glasgow coma scale

Summary

Summary: A scale that assesses the response to stimuli in patients with craniocerebral injuries. The parameters are eye opening, motor response, and verbal response.

Top Publications

  1. ncbi Poisoning severity score, Glasgow coma scale, corrected QT interval in acute organophosphate poisoning
    Okhan Akdur
    Canakkale Onsekiz Mart University Faculty of Medicine, Department of Emergency Medicine, Canakkale, Turkey
    Hum Exp Toxicol 29:419-25. 2010
  2. ncbi Indications for computed tomography in patients with minor head injury
    M J Haydel
    Section of Emergency Medicine, Louisiana State University Health Science Center at New Orleans, USA
    N Engl J Med 343:100-5. 2000
  3. pmc Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients
    Pablo Perel
    London School of Hygiene and Tropical Medicine, London WC1B 3DP
    BMJ 336:425-9. 2008
  4. pmc Classification of traumatic brain injury for targeted therapies
    Kathryn E Saatman
    University of Kentucky, Lexington, KY, USA
    J Neurotrauma 25:719-38. 2008
  5. ncbi ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury
    David W Wright
    Department of Emergency Medicine, School of Medicine of Emory University, Atlanta, GA, USA
    Ann Emerg Med 49:391-402, 402.e1-2. 2007
  6. ncbi The ICH score: a simple, reliable grading scale for intracerebral hemorrhage
    J C Hemphill
    Department of Neurology, University of California, San Francisco, USA
    Stroke 32:891-7. 2001
  7. ncbi The Canadian CT Head Rule for patients with minor head injury
    I G Stiell
    Divisions of Emergency Medicine, University of British Columbia, Vancouver, Canada
    Lancet 357:1391-6. 2001
  8. pmc Revised trauma scoring system to predict in-hospital mortality in the emergency department: Glasgow Coma Scale, Age, and Systolic Blood Pressure score
    Yutaka Kondo
    Department of Emergency Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Crit Care 15:R191. 2011
  9. ncbi S100-B protein as a screening tool for the early assessment of minor head injury
    Drissa Zongo
    Service des urgences adultes, Hopital Pellegrin, Bordeaux, France
    Ann Emerg Med 59:209-18. 2012
  10. ncbi Reliability of the Glasgow Coma Scale for the emergency department evaluation of poisoned patients
    Kennon Heard
    The University of Colorado Health Sciences Center, Division of Emergency Medicine, Denver, CO 80262, USA
    Hum Exp Toxicol 23:197-200. 2004

Detail Information

Publications268 found, 100 shown here

  1. ncbi Poisoning severity score, Glasgow coma scale, corrected QT interval in acute organophosphate poisoning
    Okhan Akdur
    Canakkale Onsekiz Mart University Faculty of Medicine, Department of Emergency Medicine, Canakkale, Turkey
    Hum Exp Toxicol 29:419-25. 2010
    The aim of this study was to investigate effectiveness of the poisoning severity score (PSS), Glasgow coma scale (GCS), and corrected QT (QTc) interval in predicting outcomes in acute organophosphates (OP) poisoning...
  2. ncbi Indications for computed tomography in patients with minor head injury
    M J Haydel
    Section of Emergency Medicine, Louisiana State University Health Science Center at New Orleans, USA
    N Engl J Med 343:100-5. 2000
    ..We performed a study to develop and validate a set of clinical criteria that could be used to identify patients with minor head injury who do not need to undergo CT...
  3. pmc Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients
    Pablo Perel
    London School of Hygiene and Tropical Medicine, London WC1B 3DP
    BMJ 336:425-9. 2008
    ..To develop and validate practical prognostic models for death at 14 days and for death or severe disability six months after traumatic brain injury...
  4. pmc Classification of traumatic brain injury for targeted therapies
    Kathryn E Saatman
    University of Kentucky, Lexington, KY, USA
    J Neurotrauma 25:719-38. 2008
    ..Currently, the Glasgow Coma Scale (GCS) is the primary selection criterion for inclusion in most TBI clinical trials...
  5. ncbi ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury
    David W Wright
    Department of Emergency Medicine, School of Medicine of Emory University, Atlanta, GA, USA
    Ann Emerg Med 49:391-402, 402.e1-2. 2007
    ..Laboratory evidence indicates that progesterone has potent neuroprotective effects. We conducted a pilot clinical trial to assess the safety and potential benefit of administering progesterone to patients with acute traumatic brain injury...
  6. ncbi The ICH score: a simple, reliable grading scale for intracerebral hemorrhage
    J C Hemphill
    Department of Neurology, University of California, San Francisco, USA
    Stroke 32:891-7. 2001
    ..Despite several existing outcome prediction models for ICH, there is no standard clinical grading scale for ICH analogous to those for traumatic brain injury, subarachnoid hemorrhage, or ischemic stroke...
  7. ncbi The Canadian CT Head Rule for patients with minor head injury
    I G Stiell
    Divisions of Emergency Medicine, University of British Columbia, Vancouver, Canada
    Lancet 357:1391-6. 2001
    ..There is much controversy about the use of computed tomography (CT) for patients with minor head injury. We aimed to develop a highly sensitive clinical decision rule for use of CT in patients with minor head injuries...
  8. pmc Revised trauma scoring system to predict in-hospital mortality in the emergency department: Glasgow Coma Scale, Age, and Systolic Blood Pressure score
    Yutaka Kondo
    Department of Emergency Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Crit Care 15:R191. 2011
    Our aim in this study was to assess whether the new Glasgow Coma Scale, Age, and Systolic Blood Pressure (GAP) scoring system, which is a modification of the Mechanism, Glasgow Coma Scale, Age, and Arterial Pressure (MGAP) scoring system, ..
  9. ncbi S100-B protein as a screening tool for the early assessment of minor head injury
    Drissa Zongo
    Service des urgences adultes, Hopital Pellegrin, Bordeaux, France
    Ann Emerg Med 59:209-18. 2012
    ..We evaluate S100-B protein measurement as a screening tool in a large population of patients with minor head injury...
  10. ncbi Reliability of the Glasgow Coma Scale for the emergency department evaluation of poisoned patients
    Kennon Heard
    The University of Colorado Health Sciences Center, Division of Emergency Medicine, Denver, CO 80262, USA
    Hum Exp Toxicol 23:197-200. 2004
    The Glasgow Coma Scale (GCS) was developed for monitoring the mental status of head-injured patients in the intensive care unit...
  11. pmc Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury
    Stefania Mondello
    Department of Anesthesiology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA
    Neurosurgery 70:666-75. 2012
    ..Brain damage markers released in cerebrospinal fluid (CSF) and blood may provide valuable information about diagnosis and outcome prediction after traumatic brain injury (TBI)...
  12. ncbi Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients
    Chantal W P M Hukkelhoven
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 99:666-73. 2003
    ..The authors studied the shape and strength of the relationship between age and outcome, that is, the 6-month mortality rate and unfavorable outcome based on the Glasgow Outcome Scale...
