study was conducted to compare the outcomes of surgical clipping and endovascular treatment in acute (<72 hours) aneurysmal subarachnoid hemorrhage (SAH)...
  12. ncbi IL-6 polymorphism associated with fatal outcome in patients with severe traumatic brain injury
    André Luiz Dalla Libera
    Programa de Pós Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil ULBRA, Canoas, Brazil
    Brain Inj 25:365-9. 2011
    ....
  13. ncbi Prevalence and determinants of disabilities and return to work after major trauma
    Wouter J Vles
    Department of Surgery, St Elisabeth Hospital, Tilburg, The Netherlands
    J Trauma 58:126-35. 2005
    ..The purpose of this study was to assess the prevalence and determinants of disabilities and return to work after severe injury in a Dutch, Level I trauma center...
  14. ncbi Increased matrix metalloproteinase-9 in blood in association with activation of interleukin-6 after traumatic brain injury: influence of hypothermic therapy
    Eiichi Suehiro
    Department of Neurosurgery, Clinical Neuroscience, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    J Neurotrauma 21:1706-11. 2004
    ..The elevation of MMP-9 is associated with inflammatory events following TBI. Hypothermic intervention may suppress the elevation of MMP-9 with suppression of the inflammatory response, affording neuroprotection in TBI...
  15. ncbi Anxiety and depression after spontaneous subarachnoid hemorrhage
    Paul Graham Morris
    Section of Clinical and Health Psychology, University of Edinburgh, Edinburgh, Scotland
    Neurosurgery 54:47-52; discussion 52-4. 2004
    ..Relatively little attention has been paid to emotional outcome after subarachnoid hemorrhage (SAH). This study assessed levels of anxiety and depression among SAH survivors and related these to clinical indices...
  16. ncbi Glasgow Coma Scale, brain electric activity mapping and Glasgow Outcome Scale after hyperbaric oxygen treatment of severe brain injury
    H Ren
    Department of Neurosurgery, Second Affiliated Hospital, Lanzhou Medical Collage, Lanzhou 730030, China
    Chin J Traumatol 4:239-41. 2001
    ..alteration of clinic GCS (Glasgow Coma Scale), brain electric activity mapping (BEAM), prognosis and GOS (Glasgow Outcome Scale) before a nd after hyperbaric oxygen treatment...
  17. ncbi Basal ganglia haematomas in non-comatose patients: subacute stereotactic aspiration improves long-term outcome in comparison to purely medical treatment
    Gerhard Marquardt
    Neurosurgical Clinic, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528, Frankfurt am Main, Germany
    Neurosurg Rev 28:64-9. 2005
    ..Compared with medical patients, the median Glasgow Outcome Scale score was 1 point higher (P<0...
  18. ncbi Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy
    Gordon D Murray
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 22:511-7. 2005
    ..The approach raises issues of clinical, statistical, and regulatory importance, and we initiate what we believe needs to become a widespread debate amongst the community involved in clinical research in head injury and stroke...
  19. ncbi Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduction of hemorrhage volume and neurological improvement
    Paul Vespa
    University of California, Los Angeles, David Geffen School of Medicine, USA
    Neurocrit Care 2:274-81. 2005
    ..This is a phase-2 safety trial to demonstrate the ability of frameless stereotactic aspiration and thrombolysis of ICH to safely remove blood...
  20. ncbi Hybrid outcome prediction model for severe traumatic brain injury
    Boon Chuan Pang
    Acute Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, 11 Jalan Tan Tock Seng, 308433 Singapore
    J Neurotrauma 24:136-46. 2007
    ..Combining both logistic regression and decision tree models, a hybrid prediction model was then developed. This hybrid model would more accurately predict the 6-month post-severe head injury outcome using baseline admission parameters...
  21. ncbi The impact of aneurysmal subarachnoid hemorrhage on functional outcome
    Catherine J Kirkness
    University of Washington, Box 357266, Seattle, WA 98195 7266, USA
    J Neurosci Nurs 34:134-41. 2002
    ..This article describes outcome at 3 months after aneurysmal SAH in 61 patients, using the Extended Glasgow Outcome Scale (GOSE) and the Functional Status Examination (FSE)...
  22. ncbi Glasgow Coma Scale on admission is correlated with postoperative Glasgow Outcome Scale in chronic subdural hematoma
    Abbass Amirjamshidi
    Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Neurosci 14:1240-1. 2007
    To evaluate the correlation between admission Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) in chronic subdural hematoma (CSDH).
  23. ncbi Psychosocial functioning during the year following severe traumatic brain injury
    D A Kersel
    Department of Psychological Medicine, University of Glasgow, Scotland, UK
    Brain Inj 15:683-96. 2001
    ..There was also a significant and ongoing decrease in all five aspects of social and leisure activities...
  24. ncbi Predicting outcome after traumatic brain injury: development and validation of a prognostic score based on admission characteristics
    Chantal W P M Hukkelhoven
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    J Neurotrauma 22:1025-39. 2005
    ..evaluated mortality and unfavorable outcome, that is, death, and vegetative or severe disability on the Glasgow Outcome Scale (GOS), at 6 months post-injury...