  13. pmc Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial
    Guomin Xiao
    Department of Neurosurgery and Neurotrauma Center, Affiliated Hospital, College of Medicine, Hangzhou Normal University, Hangzhou 310015, China
    Crit Care 12:R61. 2008
    ..The aim of the present clinical study was to assess the longer-term efficacy of progesterone on the improvement in neurologic outcome of patients with acute severe TBI...
  14. ncbi Injury-associated hypothermia: an analysis of the 2004 National Trauma Data Bank
    R Shayn Martin
    Department of Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Shock 24:114-8. 2005
    ..Although shock severity is highly indicative of outcome, hypothermia independently contributes to the substantial mortality associated with severe injury...
  15. pmc Impact of early intervention on outcome following mild head injury in adults
    J Ponsford
    Monash Epworth Rehabilitation Research Centre, Epworth Hospital, Richmond, Victoria, Australia
    J Neurol Neurosurg Psychiatry 73:330-2. 2002
    ..The impact of mild head injury is variable and determinants of outcome remain poorly understood. Results of previous intervention studies have been mixed...
  16. pmc CATCH: a clinical decision rule for the use of computed tomography in children with minor head injury
    Martin H Osmond
    Department of Pediatrics, University of Ottawa and the Clinical Research Unit, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario
    CMAJ 182:341-8. 2010
    ..There is controversy about which children with minor head injury need to undergo computed tomography (CT). We aimed to develop a highly sensitive clinical decision rule for the use of CT in children with minor head injury...
  17. ncbi Increased matrix metalloproteinase-9 in blood in association with activation of interleukin-6 after traumatic brain injury: influence of hypothermic therapy
    Eiichi Suehiro
    Department of Neurosurgery, Clinical Neuroscience, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    J Neurotrauma 21:1706-11. 2004
    ..The elevation of MMP-9 is associated with inflammatory events following TBI. Hypothermic intervention may suppress the elevation of MMP-9 with suppression of the inflammatory response, affording neuroprotection in TBI...
  18. ncbi Neuron-specific enolase, S100B, and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury
    Ana Elisa Böhmer
    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto, Alegre, RS, Brazil
    Neurosurgery 68:1624-30; discussion 1630-1. 2011
    ..The availability of markers able to provide an early insight related to prognostic and functional outcome of patients with traumatic brain injury (TBI) are limited...
  19. ncbi Risk factors for posttraumatic cerebral infarction in patients with moderate or severe head trauma
    Heng Li Tian
    Department of Neurosurgery, Shanghai Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Neurosurg Rev 31:431-6; discussion 436-7. 2008
    ..Low GCS, low systolic BP, brain herniation, and decompression craniotomy may be risk factors for PTCI in patients with moderate or severe traumatic brain injury...
  20. pmc Resting cerebral blood flow alterations in chronic traumatic brain injury: an arterial spin labeling perfusion FMRI study
    Junghoon Kim
    Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, Elkins Park, Pennsylvania 19027, USA
    J Neurotrauma 27:1399-411. 2010
    ..We also speculate that resting reductions in posterior cingulate perfusion may reflect alterations in the default-mode network, and may contribute to the attentional deficits common in TBI...
  21. ncbi Prognostic value of time-related Glasgow coma scale components in severe traumatic brain injury: a prospective evaluation with respect to 1-year survival and functional outcome
    Efthimios J Kouloulas
    Department of Neurosurgery, Attikon University Hospital, University of Athens Medical School, Greece
    Int J Rehabil Res 36:260-7. 2013
    ..To evaluate whether the three components of the Glasgow Coma Scale (GCS) and their alterations over time can serve as predictors of functional outcome after a severe TBI at 12 ..
  22. ncbi The influence of hemocoagulative disorders on the outcome of children with head injury
    A Chiaretti
    Pediatric Intensive Care Unit, Catholic University Medical School, I 00168 Rome, Italy
    Pediatr Neurosurg 34:131-7. 2001
    ..Although disseminated intravascular coagulation (DIC) and other hemocoagulative abnormalities are severe complications of head injury, their effect on clinical outcome remains unclear, particularly among children...
  23. ncbi Relationship among subjective sleep complaints, headaches, and mood alterations following a mild traumatic brain injury
    Geneviève Chaput
    Facultés de Médecine Dentaire et de Médecine, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, Que, Canada
    Sleep Med 10:713-6. 2009
    ..The objective of this retrospective study was to assess the relationships between the above symptoms. Our hypothesis was that sleep complaints might be among the risk factors for the development of headaches and mood alterations...
  24. ncbi Coagulation abnormalities associated with severe isolated traumatic brain injury: cerebral arterio-venous differences in coagulation and inflammatory markers
    Michael Nekludov
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital and Institutet, 17176 Stockholm, Sweden
    J Neurotrauma 24:174-80. 2007
    ..IL-6 and activation of the complement system (C5b-9) co-vary with hemostatic parameters in TBI patients...
  25. ncbi Subjective and objective measures of insomnia in the context of traumatic brain injury: a preliminary study
    Marie Christine Ouellet
    Ecole de Psychologie, Universite Laval, Pavillon Félix Antoine Savard, Que, Canada G1K 7P4
    Sleep Med 7:486-97. 2006
    ..To compare subjective and objective measures of sleep in traumatic brain injury patients (TBI) suffering from insomnia and in controls...
  26. ncbi S100B serum level predicts computed tomography findings after minor head injury
    Kay Müller
    Department of Neurosurgery, University Hospital of North Norway, Tromsø, Norway
    J Trauma 62:1452-6. 2007
    ..The present multicenter study was performed to investigate whether determination of protein S100B in serum could contribute to the selection of patients for CT scanning...
  27. ncbi Long-term behavior problems following pediatric traumatic brain injury: prevalence, predictors, and correlates
    Lisa Schwartz
    Case Western Reserve University, Department of Psychology, Cleveland, Ohio 44106 7123, USA
    J Pediatr Psychol 28:251-63. 2003
    ..To study identified rates of long-term behavior problems in children with traumatic brain injury (TBI) compared to children with only orthopedic injuries and risk factors and correlates for new behavior problems following TBI...
  28. ncbi Outcome and prognostic factors in head injuries with an admission Glasgow Coma Scale score of 3
    Demetrios Demetriades
    Division of Trauma, Surgical Intensive Care Unit, Los Angeles County, and University of Southern California Medical Center, Los Angeles, CA 90033, USA
    Arch Surg 139:1066-8. 2004
    To identify significant risk factors associated with mortality in patients with a Glasgow Coma Scale score of 3.
  29. ncbi The use of Glasgow Coma Scale in injury assessment: a critical review
    Mathias Zuercher
    Department of Anaesthesia and Intensive Care, University Hospital Basel, Basel, Switzerland
    Brain Inj 23:371-84. 2009
    Patients with brain injuries are assessed using the Glasgow Coma Scale (GCS). This review evaluates the use of GCS scoring in medical literature and identifies the reasons for inaccuracy...
  30. ncbi Validation of a new coma scale: The FOUR score
    Eelco F M Wijdicks
    Division of Critical Care Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 58:585-93. 2005
    The Glasgow Coma Scale (GCS) has been widely adopted. Failure to assess the verbal score in intubated patients and the inability to test brainstem reflexes are shortcomings...
  31. ncbi Prognosis of traumatic head injury in South Tunisia: a multivariate analysis of 437 cases
    Mabrouk Bahloul
    Department of Intensive Care, Habib Bourguiba University Hospital, Sfax, Tunisia
    J Trauma 57:255-61. 2004
    ..This study aimed to determine predictive factors of mortality after posttraumatic brain injury...
  32. ncbi Glasgow Coma Scale in acute poisonings before and after use of antidote in patients with history of use of psychotropic agents
    Tonka Poplas-Susić
    Department of Family Medicine, Ljubljana, Slovenia
    Srp Arh Celok Lek 138:210-3. 2010
    ..Data on emergency interventions in poisonings are scarce. Objective To determine the effectiveness of antidote therapy in acute poisoning-related emergency medical services (EMS) interventions...
  33. ncbi Subacute stereotactic aspiration of haematomas within the basal ganglia reduces occurrence of complications in the course of haemorrhagic stroke in non-comatose patients
    Gerhard Marquardt
    Neurosurgical Clinic, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Cerebrovasc Dis 15:252-7. 2003
    ..The aim of this study was to examine whether subacute stereotactic aspiration of haematomas within the basal ganglia is suitable to reduce the occurrence of complications in the course of haemorrhagic stroke in non-comatose patients...
  34. ncbi Comparison of consciousness level assessment in the poisoned patient using the alert/verbal/painful/unresponsive scale and the Glasgow Coma Scale
    Catherine Anne Kelly
    Scottish Poisons Information Bureau, Royal Infirmary, Edinburgh, Scotland, United Kingdom
    Ann Emerg Med 44:108-13. 2004
    ..AVPU) responsiveness scale (alert, responsive to verbal stimulation, responsive to painful stimulation, and unresponsive) corresponds to the Glasgow Coma Scale (GCS) when assessing consciousness level in the poisoned patient.
  35. ncbi Do trauma patients with a Glasgow Coma Scale score of 3 and bilateral fixed and dilated pupils have any chance of survival?
    Homer C Tien
    Trauma Program and the Department of Surgery, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    J Trauma 60:274-8. 2006
    Low Glasgow Coma Scale score (GCS) and pupillary status predict poor outcomes in head injury (HI) patients...
  36. pmc Outcome in patients with blunt head trauma and a Glasgow Coma Scale score of 3 at presentation
    Roukoz B Chamoun
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosurg 111:683-7. 2009
    A Glasgow Coma Scale (GCS) score of 3 on presentation in patients with severe traumatic brain injury due to blunt trauma has been recognized as a bad prognostic factor...
  37. pmc Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage
    Christian Zweifel
    Department of Neurosurgery, University Hospital of Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    BMC Neurol 10:34. 2010
    ..Copeptin, the C-terminal part of provasopressin, has emerged as a new prognostic marker in a variety of diseases, but its prognostic value in ICH is unknown...
  38. ncbi Patient outcome after traumatic brain injury in high-, middle- and low-income countries: analysis of data on 8927 patients in 46 countries
    Mary J De Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
    Int J Epidemiol 38:452-8. 2009
    ..Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. The burden of TBI is greatest in low- and middle-income countries (LAMIC), yet little is known about patient outcomes in these settings...
  39. ncbi Interrater reliability of Glasgow Coma Scale scores in the emergency department
    Michelle R Gill
    Department of Emergency Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA
    Ann Emerg Med 43:215-23. 2004
    Emergency physicians often use the Glasgow Coma Scale (GCS) to help guide decisions in patient care, yet the reliability of the GCS has never been tested in a typical broad sample of emergency department (ED) patients...
  40. ncbi Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination
    Matthew M Carrick
    Michel E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    J Trauma 58:725-9; discussion 729-30. 2005
    ..This study assessed the development of thrombocytopenia and coagulopathy at admission and within the subsequent 72 hours after TBI...
  41. ncbi Use of the original, modified, or new intracerebral hemorrhage score to predict mortality and morbidity after intracerebral hemorrhage
    Raymond Tak Fai Cheung
    Division of Neurology, University Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    Stroke 34:1717-22. 2003
    A simple clinical scale of intracerebral hemorrhage (ICH), comprising the Glasgow Coma Scale score, age, infratentorial origin, ICH volume, and intraventricular hemorrhage, was recently shown to predict 30-day mortality...
  42. ncbi Bispectral Index monitoring correlates with sedation scales in brain-injured patients
    Anupa Deogaonkar
    Department of Anesthesiology, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Crit Care Med 32:2403-6. 2004
    ..population the correlation between the Bispectral Index (BIS) and three commonly used sedation agitation scales: the Richmond Agitation-Sedation Scale (RASS), the Sedation-Agitation Scale (SAS) and the Glasgow Coma Scale (GCS) scores.
  43. ncbi Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial
    A David Mendelow
    Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Lancet 365:387-97. 2005
    ..We undertook a prospective randomised trial to compare early surgery with initial conservative treatment for patients with intracerebral haemorrhage...
  44. pmc Effect of noninvasive mechanical ventilation in elderly patients with hypercapnic acute-on-chronic respiratory failure and a do-not-intubate order
    Paolo Scarpazza
    Divisione di Broncopneumotisiologia, Ospedale Civile, Vimercate, Italy
    Int J Chron Obstruct Pulmon Dis 3:797-801. 2008
    ..We conclude that elderly patients with acute hypercapnic ARF with a DNI status can be successfully treated by NIMV...
  45. ncbi Coagulopathy as a parameter to predict the outcome in head injury patients--analysis of 61 cases
    Jinn Rung Kuo
    Department of Neurosurgery, Chi Mei Medical Center, Yung Kang City, Tainan, Taiwan
    J Clin Neurosci 11:710-4. 2004
    ..We conclude that: (1) Coagulation state in head injury patients within 24 h after injury is of value in determining the outcome. (2) Coagulopathy score > or = 4 is a good predictor to evaluate mortality rate of head injury patients...
  46. ncbi Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral hemorrhage
    James M Gebel
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Stroke 33:2636-41. 2002
    ..We hypothesized that increasing baseline relative edema volume is associated with greater probability of poor functional outcome...
  47. ncbi Profile of chest trauma in a level I trauma center
    Pankaj Kulshrestha
    Department of Surgery, Baystate Medical Center, Springfield, Massachusetts, USA
    J Trauma 57:576-81. 2004
    ..Chest injuries are seen with increasing frequency in urban hospitals. The profile of chest injuries depends on the size of the hospital and the level of trauma center. The data regarding the true incidence of chest trauma are scant...
  48. ncbi Beta-blockers in isolated blunt head injury
    Kenji Inaba
    Division of Trauma Surgery and Surgical Critical Care, Department of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Am Coll Surg 206:432-8. 2008
    ..The purpose of this study was to evaluate the effect of beta-blockers on patients sustaining acute traumatic brain injury. Our hypothesis was that beta-blocker exposure is associated with improved survival...