  25. ncbi Epidemiology, severity classification, and outcome of moderate and severe traumatic brain injury: a prospective multicenter study
    Teuntje M J C Andriessen
    Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Neurotrauma 28:2019-31. 2011
    ..Our results confirm that TBI epidemiology and injury patterns have changed in recent years whereas case fatality rates remain high...
  26. ncbi Early Glasgow Outcome Scale scores predict long-term functional outcome in patients with severe traumatic brain injury
    Joseph T King
    Section of Neurosurgery, VA Connecticut Healthcare System 112, West Haven, Connecticut 06516, USA
    J Neurotrauma 22:947-54. 2005
    ..We examined the association between Glasgow Outcome Scale (GOS) assessed at 3 months and long-term outcomes at 12 months after TBI...
  27. ncbi Validity and sensitivity to change of the extended Glasgow Outcome Scale in mild to moderate traumatic brain injury
    H S Levin
    Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurotrauma 18:575-84. 2001
    Using a structured outcome interview, this study addressed the validity and sensitivity to change of the Glasgow Outcome Scale (GOS) and the Extended GOS (GOSE) in a prospective study of patients who sustained mild (n = 30) to moderate (..
  28. pmc Use of the Oxford Handicap Scale at hospital discharge to predict Glasgow Outcome Scale at 6 months in patients with traumatic brain injury
    Pablo Perel
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Med Res Methodol 8:72. 2008
    ..The Glasgow Outcome Scale (GOS) is the most widely used outcome measure in randomised controlled trials (RCTs) in TBI patients...
  29. ncbi Blood pressure and outcome after severe pediatric traumatic brain injury
    Monica S Vavilala
    Department of Anesthesiology, Harborview Medical Center, University of Washington, Seattle, USA
    J Trauma 55:1039-44. 2003
    ..We examined the relationship between age-appropriate systolic blood pressure (AASBP) percentile and outcome after severe pediatric TBI...
  30. ncbi Spectrin breakdown products in the cerebrospinal fluid in severe head injury--preliminary observations
    O Farkas
    Department of Neurosurgery, Center for Medical and Health Sciences, Pecs University, Pecs, Hungary
    Acta Neurochir (Wien) 147:855-61. 2005
    ....
  31. ncbi Association between interleukin-1 beta (IL-1beta) gene polymorphism and outcome after head injury: an early report
    M Uzan
    Department of Neurosurgery, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey
    Acta Neurochir (Wien) 147:715-20; discussion 720. 2005
    ..Therefore, the aim of this paper was to search for the possible association between the outcome and IL-1beta gene polymorphism in human HI...
  32. ncbi Intracranial hypertension: what additional information can be derived from ICP waveform after head injury?
    M Balestreri
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir (Wien) 146:131-41. 2004
    ..We have studied whether the value of ICP monitoring can be augmented by indices describing cerebrovascular pressure-reactivity and pressure-volume compensatory reserve derived from ICP and arterial blood pressure (ABP) waveforms...
  33. ncbi Hyperglycemia and outcomes from pediatric traumatic brain injury
    Amalia Cochran
    Department of Surgery, University of Utah, Salt Lake City, USA
    J Trauma 55:1035-8. 2003
    ..The clinical significance of hyperglycemia after pediatric traumatic brain injury is controversial. This study addresses the relationship between hyperglycemia and outcomes after traumatic brain injury in pediatric patients...
  34. ncbi Alteration in brain natriuretic peptide (BNP) plasma concentration following severe traumatic brain injury
    G E Sviri
    Department of Neurosurgery, Rambam Maimonides Medical Center, Technion Israel Institute of Technology, Haifa, Israel
    Acta Neurochir (Wien) 148:529-33; discussion 533. 2006
    ..The purpose of the present study was to evaluate trends in BNP plasma concentrations during the acute phase following severe (traumatic brain injury) TBI...
  35. ncbi Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury
    Craig D Winter
    Neurosurgical Department, Wessex Neurological Centre, Southampton, University Hospitals NHS Trust, School of Medicine, University of Southampton, SO16 7PX, UK
    Brain 127:315-20. 2004
    ..were assessed initially using the Glasgow coma score, and survivors were assessed after 6 months using the Glasgow outcome scale. Significantly (P = 0...
  36. ncbi Intracranial pressure levels and single wave amplitudes, Glasgow Coma Score and Glasgow Outcome Score after subarachnoid haemorrhage
    P K Eide
    Department of Neurosurgery, The National Hospital, Rikshospitalet, Oslo, Norway
    Acta Neurochir (Wien) 148:1267-75; discussion 1275-6. 2006
    ..To relate intracranial pressure (ICP) levels and single ICP wave amplitudes to the acute clinical state (Glasgow Coma Score, GCS) and final clinical outcome (Glasgow Outcome Score, GOS) in patients with subarachnoid haemorrhage (SAH)...
  37. ncbi Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome
    K Nylen
    Department of Neurology, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, University of Goteborg, S 413 45 Goteborg, Sweden
    J Neurol Sci 240:85-91. 2006
    ..However, a more specific marker is required and glial fibrillary acidic protein (GFAP) is considered to be a good candidate...