  49. ncbi Prediction of 'awakening' and outcome in prolonged acute coma from severe traumatic brain injury: evidence for validity of short latency SEPs
    Aldo Amantini
    Department of Neurological and Psychiatric Sciences, University of Florence, Az Ospedaliera Careggi, V le Morgagni 85, Firenze 50134, Italy
    Clin Neurophysiol 116:229-35. 2005
    ..To evaluate the prognostic value of somatosensory evoked potentials (SEPs) in severe traumatic brain injury (TBI) considering both 'awakening' and disability...
  50. pmc Effect of alcohol on Glasgow Coma Scale in head-injured patients
    Lance Stuke
    Department of Surgery, Division of Burns, Trauma and Surgical Critical Care, University of Texas Southwestern Medical School, Dallas, TX 75390 9158, USA
    Ann Surg 245:651-5. 2007
    Almost 50% of traumatic brain-injured (TBI) patients are alcohol intoxicated. The Glasgow Coma Scale (GCS) is frequently used to direct diagnostic and therapeutic decisions in these patients...
  51. ncbi Prognosis in moderate and severe traumatic brain injury: external validation of the IMPACT models and the role of extracranial injuries
    Hester Lingsma
    Departments of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Trauma Acute Care Surg 74:639-46. 2013
    ..We aimed to validate the International Mission on Prognosis and Analysis of Clinical Trials in TBI (IMPACT) prognostic models in a recent unselected patient cohort and to assess the additional prognostic value of extracranial injury...
  52. pmc Surgical trial in lobar intracerebral haemorrhage (STICH II) protocol
    A David Mendelow
    STICH Office, Neurosurgical Trials Unit, Newcastle University, 3 4 Claremont Terrace, Newcastle upon Tyne, NE2 4AE, UK
    Trials 12:124. 2011
    ..The STICH II study will establish whether a policy of earlier surgical evacuation of the haematoma in selected patients will improve outcome compared to a policy of initial conservative treatment...
  53. ncbi Long-term sleep disturbances in adolescents after minor head injury
    Y Kaufman
    Sleep Laboratory; Rambam Medical Center and Technion--IIT, Haifa, Israel
    Pediatr Neurol 24:129-34. 2001
    ..2 +/- [0.8]; P = 0.063). Our data demonstrated that 3 years after MHI without any discernible clinical sequel, adolescents still complain of sleep disturbances that could be confirmed by both polysomnographic and actigraphic monitoring...
  54. ncbi Raised parenchymal interleukin-6 levels correlate with improved outcome after traumatic brain injury
    Craig D Winter
    Neurosurgical Department, Wessex Neurological Centre, Southampton, University Hospitals NHS Trust, School of Medicine, University of Southampton, SO16 7PX, UK
    Brain 127:315-20. 2004
    ..34, P = 0.03, n = 14). The levels of IL-1beta and NGF were similar in both groups of patients. From these data, we suggest that IL-6 is an endogenous neuroprotective cytokine produced in response to severe head trauma...
  55. ncbi The motor response to stimulation predicts outcome as well as the full Glasgow Coma Scale in children with severe head injury
    Peter Marc Fortune
    Paediatric Care, Royal Manchester Children s Hospital, Manchester, UK
    Pediatr Crit Care Med 11:339-42. 2010
    To evaluate how well the full Glasgow Coma Scale and the motor response, which is a subscore of the Glasgow Coma Scale, predict the outcome in children who have sustained a traumatic brain injury...
  56. ncbi Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension
    M Oddo
    Neurointensive Care Unit, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:916-20. 2009
    ..We examined the effects on brain tissue oxygen tension (PbtO(2)) of mannitol and hypertonic saline (HTS) in patients with severe traumatic brain injury (TBI) and refractory intracranial hypertension...
  57. ncbi Relationship between markers of lipid peroxidation, thiol oxidation and Glasgow coma scale scores of moderate head injury patients in the 7 day post-traumatic period
    Chandrika Nayak
    Department of Biochemistry, Melaka Manipal Medical College, International Centre for Health Sciences, Manipal 576104, Karnataka, India
    Neurol Res 30:461-4. 2008
    ..Thus, the current study analysed the post-traumatic changes in the erythrocyte markers of oxidative damage and the relationship between these parameters and Glasgow coma scale (GCS) scores of MHI patients during the 7 day study period.
  58. ncbi Using the abbreviated injury severity and Glasgow Coma Scale scores to predict 2-week mortality after traumatic brain injury
    Shelly D Timmons
    Department of Neurosurgery, Semmes Murphey Clinic and University of Tennessee Health Science Center, Memphis, Tennessee, USA
    J Trauma 71:1172-8. 2011
    ..We tested the use of a single hospital Glasgow Coma Scale (GCS) Score, GCS Motor Score, and the Head component of the Abbreviated Injury Scale (AIS) Score to predict ..
  59. ncbi Mortality prediction of head Abbreviated Injury Score and Glasgow Coma Scale: analysis of 7,764 head injuries
    Demetrios Demetriades
    Division of Trauma and SICU, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Am Coll Surg 199:216-22. 2004
    We assessed the prognostic value and limitations of Glasgow Coma Scale (GCS) and head Abbreviated Injury Score (AIS) and correlated head AIS with GCS.
  60. ncbi Successful use of the new high-dose mannitol treatment in patients with Glasgow Coma Scale scores of 3 and bilateral abnormal pupillary widening: a randomized trial
    Julio Cruz
    The Comprehensive International Center for Neuroemergencies and Federal University of São Paulo, SP, Brazil
    J Neurosurg 100:376-83. 2004
    ....
  61. ncbi Performance of the pediatric glasgow coma scale in children with blunt head trauma
    James F Holmes
    Department of Emergency Medicine, University of California, Davis, School of Medicine, Sacramento, CA, USA
    Acad Emerg Med 12:814-9. 2005
    To compare the accuracy of a pediatric Glasgow Coma Scale (GCS) score in preverbal children with blunt head trauma with the standard GCS score in older children.
  62. ncbi Predictive value of initial Glasgow coma scale score in pediatric trauma patients
    Mark X Cicero
    Department of Pediatrics, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT 06511, USA
    Pediatr Emerg Care 29:43-8. 2013
    The objective of this study was to determine the predictive value of the Glasgow coma scale (GCS) and the Glasgow motor component (GMC) for overall mortality, death on arrival, and major injury and the relationship between GCS and length ..
  63. ncbi Time-relative changes in the erythrocyte antioxidant enzyme activities and their relationship with Glasgow Coma Scale scores in severe head injury patients in the 21-day posttraumatic study period
    Chandrika D Nayak
    Department of Biochemistry, Melaka Manipal Medical College Manipal Campus, Manipal University, Manipal 576 104, India
    Indian J Med Sci 61:381-9. 2007
    ..Reactive oxygen species are indicated to play a prime role in the pathophysiology of brain damage following a severe head injury (SHI)...
  64. ncbi Decompressive hemicraniectomy in patients with supratentorial intracerebral hemorrhage
    Christian Fung
    Department of Neurosurgery, University Hospital Bern, 10 Freiburgstrasse, 3010 Bern, Switzerland
    Stroke 43:3207-11. 2012
    ..Its usefulness in intracerebral hemorrhage (ICH) is unclear. The aim of this study was to analyze feasibility and safety of DC without clot evacuation in ICH...
  65. ncbi Plasma d-dimer predicts poor outcome after acute intracerebral hemorrhage
    P Delgado
    Neurovascular Research Laboratory and the Stroke Unit, Departament de Medicina, Universitat Autonoma de Barcelona, Hospital General Vall d Hebron, Barcelona, Spain
    Neurology 67:94-8. 2006
    ..To investigate if systemic d-dimer activation occurs after acute intracerebral hemorrhage (ICH) and to study its influence on clinical outcome...
  66. ncbi D-dimer as a predictor of progressive hemorrhagic injury in patients with traumatic brain injury: analysis of 194 cases
    Heng Li Tian
    Department of Neurosurgery, Shanghai 6th People Hospital, Shanghai Jiaotong University, No 600, Yishan Road, Xuhui District, Shanghai, China 200233
    Neurosurg Rev 33:359-65; discussion 365-6. 2010
    ..850(P < 0.001). The level of plasma D-dimer after TBI can be a useful prognostic factor for PHI and should be considered in the clinical management of patients in combination with neuroimaging and other data...
  67. ncbi The Glasgow Coma Scale--a brief review. Past, present, future
    Georgios Matis
    Neurosurgery Department, Democritus University of Thrace, University General Hospital of Alexandroupolis, Greece
    Acta Neurol Belg 108:75-89. 2008
    The Glasgow Coma Scale (GCS) was introduced in 1974 aiming at standardizing assessment of level of consciousness in head injured patients...
  68. ncbi Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: an IMPACT analysis
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23219, USA
    J Neurotrauma 24:270-80. 2007
    We studied the prognostic strength of the individual components of the Glasgow Coma Scale (GCS) and pupil reactivity to Glasgow Outcome Score (GOS) at 6 months post-injury...
  69. ncbi Lipid emulsion improves Glasgow coma scale and decreases blood glucose level in the setting of acute non-local anesthetic drug poisoning--a randomized controlled trial
    F Taftachi
    Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Hazrat Rasoul Akram Hospital, Tehran, Iran
    Eur Rev Med Pharmacol Sci 16:38-42. 2012
    ..To date, no study has been performed to evaluate the antidotal effect of intravenous lipid emulsion on the poisoned patients' level of consciousness and routine metabolic profile tests in non-local anesthetic drug overdose...
  70. ncbi Posttraumatic cerebral infarction: incidence, outcome, and risk factors
    Isaac Tawil
    Division of Trauma Critical Care, Department of Surgery, University of New Mexico, Albuquerque, New Mexico, USA
    J Trauma 64:849-53. 2008
    ..We suspected that recent advances in imaging modalities and treatment might affect incidence and outcome. We sought to define the incidence and mortality impact of PTCI. We also identified risk factors associated with PTCI...
  71. ncbi Delayed diagnosis of thoracolumbar fractures in multiple-trauma patients
    S Anderson
    Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Acad Emerg Med 3:832-9. 1996
    ..To determine the frequency of delayed diagnosis of major thoracolumbar vertebral fractures (T-L Fxs) in ED multiple-trauma patients, and to determine the differences between cases of delayed and nondelayed diagnoses of T-L Fx...
  72. ncbi Early packed red blood cell transfusion and acute respiratory distress syndrome after trauma
    Onuma Chaiwat
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, Washington 98195 6540, USA
    Anesthesiology 110:351-60. 2009
    ..Transfusion of packed red blood cells (PRBCs) is a risk factor for acute respiratory distress syndrome (ARDS) in trauma patients. Yet, there is a paucity of information regarding the risk of ARDS with incremental PRBCs exposure...
  73. ncbi Glasgow Coma Scale on admission is correlated with postoperative Glasgow Outcome Scale in chronic subdural hematoma
    Abbass Amirjamshidi
    Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Neurosci 14:1240-1. 2007
    To evaluate the correlation between admission Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) in chronic subdural hematoma (CSDH).
  74. ncbi Severe traumatic brain injury in Switzerland - feasibility and first results of a cohort study
    Erik von Elm
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Swiss Med Wkly 138:327-34. 2008
    ..We aimed to study the incidence and outcome of severe traumatic brain injury (TBI) in Switzerland and to test the feasibility of a large cohort study with case identification in the first 24 hours and 6-month follow-up...
  75. ncbi Incidence of hospital-admitted severe traumatic brain injury and in-hospital fatality in Norway: a national cohort study
    N Andelic
    Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Ulleval, Oslo, Norway
    Neuroepidemiology 38:259-67. 2012
    ....
  76. ncbi Comparison of the Glasgow Coma Scale and the Reaction Level Scale for assessment of cerebral responsiveness in the critically ill
    Sten M Walther
    Department of Cardiothoracic Anaesthesia and Intensive Care, University Hospital, 58185, Linkoping, Sweden
    Intensive Care Med 29:933-8. 2003
    The Glasgow Coma Scale (GCS) is a well-known source of error in outcome prediction models. We compared assessment of cerebral responsiveness with the GCS and the Reaction Level Scale (RLS) in two otherwise similar outcome prediction models...
  77. ncbi The Glasgow Coma Scale and other neurological observations
    C Waterhouse
    Royal Hallamshire Hospital, Sheffield
    Nurs Stand 19:55-64; quiz 66-7. 2005
    The primary tool used by nurses to assess a patient's neurological status is the neurological observation chart incorporating the Glasgow Coma Scale. This article explains the correct use of the chart and how to interpret the findings.
  78. ncbi Diagnostic value of the Glasgow Coma Scale for traumatic brain injury in 18,002 patients with severe multiple injuries
    Stefan Grote
    Department of Trauma Surgery, Ludwig Maximilians University, Munich, Germany
    J Neurotrauma 28:527-34. 2011
    ..reasons for unconsciousness, traumatic brain injury (TBI) in these patients is frequently defined by the Glasgow Coma Scale (GCS). Nevertheless, the diagnostic value of GCS for severe TBI in the multiple-injured patient is unknown...
  79. ncbi The diagnostic accuracy of the Revised Westmead PTA Scale as an adjunct to the Glasgow Coma Scale in the early identification of cognitive impairment in patients with mild traumatic brain injury
    E A Shores
    Department of Psychology, Macquarie University, North Ryde, New South Wales 2109, Australia
    J Neurol Neurosurg Psychiatry 79:1100-6. 2008
    Assessment of patients with mild traumatic brain injury (mTBI) is predominantly done using the Glasgow Coma Scale (GCS)...
  80. ncbi Comparison of the Full Outline of UnResponsiveness and Glasgow Liege Scale/Glasgow Coma Scale in an intensive care unit population
    Marie Aurelie Bruno
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Sart Tilman B30, 4000 Liege, Belgium
    Neurocrit Care 15:447-53. 2011
    The Full Outline of UnResponsiveness (FOUR) has been proposed as an alternative for the Glasgow Coma Scale (GCS)/Glasgow Liège Scale (GLS) in the evaluation of consciousness in severely brain-damaged patients...