  38. pmc Superior orbital rim approach for anterior communicating artery aneurysms: a surgical series of 27 patients
    Byung Chan Jeon
    Division of Minimally Invasive Neurosurgery, Kosin University Gospel Hospital, Busan, Korea
    J Korean Med Sci 18:566-72. 2003
    ..1%) were from 29 to 79 yr in age. The mean aneurysm size was 6.2 mm ranging from 4 to 12 mm. A favorable Glasgow outcome scale (GOS) of 4 or 5 was achieved in 92.6%, a GOS score of 3 in 3.7%, and 1 death (GOS 1) occurred in 3...
  39. ncbi Intracranial aneurysms in Sarawak General Hospital over a 30-month period
    J S Wong
    Hospital Umum Sarawak, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia
    J Clin Neurosci 11:254-8. 2004
    ..Good results can be achieved in developing countries with early diagnosis and intensive management...
  40. ncbi Outcome of moderate and severe traumatic brain injury amongst the elderly in Singapore
    B K Gan
    Department of Neurosurgery, National Neuroscience Institute, Singapore
    Ann Acad Med Singapore 33:63-7. 2004
    ..In line with other established protocols, our unit has instituted a standardised protocol for the management of moderate and severe traumatic brain injury since 1996 in our neurointensive care unit...
  41. ncbi Endovascular treatment of posterior cerebral artery aneurysms
    W J van Rooij
    Department of Radiology, St Elisabeth Ziekenhuis, Tilburg, Netherlands
    AJNR Am J Neuroradiol 27:300-5. 2006
    ..The purpose of this study was to report the incidence, clinical presentation, endovascular treatment, and outcome of aneurysms of the posterior cerebral artery (PCA)...
  42. ncbi Absolutely no hope? Some ambiguity of futility of care in devastating acute stroke
    Eelco F M Wijdicks
    Neurological Neurosurgical Intensive Care Unit, Saint Marys, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Crit Care Med 32:2332-42. 2004
    ..There has not been a critical review of the data used to make decisions of withdrawal of care in patients with severe strokes...
  43. ncbi Glial fibrillary acidic protein in serum after traumatic brain injury and multiple trauma
    Linda E Pelinka
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and Research Unit of the Austrian Worker s Compensation Board, Vienna, Austria
    J Trauma 57:1006-12. 2004
    ....
  44. ncbi Surgical management of ruptured and unruptured symptomatic posterior inferior cerebellar artery aneurysms
    Donald Liew
    Department of Neurosurgery, National Neuroscience Institute, Singapore
    Br J Neurosurg 18:608-12. 2004
    ..In aneurysms that cannot be clipped, sacrifice of the PICA without revascularisation procedures in proximally located PICA aneurysms may still be feasible if the occlusion is done distal to the perforators...
  45. ncbi Early decompressive craniectomy may be effective in the treatment of refractory intracranial hypertension after traumatic brain injury
    V A Josan
    Department of Paediatric Neurosurgery, Birmingham Children s Hospital, Steelhouse Lane, Birmingham, B4 6NH, UK
    Childs Nerv Syst 22:1268-74. 2006
    ..We compared the effect of early decompressive craniectomy (<24 h) vs non-operative treatment on the outcome of children with refractory intracranial hypertension after severe traumatic brain injury...
  46. ncbi Decompressive laparotomy to treat intractable intracranial hypertension after traumatic brain injury
    D Andrea K Joseph
    Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Trauma 57:687-93; discussion 693-5. 2004
    ..Recently, we noticed that abdominal fascial release could be useful in treating intracranial hypertension (ICH) after traumatic brain injury (TBI). We added this as an option in our treatment of TBI...
  47. ncbi Therapeutic hypothermia in traumatic brain injury
    Joanna E Wright
    Critical Care Services, Scripps Mercy Hospital, San Diego, CA 92103, USA
    Crit Care Nurs Q 28:150-61. 2005
    ..Also included is a review of 2 major randomized, controlled trials of hypothermia for traumatic brain injury that have been instrumental in establishing guidelines and directing further research...
  48. ncbi Traumatic brain injury: a review
    Scot Nolan
    Critical Care Department, Scripps Mercy Hospital, San Diego, CA 92103, USA
    Crit Care Nurs Q 28:188-94. 2005
    ..This article describes the classification, mechanism of injury, pathophysiology, and clinical therapeutic management strategies identified as best practice for TBI...
  49. ncbi [Functional outcome at discharge of patients with severe traumatic brain injury admitted to a brain damage unit]
    F Orient-López
    Unidad de Daño Cerebral, Institut Guttmann, Hospital de Neurorehabilitació, Badalona, Barcelona, Spain
    Rev Neurol 39:901-6. 2004
    ....
  50. ncbi Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy
    I Timofeev
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:11-6. 2006
    ..Outcome was assessed at an interval of at least 6 months following injury using the Glasgow Outcome Scale (GOS) score and the SF-36 quality of life questionnaire...
  51. ncbi Angiography and aneurysms
    Alfonso Lagares
    J Neurosurg 100:982-3; author reply 983-4. 2004
  52. ncbi Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com)
    P J Hutchinson
    Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:17-20. 2006
    ..We describe the concept of decompressive craniectomy in traumatic brain injury and the rationale and protocol of the RESCUEicp study...
  53. ncbi Predictive value of initial computerized tomography scan, intracranial pressure, and state of autoregulation in patients with traumatic brain injury
    Magdalena Hiler
    Academic Neurosurgical Unit, Department of Clinical Neuroscience, University of Cambridge, Addenbrooke s NHS Trust, Cambridge, United Kingdom
    J Neurosurg 104:731-7. 2006
    ....