  81. ncbi Factors affecting mortality in patients with thorax trauma
    Sadiye Emircan
    Burhan Nalbantoğlu State Hospital, Lefkosa, TRNC
    Ulus Travma Acil Cerrahi Derg 17:329-33. 2011
    ..The purpose of this study was to define the epidemiologic properties and correlation of physiological and anatomical risk factors with the mortality rate among patients with thorax trauma and to ensure early prediction of severe trauma...
  82. ncbi Effectiveness and safety of noninvasive positive-pressure ventilation for severe hypercapnic encephalopathy due to acute exacerbation of chronic obstructive pulmonary disease: a prospective case-control study
    Guang Fa Zhu
    Department of Respiratory Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
    Chin Med J (Engl) 120:2204-9. 2007
    ....
  83. pmc Role of BiPAP applied through endotracheal tube in unconscious patients suffering from acute exacerbation of COPD: a pilot study
    Jagdish Rawat
    Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Jolly Grant, Dehradun, Uttarakhand, India
    Int J Chron Obstruct Pulmon Dis 7:321-5. 2012
    ..The main aim of this study was to evaluate the usefulness, safety and cost-effectiveness of bilevel positive airway pressure (BiPAP) applied via endotracheal tube in such patients...
  84. ncbi Serum neuron-specific enolase as a predictor of short-term outcome and its correlation with Glasgow Coma Scale in traumatic brain injury
    Aslan Guzel
    Department of Neurosurgery, Medical Faculty, Dicle University, Diyarbakir, Turkey
    Neurosurg Rev 31:439-44; discussion 444-5. 2008
    Elevated serum neuron-specific enolase levels are correlated with brain cell damage. Low scores according to Glasgow Coma Scale are also considered as serious poor prognostic factor...
  85. ncbi Agitation following traumatic brain injury: an Australian sample
    Melissa T Nott
    Faculty of Health Sciences, University of Sydney, NSW, Australia
    Brain Inj 20:1175-82. 2006
    ..The aims of this study were: (1) To examine the nature and incidence of agitation during TBI rehabilitation in an Australian sample; and (2) To explore the relationship between agitation and functional outcomes after TBI...
  86. ncbi Glasgow Coma Scale and hematoma volume as criteria for treatment of putaminal and thalamic intracerebral hemorrhage
    Der Yang Cho
    Department of Neurosurgery, Stroke Center, China Medical University Hospital, Taichung, Taiwan, Republic of China, 404
    Surg Neurol 70:628-33. 2008
    ..The decision to administer conservative or surgical treatment for putaminal and thalamic ICH is still a controversial issue. This study was undertaken to examine the decision-making criteria for these 2 treatments...
  87. ncbi Epidemiology, severity classification, and outcome of moderate and severe traumatic brain injury: a prospective multicenter study
    Teuntje M J C Andriessen
    Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Neurotrauma 28:2019-31. 2011
    ..Based on the emergency department Glasgow Coma Scale (GCS), 339 patients were classified as having severe and 129 as having moderate TBI...
  88. ncbi Management of severe head injury: institutional variations in care and effect on outcome
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, WA, USA
    Crit Care Med 30:1870-6. 2002
    ....
  89. ncbi The history of the Glasgow Coma Scale: implications for practice
    J Fischer
    Lehigh Valley Hospital, Allentown, Pennsylvania, USA
    Crit Care Nurs Q 23:52-8. 2001
    The Glasgow Coma Scale (GCS) has been the gold standard of neurologic assessment for trauma patients since its development by Jennett and Teasdale in the early 1970s. The GCS was found to be a simple tool to use...
  90. ncbi Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury
    Paul M Shore
    Department of Pediatrics, University of Texas Southwestern Medical Center, Division of Critical Care Services, Children s Medical Center of Dallas, 1935 Motor Street, Dallas, TX 73235, USA
    J Neurotrauma 24:75-86. 2007
    The Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) are widely used clinical scoring systems to measure the severity of neurologic injury after traumatic brain injury (TBI), but have recognized limitations in infants and small ..
  91. ncbi Prognostic influence and magnetic resonance imaging findings in paroxysmal sympathetic hyperactivity after severe traumatic brain injury
    Li Quan Lv
    Department of Neurosurgery, Shanghai Institute of Neurosurgery, Shanghai Changzheng Hospital, Shanghai, China
    J Neurotrauma 27:1945-50. 2010
    ..PSH occurred in 18.4% of patients, with a greater incidence among younger patients and those with lower Glasgow Coma Scale (GCS) scores...
  92. ncbi The prognostic value of the components of the Glasgow Coma Scale following acute stroke
    C J Weir
    Department of Medicine and Therapeutics, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    QJM 96:67-74. 2003
    The Glasgow Coma Scale (GCS) is widely used in assessing level of consciousness...
  93. ncbi The incidence of dysautonomia and its relationship with autonomic arousal following traumatic brain injury
    Ian J Baguley
    Brain Injury Rehabilitation Service, Westmead, NSW, Australia
    Brain Inj 21:1175-81. 2007
    ..To determine the incidence of autonomic arousal vs. Dysautonomia following traumatic brain injury (TBI) in an Intensive Care Unit (ICU) setting and to prospectively evaluate these groups against injury severity and outcome variables...
  94. ncbi Diffusion-weighted MR imaging in closed head injury: high correlation with initial glasgow coma scale score and score on modified Rankin scale at discharge
    Pamela W Schaefer
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Gray B285, Boston, MA 02114, USA
    Radiology 233:58-66. 2004
    To determine whether diffusion-weighted magnetic resonance (MR) imaging findings and conventional MR imaging findings correlate with initial Glasgow Coma Scale score and score on modified Rankin scale at discharge.
  95. ncbi Physician knowledge of the Glasgow Coma Scale
    Ronald G Riechers
    Department of Neurology, Walter Reed Army Medical Center, Washington, D C 20307, USA
    J Neurotrauma 22:1327-34. 2005
    Appropriate triage is critical to optimizing outcome from battle related injuries. The Glasgow Coma Scale (GCS) is the primary means by which combat casualties, who have suffered head injury, are triaged...
  96. pmc Comparison of APACHE II, MEES and Glasgow Coma Scale in patients with nontraumatic coma for prediction of mortality. Acute Physiology and Chronic Health Evaluation. Mainz Emergency Evaluation System
    S Grmec
    Emergency Medical Service, Maribor Teaching Hospital, Ljubljanska, Slovakia
    Crit Care 5:19-23. 2001
    ..The purpose of the present study was to assess the value of the various scoring systems in predicting outcome in nontraumatic coma patients and to evaluate the importance of mental status measurement in relation to outcome...
  97. ncbi A multiple imputation model for imputing missing physiologic data in the national trauma data bank
    Lynne Moore
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    J Am Coll Surg 209:572-9. 2009
    ..Multiple imputation (MI) has been proposed to simulate missing Glasgow Coma Scale (GCS) scores, respiratory rate (RR), and systolic blood pressure (SBP)...
  98. pmc Knowledge of Glasgow coma scale by air-rescue physicians
    Catherine Heim
    Department of Anesthesiology, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Scand J Trauma Resusc Emerg Med 17:39. 2009
    To assess the theoretical and practical knowledge of the Glasgow Coma Scale (GCS) by trained Air-rescue physicians in Switzerland.
  99. ncbi The relation between Glasgow Coma Scale score and later cerebral atrophy in paediatric traumatic brain injury
    Alokananda Ghosh
    E B Singleton Department of Diagnostic Imaging, Texas Children s Hospital, Houston, TX, USA
    Brain Inj 23:228-33. 2009
    To examine initial Glasgow Coma Scale (GCS) score and its relationship with later cerebral atrophy in children with traumatic brain injury (TBI) using Quantitative Magnetic Resonance Imaging (QMRI) at 4 months post-injury...
  100. doi Validation of a prognostic subarachnoid hemorrhage grading scale derived directly from the Glasgow Coma Scale
    Annemarie W van Heuven
    Stroke 39:1347-8. 2008
    A new Glasgow Coma Scale-based scale has been developed to predict patient outcome in subarachnoid hemorrhage by calculating cut-off points by which 2 consecutive categories corresponded to a statistically significant different outcome...
  101. ncbi A review of the predictive ability of Glasgow Coma Scale scores in head-injured patients
    Molly McNett
    Kent State University, Kent, OH, USA
    J Neurosci Nurs 39:68-75. 2007
    ..The Glasgow Coma Scale (GCS) score is one variable that was extensively studied for its ability to predict outcome in TBI patients...

Research Grants64

  1. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2004
    ..Patients with moderate or severe head injury (post-resuscitation Glasgow Coma Scale 3-12 or having an early craniotomy) are randomized to receive moderate doses of magnesium sulfate or placebo...
  2. Are Volume Standards Accurate Measures of Quality?
    Laurent Glance; Fiscal Year: 2005
    ..abstract_text> ..
  3. Prospective Memory in Normal and Head-Injured Children
    Stephen McCauley; Fiscal Year: 2005
    ..The fourth aim is to determine which cortical structures (specifically prefrontal cortex) are involved in PM functioning through the use of fMRI. ..
  4. Effectiveness of ICP Monitoring in Pediatric Traumatic Brain Injury
    TELLEN BENNETT; Fiscal Year: 2013
    ..The available evidence to support acute interventions in children with severe TBI (Glasgow Coma Scale d 8) is limited...
  5. Macrostructural and Microstructural Imaging Biomarkers of Traumatic Brain Injury
    Pratik Mukherjee; Fiscal Year: 2012
    ..outcomes at one year after injury, after controlling for clinical measures of injury severity including Glasgow Coma Scale, duration of unconsciousness, and duration of post-traumatic amnesia...
  6. Biochemical Markers of Traumatic Brain Injury
    STEVEN ANDREW ROBICSEK; Fiscal Year: 2010
    ..g. Glasgow Coma Scale-GCS), injury type (e.g. diffuse injury vs. mass lesion), occurrence of secondary insults (e.g...
  7. Biomarkers of Injury and Outcome in Pro-TECT III (BIO-ProTECT)
    MICHAEL ROSS FRANKEL; Fiscal Year: 2013
    ..levels of S100B, GFAP, UCH-L1 and SBDP150 are more accurate predictors of the extent of injury than the Glasgow Coma Scale and computed tomography...
  8. EARLY HEMICRANIECTOMY TO MANAGE TRAUMATIC BRAIN INJURY
    William Coplin; Fiscal Year: 1999
    ..The study will randomly assign, within 24 hours of ictus, 92 TBI patients, Glasgow Coma Scale score less than or equal to 9, with midline shift greater than the size of a surgically removable hematoma...
  9. Pediatric Mild Head Injury: Definition and Consequences
    Ronald Maio; Fiscal Year: 2004
    ..b>Glasgow Coma Scale scores will be 13-15 with no intracranial pathology on any neuroimaging studies...
  10. Antihypertensive Treatment in Acute Cerebral Hemorrhage
    Adnan Qureshi; Fiscal Year: 2006
    ..The primary safety outcome will be neurological deterioration defined by a decline in Glasgow Coma Scale by 2 points or greater or increase in National Institute of Health Stroke Scale score by 4 points or greater...
  11. Proton Magnetic Resonance Spectroscopy of Acute TBI
    John DeLuca; Fiscal Year: 2003
    ..Acute rating scales such as the Glasgow Coma Scale (GCS) have shown limited predictive validity regarding patient outcome and traditional neuroimaging ..
  12. CSF MAP-2 IN TRAUMATIC BRAIN INJURY
    Frank Zemlan; Fiscal Year: 1999
    ..patient clinical improvement and CSF MAP-2 levels will be determined by comparing CSF MAP-2 levels with the Glasgow Coma Scale scores of TBI patients during hospitalization...
  13. Brain Trauma Assessment System
    John Sewell; Fiscal Year: 2005
    ..Phase I demonstrated that, unlike the current Glasgow Coma Scale, a PDA-hosted, non-invasive, passive acoustic monitoring system can accurately distinguish early-stage TBI ..
  14. POLYGRAPHIC PATTERNS IN NEUROL
    EVELYN ELWELL; Fiscal Year: 1980
    ..Coma Scales, Polysomnographic states, and serial electroencephalograms of comatose patients whose initial Glasgow Coma Scale Scores range from 3 to 10...
  15. MEDIC ONE STROKE SCALE
    David Tirschwell; Fiscal Year: 2003
    ..reliability and predictive value of the MOSS will be validated in the second cohort and compared with the Glasgow Coma Scale and medical record abstracted NIHSS...
  16. Clinical Decision Rule to Identify Children with Intra-Abdominal Injuries
    James Holmes; Fiscal Year: 2008
    ..unreadable]..
  17. Hemodynamics and Outcome in Pediatric Brain Injury
    MONICA VAVILALA; Fiscal Year: 2007
    ..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
  18. Cerebral Edema in Pediatric Diabetic Ketoacidosis
    MONICA VAVILALA; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  19. SELF-MANAGEMENT OF SICKLE CELL DISEASE
    Stephen McCauley; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  20. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  21. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  22. Cognitive Recovery after Traumatic Brain Injury
    Maureen Schmitter Edgecombe; Fiscal Year: 2007
    ....
  23. Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBI
    Amy Wagner; Fiscal Year: 2008
    ..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
  24. CPP Management Information Feedback and Nursing
    Catherine Kirkness; Fiscal Year: 2007
    ..abstract_text> ..
  25. Dopamine Genetic Variants Modulating Recovery After TBI
    Amy Wagner; Fiscal Year: 2008
    ..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. [unreadable] [unreadable] [unreadable]..
  26. PHARMACOLOGIC REHABILITATION OF ATTENTION DEFICITS
    John Whyte; Fiscal Year: 2003
    ..The factor structure will also be compared to that obtained from a control sample. ..
  27. Detecting Axonal Damage After Mild Traumatic Brain Injury
    Jeffrey Bazarian; Fiscal Year: 2009
    ....
  28. Epidemiology of Traumatic Brain Injury
    Jeffrey Bazarian; Fiscal Year: 2005
    ....