  54. ncbi Neurologic outcome of posttraumatic refractory intracranial hypertension treated with external lumbar drainage
    Josep M Abadal-Centellas
    Servicio de Medicina Intensiva, Hospital Universitario Son Dureta, Palma de Mallorca, Spain
    J Trauma 62:282-6; discussion 286. 2007
    ..The use of external lumbar drainage (ELD) has been described in these patients. We report our experience with the use of ELD in 17 cases of refractory ICH after severe TBI...
  55. ncbi Alpha-melanocyte-stimulating hormone is decreased in plasma of patients with acute brain injury
    Sandra Magnoni
    Department of Anesthesia and Intensive Care, Ospedale Maggiore di Milano IRCCS, Milano, Italy
    J Neurotrauma 20:251-60. 2003
    ..The data raise the possibility that restoration of normal circulating alpha-MSH through administration of the peptide could be beneficial in patients with brain injury...
  56. ncbi Angiographic follow-up of vertebrobasilar artery aneurysms treated with detachable coils
    C Groden
    Department of Neuroradiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany
    Neuroradiology 45:435-40. 2003
    ..Within the entire second observation period, three (5%) of the 59 patients had a further haemorrhage and were retreated with GDC. Rebleeding proved to be the only factor influencing the clinical outcome of retreated patients...
  57. ncbi Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse
    R A Ruppel
    Department of Anesthesiology, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Pediatr 138:18-25. 2001
    ..Young age and child abuse were associated with extremely high CSF glutamate concentrations after TBI. A possible role for excitotoxicity after pediatric TBI is supported...
  58. ncbi Posttraumatic rehabilitation and one year outcome following acute traumatic brain injury (TBI): data from the well defined population based German Prospective Study 2000-2002
    K R H von Wild
    Medical Faculty, Westphälische Wilhelms University, Munster, Germany
    Acta Neurochir Suppl 101:55-60. 2008
    ..Early outcome after rehabilitation is assessed by the Glasgow Outcome Scale (GOS) score of patients following rehabilitation and of 63% of all TBI with the aid of follow-up ..
  59. ncbi The effect of haematoma, brain injury, and secondary insult on brain swelling in traumatic acute subdural haemorrhage
    S Sawauchi
    Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan
    Acta Neurochir (Wien) 150:531-6; discussion 536. 2008
    ..The purpose of this study was to investigate the pathophysiology of brain swelling associated with ASDH in traumatic brain injury...
  60. ncbi Time course of intracranial hypertension after traumatic brain injury
    Nino Stocchetti
    Anesthesia and Intensive Care Medicine, Milan University, Neuroscience ICU, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, e Regina Elena, Milan, Italy
    J Neurotrauma 24:1339-46. 2007
    ..In these cases, HICP was significantly worse and required more intense therapies...
  61. ncbi Hyponatremia in patients with traumatic brain injury: incidence, mechanism, and response to sodium supplementation or retention therapy with hydrocortisone
    Nobuhiro Moro
    Department of Neurological Surgery, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Surg Neurol 68:387-93. 2007
    ..For sodium retention therapy, hydrocortisone was administered, expecting its mineralocorticoid effect, when the hyponatremia was associated with excess natriuresis...
  62. pmc Impact of age on long-term recovery from traumatic brain injury
    Carlos D Marquez de la Plata
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arch Phys Med Rehabil 89:896-903. 2008
    ..To determine whether older persons are at increased risk for progressive functional decline after traumatic brain injury (TBI)...
  63. ncbi [Craniocerebral gunshot wounds: a study of outcome predictors]
    G Paradot
    Service de neurochirurgie du Kremlin Bicêtre, 78, Avenue du General Leclerc, 94270 Le Kremlin Bicetre, France
    Neurochirurgie 54:79-83. 2008
    ..A retrospective study about craniocerebral gunshot wounds was done to better identify outcome predictors...
  64. ncbi The treatment of refractory intracranial hypertension and its control by means of external lumbar drainage (ELD)
    Hazem Akil
    J Trauma 63:720-1; author reply 721. 2007
  65. ncbi [Idiopathic subarachnoid hemorrhage; comparison of different bleeding patterns and long-term outcome]
    A Lagares
    Servicio de Neurocirugia, Hospital 12 de Octubre, Madrid
    Neurocirugia (Astur) 13:110-9. 2002
    ..This classification could permit the establishment of differences in the management and prognosis...
  66. ncbi Severe traumatic brain injury in children--are the results improving?
    Jurg Pfenninger
    Pediatric Intensive Care Unit, University Children s Hospital, Inselspital, Bern, Switzerland
    Swiss Med Wkly 132:116-20. 2002
    ..Medical management is constantly being refined, and thus results should improve. The aim of the present study was to analyse our data of recent years and to compare them with previous series (1978-83 and 1988-92)...
  67. ncbi Significance of computed tomography mixed density in traumatic extra-axial hemorrhage
    S K Subramanian
    Department of Radiology, Wayne State University School of Medicine, Detroit Receiving Hospital, Detroit, MI, USA
    Neurol Res 24:125-8. 2002
    ..Nevertheless, we conclude clinical exam and other published CT criteria are better indicators of injury severity and outcome...