  29. STUDY OF FUNCTIONAL OUTCOME AFTER TRAUMA IN ADOLESCENTS
    Troy Holbrook; Fiscal Year: 2002
    ..The true efficacy of trauma care systems in this country can only be demonstrated by addressing whether these systems return trauma victims to active functional roles in society. ..
  30. Gender Differences in Dopamine Function after TBI
    Amy Wagner; Fiscal Year: 2003
    ....
  31. ACCIDENTAL AND NONACCIDENTAL PEDIATRIC BRAIN INJURY
    Linda Ewing Cobbs; Fiscal Year: 2004
    ..abstract_text> ..
  32. Dopamine Function in TBI--Therapeutic Intervention
    Amy Wagner; Fiscal Year: 2005
    ..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
  33. Deficit of Awareness in Traumatic Brain Injury
    KATHLEEN PAGULAYAN; Fiscal Year: 2005
    ....
  34. Trauma Center Brief Alcohol Treatments and Cost Effectivenes
    Thomas J Esposito; Fiscal Year: 2010
    ..New knowledge of the effectiveness, benefits and costs of these two Bl approaches would allow surgeons and trauma centers to make informed choices about alcohol interventions in trauma settings. ..
  35. Neurorehabilitation with Progesterone & Pregnenolone
    David Wright; Fiscal Year: 2005
    ..Therefore, we will examine two delayed treatment paradigms (7 days & 28 days post injury) on the recovery process at the behavioral and morphological levels of analysis. ..
  36. ProTECT II: Progesterone for TBI, MCCT Planning Grant
    David Wright; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. POST CONCUSSIVE SYMPTOMS: CHILDREN WITH MILD HEAD INJURY
    Keith Yeates; Fiscal Year: 2005
    ..The findings will help resolve the scientific controversy regarding the outcomes associated with mild CHI, and will assist physicians and other health care providers in identifying the sequelae of mild CHI and managing them effectively. ..
  38. Outcomes of Traumatic Brain Injury
    Heather Keenan; Fiscal Year: 2007
    ..In addition to publications, data from this mentored research will be used to develop additional, independent research awards. ..
  39. BRAIN INJURY, AGING AND NEURODEGENERATION IN THE RAT
    Douglas Smith; Fiscal Year: 2004
    ..Success of these studies may reveal mechanistic links between brain trauma, age and neurodegenerative processes and provide a basis for the development of new therapeutic strategies. ..
  40. Memory and attention in people who experienced a single life-threatening event
    Brian Levine; Fiscal Year: 2009
    ....
  41. TRAUMA-RELATED ERYTHROPOIETIC SUPPRESSION
    David Livingston; Fiscal Year: 2003
    ..Understanding the mechanisms behind post-trauma anemia will allow therapeutic interventions improving endogenous erythropoiesis to be targeted. ..
  42. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2010
    ..Documenting definitive evidence of the tuned-dynamic absorber model could have fundamental implications to all ICP disorders. ..
  43. Computer Adaptive Testing of Pediatric Self-care and Social Function
    Stephen Haley; Fiscal Year: 2006
    ..Many rehabilitation settings may also find this measure helpful in meeting accreditation and institutional requirements for standardizing outcome monitoring in groups of children. [unreadable] [unreadable] [unreadable]..
  44. Early School Progress in <1000g Birthweight Children
    H Gerry Taylor; Fiscal Year: 2010
    ..The findings will inform efforts to identify and treat learning disorders in high-risk children at school entry. ..
  45. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
    ..Based on results from initial analyses and developing collaborations with other research groups future research projects, such as a genome-wide screen of OCD, are considered. ..
  46. Social Outcomes in Pediatric Traumatic Brain Injury
    Keith O Yeates; Fiscal Year: 2010
    ..By helping to better understand social outcomes after childhood TBI, the study's findings may suggest ways to promote children's behavioral adaptation to the functional losses and disabilities that frequently occur after TBI. ..
  47. ALCOHOL ABUSE AND DEPENDENCE IN TRAUMA PATIENTS
    Patricia Dischinger; Fiscal Year: 2002
    ..The validity of self reports will be assessed by interviewing collaterals from 100 randomly selected patients in each of the intervention and control groups at 6 and 12 months. ..
  48. Phone Cognitive Behavioral Therapy for Depression after Traumatic Brain Injury
    JESSE FANN; Fiscal Year: 2008
    ..This project will culminate in the design of a trial of CBT-TBI in a large, representative sample of people with TBI and depression. [unreadable] [unreadable] [unreadable]..
  49. OPTIMAL PREHOSPITAL CARE OF CHILDHOOD CARDIAC ARREST
    Ian Stiell; Fiscal Year: 2004
    ..The PIs propose to conduct a large feasibility review in five urban areas and to conduct four study planning workshops. ..
  50. MECHANISMS OF SECONDARY INJURY IN CEREBRAL HEMORRHAGE
    ALLYSON ZAZULIA; Fiscal Year: 2007
    ..These hypotheses will be tested using sequential PET or MRI studies in 60 patients with acute ICH. ..
  51. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2007
    ..Elucidation of macrophage and T-cell cytokine responses to infection in G6PD deficiency may also be important in providing a mechanism of malaria protection alternative to currently accepted notions. [unreadable] [unreadable]..
  52. In Vivo Imaging of Post-Traumatic Cerebral Amyloid Deposition
    Marvin Bergsneider; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. PS06-003, Opt-out HIV Testing in Emergency Dept settings
    Jason Haukoos; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Vascular Comorbidities and DTI Measured White Matter Damage in AD
    Felicia Goldstein; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. 26th Princeton Conference on Cerebrovascular Disease
    James Grotta; Fiscal Year: 2008
    ..All presentations and discussion will be recorded and published. [unreadable] [unreadable] [unreadable]..
  56. SEVERE MALARIA IN AFRICAN CHILDREN: A CLINICAL NETWORK
    Terrie Taylor; Fiscal Year: 2004
    ..Given the enormous toll of malaria, this could re resent a significant decline in the death rate across sub-Saharan Africa. ..
  57. New Frontiers in Pediatric Traumatic Brain Injury
    Keith Yeates; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. Post Traumatic Brain Injury (TBI) Depression
    Vani Rao; Fiscal Year: 2008
    ..All three hypotheses will hold true at each time point, even when gender, personal past psychiatric history, family history, and alcohol/substance abuse/depedence are adjusted for in the analysis. [unreadable] [unreadable]..
  59. Role of Candidate Alleles in Cognitive Outcome After TBI
    Thomas McAllister; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Computer Adaptive Testing of Functional Status
    Stephen Haley; Fiscal Year: 2008
    ..abstract_text> ..
  61. A Comprehensive Surveillance of Occ Injury in Maryland
    Patricia Dischinger; Fiscal Year: 2005
    ..6) To identify priority areas for injury prevention within the state of Maryland, based on groups of workers at high risk of injury. ..
  62. SCHOOL AGE CONSEQUENCES OF <750 GRAM BIRTHWEIGHT
    H Taylor; Fiscal Year: 2002
    ..Results will clarify the long-term sequelae of less than 750 g birth weight and shed light on the bases of both adverse consequences and developmental sparing. ..