  68. ncbi Curative effect of wilsonii injecta on severe head injury
    Ligang Chen
    Department of Neurosurgery, General Hospital of Chengdu Military Command, Chengd u 610083, China
    Chin J Traumatol 5:82-5. 2002
    ..To study the curative effect of wilsonii injecta on severe head injury (SHI)...
  69. ncbi Endovascular treatment of ruptured intracranial aneurysms in patients aged 65 years and older: follow-up of 52 patients after 1 year
    J Sedat
    Department of Interventional Neuroradiology, Centre Hospitalier Universitaire Nice, Nice, France
    Stroke 33:2620-5. 2002
    ..We compared endovascular therapy results in patients aged > or =65 and <65 years...
  70. ncbi Continuation of poor surgical outcome after elderly brain injury
    Sandeep Mohindra
    Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Surg Neurol 69:474-7. 2008
    ..In spite of the decline in mortality among trauma patients, with advanced trauma care, the outcome for elderly patients remains poor. Both operative and nonoperative outcome for elderly patients after head trauma has resisted improvement...
  71. ncbi Severe traumatic brain injury in Austria V: CT findings and surgical management
    Johannes Leitgeb
    University Department of Trauma Surgery, General Hospital Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:56-63. 2007
    ..The aim of this paper is to describe CT findings and surgical management of patients with severe traumatic brain injury (TBI) in Austria...
  72. ncbi Severe head injury in early infancy: analysis of causes and possible predictive factors for outcome
    Elisabetta Marton
    Neurosurgery Department, Padova University, Ca Foncello Hospital, 31100 Treviso, Italy
    Childs Nerv Syst 23:873-80. 2007
    ..The aim of this study was to analyse the causes and prognostic factors for outcome in severe traumatic brain injuries (TBI) in early infancy...
  73. ncbi Diffuse alterations in synaptic protein expression following focal traumatic brain injury in the immature rat
    G T Gobbel
    Department of Neurological Surgery, University of Pittsburgh, Suite B 400, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Childs Nerv Syst 23:1171-9. 2007
    ..The present study examined the potential role of synaptic alterations in this process by using an animal model of immature head injury to define the impact of TBI on expression of the synaptic protein, synaptophysin...
  74. ncbi Traumatic acute subdural haematomas of the posterior fossa: clinicoradiological analysis of 24 patients
    D D'Avella
    Clinica Neurochirurgica, Universita di Messina, Messina, Italy
    Acta Neurochir (Wien) 145:1037-44; discussion 1044. 2003
    ..We report 24 patients with a traumatic acute subdural haematoma of the posterior fossa managed between 1997 and 1999 at 8 Italian neurosurgical centres...
  75. ncbi [Subarachnoid hemorrhage without aneurysm]
    W Muller-Forell
    Institut für Neuroradiologie des Universitätsklinikums Mainz, Germany
    Radiologe 42:871-9. 2002
    ....
  76. ncbi Relatives' reports of long term problems following traumatic brain injury or subarachnoid haemorrhage
    D J Hellawell
    Rehabilitation Studies Unit, The University of Edinburgh, UK
    Disabil Rehabil 23:300-5. 2001
    ..The Glasgow Outcome Scale (GOS) and the Relative's Questionnaire (RQ) were used...
  77. ncbi Predictive value of initial clinical status, intracranial pressure and transcranial Doppler pulsatility after subarachnoid haemorrhage
    M Soehle
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Acta Neurochir (Wien) 149:575-83. 2007
    ....
  78. ncbi Intracranial pressure and cerebral perfusion pressure as risk factors in children with traumatic brain injuries
    Albert Català-Temprano
    Pediatric Intensive Care Unit, Pediatrics Department, Integrated Unit Sant Joan de Déu Clínic, Hospital Universitari Sant Joan de Deu, Universitat de Barcelona, Esplugues, Barcelona, Spain
    J Neurosurg 106:463-6. 2007
    ..The authors evaluated the initial intracranial pressure (ICP) and cerebral perfusion pressure (CPP) as prognostic factors in severe head injury in children and tried to determine the optimal CPP range...
  79. ncbi Does intensive rehabilitation improve the functional outcome of patients with traumatic brain injury (TBI)? A randomized controlled trial
    X L Zhu
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, PR China
    Brain Inj 21:681-90. 2007
    ..To evaluate the effects of an increase in the intensity of rehabilitation on the functional outcome of patients with traumatic brain injury (TBI)...
  80. pmc Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans
    Kathleen T Sachse
    Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Cereb Blood Flow Metab 28:395-401. 2008
    ..Demographics, Glasgow Coma Scale (GCS) score, admission blood alcohol level, and 6-month dichotomized Glasgow Outcome Scale (GOS) score were assessed. Mean time from injury to initial CSF sampling was 10.77+/-3.13 h...
  81. ncbi Effects of fentanyl and S(+)-ketamine on cerebral hemodynamics, gastrointestinal motility, and need of vasopressors in patients with intracranial pathologies: a pilot study
    Marc D Schmittner
    Department of Anesthesiology and Critical Care Medicine, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    J Neurosurg Anesthesiol 19:257-62. 2007
    ..Our results indicate that S(+)-ketamine does not increase ICP and that its use in neurosurgical patients should not be discouraged on the basis of ICP-related concerns...
  82. ncbi Multiple interstitial substances measured by microdialysis in patients with subarachnoid hemorrhage
    F Staub
    Department of Neurosurgery, University of Cologne, Germany
    Neurosurgery 47:1106-15; discussion 1115-6. 2000
    ....
  83. pmc Attenuated cerebrospinal fluid leukocyte count and sepsis in adults with pneumococcal meningitis: a prospective cohort study
    Martijn Weisfelt
    Department of Neurology, Centre of Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 6:149. 2006
    ..Whereas a low CSF WBC indicates the presence of sepsis with early meningitis in patients with meningococcal infections, the relation between CSF WBC and outcome in patients with pneumococcal meningitis is not understood...
  84. ncbi Differential responses in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury
    William L Maxwell
    Laboratory of Human Anatomy, Thomson Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Brain 127:2470-8. 2004
    ..the dorsomedial, ventral posterior and lateral posterior thalamic nuclei in patients assessed by the Glasgow Outcome Scale as moderately disabled (n = 9), severely disabled (n = 12) and vegetative (n = 10) head-injured patients ..
  85. ncbi Clinical features and prognostic factors in adults with bacterial meningitis
    Diederik van de Beek
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    N Engl J Med 351:1849-59. 2004
    ..We conducted a nationwide study in the Netherlands to determine clinical features and prognostic factors in adults with community-acquired acute bacterial meningitis...
  86. ncbi Role of decompressive craniectomy in the management of severe head injury with refractory cerebral edema and intractable intracranial pressure. Our experience with 48 cases
    Salvatore Chibbaro
    Department of Neurosurgery, University Hospital, 34100 Trieste, Italy
    Surg Neurol 68:632-8. 2007
    ..Only very few randomized studies relating to this topic exist in the literature, including a very small number of patients with no class I evidence...
  87. ncbi Effects of tissue plasminogen activator for acute ischemic stroke at one year. National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study Group
    T G Kwiatkowski
    Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    N Engl J Med 340:1781-7. 1999
    ..It was unknown, however, whether the benefit would be sustained for longer periods...
  88. ncbi Influence of blood pressure variability on short-term outcome in patients with subarachnoid hemorrhage
    K Beseoglu
    Heinrich Heine Universitat, Neurochirurgische Klinik, Dusseldorf, Germany
    Cent Eur Neurosurg 71:69-74. 2010
    ..The present study was conducted to evaluate the effect of blood pressure, intracranial pressure and cerebral perfusion pressure variation on short-term outcome in patients after severe subarachnoid hemorrhage (SAH)...
  89. ncbi Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: a pilot double-blind randomized trial
    Jay M Meythaler
    Department of Physical Medicine and Rehabilitation, Spain Rehabilitation Center R157, School of Medicine, University of Alabama at Birmingham, 619 6th Avenue, Birmingham, AL 35249 7330, USA
    J Head Trauma Rehabil 17:300-13. 2002
    ..Because of its affect on both dopamine and N-methyl-D-aspartate (NMDA) channels, amantadine has been the subject of considerable interest and clinical use in acute TBI...
  90. ncbi The role of hypothermia in the management of severe brain injury: a meta-analysis
    Odette A Harris
    Department of Neurosurgery, Stanford University Medical Center, 300 Pasteur Dr, Edwards Bldg, Second Floor, Stanford, CA 94305, USA
    Arch Neurol 59:1077-83. 2002
    ..Hypothermia is utilized in the management of severe traumatic brain injury despite the lack of unequivocal evidence supporting its use. Because of its widespread use, the effects of hypothermia are a concern...
  91. ncbi Incidence and prognostic significance of fever following intracerebral hemorrhage
    S Schwarz
    Department of Neurology, University of Heidelberg, Germany
    Neurology 54:354-61. 2000
    ..To investigate the incidence and prognostic significance of fever on presentation and during the subsequent 72 hours in patients with spontaneous supratentorial intracerebral hemorrhage (ICH)...
  92. ncbi Effects of intraoperative hypothermia on neuropsychological outcomes after intracranial aneurysm surgery
    Steven W Anderson
    Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Ann Neurol 60:518-27. 2006
    ..improve neurological outcome in good-grade surgical subarachnoid hemorrhage patients, as assessed by the Glasgow Outcome Scale score or other neurological and functional measures (National Institutes of Health Stroke Scale, Rankin ..
  93. ncbi Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: a prospective randomized study
    Jan Hillman
    Neurosurgical Department, University Hospital Linkoping, University Hospital Lund, Sweden
    J Neurosurg 97:771-8. 2002
    ..The object of this randomized, prospective, multicenter study was to assess the efficacy of short-term antifibrinolytic treatment with tranexamic acid in preventing rebleeding...
  94. ncbi Post-operative hematoma after surgery for intracranial meningiomas: causes, avoidable risk factors and clinical outcome
    Rüdiger Gerlach
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurol Res 26:61-6. 2004
    ..Outcome of patients with post-operative hematoma was assessed according to the Glasgow Outcome Scale (GOS) at discharge and at three months. 21 patients (7...
  95. ncbi Implications of excessive fibrinolysis and alpha(2)-plasmin inhibitor deficiency in patients with severe head injury
    S Kushimoto
    Department of Emergency and Critical Care Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    Neurosurgery 49:1084-9; discussion 1089-90. 2001
    ..To evaluate the involvement of the fibrinolytic system, especially focused on alpha(2)-plasmin inhibitor, in patients with head injury...
  96. pmc Fibered electrolytically detachable platinum coils used for the endovascular treatment of intracranial aneurysms. Initial experiences and mid-term results in 474 aneurysms
    T Liebig
    Klinik für Radiologie und Neuroradiologie, Alfried Krupp von Bohlen und Halbach Krankenhaus, Essen Germany
    Interv Neuroradiol 10:5-26. 2004
    ..use and percentage of fibered coils, occlusion rate, procedural complications, early clinical outcome and Glasgow Outcome Scale (GOS) scores...
  97. ncbi Diagnostic MR imaging features of craniocerebral Aspergillosis of sino-nasal origin in immunocompetent patients
    A A Siddiqui
    Division of Neurosurgery, The Aga Khan University Hospital, Karachi, Pakistan
    Acta Neurochir (Wien) 148:155-66; discussion 166. 2006
    ..This retrospective study focuses on characteristic MR imaging features of Aspergillosis (of sinonasal origin) in immunocompetent patients...
  98. ncbi Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases
    Stefan Kastenbauer
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Brain 126:1015-25. 2003
    ..The in-hospital mortality was 24.1%. Only 48.3% of the patients had a good outcome at discharge [Glasgow Outcome Scale Score (GOS) = 5]...
  99. ncbi Neuropsychological sequelae of bacterial and viral meningitis
    H Schmidt
    Georg August University Gottingen, Department of Neurology, Gottingen, Germany
    Brain 129:333-45. 2006
    ..Patients with a Glasgow Outcome Scale (GOS) of <5 had more frequently impaired test results for non-verbal learning and memory...
  100. ncbi The prognostic value of NSE and S100B from serum and cerebrospinal fluid in patients with spontaneous subarachnoid hemorrhage
    Stefan Moritz
    Department of Anesthesiology, University of Regensburg, Medical Center, RegensburgGermany
    J Neurosurg Anesthesiol 22:21-31. 2010
    ..At ICU discharge patients' outcome was assessed by the Glasgow outcome scale and occurrence of cerebral infarction, vasospasm and intracranial hypertension were registered...
  101. pmc Outcome in patients with blunt head trauma and a Glasgow Coma Scale score of 3 at presentation
    Roukoz B Chamoun
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosurg 111:683-7. 2009
    ..In this paper, the authors' purpose is to report their experience in the management of this patient population, analyzing the mortality rate, prognostic factors, and functional outcome of survivors...

Research Grants41

  1. Treatment of Subarachnoid Hemorrhage with Human Albumin
    Jose I Suarez; Fiscal Year: 2010
    ..The three-month functional outcome determined',by Glasgow Outcome Scale, Barthel Index, modified Rankin Scale, NIH Stroke Scale and Stroke Impact Scale will be;measured to obtain ..
  2. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..is to examine the association between body temperature and neurologic outcome as measured by Extended Glasgow Outcome Scale (GOS-E) in patients ages 16 years and older after blunt moderate or severe TBI...
  3. Phase II, randomized controlled trial of brain tissue oxygen monitoring
    Nancy R Temkin; Fiscal Year: 2011
    ..4). Non-futility hypothesis. A relative risk of good outcome measured by the Glasgow Outcome Scale-Extended 6-months after injury of 2.0 is consistent with the results of this phase II study...
  4. HYPOTHERMIA DURING INTRACRANIAL ANEURYSM SURGERY
    Michael Todd; Fiscal Year: 2003
    ..limited to the intraoperative period, will result in an improvement in neurologic outcome as measured by Glasgow Outcome Scale at 3months following surgery, and will also result in more rapid improvement during the first ..
  5. EARLY HEMICRANIECTOMY TO MANAGE TRAUMATIC BRAIN INJURY
    William Coplin; Fiscal Year: 1999
    ..The primary outcome measure is the six-month Glasgow Outcome Scale. Secondary outcome measures include the Disability Rating Scale, Functional Independence Measures, and the ..
  6. An Acute Neurobehavioral Program for Improving Functional Status after TBI
    Janet P Niemeier; Fiscal Year: 2012
    ..will secondarily compare scores on the Disability Rating Scale (DRS), Neurobehavioral Rating Scale (NRS), Glasgow Outcome Scale-Extended (GOSE), Rehabilitation Intensity of Therapy Scale (RITS), and the Frontal Systems Behavior Scale (..
  7. ANGIOPLASTY IN ANEURYSMAL SUBARACHNOID HEMORRHAGE
    J Muizelaar; Fiscal Year: 2005
    ..Primary outcome will be the dichotomized Glasgow Outcome Scale (GOS) at three months...
  8. DATA MANAGEMENT CENTER--TRIAL OF ORG 10172 IN STROKE
    Robert Woolson; Fiscal Year: 2000
    ..stroke, ORG 10172 is more efficacious than placebo in improving the likelihood of a favorable outcome (Glasgow Outcome Scale of I or II and Barthel Index of 12 or more) at three months after stroke...
  9. THE EFFECT OF APOE ON OUTCOMES IN TBI ADULTS
    Yvette Conley; Fiscal Year: 2003
    ..a difference in the functional outcomes (mortality, and neuropsychologic evaluation measured using the Glasgow Outcome Scale, Disability Rating Scale and the Neurobehavioral rating scale) at 3 and 6 months after TBI between ..
  10. HYPERTONIC SALINE FOR INCREASED ICP FOLLOWING HEAD INJU*
    Lawrence Marshall; Fiscal Year: 2002
    ..the 6-month Glasgow Outcome Scale, the COAT (Children's Orientation Amnesia Test), and the Divided Attention Test.
  11. Quality of Life in Patients with Brain Metastases
    Joseph King; Fiscal Year: 2005
    ..abstract_text> ..
  12. Clinical trial design and analysis in traumatic brain injury
    Andrew Maas; Fiscal Year: 2009
    ..IMPACT: International Mission on Prognosis and Analysis of Clinical Trials in TBI. ..
  13. CPP Management Information Feedback and Nursing
    Catherine Kirkness; Fiscal Year: 2007
    ..abstract_text> ..
  14. Gender Differences in Dopamine Function after TBI
    Amy Wagner; Fiscal Year: 2003
    ....
  15. Dopamine Genetic Variants Modulating Recovery After TBI
    Amy Wagner; Fiscal Year: 2008
    ..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. [unreadable] [unreadable] [unreadable]..
  16. Dopamine Function in TBI--Therapeutic Intervention
    Amy Wagner; Fiscal Year: 2005
    ..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
  17. Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBI
    Amy Wagner; Fiscal Year: 2008
    ..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
  18. Hemodynamics and Outcome in Pediatric Brain Injury
    MONICA VAVILALA; Fiscal Year: 2007
    ..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
  19. Cerebral Edema in Pediatric Diabetic Ketoacidosis
    MONICA VAVILALA; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  20. Glucose Regulation in Acute Stroke Patients (GRASP)
    Karen Johnston; Fiscal Year: 2007
    ....
  21. PREDICTIVE RISK MODEL IN ACUTE ISCHEMIC STROKE
    Karen Johnston; Fiscal Year: 2004
    ..This will be valuable to patients with stroke, providers, payers and developers of new drug therapies. ..
  22. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  23. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  24. RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODEL
    Michael Lawton; Fiscal Year: 2004
    ..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs. ..
  25. Genetic factors in outcome from traumatic brain injury
    Ramon Diaz Arrastia; Fiscal Year: 2008
    ..These studies may provide genetic evidence for a role of specific genes in tissue response after TBI, and may identify novel targets for therapeutic intervention. ..
  26. Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein E
    Sheila Alexander; Fiscal Year: 2009
    ..This would likely lead to decreased time in the ICU and hospital. ..
  27. EARLY DETERMINATION OF STROKE SUBTYPE: CT ANGIOGRAPHY
    Scott Kasner; Fiscal Year: 2003
    ..This approach will, for the first time, formally evaluate CTA as a tool for early stroke diagnosis and selection of patients with specific stroke mechanisms for specific mechanism-directed stroke therapies. ..
  28. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
    ..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..
  29. Improving Activity and Participation After Limb Loss: PALS-Plus
    Stephen Wegener; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
  31. Efficacy of Hypothermia in Pediatric TBI
    P David Adelson; Fiscal Year: 2004
    ..Parallel clinical specific aims will define the effect of neurotransmitter release in response to treatment with HYPO and the age-related impact of HYPO on early and delayed cell death in children. ..
  32. Neurorehabilitation with Progesterone & Pregnenolone
    David Wright; Fiscal Year: 2005
    ..Therefore, we will examine two delayed treatment paradigms (7 days & 28 days post injury) on the recovery process at the behavioral and morphological levels of analysis. ..
  33. ProTECT II: Progesterone for TBI, MCCT Planning Grant
    David Wright; Fiscal Year: 2007
    ..The primary functional outcome will be determined by Glasgow Outcome Scale - Enhanced (GOSE) measured at 6 months after injury...
  34. Using Biochemical Markers to Detect Abusive Head Trauma
    Rachel Berger; Fiscal Year: 2007
    ..abstract_text> ..
  35. PATHOPHYSIOLOGY OF CHRONIC CEREBRAL VASOSPASM
    Robert MacDonald; Fiscal Year: 2005
    ..abstract_text> ..
  36. TRAUMA-RELATED ERYTHROPOIETIC SUPPRESSION
    David Livingston; Fiscal Year: 2003
    ..Understanding the mechanisms behind post-trauma anemia will allow therapeutic interventions improving endogenous erythropoiesis to be targeted. ..
  37. Post Traumatic Brain Injury (TBI) Depression
    Vani Rao; Fiscal Year: 2008
    ..All three hypotheses will hold true at each time point, even when gender, personal past psychiatric history, family history, and alcohol/substance abuse/depedence are adjusted for in the analysis. [unreadable] [unreadable]..
  38. Modeling and Assessment of Cerebrovascular Autoregulation
    Michael Daley; Fiscal Year: 2006
    ..Simulation of ICP with a third order windkessel model of intracranial pressure dynamics will be used to examine the biomechanical mechanisms underlying active and passive regulation of cerebral blood flow. [unreadable] [unreadable]..